What is the best way to travel from Louisville, KY to Chicago?
Looking for a trip? Compare all the available Buses and Flights for the journey to Chicago from Louisville, KY. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
What is the cheapest way to reach Chicago from Louisville, KY?
You can get to Chicago with just $44 by taking a Bus from Greyhound US, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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FlixBus5h 20m07:30 PMLouisville, KYGreyhound Bus Station11:50 PMChicago95th Red Line Station0EconomyA Bus from FlixBus goes from Greyhound Bus Station, Louisville, KY (USA) at 12/5/2025 7:30:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/5/2025 11:50:00 PM. 50 Economy ticket for $45 per person are available. Travel duration is 5h 20m
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Greyhound US6h 40m08:00 AMLouisville, KYGreyhound Bus Station1:40 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 12/5/2025 8:00:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/5/2025 1:40:00 PM. 50 Economy ticket for $47 per person are available. Travel duration is 6h 40m
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Greyhound US7h 55m010:10 AMLouisville, KYGreyhound Bus Station5:05 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 12/5/2025 10:10:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/5/2025 5:05:00 PM. 50 Economy ticket for $47 per person are available. Travel duration is 7h 55m
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FlixBus7h 15m04:50 AMLouisville, KYGreyhound Bus Station11:05 AMChicago95th Red Line Station0EconomyA Bus from FlixBus goes from Greyhound Bus Station, Louisville, KY (USA) at 12/5/2025 4:50:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/5/2025 11:05:00 AM. 50 Economy ticket for $53 per person are available. Travel duration is 7h 15m
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Greyhound US8h 0m02:50 AMLouisville, KYGreyhound Bus Station9:50 AMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 12/5/2025 2:50:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/5/2025 9:50:00 AM. 50 Economy ticket for $60 per person are available. Travel duration is 8h 0m
Cheapest Buses Friday
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Greyhound US7h 10m08:00 AMLouisville, KYGreyhound Bus Station2:10 PMChicagoUnion Station0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 12/6/2025 8:00:00 AM to Union Station, Chicago (USA) arriving at 12/6/2025 2:10:00 PM. 50 Economy ticket for $47 per person are available. Travel duration is 7h 10m
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Greyhound US7h 35m08:00 AMLouisville, KYGreyhound Bus Station2:35 PMChicagoDowntown Bus Station0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 12/6/2025 8:00:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/6/2025 2:35:00 PM. 50 Economy ticket for $47 per person are available. Travel duration is 7h 35m
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Greyhound US6h 5m010:10 AMLouisville, KYGreyhound Bus Station3:15 PMChicagoDowntown Bus Station0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 12/6/2025 10:10:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/6/2025 3:15:00 PM. 50 Economy ticket for $47 per person are available. Travel duration is 6h 5m
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FlixBus5h 40m07:30 PMLouisville, KYGreyhound Bus Station12:10 AMChicagoDowntown Bus Station0EconomyA Bus from FlixBus goes from Greyhound Bus Station, Louisville, KY (USA) at 12/6/2025 7:30:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/7/2025 12:10:00 AM. 50 Economy ticket for $49 per person are available. Travel duration is 5h 40m
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FlixBus7h 40m04:50 AMLouisville, KYGreyhound Bus Station11:30 AMChicagoDowntown Bus Station0EconomyA Bus from FlixBus goes from Greyhound Bus Station, Louisville, KY (USA) at 12/6/2025 4:50:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/6/2025 11:30:00 AM. 50 Economy ticket for $54 per person are available. Travel duration is 7h 40m
Cheapest Buses Saturday
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Greyhound US6h 35m02:35 PMLouisville, KYGreyhound Bus Station8:10 PMChicagoDowntown Bus Station0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 12/8/2025 2:35:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/8/2025 8:10:00 PM. 50 Economy ticket for $45 per person are available. Travel duration is 6h 35m
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FlixBus5h 20m07:30 PMLouisville, KYGreyhound Bus Station11:50 PMChicago95th Red Line Station0EconomyA Bus from FlixBus goes from Greyhound Bus Station, Louisville, KY (USA) at 12/8/2025 7:30:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/8/2025 11:50:00 PM. 50 Economy ticket for $45 per person are available. Travel duration is 5h 20m
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Greyhound US8h 0m02:50 AMLouisville, KYGreyhound Bus Station9:50 AMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 12/8/2025 2:50:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/8/2025 9:50:00 AM. 50 Economy ticket for $47 per person are available. Travel duration is 8h 0m
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Greyhound US7h 55m010:10 AMLouisville, KYGreyhound Bus Station5:05 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 12/8/2025 10:10:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/8/2025 5:05:00 PM. 50 Economy ticket for $47 per person are available. Travel duration is 7h 55m
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FlixBus5h 40m07:30 PMLouisville, KYGreyhound Bus Station12:10 AMChicagoDowntown Bus Station0EconomyA Bus from FlixBus goes from Greyhound Bus Station, Louisville, KY (USA) at 12/8/2025 7:30:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/9/2025 12:10:00 AM. 50 Economy ticket for $47 per person are available. Travel duration is 5h 40m
Cheapest Buses Monday
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Greyhound US9h 25m02:35 PMLouisville, KYGreyhound Bus Station11:00 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 12/11/2025 2:35:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/11/2025 11:00:00 PM. 50 Economy ticket for $44 per person are available. Travel duration is 9h 25m
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Greyhound US8h 0m02:50 AMLouisville, KYGreyhound Bus Station9:50 AMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 12/11/2025 2:50:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/11/2025 9:50:00 AM. 50 Economy ticket for $46 per person are available. Travel duration is 8h 0m
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Greyhound US7h 55m010:10 AMLouisville, KYGreyhound Bus Station5:05 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 12/11/2025 10:10:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/11/2025 5:05:00 PM. 50 Economy ticket for $46 per person are available. Travel duration is 7h 55m
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FlixBus5h 20m07:30 PMLouisville, KYGreyhound Bus Station11:50 PMChicago95th Red Line Station0EconomyA Bus from FlixBus goes from Greyhound Bus Station, Louisville, KY (USA) at 12/11/2025 7:30:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/11/2025 11:50:00 PM. 50 Economy ticket for $51 per person are available. Travel duration is 5h 20m
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FlixBus7h 15m04:50 AMLouisville, KYGreyhound Bus Station11:05 AMChicago95th Red Line Station0EconomyA Bus from FlixBus goes from Greyhound Bus Station, Louisville, KY (USA) at 12/11/2025 4:50:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/11/2025 11:05:00 AM. 50 Economy ticket for $56 per person are available. Travel duration is 7h 15m
Cheapest Buses Thursday
What are the fastest trips from Louisville, KY to Chicago?
You can get to Chicago from Louisville, KY in just 5h 20m with a Bus from FlixBus. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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FlixBus5h 20m07:30 PMLouisville, KYGreyhound Bus Station11:50 PMChicago95th Red Line Station0EconomyA Bus from FlixBus goes from Greyhound Bus Station, Louisville, KY (USA) at 12/5/2025 7:30:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/5/2025 11:50:00 PM. 50 Economy ticket for $45 per person are available. Travel duration is 5h 20m
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Greyhound US6h 40m08:00 AMLouisville, KYGreyhound Bus Station1:40 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 12/5/2025 8:00:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/5/2025 1:40:00 PM. 50 Economy ticket for $47 per person are available. Travel duration is 6h 40m
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FlixBus7h 15m04:50 AMLouisville, KYGreyhound Bus Station11:05 AMChicago95th Red Line Station0EconomyA Bus from FlixBus goes from Greyhound Bus Station, Louisville, KY (USA) at 12/5/2025 4:50:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/5/2025 11:05:00 AM. 50 Economy ticket for $53 per person are available. Travel duration is 7h 15m
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Greyhound US7h 55m010:10 AMLouisville, KYGreyhound Bus Station5:05 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 12/5/2025 10:10:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/5/2025 5:05:00 PM. 50 Economy ticket for $47 per person are available. Travel duration is 7h 55m
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Greyhound US8h 0m02:50 AMLouisville, KYGreyhound Bus Station9:50 AMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 12/5/2025 2:50:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/5/2025 9:50:00 AM. 50 Economy ticket for $60 per person are available. Travel duration is 8h 0m
Fastest Buses Friday
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FlixBus5h 40m07:30 PMLouisville, KYGreyhound Bus Station12:10 AMChicagoDowntown Bus Station0EconomyA Bus from FlixBus goes from Greyhound Bus Station, Louisville, KY (USA) at 12/6/2025 7:30:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/7/2025 12:10:00 AM. 50 Economy ticket for $49 per person are available. Travel duration is 5h 40m
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Greyhound US6h 5m010:10 AMLouisville, KYGreyhound Bus Station3:15 PMChicagoDowntown Bus Station0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 12/6/2025 10:10:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/6/2025 3:15:00 PM. 50 Economy ticket for $47 per person are available. Travel duration is 6h 5m
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Greyhound US7h 10m08:00 AMLouisville, KYGreyhound Bus Station2:10 PMChicagoUnion Station0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 12/6/2025 8:00:00 AM to Union Station, Chicago (USA) arriving at 12/6/2025 2:10:00 PM. 50 Economy ticket for $47 per person are available. Travel duration is 7h 10m
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Greyhound US7h 35m08:00 AMLouisville, KYGreyhound Bus Station2:35 PMChicagoDowntown Bus Station0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 12/6/2025 8:00:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/6/2025 2:35:00 PM. 50 Economy ticket for $47 per person are available. Travel duration is 7h 35m
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FlixBus7h 40m04:50 AMLouisville, KYGreyhound Bus Station11:30 AMChicagoDowntown Bus Station0EconomyA Bus from FlixBus goes from Greyhound Bus Station, Louisville, KY (USA) at 12/6/2025 4:50:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/6/2025 11:30:00 AM. 50 Economy ticket for $54 per person are available. Travel duration is 7h 40m
Fastest Buses Saturday
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FlixBus5h 20m07:30 PMLouisville, KYGreyhound Bus Station11:50 PMChicago95th Red Line Station0EconomyA Bus from FlixBus goes from Greyhound Bus Station, Louisville, KY (USA) at 12/8/2025 7:30:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/8/2025 11:50:00 PM. 50 Economy ticket for $45 per person are available. Travel duration is 5h 20m
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FlixBus5h 40m07:30 PMLouisville, KYGreyhound Bus Station12:10 AMChicagoDowntown Bus Station0EconomyA Bus from FlixBus goes from Greyhound Bus Station, Louisville, KY (USA) at 12/8/2025 7:30:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/9/2025 12:10:00 AM. 50 Economy ticket for $47 per person are available. Travel duration is 5h 40m
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Greyhound US6h 35m02:35 PMLouisville, KYGreyhound Bus Station8:10 PMChicagoDowntown Bus Station0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 12/8/2025 2:35:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/8/2025 8:10:00 PM. 50 Economy ticket for $45 per person are available. Travel duration is 6h 35m
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Greyhound US7h 55m010:10 AMLouisville, KYGreyhound Bus Station5:05 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 12/8/2025 10:10:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/8/2025 5:05:00 PM. 50 Economy ticket for $47 per person are available. Travel duration is 7h 55m
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Greyhound US8h 0m02:50 AMLouisville, KYGreyhound Bus Station9:50 AMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 12/8/2025 2:50:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/8/2025 9:50:00 AM. 50 Economy ticket for $47 per person are available. Travel duration is 8h 0m
Fastest Buses Monday
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FlixBus5h 20m07:30 PMLouisville, KYGreyhound Bus Station11:50 PMChicago95th Red Line Station0EconomyA Bus from FlixBus goes from Greyhound Bus Station, Louisville, KY (USA) at 12/11/2025 7:30:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/11/2025 11:50:00 PM. 50 Economy ticket for $51 per person are available. Travel duration is 5h 20m
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FlixBus7h 15m04:50 AMLouisville, KYGreyhound Bus Station11:05 AMChicago95th Red Line Station0EconomyA Bus from FlixBus goes from Greyhound Bus Station, Louisville, KY (USA) at 12/11/2025 4:50:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/11/2025 11:05:00 AM. 50 Economy ticket for $56 per person are available. Travel duration is 7h 15m
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Greyhound US7h 55m010:10 AMLouisville, KYGreyhound Bus Station5:05 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 12/11/2025 10:10:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/11/2025 5:05:00 PM. 50 Economy ticket for $46 per person are available. Travel duration is 7h 55m
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Greyhound US8h 0m02:50 AMLouisville, KYGreyhound Bus Station9:50 AMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 12/11/2025 2:50:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/11/2025 9:50:00 AM. 50 Economy ticket for $46 per person are available. Travel duration is 8h 0m
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Greyhound US9h 25m02:35 PMLouisville, KYGreyhound Bus Station11:00 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 12/11/2025 2:35:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/11/2025 11:00:00 PM. 50 Economy ticket for $44 per person are available. Travel duration is 9h 25m
Fastest Buses Thursday
Here you will find all operators and timetables for a
Bus from Louisville, KY to Chicago
What are the most popular stations in Louisville, KY and Chicago?
In Louisville, KY, you will usually depart from Greyhound Bus Station, International Airport or Convention Center, while in Chicago you will be arriving at California & 35th Street Bus Stop, Downtown Bus Station or 95th Red Line Station, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Chicago from Louisville, KY? With 5 connections between 2 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Louisville, KY and Chicago, you can pay as low as $44 with a Bus from Greyhound US.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Bus from FlixBus: you will get to Chicago in just 5h 20m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Louisville, KY and Chicago are Greyhound US and FlixBus, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Louisville, KY and Chicago is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from New Albany, IN or to Cicero, IL, and look at flights from , and landing at Chicago Midway Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Louisville, KY to Chicago?
The most popular companies between Louisville, KY and Chicago, are Greyhound US and FlixBus. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Greyhound US and FlixBus
All you need to know when you travel from Louisville, KY to Chicago
Check all information on comfort and services on all modes of transports from Louisville, KY to Chicago. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Louisville, KY to Chicago
How can I reach Chicago from Louisville, KY?
Every day, there are on average 5 connections between Bus and Flight, with which you can get to Chicago from Louisville, KY.
How far is Chicago from Louisville, KY?
The distance between Louisville, KY and Chicago is 269.3 miles.
What is the most ecofriendly mode of transport between Louisville, KY and Chicago?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 12 kgs of CO2, a train 15 kgs, a car 74 kgs, and a flight 107 kgs.
What is the cheapest mode of transport from Louisville, KY to Chicago?
You can get to Chicago with just $44 by taking a Bus from Greyhound US.
What is the fastest way to get from Louisville, KY to Chicago?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Chicago in just 5h 20m with a Bus from FlixBus.
More routes to Louisville, KY and to Chicago
Looking for more options? Here you can see the most popular routes to Louisville, KY and to Chicago. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Louisville, KY
- Chicago to Louisville, KY
- Dallas to Louisville, KY
- Houston to Louisville, KY
- New York to Louisville, KY
- Orlando, FL to Louisville, KY
- Phoenix, AZ to Louisville, KY
- Trips to Chicago
- Aguascalientes to Chicago
- Atlanta, GA to Chicago
- Bloomington, IN to Chicago
- Buffalo, NY to Chicago
- Ciudad Juárez to Chicago
- Dallas to Chicago
- El Paso, TX to Chicago
- Guadalajara, JC to Chicago
- Houston to Chicago
- London, ON to Chicago
- Memphis to Chicago
- Mexico City to Chicago
- Monterrey, NL to Chicago
- New York to Chicago
- Niagara Falls, ON to Chicago
- Nuevo Laredo to Chicago
- Pearson Toronto Airport to Chicago
- San Antonio, TX to Chicago
- San Diego to Chicago
- San Luis Potosí to Chicago
- St. Louis, MO to Chicago
- Toronto, ON to Chicago
- Tulsa to Chicago

