What is the best way to travel from Pittsburgh to St. Louis, MO?
Looking for a trip? Compare all the available Buses and Flights for the journey to St. Louis, MO from Pittsburgh. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
What is the cheapest way to reach St. Louis, MO from Pittsburgh?
You can get to St. Louis, MO with just $75 by taking a Bus from Greyhound US, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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Greyhound US11h 55m06:30 PMPittsburghGrant Street Transportation Center6:25 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 6/29/2025 6:30:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/30/2025 6:25:00 AM. 50 Economy ticket for $79 per person are available. Travel duration is 11h 55m
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Greyhound US12h 45m010:50 AMPittsburghGrant Street Transportation Center11:35 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 6/29/2025 10:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/29/2025 11:35:00 PM. 50 Economy ticket for $84 per person are available. Travel duration is 12h 45m
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Greyhound US13h 45m01:35 AMPittsburghGrant Street Transportation Center3:20 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 6/29/2025 1:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/29/2025 3:20:00 PM. 50 Economy ticket for $109 per person are available. Travel duration is 13h 45m
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Frontier Airlines15h 3m09:50 AMPittsburgh AirportPittsburgh Airport11:53 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 6/29/2025 9:50:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/29/2025 11:53:00 PM. 50 Economy ticket for $182 per person are available. Travel duration is 15h 3m
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Spirit Airlines28h 33m07:00 AMPittsburgh AirportPittsburgh Airport10:33 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 6/29/2025 7:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/30/2025 10:33:00 AM. 50 Economy ticket for $218 per person are available. Travel duration is 28h 33m
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Skyscanner4h 44m06:15 AMPittsburgh AirportPittsburgh Airport9:59 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 6/29/2025 6:15:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/29/2025 9:59:00 AM. 50 Economy ticket for $371 per person are available. Travel duration is 4h 44m
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United Airlines4h 32m011:05 AMPittsburgh AirportPittsburgh Airport2:37 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 6/29/2025 11:05:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/29/2025 2:37:00 PM. 50 Economy ticket for $371 per person are available. Travel duration is 4h 32m
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Alaska Airlines16h 56m08:03 AMPittsburgh AirportPittsburgh Airport11:59 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Alaska Airlines goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 6/29/2025 8:03:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/29/2025 11:59:00 PM. 50 Economy ticket for $582 per person are available. Travel duration is 16h 56m
Cheapest Buses Sunday
Cheapest Flights Sunday
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Greyhound US11h 55m06:30 PMPittsburghGrant Street Transportation Center6:25 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 6/30/2025 6:30:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/1/2025 6:25:00 AM. 50 Economy ticket for $79 per person are available. Travel duration is 11h 55m
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Greyhound US12h 45m010:50 AMPittsburghGrant Street Transportation Center11:35 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 6/30/2025 10:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/30/2025 11:35:00 PM. 50 Economy ticket for $84 per person are available. Travel duration is 12h 45m
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Greyhound US13h 45m01:35 AMPittsburghGrant Street Transportation Center3:20 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 6/30/2025 1:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/30/2025 3:20:00 PM. 50 Economy ticket for $91 per person are available. Travel duration is 13h 45m
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FlixBus20h 15m07:30 PMPittsburghGrant Street Transportation Center3:45 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Grant Street Transportation Center, Pittsburgh (USA) at 6/30/2025 7:30:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/1/2025 3:45:00 PM. 50 Economy ticket for $139 per person are available. Travel duration is 20h 15m
Cheapest Buses Monday
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Greyhound US13h 45m01:35 AMPittsburghGrant Street Transportation Center3:20 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 7/3/2025 1:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/3/2025 3:20:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 13h 45m
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Greyhound US12h 45m010:50 AMPittsburghGrant Street Transportation Center11:35 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 7/3/2025 10:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/3/2025 11:35:00 PM. 50 Economy ticket for $84 per person are available. Travel duration is 12h 45m
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FlixBus20h 15m07:30 PMPittsburghGrant Street Transportation Center3:45 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Grant Street Transportation Center, Pittsburgh (USA) at 7/3/2025 7:30:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/4/2025 3:45:00 PM. 50 Economy ticket for $140 per person are available. Travel duration is 20h 15m
Cheapest Buses Thursday
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Greyhound US13h 45m01:35 AMPittsburghGrant Street Transportation Center3:20 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 7/4/2025 1:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/4/2025 3:20:00 PM. 50 Economy ticket for $79 per person are available. Travel duration is 13h 45m
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Greyhound US11h 55m06:30 PMPittsburghGrant Street Transportation Center6:25 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 7/4/2025 6:30:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/5/2025 6:25:00 AM. 50 Economy ticket for $84 per person are available. Travel duration is 11h 55m
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Greyhound US12h 45m010:50 AMPittsburghGrant Street Transportation Center11:35 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 7/4/2025 10:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/4/2025 11:35:00 PM. 50 Economy ticket for $89 per person are available. Travel duration is 12h 45m
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Frontier Airlines6h 3m06:50 PMPittsburgh AirportPittsburgh Airport11:53 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 7/4/2025 6:50:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/4/2025 11:53:00 PM. 50 Economy ticket for $114 per person are available. Travel duration is 6h 3m
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Spirit Airlines7h 50m07:00 AMPittsburgh AirportPittsburgh Airport1:50 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 7/4/2025 7:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/4/2025 1:50:00 PM. 50 Economy ticket for $245 per person are available. Travel duration is 7h 50m
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Skyscanner4h 42m08:45 AMPittsburgh AirportPittsburgh Airport12:27 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 7/4/2025 8:45:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/4/2025 12:27:00 PM. 50 Economy ticket for $358 per person are available. Travel duration is 4h 42m
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United Airlines4h 30m07:10 AMPittsburgh AirportPittsburgh Airport10:40 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 7/4/2025 7:10:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/4/2025 10:40:00 AM. 50 Economy ticket for $358 per person are available. Travel duration is 4h 30m
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Alaska Airlines19h 44m07:42 PMPittsburgh AirportPittsburgh Airport2:26 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Alaska Airlines goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 7/4/2025 7:42:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/5/2025 2:26:00 PM. 50 Economy ticket for $371 per person are available. Travel duration is 19h 44m
Cheapest Buses Friday
Cheapest Flights Friday
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Greyhound US13h 45m01:35 AMPittsburghGrant Street Transportation Center3:20 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 7/5/2025 1:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/5/2025 3:20:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 13h 45m
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Greyhound US11h 55m06:30 PMPittsburghGrant Street Transportation Center6:25 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 7/5/2025 6:30:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/6/2025 6:25:00 AM. 50 Economy ticket for $81 per person are available. Travel duration is 11h 55m
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Greyhound US12h 45m010:50 AMPittsburghGrant Street Transportation Center11:35 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 7/5/2025 10:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/5/2025 11:35:00 PM. 50 Economy ticket for $100 per person are available. Travel duration is 12h 45m
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FlixBus20h 15m07:30 PMPittsburghGrant Street Transportation Center3:45 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Grant Street Transportation Center, Pittsburgh (USA) at 7/5/2025 7:30:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/6/2025 3:45:00 PM. 50 Economy ticket for $140 per person are available. Travel duration is 20h 15m
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Skyscanner4h 44m06:15 AMPittsburgh AirportPittsburgh Airport9:59 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 7/5/2025 6:15:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/5/2025 9:59:00 AM. 50 Economy ticket for $364 per person are available. Travel duration is 4h 44m
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Skyscanner5h 1m08:45 AMPittsburgh AirportPittsburgh Airport12:46 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 7/5/2025 8:45:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/5/2025 12:46:00 PM. 50 Economy ticket for $364 per person are available. Travel duration is 5h 1m
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United Airlines4h 30m07:10 AMPittsburgh AirportPittsburgh Airport10:40 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 7/5/2025 7:10:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/5/2025 10:40:00 AM. 50 Economy ticket for $364 per person are available. Travel duration is 4h 30m
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United Airlines4h 32m011:05 AMPittsburgh AirportPittsburgh Airport2:37 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 7/5/2025 11:05:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/5/2025 2:37:00 PM. 50 Economy ticket for $364 per person are available. Travel duration is 4h 32m
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Alaska Airlines29h 17m07:42 PMPittsburgh AirportPittsburgh Airport11:59 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Alaska Airlines goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 7/5/2025 7:42:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/6/2025 11:59:00 PM. 50 Economy ticket for $368 per person are available. Travel duration is 29h 17m
Cheapest Buses Saturday
Cheapest Flights Saturday
What are the fastest trips from Pittsburgh to St. Louis, MO?
You can get to St. Louis, MO from Pittsburgh in just 4h 30m with a Flight from United Airlines. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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United Airlines4h 32m011:05 AMPittsburgh AirportPittsburgh Airport2:37 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 6/29/2025 11:05:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/29/2025 2:37:00 PM. 50 Economy ticket for $371 per person are available. Travel duration is 4h 32m
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Skyscanner4h 44m06:15 AMPittsburgh AirportPittsburgh Airport9:59 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 6/29/2025 6:15:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/29/2025 9:59:00 AM. 50 Economy ticket for $371 per person are available. Travel duration is 4h 44m
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Frontier Airlines15h 3m09:50 AMPittsburgh AirportPittsburgh Airport11:53 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 6/29/2025 9:50:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/29/2025 11:53:00 PM. 50 Economy ticket for $182 per person are available. Travel duration is 15h 3m
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Alaska Airlines16h 56m08:03 AMPittsburgh AirportPittsburgh Airport11:59 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Alaska Airlines goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 6/29/2025 8:03:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/29/2025 11:59:00 PM. 50 Economy ticket for $582 per person are available. Travel duration is 16h 56m
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Spirit Airlines28h 33m07:00 AMPittsburgh AirportPittsburgh Airport10:33 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 6/29/2025 7:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/30/2025 10:33:00 AM. 50 Economy ticket for $218 per person are available. Travel duration is 28h 33m
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Greyhound US11h 55m06:30 PMPittsburghGrant Street Transportation Center6:25 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 6/29/2025 6:30:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/30/2025 6:25:00 AM. 50 Economy ticket for $79 per person are available. Travel duration is 11h 55m
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Greyhound US12h 45m010:50 AMPittsburghGrant Street Transportation Center11:35 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 6/29/2025 10:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/29/2025 11:35:00 PM. 50 Economy ticket for $84 per person are available. Travel duration is 12h 45m
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Greyhound US13h 45m01:35 AMPittsburghGrant Street Transportation Center3:20 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 6/29/2025 1:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/29/2025 3:20:00 PM. 50 Economy ticket for $109 per person are available. Travel duration is 13h 45m
Fastest Flights Sunday
Fastest Buses Sunday
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Greyhound US11h 55m06:30 PMPittsburghGrant Street Transportation Center6:25 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 6/30/2025 6:30:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/1/2025 6:25:00 AM. 50 Economy ticket for $79 per person are available. Travel duration is 11h 55m
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Greyhound US12h 45m010:50 AMPittsburghGrant Street Transportation Center11:35 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 6/30/2025 10:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/30/2025 11:35:00 PM. 50 Economy ticket for $84 per person are available. Travel duration is 12h 45m
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Greyhound US13h 45m01:35 AMPittsburghGrant Street Transportation Center3:20 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 6/30/2025 1:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/30/2025 3:20:00 PM. 50 Economy ticket for $91 per person are available. Travel duration is 13h 45m
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FlixBus20h 15m07:30 PMPittsburghGrant Street Transportation Center3:45 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Grant Street Transportation Center, Pittsburgh (USA) at 6/30/2025 7:30:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/1/2025 3:45:00 PM. 50 Economy ticket for $139 per person are available. Travel duration is 20h 15m
Fastest Buses Monday
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Greyhound US12h 45m010:50 AMPittsburghGrant Street Transportation Center11:35 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 7/3/2025 10:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/3/2025 11:35:00 PM. 50 Economy ticket for $84 per person are available. Travel duration is 12h 45m
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Greyhound US13h 45m01:35 AMPittsburghGrant Street Transportation Center3:20 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 7/3/2025 1:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/3/2025 3:20:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 13h 45m
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FlixBus20h 15m07:30 PMPittsburghGrant Street Transportation Center3:45 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Grant Street Transportation Center, Pittsburgh (USA) at 7/3/2025 7:30:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/4/2025 3:45:00 PM. 50 Economy ticket for $140 per person are available. Travel duration is 20h 15m
Fastest Buses Thursday
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United Airlines4h 30m07:10 AMPittsburgh AirportPittsburgh Airport10:40 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 7/4/2025 7:10:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/4/2025 10:40:00 AM. 50 Economy ticket for $358 per person are available. Travel duration is 4h 30m
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Skyscanner4h 42m08:45 AMPittsburgh AirportPittsburgh Airport12:27 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 7/4/2025 8:45:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/4/2025 12:27:00 PM. 50 Economy ticket for $358 per person are available. Travel duration is 4h 42m
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Frontier Airlines6h 3m06:50 PMPittsburgh AirportPittsburgh Airport11:53 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 7/4/2025 6:50:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/4/2025 11:53:00 PM. 50 Economy ticket for $114 per person are available. Travel duration is 6h 3m
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Spirit Airlines7h 50m07:00 AMPittsburgh AirportPittsburgh Airport1:50 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 7/4/2025 7:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/4/2025 1:50:00 PM. 50 Economy ticket for $245 per person are available. Travel duration is 7h 50m
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Alaska Airlines19h 44m07:42 PMPittsburgh AirportPittsburgh Airport2:26 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Alaska Airlines goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 7/4/2025 7:42:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/5/2025 2:26:00 PM. 50 Economy ticket for $371 per person are available. Travel duration is 19h 44m
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Greyhound US11h 55m06:30 PMPittsburghGrant Street Transportation Center6:25 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 7/4/2025 6:30:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/5/2025 6:25:00 AM. 50 Economy ticket for $84 per person are available. Travel duration is 11h 55m
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Greyhound US12h 45m010:50 AMPittsburghGrant Street Transportation Center11:35 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 7/4/2025 10:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/4/2025 11:35:00 PM. 50 Economy ticket for $89 per person are available. Travel duration is 12h 45m
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Greyhound US13h 45m01:35 AMPittsburghGrant Street Transportation Center3:20 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 7/4/2025 1:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/4/2025 3:20:00 PM. 50 Economy ticket for $79 per person are available. Travel duration is 13h 45m
Fastest Flights Friday
Fastest Buses Friday
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United Airlines4h 30m07:10 AMPittsburgh AirportPittsburgh Airport10:40 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 7/5/2025 7:10:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/5/2025 10:40:00 AM. 50 Economy ticket for $364 per person are available. Travel duration is 4h 30m
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United Airlines4h 32m011:05 AMPittsburgh AirportPittsburgh Airport2:37 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 7/5/2025 11:05:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/5/2025 2:37:00 PM. 50 Economy ticket for $364 per person are available. Travel duration is 4h 32m
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Skyscanner4h 44m06:15 AMPittsburgh AirportPittsburgh Airport9:59 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 7/5/2025 6:15:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/5/2025 9:59:00 AM. 50 Economy ticket for $364 per person are available. Travel duration is 4h 44m
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Skyscanner5h 1m08:45 AMPittsburgh AirportPittsburgh Airport12:46 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 7/5/2025 8:45:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/5/2025 12:46:00 PM. 50 Economy ticket for $364 per person are available. Travel duration is 5h 1m
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Alaska Airlines29h 17m07:42 PMPittsburgh AirportPittsburgh Airport11:59 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Alaska Airlines goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 7/5/2025 7:42:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/6/2025 11:59:00 PM. 50 Economy ticket for $368 per person are available. Travel duration is 29h 17m
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Greyhound US11h 55m06:30 PMPittsburghGrant Street Transportation Center6:25 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 7/5/2025 6:30:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/6/2025 6:25:00 AM. 50 Economy ticket for $81 per person are available. Travel duration is 11h 55m
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Greyhound US12h 45m010:50 AMPittsburghGrant Street Transportation Center11:35 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 7/5/2025 10:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/5/2025 11:35:00 PM. 50 Economy ticket for $100 per person are available. Travel duration is 12h 45m
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Greyhound US13h 45m01:35 AMPittsburghGrant Street Transportation Center3:20 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 7/5/2025 1:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/5/2025 3:20:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 13h 45m
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FlixBus20h 15m07:30 PMPittsburghGrant Street Transportation Center3:45 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Grant Street Transportation Center, Pittsburgh (USA) at 7/5/2025 7:30:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/6/2025 3:45:00 PM. 50 Economy ticket for $140 per person are available. Travel duration is 20h 15m
Fastest Flights Saturday
Fastest Buses Saturday
Here you will find all operators and timetables for a
Bus from Pittsburgh to St. Louis, MO
What are the most popular stations in Pittsburgh and St. Louis, MO?
In Pittsburgh, you will usually depart from David L. Lawrence Convention Center, Central Station or University of, while in St. Louis, MO you will be arriving at Gateway Station, Lindbergh @ Hackberry NB Bus Stop or Skinker Boulevard, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to St. Louis, MO from Pittsburgh? With 7 connections between 2 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Pittsburgh and St. Louis, MO, you can pay as low as $75 with a Bus from Greyhound US.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from United Airlines: you will get to St. Louis, MO in just 4h 30m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Pittsburgh and St. Louis, MO are Greyhound US, Skyscanner and United Airlines, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Pittsburgh and St. Louis, MO is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Green Tree, PA or to Sauget, IL, and look at flights from Pittsburgh Airport, and landing at St. Louis Lambert Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Pittsburgh to St. Louis, MO?
The most popular companies between Pittsburgh and St. Louis, MO, are Greyhound US, Skyscanner and United Airlines. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Greyhound US and FlixBus
Airlines: Skyscanner, United Airlines, Alaska Airlines and 2 more.
All you need to know when you travel from Pittsburgh to St. Louis, MO
Check all information on comfort and services on all modes of transports from Pittsburgh to St. Louis, MO. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Pittsburgh to St. Louis, MO
How can I reach St. Louis, MO from Pittsburgh?
Every day, there are on average 7 connections between Bus and Flight, with which you can get to St. Louis, MO from Pittsburgh.
How far is St. Louis, MO from Pittsburgh?
The distance between Pittsburgh and St. Louis, MO is 558.2 miles.
What is the most ecofriendly mode of transport between Pittsburgh and St. Louis, MO?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 24 kgs of CO2, a train 31 kgs, a car 153 kgs, and a flight 221 kgs.
What is the cheapest mode of transport from Pittsburgh to St. Louis, MO?
You can get to St. Louis, MO with just $75 by taking a Bus from Greyhound US.
What is the fastest way to get from Pittsburgh to St. Louis, MO?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to St. Louis, MO in just 4h 30m with a Flight from United Airlines.
More routes to Pittsburgh and to St. Louis, MO
Looking for more options? Here you can see the most popular routes to Pittsburgh and to St. Louis, MO. Simply click on a connection, and you’ll find all the details about the route!