Bus Mexico City to San Diego - Compare all Companies

Compare all timetables for the bus from Mexico City to San Diego

Here is a selection of the cheapest bus trips from the schedule from Mexico City to San Diego from various bus operators like Flix Mexico for the next days.

today

$219

tomorrow

$220

Monday

$219

Tuesday

$217

Wednesday

$222

Thursday

$220

Friday

$220

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Flix Mexico	69h 40m	3:05 PM	Mexico City	Fórum Buenavista	11:45 AM	San Diego	Old Town Transit Center	Economy	$219	A Bus from Flix Mexico goes from Fórum Buenavista, Mexico City (Mexico) at 6/20/2026 3:05:00 PM to Old Town Transit Center, San Diego (USA) arriving at 6/23/2026 11:45:00 AM. 50 Economy ticket for $219 per person are available. Travel duration is 69h 40m
Flix Mexico	68h 0m	10:45 PM	Mexico City	Fórum Buenavista	5:45 PM	San Diego	Old Town Transit Center	Economy	$255	A Bus from Flix Mexico goes from Fórum Buenavista, Mexico City (Mexico) at 6/20/2026 10:45:00 PM to Old Town Transit Center, San Diego (USA) arriving at 6/23/2026 5:45:00 PM. 50 Economy ticket for $255 per person are available. Travel duration is 68h 0m
Flix Mexico	72h 30m	10:45 PM	Mexico City	Fórum Buenavista	10:15 PM	San Diego	Seaport Village	Economy	$258	A Bus from Flix Mexico goes from Fórum Buenavista, Mexico City (Mexico) at 6/20/2026 10:45:00 PM to Seaport Village, San Diego (USA) arriving at 6/23/2026 10:15:00 PM. 50 Economy ticket for $258 per person are available. Travel duration is 72h 30m
Flix Mexico	66h 40m	10:45 PM	Mexico City	Fórum Buenavista	4:25 PM	San Diego	Old Town Transit Center	Economy	$259	A Bus from Flix Mexico goes from Fórum Buenavista, Mexico City (Mexico) at 6/20/2026 10:45:00 PM to Old Town Transit Center, San Diego (USA) arriving at 6/23/2026 4:25:00 PM. 50 Economy ticket for $259 per person are available. Travel duration is 66h 40m
Flix Mexico	67h 25m	10:45 PM	Mexico City	Fórum Buenavista	5:10 PM	San Diego	San Ysidro Transit Center	Economy	$314	A Bus from Flix Mexico goes from Fórum Buenavista, Mexico City (Mexico) at 6/20/2026 10:45:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 6/23/2026 5:10:00 PM. 50 Economy ticket for $314 per person are available. Travel duration is 67h 25m

Did you know that if you travel from Mexico City to San Diego via Tijuana, BC, you can save more than $90? You can find the corresponding connections below.
- ACN Autobuses
  
  55h 35m
  
  0
  
  10:00 PM
  
  Mexico City
  Calz. Ignacio Zaragoza
  
  4:33 PM
  
  Tijuana, BC
  Centro Bus Stop
  
  0
  
  Economy
  
  $124
  
  A Bus from ACN Autobuses goes from Calz. Ignacio Zaragoza, Mexico City (Mexico) at 6/21/2026 10:00:00 PM to Centro Bus Stop, Tijuana, BC (Mexico) arriving at 6/23/2026 4:33:00 PM. 50 Economy ticket for $124 per person are available. Travel duration is 43h 33m
- Greyhound US
  
  1h 15m
  
  0
  
  3:20 AM
  
  Tijuana, BC
  Central Bus Station
  
  4:35 AM
  
  San Diego
  San Ysidro Transit Center
  
  0
  
  Economy
  
  $5
  
  A Bus from Greyhound US goes from Central Bus Station, Tijuana, BC (Mexico) at 6/24/2026 3:20:00 AM to San Ysidro Transit Center, San Diego (USA) arriving at 6/24/2026 4:35:00 AM. 50 Economy ticket for $5 per person are available. Travel duration is 1h 15m
Travel Time is 10h 5m shorter, and you will save $90

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Flix Mexico	70h 5m	2:40 PM	Mexico City	San Pedro Santa Clara Bus Stop	11:45 AM	San Diego	Old Town Transit Center	Economy	$220	A Bus from Flix Mexico goes from San Pedro Santa Clara Bus Stop, Mexico City (Mexico) at 6/21/2026 2:40:00 PM to Old Town Transit Center, San Diego (USA) arriving at 6/24/2026 11:45:00 AM. 50 Economy ticket for $220 per person are available. Travel duration is 70h 5m
Flix Mexico	69h 40m	3:05 PM	Mexico City	Fórum Buenavista	11:45 AM	San Diego	Old Town Transit Center	Economy	$220	A Bus from Flix Mexico goes from Fórum Buenavista, Mexico City (Mexico) at 6/21/2026 3:05:00 PM to Old Town Transit Center, San Diego (USA) arriving at 6/24/2026 11:45:00 AM. 50 Economy ticket for $220 per person are available. Travel duration is 69h 40m
Flix Mexico	70h 40m	2:40 PM	Mexico City	San Pedro Santa Clara Bus Stop	12:20 PM	San Diego	San Ysidro Transit Center	Economy	$223	A Bus from Flix Mexico goes from San Pedro Santa Clara Bus Stop, Mexico City (Mexico) at 6/21/2026 2:40:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 6/24/2026 12:20:00 PM. 50 Economy ticket for $223 per person are available. Travel duration is 70h 40m
Flix Mexico	70h 15m	3:05 PM	Mexico City	Fórum Buenavista	12:20 PM	San Diego	San Ysidro Transit Center	Economy	$223	A Bus from Flix Mexico goes from Fórum Buenavista, Mexico City (Mexico) at 6/21/2026 3:05:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 6/24/2026 12:20:00 PM. 50 Economy ticket for $223 per person are available. Travel duration is 70h 15m
Flix Mexico	67h 50m	10:20 PM	Mexico City	San Pedro Santa Clara Bus Stop	5:10 PM	San Diego	San Ysidro Transit Center	Economy	$225	A Bus from Flix Mexico goes from San Pedro Santa Clara Bus Stop, Mexico City (Mexico) at 6/21/2026 10:20:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 6/24/2026 5:10:00 PM. 50 Economy ticket for $225 per person are available. Travel duration is 67h 50m

Did you know that if you travel from Mexico City to San Diego via Tijuana, BC, you can save more than $91? You can find the corresponding connections below.
- ACN Autobuses
  
  45h 35m
  
  0
  
  10:00 PM
  
  Mexico City
  Calz. Ignacio Zaragoza
  
  4:33 PM
  
  Tijuana, BC
  Centro Bus Stop
  
  0
  
  Economy
  
  $124
  
  A Bus from ACN Autobuses goes from Calz. Ignacio Zaragoza, Mexico City (Mexico) at 6/23/2026 10:00:00 PM to Centro Bus Stop, Tijuana, BC (Mexico) arriving at 6/25/2026 4:33:00 PM. 50 Economy ticket for $124 per person are available. Travel duration is 43h 33m
- Greyhound US
  
  1h 35m
  
  0
  
  5:00 PM
  
  Tijuana, BC
  Central Bus Station
  
  6:35 PM
  
  San Diego
  San Ysidro Transit Center
  
  0
  
  Economy
  
  $5
  
  A Bus from Greyhound US goes from Central Bus Station, Tijuana, BC (Mexico) at 6/25/2026 5:00:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 6/25/2026 6:35:00 PM. 50 Economy ticket for $5 per person are available. Travel duration is 1h 35m
Travel Time is 21h 15m shorter, and you will save $91

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Flix Mexico	70h 5m	2:40 PM	Mexico City	San Pedro Santa Clara Bus Stop	11:45 AM	San Diego	Old Town Transit Center	Economy	$219	A Bus from Flix Mexico goes from San Pedro Santa Clara Bus Stop, Mexico City (Mexico) at 6/22/2026 2:40:00 PM to Old Town Transit Center, San Diego (USA) arriving at 6/25/2026 11:45:00 AM. 50 Economy ticket for $219 per person are available. Travel duration is 70h 5m
Flix Mexico	68h 25m	10:20 PM	Mexico City	San Pedro Santa Clara Bus Stop	5:45 PM	San Diego	Old Town Transit Center	Economy	$219	A Bus from Flix Mexico goes from San Pedro Santa Clara Bus Stop, Mexico City (Mexico) at 6/22/2026 10:20:00 PM to Old Town Transit Center, San Diego (USA) arriving at 6/25/2026 5:45:00 PM. 50 Economy ticket for $219 per person are available. Travel duration is 68h 25m
Flix Mexico	69h 40m	3:05 PM	Mexico City	Fórum Buenavista	11:45 AM	San Diego	Old Town Transit Center	Economy	$219	A Bus from Flix Mexico goes from Fórum Buenavista, Mexico City (Mexico) at 6/22/2026 3:05:00 PM to Old Town Transit Center, San Diego (USA) arriving at 6/25/2026 11:45:00 AM. 50 Economy ticket for $219 per person are available. Travel duration is 69h 40m
Flix Mexico	68h 0m	10:45 PM	Mexico City	Fórum Buenavista	5:45 PM	San Diego	Old Town Transit Center	Economy	$219	A Bus from Flix Mexico goes from Fórum Buenavista, Mexico City (Mexico) at 6/22/2026 10:45:00 PM to Old Town Transit Center, San Diego (USA) arriving at 6/25/2026 5:45:00 PM. 50 Economy ticket for $219 per person are available. Travel duration is 68h 0m
Flix Mexico	72h 55m	10:20 PM	Mexico City	San Pedro Santa Clara Bus Stop	10:15 PM	San Diego	Seaport Village	Economy	$219	A Bus from Flix Mexico goes from San Pedro Santa Clara Bus Stop, Mexico City (Mexico) at 6/22/2026 10:20:00 PM to Seaport Village, San Diego (USA) arriving at 6/25/2026 10:15:00 PM. 50 Economy ticket for $219 per person are available. Travel duration is 72h 55m

Did you know that if you travel from Mexico City to San Diego via Tijuana, BC, you can save more than $90? You can find the corresponding connections below.
- ACN Autobuses
  
  45h 35m
  
  0
  
  10:00 PM
  
  Mexico City
  Calz. Ignacio Zaragoza
  
  4:33 PM
  
  Tijuana, BC
  Centro Bus Stop
  
  0
  
  Economy
  
  $124
  
  A Bus from ACN Autobuses goes from Calz. Ignacio Zaragoza, Mexico City (Mexico) at 6/23/2026 10:00:00 PM to Centro Bus Stop, Tijuana, BC (Mexico) arriving at 6/25/2026 4:33:00 PM. 50 Economy ticket for $124 per person are available. Travel duration is 43h 33m
- Greyhound US
  
  1h 35m
  
  0
  
  5:00 PM
  
  Tijuana, BC
  Central Bus Station
  
  6:35 PM
  
  San Diego
  San Ysidro Transit Center
  
  0
  
  Economy
  
  $5
  
  A Bus from Greyhound US goes from Central Bus Station, Tijuana, BC (Mexico) at 6/25/2026 5:00:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 6/25/2026 6:35:00 PM. 50 Economy ticket for $5 per person are available. Travel duration is 1h 35m
Travel Time is 21h 25m shorter, and you will save $90

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Flix Mexico	73h 10m	11:35 AM	Mexico City	San Pedro Santa Clara Bus Stop	11:45 AM	San Diego	Old Town Transit Center	Economy	$217	A Bus from Flix Mexico goes from San Pedro Santa Clara Bus Stop, Mexico City (Mexico) at 6/23/2026 11:35:00 AM to Old Town Transit Center, San Diego (USA) arriving at 6/26/2026 11:45:00 AM. 50 Economy ticket for $217 per person are available. Travel duration is 73h 10m
Flix Mexico	72h 45m	12:00 PM	Mexico City	Fórum Buenavista	11:45 AM	San Diego	Old Town Transit Center	Economy	$217	A Bus from Flix Mexico goes from Fórum Buenavista, Mexico City (Mexico) at 6/23/2026 12:00:00 PM to Old Town Transit Center, San Diego (USA) arriving at 6/26/2026 11:45:00 AM. 50 Economy ticket for $217 per person are available. Travel duration is 72h 45m
Flix Mexico	68h 45m	10:00 PM	Mexico City	San Pedro Santa Clara Bus Stop	5:45 PM	San Diego	Old Town Transit Center	Economy	$221	A Bus from Flix Mexico goes from San Pedro Santa Clara Bus Stop, Mexico City (Mexico) at 6/23/2026 10:00:00 PM to Old Town Transit Center, San Diego (USA) arriving at 6/26/2026 5:45:00 PM. 50 Economy ticket for $221 per person are available. Travel duration is 68h 45m
Flix Mexico	68h 20m	10:25 PM	Mexico City	Fórum Buenavista	5:45 PM	San Diego	Old Town Transit Center	Economy	$221	A Bus from Flix Mexico goes from Fórum Buenavista, Mexico City (Mexico) at 6/23/2026 10:25:00 PM to Old Town Transit Center, San Diego (USA) arriving at 6/26/2026 5:45:00 PM. 50 Economy ticket for $221 per person are available. Travel duration is 68h 20m
Flix Mexico	73h 15m	10:00 PM	Mexico City	San Pedro Santa Clara Bus Stop	10:15 PM	San Diego	Seaport Village	Economy	$221	A Bus from Flix Mexico goes from San Pedro Santa Clara Bus Stop, Mexico City (Mexico) at 6/23/2026 10:00:00 PM to Seaport Village, San Diego (USA) arriving at 6/26/2026 10:15:00 PM. 50 Economy ticket for $221 per person are available. Travel duration is 73h 15m

Did you know that if you travel from Mexico City to San Diego via Tijuana, BC, you can save more than $88? You can find the corresponding connections below.
- ACN Autobuses
  
  45h 35m
  
  0
  
  10:00 PM
  
  Mexico City
  Calz. Ignacio Zaragoza
  
  4:33 PM
  
  Tijuana, BC
  Centro Bus Stop
  
  0
  
  Economy
  
  $124
  
  A Bus from ACN Autobuses goes from Calz. Ignacio Zaragoza, Mexico City (Mexico) at 6/23/2026 10:00:00 PM to Centro Bus Stop, Tijuana, BC (Mexico) arriving at 6/25/2026 4:33:00 PM. 50 Economy ticket for $124 per person are available. Travel duration is 43h 33m
- Greyhound US
  
  1h 35m
  
  0
  
  5:00 PM
  
  Tijuana, BC
  Central Bus Station
  
  6:35 PM
  
  San Diego
  San Ysidro Transit Center
  
  0
  
  Economy
  
  $5
  
  A Bus from Greyhound US goes from Central Bus Station, Tijuana, BC (Mexico) at 6/25/2026 5:00:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 6/25/2026 6:35:00 PM. 50 Economy ticket for $5 per person are available. Travel duration is 1h 35m
Travel Time is 21h 45m shorter, and you will save $88

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Flix Mexico	72h 55m	10:20 PM	Mexico City	San Pedro Santa Clara Bus Stop	10:15 PM	San Diego	Seaport Village	Economy	$222	A Bus from Flix Mexico goes from San Pedro Santa Clara Bus Stop, Mexico City (Mexico) at 6/24/2026 10:20:00 PM to Seaport Village, San Diego (USA) arriving at 6/27/2026 10:15:00 PM. 50 Economy ticket for $222 per person are available. Travel duration is 72h 55m
Flix Mexico	66h 35m	10:20 PM	Mexico City	San Pedro Santa Clara Bus Stop	3:55 PM	San Diego	La Jolla Village	Economy	$222	A Bus from Flix Mexico goes from San Pedro Santa Clara Bus Stop, Mexico City (Mexico) at 6/24/2026 10:20:00 PM to La Jolla Village, San Diego (USA) arriving at 6/27/2026 3:55:00 PM. 50 Economy ticket for $222 per person are available. Travel duration is 66h 35m
Flix Mexico	72h 30m	10:45 PM	Mexico City	Fórum Buenavista	10:15 PM	San Diego	Seaport Village	Economy	$222	A Bus from Flix Mexico goes from Fórum Buenavista, Mexico City (Mexico) at 6/24/2026 10:45:00 PM to Seaport Village, San Diego (USA) arriving at 6/27/2026 10:15:00 PM. 50 Economy ticket for $222 per person are available. Travel duration is 72h 30m
Flix Mexico	66h 10m	10:45 PM	Mexico City	Fórum Buenavista	3:55 PM	San Diego	La Jolla Village	Economy	$222	A Bus from Flix Mexico goes from Fórum Buenavista, Mexico City (Mexico) at 6/24/2026 10:45:00 PM to La Jolla Village, San Diego (USA) arriving at 6/27/2026 3:55:00 PM. 50 Economy ticket for $222 per person are available. Travel duration is 66h 10m
Flix Mexico	68h 25m	10:20 PM	Mexico City	San Pedro Santa Clara Bus Stop	5:45 PM	San Diego	Old Town Transit Center	Economy	$223	A Bus from Flix Mexico goes from San Pedro Santa Clara Bus Stop, Mexico City (Mexico) at 6/24/2026 10:20:00 PM to Old Town Transit Center, San Diego (USA) arriving at 6/27/2026 5:45:00 PM. 50 Economy ticket for $223 per person are available. Travel duration is 68h 25m

Did you know that if you travel from Mexico City to San Diego via Tijuana, BC, you can save more than $93? You can find the corresponding connections below.
- ACN Autobuses
  
  45h 35m
  
  0
  
  10:00 PM
  
  Mexico City
  Calz. Ignacio Zaragoza
  
  4:33 PM
  
  Tijuana, BC
  Centro Bus Stop
  
  0
  
  Economy
  
  $124
  
  A Bus from ACN Autobuses goes from Calz. Ignacio Zaragoza, Mexico City (Mexico) at 6/23/2026 10:00:00 PM to Centro Bus Stop, Tijuana, BC (Mexico) arriving at 6/25/2026 4:33:00 PM. 50 Economy ticket for $124 per person are available. Travel duration is 43h 33m
- Greyhound US
  
  1h 35m
  
  0
  
  5:00 PM
  
  Tijuana, BC
  Central Bus Station
  
  6:35 PM
  
  San Diego
  San Ysidro Transit Center
  
  0
  
  Economy
  
  $5
  
  A Bus from Greyhound US goes from Central Bus Station, Tijuana, BC (Mexico) at 6/25/2026 5:00:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 6/25/2026 6:35:00 PM. 50 Economy ticket for $5 per person are available. Travel duration is 1h 35m
Travel Time is 19h 35m shorter, and you will save $93

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Flix Mexico	70h 5m	2:40 PM	Mexico City	San Pedro Santa Clara Bus Stop	11:45 AM	San Diego	Old Town Transit Center	Economy	$220	A Bus from Flix Mexico goes from San Pedro Santa Clara Bus Stop, Mexico City (Mexico) at 6/25/2026 2:40:00 PM to Old Town Transit Center, San Diego (USA) arriving at 6/28/2026 11:45:00 AM. 50 Economy ticket for $220 per person are available. Travel duration is 70h 5m
Flix Mexico	68h 25m	10:20 PM	Mexico City	San Pedro Santa Clara Bus Stop	5:45 PM	San Diego	Old Town Transit Center	Economy	$220	A Bus from Flix Mexico goes from San Pedro Santa Clara Bus Stop, Mexico City (Mexico) at 6/25/2026 10:20:00 PM to Old Town Transit Center, San Diego (USA) arriving at 6/28/2026 5:45:00 PM. 50 Economy ticket for $220 per person are available. Travel duration is 68h 25m
Flix Mexico	69h 40m	3:05 PM	Mexico City	Fórum Buenavista	11:45 AM	San Diego	Old Town Transit Center	Economy	$220	A Bus from Flix Mexico goes from Fórum Buenavista, Mexico City (Mexico) at 6/25/2026 3:05:00 PM to Old Town Transit Center, San Diego (USA) arriving at 6/28/2026 11:45:00 AM. 50 Economy ticket for $220 per person are available. Travel duration is 69h 40m
Flix Mexico	68h 0m	10:45 PM	Mexico City	Fórum Buenavista	5:45 PM	San Diego	Old Town Transit Center	Economy	$220	A Bus from Flix Mexico goes from Fórum Buenavista, Mexico City (Mexico) at 6/25/2026 10:45:00 PM to Old Town Transit Center, San Diego (USA) arriving at 6/28/2026 5:45:00 PM. 50 Economy ticket for $220 per person are available. Travel duration is 68h 0m
Flix Mexico	72h 55m	10:20 PM	Mexico City	San Pedro Santa Clara Bus Stop	10:15 PM	San Diego	Seaport Village	Economy	$222	A Bus from Flix Mexico goes from San Pedro Santa Clara Bus Stop, Mexico City (Mexico) at 6/25/2026 10:20:00 PM to Seaport Village, San Diego (USA) arriving at 6/28/2026 10:15:00 PM. 50 Economy ticket for $222 per person are available. Travel duration is 72h 55m

Did you know that if you travel from Mexico City to San Diego via Tijuana, BC, you can save more than $91? You can find the corresponding connections below.
- ACN Autobuses
  
  45h 35m
  
  0
  
  10:00 PM
  
  Mexico City
  Calz. Ignacio Zaragoza
  
  4:33 PM
  
  Tijuana, BC
  Centro Bus Stop
  
  0
  
  Economy
  
  $124
  
  A Bus from ACN Autobuses goes from Calz. Ignacio Zaragoza, Mexico City (Mexico) at 6/23/2026 10:00:00 PM to Centro Bus Stop, Tijuana, BC (Mexico) arriving at 6/25/2026 4:33:00 PM. 50 Economy ticket for $124 per person are available. Travel duration is 43h 33m
- Greyhound US
  
  1h 35m
  
  0
  
  5:00 PM
  
  Tijuana, BC
  Central Bus Station
  
  6:35 PM
  
  San Diego
  San Ysidro Transit Center
  
  0
  
  Economy
  
  $5
  
  A Bus from Greyhound US goes from Central Bus Station, Tijuana, BC (Mexico) at 6/25/2026 5:00:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 6/25/2026 6:35:00 PM. 50 Economy ticket for $5 per person are available. Travel duration is 1h 35m
Travel Time is 21h 25m shorter, and you will save $91

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Flix Mexico	70h 5m	2:40 PM	Mexico City	San Pedro Santa Clara Bus Stop	11:45 AM	San Diego	Old Town Transit Center	Economy	$220	A Bus from Flix Mexico goes from San Pedro Santa Clara Bus Stop, Mexico City (Mexico) at 6/26/2026 2:40:00 PM to Old Town Transit Center, San Diego (USA) arriving at 6/29/2026 11:45:00 AM. 50 Economy ticket for $220 per person are available. Travel duration is 70h 5m
Flix Mexico	69h 40m	3:05 PM	Mexico City	Fórum Buenavista	11:45 AM	San Diego	Old Town Transit Center	Economy	$220	A Bus from Flix Mexico goes from Fórum Buenavista, Mexico City (Mexico) at 6/26/2026 3:05:00 PM to Old Town Transit Center, San Diego (USA) arriving at 6/29/2026 11:45:00 AM. 50 Economy ticket for $220 per person are available. Travel duration is 69h 40m
Flix Mexico	68h 25m	10:20 PM	Mexico City	San Pedro Santa Clara Bus Stop	5:45 PM	San Diego	Old Town Transit Center	Economy	$223	A Bus from Flix Mexico goes from San Pedro Santa Clara Bus Stop, Mexico City (Mexico) at 6/26/2026 10:20:00 PM to Old Town Transit Center, San Diego (USA) arriving at 6/29/2026 5:45:00 PM. 50 Economy ticket for $223 per person are available. Travel duration is 68h 25m
Flix Mexico	70h 40m	2:40 PM	Mexico City	San Pedro Santa Clara Bus Stop	12:20 PM	San Diego	San Ysidro Transit Center	Economy	$223	A Bus from Flix Mexico goes from San Pedro Santa Clara Bus Stop, Mexico City (Mexico) at 6/26/2026 2:40:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 6/29/2026 12:20:00 PM. 50 Economy ticket for $223 per person are available. Travel duration is 70h 40m
Flix Mexico	68h 0m	10:45 PM	Mexico City	Fórum Buenavista	5:45 PM	San Diego	Old Town Transit Center	Economy	$223	A Bus from Flix Mexico goes from Fórum Buenavista, Mexico City (Mexico) at 6/26/2026 10:45:00 PM to Old Town Transit Center, San Diego (USA) arriving at 6/29/2026 5:45:00 PM. 50 Economy ticket for $223 per person are available. Travel duration is 68h 0m

Did you know that if you travel from Mexico City to San Diego via Tijuana, BC, you can save more than $91? You can find the corresponding connections below.
- ACN Autobuses
  
  45h 35m
  
  0
  
  10:00 PM
  
  Mexico City
  Calz. Ignacio Zaragoza
  
  4:33 PM
  
  Tijuana, BC
  Centro Bus Stop
  
  0
  
  Economy
  
  $124
  
  A Bus from ACN Autobuses goes from Calz. Ignacio Zaragoza, Mexico City (Mexico) at 6/23/2026 10:00:00 PM to Centro Bus Stop, Tijuana, BC (Mexico) arriving at 6/25/2026 4:33:00 PM. 50 Economy ticket for $124 per person are available. Travel duration is 43h 33m
- Greyhound US
  
  1h 35m
  
  0
  
  5:00 PM
  
  Tijuana, BC
  Central Bus Station
  
  6:35 PM
  
  San Diego
  San Ysidro Transit Center
  
  0
  
  Economy
  
  $5
  
  A Bus from Greyhound US goes from Central Bus Station, Tijuana, BC (Mexico) at 6/25/2026 5:00:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 6/25/2026 6:35:00 PM. 50 Economy ticket for $5 per person are available. Travel duration is 1h 35m
Travel Time is 21h 25m shorter, and you will save $91

Best Price Offer: The price for the cheapest bus from Mexico City to San Diego is $217 on 6/23/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Mexico City and San Diego

See here how frequent the connections between Mexico City and San Diego are, during different times and days of the week.

Wednesday is the busiest day, with more than 22 daily buses from Mexico City to San Diego. Saturday has instead the fewest connections, with only 6 daily coaches between Mexico City and San Diego.

The busiest time of the day is the Evening, with 68 buses from Mexico City to San Diego, while Morning sees the fewest connections between Mexico City and San Diego, with 8 offers.

Facts about the bus from Mexico City to San Diego

Compare all providers like Flix Mexico that travel 14 times every day by bus from Mexico City to San Diego in one click! Book your bus ticket from Mexico City to San Diego starting from $217!

Cheapest Bus	$217
Fastest Bus	65h 10m
Earliest Bus	3:05 PM
Latest Bus	10:45 PM
Daily Bus Routes	14 Ø
Distance	1,443.3 miles
Bus Companies	Flix Mexico

Cheapest bus connections from Mexico City to San Diego

Every day, 14 buses from 1 bus companies leave Mexico City for San Diego: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 06/20/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 06/14

Monday 06/15

Tuesday 06/16

Wednesday 06/17

Thursday 06/18

Friday 06/19

Saturday 06/20

$314

Sunday 06/21

$220

Monday 06/22

$219

Tuesday 06/23

$223

Wednesday 06/24

$222

Thursday 06/25

$234

Friday 06/26

$223

Saturday 06/27

$240

Sunday 06/28

$219

Monday 06/29

Tuesday 06/30

$238

Wednesday 07/01

$220

Thursday 07/02

$232

Friday 07/03

Saturday 07/04

Sunday 07/05

$229

Monday 07/06

Tuesday 07/07

Wednesday 07/08

Thursday 07/09

Friday 07/10

$222

Saturday 07/11

The cheapest time to travel from Mexico City to San Diego

See here on which day and which time of the day you can find the cheapest bus ticket from Mexico City to San Diego, for the next 30 days.

With a price starting from $216, Monday is the cheapest day for a bus from Mexico City to San Diego. Wednesday instead is the most expensive day with prices starting from $220.

Morning is the cheapest day time for bus tickets from Mexico City to San Diego, with $217. Evening is the most expensive time of the day with prices starting from $219.

How to save money travelling from Mexico City to San Diego

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Mexico City to San Diego in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Mexico City to San Diego, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Mexico City to San Diego are also emptier.

All bus stations and stops in Mexico City and San Diego

In the map below, you can see where to find all bus stations in Mexico City and San Diego.

Terminal del Sur

Av. Taxqueña 1320

Observatorio Central Bus Station

Av Río de Tacubaya 122 232

Eje Central Bus Stop

Avenida Lázaro Cárdenas & Calle Poniente 112 Avenida Lázaro Cárdenas & Calle Poniente 112

Moctezuma Bus Stop

Ampliación 7 de Julio

Terminal Antas Tla

Emiliano Zapata 97

Old Town Transit Center

Congress Street 2727

San Ysidro Transit Center

E San Ysidro Blvd 723

Santa Fe Depot

Kettner Blvd 1050

Seaport Village

W Harbor Dr 789

La Jolla Village

Hyatt Regency

Service and Comfort on the bus from Mexico City to San Diego

Want to know which seat classes are available on the buses from Mexico City to San Diego? Or which bus companies serve the route Mexico City to San Diego? Below you will find answers to your questions.

FAQs about the Mexico City to San Diego bus

How much does a Mexico City San Diego bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $217 and takes 72h 10m to reach San Diego. Compare offers to save money!

How much could I save by comparing buses from Mexico City to San Diego?

This route is offered by 1 companies with a range of ticket prices between $217 and $337. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to San Diego.

On average, how many connections are available from Mexico City to San Diego each day?

Every day, the Mexico City to San Diego bus route is served by approximately 14 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Mexico City to San Diego take?

The fastest bus from Mexico City to San Diego is offered by Flix Mexico and takes 65h 10m. Bus tickets for this connection cost $222. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Mexico City to San Diego?

The earliest bus arriving in San Diego from Mexico City starts at 3:05 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Mexico City to San Diego?

The latest bus trip departing from Mexico City for San Diego starts at 10:45 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Mexico City San Diego route?

When traveling by bus from Mexico City to San Diego, passengers can travel with Flix Mexico. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Mexico City and San Diego?

You can check all the direct connections between Mexico City and San Diego by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Flix Mexico.

What can I take with me on the Mexico City to San Diego bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Mexico City San Diego bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Mexico City San Diego bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Mexico City to San Diego on your planned travel date.

How does CheckMyBus find the best bus deals from Mexico City to San Diego?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 14 daily trips between Mexico City and San Diego. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Mexico City to San Diego?

Prices and availability for 14 trips between Mexico City and San Diego change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Mexico City to San Diego

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Mexico City and to San Diego

Here’s an overview of the most popular bus routes to Mexico City and to San Diego. Simply click on the connection of your choice, and you will find all the details about your bus route!