Which bus from Mexico City to San Diego is the cheapest?

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Compare all timetables for the bus from Mexico City to San Diego

Here is a selection of the cheapest bus trips from the schedule from Mexico City to San Diego from various bus operators like Flix Mexico for the next days.

today
$224
tomorrow
$223
Thursday
$222
Friday
$222
Saturday
$223
Sunday
$220
Monday
$222

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Flix Mexico 68h 10m 10:00 PM Mexico City San Pedro Santa Clara Bus Stop 5:10 PM San Diego San Ysidro Transit Center  Economy $224
Flix Mexico 67h 45m 10:25 PM Mexico City Fórum Buenavista 5:10 PM San Diego San Ysidro Transit Center  Economy $224
Flix Mexico 73h 15m 12:05 PM Mexico City San Pedro Santa Clara Bus Stop 12:20 PM San Diego San Ysidro Transit Center  Economy $249
Flix Mexico 72h 50m 12:30 PM Mexico City Fórum Buenavista 12:20 PM San Diego San Ysidro Transit Center  Economy $249
  • Did you know that if you travel from Mexico City to San Diego via Tijuana, BC, you can save more than $95? You can find the corresponding connections below.
    • ACN Autobuses
      56h 5m
      0
      10:30 PM
      Mexico City
      Instituto Politécnico Nacional Bus Stop
      4:33 PM
      Tijuana, BC
      Centro Bus Stop
      0
      ACN Autobuses
      Economy
      $125
      • Waiting Time 11h 47m
    • Greyhound US
      1h 15m
      0
      4:20 AM
      Tijuana, BC
      Central Bus Station
      5:35 AM
      San Diego
      San Ysidro Transit Center
      0
      Greyhound US
      Economy
      $5
    Travel Time is 10h 40m shorter, and you will save $95

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Flix Mexico 67h 10m 11:00 PM Mexico City San Pedro Santa Clara Bus Stop 5:10 PM San Diego San Ysidro Transit Center  Economy $223
Flix Mexico 66h 45m 11:25 PM Mexico City Fórum Buenavista 5:10 PM San Diego San Ysidro Transit Center  Economy $223
Flix Mexico 74h 45m 10:35 AM Mexico City San Pedro Santa Clara Bus Stop 12:20 PM San Diego San Ysidro Transit Center  Economy $234
Flix Mexico 74h 20m 11:00 AM Mexico City Fórum Buenavista 12:20 PM San Diego San Ysidro Transit Center  Economy $234
  • Did you know that if you travel from Mexico City to San Diego via Tijuana, BC, you can save more than $94? You can find the corresponding connections below.
    • ACN Autobuses
      56h 5m
      0
      10:30 PM
      Mexico City
      Instituto Politécnico Nacional Bus Stop
      4:33 PM
      Tijuana, BC
      Centro Bus Stop
      0
      ACN Autobuses
      Economy
      $125
      • Waiting Time 11h 47m
    • Greyhound US
      1h 15m
      0
      4:20 AM
      Tijuana, BC
      Central Bus Station
      5:35 AM
      San Diego
      San Ysidro Transit Center
      0
      Greyhound US
      Economy
      $5
    Travel Time is 9h 40m shorter, and you will save $94

Cheapest bus trips Thursday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Flix Mexico 70h 40m 2:40 PM Mexico City San Pedro Santa Clara Bus Stop 12:20 PM San Diego San Ysidro Transit Center  Economy $222
Flix Mexico 70h 15m 3:05 PM Mexico City Fórum Buenavista 12:20 PM San Diego San Ysidro Transit Center  Economy $222
Flix Mexico 67h 10m 11:00 PM Mexico City San Pedro Santa Clara Bus Stop 5:10 PM San Diego San Ysidro Transit Center  Economy $253
Flix Mexico 66h 45m 11:25 PM Mexico City Fórum Buenavista 5:10 PM San Diego San Ysidro Transit Center  Economy $253
  • Did you know that if you travel from Mexico City to San Diego via Tijuana, BC, you can save more than $94? You can find the corresponding connections below.
    • ACN Autobuses
      45h 5m
      0
      10:30 PM
      Mexico City
      Instituto Politécnico Nacional Bus Stop
      4:33 PM
      Tijuana, BC
      Centro Bus Stop
      0
      ACN Autobuses
      Economy
      $123
      • Waiting Time 0h 27m
    • Greyhound US
      1h 35m
      0
      5:00 PM
      Tijuana, BC
      Central Bus Station
      6:35 PM
      San Diego
      San Ysidro Transit Center
      0
      Greyhound US
      Economy
      $5
    Travel Time is 20h 40m shorter, and you will save $94

Cheapest bus trips Friday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Flix Mexico 70h 5m 2:40 PM Mexico City San Pedro Santa Clara Bus Stop 11:45 AM San Diego Old Town Transit Center  Economy $222
Flix Mexico 69h 40m 3:05 PM Mexico City Fórum Buenavista 11:45 AM San Diego Old Town Transit Center  Economy $222
Flix Mexico 67h 55m 10:50 PM Mexico City San Pedro Santa Clara Bus Stop 5:45 PM San Diego Old Town Transit Center  Economy $228
Flix Mexico 67h 15m 11:30 PM Mexico City Fórum Buenavista 5:45 PM San Diego Old Town Transit Center  Economy $228
Flix Mexico 72h 25m 10:50 PM Mexico City San Pedro Santa Clara Bus Stop 10:15 PM San Diego Seaport Village  Economy $228
  • Did you know that if you travel from Mexico City to San Diego via Tijuana, BC, you can save more than $94? You can find the corresponding connections below.
    • ACN Autobuses
      45h 5m
      0
      10:30 PM
      Mexico City
      Instituto Politécnico Nacional Bus Stop
      4:33 PM
      Tijuana, BC
      Centro Bus Stop
      0
      ACN Autobuses
      Economy
      $123
      • Waiting Time 0h 27m
    • Greyhound US
      1h 35m
      0
      5:00 PM
      Tijuana, BC
      Central Bus Station
      6:35 PM
      San Diego
      San Ysidro Transit Center
      0
      Greyhound US
      Economy
      $5
    Travel Time is 21h 10m shorter, and you will save $94

Cheapest bus trips Saturday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Flix Mexico 65h 55m 11:30 PM Mexico City Fórum Buenavista 4:25 PM San Diego Old Town Transit Center  Economy $223
Flix Mexico 71h 45m 11:30 PM Mexico City Fórum Buenavista 10:15 PM San Diego Seaport Village  Economy $226
Flix Mexico 69h 40m 3:05 PM Mexico City Fórum Buenavista 11:45 AM San Diego Old Town Transit Center  Economy $228
Flix Mexico 67h 15m 11:30 PM Mexico City Fórum Buenavista 5:45 PM San Diego Old Town Transit Center  Economy $228
Flix Mexico 70h 15m 3:05 PM Mexico City Fórum Buenavista 12:20 PM San Diego San Ysidro Transit Center  Economy $235
  • Did you know that if you travel from Mexico City to San Diego via Tijuana, BC, you can save more than $95? You can find the corresponding connections below.
    • ACN Autobuses
      45h 5m
      0
      10:30 PM
      Mexico City
      Instituto Politécnico Nacional Bus Stop
      4:33 PM
      Tijuana, BC
      Centro Bus Stop
      0
      ACN Autobuses
      Economy
      $123
      • Waiting Time 0h 27m
    • Greyhound US
      1h 35m
      0
      5:00 PM
      Tijuana, BC
      Central Bus Station
      6:35 PM
      San Diego
      San Ysidro Transit Center
      0
      Greyhound US
      Economy
      $5
    Travel Time is 19h 50m shorter, and you will save $95

Cheapest bus trips Sunday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Flix Mexico 66h 35m 10:50 PM Mexico City San Pedro Santa Clara Bus Stop 4:25 PM San Diego Old Town Transit Center  Economy $220
Flix Mexico 74h 0m 10:50 PM Mexico City San Pedro Santa Clara Bus Stop 11:50 PM San Diego Old Town Transit Center  Economy $220
Flix Mexico 65h 55m 11:30 PM Mexico City Fórum Buenavista 4:25 PM San Diego Old Town Transit Center  Economy $220
Flix Mexico 73h 20m 11:30 PM Mexico City Fórum Buenavista 11:50 PM San Diego Old Town Transit Center  Economy $220
Flix Mexico 72h 25m 10:50 PM Mexico City San Pedro Santa Clara Bus Stop 10:15 PM San Diego Seaport Village  Economy $220
  • Did you know that if you travel from Mexico City to San Diego via Tijuana, BC, you can save more than $92? You can find the corresponding connections below.
    • ACN Autobuses
      45h 5m
      0
      10:30 PM
      Mexico City
      Instituto Politécnico Nacional Bus Stop
      4:33 PM
      Tijuana, BC
      Centro Bus Stop
      0
      ACN Autobuses
      Economy
      $123
      • Waiting Time 0h 27m
    • Greyhound US
      1h 35m
      0
      5:00 PM
      Tijuana, BC
      Central Bus Station
      6:35 PM
      San Diego
      San Ysidro Transit Center
      0
      Greyhound US
      Economy
      $5
    Travel Time is 19h 50m shorter, and you will save $92

Cheapest bus trips Monday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Flix Mexico 66h 0m 11:25 PM Mexico City San Pedro Santa Clara Bus Stop 4:25 PM San Diego Old Town Transit Center  Economy $222
Flix Mexico 65h 35m 11:50 PM Mexico City Fórum Buenavista 4:25 PM San Diego Old Town Transit Center  Economy $222
Flix Mexico 66h 45m 11:25 PM Mexico City San Pedro Santa Clara Bus Stop 5:10 PM San Diego San Ysidro Transit Center  Economy $223
Flix Mexico 66h 20m 11:50 PM Mexico City Fórum Buenavista 5:10 PM San Diego San Ysidro Transit Center  Economy $223
Flix Mexico 65h 30m 11:25 PM Mexico City San Pedro Santa Clara Bus Stop 3:55 PM San Diego La Jolla Village  Economy $224
  • Did you know that if you travel from Mexico City to San Diego via Tijuana, BC, you can save more than $94? You can find the corresponding connections below.
    • ACN Autobuses
      45h 5m
      0
      10:30 PM
      Mexico City
      Instituto Politécnico Nacional Bus Stop
      4:33 PM
      Tijuana, BC
      Centro Bus Stop
      0
      ACN Autobuses
      Economy
      $123
      • Waiting Time 0h 27m
    • Greyhound US
      1h 35m
      0
      5:00 PM
      Tijuana, BC
      Central Bus Station
      6:35 PM
      San Diego
      San Ysidro Transit Center
      0
      Greyhound US
      Economy
      $5
    Travel Time is 19h 25m shorter, and you will save $94

Best Price Offer: The price for the cheapest bus from Mexico City to San Diego is $220 on 5/10/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Mexico City and San Diego

See here how frequent the connections between Mexico City and San Diego are, during different times and days of the week.
Monday is the busiest day, with more than 22 daily buses from Mexico City to San Diego. Tuesday has instead the fewest connections, with only 4 daily coaches between Mexico City and San Diego.
The busiest time of the day is the Evening, with 48 buses from Mexico City to San Diego, while Morning sees the fewest connections between Mexico City and San Diego, with 2 offers.

Facts about the bus from Mexico City to San Diego

Compare all providers like Flix Mexico that travel 10 times every day by bus from Mexico City to San Diego in one click! Book your bus ticket from Mexico City to San Diego starting from $220!

Cheapest Bus $220
Fastest Bus 64h 5m
Earliest Bus 12:05 PM
Latest Bus 11:50 PM
Daily Bus Routes 10 Ø
Distance 1,443.3 miles
Bus Companies Flix Mexico

Cheapest bus connections from Mexico City to San Diego

Every day, 10 buses from 1 bus companies leave Mexico City for San Diego: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 05/05/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 05/03
Monday 05/04
Tuesday 05/05
$224
Wednesday 05/06
$223
Thursday 05/07
$222
Friday 05/08
$222
Saturday 05/09
$235
Sunday 05/10
$236
Monday 05/11
$223
Tuesday 05/12
$222
Wednesday 05/13
$224
Thursday 05/14
$234
Friday 05/15
$224
Saturday 05/16
$222
Sunday 05/17
$220
Monday 05/18
$222
Tuesday 05/19
$221
Wednesday 05/20
$222
Thursday 05/21
$225
Friday 05/22
$223
Saturday 05/23
$222
Sunday 05/24
$223
Monday 05/25
$221
Tuesday 05/26
$221
Wednesday 05/27
$223
Thursday 05/28
$224
Friday 05/29
$222
Saturday 05/30

The cheapest time to travel from Mexico City to San Diego

See here on which day and which time of the day you can find the cheapest bus ticket from Mexico City to San Diego, for the next 30 days.
With a price starting from $220, Saturday is the cheapest day for a bus from Mexico City to San Diego. Thursday instead is the most expensive day with prices starting from $222.
Evening is the cheapest day time for bus tickets from Mexico City to San Diego, with $220. Morning is the most expensive time of the day with prices starting from $232.

How to save money travelling from Mexico City to San Diego

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Mexico City to San Diego in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Mexico City to San Diego, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Mexico City to San Diego are also emptier.

All bus stations and stops in Mexico City and San Diego

In the map below, you can see where to find all bus stations in Mexico City and San Diego.

Service and Comfort on the bus from Mexico City to San Diego

Want to know which seat classes are available on the buses from Mexico City to San Diego? Or which bus companies serve the route Mexico City to San Diego? Below you will find answers to your questions.

FAQs about the Mexico City to San Diego bus

How much does a Mexico City San Diego bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $220 and takes 73h 0m to reach San Diego. Compare offers to save money!

How much could I save by comparing buses from Mexico City to San Diego?

This route is offered by 1 companies with a range of ticket prices between $220 and $253. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to San Diego.

On average, how many connections are available from Mexico City to San Diego each day?

Every day, the Mexico City to San Diego bus route is served by approximately 10 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Mexico City to San Diego take?

The fastest bus from Mexico City to San Diego is offered by Flix Mexico and takes 64h 5m. Bus tickets for this connection cost $224. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Mexico City to San Diego?

The earliest bus arriving in San Diego from Mexico City starts at 12:05 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Mexico City to San Diego?

The latest bus trip departing from Mexico City for San Diego starts at 11:50 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Mexico City San Diego route?

When traveling by bus from Mexico City to San Diego, passengers can travel with Flix Mexico. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Mexico City and San Diego?

You can check all the direct connections between Mexico City and San Diego by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Flix Mexico.

What can I take with me on the Mexico City to San Diego bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Mexico City San Diego bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Mexico City San Diego bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Mexico City to San Diego on your planned travel date.

How does CheckMyBus find the best bus deals from Mexico City to San Diego?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 10 daily trips between Mexico City and San Diego. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Mexico City to San Diego?

Prices and availability for 10 trips between Mexico City and San Diego change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Mexico City to San Diego

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Mexico City and to San Diego

Here’s an overview of the most popular bus routes to Mexico City and to San Diego. Simply click on the connection of your choice, and you will find all the details about your bus route!
From Tonalá to Mexico City bus From Tonalá to Mexico City bus
Bus Ramos Arizpe - Mexico City Bus Ramos Arizpe - Mexico City
Buses to Mexico City from Nueva Rosita, CO Buses to Mexico City from Nueva Rosita, CO
Bus to Mexico City from San Cristóbal de las Casas Bus to Mexico City from San Cristóbal de las Casas
Bus from Philadelphia to San Diego Bus from Philadelphia to San Diego
Bus to San Diego from Blythe, CA Bus to San Diego from Blythe, CA
Buses to San Diego from Redding, CA Buses to San Diego from Redding, CA
Stockton, CA to San Diego bus Stockton, CA to San Diego bus
Popular Airport Shuttles to Mexico City and to San Diego
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