What is the best way to travel from Mesa, AZ to San Diego?
Looking for a trip? Compare all the available Buses and Flights for the journey to San Diego from Mesa, AZ. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 1 available companies to find your perfect trip!
What is the cheapest way to reach San Diego from Mesa, AZ?
You can get to San Diego with just $48 by taking a Flight from Frontier Airlines, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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Greyhound US14h 30m08:10 PMMesa, AZGreyhound10:40 AMSan DiegoSeaport Village0EconomyA Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 7/3/2025 8:10:00 PM to Seaport Village, San Diego (USA) arriving at 7/4/2025 10:40:00 AM. 50 Economy ticket for $74 per person are available. Travel duration is 14h 30m
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Greyhound US13h 20m08:10 PMMesa, AZGreyhound9:30 AMSan DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 7/3/2025 8:10:00 PM to Old Town Transit Center, San Diego (USA) arriving at 7/4/2025 9:30:00 AM. 50 Economy ticket for $74 per person are available. Travel duration is 13h 20m
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Desert bus Lines7h 10m01:00 PMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport8:10 PMSan DiegoOld Town Transit Center0Premium EconomyA Bus from Desert bus Lines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/3/2025 1:00:00 PM to Old Town Transit Center, San Diego (USA) arriving at 7/3/2025 8:10:00 PM. 50 Premium Economy ticket for $135 per person are available. Travel duration is 7h 10m
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FlixBus13h 30m08:00 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport9:30 PMSan DiegoSeaport Village0EconomyA Bus from FlixBus goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/3/2025 8:00:00 AM to Seaport Village, San Diego (USA) arriving at 7/3/2025 9:30:00 PM. 50 Economy ticket for $145 per person are available. Travel duration is 13h 30m
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FlixBus10h 10m08:00 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport6:10 PMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/3/2025 8:00:00 AM to Old Town Transit Center, San Diego (USA) arriving at 7/3/2025 6:10:00 PM. 50 Economy ticket for $145 per person are available. Travel duration is 10h 10m
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Frontier Airlines1h 18m01:00 PMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport2:18 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/3/2025 1:00:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 7/3/2025 2:18:00 PM. 50 Economy ticket for $197 per person are available. Travel duration is 1h 18m
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American Airlines1h 20m07:30 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport8:50 AMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/3/2025 7:30:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 7/3/2025 8:50:00 AM. 50 Economy ticket for $264 per person are available. Travel duration is 1h 20m
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American Airlines1h 9m06:20 PMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport7:29 PMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/3/2025 6:20:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 7/3/2025 7:29:00 PM. 50 Economy ticket for $264 per person are available. Travel duration is 1h 9m
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American Airlines1h 13m08:35 PMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport9:48 PMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/3/2025 8:35:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 7/3/2025 9:48:00 PM. 50 Economy ticket for $264 per person are available. Travel duration is 1h 13m
Cheapest Buses Thursday
Cheapest Flights Thursday
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Frontier Airlines1h 12m03:46 PMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport4:58 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/4/2025 3:46:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 7/4/2025 4:58:00 PM. 50 Economy ticket for $60 per person are available. Travel duration is 1h 12m
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Frontier Airlines1h 14m06:30 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport7:44 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/4/2025 6:30:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 7/4/2025 7:44:00 AM. 50 Economy ticket for $116 per person are available. Travel duration is 1h 14m
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American Airlines1h 8m02:11 PMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport3:19 PMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/4/2025 2:11:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 7/4/2025 3:19:00 PM. 50 Economy ticket for $171 per person are available. Travel duration is 1h 8m
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American Airlines1h 20m07:30 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport8:50 AMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/4/2025 7:30:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 7/4/2025 8:50:00 AM. 50 Economy ticket for $182 per person are available. Travel duration is 1h 20m
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American Airlines1h 13m010:38 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport11:51 AMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/4/2025 10:38:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 7/4/2025 11:51:00 AM. 50 Economy ticket for $213 per person are available. Travel duration is 1h 13m
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Volaris15h 19m09:32 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport12:51 AMTijuana AirportTijuana Airport0EconomyA Flight from Volaris goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/4/2025 9:32:00 AM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 7/5/2025 12:51:00 AM. 50 Economy ticket for $408 per person are available. Travel duration is 15h 19m
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FlixBus13h 30m08:00 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport9:30 PMSan DiegoSeaport Village0EconomyA Bus from FlixBus goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/4/2025 8:00:00 AM to Seaport Village, San Diego (USA) arriving at 7/4/2025 9:30:00 PM. 50 Economy ticket for $70 per person are available. Travel duration is 13h 30m
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FlixBus10h 10m08:00 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport6:10 PMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/4/2025 8:00:00 AM to Old Town Transit Center, San Diego (USA) arriving at 7/4/2025 6:10:00 PM. 50 Economy ticket for $70 per person are available. Travel duration is 10h 10m
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Desert bus Lines7h 10m01:00 PMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport8:10 PMSan DiegoOld Town Transit Center0Premium EconomyA Bus from Desert bus Lines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/4/2025 1:00:00 PM to Old Town Transit Center, San Diego (USA) arriving at 7/4/2025 8:10:00 PM. 50 Premium Economy ticket for $135 per person are available. Travel duration is 7h 10m
Cheapest Flights Friday
Cheapest Buses Friday
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Frontier Airlines1h 12m03:46 PMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport4:58 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/5/2025 3:46:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 7/5/2025 4:58:00 PM. 50 Economy ticket for $48 per person are available. Travel duration is 1h 12m
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American Airlines1h 17m07:39 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport8:56 AMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/5/2025 7:39:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 7/5/2025 8:56:00 AM. 50 Economy ticket for $103 per person are available. Travel duration is 1h 17m
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American Airlines1h 14m02:11 PMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport3:25 PMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/5/2025 2:11:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 7/5/2025 3:25:00 PM. 50 Economy ticket for $103 per person are available. Travel duration is 1h 14m
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American Airlines1h 10m06:08 PMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport7:18 PMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/5/2025 6:08:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 7/5/2025 7:18:00 PM. 50 Economy ticket for $103 per person are available. Travel duration is 1h 10m
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FlixBus13h 30m08:00 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport9:30 PMSan DiegoSeaport Village0EconomyA Bus from FlixBus goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/5/2025 8:00:00 AM to Seaport Village, San Diego (USA) arriving at 7/5/2025 9:30:00 PM. 50 Economy ticket for $100 per person are available. Travel duration is 13h 30m
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FlixBus10h 10m08:00 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport6:10 PMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/5/2025 8:00:00 AM to Old Town Transit Center, San Diego (USA) arriving at 7/5/2025 6:10:00 PM. 50 Economy ticket for $101 per person are available. Travel duration is 10h 10m
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Greyhound US19h 30m08:10 PMMesa, AZGreyhound3:40 PMSan DiegoSDSU Transit Center0EconomyA Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 7/5/2025 8:10:00 PM to SDSU Transit Center, San Diego (USA) arriving at 7/6/2025 3:40:00 PM. 50 Economy ticket for $122 per person are available. Travel duration is 19h 30m
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Greyhound US12h 35m08:10 PMMesa, AZGreyhound8:45 AMSan DiegoLa Jolla Village0EconomyA Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 7/5/2025 8:10:00 PM to La Jolla Village, San Diego (USA) arriving at 7/6/2025 8:45:00 AM. 50 Economy ticket for $123 per person are available. Travel duration is 12h 35m
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Desert bus Lines7h 10m01:00 PMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport8:10 PMSan DiegoOld Town Transit Center0Premium EconomyA Bus from Desert bus Lines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/5/2025 1:00:00 PM to Old Town Transit Center, San Diego (USA) arriving at 7/5/2025 8:10:00 PM. 50 Premium Economy ticket for $135 per person are available. Travel duration is 7h 10m
Cheapest Flights Saturday
Cheapest Buses Saturday
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Frontier Airlines1h 16m06:30 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport7:46 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/6/2025 6:30:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 7/6/2025 7:46:00 AM. 50 Economy ticket for $64 per person are available. Travel duration is 1h 16m
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Frontier Airlines1h 12m03:46 PMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport4:58 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/6/2025 3:46:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 7/6/2025 4:58:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 1h 12m
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American Airlines1h 17m07:39 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport8:56 AMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/6/2025 7:39:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 7/6/2025 8:56:00 AM. 50 Economy ticket for $170 per person are available. Travel duration is 1h 17m
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American Airlines1h 14m02:11 PMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport3:25 PMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/6/2025 2:11:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 7/6/2025 3:25:00 PM. 50 Economy ticket for $170 per person are available. Travel duration is 1h 14m
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American Airlines1h 10m06:08 PMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport7:18 PMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/6/2025 6:08:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 7/6/2025 7:18:00 PM. 50 Economy ticket for $170 per person are available. Travel duration is 1h 10m
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FlixBus13h 30m08:00 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport9:30 PMSan DiegoSeaport Village0EconomyA Bus from FlixBus goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/6/2025 8:00:00 AM to Seaport Village, San Diego (USA) arriving at 7/6/2025 9:30:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 13h 30m
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FlixBus10h 10m08:00 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport6:10 PMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/6/2025 8:00:00 AM to Old Town Transit Center, San Diego (USA) arriving at 7/6/2025 6:10:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 10h 10m
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Greyhound US13h 5m08:10 PMMesa, AZGreyhound9:15 AMSan DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 7/6/2025 8:10:00 PM to Old Town Transit Center, San Diego (USA) arriving at 7/7/2025 9:15:00 AM. 50 Economy ticket for $89 per person are available. Travel duration is 13h 5m
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Greyhound US14h 30m08:10 PMMesa, AZGreyhound10:40 AMSan DiegoSeaport Village0EconomyA Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 7/6/2025 8:10:00 PM to Seaport Village, San Diego (USA) arriving at 7/7/2025 10:40:00 AM. 50 Economy ticket for $90 per person are available. Travel duration is 14h 30m
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Desert bus Lines7h 10m01:00 PMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport8:10 PMSan DiegoOld Town Transit Center0Premium EconomyA Bus from Desert bus Lines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/6/2025 1:00:00 PM to Old Town Transit Center, San Diego (USA) arriving at 7/6/2025 8:10:00 PM. 50 Premium Economy ticket for $142 per person are available. Travel duration is 7h 10m
Cheapest Flights Sunday
Cheapest Buses Sunday
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Frontier Airlines1h 16m06:30 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport7:46 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/7/2025 6:30:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 7/7/2025 7:46:00 AM. 50 Economy ticket for $59 per person are available. Travel duration is 1h 16m
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Frontier Airlines1h 12m03:46 PMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport4:58 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/7/2025 3:46:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 7/7/2025 4:58:00 PM. 50 Economy ticket for $59 per person are available. Travel duration is 1h 12m
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American Airlines1h 17m07:39 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport8:56 AMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/7/2025 7:39:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 7/7/2025 8:56:00 AM. 50 Economy ticket for $170 per person are available. Travel duration is 1h 17m
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American Airlines1h 12m010:36 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport11:48 AMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/7/2025 10:36:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 7/7/2025 11:48:00 AM. 50 Economy ticket for $170 per person are available. Travel duration is 1h 12m
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JetBlue Airways1h 15m07:00 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport8:15 AMSan Diego AirportSan Diego Airport0EconomyA Flight from JetBlue Airways goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/7/2025 7:00:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 7/7/2025 8:15:00 AM. 50 Economy ticket for $302 per person are available. Travel duration is 1h 15m
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Aeroméxico10h 15m01:10 PMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport11:25 PMTijuana AirportTijuana Airport0EconomyA Flight from Aeroméxico goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/7/2025 1:10:00 PM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 7/7/2025 11:25:00 PM. 50 Economy ticket for $338 per person are available. Travel duration is 10h 15m
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FlixBus10h 10m08:00 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport6:10 PMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/7/2025 8:00:00 AM to Old Town Transit Center, San Diego (USA) arriving at 7/7/2025 6:10:00 PM. 50 Economy ticket for $66 per person are available. Travel duration is 10h 10m
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FlixBus13h 30m08:00 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport9:30 PMSan DiegoSeaport Village0EconomyA Bus from FlixBus goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/7/2025 8:00:00 AM to Seaport Village, San Diego (USA) arriving at 7/7/2025 9:30:00 PM. 50 Economy ticket for $67 per person are available. Travel duration is 13h 30m
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Greyhound US13h 20m08:10 PMMesa, AZGreyhound9:30 AMSan DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 7/7/2025 8:10:00 PM to Old Town Transit Center, San Diego (USA) arriving at 7/8/2025 9:30:00 AM. 50 Economy ticket for $80 per person are available. Travel duration is 13h 20m
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Greyhound US13h 5m08:10 PMMesa, AZGreyhound9:15 AMSan DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 7/7/2025 8:10:00 PM to Old Town Transit Center, San Diego (USA) arriving at 7/8/2025 9:15:00 AM. 50 Economy ticket for $81 per person are available. Travel duration is 13h 5m
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Desert bus Lines7h 10m01:00 PMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport8:10 PMSan DiegoOld Town Transit Center0Premium EconomyA Bus from Desert bus Lines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/7/2025 1:00:00 PM to Old Town Transit Center, San Diego (USA) arriving at 7/7/2025 8:10:00 PM. 50 Premium Economy ticket for $135 per person are available. Travel duration is 7h 10m
Cheapest Flights Monday
Cheapest Buses Monday
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FlixBus13h 30m08:00 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport9:30 PMSan DiegoSeaport Village0EconomyA Bus from FlixBus goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/8/2025 8:00:00 AM to Seaport Village, San Diego (USA) arriving at 7/8/2025 9:30:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 13h 30m
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FlixBus10h 10m08:00 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport6:10 PMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/8/2025 8:00:00 AM to Old Town Transit Center, San Diego (USA) arriving at 7/8/2025 6:10:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 10h 10m
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Greyhound US12h 35m08:10 PMMesa, AZGreyhound8:45 AMSan DiegoLa Jolla Village0EconomyA Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 7/8/2025 8:10:00 PM to La Jolla Village, San Diego (USA) arriving at 7/9/2025 8:45:00 AM. 50 Economy ticket for $83 per person are available. Travel duration is 12h 35m
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Greyhound US13h 5m08:10 PMMesa, AZGreyhound9:15 AMSan DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 7/8/2025 8:10:00 PM to Old Town Transit Center, San Diego (USA) arriving at 7/9/2025 9:15:00 AM. 50 Economy ticket for $84 per person are available. Travel duration is 13h 5m
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Desert bus Lines7h 10m01:00 PMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport8:10 PMSan DiegoOld Town Transit Center0Premium EconomyA Bus from Desert bus Lines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/8/2025 1:00:00 PM to Old Town Transit Center, San Diego (USA) arriving at 7/8/2025 8:10:00 PM. 50 Premium Economy ticket for $135 per person are available. Travel duration is 7h 10m
Cheapest Buses Tuesday
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Greyhound US13h 55m08:10 PMMesa, AZGreyhound10:05 AMSan DiegoSan Ysidro Transit Center0EconomyA Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 7/9/2025 8:10:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 7/10/2025 10:05:00 AM. 50 Economy ticket for $72 per person are available. Travel duration is 13h 55m
Cheapest Buses Wednesday
What are the fastest trips from Mesa, AZ to San Diego?
You can get to San Diego from Mesa, AZ in just 1h 8m with a Flight from American Airlines. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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American Airlines1h 9m06:20 PMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport7:29 PMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/3/2025 6:20:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 7/3/2025 7:29:00 PM. 50 Economy ticket for $264 per person are available. Travel duration is 1h 9m
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American Airlines1h 13m08:35 PMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport9:48 PMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/3/2025 8:35:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 7/3/2025 9:48:00 PM. 50 Economy ticket for $264 per person are available. Travel duration is 1h 13m
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Frontier Airlines1h 18m01:00 PMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport2:18 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/3/2025 1:00:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 7/3/2025 2:18:00 PM. 50 Economy ticket for $197 per person are available. Travel duration is 1h 18m
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American Airlines1h 20m07:30 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport8:50 AMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/3/2025 7:30:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 7/3/2025 8:50:00 AM. 50 Economy ticket for $264 per person are available. Travel duration is 1h 20m
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Desert bus Lines7h 10m01:00 PMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport8:10 PMSan DiegoOld Town Transit Center0Premium EconomyA Bus from Desert bus Lines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/3/2025 1:00:00 PM to Old Town Transit Center, San Diego (USA) arriving at 7/3/2025 8:10:00 PM. 50 Premium Economy ticket for $135 per person are available. Travel duration is 7h 10m
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FlixBus10h 10m08:00 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport6:10 PMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/3/2025 8:00:00 AM to Old Town Transit Center, San Diego (USA) arriving at 7/3/2025 6:10:00 PM. 50 Economy ticket for $145 per person are available. Travel duration is 10h 10m
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Greyhound US13h 20m08:10 PMMesa, AZGreyhound9:30 AMSan DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 7/3/2025 8:10:00 PM to Old Town Transit Center, San Diego (USA) arriving at 7/4/2025 9:30:00 AM. 50 Economy ticket for $74 per person are available. Travel duration is 13h 20m
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FlixBus13h 30m08:00 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport9:30 PMSan DiegoSeaport Village0EconomyA Bus from FlixBus goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/3/2025 8:00:00 AM to Seaport Village, San Diego (USA) arriving at 7/3/2025 9:30:00 PM. 50 Economy ticket for $145 per person are available. Travel duration is 13h 30m
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Greyhound US14h 30m08:10 PMMesa, AZGreyhound10:40 AMSan DiegoSeaport Village0EconomyA Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 7/3/2025 8:10:00 PM to Seaport Village, San Diego (USA) arriving at 7/4/2025 10:40:00 AM. 50 Economy ticket for $74 per person are available. Travel duration is 14h 30m
Fastest Flights Thursday
Fastest Buses Thursday
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American Airlines1h 8m02:11 PMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport3:19 PMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/4/2025 2:11:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 7/4/2025 3:19:00 PM. 50 Economy ticket for $171 per person are available. Travel duration is 1h 8m
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Frontier Airlines1h 12m03:46 PMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport4:58 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/4/2025 3:46:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 7/4/2025 4:58:00 PM. 50 Economy ticket for $60 per person are available. Travel duration is 1h 12m
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American Airlines1h 13m010:38 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport11:51 AMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/4/2025 10:38:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 7/4/2025 11:51:00 AM. 50 Economy ticket for $213 per person are available. Travel duration is 1h 13m
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Frontier Airlines1h 14m06:30 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport7:44 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/4/2025 6:30:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 7/4/2025 7:44:00 AM. 50 Economy ticket for $116 per person are available. Travel duration is 1h 14m
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American Airlines1h 20m07:30 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport8:50 AMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/4/2025 7:30:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 7/4/2025 8:50:00 AM. 50 Economy ticket for $182 per person are available. Travel duration is 1h 20m
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Volaris8h 32m09:32 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport6:04 PMTijuana AirportTijuana Airport0EconomyA Flight from Volaris goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/4/2025 9:32:00 AM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 7/4/2025 6:04:00 PM. 50 Economy ticket for $442 per person are available. Travel duration is 8h 32m
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Desert bus Lines7h 10m01:00 PMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport8:10 PMSan DiegoOld Town Transit Center0Premium EconomyA Bus from Desert bus Lines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/4/2025 1:00:00 PM to Old Town Transit Center, San Diego (USA) arriving at 7/4/2025 8:10:00 PM. 50 Premium Economy ticket for $135 per person are available. Travel duration is 7h 10m
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FlixBus10h 10m08:00 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport6:10 PMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/4/2025 8:00:00 AM to Old Town Transit Center, San Diego (USA) arriving at 7/4/2025 6:10:00 PM. 50 Economy ticket for $70 per person are available. Travel duration is 10h 10m
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FlixBus13h 30m08:00 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport9:30 PMSan DiegoSeaport Village0EconomyA Bus from FlixBus goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/4/2025 8:00:00 AM to Seaport Village, San Diego (USA) arriving at 7/4/2025 9:30:00 PM. 50 Economy ticket for $70 per person are available. Travel duration is 13h 30m
Fastest Flights Friday
Fastest Buses Friday
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American Airlines1h 10m06:08 PMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport7:18 PMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/5/2025 6:08:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 7/5/2025 7:18:00 PM. 50 Economy ticket for $103 per person are available. Travel duration is 1h 10m
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Frontier Airlines1h 12m03:46 PMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport4:58 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/5/2025 3:46:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 7/5/2025 4:58:00 PM. 50 Economy ticket for $48 per person are available. Travel duration is 1h 12m
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American Airlines1h 14m02:11 PMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport3:25 PMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/5/2025 2:11:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 7/5/2025 3:25:00 PM. 50 Economy ticket for $103 per person are available. Travel duration is 1h 14m
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American Airlines1h 17m07:39 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport8:56 AMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/5/2025 7:39:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 7/5/2025 8:56:00 AM. 50 Economy ticket for $103 per person are available. Travel duration is 1h 17m
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Desert bus Lines7h 10m01:00 PMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport8:10 PMSan DiegoOld Town Transit Center0Premium EconomyA Bus from Desert bus Lines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/5/2025 1:00:00 PM to Old Town Transit Center, San Diego (USA) arriving at 7/5/2025 8:10:00 PM. 50 Premium Economy ticket for $135 per person are available. Travel duration is 7h 10m
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FlixBus10h 10m08:00 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport6:10 PMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/5/2025 8:00:00 AM to Old Town Transit Center, San Diego (USA) arriving at 7/5/2025 6:10:00 PM. 50 Economy ticket for $101 per person are available. Travel duration is 10h 10m
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Greyhound US12h 35m08:10 PMMesa, AZGreyhound8:45 AMSan DiegoLa Jolla Village0EconomyA Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 7/5/2025 8:10:00 PM to La Jolla Village, San Diego (USA) arriving at 7/6/2025 8:45:00 AM. 50 Economy ticket for $123 per person are available. Travel duration is 12h 35m
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FlixBus13h 30m08:00 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport9:30 PMSan DiegoSeaport Village0EconomyA Bus from FlixBus goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/5/2025 8:00:00 AM to Seaport Village, San Diego (USA) arriving at 7/5/2025 9:30:00 PM. 50 Economy ticket for $100 per person are available. Travel duration is 13h 30m
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Greyhound US19h 30m08:10 PMMesa, AZGreyhound3:40 PMSan DiegoSDSU Transit Center0EconomyA Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 7/5/2025 8:10:00 PM to SDSU Transit Center, San Diego (USA) arriving at 7/6/2025 3:40:00 PM. 50 Economy ticket for $122 per person are available. Travel duration is 19h 30m
Fastest Flights Saturday
Fastest Buses Saturday
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American Airlines1h 10m06:08 PMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport7:18 PMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/6/2025 6:08:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 7/6/2025 7:18:00 PM. 50 Economy ticket for $170 per person are available. Travel duration is 1h 10m
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Frontier Airlines1h 12m03:46 PMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport4:58 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/6/2025 3:46:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 7/6/2025 4:58:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 1h 12m
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American Airlines1h 14m02:11 PMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport3:25 PMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/6/2025 2:11:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 7/6/2025 3:25:00 PM. 50 Economy ticket for $170 per person are available. Travel duration is 1h 14m
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Frontier Airlines1h 16m06:30 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport7:46 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/6/2025 6:30:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 7/6/2025 7:46:00 AM. 50 Economy ticket for $64 per person are available. Travel duration is 1h 16m
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American Airlines1h 17m07:39 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport8:56 AMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/6/2025 7:39:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 7/6/2025 8:56:00 AM. 50 Economy ticket for $170 per person are available. Travel duration is 1h 17m
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Desert bus Lines7h 10m01:00 PMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport8:10 PMSan DiegoOld Town Transit Center0Premium EconomyA Bus from Desert bus Lines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/6/2025 1:00:00 PM to Old Town Transit Center, San Diego (USA) arriving at 7/6/2025 8:10:00 PM. 50 Premium Economy ticket for $142 per person are available. Travel duration is 7h 10m
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FlixBus10h 10m08:00 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport6:10 PMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/6/2025 8:00:00 AM to Old Town Transit Center, San Diego (USA) arriving at 7/6/2025 6:10:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 10h 10m
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Greyhound US13h 5m08:10 PMMesa, AZGreyhound9:15 AMSan DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 7/6/2025 8:10:00 PM to Old Town Transit Center, San Diego (USA) arriving at 7/7/2025 9:15:00 AM. 50 Economy ticket for $89 per person are available. Travel duration is 13h 5m
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FlixBus13h 30m08:00 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport9:30 PMSan DiegoSeaport Village0EconomyA Bus from FlixBus goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/6/2025 8:00:00 AM to Seaport Village, San Diego (USA) arriving at 7/6/2025 9:30:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 13h 30m
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Greyhound US14h 30m08:10 PMMesa, AZGreyhound10:40 AMSan DiegoSeaport Village0EconomyA Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 7/6/2025 8:10:00 PM to Seaport Village, San Diego (USA) arriving at 7/7/2025 10:40:00 AM. 50 Economy ticket for $90 per person are available. Travel duration is 14h 30m
Fastest Flights Sunday
Fastest Buses Sunday
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Frontier Airlines1h 12m03:46 PMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport4:58 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/7/2025 3:46:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 7/7/2025 4:58:00 PM. 50 Economy ticket for $59 per person are available. Travel duration is 1h 12m
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American Airlines1h 12m010:36 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport11:48 AMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/7/2025 10:36:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 7/7/2025 11:48:00 AM. 50 Economy ticket for $170 per person are available. Travel duration is 1h 12m
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JetBlue Airways1h 15m07:00 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport8:15 AMSan Diego AirportSan Diego Airport0EconomyA Flight from JetBlue Airways goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/7/2025 7:00:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 7/7/2025 8:15:00 AM. 50 Economy ticket for $302 per person are available. Travel duration is 1h 15m
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Frontier Airlines1h 16m06:30 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport7:46 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/7/2025 6:30:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 7/7/2025 7:46:00 AM. 50 Economy ticket for $59 per person are available. Travel duration is 1h 16m
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American Airlines1h 17m07:39 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport8:56 AMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/7/2025 7:39:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 7/7/2025 8:56:00 AM. 50 Economy ticket for $170 per person are available. Travel duration is 1h 17m
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Volaris9h 33m09:32 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport7:05 PMTijuana AirportTijuana Airport0EconomyA Flight from Volaris goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/7/2025 9:32:00 AM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 7/7/2025 7:05:00 PM. 50 Economy ticket for $357 per person are available. Travel duration is 9h 33m
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Desert bus Lines7h 10m01:00 PMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport8:10 PMSan DiegoOld Town Transit Center0Premium EconomyA Bus from Desert bus Lines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/7/2025 1:00:00 PM to Old Town Transit Center, San Diego (USA) arriving at 7/7/2025 8:10:00 PM. 50 Premium Economy ticket for $135 per person are available. Travel duration is 7h 10m
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FlixBus10h 10m08:00 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport6:10 PMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/7/2025 8:00:00 AM to Old Town Transit Center, San Diego (USA) arriving at 7/7/2025 6:10:00 PM. 50 Economy ticket for $66 per person are available. Travel duration is 10h 10m
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Greyhound US13h 5m08:10 PMMesa, AZGreyhound9:15 AMSan DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 7/7/2025 8:10:00 PM to Old Town Transit Center, San Diego (USA) arriving at 7/8/2025 9:15:00 AM. 50 Economy ticket for $81 per person are available. Travel duration is 13h 5m
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Greyhound US13h 20m08:10 PMMesa, AZGreyhound9:30 AMSan DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 7/7/2025 8:10:00 PM to Old Town Transit Center, San Diego (USA) arriving at 7/8/2025 9:30:00 AM. 50 Economy ticket for $80 per person are available. Travel duration is 13h 20m
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FlixBus13h 30m08:00 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport9:30 PMSan DiegoSeaport Village0EconomyA Bus from FlixBus goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/7/2025 8:00:00 AM to Seaport Village, San Diego (USA) arriving at 7/7/2025 9:30:00 PM. 50 Economy ticket for $67 per person are available. Travel duration is 13h 30m
Fastest Flights Monday
Fastest Buses Monday
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Desert bus Lines7h 10m01:00 PMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport8:10 PMSan DiegoOld Town Transit Center0Premium EconomyA Bus from Desert bus Lines goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/8/2025 1:00:00 PM to Old Town Transit Center, San Diego (USA) arriving at 7/8/2025 8:10:00 PM. 50 Premium Economy ticket for $135 per person are available. Travel duration is 7h 10m
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FlixBus10h 10m08:00 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport6:10 PMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/8/2025 8:00:00 AM to Old Town Transit Center, San Diego (USA) arriving at 7/8/2025 6:10:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 10h 10m
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Greyhound US12h 35m08:10 PMMesa, AZGreyhound8:45 AMSan DiegoLa Jolla Village0EconomyA Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 7/8/2025 8:10:00 PM to La Jolla Village, San Diego (USA) arriving at 7/9/2025 8:45:00 AM. 50 Economy ticket for $83 per person are available. Travel duration is 12h 35m
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Greyhound US13h 5m08:10 PMMesa, AZGreyhound9:15 AMSan DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 7/8/2025 8:10:00 PM to Old Town Transit Center, San Diego (USA) arriving at 7/9/2025 9:15:00 AM. 50 Economy ticket for $84 per person are available. Travel duration is 13h 5m
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FlixBus13h 30m08:00 AMPhoenix Sky Harbor AirportPhoenix Sky Harbor Airport9:30 PMSan DiegoSeaport Village0EconomyA Bus from FlixBus goes from Phoenix Sky Harbor Airport, Phoenix Sky Harbor Airport (USA) at 7/8/2025 8:00:00 AM to Seaport Village, San Diego (USA) arriving at 7/8/2025 9:30:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 13h 30m
Fastest Buses Tuesday
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Greyhound US13h 55m08:10 PMMesa, AZGreyhound10:05 AMSan DiegoSan Ysidro Transit Center0EconomyA Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 7/9/2025 8:10:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 7/10/2025 10:05:00 AM. 50 Economy ticket for $72 per person are available. Travel duration is 13h 55m
Fastest Buses Wednesday
Here you will find all operators and timetables for a
Bus from Mesa, AZ to San Diego
What are the most popular stations in Mesa, AZ and San Diego?
In Mesa, AZ, you will usually depart from Greyhound or Fry’s Fuel Center, while in San Diego you will be arriving at Santa Fe Depot, San Ysidro Transit Center or Old Town Transit Center, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to San Diego from Mesa, AZ? With 8 connections between 1 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Mesa, AZ and San Diego, you can pay as low as $48 with a Flight from Frontier Airlines.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from American Airlines: you will get to San Diego in just 1h 8m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Mesa, AZ and San Diego are American Airlines, FlixBus and Greyhound US, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Mesa, AZ and San Diego is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Tempe, AZ or to San Diego Airport, and look at flights from Phoenix Sky Harbor Airport, and landing at Tijuana Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Mesa, AZ to San Diego?
The most popular companies between Mesa, AZ and San Diego, are American Airlines, FlixBus and Greyhound US. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus, Greyhound US and Desert bus Lines
Airlines: American Airlines, Frontier Airlines, Volaris and 2 more.
All you need to know when you travel from Mesa, AZ to San Diego
Check all information on comfort and services on all modes of transports from Mesa, AZ to San Diego. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Mesa, AZ to San Diego
How can I reach San Diego from Mesa, AZ?
Every day, there are on average 8 connections between Bus and Flight, with which you can get to San Diego from Mesa, AZ.
How far is San Diego from Mesa, AZ?
The distance between Mesa, AZ and San Diego is 311.8 miles.
What is the most ecofriendly mode of transport between Mesa, AZ and San Diego?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 14 kgs of CO2, a train 18 kgs, a car 85 kgs, and a flight 123 kgs.
What is the cheapest mode of transport from Mesa, AZ to San Diego?
You can get to San Diego with just $48 by taking a Flight from Frontier Airlines.
What is the fastest way to get from Mesa, AZ to San Diego?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to San Diego in just 1h 8m with a Flight from American Airlines.
More routes to Mesa, AZ and to San Diego
Looking for more options? Here you can see the most popular routes to Mesa, AZ and to San Diego. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Mesa, AZ
- San Diego to Mesa, AZ