Which bus from Chicago to San Diego is the cheapest?

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Compare all timetables for the bus from Chicago to San Diego

Here is a selection of the cheapest bus trips from the schedule from Chicago to San Diego from various bus operators like Greyhound US or FlixBus for the next days.

today
tomorrow
$311
Sunday
Monday
Tuesday
$261
Wednesday
$300
Thursday

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 63h 10m 11:10 PM Chicago Union Station 12:20 PM San Diego San Ysidro Transit Center  Economy $311
Greyhound US 58h 20m 10:00 AM Chicago Union Station 6:20 PM San Diego San Ysidro Transit Center  Economy $322
FlixBus 51h 50m 4:30 PM Chicago Downtown Bus Station 6:20 PM San Diego San Ysidro Transit Center  Economy $322
Greyhound US 52h 39m 12:01 PM Chicago Downtown Bus Station 2:40 PM San Diego San Ysidro Transit Center  Economy $326
  • Did you know that if you travel from Chicago to San Diego via El Cajon, CA, you can save more than $75? You can find the corresponding connections below.
    • FlixBus
      69h 10m
      0
      11:10 PM
      Chicago
      Union Station
      5:10 PM
      El Cajon, CA
      Bus Stop
      0
      FlixBus
      Economy
      $228
      • Waiting Time 0h 10m
    • FlixBus
      1h 0m
      0
      5:20 PM
      El Cajon, CA
      Bus Stop
      6:20 PM
      San Diego
      San Ysidro Transit Center
      0
      FlixBus
      Economy
      $8
    Travel time is 19h 20m longer, but you will save $75

Cheapest bus trips Tuesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 60h 55m 11:10 PM Chicago Union Station 10:05 AM San Diego Seaport Village  Economy $261
Greyhound US 52h 9m 12:01 PM Chicago Downtown Bus Station 2:10 PM San Diego Old Town Transit Center  Economy $261
Greyhound US 61h 15m 10:50 PM Chicago Downtown Bus Station 10:05 AM San Diego Seaport Village  Economy $261
FlixBus 51h 40m 4:30 PM Chicago Downtown Bus Station 6:10 PM San Diego Old Town Transit Center  Economy $261
FlixBus 51h 5m 4:30 PM Chicago Downtown Bus Station 5:35 PM San Diego La Jolla Village  Economy $261
  • Did you know that if you travel from Chicago to San Diego via El Cajon, CA, you can save more than $27? You can find the corresponding connections below.
    • FlixBus
      68h 35m
      0
      11:10 PM
      Chicago
      Union Station
      5:10 PM
      El Cajon, CA
      Bus Stop
      0
      FlixBus
      Economy
      $225
      • Waiting Time 0h 10m
    • FlixBus
      0h 25m
      0
      5:20 PM
      El Cajon, CA
      Bus Stop
      5:45 PM
      San Diego
      Old Town Transit Center
      0
      FlixBus
      Economy
      $8
    Travel time is 19h 30m longer, but you will save $27

Cheapest bus trips Wednesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 52h 39m 12:01 PM Chicago Downtown Bus Station 2:40 PM San Diego San Ysidro Transit Center  Economy $300
Greyhound US 58h 20m 10:00 AM Chicago Union Station 6:20 PM San Diego San Ysidro Transit Center  Economy $301
Greyhound US 53h 35m 2:45 PM Chicago Downtown Bus Station 6:20 PM San Diego San Ysidro Transit Center  Economy $302
Greyhound US 62h 15m 10:00 AM Chicago Union Station 10:15 PM San Diego Seaport Village  Economy $303
Greyhound US 53h 0m 2:45 PM Chicago Downtown Bus Station 5:45 PM San Diego Old Town Transit Center  Economy $304
  • Did you know that if you travel from Chicago to San Diego via El Cajon, CA, you can save more than $66? You can find the corresponding connections below.
    • FlixBus
      68h 35m
      0
      11:10 PM
      Chicago
      Union Station
      5:10 PM
      El Cajon, CA
      Bus Stop
      0
      FlixBus
      Economy
      $225
      • Waiting Time 0h 10m
    • FlixBus
      0h 25m
      0
      5:20 PM
      El Cajon, CA
      Bus Stop
      5:45 PM
      San Diego
      Old Town Transit Center
      0
      FlixBus
      Economy
      $8
    Travel time is 17h 56m longer, but you will save $66

Best Price Offer: The price for the cheapest bus from Chicago to San Diego is $152 on 2/1/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Chicago and San Diego

See here how frequent the connections between Chicago and San Diego are, during different times and days of the week.
Wednesday is the busiest day, with more than 19 daily buses from Chicago to San Diego. Saturday has instead the fewest connections, with only 4 daily coaches between Chicago and San Diego.
The busiest time of the day is the Afternoon, with 15 buses from Chicago to San Diego, while Morning sees the fewest connections between Chicago and San Diego, with 10 offers.

Facts about the bus from Chicago to San Diego

Compare all providers like Greyhound US and FlixBus that travel 12 times every day by bus from Chicago to San Diego in one click! Book your bus ticket from Chicago to San Diego starting from $152!

Cheapest Bus $152
Fastest Bus 49h 5m
Earliest Bus 10:00 AM
Latest Bus 11:10 PM
Daily Bus Routes 12 Ø
Distance 1,730.9 miles
Bus Companies Greyhound US and FlixBus

Cheapest bus connections from Chicago to San Diego

Every day, 12 buses from 2 bus companies leave Chicago for San Diego: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 02/06/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 02/01
Monday 02/02
Tuesday 02/03
Wednesday 02/04
Thursday 02/05
Friday 02/06
Saturday 02/07
$311
Sunday 02/08
Monday 02/09
Tuesday 02/10
$261
Wednesday 02/11
$303
Thursday 02/12
Friday 02/13
$250
Saturday 02/14
Sunday 02/15
Monday 02/16
Tuesday 02/17
Wednesday 02/18
Thursday 02/19
Friday 02/20
Saturday 02/21
Sunday 02/22
Monday 02/23
Tuesday 02/24
Wednesday 02/25
Thursday 02/26
Friday 02/27
Saturday 02/28

The cheapest time to travel from Chicago to San Diego

See here on which day and which time of the day you can find the cheapest bus ticket from Chicago to San Diego, for the next 30 days.
With a price starting from $261, Tuesday is the cheapest day for a bus from Chicago to San Diego. Saturday instead is the most expensive day with prices starting from $311.
Evening is the cheapest day time for bus tickets from Chicago to San Diego, with $261. Morning is the most expensive time of the day with prices starting from $268.

How to save money travelling from Chicago to San Diego

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Chicago to San Diego in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Chicago to San Diego, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Chicago to San Diego are also emptier.

Beloved bus companies from Chicago to San Diego

These are the most booked bus companies between Chicago to San Diego from our users.

Greyhound US from Chicago to San Diego

Greyhound US

Here you will find the key facts about the Greyhound US bus route Chicago to San Diego:

Cheapest Price $261
Fastest Bus 49h 39m
Earliest Bus 10:00 AM
Last Bus 11:10 PM
Daily Connections 11 Ø
Found on 2/3/2026

All bus stations and stops in Chicago and San Diego

In the map below, you can see where to find all bus stations in Chicago and San Diego.

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Chicago to San Diego? Compare all modes of transports from Chicago to San Diego.

Service and Comfort on the bus from Chicago to San Diego

Want to know which seat classes are available on the buses from Chicago to San Diego? Or which bus companies serve the route Chicago to San Diego? Below you will find answers to your questions.

FAQs about the Chicago to San Diego bus

How much does a Chicago San Diego bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $152 and takes 58h 55m to reach San Diego. Compare offers to save money!

How much could I save by comparing buses from Chicago to San Diego?

This route is offered by 2 companies with a range of ticket prices between $152 and $342. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to San Diego.

On average, how many connections are available from Chicago to San Diego each day?

Every day, the Chicago to San Diego bus route is served by approximately 12 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Chicago to San Diego take?

The fastest bus from Chicago to San Diego is offered by FlixBus and takes 49h 5m. Bus tickets for this connection cost $261. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Chicago to San Diego?

The earliest bus arriving in San Diego from Chicago starts at 10:00 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Chicago to San Diego?

The latest bus trip departing from Chicago for San Diego starts at 11:10 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Chicago San Diego route?

When traveling by bus from Chicago to San Diego, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Chicago and San Diego?

You can check all the direct connections between Chicago and San Diego by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Chicago to San Diego bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Chicago San Diego bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Chicago San Diego bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Chicago to San Diego on your planned travel date.

How does CheckMyBus find the best bus deals from Chicago to San Diego?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 12 daily trips between Chicago and San Diego. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Chicago to San Diego?

Prices and availability for 12 trips between Chicago and San Diego change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Chicago to San Diego

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Chicago and to San Diego

Here’s an overview of the most popular bus routes to Chicago and to San Diego. Simply click on the connection of your choice, and you will find all the details about your bus route!
Bus to Chicago from Barstow, CA Bus to Chicago from Barstow, CA
Salisbury, NC to Chicago bus Salisbury, NC to Chicago bus
Bus to Chicago from Tupelo, MS Bus to Chicago from Tupelo, MS
From Green Bay, WI to Chicago bus From Green Bay, WI to Chicago bus
Bus Boston, MA to San Diego Bus Boston, MA to San Diego
Bus from Las Cruces, NM to San Diego Bus from Las Cruces, NM to San Diego
Lubbock, TX to San Diego bus Lubbock, TX to San Diego bus
Buses from El Paso, TX to San Diego Buses from El Paso, TX to San Diego
Popular Airport Shuttles to Chicago and to San Diego
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