Bus Chicago to San Diego - Compare all Companies

Compare all timetables for the bus from Chicago to San Diego

Here is a selection of the cheapest bus trips from the schedule from Chicago to San Diego from various bus operators like Greyhound US or FlixBus for the next days.

today

tomorrow

Monday

$131

Tuesday

$115

Wednesday

$135

Thursday

Friday

$169

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	55h 5m	11:20 AM	Chicago	Downtown Bus Station	4:25 PM	San Diego	Old Town Transit Center	Economy	$131	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 11/10/2025 11:20:00 AM to Old Town Transit Center, San Diego (USA) arriving at 11/12/2025 4:25:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 55h 5m
Greyhound US	54h 35m	11:20 AM	Chicago	Downtown Bus Station	3:55 PM	San Diego	La Jolla Village	Economy	$132	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 11/10/2025 11:20:00 AM to La Jolla Village, San Diego (USA) arriving at 11/12/2025 3:55:00 PM. 50 Economy ticket for $132 per person are available. Travel duration is 54h 35m
Greyhound US	62h 15m	10:00 AM	Chicago	Union Station	10:15 PM	San Diego	Seaport Village	Economy	$133	A Bus from Greyhound US goes from Union Station, Chicago (USA) at 11/10/2025 10:00:00 AM to Seaport Village, San Diego (USA) arriving at 11/12/2025 10:15:00 PM. 50 Economy ticket for $133 per person are available. Travel duration is 62h 15m
FlixBus	51h 40m	4:30 PM	Chicago	Downtown Bus Station	6:10 PM	San Diego	Old Town Transit Center	Economy	$165	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 11/10/2025 4:30:00 PM to Old Town Transit Center, San Diego (USA) arriving at 11/12/2025 6:10:00 PM. 50 Economy ticket for $165 per person are available. Travel duration is 51h 40m
FlixBus	57h 20m	4:30 PM	Chicago	Downtown Bus Station	11:50 PM	San Diego	Old Town Transit Center	Economy	$165	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 11/10/2025 4:30:00 PM to Old Town Transit Center, San Diego (USA) arriving at 11/12/2025 11:50:00 PM. 50 Economy ticket for $165 per person are available. Travel duration is 57h 20m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	54h 20m	5:10 PM	Chicago	95th Red Line Station	9:30 PM	San Diego	Seaport Village	Economy	$115	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 11/11/2025 5:10:00 PM to Seaport Village, San Diego (USA) arriving at 11/13/2025 9:30:00 PM. 50 Economy ticket for $115 per person are available. Travel duration is 54h 20m
FlixBus	56h 40m	5:10 PM	Chicago	95th Red Line Station	11:50 PM	San Diego	Old Town Transit Center	Economy	$115	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 11/11/2025 5:10:00 PM to Old Town Transit Center, San Diego (USA) arriving at 11/13/2025 11:50:00 PM. 50 Economy ticket for $115 per person are available. Travel duration is 56h 40m
FlixBus	51h 0m	5:10 PM	Chicago	95th Red Line Station	6:10 PM	San Diego	Old Town Transit Center	Economy	$118	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 11/11/2025 5:10:00 PM to Old Town Transit Center, San Diego (USA) arriving at 11/13/2025 6:10:00 PM. 50 Economy ticket for $118 per person are available. Travel duration is 51h 0m
Greyhound US	62h 5m	10:00 PM	Chicago	Union Station	10:05 AM	San Diego	Seaport Village	Economy	$125	A Bus from Greyhound US goes from Union Station, Chicago (USA) at 11/11/2025 10:00:00 PM to Seaport Village, San Diego (USA) arriving at 11/14/2025 10:05:00 AM. 50 Economy ticket for $125 per person are available. Travel duration is 62h 5m
Greyhound US	63h 45m	10:00 PM	Chicago	Union Station	11:45 AM	San Diego	Old Town Transit Center	Economy	$125	A Bus from Greyhound US goes from Union Station, Chicago (USA) at 11/11/2025 10:00:00 PM to Old Town Transit Center, San Diego (USA) arriving at 11/14/2025 11:45:00 AM. 50 Economy ticket for $125 per person are available. Travel duration is 63h 45m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	63h 45m	10:00 PM	Chicago	Canal & Van Buren	11:45 AM	San Diego	Old Town Transit Center	Economy	$135	A Bus from Greyhound US goes from Canal & Van Buren, Chicago (USA) at 11/12/2025 10:00:00 PM to Old Town Transit Center, San Diego (USA) arriving at 11/15/2025 11:45:00 AM. 50 Economy ticket for $135 per person are available. Travel duration is 63h 45m
Greyhound US	62h 5m	10:00 PM	Chicago	Canal & Van Buren	10:05 AM	San Diego	Seaport Village	Economy	$136	A Bus from Greyhound US goes from Canal & Van Buren, Chicago (USA) at 11/12/2025 10:00:00 PM to Seaport Village, San Diego (USA) arriving at 11/15/2025 10:05:00 AM. 50 Economy ticket for $136 per person are available. Travel duration is 62h 5m
Greyhound US	52h 50m	11:20 AM	Chicago	Downtown Bus Station	2:10 PM	San Diego	Old Town Transit Center	Economy	$138	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 11/12/2025 11:20:00 AM to Old Town Transit Center, San Diego (USA) arriving at 11/14/2025 2:10:00 PM. 50 Economy ticket for $138 per person are available. Travel duration is 52h 50m
FlixBus	58h 25m	5:45 AM	Chicago	95th Red Line Station	2:10 PM	San Diego	Old Town Transit Center	Economy	$167	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 11/12/2025 5:45:00 AM to Old Town Transit Center, San Diego (USA) arriving at 11/14/2025 2:10:00 PM. 50 Economy ticket for $167 per person are available. Travel duration is 58h 25m
FlixBus	57h 55m	5:45 AM	Chicago	95th Red Line Station	1:40 PM	San Diego	La Jolla Village	Economy	$170	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 11/12/2025 5:45:00 AM to La Jolla Village, San Diego (USA) arriving at 11/14/2025 1:40:00 PM. 50 Economy ticket for $170 per person are available. Travel duration is 57h 55m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	52h 50m	11:20 AM	Chicago	Downtown Bus Station	2:10 PM	San Diego	Old Town Transit Center	Economy	$169	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 11/14/2025 11:20:00 AM to Old Town Transit Center, San Diego (USA) arriving at 11/16/2025 2:10:00 PM. 50 Economy ticket for $169 per person are available. Travel duration is 52h 50m
Greyhound US	52h 20m	11:20 AM	Chicago	Downtown Bus Station	1:40 PM	San Diego	La Jolla Village	Economy	$170	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 11/14/2025 11:20:00 AM to La Jolla Village, San Diego (USA) arriving at 11/16/2025 1:40:00 PM. 50 Economy ticket for $170 per person are available. Travel duration is 52h 20m
Greyhound US	74h 15m	10:00 PM	Chicago	Union Station	10:15 PM	San Diego	Seaport Village	Economy	$172	A Bus from Greyhound US goes from Union Station, Chicago (USA) at 11/14/2025 10:00:00 PM to Seaport Village, San Diego (USA) arriving at 11/17/2025 10:15:00 PM. 50 Economy ticket for $172 per person are available. Travel duration is 74h 15m
FlixBus	51h 15m	4:30 PM	Chicago	Downtown Bus Station	5:45 PM	San Diego	Old Town Transit Center	Economy	$175	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 11/14/2025 4:30:00 PM to Old Town Transit Center, San Diego (USA) arriving at 11/16/2025 5:45:00 PM. 50 Economy ticket for $175 per person are available. Travel duration is 51h 15m
FlixBus	51h 40m	4:30 PM	Chicago	Downtown Bus Station	6:10 PM	San Diego	Old Town Transit Center	Economy	$179	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 11/14/2025 4:30:00 PM to Old Town Transit Center, San Diego (USA) arriving at 11/16/2025 6:10:00 PM. 50 Economy ticket for $179 per person are available. Travel duration is 51h 40m

Best Price Offer: The price for the cheapest bus from Chicago to San Diego is $115 on 11/11/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between Chicago and San Diego

See here how frequent the connections between Chicago and San Diego are, during different times and days of the week.

Wednesday is the busiest day, with more than 44 daily buses from Chicago to San Diego. Friday has instead the fewest connections, with only 12 daily coaches between Chicago and San Diego.

The busiest time of the day is the Morning, with 39 buses from Chicago to San Diego, while Night sees the fewest connections between Chicago and San Diego, with 7 offers.

Facts about the bus from Chicago to San Diego

Compare all providers like Greyhound US and FlixBus that travel 27 times every day by bus from Chicago to San Diego in one click! Book your bus ticket from Chicago to San Diego starting from $115!

Cheapest Bus	$115
Fastest Bus	49h 0m
Earliest Bus	10:00 AM
Latest Bus	10:30 PM
Daily Bus Routes	27 Ø
Distance	1,730.9 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from Chicago to San Diego

Every day, 27 buses from 2 bus companies leave Chicago for San Diego: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 11/08/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 11/02

Monday 11/03

Tuesday 11/04

Wednesday 11/05

Thursday 11/06

Friday 11/07

Saturday 11/08

$150

Sunday 11/09

Monday 11/10

$188

Tuesday 11/11

$159

Wednesday 11/12

$135

Thursday 11/13

Friday 11/14

$169

Saturday 11/15

Sunday 11/16

$178

Monday 11/17

Tuesday 11/18

Wednesday 11/19

Thursday 11/20

Friday 11/21

Saturday 11/22

Sunday 11/23

Monday 11/24

Tuesday 11/25

Wednesday 11/26

Thursday 11/27

Friday 11/28

Saturday 11/29

The cheapest time to travel from Chicago to San Diego

See here on which day and which time of the day you can find the cheapest bus ticket from Chicago to San Diego, for the next 30 days.

With a price starting from $115, Tuesday is the cheapest day for a bus from Chicago to San Diego. Friday instead is the most expensive day with prices starting from $169.

Afternoon is the cheapest day time for bus tickets from Chicago to San Diego, with $115. Night is the most expensive time of the day with prices starting from $135.

How to save money travelling from Chicago to San Diego

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Chicago to San Diego in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Chicago to San Diego, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Chicago to San Diego are also emptier.

Beloved bus companies from Chicago to San Diego

These are the most booked bus companies between Chicago to San Diego from our users.

Greyhound US from Chicago to San Diego

Here you will find the key facts about the Greyhound US bus route Chicago to San Diego:

Cheapest Price	$125
Fastest Bus	50h 20m
Earliest Bus	10:00 AM
Last Bus	10:30 PM
Daily Connections	22 Ø
Found on	11/6/2025

All bus stations and stops in Chicago and San Diego

In the map below, you can see where to find all bus stations in Chicago and San Diego.

95th Red Line Station

W. 95th St 14

Downtown Bus Station

West Harrison Street 630-670

Union Station

S Canal St 225

Cumberland CTA

N Cumberland Ave 5800

Canal & Van Buren

S Canal St 310-320

Old Town Transit Center

Congress Street 2727

San Ysidro Transit Center

E San Ysidro Blvd 723

Santa Fe Depot

Kettner Blvd 1050

La Jolla Village

Hyatt Regency

Downtown

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Chicago to San Diego? Compare all modes of transports from Chicago to San Diego.

Service and Comfort on the bus from Chicago to San Diego

Want to know which seat classes are available on the buses from Chicago to San Diego? Or which bus companies serve the route Chicago to San Diego? Below you will find answers to your questions.

FAQs about the Chicago to San Diego bus

How much does a Chicago San Diego bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $115 and takes 52h 20m to reach San Diego. Compare offers to save money!

How much could I save by comparing buses from Chicago to San Diego?

This route is offered by 2 companies with a range of ticket prices between $115 and $242. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to San Diego.

On average, how many connections are available from Chicago to San Diego each day?

Every day, the Chicago to San Diego bus route is served by approximately 27 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Chicago to San Diego take?

The fastest bus from Chicago to San Diego is offered by FlixBus and takes 49h 0m. Bus tickets for this connection cost $118. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Chicago to San Diego?

The earliest bus arriving in San Diego from Chicago starts at 10:00 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Chicago to San Diego?

The latest bus trip departing from Chicago for San Diego starts at 10:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Chicago San Diego route?

When traveling by bus from Chicago to San Diego, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Chicago and San Diego?

You can check all the direct connections between Chicago and San Diego by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Chicago to San Diego bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Chicago San Diego bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Chicago San Diego bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Chicago to San Diego on your planned travel date.

Available seat classes which are offered on the bus route Chicago to San Diego

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Chicago and to San Diego

Here’s an overview of the most popular bus routes to Chicago and to San Diego. Simply click on the connection of your choice, and you will find all the details about your bus route!