How to get from San Diego to St. Louis, MO

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What is the best way to travel from San Diego to St. Louis, MO?

Looking for a trip? Compare all the available Buses and Flights for the journey to St. Louis, MO from San Diego. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
Flight is the cheapest and fastest way on this route
Transport type
Travel time
Cheapest price
Average price
Daily departures
Bus
45h 5m
$186
$248
12
Flight
6h 38m
$134
$311
66

What is the cheapest way to reach St. Louis, MO from San Diego?

You can get to St. Louis, MO with just $134 by taking a Flight from Frontier Airlines, but you can find many more cheap offers: we have selected the best ones for next few days here for you.

Friday
from $164
Saturday
from $234
Sunday
from $186
Monday
from $344
Tuesday
from $135
Wednesday
from $233
Thursday
from $134

    Cheapest Flights Friday

  • Frontier Airlines
    24h 46m
    0
    6:25 AM
    San Diego Airport
    San Diego Airport
    9:11 AM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Frontier Airlines
    Economy
    from $164
  • United Airlines
    7h 46m
    0
    6:45 AM
    San Diego Airport
    San Diego Airport
    4:31 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    United Airlines
    Economy
    from $175
  • American Airlines
    8h 25m
    0
    6:15 AM
    San Diego Airport
    San Diego Airport
    4:40 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    American Airlines
    Economy
    from $375
  • Alaska Airlines
    11h 54m
    0
    7:00 AM
    San Diego Airport
    San Diego Airport
    8:54 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Alaska Airlines
    Economy
    from $503
  • Aeroméxico
    14h 19m
    0
    2:25 AM
    Tijuana Airport
    Tijuana Airport
    6:44 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Aeroméxico
    Economy
    from $644

    Cheapest Buses Saturday

  • Greyhound Lines Mexico
    50h 25m
    0
    10:30 AM
    Tijuana Airport
    Tijuana Airport
    12:55 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound Lines Mexico
    Economy
    $234
  • FlixBus
    51h 40m
    0
    7:00 PM
    San Diego
    La Jolla Village
    10:40 PM
    St. Louis, MO
    Gateway Station
    0
    FlixBus
    Economy
    $309
  • Greyhound US
    51h 5m
    0
    7:35 PM
    San Diego
    Old Town Transit Center
    10:40 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $309
  • FlixBus
    52h 5m
    0
    6:35 PM
    San Diego
    Old Town Transit Center
    10:40 PM
    St. Louis, MO
    Gateway Station
    0
    FlixBus
    Economy
    $312
  • Greyhound US
    46h 55m
    0
    2:00 PM
    San Diego
    Old Town Transit Center
    12:55 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $317
  • Cheapest Flights Saturday

  • Frontier Airlines
    16h 36m
    0
    7:06 PM
    San Diego Airport
    San Diego Airport
    1:42 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Frontier Airlines
    Economy
    from $247
  • United Airlines
    7h 12m
    0
    6:35 AM
    San Diego Airport
    San Diego Airport
    3:47 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    United Airlines
    Economy
    from $270
  • American Airlines
    8h 15m
    0
    8:18 AM
    San Diego Airport
    San Diego Airport
    6:33 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    American Airlines
    Economy
    from $368
  • Alaska Airlines
    10h 13m
    0
    10:00 AM
    San Diego Airport
    San Diego Airport
    10:13 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Alaska Airlines
    Economy
    from $375
  • Spirit Airlines
    21h 12m
    0
    2:30 PM
    San Diego Airport
    San Diego Airport
    1:42 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Spirit Airlines
    Economy
    from $380

    Cheapest Buses Sunday

  • FlixBus
    51h 40m
    0
    7:00 PM
    San Diego
    La Jolla Village
    10:40 PM
    St. Louis, MO
    Gateway Station
    0
    FlixBus
    Economy
    $186
  • Greyhound US
    51h 5m
    0
    7:35 PM
    San Diego
    Old Town Transit Center
    10:40 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $186
  • FlixBus
    52h 5m
    0
    6:35 PM
    San Diego
    Old Town Transit Center
    10:40 PM
    St. Louis, MO
    Gateway Station
    0
    FlixBus
    Economy
    $188
  • Greyhound US
    45h 5m
    0
    10:00 AM
    San Diego
    Old Town Transit Center
    7:05 AM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $203
  • Greyhound Lines Mexico
    50h 25m
    0
    10:30 AM
    Tijuana Airport
    Tijuana Airport
    12:55 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound Lines Mexico
    Economy
    $254

    Cheapest Flights Monday

  • American Airlines
    8h 15m
    0
    8:18 AM
    San Diego Airport
    San Diego Airport
    6:33 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    American Airlines
    Economy
    from $344
  • American Airlines
    6h 38m
    0
    9:55 AM
    San Diego Airport
    San Diego Airport
    6:33 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    American Airlines
    Economy
    from $344
  • United Airlines
    7h 46m
    0
    6:45 AM
    San Diego Airport
    San Diego Airport
    4:31 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    United Airlines
    Economy
    from $347
  • United Airlines
    9h 4m
    0
    5:50 PM
    San Diego Airport
    San Diego Airport
    4:54 AM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    United Airlines
    Economy
    from $347
  • Alaska Airlines
    12h 5m
    0
    5:51 PM
    San Diego Airport
    San Diego Airport
    7:56 AM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Alaska Airlines
    Economy
    from $360

    Cheapest Flights Tuesday

  • Frontier Airlines
    24h 46m
    0
    6:25 AM
    San Diego Airport
    San Diego Airport
    9:11 AM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Frontier Airlines
    Economy
    from $135
  • Spirit Airlines
    12h 58m
    0
    7:31 PM
    San Diego Airport
    San Diego Airport
    10:29 AM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Spirit Airlines
    Economy
    from $167
  • Alaska Airlines
    10h 20m
    0
    6:15 AM
    San Diego Airport
    San Diego Airport
    6:35 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Alaska Airlines
    Economy
    from $251
  • United Airlines
    8h 44m
    0
    6:15 AM
    San Diego Airport
    San Diego Airport
    4:59 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    United Airlines
    Economy
    from $271
  • American Airlines
    8h 32m
    0
    6:15 AM
    San Diego Airport
    San Diego Airport
    4:47 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    American Airlines
    Economy
    from $338
  • Cheapest Buses Tuesday

  • Greyhound Lines Mexico
    50h 25m
    0
    10:30 AM
    Tijuana Airport
    Tijuana Airport
    12:55 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound Lines Mexico
    Economy
    $246

    Cheapest Buses Wednesday

  • Greyhound Lines Mexico
    50h 25m
    0
    10:30 AM
    Tijuana Airport
    Tijuana Airport
    12:55 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound Lines Mexico
    Economy
    $233

    Cheapest Flights Thursday

  • Frontier Airlines
    10h 58m
    0
    6:25 AM
    San Diego Airport
    San Diego Airport
    7:23 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Frontier Airlines
    Economy
    from $134
  • Spirit Airlines
    14h 2m
    0
    9:40 PM
    San Diego Airport
    San Diego Airport
    1:42 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Spirit Airlines
    Economy
    from $231
  • Alaska Airlines
    10h 20m
    0
    6:15 AM
    San Diego Airport
    San Diego Airport
    6:35 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Alaska Airlines
    Economy
    from $319
  • American Airlines
    8h 32m
    0
    6:15 AM
    San Diego Airport
    San Diego Airport
    4:47 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    American Airlines
    Economy
    from $338
  • United Airlines
    8h 44m
    0
    6:15 AM
    San Diego Airport
    San Diego Airport
    4:59 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    United Airlines
    Economy
    from $347

What are the fastest trips from San Diego to St. Louis, MO?

You can get to St. Louis, MO from San Diego in just 6h 38m with a Flight from American Airlines. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.

Friday
from 7h 46m
Saturday
from 7h 12m
Sunday
from 45h 5m
Monday
from 6h 38m
Tuesday
from 8h 32m
Wednesday
from 50h 25m
Thursday
from 8h 32m

    Fastest Flights Friday

  • United Airlines
    7h 46m
    0
    6:45 AM
    San Diego Airport
    San Diego Airport
    4:31 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    United Airlines
    Economy
    from $175
  • American Airlines
    8h 25m
    0
    6:15 AM
    San Diego Airport
    San Diego Airport
    4:40 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    American Airlines
    Economy
    from $375
  • Alaska Airlines
    11h 54m
    0
    7:00 AM
    San Diego Airport
    San Diego Airport
    8:54 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Alaska Airlines
    Economy
    from $503
  • Aeroméxico
    14h 19m
    0
    2:25 AM
    Tijuana Airport
    Tijuana Airport
    6:44 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Aeroméxico
    Economy
    from $644
  • Frontier Airlines
    24h 46m
    0
    6:25 AM
    San Diego Airport
    San Diego Airport
    9:11 AM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Frontier Airlines
    Economy
    from $164

    Fastest Flights Saturday

  • United Airlines
    7h 12m
    0
    6:35 AM
    San Diego Airport
    San Diego Airport
    3:47 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    United Airlines
    Economy
    from $270
  • American Airlines
    8h 15m
    0
    8:18 AM
    San Diego Airport
    San Diego Airport
    6:33 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    American Airlines
    Economy
    from $368
  • Alaska Airlines
    10h 13m
    0
    10:00 AM
    San Diego Airport
    San Diego Airport
    10:13 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Alaska Airlines
    Economy
    from $375
  • Frontier Airlines
    16h 36m
    0
    7:06 PM
    San Diego Airport
    San Diego Airport
    1:42 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Frontier Airlines
    Economy
    from $247
  • Spirit Airlines
    21h 12m
    0
    2:30 PM
    San Diego Airport
    San Diego Airport
    1:42 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Spirit Airlines
    Economy
    from $380
  • Fastest Buses Saturday

  • Greyhound US
    46h 55m
    0
    2:00 PM
    San Diego
    Old Town Transit Center
    12:55 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $317
  • Greyhound Lines Mexico
    50h 25m
    0
    10:30 AM
    Tijuana Airport
    Tijuana Airport
    12:55 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound Lines Mexico
    Economy
    $234
  • Greyhound US
    51h 5m
    0
    7:35 PM
    San Diego
    Old Town Transit Center
    10:40 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $309
  • FlixBus
    51h 40m
    0
    7:00 PM
    San Diego
    La Jolla Village
    10:40 PM
    St. Louis, MO
    Gateway Station
    0
    FlixBus
    Economy
    $309
  • FlixBus
    52h 5m
    0
    6:35 PM
    San Diego
    Old Town Transit Center
    10:40 PM
    St. Louis, MO
    Gateway Station
    0
    FlixBus
    Economy
    $312

    Fastest Buses Sunday

  • Greyhound US
    45h 5m
    0
    10:00 AM
    San Diego
    Old Town Transit Center
    7:05 AM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $203
  • Greyhound Lines Mexico
    50h 25m
    0
    10:30 AM
    Tijuana Airport
    Tijuana Airport
    12:55 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound Lines Mexico
    Economy
    $254
  • Greyhound US
    51h 5m
    0
    7:35 PM
    San Diego
    Old Town Transit Center
    10:40 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $186
  • FlixBus
    51h 40m
    0
    7:00 PM
    San Diego
    La Jolla Village
    10:40 PM
    St. Louis, MO
    Gateway Station
    0
    FlixBus
    Economy
    $186
  • FlixBus
    52h 5m
    0
    6:35 PM
    San Diego
    Old Town Transit Center
    10:40 PM
    St. Louis, MO
    Gateway Station
    0
    FlixBus
    Economy
    $188

    Fastest Flights Monday

  • American Airlines
    6h 38m
    0
    9:55 AM
    San Diego Airport
    San Diego Airport
    6:33 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    American Airlines
    Economy
    from $344
  • United Airlines
    7h 46m
    0
    6:45 AM
    San Diego Airport
    San Diego Airport
    4:31 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    United Airlines
    Economy
    from $347
  • American Airlines
    8h 15m
    0
    8:18 AM
    San Diego Airport
    San Diego Airport
    6:33 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    American Airlines
    Economy
    from $344
  • United Airlines
    9h 4m
    0
    5:50 PM
    San Diego Airport
    San Diego Airport
    4:54 AM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    United Airlines
    Economy
    from $347
  • Alaska Airlines
    12h 5m
    0
    5:51 PM
    San Diego Airport
    San Diego Airport
    7:56 AM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Alaska Airlines
    Economy
    from $360

    Fastest Flights Tuesday

  • American Airlines
    8h 32m
    0
    6:15 AM
    San Diego Airport
    San Diego Airport
    4:47 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    American Airlines
    Economy
    from $338
  • United Airlines
    8h 44m
    0
    6:15 AM
    San Diego Airport
    San Diego Airport
    4:59 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    United Airlines
    Economy
    from $271
  • Alaska Airlines
    10h 20m
    0
    6:15 AM
    San Diego Airport
    San Diego Airport
    6:35 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Alaska Airlines
    Economy
    from $251
  • Spirit Airlines
    12h 58m
    0
    7:31 PM
    San Diego Airport
    San Diego Airport
    10:29 AM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Spirit Airlines
    Economy
    from $167
  • Frontier Airlines
    24h 46m
    0
    6:25 AM
    San Diego Airport
    San Diego Airport
    9:11 AM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Frontier Airlines
    Economy
    from $135
  • Fastest Buses Tuesday

  • Greyhound Lines Mexico
    50h 25m
    0
    10:30 AM
    Tijuana Airport
    Tijuana Airport
    12:55 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound Lines Mexico
    Economy
    $246

    Fastest Buses Wednesday

  • Greyhound Lines Mexico
    50h 25m
    0
    10:30 AM
    Tijuana Airport
    Tijuana Airport
    12:55 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound Lines Mexico
    Economy
    $233

    Fastest Flights Thursday

  • American Airlines
    8h 32m
    0
    6:15 AM
    San Diego Airport
    San Diego Airport
    4:47 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    American Airlines
    Economy
    from $338
  • United Airlines
    8h 44m
    0
    6:15 AM
    San Diego Airport
    San Diego Airport
    4:59 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    United Airlines
    Economy
    from $347
  • Alaska Airlines
    10h 20m
    0
    6:15 AM
    San Diego Airport
    San Diego Airport
    6:35 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Alaska Airlines
    Economy
    from $319
  • Frontier Airlines
    10h 58m
    0
    6:25 AM
    San Diego Airport
    San Diego Airport
    7:23 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Frontier Airlines
    Economy
    from $134
  • Spirit Airlines
    14h 2m
    0
    9:40 PM
    San Diego Airport
    San Diego Airport
    1:42 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Spirit Airlines
    Economy
    from $231
Here you will find all operators and timetables for a Bus from San Diego to St. Louis, MO

What are the most popular stations in San Diego and St. Louis, MO?

In San Diego, you will usually depart from Santa Fe Depot, San Ysidro Transit Center or Old Town Transit Center, while in St. Louis, MO you will be arriving at Gateway Station, Lindbergh @ Hackberry NB Bus Stop or Skinker Boulevard, but there are many more stops to explore in both locations.

How do I decide? Some tips and tricks from our experience

Are you having trouble deciding on how to get to St. Louis, MO from San Diego? With 5 connections between 2 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.

Look for the lowest price

Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between San Diego and St. Louis, MO, you can pay as low as $134 with a Flight from Frontier Airlines.

Travel duration

Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from American Airlines: you will get to St. Louis, MO in just 6h 38m.

Comfort makes all the difference

You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting San Diego and St. Louis, MO are United Airlines, American Airlines and Alaska Airlines, but be sure to check what they have to offer!

Save money with deals, and always compare

One last tip? Even if you live in San Diego and St. Louis, MO is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from San Diego Airport or to Sauget, IL, and look at flights from Tijuana Airport, and landing at St. Louis Lambert Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!

Which companies offer a trip from San Diego to St. Louis, MO?

The most popular companies between San Diego and St. Louis, MO, are United Airlines, American Airlines and Alaska Airlines. Be sure to check their seat class offers and the amenities that they provide.

Bus companies: Greyhound Lines Mexico, FlixBus and Greyhound US

Airlines: United Airlines, American Airlines, Alaska Airlines and 3 more.

All you need to know when you travel from San Diego to St. Louis, MO

Check all information on comfort and services on all modes of transports from San Diego to St. Louis, MO. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.

FAQs about the trip from San Diego to St. Louis, MO

How can I reach St. Louis, MO from San Diego?

Every day, there are on average 5 connections between Bus and Flight, with which you can get to St. Louis, MO from San Diego.

How far is St. Louis, MO from San Diego?

The distance between San Diego and St. Louis, MO is 1,560.7 miles.

What is the most ecofriendly mode of transport between San Diego and St. Louis, MO?

Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance. On this particular route, a bus will emit, per person, a total of 68 kgs of CO2, a train 88 kgs, a car 427 kgs, and a flight 618 kgs.

What is the cheapest mode of transport from San Diego to St. Louis, MO?

You can get to St. Louis, MO with just $134 by taking a Flight from Frontier Airlines.

What is the fastest way to get from San Diego to St. Louis, MO?

While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to St. Louis, MO in just 6h 38m with a Flight from American Airlines.

More routes to San Diego and to St. Louis, MO

Looking for more options? Here you can see the most popular routes to San Diego and to St. Louis, MO. Simply click on a connection, and you’ll find all the details about the route!

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