What is the best way to travel from San Diego to St. Louis, MO?
Looking for a trip? Compare all the available Buses and Flights for the journey to St. Louis, MO from San Diego. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
What is the cheapest way to reach St. Louis, MO from San Diego?
You can get to St. Louis, MO with just $134 by taking a Flight from Frontier Airlines, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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Frontier Airlines24h 46m06:25 AMSan Diego AirportSan Diego Airport9:11 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/4/2025 6:25:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/5/2025 9:11:00 AM. 50 Economy ticket for $164 per person are available. Travel duration is 24h 46m
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United Airlines7h 46m06:45 AMSan Diego AirportSan Diego Airport4:31 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/4/2025 6:45:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/4/2025 4:31:00 PM. 50 Economy ticket for $175 per person are available. Travel duration is 7h 46m
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American Airlines8h 25m06:15 AMSan Diego AirportSan Diego Airport4:40 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from American Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/4/2025 6:15:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/4/2025 4:40:00 PM. 50 Economy ticket for $375 per person are available. Travel duration is 8h 25m
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Alaska Airlines11h 54m07:00 AMSan Diego AirportSan Diego Airport8:54 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Alaska Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/4/2025 7:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/4/2025 8:54:00 PM. 50 Economy ticket for $503 per person are available. Travel duration is 11h 54m
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Aeroméxico14h 19m02:25 AMTijuana AirportTijuana Airport6:44 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Aeroméxico goes from Tijuana Airport, Tijuana Airport (Mexico) at 7/4/2025 2:25:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/4/2025 6:44:00 PM. 50 Economy ticket for $644 per person are available. Travel duration is 14h 19m
Cheapest Flights Friday
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Greyhound Lines Mexico50h 25m010:30 AMTijuana AirportTijuana Airport12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound Lines Mexico goes from Tijuana Airport, Tijuana Airport (Mexico) at 7/5/2025 10:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/7/2025 12:55:00 PM. 50 Economy ticket for $234 per person are available. Travel duration is 50h 25m
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FlixBus51h 40m07:00 PMSan DiegoLa Jolla Village10:40 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from La Jolla Village, San Diego (USA) at 7/5/2025 7:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/7/2025 10:40:00 PM. 50 Economy ticket for $309 per person are available. Travel duration is 51h 40m
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Greyhound US51h 5m07:35 PMSan DiegoOld Town Transit Center10:40 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 7/5/2025 7:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/7/2025 10:40:00 PM. 50 Economy ticket for $309 per person are available. Travel duration is 51h 5m
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FlixBus52h 5m06:35 PMSan DiegoOld Town Transit Center10:40 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 7/5/2025 6:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/7/2025 10:40:00 PM. 50 Economy ticket for $312 per person are available. Travel duration is 52h 5m
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Greyhound US46h 55m02:00 PMSan DiegoOld Town Transit Center12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 7/5/2025 2:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/7/2025 12:55:00 PM. 50 Economy ticket for $317 per person are available. Travel duration is 46h 55m
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Frontier Airlines16h 36m07:06 PMSan Diego AirportSan Diego Airport1:42 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/5/2025 7:06:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/6/2025 1:42:00 PM. 50 Economy ticket for $247 per person are available. Travel duration is 16h 36m
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United Airlines7h 12m06:35 AMSan Diego AirportSan Diego Airport3:47 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/5/2025 6:35:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/5/2025 3:47:00 PM. 50 Economy ticket for $270 per person are available. Travel duration is 7h 12m
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American Airlines8h 15m08:18 AMSan Diego AirportSan Diego Airport6:33 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from American Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/5/2025 8:18:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/5/2025 6:33:00 PM. 50 Economy ticket for $368 per person are available. Travel duration is 8h 15m
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Alaska Airlines10h 13m010:00 AMSan Diego AirportSan Diego Airport10:13 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Alaska Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/5/2025 10:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/5/2025 10:13:00 PM. 50 Economy ticket for $375 per person are available. Travel duration is 10h 13m
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Spirit Airlines21h 12m02:30 PMSan Diego AirportSan Diego Airport1:42 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/5/2025 2:30:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/6/2025 1:42:00 PM. 50 Economy ticket for $380 per person are available. Travel duration is 21h 12m
Cheapest Buses Saturday
Cheapest Flights Saturday
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FlixBus51h 40m07:00 PMSan DiegoLa Jolla Village10:40 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from La Jolla Village, San Diego (USA) at 7/6/2025 7:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/8/2025 10:40:00 PM. 50 Economy ticket for $186 per person are available. Travel duration is 51h 40m
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Greyhound US51h 5m07:35 PMSan DiegoOld Town Transit Center10:40 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 7/6/2025 7:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/8/2025 10:40:00 PM. 50 Economy ticket for $186 per person are available. Travel duration is 51h 5m
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FlixBus52h 5m06:35 PMSan DiegoOld Town Transit Center10:40 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 7/6/2025 6:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/8/2025 10:40:00 PM. 50 Economy ticket for $188 per person are available. Travel duration is 52h 5m
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Greyhound US45h 5m010:00 AMSan DiegoOld Town Transit Center7:05 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 7/6/2025 10:00:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/8/2025 7:05:00 AM. 50 Economy ticket for $203 per person are available. Travel duration is 45h 5m
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Greyhound Lines Mexico50h 25m010:30 AMTijuana AirportTijuana Airport12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound Lines Mexico goes from Tijuana Airport, Tijuana Airport (Mexico) at 7/6/2025 10:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/8/2025 12:55:00 PM. 50 Economy ticket for $254 per person are available. Travel duration is 50h 25m
Cheapest Buses Sunday
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American Airlines8h 15m08:18 AMSan Diego AirportSan Diego Airport6:33 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from American Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/7/2025 8:18:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/7/2025 6:33:00 PM. 50 Economy ticket for $344 per person are available. Travel duration is 8h 15m
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American Airlines6h 38m09:55 AMSan Diego AirportSan Diego Airport6:33 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from American Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/7/2025 9:55:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/7/2025 6:33:00 PM. 50 Economy ticket for $344 per person are available. Travel duration is 6h 38m
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United Airlines7h 46m06:45 AMSan Diego AirportSan Diego Airport4:31 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/7/2025 6:45:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/7/2025 4:31:00 PM. 50 Economy ticket for $347 per person are available. Travel duration is 7h 46m
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United Airlines9h 4m05:50 PMSan Diego AirportSan Diego Airport4:54 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/7/2025 5:50:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/8/2025 4:54:00 AM. 50 Economy ticket for $347 per person are available. Travel duration is 9h 4m
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Alaska Airlines12h 5m05:51 PMSan Diego AirportSan Diego Airport7:56 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Alaska Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/7/2025 5:51:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/8/2025 7:56:00 AM. 50 Economy ticket for $360 per person are available. Travel duration is 12h 5m
Cheapest Flights Monday
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Frontier Airlines24h 46m06:25 AMSan Diego AirportSan Diego Airport9:11 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/8/2025 6:25:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/9/2025 9:11:00 AM. 50 Economy ticket for $135 per person are available. Travel duration is 24h 46m
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Spirit Airlines12h 58m07:31 PMSan Diego AirportSan Diego Airport10:29 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/8/2025 7:31:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/9/2025 10:29:00 AM. 50 Economy ticket for $167 per person are available. Travel duration is 12h 58m
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Alaska Airlines10h 20m06:15 AMSan Diego AirportSan Diego Airport6:35 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Alaska Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/8/2025 6:15:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/8/2025 6:35:00 PM. 50 Economy ticket for $251 per person are available. Travel duration is 10h 20m
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United Airlines8h 44m06:15 AMSan Diego AirportSan Diego Airport4:59 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/8/2025 6:15:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/8/2025 4:59:00 PM. 50 Economy ticket for $271 per person are available. Travel duration is 8h 44m
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American Airlines8h 32m06:15 AMSan Diego AirportSan Diego Airport4:47 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from American Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/8/2025 6:15:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/8/2025 4:47:00 PM. 50 Economy ticket for $338 per person are available. Travel duration is 8h 32m
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Greyhound Lines Mexico50h 25m010:30 AMTijuana AirportTijuana Airport12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound Lines Mexico goes from Tijuana Airport, Tijuana Airport (Mexico) at 7/8/2025 10:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/10/2025 12:55:00 PM. 50 Economy ticket for $246 per person are available. Travel duration is 50h 25m
Cheapest Flights Tuesday
Cheapest Buses Tuesday
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Greyhound Lines Mexico50h 25m010:30 AMTijuana AirportTijuana Airport12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound Lines Mexico goes from Tijuana Airport, Tijuana Airport (Mexico) at 7/9/2025 10:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/11/2025 12:55:00 PM. 50 Economy ticket for $233 per person are available. Travel duration is 50h 25m
Cheapest Buses Wednesday
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Frontier Airlines10h 58m06:25 AMSan Diego AirportSan Diego Airport7:23 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/10/2025 6:25:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/10/2025 7:23:00 PM. 50 Economy ticket for $134 per person are available. Travel duration is 10h 58m
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Spirit Airlines14h 2m09:40 PMSan Diego AirportSan Diego Airport1:42 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/10/2025 9:40:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/11/2025 1:42:00 PM. 50 Economy ticket for $231 per person are available. Travel duration is 14h 2m
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Alaska Airlines10h 20m06:15 AMSan Diego AirportSan Diego Airport6:35 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Alaska Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/10/2025 6:15:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/10/2025 6:35:00 PM. 50 Economy ticket for $319 per person are available. Travel duration is 10h 20m
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American Airlines8h 32m06:15 AMSan Diego AirportSan Diego Airport4:47 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from American Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/10/2025 6:15:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/10/2025 4:47:00 PM. 50 Economy ticket for $338 per person are available. Travel duration is 8h 32m
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United Airlines8h 44m06:15 AMSan Diego AirportSan Diego Airport4:59 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/10/2025 6:15:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/10/2025 4:59:00 PM. 50 Economy ticket for $347 per person are available. Travel duration is 8h 44m
Cheapest Flights Thursday
What are the fastest trips from San Diego to St. Louis, MO?
You can get to St. Louis, MO from San Diego in just 6h 38m with a Flight from American Airlines. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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United Airlines7h 46m06:45 AMSan Diego AirportSan Diego Airport4:31 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/4/2025 6:45:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/4/2025 4:31:00 PM. 50 Economy ticket for $175 per person are available. Travel duration is 7h 46m
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American Airlines8h 25m06:15 AMSan Diego AirportSan Diego Airport4:40 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from American Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/4/2025 6:15:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/4/2025 4:40:00 PM. 50 Economy ticket for $375 per person are available. Travel duration is 8h 25m
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Alaska Airlines11h 54m07:00 AMSan Diego AirportSan Diego Airport8:54 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Alaska Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/4/2025 7:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/4/2025 8:54:00 PM. 50 Economy ticket for $503 per person are available. Travel duration is 11h 54m
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Aeroméxico14h 19m02:25 AMTijuana AirportTijuana Airport6:44 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Aeroméxico goes from Tijuana Airport, Tijuana Airport (Mexico) at 7/4/2025 2:25:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/4/2025 6:44:00 PM. 50 Economy ticket for $644 per person are available. Travel duration is 14h 19m
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Frontier Airlines24h 46m06:25 AMSan Diego AirportSan Diego Airport9:11 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/4/2025 6:25:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/5/2025 9:11:00 AM. 50 Economy ticket for $164 per person are available. Travel duration is 24h 46m
Fastest Flights Friday
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United Airlines7h 12m06:35 AMSan Diego AirportSan Diego Airport3:47 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/5/2025 6:35:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/5/2025 3:47:00 PM. 50 Economy ticket for $270 per person are available. Travel duration is 7h 12m
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American Airlines8h 15m08:18 AMSan Diego AirportSan Diego Airport6:33 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from American Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/5/2025 8:18:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/5/2025 6:33:00 PM. 50 Economy ticket for $368 per person are available. Travel duration is 8h 15m
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Alaska Airlines10h 13m010:00 AMSan Diego AirportSan Diego Airport10:13 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Alaska Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/5/2025 10:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/5/2025 10:13:00 PM. 50 Economy ticket for $375 per person are available. Travel duration is 10h 13m
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Frontier Airlines16h 36m07:06 PMSan Diego AirportSan Diego Airport1:42 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/5/2025 7:06:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/6/2025 1:42:00 PM. 50 Economy ticket for $247 per person are available. Travel duration is 16h 36m
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Spirit Airlines21h 12m02:30 PMSan Diego AirportSan Diego Airport1:42 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/5/2025 2:30:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/6/2025 1:42:00 PM. 50 Economy ticket for $380 per person are available. Travel duration is 21h 12m
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Greyhound US46h 55m02:00 PMSan DiegoOld Town Transit Center12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 7/5/2025 2:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/7/2025 12:55:00 PM. 50 Economy ticket for $317 per person are available. Travel duration is 46h 55m
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Greyhound Lines Mexico50h 25m010:30 AMTijuana AirportTijuana Airport12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound Lines Mexico goes from Tijuana Airport, Tijuana Airport (Mexico) at 7/5/2025 10:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/7/2025 12:55:00 PM. 50 Economy ticket for $234 per person are available. Travel duration is 50h 25m
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Greyhound US51h 5m07:35 PMSan DiegoOld Town Transit Center10:40 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 7/5/2025 7:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/7/2025 10:40:00 PM. 50 Economy ticket for $309 per person are available. Travel duration is 51h 5m
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FlixBus51h 40m07:00 PMSan DiegoLa Jolla Village10:40 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from La Jolla Village, San Diego (USA) at 7/5/2025 7:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/7/2025 10:40:00 PM. 50 Economy ticket for $309 per person are available. Travel duration is 51h 40m
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FlixBus52h 5m06:35 PMSan DiegoOld Town Transit Center10:40 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 7/5/2025 6:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/7/2025 10:40:00 PM. 50 Economy ticket for $312 per person are available. Travel duration is 52h 5m
Fastest Flights Saturday
Fastest Buses Saturday
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Greyhound US45h 5m010:00 AMSan DiegoOld Town Transit Center7:05 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 7/6/2025 10:00:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/8/2025 7:05:00 AM. 50 Economy ticket for $203 per person are available. Travel duration is 45h 5m
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Greyhound Lines Mexico50h 25m010:30 AMTijuana AirportTijuana Airport12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound Lines Mexico goes from Tijuana Airport, Tijuana Airport (Mexico) at 7/6/2025 10:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/8/2025 12:55:00 PM. 50 Economy ticket for $254 per person are available. Travel duration is 50h 25m
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Greyhound US51h 5m07:35 PMSan DiegoOld Town Transit Center10:40 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 7/6/2025 7:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/8/2025 10:40:00 PM. 50 Economy ticket for $186 per person are available. Travel duration is 51h 5m
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FlixBus51h 40m07:00 PMSan DiegoLa Jolla Village10:40 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from La Jolla Village, San Diego (USA) at 7/6/2025 7:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/8/2025 10:40:00 PM. 50 Economy ticket for $186 per person are available. Travel duration is 51h 40m
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FlixBus52h 5m06:35 PMSan DiegoOld Town Transit Center10:40 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 7/6/2025 6:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 7/8/2025 10:40:00 PM. 50 Economy ticket for $188 per person are available. Travel duration is 52h 5m
Fastest Buses Sunday
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American Airlines6h 38m09:55 AMSan Diego AirportSan Diego Airport6:33 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from American Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/7/2025 9:55:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/7/2025 6:33:00 PM. 50 Economy ticket for $344 per person are available. Travel duration is 6h 38m
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United Airlines7h 46m06:45 AMSan Diego AirportSan Diego Airport4:31 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/7/2025 6:45:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/7/2025 4:31:00 PM. 50 Economy ticket for $347 per person are available. Travel duration is 7h 46m
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American Airlines8h 15m08:18 AMSan Diego AirportSan Diego Airport6:33 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from American Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/7/2025 8:18:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/7/2025 6:33:00 PM. 50 Economy ticket for $344 per person are available. Travel duration is 8h 15m
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United Airlines9h 4m05:50 PMSan Diego AirportSan Diego Airport4:54 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/7/2025 5:50:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/8/2025 4:54:00 AM. 50 Economy ticket for $347 per person are available. Travel duration is 9h 4m
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Alaska Airlines12h 5m05:51 PMSan Diego AirportSan Diego Airport7:56 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Alaska Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/7/2025 5:51:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/8/2025 7:56:00 AM. 50 Economy ticket for $360 per person are available. Travel duration is 12h 5m
Fastest Flights Monday
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American Airlines8h 32m06:15 AMSan Diego AirportSan Diego Airport4:47 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from American Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/8/2025 6:15:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/8/2025 4:47:00 PM. 50 Economy ticket for $338 per person are available. Travel duration is 8h 32m
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United Airlines8h 44m06:15 AMSan Diego AirportSan Diego Airport4:59 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/8/2025 6:15:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/8/2025 4:59:00 PM. 50 Economy ticket for $271 per person are available. Travel duration is 8h 44m
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Alaska Airlines10h 20m06:15 AMSan Diego AirportSan Diego Airport6:35 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Alaska Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/8/2025 6:15:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/8/2025 6:35:00 PM. 50 Economy ticket for $251 per person are available. Travel duration is 10h 20m
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Spirit Airlines12h 58m07:31 PMSan Diego AirportSan Diego Airport10:29 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/8/2025 7:31:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/9/2025 10:29:00 AM. 50 Economy ticket for $167 per person are available. Travel duration is 12h 58m
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Frontier Airlines24h 46m06:25 AMSan Diego AirportSan Diego Airport9:11 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/8/2025 6:25:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/9/2025 9:11:00 AM. 50 Economy ticket for $135 per person are available. Travel duration is 24h 46m
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Greyhound Lines Mexico50h 25m010:30 AMTijuana AirportTijuana Airport12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound Lines Mexico goes from Tijuana Airport, Tijuana Airport (Mexico) at 7/8/2025 10:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/10/2025 12:55:00 PM. 50 Economy ticket for $246 per person are available. Travel duration is 50h 25m
Fastest Flights Tuesday
Fastest Buses Tuesday
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Greyhound Lines Mexico50h 25m010:30 AMTijuana AirportTijuana Airport12:55 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound Lines Mexico goes from Tijuana Airport, Tijuana Airport (Mexico) at 7/9/2025 10:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 7/11/2025 12:55:00 PM. 50 Economy ticket for $233 per person are available. Travel duration is 50h 25m
Fastest Buses Wednesday
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American Airlines8h 32m06:15 AMSan Diego AirportSan Diego Airport4:47 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from American Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/10/2025 6:15:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/10/2025 4:47:00 PM. 50 Economy ticket for $338 per person are available. Travel duration is 8h 32m
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United Airlines8h 44m06:15 AMSan Diego AirportSan Diego Airport4:59 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/10/2025 6:15:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/10/2025 4:59:00 PM. 50 Economy ticket for $347 per person are available. Travel duration is 8h 44m
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Alaska Airlines10h 20m06:15 AMSan Diego AirportSan Diego Airport6:35 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Alaska Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/10/2025 6:15:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/10/2025 6:35:00 PM. 50 Economy ticket for $319 per person are available. Travel duration is 10h 20m
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Frontier Airlines10h 58m06:25 AMSan Diego AirportSan Diego Airport7:23 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/10/2025 6:25:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/10/2025 7:23:00 PM. 50 Economy ticket for $134 per person are available. Travel duration is 10h 58m
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Spirit Airlines14h 2m09:40 PMSan Diego AirportSan Diego Airport1:42 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Spirit Airlines goes from San Diego Airport, San Diego Airport (USA) at 7/10/2025 9:40:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 7/11/2025 1:42:00 PM. 50 Economy ticket for $231 per person are available. Travel duration is 14h 2m
Fastest Flights Thursday
Here you will find all operators and timetables for a
Bus from San Diego to St. Louis, MO
What are the most popular stations in San Diego and St. Louis, MO?
In San Diego, you will usually depart from Santa Fe Depot, San Ysidro Transit Center or Old Town Transit Center, while in St. Louis, MO you will be arriving at Gateway Station, Lindbergh @ Hackberry NB Bus Stop or Skinker Boulevard, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to St. Louis, MO from San Diego? With 5 connections between 2 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between San Diego and St. Louis, MO, you can pay as low as $134 with a Flight from Frontier Airlines.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from American Airlines: you will get to St. Louis, MO in just 6h 38m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting San Diego and St. Louis, MO are United Airlines, American Airlines and Alaska Airlines, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in San Diego and St. Louis, MO is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from San Diego Airport or to Sauget, IL, and look at flights from Tijuana Airport, and landing at St. Louis Lambert Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from San Diego to St. Louis, MO?
The most popular companies between San Diego and St. Louis, MO, are United Airlines, American Airlines and Alaska Airlines. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Greyhound Lines Mexico, FlixBus and Greyhound US
Airlines: United Airlines, American Airlines, Alaska Airlines and 3 more.
All you need to know when you travel from San Diego to St. Louis, MO
Check all information on comfort and services on all modes of transports from San Diego to St. Louis, MO. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from San Diego to St. Louis, MO
How can I reach St. Louis, MO from San Diego?
Every day, there are on average 5 connections between Bus and Flight, with which you can get to St. Louis, MO from San Diego.
How far is St. Louis, MO from San Diego?
The distance between San Diego and St. Louis, MO is 1,560.7 miles.
What is the most ecofriendly mode of transport between San Diego and St. Louis, MO?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 68 kgs of CO2, a train 88 kgs, a car 427 kgs, and a flight 618 kgs.
What is the cheapest mode of transport from San Diego to St. Louis, MO?
You can get to St. Louis, MO with just $134 by taking a Flight from Frontier Airlines.
What is the fastest way to get from San Diego to St. Louis, MO?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to St. Louis, MO in just 6h 38m with a Flight from American Airlines.
More routes to San Diego and to St. Louis, MO
Looking for more options? Here you can see the most popular routes to San Diego and to St. Louis, MO. Simply click on a connection, and you’ll find all the details about the route!