How to get from Mesa, AZ to San Diego

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What is the best way to travel from Mesa, AZ to San Diego?

Looking for a trip? Compare all the available Buses and Flights for the journey to San Diego from Mesa, AZ. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 1 available companies to find your perfect trip!
Flight is the cheapest and fastest way on this route
Transport type
Travel time
Cheapest price
Average price
Daily departures
Bus
7h 10m
$62
$97
12
Flight
1h 8m
$48
$214
17

What is the cheapest way to reach San Diego from Mesa, AZ?

You can get to San Diego with just $48 by taking a Flight from Frontier Airlines, but you can find many more cheap offers: we have selected the best ones for next few days here for you.

Thursday
from $74
Friday
from $60
Saturday
from $48
Sunday
from $64
Monday
from $59
Tuesday
from $62
Wednesday
from $72

    Cheapest Buses Thursday

  • Greyhound US
    14h 30m
    0
    8:10 PM
    Mesa, AZ
    Greyhound
    10:40 AM
    San Diego
    Seaport Village
    0
    Greyhound US
    Economy
    $74
  • Greyhound US
    13h 20m
    0
    8:10 PM
    Mesa, AZ
    Greyhound
    9:30 AM
    San Diego
    Old Town Transit Center
    0
    Greyhound US
    Economy
    $74
  • Desert bus Lines
    7h 10m
    0
    1:00 PM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    8:10 PM
    San Diego
    Old Town Transit Center
    0
    Desert bus Lines
    Premium Economy
    $135
  • FlixBus
    13h 30m
    0
    8:00 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    9:30 PM
    San Diego
    Seaport Village
    0
    FlixBus
    Economy
    $145
  • FlixBus
    10h 10m
    0
    8:00 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    6:10 PM
    San Diego
    Old Town Transit Center
    0
    FlixBus
    Economy
    $145
  • Cheapest Flights Thursday

  • Frontier Airlines
    1h 18m
    0
    1:00 PM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    2:18 PM
    San Diego Airport
    San Diego Airport
    0
    Frontier Airlines
    Economy
    from $197
  • American Airlines
    1h 20m
    0
    7:30 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    8:50 AM
    San Diego Airport
    San Diego Airport
    0
    American Airlines
    Economy
    from $264
  • American Airlines
    1h 9m
    0
    6:20 PM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    7:29 PM
    San Diego Airport
    San Diego Airport
    0
    American Airlines
    Economy
    from $264
  • American Airlines
    1h 13m
    0
    8:35 PM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    9:48 PM
    San Diego Airport
    San Diego Airport
    0
    American Airlines
    Economy
    from $264

    Cheapest Flights Friday

  • Frontier Airlines
    1h 12m
    0
    3:46 PM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    4:58 PM
    San Diego Airport
    San Diego Airport
    0
    Frontier Airlines
    Economy
    from $60
  • Frontier Airlines
    1h 14m
    0
    6:30 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    7:44 AM
    San Diego Airport
    San Diego Airport
    0
    Frontier Airlines
    Economy
    from $116
  • American Airlines
    1h 8m
    0
    2:11 PM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    3:19 PM
    San Diego Airport
    San Diego Airport
    0
    American Airlines
    Economy
    from $171
  • American Airlines
    1h 20m
    0
    7:30 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    8:50 AM
    San Diego Airport
    San Diego Airport
    0
    American Airlines
    Economy
    from $182
  • American Airlines
    1h 13m
    0
    10:38 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    11:51 AM
    San Diego Airport
    San Diego Airport
    0
    American Airlines
    Economy
    from $213
  • Volaris
    15h 19m
    0
    9:32 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    12:51 AM
    Tijuana Airport
    Tijuana Airport
    0
    Volaris
    Economy
    from $408
  • Cheapest Buses Friday

  • FlixBus
    13h 30m
    0
    8:00 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    9:30 PM
    San Diego
    Seaport Village
    0
    FlixBus
    Economy
    $70
  • FlixBus
    10h 10m
    0
    8:00 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    6:10 PM
    San Diego
    Old Town Transit Center
    0
    FlixBus
    Economy
    $70
  • Desert bus Lines
    7h 10m
    0
    1:00 PM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    8:10 PM
    San Diego
    Old Town Transit Center
    0
    Desert bus Lines
    Premium Economy
    $135

    Cheapest Flights Saturday

  • Frontier Airlines
    1h 12m
    0
    3:46 PM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    4:58 PM
    San Diego Airport
    San Diego Airport
    0
    Frontier Airlines
    Economy
    from $48
  • American Airlines
    1h 17m
    0
    7:39 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    8:56 AM
    San Diego Airport
    San Diego Airport
    0
    American Airlines
    Economy
    from $103
  • American Airlines
    1h 14m
    0
    2:11 PM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    3:25 PM
    San Diego Airport
    San Diego Airport
    0
    American Airlines
    Economy
    from $103
  • American Airlines
    1h 10m
    0
    6:08 PM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    7:18 PM
    San Diego Airport
    San Diego Airport
    0
    American Airlines
    Economy
    from $103
  • Cheapest Buses Saturday

  • FlixBus
    13h 30m
    0
    8:00 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    9:30 PM
    San Diego
    Seaport Village
    0
    FlixBus
    Economy
    $100
  • FlixBus
    10h 10m
    0
    8:00 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    6:10 PM
    San Diego
    Old Town Transit Center
    0
    FlixBus
    Economy
    $101
  • Greyhound US
    19h 30m
    0
    8:10 PM
    Mesa, AZ
    Greyhound
    3:40 PM
    San Diego
    SDSU Transit Center
    0
    Greyhound US
    Economy
    $122
  • Greyhound US
    12h 35m
    0
    8:10 PM
    Mesa, AZ
    Greyhound
    8:45 AM
    San Diego
    La Jolla Village
    0
    Greyhound US
    Economy
    $123
  • Desert bus Lines
    7h 10m
    0
    1:00 PM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    8:10 PM
    San Diego
    Old Town Transit Center
    0
    Desert bus Lines
    Premium Economy
    $135

    Cheapest Flights Sunday

  • Frontier Airlines
    1h 16m
    0
    6:30 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    7:46 AM
    San Diego Airport
    San Diego Airport
    0
    Frontier Airlines
    Economy
    from $64
  • Frontier Airlines
    1h 12m
    0
    3:46 PM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    4:58 PM
    San Diego Airport
    San Diego Airport
    0
    Frontier Airlines
    Economy
    from $64
  • American Airlines
    1h 17m
    0
    7:39 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    8:56 AM
    San Diego Airport
    San Diego Airport
    0
    American Airlines
    Economy
    from $170
  • American Airlines
    1h 14m
    0
    2:11 PM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    3:25 PM
    San Diego Airport
    San Diego Airport
    0
    American Airlines
    Economy
    from $170
  • American Airlines
    1h 10m
    0
    6:08 PM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    7:18 PM
    San Diego Airport
    San Diego Airport
    0
    American Airlines
    Economy
    from $170
  • Cheapest Buses Sunday

  • FlixBus
    13h 30m
    0
    8:00 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    9:30 PM
    San Diego
    Seaport Village
    0
    FlixBus
    Economy
    $75
  • FlixBus
    10h 10m
    0
    8:00 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    6:10 PM
    San Diego
    Old Town Transit Center
    0
    FlixBus
    Economy
    $75
  • Greyhound US
    13h 5m
    0
    8:10 PM
    Mesa, AZ
    Greyhound
    9:15 AM
    San Diego
    Old Town Transit Center
    0
    Greyhound US
    Economy
    $89
  • Greyhound US
    14h 30m
    0
    8:10 PM
    Mesa, AZ
    Greyhound
    10:40 AM
    San Diego
    Seaport Village
    0
    Greyhound US
    Economy
    $90
  • Desert bus Lines
    7h 10m
    0
    1:00 PM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    8:10 PM
    San Diego
    Old Town Transit Center
    0
    Desert bus Lines
    Premium Economy
    $142

    Cheapest Flights Monday

  • Frontier Airlines
    1h 16m
    0
    6:30 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    7:46 AM
    San Diego Airport
    San Diego Airport
    0
    Frontier Airlines
    Economy
    from $59
  • Frontier Airlines
    1h 12m
    0
    3:46 PM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    4:58 PM
    San Diego Airport
    San Diego Airport
    0
    Frontier Airlines
    Economy
    from $59
  • American Airlines
    1h 17m
    0
    7:39 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    8:56 AM
    San Diego Airport
    San Diego Airport
    0
    American Airlines
    Economy
    from $170
  • American Airlines
    1h 12m
    0
    10:36 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    11:48 AM
    San Diego Airport
    San Diego Airport
    0
    American Airlines
    Economy
    from $170
  • JetBlue Airways
    1h 15m
    0
    7:00 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    8:15 AM
    San Diego Airport
    San Diego Airport
    0
    JetBlue Airways
    Economy
    from $302
  • Aeroméxico
    10h 15m
    0
    1:10 PM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    11:25 PM
    Tijuana Airport
    Tijuana Airport
    0
    Aeroméxico
    Economy
    from $338
  • Cheapest Buses Monday

  • FlixBus
    10h 10m
    0
    8:00 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    6:10 PM
    San Diego
    Old Town Transit Center
    0
    FlixBus
    Economy
    $66
  • FlixBus
    13h 30m
    0
    8:00 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    9:30 PM
    San Diego
    Seaport Village
    0
    FlixBus
    Economy
    $67
  • Greyhound US
    13h 20m
    0
    8:10 PM
    Mesa, AZ
    Greyhound
    9:30 AM
    San Diego
    Old Town Transit Center
    0
    Greyhound US
    Economy
    $80
  • Greyhound US
    13h 5m
    0
    8:10 PM
    Mesa, AZ
    Greyhound
    9:15 AM
    San Diego
    Old Town Transit Center
    0
    Greyhound US
    Economy
    $81
  • Desert bus Lines
    7h 10m
    0
    1:00 PM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    8:10 PM
    San Diego
    Old Town Transit Center
    0
    Desert bus Lines
    Premium Economy
    $135

    Cheapest Buses Tuesday

  • FlixBus
    13h 30m
    0
    8:00 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    9:30 PM
    San Diego
    Seaport Village
    0
    FlixBus
    Economy
    $62
  • FlixBus
    10h 10m
    0
    8:00 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    6:10 PM
    San Diego
    Old Town Transit Center
    0
    FlixBus
    Economy
    $62
  • Greyhound US
    12h 35m
    0
    8:10 PM
    Mesa, AZ
    Greyhound
    8:45 AM
    San Diego
    La Jolla Village
    0
    Greyhound US
    Economy
    $83
  • Greyhound US
    13h 5m
    0
    8:10 PM
    Mesa, AZ
    Greyhound
    9:15 AM
    San Diego
    Old Town Transit Center
    0
    Greyhound US
    Economy
    $84
  • Desert bus Lines
    7h 10m
    0
    1:00 PM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    8:10 PM
    San Diego
    Old Town Transit Center
    0
    Desert bus Lines
    Premium Economy
    $135

    Cheapest Buses Wednesday

  • Greyhound US
    13h 55m
    0
    8:10 PM
    Mesa, AZ
    Greyhound
    10:05 AM
    San Diego
    San Ysidro Transit Center
    0
    Greyhound US
    Economy
    $72

What are the fastest trips from Mesa, AZ to San Diego?

You can get to San Diego from Mesa, AZ in just 1h 8m with a Flight from American Airlines. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.

Thursday
from 1h 9m
Friday
from 1h 8m
Saturday
from 1h 10m
Sunday
from 1h 10m
Monday
from 1h 12m
Tuesday
from 7h 10m
Wednesday
from 13h 55m

    Fastest Flights Thursday

  • American Airlines
    1h 9m
    0
    6:20 PM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    7:29 PM
    San Diego Airport
    San Diego Airport
    0
    American Airlines
    Economy
    from $264
  • American Airlines
    1h 13m
    0
    8:35 PM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    9:48 PM
    San Diego Airport
    San Diego Airport
    0
    American Airlines
    Economy
    from $264
  • Frontier Airlines
    1h 18m
    0
    1:00 PM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    2:18 PM
    San Diego Airport
    San Diego Airport
    0
    Frontier Airlines
    Economy
    from $197
  • American Airlines
    1h 20m
    0
    7:30 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    8:50 AM
    San Diego Airport
    San Diego Airport
    0
    American Airlines
    Economy
    from $264
  • Fastest Buses Thursday

  • Desert bus Lines
    7h 10m
    0
    1:00 PM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    8:10 PM
    San Diego
    Old Town Transit Center
    0
    Desert bus Lines
    Premium Economy
    $135
  • FlixBus
    10h 10m
    0
    8:00 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    6:10 PM
    San Diego
    Old Town Transit Center
    0
    FlixBus
    Economy
    $145
  • Greyhound US
    13h 20m
    0
    8:10 PM
    Mesa, AZ
    Greyhound
    9:30 AM
    San Diego
    Old Town Transit Center
    0
    Greyhound US
    Economy
    $74
  • FlixBus
    13h 30m
    0
    8:00 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    9:30 PM
    San Diego
    Seaport Village
    0
    FlixBus
    Economy
    $145
  • Greyhound US
    14h 30m
    0
    8:10 PM
    Mesa, AZ
    Greyhound
    10:40 AM
    San Diego
    Seaport Village
    0
    Greyhound US
    Economy
    $74

    Fastest Flights Friday

  • American Airlines
    1h 8m
    0
    2:11 PM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    3:19 PM
    San Diego Airport
    San Diego Airport
    0
    American Airlines
    Economy
    from $171
  • Frontier Airlines
    1h 12m
    0
    3:46 PM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    4:58 PM
    San Diego Airport
    San Diego Airport
    0
    Frontier Airlines
    Economy
    from $60
  • American Airlines
    1h 13m
    0
    10:38 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    11:51 AM
    San Diego Airport
    San Diego Airport
    0
    American Airlines
    Economy
    from $213
  • Frontier Airlines
    1h 14m
    0
    6:30 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    7:44 AM
    San Diego Airport
    San Diego Airport
    0
    Frontier Airlines
    Economy
    from $116
  • American Airlines
    1h 20m
    0
    7:30 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    8:50 AM
    San Diego Airport
    San Diego Airport
    0
    American Airlines
    Economy
    from $182
  • Volaris
    8h 32m
    0
    9:32 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    6:04 PM
    Tijuana Airport
    Tijuana Airport
    0
    Volaris
    Economy
    from $442
  • Fastest Buses Friday

  • Desert bus Lines
    7h 10m
    0
    1:00 PM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    8:10 PM
    San Diego
    Old Town Transit Center
    0
    Desert bus Lines
    Premium Economy
    $135
  • FlixBus
    10h 10m
    0
    8:00 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    6:10 PM
    San Diego
    Old Town Transit Center
    0
    FlixBus
    Economy
    $70
  • FlixBus
    13h 30m
    0
    8:00 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    9:30 PM
    San Diego
    Seaport Village
    0
    FlixBus
    Economy
    $70

    Fastest Flights Saturday

  • American Airlines
    1h 10m
    0
    6:08 PM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    7:18 PM
    San Diego Airport
    San Diego Airport
    0
    American Airlines
    Economy
    from $103
  • Frontier Airlines
    1h 12m
    0
    3:46 PM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    4:58 PM
    San Diego Airport
    San Diego Airport
    0
    Frontier Airlines
    Economy
    from $48
  • American Airlines
    1h 14m
    0
    2:11 PM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    3:25 PM
    San Diego Airport
    San Diego Airport
    0
    American Airlines
    Economy
    from $103
  • American Airlines
    1h 17m
    0
    7:39 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    8:56 AM
    San Diego Airport
    San Diego Airport
    0
    American Airlines
    Economy
    from $103
  • Fastest Buses Saturday

  • Desert bus Lines
    7h 10m
    0
    1:00 PM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    8:10 PM
    San Diego
    Old Town Transit Center
    0
    Desert bus Lines
    Premium Economy
    $135
  • FlixBus
    10h 10m
    0
    8:00 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    6:10 PM
    San Diego
    Old Town Transit Center
    0
    FlixBus
    Economy
    $101
  • Greyhound US
    12h 35m
    0
    8:10 PM
    Mesa, AZ
    Greyhound
    8:45 AM
    San Diego
    La Jolla Village
    0
    Greyhound US
    Economy
    $123
  • FlixBus
    13h 30m
    0
    8:00 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    9:30 PM
    San Diego
    Seaport Village
    0
    FlixBus
    Economy
    $100
  • Greyhound US
    19h 30m
    0
    8:10 PM
    Mesa, AZ
    Greyhound
    3:40 PM
    San Diego
    SDSU Transit Center
    0
    Greyhound US
    Economy
    $122

    Fastest Flights Sunday

  • American Airlines
    1h 10m
    0
    6:08 PM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    7:18 PM
    San Diego Airport
    San Diego Airport
    0
    American Airlines
    Economy
    from $170
  • Frontier Airlines
    1h 12m
    0
    3:46 PM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    4:58 PM
    San Diego Airport
    San Diego Airport
    0
    Frontier Airlines
    Economy
    from $64
  • American Airlines
    1h 14m
    0
    2:11 PM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    3:25 PM
    San Diego Airport
    San Diego Airport
    0
    American Airlines
    Economy
    from $170
  • Frontier Airlines
    1h 16m
    0
    6:30 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    7:46 AM
    San Diego Airport
    San Diego Airport
    0
    Frontier Airlines
    Economy
    from $64
  • American Airlines
    1h 17m
    0
    7:39 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    8:56 AM
    San Diego Airport
    San Diego Airport
    0
    American Airlines
    Economy
    from $170
  • Fastest Buses Sunday

  • Desert bus Lines
    7h 10m
    0
    1:00 PM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    8:10 PM
    San Diego
    Old Town Transit Center
    0
    Desert bus Lines
    Premium Economy
    $142
  • FlixBus
    10h 10m
    0
    8:00 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    6:10 PM
    San Diego
    Old Town Transit Center
    0
    FlixBus
    Economy
    $75
  • Greyhound US
    13h 5m
    0
    8:10 PM
    Mesa, AZ
    Greyhound
    9:15 AM
    San Diego
    Old Town Transit Center
    0
    Greyhound US
    Economy
    $89
  • FlixBus
    13h 30m
    0
    8:00 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    9:30 PM
    San Diego
    Seaport Village
    0
    FlixBus
    Economy
    $75
  • Greyhound US
    14h 30m
    0
    8:10 PM
    Mesa, AZ
    Greyhound
    10:40 AM
    San Diego
    Seaport Village
    0
    Greyhound US
    Economy
    $90

    Fastest Flights Monday

  • Frontier Airlines
    1h 12m
    0
    3:46 PM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    4:58 PM
    San Diego Airport
    San Diego Airport
    0
    Frontier Airlines
    Economy
    from $59
  • American Airlines
    1h 12m
    0
    10:36 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    11:48 AM
    San Diego Airport
    San Diego Airport
    0
    American Airlines
    Economy
    from $170
  • JetBlue Airways
    1h 15m
    0
    7:00 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    8:15 AM
    San Diego Airport
    San Diego Airport
    0
    JetBlue Airways
    Economy
    from $302
  • Frontier Airlines
    1h 16m
    0
    6:30 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    7:46 AM
    San Diego Airport
    San Diego Airport
    0
    Frontier Airlines
    Economy
    from $59
  • American Airlines
    1h 17m
    0
    7:39 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    8:56 AM
    San Diego Airport
    San Diego Airport
    0
    American Airlines
    Economy
    from $170
  • Volaris
    9h 33m
    0
    9:32 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    7:05 PM
    Tijuana Airport
    Tijuana Airport
    0
    Volaris
    Economy
    from $357
  • Fastest Buses Monday

  • Desert bus Lines
    7h 10m
    0
    1:00 PM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    8:10 PM
    San Diego
    Old Town Transit Center
    0
    Desert bus Lines
    Premium Economy
    $135
  • FlixBus
    10h 10m
    0
    8:00 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    6:10 PM
    San Diego
    Old Town Transit Center
    0
    FlixBus
    Economy
    $66
  • Greyhound US
    13h 5m
    0
    8:10 PM
    Mesa, AZ
    Greyhound
    9:15 AM
    San Diego
    Old Town Transit Center
    0
    Greyhound US
    Economy
    $81
  • Greyhound US
    13h 20m
    0
    8:10 PM
    Mesa, AZ
    Greyhound
    9:30 AM
    San Diego
    Old Town Transit Center
    0
    Greyhound US
    Economy
    $80
  • FlixBus
    13h 30m
    0
    8:00 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    9:30 PM
    San Diego
    Seaport Village
    0
    FlixBus
    Economy
    $67

    Fastest Buses Tuesday

  • Desert bus Lines
    7h 10m
    0
    1:00 PM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    8:10 PM
    San Diego
    Old Town Transit Center
    0
    Desert bus Lines
    Premium Economy
    $135
  • FlixBus
    10h 10m
    0
    8:00 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    6:10 PM
    San Diego
    Old Town Transit Center
    0
    FlixBus
    Economy
    $62
  • Greyhound US
    12h 35m
    0
    8:10 PM
    Mesa, AZ
    Greyhound
    8:45 AM
    San Diego
    La Jolla Village
    0
    Greyhound US
    Economy
    $83
  • Greyhound US
    13h 5m
    0
    8:10 PM
    Mesa, AZ
    Greyhound
    9:15 AM
    San Diego
    Old Town Transit Center
    0
    Greyhound US
    Economy
    $84
  • FlixBus
    13h 30m
    0
    8:00 AM
    Phoenix Sky Harbor Airport
    Phoenix Sky Harbor Airport
    9:30 PM
    San Diego
    Seaport Village
    0
    FlixBus
    Economy
    $62

    Fastest Buses Wednesday

  • Greyhound US
    13h 55m
    0
    8:10 PM
    Mesa, AZ
    Greyhound
    10:05 AM
    San Diego
    San Ysidro Transit Center
    0
    Greyhound US
    Economy
    $72
Here you will find all operators and timetables for a Bus from Mesa, AZ to San Diego

What are the most popular stations in Mesa, AZ and San Diego?

In Mesa, AZ, you will usually depart from Greyhound or Fry’s Fuel Center, while in San Diego you will be arriving at Santa Fe Depot, San Ysidro Transit Center or Old Town Transit Center, but there are many more stops to explore in both locations.

How do I decide? Some tips and tricks from our experience

Are you having trouble deciding on how to get to San Diego from Mesa, AZ? With 8 connections between 1 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.

Look for the lowest price

Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Mesa, AZ and San Diego, you can pay as low as $48 with a Flight from Frontier Airlines.

Travel duration

Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from American Airlines: you will get to San Diego in just 1h 8m.

Comfort makes all the difference

You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Mesa, AZ and San Diego are American Airlines, FlixBus and Greyhound US, but be sure to check what they have to offer!

Save money with deals, and always compare

One last tip? Even if you live in Mesa, AZ and San Diego is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Tempe, AZ or to San Diego Airport, and look at flights from Phoenix Sky Harbor Airport, and landing at Tijuana Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!

Which companies offer a trip from Mesa, AZ to San Diego?

The most popular companies between Mesa, AZ and San Diego, are American Airlines, FlixBus and Greyhound US. Be sure to check their seat class offers and the amenities that they provide.

Bus companies: FlixBus, Greyhound US and Desert bus Lines

Airlines: American Airlines, Frontier Airlines, Volaris and 2 more.

All you need to know when you travel from Mesa, AZ to San Diego

Check all information on comfort and services on all modes of transports from Mesa, AZ to San Diego. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.

FAQs about the trip from Mesa, AZ to San Diego

How can I reach San Diego from Mesa, AZ?

Every day, there are on average 8 connections between Bus and Flight, with which you can get to San Diego from Mesa, AZ.

How far is San Diego from Mesa, AZ?

The distance between Mesa, AZ and San Diego is 311.8 miles.

What is the most ecofriendly mode of transport between Mesa, AZ and San Diego?

Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance. On this particular route, a bus will emit, per person, a total of 14 kgs of CO2, a train 18 kgs, a car 85 kgs, and a flight 123 kgs.

What is the cheapest mode of transport from Mesa, AZ to San Diego?

You can get to San Diego with just $48 by taking a Flight from Frontier Airlines.

What is the fastest way to get from Mesa, AZ to San Diego?

While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to San Diego in just 1h 8m with a Flight from American Airlines.

More routes to Mesa, AZ and to San Diego

Looking for more options? Here you can see the most popular routes to Mesa, AZ and to San Diego. Simply click on a connection, and you’ll find all the details about the route!

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