What is the best way to travel from Pittsburgh to St. Louis, MO?
Looking for a trip? Compare all the available Buses and Flights for the journey to St. Louis, MO from Pittsburgh. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 1 available companies to find your perfect trip!
What is the cheapest way to reach St. Louis, MO from Pittsburgh?
You can get to St. Louis, MO with just $70 by taking a Bus from Greyhound US, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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Greyhound US14h 45m01:35 AMPittsburghGrant Street Transportation Center3:20 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 12/15/2025 1:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/15/2025 3:20:00 PM. 50 Economy ticket for $70 per person are available. Travel duration is 14h 45m
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Greyhound US13h 35m010:50 AMPittsburghGrant Street Transportation Center11:25 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 12/15/2025 10:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/15/2025 11:25:00 PM. 50 Economy ticket for $70 per person are available. Travel duration is 13h 35m
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Greyhound US12h 55m08:00 PMPittsburghGrant Street Transportation Center7:55 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 12/15/2025 8:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/16/2025 7:55:00 AM. 50 Economy ticket for $76 per person are available. Travel duration is 12h 55m
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United Airlines5h 50m06:00 AMPittsburgh AirportPittsburgh Airport10:50 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 12/15/2025 6:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/15/2025 10:50:00 AM. 50 Economy ticket for $447 per person are available. Travel duration is 5h 50m
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Skyscanner7h 42m05:00 PMPittsburgh AirportPittsburgh Airport11:42 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 12/15/2025 5:00:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/15/2025 11:42:00 PM. 50 Economy ticket for $447 per person are available. Travel duration is 7h 42m
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Skyscanner6h 10m06:32 PMPittsburgh AirportPittsburgh Airport11:42 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 12/15/2025 6:32:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/15/2025 11:42:00 PM. 50 Economy ticket for $447 per person are available. Travel duration is 6h 10m
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Alaska Airlines19h 54m07:33 PMPittsburgh AirportPittsburgh Airport2:27 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Alaska Airlines goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 12/15/2025 7:33:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/16/2025 2:27:00 PM. 50 Economy ticket for $646 per person are available. Travel duration is 19h 54m
Cheapest Buses Monday
Cheapest Flights Monday
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Greyhound US14h 45m01:35 AMPittsburghGrant Street Transportation Center3:20 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 12/16/2025 1:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/16/2025 3:20:00 PM. 50 Economy ticket for $71 per person are available. Travel duration is 14h 45m
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Greyhound US12h 55m08:00 PMPittsburghGrant Street Transportation Center7:55 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 12/16/2025 8:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/17/2025 7:55:00 AM. 50 Economy ticket for $73 per person are available. Travel duration is 12h 55m
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Greyhound US13h 35m010:50 AMPittsburghGrant Street Transportation Center11:25 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 12/16/2025 10:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/16/2025 11:25:00 PM. 50 Economy ticket for $94 per person are available. Travel duration is 13h 35m
Cheapest Buses Tuesday
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Spirit Airlines17h 23m06:10 AMPittsburgh AirportPittsburgh Airport10:33 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 12/18/2025 6:10:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/18/2025 10:33:00 PM. 50 Economy ticket for $210 per person are available. Travel duration is 17h 23m
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Allegiant Air26h 54m05:48 PMPittsburgh AirportPittsburgh Airport7:42 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Allegiant Air goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 12/18/2025 5:48:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/19/2025 7:42:00 PM. 50 Economy ticket for $241 per person are available. Travel duration is 26h 54m
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Skyscanner5h 8m06:00 AMPittsburgh AirportPittsburgh Airport10:08 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 12/18/2025 6:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/18/2025 10:08:00 AM. 50 Economy ticket for $320 per person are available. Travel duration is 5h 8m
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United Airlines6h 52m06:35 AMPittsburgh AirportPittsburgh Airport12:27 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 12/18/2025 6:35:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/18/2025 12:27:00 PM. 50 Economy ticket for $320 per person are available. Travel duration is 6h 52m
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Alaska Airlines29h 5m07:54 PMPittsburgh AirportPittsburgh Airport11:59 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Alaska Airlines goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 12/18/2025 7:54:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/19/2025 11:59:00 PM. 50 Economy ticket for $759 per person are available. Travel duration is 29h 5m
Cheapest Flights Thursday
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Allegiant Air29h 33m06:00 PMPittsburgh AirportPittsburgh Airport10:33 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Allegiant Air goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 12/20/2025 6:00:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/21/2025 10:33:00 PM. 50 Economy ticket for $227 per person are available. Travel duration is 29h 33m
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Spirit Airlines27h 56m08:00 AMPittsburgh AirportPittsburgh Airport10:56 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 12/20/2025 8:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/21/2025 10:56:00 AM. 50 Economy ticket for $244 per person are available. Travel duration is 27h 56m
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United Airlines6h 52m06:35 AMPittsburgh AirportPittsburgh Airport12:27 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 12/20/2025 6:35:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/20/2025 12:27:00 PM. 50 Economy ticket for $250 per person are available. Travel duration is 6h 52m
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United Airlines4h 58m05:45 PMPittsburgh AirportPittsburgh Airport9:43 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 12/20/2025 5:45:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/20/2025 9:43:00 PM. 50 Economy ticket for $250 per person are available. Travel duration is 4h 58m
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Skyscanner4h 42m08:45 AMPittsburgh AirportPittsburgh Airport12:27 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 12/20/2025 8:45:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/20/2025 12:27:00 PM. 50 Economy ticket for $250 per person are available. Travel duration is 4h 42m
Cheapest Flights Saturday
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Greyhound US14h 45m01:35 AMPittsburghGrant Street Transportation Center3:20 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 12/21/2025 1:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/21/2025 3:20:00 PM. 50 Economy ticket for $100 per person are available. Travel duration is 14h 45m
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Greyhound US12h 55m08:00 PMPittsburghGrant Street Transportation Center7:55 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 12/21/2025 8:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/22/2025 7:55:00 AM. 50 Economy ticket for $100 per person are available. Travel duration is 12h 55m
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Greyhound US13h 35m010:50 AMPittsburghGrant Street Transportation Center11:25 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 12/21/2025 10:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/21/2025 11:25:00 PM. 50 Economy ticket for $165 per person are available. Travel duration is 13h 35m
Cheapest Buses Sunday
What are the fastest trips from Pittsburgh to St. Louis, MO?
You can get to St. Louis, MO from Pittsburgh in just 4h 42m with a Flight from Skyscanner. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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United Airlines5h 50m06:00 AMPittsburgh AirportPittsburgh Airport10:50 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 12/15/2025 6:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/15/2025 10:50:00 AM. 50 Economy ticket for $447 per person are available. Travel duration is 5h 50m
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Skyscanner6h 10m06:32 PMPittsburgh AirportPittsburgh Airport11:42 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 12/15/2025 6:32:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/15/2025 11:42:00 PM. 50 Economy ticket for $447 per person are available. Travel duration is 6h 10m
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Skyscanner7h 42m05:00 PMPittsburgh AirportPittsburgh Airport11:42 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 12/15/2025 5:00:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/15/2025 11:42:00 PM. 50 Economy ticket for $447 per person are available. Travel duration is 7h 42m
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Alaska Airlines19h 54m07:33 PMPittsburgh AirportPittsburgh Airport2:27 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Alaska Airlines goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 12/15/2025 7:33:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/16/2025 2:27:00 PM. 50 Economy ticket for $646 per person are available. Travel duration is 19h 54m
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Greyhound US12h 55m08:00 PMPittsburghGrant Street Transportation Center7:55 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 12/15/2025 8:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/16/2025 7:55:00 AM. 50 Economy ticket for $76 per person are available. Travel duration is 12h 55m
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Greyhound US13h 35m010:50 AMPittsburghGrant Street Transportation Center11:25 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 12/15/2025 10:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/15/2025 11:25:00 PM. 50 Economy ticket for $70 per person are available. Travel duration is 13h 35m
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Greyhound US14h 45m01:35 AMPittsburghGrant Street Transportation Center3:20 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 12/15/2025 1:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/15/2025 3:20:00 PM. 50 Economy ticket for $70 per person are available. Travel duration is 14h 45m
Fastest Flights Monday
Fastest Buses Monday
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Greyhound US12h 55m08:00 PMPittsburghGrant Street Transportation Center7:55 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 12/16/2025 8:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/17/2025 7:55:00 AM. 50 Economy ticket for $73 per person are available. Travel duration is 12h 55m
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Greyhound US13h 35m010:50 AMPittsburghGrant Street Transportation Center11:25 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 12/16/2025 10:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/16/2025 11:25:00 PM. 50 Economy ticket for $94 per person are available. Travel duration is 13h 35m
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Greyhound US14h 45m01:35 AMPittsburghGrant Street Transportation Center3:20 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 12/16/2025 1:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/16/2025 3:20:00 PM. 50 Economy ticket for $71 per person are available. Travel duration is 14h 45m
Fastest Buses Tuesday
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Skyscanner5h 8m06:00 AMPittsburgh AirportPittsburgh Airport10:08 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 12/18/2025 6:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/18/2025 10:08:00 AM. 50 Economy ticket for $320 per person are available. Travel duration is 5h 8m
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United Airlines6h 52m06:35 AMPittsburgh AirportPittsburgh Airport12:27 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 12/18/2025 6:35:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/18/2025 12:27:00 PM. 50 Economy ticket for $320 per person are available. Travel duration is 6h 52m
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Spirit Airlines17h 23m06:10 AMPittsburgh AirportPittsburgh Airport10:33 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 12/18/2025 6:10:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/18/2025 10:33:00 PM. 50 Economy ticket for $210 per person are available. Travel duration is 17h 23m
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Allegiant Air26h 54m05:48 PMPittsburgh AirportPittsburgh Airport7:42 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Allegiant Air goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 12/18/2025 5:48:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/19/2025 7:42:00 PM. 50 Economy ticket for $241 per person are available. Travel duration is 26h 54m
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Alaska Airlines29h 5m07:54 PMPittsburgh AirportPittsburgh Airport11:59 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Alaska Airlines goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 12/18/2025 7:54:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/19/2025 11:59:00 PM. 50 Economy ticket for $759 per person are available. Travel duration is 29h 5m
Fastest Flights Thursday
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Skyscanner4h 42m08:45 AMPittsburgh AirportPittsburgh Airport12:27 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 12/20/2025 8:45:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/20/2025 12:27:00 PM. 50 Economy ticket for $250 per person are available. Travel duration is 4h 42m
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United Airlines4h 58m05:45 PMPittsburgh AirportPittsburgh Airport9:43 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 12/20/2025 5:45:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/20/2025 9:43:00 PM. 50 Economy ticket for $250 per person are available. Travel duration is 4h 58m
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United Airlines6h 52m06:35 AMPittsburgh AirportPittsburgh Airport12:27 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 12/20/2025 6:35:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/20/2025 12:27:00 PM. 50 Economy ticket for $250 per person are available. Travel duration is 6h 52m
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Spirit Airlines27h 56m08:00 AMPittsburgh AirportPittsburgh Airport10:56 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 12/20/2025 8:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/21/2025 10:56:00 AM. 50 Economy ticket for $244 per person are available. Travel duration is 27h 56m
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Allegiant Air29h 33m06:00 PMPittsburgh AirportPittsburgh Airport10:33 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Allegiant Air goes from Pittsburgh Airport, Pittsburgh Airport (USA) at 12/20/2025 6:00:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/21/2025 10:33:00 PM. 50 Economy ticket for $227 per person are available. Travel duration is 29h 33m
Fastest Flights Saturday
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Greyhound US12h 55m08:00 PMPittsburghGrant Street Transportation Center7:55 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 12/21/2025 8:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/22/2025 7:55:00 AM. 50 Economy ticket for $100 per person are available. Travel duration is 12h 55m
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Greyhound US13h 35m010:50 AMPittsburghGrant Street Transportation Center11:25 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 12/21/2025 10:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/21/2025 11:25:00 PM. 50 Economy ticket for $165 per person are available. Travel duration is 13h 35m
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Greyhound US14h 45m01:35 AMPittsburghGrant Street Transportation Center3:20 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Grant Street Transportation Center, Pittsburgh (USA) at 12/21/2025 1:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/21/2025 3:20:00 PM. 50 Economy ticket for $100 per person are available. Travel duration is 14h 45m
Fastest Buses Sunday
Here you will find all operators and timetables for a
Bus from Pittsburgh to St. Louis, MO
What are the most popular stations in Pittsburgh and St. Louis, MO?
In Pittsburgh, you will usually depart from Grant Street Transportation Center, David L. Lawrence Convention Center or Central Station, while in St. Louis, MO you will be arriving at Gateway Station, Lindbergh @ Hackberry NB Bus Stop or Skinker Boulevard, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to St. Louis, MO from Pittsburgh? With 5 connections between 1 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Pittsburgh and St. Louis, MO, you can pay as low as $70 with a Bus from Greyhound US.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from Skyscanner: you will get to St. Louis, MO in just 4h 42m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Pittsburgh and St. Louis, MO are Greyhound US, United Airlines and Skyscanner, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Pittsburgh and St. Louis, MO is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Green Tree, PA or to Sauget, IL, and look at flights from Pittsburgh Airport, and landing at St. Louis Lambert Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Pittsburgh to St. Louis, MO?
The most popular companies between Pittsburgh and St. Louis, MO, are Greyhound US, United Airlines and Skyscanner. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Greyhound US
Airlines: United Airlines, Skyscanner, Alaska Airlines and 2 more.
All you need to know when you travel from Pittsburgh to St. Louis, MO
Check all information on comfort and services on all modes of transports from Pittsburgh to St. Louis, MO. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Pittsburgh to St. Louis, MO
How can I reach St. Louis, MO from Pittsburgh?
Every day, there are on average 5 connections between Bus and Flight, with which you can get to St. Louis, MO from Pittsburgh.
How far is St. Louis, MO from Pittsburgh?
The distance between Pittsburgh and St. Louis, MO is 558.2 miles.
What is the most ecofriendly mode of transport between Pittsburgh and St. Louis, MO?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 24 kgs of CO2, a train 31 kgs, a car 153 kgs, and a flight 221 kgs.
What is the cheapest mode of transport from Pittsburgh to St. Louis, MO?
You can get to St. Louis, MO with just $70 by taking a Bus from Greyhound US.
What is the fastest way to get from Pittsburgh to St. Louis, MO?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to St. Louis, MO in just 4h 42m with a Flight from Skyscanner.
More routes to Pittsburgh and to St. Louis, MO
Looking for more options? Here you can see the most popular routes to Pittsburgh and to St. Louis, MO. Simply click on a connection, and you’ll find all the details about the route!

