What is the best way to travel from Chicago to San Diego?
Looking for a trip? Compare all the available Flights and Buses for the journey to San Diego from Chicago. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
What is the cheapest way to reach San Diego from Chicago?
You can get to San Diego with just $109 by taking a Bus from FlixBus, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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Frontier Airlines8h 21m09:20 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center3:41 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/19/2026 9:20:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 8/19/2026 3:41:00 PM. 50 Economy ticket for $118 per person are available. Travel duration is 8h 21m
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Alaska Airlines4h 31m06:01 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center8:32 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/19/2026 6:01:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 8/19/2026 8:32:00 AM. 50 Economy ticket for $128 per person are available. Travel duration is 4h 31m
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United Airlines4h 27m07:05 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center9:32 AMSan Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/19/2026 7:05:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 8/19/2026 9:32:00 AM. 50 Economy ticket for $139 per person are available. Travel duration is 4h 27m
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Volaris13h 28m02:53 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center2:21 PMTijuana AirportTijuana Airport0EconomyA Flight from Volaris goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/19/2026 2:53:00 AM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 8/19/2026 2:21:00 PM. 50 Economy ticket for $156 per person are available. Travel duration is 13h 28m
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Viva Aerobus14h 20m012:25 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center12:45 AMTijuana AirportTijuana Airport0EconomyA Flight from Viva Aerobus goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/19/2026 12:25:00 PM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 8/20/2026 12:45:00 AM. 50 Economy ticket for $202 per person are available. Travel duration is 14h 20m
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JetBlue Airways10h 28m011:01 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center7:29 PMSan Diego AirportSan Diego Airport0EconomyA Flight from JetBlue Airways goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/19/2026 11:01:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 8/19/2026 7:29:00 PM. 50 Economy ticket for $245 per person are available. Travel duration is 10h 28m
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Greyhound US55h 55m012:25 PMChicagoDowntown Bus Station6:20 PMSan DiegoSan Ysidro Transit Center0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 8/19/2026 12:25:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 8/21/2026 6:20:00 PM. 50 Economy ticket for $169 per person are available. Travel duration is 55h 55m
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Greyhound US53h 30m012:25 PMChicagoDowntown Bus Station3:55 PMSan DiegoLa Jolla Village0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 8/19/2026 12:25:00 PM to La Jolla Village, San Diego (USA) arriving at 8/21/2026 3:55:00 PM. 50 Economy ticket for $173 per person are available. Travel duration is 53h 30m
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Greyhound US54h 0m012:25 PMChicagoDowntown Bus Station4:25 PMSan DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 8/19/2026 12:25:00 PM to Old Town Transit Center, San Diego (USA) arriving at 8/21/2026 4:25:00 PM. 50 Economy ticket for $173 per person are available. Travel duration is 54h 0m
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FlixBus50h 20m05:15 PMChicagoDowntown Bus Station5:35 PMSan DiegoLa Jolla Village0EconomyA Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 8/19/2026 5:15:00 PM to La Jolla Village, San Diego (USA) arriving at 8/21/2026 5:35:00 PM. 50 Economy ticket for $190 per person are available. Travel duration is 50h 20m
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FlixBus50h 55m05:15 PMChicagoDowntown Bus Station6:10 PMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 8/19/2026 5:15:00 PM to Old Town Transit Center, San Diego (USA) arriving at 8/21/2026 6:10:00 PM. 50 Economy ticket for $190 per person are available. Travel duration is 50h 55m
Cheapest Flights Wednesday
Cheapest Buses Wednesday
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Frontier Airlines8h 21m09:20 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center3:41 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/20/2026 9:20:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 8/20/2026 3:41:00 PM. 50 Economy ticket for $119 per person are available. Travel duration is 8h 21m
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Alaska Airlines4h 31m06:01 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center8:32 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/20/2026 6:01:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 8/20/2026 8:32:00 AM. 50 Economy ticket for $120 per person are available. Travel duration is 4h 31m
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United Airlines4h 27m07:05 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center9:32 AMSan Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/20/2026 7:05:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 8/20/2026 9:32:00 AM. 50 Economy ticket for $129 per person are available. Travel duration is 4h 27m
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Volaris9h 0m01:59 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center8:59 AMTijuana AirportTijuana Airport0EconomyA Flight from Volaris goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/20/2026 1:59:00 AM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 8/20/2026 8:59:00 AM. 50 Economy ticket for $167 per person are available. Travel duration is 9h 0m
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Sun Country Airlines17h 36m05:29 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center9:05 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Sun Country Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/20/2026 5:29:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 8/21/2026 9:05:00 AM. 50 Economy ticket for $199 per person are available. Travel duration is 17h 36m
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JetBlue Airways14h 50m08:20 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center9:10 AMSan Diego AirportSan Diego Airport0EconomyA Flight from JetBlue Airways goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/20/2026 8:20:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 8/21/2026 9:10:00 AM. 50 Economy ticket for $250 per person are available. Travel duration is 14h 50m
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FlixBus55h 20m011:05 AMChicago95th Red Line Station4:25 PMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 8/20/2026 11:05:00 AM to Old Town Transit Center, San Diego (USA) arriving at 8/22/2026 4:25:00 PM. 50 Economy ticket for $141 per person are available. Travel duration is 55h 20m
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FlixBus61h 5m012:40 AMChicago95th Red Line Station11:45 AMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 8/20/2026 12:40:00 AM to Old Town Transit Center, San Diego (USA) arriving at 8/22/2026 11:45:00 AM. 50 Economy ticket for $143 per person are available. Travel duration is 61h 5m
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FlixBus59h 25m012:40 AMChicago95th Red Line Station10:05 AMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 8/20/2026 12:40:00 AM to Old Town Transit Center, San Diego (USA) arriving at 8/22/2026 10:05:00 AM. 50 Economy ticket for $145 per person are available. Travel duration is 59h 25m
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Greyhound US54h 0m012:25 PMChicagoDowntown Bus Station4:25 PMSan DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 8/20/2026 12:25:00 PM to Old Town Transit Center, San Diego (USA) arriving at 8/22/2026 4:25:00 PM. 50 Economy ticket for $149 per person are available. Travel duration is 54h 0m
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Greyhound US53h 30m012:25 PMChicagoDowntown Bus Station3:55 PMSan DiegoLa Jolla Village0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 8/20/2026 12:25:00 PM to La Jolla Village, San Diego (USA) arriving at 8/22/2026 3:55:00 PM. 50 Economy ticket for $153 per person are available. Travel duration is 53h 30m
Cheapest Flights Thursday
Cheapest Buses Thursday
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FlixBus61h 5m012:40 AMChicago95th Red Line Station11:45 AMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 8/21/2026 12:40:00 AM to Old Town Transit Center, San Diego (USA) arriving at 8/23/2026 11:45:00 AM. 50 Economy ticket for $123 per person are available. Travel duration is 61h 5m
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FlixBus55h 20m011:05 AMChicago95th Red Line Station4:25 PMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 8/21/2026 11:05:00 AM to Old Town Transit Center, San Diego (USA) arriving at 8/23/2026 4:25:00 PM. 50 Economy ticket for $123 per person are available. Travel duration is 55h 20m
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FlixBus59h 45m012:40 AMChicago95th Red Line Station10:25 AMSan DiegoSeaport Village0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 8/21/2026 12:40:00 AM to Seaport Village, San Diego (USA) arriving at 8/23/2026 10:25:00 AM. 50 Economy ticket for $125 per person are available. Travel duration is 59h 45m
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Greyhound US54h 0m012:25 PMChicagoDowntown Bus Station4:25 PMSan DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 8/21/2026 12:25:00 PM to Old Town Transit Center, San Diego (USA) arriving at 8/23/2026 4:25:00 PM. 50 Economy ticket for $129 per person are available. Travel duration is 54h 0m
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Greyhound US62h 0m010:15 AMChicagoCanal & Van Buren10:15 PMSan DiegoSeaport Village0EconomyA Bus from Greyhound US goes from Canal & Van Buren, Chicago (USA) at 8/21/2026 10:15:00 AM to Seaport Village, San Diego (USA) arriving at 8/23/2026 10:15:00 PM. 50 Economy ticket for $143 per person are available. Travel duration is 62h 0m
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Frontier Airlines8h 21m09:20 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center3:41 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/21/2026 9:20:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 8/21/2026 3:41:00 PM. 50 Economy ticket for $123 per person are available. Travel duration is 8h 21m
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Alaska Airlines4h 31m06:01 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center8:32 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/21/2026 6:01:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 8/21/2026 8:32:00 AM. 50 Economy ticket for $140 per person are available. Travel duration is 4h 31m
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United Airlines4h 27m07:05 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center9:32 AMSan Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/21/2026 7:05:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 8/21/2026 9:32:00 AM. 50 Economy ticket for $165 per person are available. Travel duration is 4h 27m
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Volaris16h 43m07:35 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center10:18 PMTijuana AirportTijuana Airport0EconomyA Flight from Volaris goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/21/2026 7:35:00 AM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 8/21/2026 10:18:00 PM. 50 Economy ticket for $173 per person are available. Travel duration is 16h 43m
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Viva Aerobus28h 45m04:20 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center7:05 PMTijuana AirportTijuana Airport0EconomyA Flight from Viva Aerobus goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/21/2026 4:20:00 PM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 8/22/2026 7:05:00 PM. 50 Economy ticket for $228 per person are available. Travel duration is 28h 45m
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Frontier Airlines37h 2m09:26 PMChicago Midway AirportChicago Midway Airport8:28 AMTijuana AirportTijuana Airport0EconomyA Flight from Frontier Airlines goes from Chicago Midway Airport, Chicago Midway Airport (USA) at 8/21/2026 9:26:00 PM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 8/23/2026 8:28:00 AM. 50 Economy ticket for $292 per person are available. Travel duration is 37h 2m
Cheapest Buses Friday
Cheapest Flights Friday
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Greyhound US54h 0m012:25 PMChicagoDowntown Bus Station4:25 PMSan DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 8/22/2026 12:25:00 PM to Old Town Transit Center, San Diego (USA) arriving at 8/24/2026 4:25:00 PM. 50 Economy ticket for $127 per person are available. Travel duration is 54h 0m
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FlixBus61h 5m012:40 AMChicago95th Red Line Station11:45 AMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 8/22/2026 12:40:00 AM to Old Town Transit Center, San Diego (USA) arriving at 8/24/2026 11:45:00 AM. 50 Economy ticket for $128 per person are available. Travel duration is 61h 5m
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FlixBus55h 20m011:05 AMChicago95th Red Line Station4:25 PMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 8/22/2026 11:05:00 AM to Old Town Transit Center, San Diego (USA) arriving at 8/24/2026 4:25:00 PM. 50 Economy ticket for $129 per person are available. Travel duration is 55h 20m
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Greyhound US53h 30m012:25 PMChicagoDowntown Bus Station3:55 PMSan DiegoLa Jolla Village0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 8/22/2026 12:25:00 PM to La Jolla Village, San Diego (USA) arriving at 8/24/2026 3:55:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 53h 30m
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Volaris11h 47m02:53 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center12:40 PMTijuana AirportTijuana Airport0EconomyA Flight from Volaris goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/22/2026 2:53:00 AM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 8/22/2026 12:40:00 PM. 50 Economy ticket for $167 per person are available. Travel duration is 11h 47m
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Frontier Airlines29h 5m011:45 AMChicago Midway AirportChicago Midway Airport2:50 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Chicago Midway Airport, Chicago Midway Airport (USA) at 8/22/2026 11:45:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 8/23/2026 2:50:00 PM. 50 Economy ticket for $187 per person are available. Travel duration is 29h 5m
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Frontier Airlines23h 20m011:45 AMChicago Midway AirportChicago Midway Airport9:05 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Chicago Midway Airport, Chicago Midway Airport (USA) at 8/22/2026 11:45:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 8/23/2026 9:05:00 AM. 50 Economy ticket for $197 per person are available. Travel duration is 23h 20m
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Frontier Airlines38h 6m011:45 AMChicago Midway AirportChicago Midway Airport11:51 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Chicago Midway Airport, Chicago Midway Airport (USA) at 8/22/2026 11:45:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 8/23/2026 11:51:00 PM. 50 Economy ticket for $197 per person are available. Travel duration is 38h 6m
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Viva Aerobus21h 35m012:25 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center8:00 AMTijuana AirportTijuana Airport0EconomyA Flight from Viva Aerobus goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/22/2026 12:25:00 PM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 8/23/2026 8:00:00 AM. 50 Economy ticket for $223 per person are available. Travel duration is 21h 35m
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Frontier Airlines37h 31m09:20 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center8:51 AMTijuana AirportTijuana Airport0EconomyA Flight from Frontier Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/22/2026 9:20:00 PM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 8/24/2026 8:51:00 AM. 50 Economy ticket for $304 per person are available. Travel duration is 37h 31m
Cheapest Buses Saturday
Cheapest Flights Saturday
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Greyhound US54h 0m012:25 PMChicagoDowntown Bus Station4:25 PMSan DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 8/23/2026 12:25:00 PM to Old Town Transit Center, San Diego (USA) arriving at 8/25/2026 4:25:00 PM. 50 Economy ticket for $119 per person are available. Travel duration is 54h 0m
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Greyhound US53h 30m012:25 PMChicagoDowntown Bus Station3:55 PMSan DiegoLa Jolla Village0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 8/23/2026 12:25:00 PM to La Jolla Village, San Diego (USA) arriving at 8/25/2026 3:55:00 PM. 50 Economy ticket for $119 per person are available. Travel duration is 53h 30m
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Greyhound US62h 0m010:15 AMChicagoUnion Station10:15 PMSan DiegoSeaport Village0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 8/23/2026 10:15:00 AM to Seaport Village, San Diego (USA) arriving at 8/25/2026 10:15:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 62h 0m
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FlixBus50h 30m05:15 PMChicagoDowntown Bus Station5:45 PMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 8/23/2026 5:15:00 PM to Old Town Transit Center, San Diego (USA) arriving at 8/25/2026 5:45:00 PM. 50 Economy ticket for $142 per person are available. Travel duration is 50h 30m
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FlixBus55h 0m05:15 PMChicagoDowntown Bus Station10:15 PMSan DiegoSeaport Village0EconomyA Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 8/23/2026 5:15:00 PM to Seaport Village, San Diego (USA) arriving at 8/25/2026 10:15:00 PM. 50 Economy ticket for $142 per person are available. Travel duration is 55h 0m
Cheapest Buses Sunday
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FlixBus61h 5m012:40 AMChicago95th Red Line Station11:45 AMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 8/24/2026 12:40:00 AM to Old Town Transit Center, San Diego (USA) arriving at 8/26/2026 11:45:00 AM. 50 Economy ticket for $109 per person are available. Travel duration is 61h 5m
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FlixBus55h 20m011:05 AMChicago95th Red Line Station4:25 PMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 8/24/2026 11:05:00 AM to Old Town Transit Center, San Diego (USA) arriving at 8/26/2026 4:25:00 PM. 50 Economy ticket for $111 per person are available. Travel duration is 55h 20m
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Greyhound US54h 0m012:25 PMChicagoDowntown Bus Station4:25 PMSan DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 8/24/2026 12:25:00 PM to Old Town Transit Center, San Diego (USA) arriving at 8/26/2026 4:25:00 PM. 50 Economy ticket for $120 per person are available. Travel duration is 54h 0m
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Greyhound US54h 25m01:20 PMChicago95th Red Line Station5:45 PMSan DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 8/24/2026 1:20:00 PM to Old Town Transit Center, San Diego (USA) arriving at 8/26/2026 5:45:00 PM. 50 Economy ticket for $122 per person are available. Travel duration is 54h 25m
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Greyhound US57h 30m010:15 AMChicagoCanal & Van Buren5:45 PMSan DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Canal & Van Buren, Chicago (USA) at 8/24/2026 10:15:00 AM to Old Town Transit Center, San Diego (USA) arriving at 8/26/2026 5:45:00 PM. 50 Economy ticket for $122 per person are available. Travel duration is 57h 30m
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Frontier Airlines20h 24m02:41 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center9:05 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/24/2026 2:41:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 8/25/2026 9:05:00 AM. 50 Economy ticket for $111 per person are available. Travel duration is 20h 24m
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Alaska Airlines4h 31m06:01 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center8:32 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/24/2026 6:01:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 8/24/2026 8:32:00 AM. 50 Economy ticket for $119 per person are available. Travel duration is 4h 31m
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United Airlines4h 27m07:05 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center9:32 AMSan Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/24/2026 7:05:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 8/24/2026 9:32:00 AM. 50 Economy ticket for $130 per person are available. Travel duration is 4h 27m
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Volaris13h 28m02:53 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center2:21 PMTijuana AirportTijuana Airport0EconomyA Flight from Volaris goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/24/2026 2:53:00 AM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 8/24/2026 2:21:00 PM. 50 Economy ticket for $152 per person are available. Travel duration is 13h 28m
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Viva Aerobus26h 25m012:25 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center12:50 PMTijuana AirportTijuana Airport0EconomyA Flight from Viva Aerobus goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/24/2026 12:25:00 PM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 8/25/2026 12:50:00 PM. 50 Economy ticket for $163 per person are available. Travel duration is 26h 25m
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JetBlue Airways15h 29m06:00 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center7:29 PMSan Diego AirportSan Diego Airport0EconomyA Flight from JetBlue Airways goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/24/2026 6:00:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 8/24/2026 7:29:00 PM. 50 Economy ticket for $229 per person are available. Travel duration is 15h 29m
Cheapest Buses Monday
Cheapest Flights Monday
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Frontier Airlines11h 10m02:41 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center11:51 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/25/2026 2:41:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 8/25/2026 11:51:00 PM. 50 Economy ticket for $118 per person are available. Travel duration is 11h 10m
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Alaska Airlines4h 31m06:01 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center8:32 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/25/2026 6:01:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 8/25/2026 8:32:00 AM. 50 Economy ticket for $119 per person are available. Travel duration is 4h 31m
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United Airlines4h 27m07:05 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center9:32 AMSan Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/25/2026 7:05:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 8/25/2026 9:32:00 AM. 50 Economy ticket for $130 per person are available. Travel duration is 4h 27m
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JetBlue Airways10h 28m011:01 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center7:29 PMSan Diego AirportSan Diego Airport0EconomyA Flight from JetBlue Airways goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/25/2026 11:01:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 8/25/2026 7:29:00 PM. 50 Economy ticket for $183 per person are available. Travel duration is 10h 28m
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American Airlines10h 54m011:30 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center8:24 PMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/25/2026 11:30:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 8/25/2026 8:24:00 PM. 50 Economy ticket for $361 per person are available. Travel duration is 10h 54m
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United Airlines8h 4m06:00 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center12:04 PMMcClellan-Palomar AirportMcClellan-Palomar Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/25/2026 6:00:00 AM to McClellan-Palomar Airport, McClellan-Palomar Airport (USA) arriving at 8/25/2026 12:04:00 PM. 50 Economy ticket for $436 per person are available. Travel duration is 8h 4m
Cheapest Flights Tuesday
What are the fastest trips from Chicago to San Diego?
You can get to San Diego from Chicago in just 4h 27m with a Flight from United Airlines. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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United Airlines4h 27m07:05 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center9:32 AMSan Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/19/2026 7:05:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 8/19/2026 9:32:00 AM. 50 Economy ticket for $139 per person are available. Travel duration is 4h 27m
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Alaska Airlines4h 31m06:01 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center8:32 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/19/2026 6:01:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 8/19/2026 8:32:00 AM. 50 Economy ticket for $128 per person are available. Travel duration is 4h 31m
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United Airlines8h 4m06:00 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center12:04 PMMcClellan-Palomar AirportMcClellan-Palomar Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/19/2026 6:00:00 AM to McClellan-Palomar Airport, McClellan-Palomar Airport (USA) arriving at 8/19/2026 12:04:00 PM. 50 Economy ticket for $429 per person are available. Travel duration is 8h 4m
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United Airlines8h 10m02:35 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center8:45 PMMcClellan-Palomar AirportMcClellan-Palomar Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/19/2026 2:35:00 PM to McClellan-Palomar Airport, McClellan-Palomar Airport (USA) arriving at 8/19/2026 8:45:00 PM. 50 Economy ticket for $429 per person are available. Travel duration is 8h 10m
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Frontier Airlines8h 21m09:20 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center3:41 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/19/2026 9:20:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 8/19/2026 3:41:00 PM. 50 Economy ticket for $118 per person are available. Travel duration is 8h 21m
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United Airlines9h 54m012:51 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center8:45 PMMcClellan-Palomar AirportMcClellan-Palomar Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/19/2026 12:51:00 PM to McClellan-Palomar Airport, McClellan-Palomar Airport (USA) arriving at 8/19/2026 8:45:00 PM. 50 Economy ticket for $429 per person are available. Travel duration is 9h 54m
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FlixBus50h 20m05:15 PMChicagoDowntown Bus Station5:35 PMSan DiegoLa Jolla Village0EconomyA Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 8/19/2026 5:15:00 PM to La Jolla Village, San Diego (USA) arriving at 8/21/2026 5:35:00 PM. 50 Economy ticket for $190 per person are available. Travel duration is 50h 20m
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FlixBus50h 55m05:15 PMChicagoDowntown Bus Station6:10 PMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 8/19/2026 5:15:00 PM to Old Town Transit Center, San Diego (USA) arriving at 8/21/2026 6:10:00 PM. 50 Economy ticket for $190 per person are available. Travel duration is 50h 55m
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Greyhound US53h 30m012:25 PMChicagoDowntown Bus Station3:55 PMSan DiegoLa Jolla Village0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 8/19/2026 12:25:00 PM to La Jolla Village, San Diego (USA) arriving at 8/21/2026 3:55:00 PM. 50 Economy ticket for $173 per person are available. Travel duration is 53h 30m
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Greyhound US54h 0m012:25 PMChicagoDowntown Bus Station4:25 PMSan DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 8/19/2026 12:25:00 PM to Old Town Transit Center, San Diego (USA) arriving at 8/21/2026 4:25:00 PM. 50 Economy ticket for $173 per person are available. Travel duration is 54h 0m
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Greyhound US55h 55m012:25 PMChicagoDowntown Bus Station6:20 PMSan DiegoSan Ysidro Transit Center0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 8/19/2026 12:25:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 8/21/2026 6:20:00 PM. 50 Economy ticket for $169 per person are available. Travel duration is 55h 55m
Fastest Flights Wednesday
Fastest Buses Wednesday
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United Airlines4h 27m07:05 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center9:32 AMSan Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/20/2026 7:05:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 8/20/2026 9:32:00 AM. 50 Economy ticket for $129 per person are available. Travel duration is 4h 27m
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Alaska Airlines4h 31m06:01 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center8:32 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/20/2026 6:01:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 8/20/2026 8:32:00 AM. 50 Economy ticket for $120 per person are available. Travel duration is 4h 31m
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United Airlines6h 20m08:40 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center1:00 PMMcClellan-Palomar AirportMcClellan-Palomar Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/20/2026 8:40:00 AM to McClellan-Palomar Airport, McClellan-Palomar Airport (USA) arriving at 8/20/2026 1:00:00 PM. 50 Economy ticket for $565 per person are available. Travel duration is 6h 20m
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United Airlines6h 32m04:20 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center8:52 PMMcClellan-Palomar AirportMcClellan-Palomar Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/20/2026 4:20:00 PM to McClellan-Palomar Airport, McClellan-Palomar Airport (USA) arriving at 8/20/2026 8:52:00 PM. 50 Economy ticket for $565 per person are available. Travel duration is 6h 32m
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United Airlines8h 4m06:00 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center12:04 PMMcClellan-Palomar AirportMcClellan-Palomar Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/20/2026 6:00:00 AM to McClellan-Palomar Airport, McClellan-Palomar Airport (USA) arriving at 8/20/2026 12:04:00 PM. 50 Economy ticket for $429 per person are available. Travel duration is 8h 4m
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United Airlines8h 10m02:35 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center8:45 PMMcClellan-Palomar AirportMcClellan-Palomar Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/20/2026 2:35:00 PM to McClellan-Palomar Airport, McClellan-Palomar Airport (USA) arriving at 8/20/2026 8:45:00 PM. 50 Economy ticket for $429 per person are available. Travel duration is 8h 10m
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Greyhound US53h 30m012:25 PMChicagoDowntown Bus Station3:55 PMSan DiegoLa Jolla Village0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 8/20/2026 12:25:00 PM to La Jolla Village, San Diego (USA) arriving at 8/22/2026 3:55:00 PM. 50 Economy ticket for $153 per person are available. Travel duration is 53h 30m
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Greyhound US54h 0m012:25 PMChicagoDowntown Bus Station4:25 PMSan DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 8/20/2026 12:25:00 PM to Old Town Transit Center, San Diego (USA) arriving at 8/22/2026 4:25:00 PM. 50 Economy ticket for $149 per person are available. Travel duration is 54h 0m
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FlixBus55h 20m011:05 AMChicago95th Red Line Station4:25 PMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 8/20/2026 11:05:00 AM to Old Town Transit Center, San Diego (USA) arriving at 8/22/2026 4:25:00 PM. 50 Economy ticket for $141 per person are available. Travel duration is 55h 20m
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FlixBus59h 25m012:40 AMChicago95th Red Line Station10:05 AMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 8/20/2026 12:40:00 AM to Old Town Transit Center, San Diego (USA) arriving at 8/22/2026 10:05:00 AM. 50 Economy ticket for $145 per person are available. Travel duration is 59h 25m
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FlixBus61h 5m012:40 AMChicago95th Red Line Station11:45 AMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 8/20/2026 12:40:00 AM to Old Town Transit Center, San Diego (USA) arriving at 8/22/2026 11:45:00 AM. 50 Economy ticket for $143 per person are available. Travel duration is 61h 5m
Fastest Flights Thursday
Fastest Buses Thursday
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United Airlines4h 27m07:05 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center9:32 AMSan Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/21/2026 7:05:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 8/21/2026 9:32:00 AM. 50 Economy ticket for $165 per person are available. Travel duration is 4h 27m
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Alaska Airlines4h 31m06:01 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center8:32 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/21/2026 6:01:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 8/21/2026 8:32:00 AM. 50 Economy ticket for $140 per person are available. Travel duration is 4h 31m
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United Airlines8h 4m06:00 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center12:04 PMMcClellan-Palomar AirportMcClellan-Palomar Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/21/2026 6:00:00 AM to McClellan-Palomar Airport, McClellan-Palomar Airport (USA) arriving at 8/21/2026 12:04:00 PM. 50 Economy ticket for $429 per person are available. Travel duration is 8h 4m
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United Airlines8h 10m02:35 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center8:45 PMMcClellan-Palomar AirportMcClellan-Palomar Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/21/2026 2:35:00 PM to McClellan-Palomar Airport, McClellan-Palomar Airport (USA) arriving at 8/21/2026 8:45:00 PM. 50 Economy ticket for $430 per person are available. Travel duration is 8h 10m
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Frontier Airlines8h 21m09:20 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center3:41 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/21/2026 9:20:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 8/21/2026 3:41:00 PM. 50 Economy ticket for $123 per person are available. Travel duration is 8h 21m
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American Airlines11h 24m011:30 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center8:54 PMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/21/2026 11:30:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 8/21/2026 8:54:00 PM. 50 Economy ticket for $356 per person are available. Travel duration is 11h 24m
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Greyhound US54h 0m012:25 PMChicagoDowntown Bus Station4:25 PMSan DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 8/21/2026 12:25:00 PM to Old Town Transit Center, San Diego (USA) arriving at 8/23/2026 4:25:00 PM. 50 Economy ticket for $129 per person are available. Travel duration is 54h 0m
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FlixBus55h 20m011:05 AMChicago95th Red Line Station4:25 PMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 8/21/2026 11:05:00 AM to Old Town Transit Center, San Diego (USA) arriving at 8/23/2026 4:25:00 PM. 50 Economy ticket for $123 per person are available. Travel duration is 55h 20m
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FlixBus59h 45m012:40 AMChicago95th Red Line Station10:25 AMSan DiegoSeaport Village0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 8/21/2026 12:40:00 AM to Seaport Village, San Diego (USA) arriving at 8/23/2026 10:25:00 AM. 50 Economy ticket for $125 per person are available. Travel duration is 59h 45m
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FlixBus61h 5m012:40 AMChicago95th Red Line Station11:45 AMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 8/21/2026 12:40:00 AM to Old Town Transit Center, San Diego (USA) arriving at 8/23/2026 11:45:00 AM. 50 Economy ticket for $123 per person are available. Travel duration is 61h 5m
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Greyhound US62h 0m010:15 AMChicagoCanal & Van Buren10:15 PMSan DiegoSeaport Village0EconomyA Bus from Greyhound US goes from Canal & Van Buren, Chicago (USA) at 8/21/2026 10:15:00 AM to Seaport Village, San Diego (USA) arriving at 8/23/2026 10:15:00 PM. 50 Economy ticket for $143 per person are available. Travel duration is 62h 0m
Fastest Flights Friday
Fastest Buses Friday
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United Airlines7h 29m012:51 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center6:20 PMMcClellan-Palomar AirportMcClellan-Palomar Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/22/2026 12:51:00 PM to McClellan-Palomar Airport, McClellan-Palomar Airport (USA) arriving at 8/22/2026 6:20:00 PM. 50 Economy ticket for $434 per person are available. Travel duration is 7h 29m
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United Airlines8h 4m06:00 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center12:04 PMMcClellan-Palomar AirportMcClellan-Palomar Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/22/2026 6:00:00 AM to McClellan-Palomar Airport, McClellan-Palomar Airport (USA) arriving at 8/22/2026 12:04:00 PM. 50 Economy ticket for $434 per person are available. Travel duration is 8h 4m
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United Airlines9h 45m010:35 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center6:20 PMMcClellan-Palomar AirportMcClellan-Palomar Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/22/2026 10:35:00 AM to McClellan-Palomar Airport, McClellan-Palomar Airport (USA) arriving at 8/22/2026 6:20:00 PM. 50 Economy ticket for $434 per person are available. Travel duration is 9h 45m
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United Airlines10h 0m05:00 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center1:00 PMMcClellan-Palomar AirportMcClellan-Palomar Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/22/2026 5:00:00 AM to McClellan-Palomar Airport, McClellan-Palomar Airport (USA) arriving at 8/22/2026 1:00:00 PM. 50 Economy ticket for $448 per person are available. Travel duration is 10h 0m
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Volaris11h 47m02:53 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center12:40 PMTijuana AirportTijuana Airport0EconomyA Flight from Volaris goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/22/2026 2:53:00 AM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 8/22/2026 12:40:00 PM. 50 Economy ticket for $167 per person are available. Travel duration is 11h 47m
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Aeroméxico11h 48m01:55 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center11:43 AMTijuana AirportTijuana Airport0EconomyA Flight from Aeroméxico goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/22/2026 1:55:00 AM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 8/22/2026 11:43:00 AM. 50 Economy ticket for $447 per person are available. Travel duration is 11h 48m
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Greyhound US53h 30m012:25 PMChicagoDowntown Bus Station3:55 PMSan DiegoLa Jolla Village0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 8/22/2026 12:25:00 PM to La Jolla Village, San Diego (USA) arriving at 8/24/2026 3:55:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 53h 30m
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Greyhound US54h 0m012:25 PMChicagoDowntown Bus Station4:25 PMSan DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 8/22/2026 12:25:00 PM to Old Town Transit Center, San Diego (USA) arriving at 8/24/2026 4:25:00 PM. 50 Economy ticket for $127 per person are available. Travel duration is 54h 0m
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FlixBus55h 20m011:05 AMChicago95th Red Line Station4:25 PMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 8/22/2026 11:05:00 AM to Old Town Transit Center, San Diego (USA) arriving at 8/24/2026 4:25:00 PM. 50 Economy ticket for $129 per person are available. Travel duration is 55h 20m
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FlixBus61h 5m012:40 AMChicago95th Red Line Station11:45 AMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 8/22/2026 12:40:00 AM to Old Town Transit Center, San Diego (USA) arriving at 8/24/2026 11:45:00 AM. 50 Economy ticket for $128 per person are available. Travel duration is 61h 5m
Fastest Flights Saturday
Fastest Buses Saturday
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FlixBus50h 30m05:15 PMChicagoDowntown Bus Station5:45 PMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 8/23/2026 5:15:00 PM to Old Town Transit Center, San Diego (USA) arriving at 8/25/2026 5:45:00 PM. 50 Economy ticket for $142 per person are available. Travel duration is 50h 30m
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Greyhound US53h 30m012:25 PMChicagoDowntown Bus Station3:55 PMSan DiegoLa Jolla Village0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 8/23/2026 12:25:00 PM to La Jolla Village, San Diego (USA) arriving at 8/25/2026 3:55:00 PM. 50 Economy ticket for $119 per person are available. Travel duration is 53h 30m
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Greyhound US54h 0m012:25 PMChicagoDowntown Bus Station4:25 PMSan DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 8/23/2026 12:25:00 PM to Old Town Transit Center, San Diego (USA) arriving at 8/25/2026 4:25:00 PM. 50 Economy ticket for $119 per person are available. Travel duration is 54h 0m
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FlixBus55h 0m05:15 PMChicagoDowntown Bus Station10:15 PMSan DiegoSeaport Village0EconomyA Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 8/23/2026 5:15:00 PM to Seaport Village, San Diego (USA) arriving at 8/25/2026 10:15:00 PM. 50 Economy ticket for $142 per person are available. Travel duration is 55h 0m
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Greyhound US62h 0m010:15 AMChicagoUnion Station10:15 PMSan DiegoSeaport Village0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 8/23/2026 10:15:00 AM to Seaport Village, San Diego (USA) arriving at 8/25/2026 10:15:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 62h 0m
Fastest Buses Sunday
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United Airlines4h 27m07:05 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center9:32 AMSan Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/24/2026 7:05:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 8/24/2026 9:32:00 AM. 50 Economy ticket for $130 per person are available. Travel duration is 4h 27m
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Alaska Airlines4h 31m06:01 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center8:32 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/24/2026 6:01:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 8/24/2026 8:32:00 AM. 50 Economy ticket for $119 per person are available. Travel duration is 4h 31m
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American Airlines10h 54m011:30 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center8:24 PMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/24/2026 11:30:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 8/24/2026 8:24:00 PM. 50 Economy ticket for $361 per person are available. Travel duration is 10h 54m
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Aeroméxico11h 50m01:55 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center11:45 AMTijuana AirportTijuana Airport0EconomyA Flight from Aeroméxico goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/24/2026 1:55:00 AM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 8/24/2026 11:45:00 AM. 50 Economy ticket for $427 per person are available. Travel duration is 11h 50m
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Volaris13h 28m02:53 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center2:21 PMTijuana AirportTijuana Airport0EconomyA Flight from Volaris goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/24/2026 2:53:00 AM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 8/24/2026 2:21:00 PM. 50 Economy ticket for $152 per person are available. Travel duration is 13h 28m
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JetBlue Airways15h 29m06:00 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center7:29 PMSan Diego AirportSan Diego Airport0EconomyA Flight from JetBlue Airways goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/24/2026 6:00:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 8/24/2026 7:29:00 PM. 50 Economy ticket for $229 per person are available. Travel duration is 15h 29m
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Greyhound US54h 0m012:25 PMChicagoDowntown Bus Station4:25 PMSan DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 8/24/2026 12:25:00 PM to Old Town Transit Center, San Diego (USA) arriving at 8/26/2026 4:25:00 PM. 50 Economy ticket for $120 per person are available. Travel duration is 54h 0m
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Greyhound US54h 25m01:20 PMChicago95th Red Line Station5:45 PMSan DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 8/24/2026 1:20:00 PM to Old Town Transit Center, San Diego (USA) arriving at 8/26/2026 5:45:00 PM. 50 Economy ticket for $122 per person are available. Travel duration is 54h 25m
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FlixBus55h 20m011:05 AMChicago95th Red Line Station4:25 PMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 8/24/2026 11:05:00 AM to Old Town Transit Center, San Diego (USA) arriving at 8/26/2026 4:25:00 PM. 50 Economy ticket for $111 per person are available. Travel duration is 55h 20m
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Greyhound US57h 30m010:15 AMChicagoCanal & Van Buren5:45 PMSan DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Canal & Van Buren, Chicago (USA) at 8/24/2026 10:15:00 AM to Old Town Transit Center, San Diego (USA) arriving at 8/26/2026 5:45:00 PM. 50 Economy ticket for $122 per person are available. Travel duration is 57h 30m
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FlixBus61h 5m012:40 AMChicago95th Red Line Station11:45 AMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 8/24/2026 12:40:00 AM to Old Town Transit Center, San Diego (USA) arriving at 8/26/2026 11:45:00 AM. 50 Economy ticket for $109 per person are available. Travel duration is 61h 5m
Fastest Flights Monday
Fastest Buses Monday
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United Airlines4h 27m07:05 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center9:32 AMSan Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/25/2026 7:05:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 8/25/2026 9:32:00 AM. 50 Economy ticket for $130 per person are available. Travel duration is 4h 27m
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Alaska Airlines4h 31m06:01 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center8:32 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/25/2026 6:01:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 8/25/2026 8:32:00 AM. 50 Economy ticket for $119 per person are available. Travel duration is 4h 31m
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United Airlines7h 29m012:51 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center6:20 PMMcClellan-Palomar AirportMcClellan-Palomar Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/25/2026 12:51:00 PM to McClellan-Palomar Airport, McClellan-Palomar Airport (USA) arriving at 8/25/2026 6:20:00 PM. 50 Economy ticket for $437 per person are available. Travel duration is 7h 29m
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United Airlines8h 4m06:00 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center12:04 PMMcClellan-Palomar AirportMcClellan-Palomar Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/25/2026 6:00:00 AM to McClellan-Palomar Airport, McClellan-Palomar Airport (USA) arriving at 8/25/2026 12:04:00 PM. 50 Economy ticket for $436 per person are available. Travel duration is 8h 4m
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United Airlines9h 45m010:35 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center6:20 PMMcClellan-Palomar AirportMcClellan-Palomar Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/25/2026 10:35:00 AM to McClellan-Palomar Airport, McClellan-Palomar Airport (USA) arriving at 8/25/2026 6:20:00 PM. 50 Economy ticket for $437 per person are available. Travel duration is 9h 45m
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JetBlue Airways10h 28m011:01 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center7:29 PMSan Diego AirportSan Diego Airport0EconomyA Flight from JetBlue Airways goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 8/25/2026 11:01:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 8/25/2026 7:29:00 PM. 50 Economy ticket for $183 per person are available. Travel duration is 10h 28m
Fastest Flights Tuesday
Here you will find all operators and timetables for a
Bus from Chicago to San Diego
What are the most popular stations in Chicago and San Diego?
In Chicago, you will usually depart from California & 35th Street Bus Stop, Downtown Bus Station or 95th Red Line Station, while in San Diego you will be arriving at San Ysidro Transit Center, Old Town Transit Center or Santa Fe Depot, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to San Diego from Chicago? With 15 connections between 2 Flight and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Chicago and San Diego, you can pay as low as $109 with a Bus from FlixBus.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from United Airlines: you will get to San Diego in just 4h 27m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Chicago and San Diego are United Airlines, Greyhound US and FlixBus, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Chicago and San Diego is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Cicero, IL or to San Diego Airport, and look at flights from Chicago Midway Airport, and landing at Tijuana Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Chicago to San Diego?
The most popular companies between Chicago and San Diego, are United Airlines, Greyhound US and FlixBus. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Greyhound US and FlixBus
Airlines: United Airlines, Frontier Airlines, Alaska Airlines and 8 more.
All you need to know when you travel from Chicago to San Diego
Check all information on comfort and services on all modes of transports from Chicago to San Diego. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Chicago to San Diego
How can I reach San Diego from Chicago?
Every day, there are on average 15 connections between Flight and Bus, with which you can get to San Diego from Chicago.
How far is San Diego from Chicago?
The distance between Chicago and San Diego is 1,730.9 miles.
What is the most ecofriendly mode of transport between Chicago and San Diego?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 75 kgs of CO2, a train 97 kgs, a car 474 kgs, and a flight 685 kgs.
What is the cheapest mode of transport from Chicago to San Diego?
You can get to San Diego with just $109 by taking a Bus from FlixBus.
What is the fastest way to get from Chicago to San Diego?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to San Diego in just 4h 27m with a Flight from United Airlines.
More routes to Chicago and to San Diego
Looking for more options? Here you can see the most popular routes to Chicago and to San Diego. Simply click on a connection, and you’ll find all the details about the route!
