Bus Louisville, KY to Chicago: Compare prices and save money

Compare all timetables for the bus from Louisville, KY to Chicago

Here is a selection of the cheapest bus trips from the schedule from Louisville, KY to Chicago from various bus operators like Greyhound US or FlixBus for the next days.

today

$55

tomorrow

$31

Thursday

Friday

$57

Saturday

$39

Sunday

$40

Monday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	5h 20m	7:30 PM	Louisville, KY	Greyhound Bus Station	11:50 PM	Chicago	95th Red Line Station	Economy	$55	A Bus from FlixBus goes from Greyhound Bus Station, Louisville, KY (USA) at 3/24/2026 7:30:00 PM to 95th Red Line Station, Chicago (USA) arriving at 3/24/2026 11:50:00 PM. 50 Economy ticket for $55 per person are available. Travel duration is 5h 20m
FlixBus	5h 40m	7:30 PM	Louisville, KY	Greyhound Bus Station	12:10 AM	Chicago	Downtown Bus Station	Economy	$55	A Bus from FlixBus goes from Greyhound Bus Station, Louisville, KY (USA) at 3/24/2026 7:30:00 PM to Downtown Bus Station, Chicago (USA) arriving at 3/25/2026 12:10:00 AM. 50 Economy ticket for $55 per person are available. Travel duration is 5h 40m
Greyhound US	7h 10m	8:00 AM	Louisville, KY	Greyhound Bus Station	2:10 PM	Chicago	Canal & Van Buren	Economy	$64	A Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 3/24/2026 8:00:00 AM to Canal & Van Buren, Chicago (USA) arriving at 3/24/2026 2:10:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 7h 10m
Greyhound US	6h 40m	8:00 AM	Louisville, KY	Greyhound Bus Station	1:40 PM	Chicago	95th Red Line Station	Economy	$64	A Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 3/24/2026 8:00:00 AM to 95th Red Line Station, Chicago (USA) arriving at 3/24/2026 1:40:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 6h 40m
Greyhound US	7h 35m	8:00 AM	Louisville, KY	Greyhound Bus Station	2:35 PM	Chicago	Downtown Bus Station	Economy	$64	A Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 3/24/2026 8:00:00 AM to Downtown Bus Station, Chicago (USA) arriving at 3/24/2026 2:35:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 7h 35m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	7h 35m	8:00 AM	Louisville, KY	Greyhound Bus Station	2:35 PM	Chicago	Downtown Bus Station	Economy	$31	A Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 3/25/2026 8:00:00 AM to Downtown Bus Station, Chicago (USA) arriving at 3/25/2026 2:35:00 PM. 50 Economy ticket for $31 per person are available. Travel duration is 7h 35m
Greyhound US	6h 35m	2:35 PM	Louisville, KY	Greyhound Bus Station	8:10 PM	Chicago	Downtown Bus Station	Economy	$31	A Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 3/25/2026 2:35:00 PM to Downtown Bus Station, Chicago (USA) arriving at 3/25/2026 8:10:00 PM. 50 Economy ticket for $31 per person are available. Travel duration is 6h 35m
Greyhound US	7h 10m	8:00 AM	Louisville, KY	Greyhound Bus Station	2:10 PM	Chicago	Union Station	Economy	$31	A Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 3/25/2026 8:00:00 AM to Union Station, Chicago (USA) arriving at 3/25/2026 2:10:00 PM. 50 Economy ticket for $31 per person are available. Travel duration is 7h 10m
FlixBus	5h 40m	7:30 PM	Louisville, KY	Greyhound Bus Station	12:10 AM	Chicago	Downtown Bus Station	Economy	$35	A Bus from FlixBus goes from Greyhound Bus Station, Louisville, KY (USA) at 3/25/2026 7:30:00 PM to Downtown Bus Station, Chicago (USA) arriving at 3/26/2026 12:10:00 AM. 50 Economy ticket for $35 per person are available. Travel duration is 5h 40m
FlixBus	5h 20m	7:30 PM	Louisville, KY	Greyhound Bus Station	11:50 PM	Chicago	95th Red Line Station	Economy	$35	A Bus from FlixBus goes from Greyhound Bus Station, Louisville, KY (USA) at 3/25/2026 7:30:00 PM to 95th Red Line Station, Chicago (USA) arriving at 3/25/2026 11:50:00 PM. 50 Economy ticket for $35 per person are available. Travel duration is 5h 20m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	6h 5m	10:10 AM	Louisville, KY	Greyhound Bus Station	3:15 PM	Chicago	Downtown Bus Station	Economy	$57	A Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 3/27/2026 10:10:00 AM to Downtown Bus Station, Chicago (USA) arriving at 3/27/2026 3:15:00 PM. 50 Economy ticket for $57 per person are available. Travel duration is 6h 5m
Greyhound US	6h 40m	8:00 AM	Louisville, KY	Greyhound Bus Station	1:40 PM	Chicago	95th Red Line Station	Economy	$59	A Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 3/27/2026 8:00:00 AM to 95th Red Line Station, Chicago (USA) arriving at 3/27/2026 1:40:00 PM. 50 Economy ticket for $59 per person are available. Travel duration is 6h 40m
Greyhound US	7h 10m	8:00 AM	Louisville, KY	Greyhound Bus Station	2:10 PM	Chicago	Canal & Van Buren	Economy	$59	A Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 3/27/2026 8:00:00 AM to Canal & Van Buren, Chicago (USA) arriving at 3/27/2026 2:10:00 PM. 50 Economy ticket for $59 per person are available. Travel duration is 7h 10m
FlixBus	5h 20m	7:30 PM	Louisville, KY	Greyhound Bus Station	11:50 PM	Chicago	95th Red Line Station	Economy	$60	A Bus from FlixBus goes from Greyhound Bus Station, Louisville, KY (USA) at 3/27/2026 7:30:00 PM to 95th Red Line Station, Chicago (USA) arriving at 3/27/2026 11:50:00 PM. 50 Economy ticket for $60 per person are available. Travel duration is 5h 20m
FlixBus	5h 40m	7:30 PM	Louisville, KY	Greyhound Bus Station	12:10 AM	Chicago	Downtown Bus Station	Economy	$61	A Bus from FlixBus goes from Greyhound Bus Station, Louisville, KY (USA) at 3/27/2026 7:30:00 PM to Downtown Bus Station, Chicago (USA) arriving at 3/28/2026 12:10:00 AM. 50 Economy ticket for $61 per person are available. Travel duration is 5h 40m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	6h 40m	8:00 AM	Louisville, KY	Greyhound Bus Station	1:40 PM	Chicago	95th Red Line Station	Economy	$39	A Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 3/28/2026 8:00:00 AM to 95th Red Line Station, Chicago (USA) arriving at 3/28/2026 1:40:00 PM. 50 Economy ticket for $39 per person are available. Travel duration is 6h 40m
Greyhound US	6h 10m	2:50 AM	Louisville, KY	Greyhound Bus Station	8:00 AM	Chicago	Canal & Van Buren	Economy	$42	A Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 3/28/2026 2:50:00 AM to Canal & Van Buren, Chicago (USA) arriving at 3/28/2026 8:00:00 AM. 50 Economy ticket for $42 per person are available. Travel duration is 6h 10m
Greyhound US	7h 10m	8:00 AM	Louisville, KY	Greyhound Bus Station	2:10 PM	Chicago	Canal & Van Buren	Economy	$42	A Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 3/28/2026 8:00:00 AM to Canal & Van Buren, Chicago (USA) arriving at 3/28/2026 2:10:00 PM. 50 Economy ticket for $42 per person are available. Travel duration is 7h 10m
FlixBus	5h 20m	7:30 PM	Louisville, KY	Greyhound Bus Station	11:50 PM	Chicago	95th Red Line Station	Economy	$42	A Bus from FlixBus goes from Greyhound Bus Station, Louisville, KY (USA) at 3/28/2026 7:30:00 PM to 95th Red Line Station, Chicago (USA) arriving at 3/28/2026 11:50:00 PM. 50 Economy ticket for $42 per person are available. Travel duration is 5h 20m
FlixBus	7h 40m	4:50 AM	Louisville, KY	Greyhound Bus Station	11:30 AM	Chicago	Downtown Bus Station	Economy	$45	A Bus from FlixBus goes from Greyhound Bus Station, Louisville, KY (USA) at 3/28/2026 4:50:00 AM to Downtown Bus Station, Chicago (USA) arriving at 3/28/2026 11:30:00 AM. 50 Economy ticket for $45 per person are available. Travel duration is 7h 40m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	6h 35m	2:50 AM	Louisville, KY	Greyhound Bus Station	8:25 AM	Chicago	Downtown Bus Station	Economy	$40	A Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 3/29/2026 2:50:00 AM to Downtown Bus Station, Chicago (USA) arriving at 3/29/2026 8:25:00 AM. 50 Economy ticket for $40 per person are available. Travel duration is 6h 35m
Greyhound US	7h 35m	8:00 AM	Louisville, KY	Greyhound Bus Station	2:35 PM	Chicago	Downtown Bus Station	Economy	$40	A Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 3/29/2026 8:00:00 AM to Downtown Bus Station, Chicago (USA) arriving at 3/29/2026 2:35:00 PM. 50 Economy ticket for $40 per person are available. Travel duration is 7h 35m
Greyhound US	6h 35m	2:35 PM	Louisville, KY	Greyhound Bus Station	8:10 PM	Chicago	Downtown Bus Station	Economy	$40	A Bus from Greyhound US goes from Greyhound Bus Station, Louisville, KY (USA) at 3/29/2026 2:35:00 PM to Downtown Bus Station, Chicago (USA) arriving at 3/29/2026 8:10:00 PM. 50 Economy ticket for $40 per person are available. Travel duration is 6h 35m
FlixBus	5h 40m	7:30 PM	Louisville, KY	Greyhound Bus Station	12:10 AM	Chicago	Downtown Bus Station	Economy	$43	A Bus from FlixBus goes from Greyhound Bus Station, Louisville, KY (USA) at 3/29/2026 7:30:00 PM to Downtown Bus Station, Chicago (USA) arriving at 3/30/2026 12:10:00 AM. 50 Economy ticket for $43 per person are available. Travel duration is 5h 40m
FlixBus	5h 20m	7:30 PM	Louisville, KY	Greyhound Bus Station	11:50 PM	Chicago	95th Red Line Station	Economy	$45	A Bus from FlixBus goes from Greyhound Bus Station, Louisville, KY (USA) at 3/29/2026 7:30:00 PM to 95th Red Line Station, Chicago (USA) arriving at 3/29/2026 11:50:00 PM. 50 Economy ticket for $45 per person are available. Travel duration is 5h 20m

Best Price Offer: The price for the cheapest bus from Louisville, KY to Chicago is $31 on 3/25/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Louisville, KY and Chicago

See here how frequent the connections between Louisville, KY and Chicago are, during different times and days of the week.

Tuesday is the busiest day, with more than 28 daily buses from Louisville, KY to Chicago. Wednesday has instead the fewest connections, with only 14 daily coaches between Louisville, KY and Chicago.

The busiest time of the day is the Morning, with 37 buses from Louisville, KY to Chicago, while Afternoon sees the fewest connections between Louisville, KY and Chicago, with 15 offers.

Facts about the bus from Louisville, KY to Chicago

Compare all providers like Greyhound US and FlixBus that travel 20 times every day by bus from Louisville, KY to Chicago in one click! Book your bus ticket from Louisville, KY to Chicago starting from $31!

Cheapest Bus	$31
Fastest Bus	4h 20m
Earliest Bus	2:50 AM
Latest Bus	7:30 PM
Daily Bus Routes	20 Ø
Distance	269.3 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from Louisville, KY to Chicago

Every day, 20 buses from 2 bus companies leave Louisville, KY for Chicago: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 03/24/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 03/22

Monday 03/23

Tuesday 03/24

$55

Wednesday 03/25

$32

Thursday 03/26

Friday 03/27

$57

Saturday 03/28

$39

Sunday 03/29

$49

Monday 03/30

Tuesday 03/31

$43

Wednesday 04/01

$47

Thursday 04/02

$49

Friday 04/03

Saturday 04/04

$47

Sunday 04/05

Monday 04/06

$45

Tuesday 04/07

$39

Wednesday 04/08

Thursday 04/09

$42

Friday 04/10

$46

Saturday 04/11

$39

Sunday 04/12

$46

Monday 04/13

$39

Tuesday 04/14

$37

Wednesday 04/15

$41

Thursday 04/16

$42

Friday 04/17

$40

Saturday 04/18

The cheapest time to travel from Louisville, KY to Chicago

See here on which day and which time of the day you can find the cheapest bus ticket from Louisville, KY to Chicago, for the next 30 days.

With a price starting from $31, Wednesday is the cheapest day for a bus from Louisville, KY to Chicago. Sunday instead is the most expensive day with prices starting from $40.

Morning is the cheapest day time for bus tickets from Louisville, KY to Chicago, with $31. Evening is the most expensive time of the day with prices starting from $35.

How to save money travelling from Louisville, KY to Chicago

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Louisville, KY to Chicago in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Louisville, KY to Chicago, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Louisville, KY to Chicago are also emptier.

Beloved bus companies from Louisville, KY to Chicago

These are the most booked bus companies between Louisville, KY to Chicago from our users.

Greyhound US from Louisville, KY to Chicago

Here you will find the key facts about the Greyhound US bus route Louisville, KY to Chicago:

Cheapest Price	$31
Fastest Bus	5h 5m
Earliest Bus	2:50 AM
Last Bus	2:35 PM
Daily Connections	14 Ø
Found on	3/23/2026

FlixBus from Louisville, KY to Chicago

Here you will find the key facts about the FlixBus bus route Louisville, KY to Chicago:

Cheapest Price	$35
Fastest Bus	4h 20m
Earliest Bus	4:50 AM
Last Bus	7:30 PM
Daily Connections	6 Ø
Found on	3/23/2026

All bus stations and stops in Louisville, KY and Chicago

In the map below, you can see where to find all bus stations in Louisville, KY and Chicago.

Greyhound Bus Station

W Muhammad Ali Blvd 720

Convention Center

S 3rd St 300

BP Gas Station

Newburg Rd 3301

W Muhammad Ali Blvd

East Broadway, under the I-65 overpass between S 1st Street and S Brook Street

International Airport

95th Red Line Station

W. 95th St 14

Downtown Bus Station

West Harrison Street 630-670

Union Station

S Canal St 225

Cumberland CTA

N Cumberland Ave 5800

Canal & Van Buren

S Canal St 310-320

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Louisville, KY to Chicago? Compare all modes of transports from Louisville, KY to Chicago.

Service and Comfort on the bus from Louisville, KY to Chicago

Want to know which seat classes are available on the buses from Louisville, KY to Chicago? Or which bus companies serve the route Louisville, KY to Chicago? Below you will find answers to your questions.

FAQs about the Louisville, KY to Chicago bus

How much does a Louisville, KY Chicago bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $31 and takes 6h 35m to reach Chicago. Compare offers to save money!

How much could I save by comparing buses from Louisville, KY to Chicago?

This route is offered by 2 companies with a range of ticket prices between $31 and $100. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Chicago.

On average, how many connections are available from Louisville, KY to Chicago each day?

Every day, the Louisville, KY to Chicago bus route is served by approximately 20 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Louisville, KY to Chicago take?

The fastest bus from Louisville, KY to Chicago is offered by FlixBus and takes 4h 20m. Bus tickets for this connection cost $59. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Louisville, KY to Chicago?

The earliest bus arriving in Chicago from Louisville, KY starts at 2:50 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Louisville, KY to Chicago?

The latest bus trip departing from Louisville, KY for Chicago starts at 7:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Louisville, KY Chicago route?

When traveling by bus from Louisville, KY to Chicago, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Louisville, KY and Chicago?

You can check all the direct connections between Louisville, KY and Chicago by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Louisville, KY to Chicago bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Louisville, KY Chicago bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Louisville, KY Chicago bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Louisville, KY to Chicago on your planned travel date.

How does CheckMyBus find the best bus deals from Louisville, KY to Chicago?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 20 daily trips between Louisville, KY and Chicago. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Louisville, KY to Chicago?

Prices and availability for 20 trips between Louisville, KY and Chicago change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Louisville, KY to Chicago

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Louisville, KY and to Chicago

Here’s an overview of the most popular bus routes to Louisville, KY and to Chicago. Simply click on the connection of your choice, and you will find all the details about your bus route!