What is the best way to travel from Santa Maria, CA to San Diego?
Looking for a trip? Compare all the available Flights for the journey to San Diego from Santa Maria, CA. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all available companies to find your perfect trip!
What is the cheapest way to reach San Diego from Santa Maria, CA?
You can get to San Diego with just $196 by taking a Flight from Skyscanner, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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Skyscanner1h 22m06:00 AMSan Luis Obispo County AirportSan Luis Obispo County Airport7:22 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Skyscanner goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/22/2025 6:00:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/22/2025 7:22:00 AM. 50 Economy ticket for $197 per person are available. Travel duration is 1h 22m
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Skyscanner1h 25m05:20 PMSan Luis Obispo County AirportSan Luis Obispo County Airport6:45 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Skyscanner goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/22/2025 5:20:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/22/2025 6:45:00 PM. 50 Economy ticket for $224 per person are available. Travel duration is 1h 25m
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Alaska Airlines24h 13m07:45 PMSan Luis Obispo County AirportSan Luis Obispo County Airport7:58 PMTijuana AirportTijuana Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/22/2025 7:45:00 PM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 12/23/2025 7:58:00 PM. 50 Economy ticket for $399 per person are available. Travel duration is 24h 13m
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Alaska Airlines24h 0m07:45 PMSan Luis Obispo County AirportSan Luis Obispo County Airport7:45 PMTijuana AirportTijuana Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/22/2025 7:45:00 PM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 12/23/2025 7:45:00 PM. 50 Economy ticket for $433 per person are available. Travel duration is 24h 0m
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Alaska Airlines11h 10m06:00 AMSan Luis Obispo County AirportSan Luis Obispo County Airport5:10 PMTijuana AirportTijuana Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/22/2025 6:00:00 AM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 12/22/2025 5:10:00 PM. 50 Economy ticket for $462 per person are available. Travel duration is 11h 10m
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Alaska Airlines13h 45m06:00 AMSan Luis Obispo County AirportSan Luis Obispo County Airport7:45 PMTijuana AirportTijuana Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/22/2025 6:00:00 AM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 12/22/2025 7:45:00 PM. 50 Economy ticket for $478 per person are available. Travel duration is 13h 45m
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Alaska Airlines18h 25m07:45 PMSan Luis Obispo County AirportSan Luis Obispo County Airport2:10 PMTijuana AirportTijuana Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/22/2025 7:45:00 PM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 12/23/2025 2:10:00 PM. 50 Economy ticket for $494 per person are available. Travel duration is 18h 25m
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United Airlines5h 52m06:23 PMSan Luis Obispo County AirportSan Luis Obispo County Airport12:15 AMSan Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/22/2025 6:23:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/23/2025 12:15:00 AM. 50 Economy ticket for $565 per person are available. Travel duration is 5h 52m
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Alaska Airlines5h 42m05:25 PMSan Luis Obispo County AirportSan Luis Obispo County Airport11:07 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/22/2025 5:25:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/22/2025 11:07:00 PM. 50 Economy ticket for $576 per person are available. Travel duration is 5h 42m
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Alaska Airlines6h 54m03:55 PMSan Luis Obispo County AirportSan Luis Obispo County Airport10:49 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/22/2025 3:55:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/22/2025 10:49:00 PM. 50 Economy ticket for $586 per person are available. Travel duration is 6h 54m
Cheapest Flights Monday
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Skyscanner1h 22m06:00 AMSan Luis Obispo County AirportSan Luis Obispo County Airport7:22 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Skyscanner goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/23/2025 6:00:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/23/2025 7:22:00 AM. 50 Economy ticket for $197 per person are available. Travel duration is 1h 22m
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Skyscanner1h 25m05:20 PMSan Luis Obispo County AirportSan Luis Obispo County Airport6:45 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Skyscanner goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/23/2025 5:20:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/23/2025 6:45:00 PM. 50 Economy ticket for $363 per person are available. Travel duration is 1h 25m
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Alaska Airlines13h 58m06:00 AMSan Luis Obispo County AirportSan Luis Obispo County Airport7:58 PMTijuana AirportTijuana Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/23/2025 6:00:00 AM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 12/23/2025 7:58:00 PM. 50 Economy ticket for $443 per person are available. Travel duration is 13h 58m
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Alaska Airlines11h 10m06:00 AMSan Luis Obispo County AirportSan Luis Obispo County Airport5:10 PMTijuana AirportTijuana Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/23/2025 6:00:00 AM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 12/23/2025 5:10:00 PM. 50 Economy ticket for $504 per person are available. Travel duration is 11h 10m
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Skyscanner3h 27m07:03 AMSan Luis Obispo County AirportSan Luis Obispo County Airport10:30 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Skyscanner goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/23/2025 7:03:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/23/2025 10:30:00 AM. 50 Economy ticket for $759 per person are available. Travel duration is 3h 27m
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Alaska Airlines6h 50m03:55 PMSan Luis Obispo County AirportSan Luis Obispo County Airport10:45 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/23/2025 3:55:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/23/2025 10:45:00 PM. 50 Economy ticket for $812 per person are available. Travel duration is 6h 50m
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Alaska Airlines5h 42m05:25 PMSan Luis Obispo County AirportSan Luis Obispo County Airport11:07 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/23/2025 5:25:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/23/2025 11:07:00 PM. 50 Economy ticket for $832 per person are available. Travel duration is 5h 42m
Cheapest Flights Tuesday
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Skyscanner1h 22m06:00 AMSan Luis Obispo County AirportSan Luis Obispo County Airport7:22 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Skyscanner goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/25/2025 6:00:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/25/2025 7:22:00 AM. 50 Economy ticket for $196 per person are available. Travel duration is 1h 22m
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Skyscanner1h 25m05:24 PMSan Luis Obispo County AirportSan Luis Obispo County Airport6:49 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Skyscanner goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/25/2025 5:24:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/25/2025 6:49:00 PM. 50 Economy ticket for $223 per person are available. Travel duration is 1h 25m
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Alaska Airlines13h 58m06:00 AMSan Luis Obispo County AirportSan Luis Obispo County Airport7:58 PMTijuana AirportTijuana Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/25/2025 6:00:00 AM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 12/25/2025 7:58:00 PM. 50 Economy ticket for $473 per person are available. Travel duration is 13h 58m
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Alaska Airlines13h 45m06:00 AMSan Luis Obispo County AirportSan Luis Obispo County Airport7:45 PMTijuana AirportTijuana Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/25/2025 6:00:00 AM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 12/25/2025 7:45:00 PM. 50 Economy ticket for $505 per person are available. Travel duration is 13h 45m
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Alaska Airlines5h 42m05:25 PMSan Luis Obispo County AirportSan Luis Obispo County Airport11:07 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/25/2025 5:25:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/25/2025 11:07:00 PM. 50 Economy ticket for $513 per person are available. Travel duration is 5h 42m
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Alaska Airlines6h 50m03:55 PMSan Luis Obispo County AirportSan Luis Obispo County Airport10:45 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/25/2025 3:55:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/25/2025 10:45:00 PM. 50 Economy ticket for $543 per person are available. Travel duration is 6h 50m
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Alaska Airlines24h 0m07:45 PMSan Luis Obispo County AirportSan Luis Obispo County Airport7:45 PMTijuana AirportTijuana Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/25/2025 7:45:00 PM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 12/26/2025 7:45:00 PM. 50 Economy ticket for $549 per person are available. Travel duration is 24h 0m
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United Airlines4h 47m08:15 AMSan Luis Obispo County AirportSan Luis Obispo County Airport1:02 PMSan Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/25/2025 8:15:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/25/2025 1:02:00 PM. 50 Economy ticket for $563 per person are available. Travel duration is 4h 47m
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Alaska Airlines21h 25m07:45 PMSan Luis Obispo County AirportSan Luis Obispo County Airport5:10 PMTijuana AirportTijuana Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/25/2025 7:45:00 PM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 12/26/2025 5:10:00 PM. 50 Economy ticket for $564 per person are available. Travel duration is 21h 25m
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Alaska Airlines18h 25m07:45 PMSan Luis Obispo County AirportSan Luis Obispo County Airport2:10 PMTijuana AirportTijuana Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/25/2025 7:45:00 PM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 12/26/2025 2:10:00 PM. 50 Economy ticket for $575 per person are available. Travel duration is 18h 25m
Cheapest Flights Thursday
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Skyscanner1h 22m06:00 AMSan Luis Obispo County AirportSan Luis Obispo County Airport7:22 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Skyscanner goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/28/2025 6:00:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/28/2025 7:22:00 AM. 50 Economy ticket for $197 per person are available. Travel duration is 1h 22m
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Skyscanner1h 25m05:20 PMSan Luis Obispo County AirportSan Luis Obispo County Airport6:45 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Skyscanner goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/28/2025 5:20:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/28/2025 6:45:00 PM. 50 Economy ticket for $224 per person are available. Travel duration is 1h 25m
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Alaska Airlines24h 0m07:45 PMSan Luis Obispo County AirportSan Luis Obispo County Airport7:45 PMTijuana AirportTijuana Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/28/2025 7:45:00 PM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 12/29/2025 7:45:00 PM. 50 Economy ticket for $409 per person are available. Travel duration is 24h 0m
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Alaska Airlines18h 25m07:45 PMSan Luis Obispo County AirportSan Luis Obispo County Airport2:10 PMTijuana AirportTijuana Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/28/2025 7:45:00 PM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 12/29/2025 2:10:00 PM. 50 Economy ticket for $409 per person are available. Travel duration is 18h 25m
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United Airlines6h 27m02:21 PMSan Luis Obispo County AirportSan Luis Obispo County Airport8:48 PMSan Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/28/2025 2:21:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/28/2025 8:48:00 PM. 50 Economy ticket for $566 per person are available. Travel duration is 6h 27m
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United Airlines5h 52m06:23 PMSan Luis Obispo County AirportSan Luis Obispo County Airport12:15 AMSan Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/28/2025 6:23:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/29/2025 12:15:00 AM. 50 Economy ticket for $566 per person are available. Travel duration is 5h 52m
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Alaska Airlines6h 50m03:55 PMSan Luis Obispo County AirportSan Luis Obispo County Airport10:45 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/28/2025 3:55:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/28/2025 10:45:00 PM. 50 Economy ticket for $676 per person are available. Travel duration is 6h 50m
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Alaska Airlines11h 10m06:00 AMSan Luis Obispo County AirportSan Luis Obispo County Airport5:10 PMTijuana AirportTijuana Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/28/2025 6:00:00 AM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 12/28/2025 5:10:00 PM. 50 Economy ticket for $914 per person are available. Travel duration is 11h 10m
Cheapest Flights Sunday
What are the fastest trips from Santa Maria, CA to San Diego?
You can get to San Diego from Santa Maria, CA in just 1h 22m with a Flight from Skyscanner. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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Skyscanner1h 22m06:00 AMSan Luis Obispo County AirportSan Luis Obispo County Airport7:22 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Skyscanner goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/22/2025 6:00:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/22/2025 7:22:00 AM. 50 Economy ticket for $197 per person are available. Travel duration is 1h 22m
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Skyscanner1h 25m05:20 PMSan Luis Obispo County AirportSan Luis Obispo County Airport6:45 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Skyscanner goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/22/2025 5:20:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/22/2025 6:45:00 PM. 50 Economy ticket for $224 per person are available. Travel duration is 1h 25m
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Alaska Airlines5h 42m05:25 PMSan Luis Obispo County AirportSan Luis Obispo County Airport11:07 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/22/2025 5:25:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/22/2025 11:07:00 PM. 50 Economy ticket for $576 per person are available. Travel duration is 5h 42m
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United Airlines5h 52m06:23 PMSan Luis Obispo County AirportSan Luis Obispo County Airport12:15 AMSan Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/22/2025 6:23:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/23/2025 12:15:00 AM. 50 Economy ticket for $565 per person are available. Travel duration is 5h 52m
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Alaska Airlines6h 54m03:55 PMSan Luis Obispo County AirportSan Luis Obispo County Airport10:49 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/22/2025 3:55:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/22/2025 10:49:00 PM. 50 Economy ticket for $586 per person are available. Travel duration is 6h 54m
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Alaska Airlines11h 10m06:00 AMSan Luis Obispo County AirportSan Luis Obispo County Airport5:10 PMTijuana AirportTijuana Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/22/2025 6:00:00 AM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 12/22/2025 5:10:00 PM. 50 Economy ticket for $462 per person are available. Travel duration is 11h 10m
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Alaska Airlines13h 45m06:00 AMSan Luis Obispo County AirportSan Luis Obispo County Airport7:45 PMTijuana AirportTijuana Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/22/2025 6:00:00 AM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 12/22/2025 7:45:00 PM. 50 Economy ticket for $478 per person are available. Travel duration is 13h 45m
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Alaska Airlines18h 25m07:45 PMSan Luis Obispo County AirportSan Luis Obispo County Airport2:10 PMTijuana AirportTijuana Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/22/2025 7:45:00 PM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 12/23/2025 2:10:00 PM. 50 Economy ticket for $494 per person are available. Travel duration is 18h 25m
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Alaska Airlines24h 0m07:45 PMSan Luis Obispo County AirportSan Luis Obispo County Airport7:45 PMTijuana AirportTijuana Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/22/2025 7:45:00 PM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 12/23/2025 7:45:00 PM. 50 Economy ticket for $433 per person are available. Travel duration is 24h 0m
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Alaska Airlines24h 13m07:45 PMSan Luis Obispo County AirportSan Luis Obispo County Airport7:58 PMTijuana AirportTijuana Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/22/2025 7:45:00 PM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 12/23/2025 7:58:00 PM. 50 Economy ticket for $399 per person are available. Travel duration is 24h 13m
Fastest Flights Monday
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Skyscanner1h 22m06:00 AMSan Luis Obispo County AirportSan Luis Obispo County Airport7:22 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Skyscanner goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/23/2025 6:00:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/23/2025 7:22:00 AM. 50 Economy ticket for $197 per person are available. Travel duration is 1h 22m
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Skyscanner1h 25m05:20 PMSan Luis Obispo County AirportSan Luis Obispo County Airport6:45 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Skyscanner goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/23/2025 5:20:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/23/2025 6:45:00 PM. 50 Economy ticket for $363 per person are available. Travel duration is 1h 25m
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Skyscanner3h 27m07:03 AMSan Luis Obispo County AirportSan Luis Obispo County Airport10:30 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Skyscanner goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/23/2025 7:03:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/23/2025 10:30:00 AM. 50 Economy ticket for $759 per person are available. Travel duration is 3h 27m
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Alaska Airlines5h 42m05:25 PMSan Luis Obispo County AirportSan Luis Obispo County Airport11:07 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/23/2025 5:25:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/23/2025 11:07:00 PM. 50 Economy ticket for $832 per person are available. Travel duration is 5h 42m
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Alaska Airlines6h 50m03:55 PMSan Luis Obispo County AirportSan Luis Obispo County Airport10:45 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/23/2025 3:55:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/23/2025 10:45:00 PM. 50 Economy ticket for $812 per person are available. Travel duration is 6h 50m
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Alaska Airlines11h 10m06:00 AMSan Luis Obispo County AirportSan Luis Obispo County Airport5:10 PMTijuana AirportTijuana Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/23/2025 6:00:00 AM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 12/23/2025 5:10:00 PM. 50 Economy ticket for $504 per person are available. Travel duration is 11h 10m
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Alaska Airlines13h 58m06:00 AMSan Luis Obispo County AirportSan Luis Obispo County Airport7:58 PMTijuana AirportTijuana Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/23/2025 6:00:00 AM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 12/23/2025 7:58:00 PM. 50 Economy ticket for $443 per person are available. Travel duration is 13h 58m
Fastest Flights Tuesday
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Skyscanner1h 22m06:00 AMSan Luis Obispo County AirportSan Luis Obispo County Airport7:22 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Skyscanner goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/25/2025 6:00:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/25/2025 7:22:00 AM. 50 Economy ticket for $196 per person are available. Travel duration is 1h 22m
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Skyscanner1h 25m05:24 PMSan Luis Obispo County AirportSan Luis Obispo County Airport6:49 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Skyscanner goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/25/2025 5:24:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/25/2025 6:49:00 PM. 50 Economy ticket for $223 per person are available. Travel duration is 1h 25m
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United Airlines4h 47m08:15 AMSan Luis Obispo County AirportSan Luis Obispo County Airport1:02 PMSan Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/25/2025 8:15:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/25/2025 1:02:00 PM. 50 Economy ticket for $563 per person are available. Travel duration is 4h 47m
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Alaska Airlines5h 42m05:25 PMSan Luis Obispo County AirportSan Luis Obispo County Airport11:07 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/25/2025 5:25:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/25/2025 11:07:00 PM. 50 Economy ticket for $513 per person are available. Travel duration is 5h 42m
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Alaska Airlines6h 50m03:55 PMSan Luis Obispo County AirportSan Luis Obispo County Airport10:45 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/25/2025 3:55:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/25/2025 10:45:00 PM. 50 Economy ticket for $543 per person are available. Travel duration is 6h 50m
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Alaska Airlines13h 45m06:00 AMSan Luis Obispo County AirportSan Luis Obispo County Airport7:45 PMTijuana AirportTijuana Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/25/2025 6:00:00 AM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 12/25/2025 7:45:00 PM. 50 Economy ticket for $505 per person are available. Travel duration is 13h 45m
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Alaska Airlines13h 58m06:00 AMSan Luis Obispo County AirportSan Luis Obispo County Airport7:58 PMTijuana AirportTijuana Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/25/2025 6:00:00 AM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 12/25/2025 7:58:00 PM. 50 Economy ticket for $473 per person are available. Travel duration is 13h 58m
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Alaska Airlines18h 25m07:45 PMSan Luis Obispo County AirportSan Luis Obispo County Airport2:10 PMTijuana AirportTijuana Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/25/2025 7:45:00 PM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 12/26/2025 2:10:00 PM. 50 Economy ticket for $575 per person are available. Travel duration is 18h 25m
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Alaska Airlines21h 25m07:45 PMSan Luis Obispo County AirportSan Luis Obispo County Airport5:10 PMTijuana AirportTijuana Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/25/2025 7:45:00 PM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 12/26/2025 5:10:00 PM. 50 Economy ticket for $564 per person are available. Travel duration is 21h 25m
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Alaska Airlines24h 0m07:45 PMSan Luis Obispo County AirportSan Luis Obispo County Airport7:45 PMTijuana AirportTijuana Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/25/2025 7:45:00 PM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 12/26/2025 7:45:00 PM. 50 Economy ticket for $549 per person are available. Travel duration is 24h 0m
Fastest Flights Thursday
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Skyscanner1h 22m06:00 AMSan Luis Obispo County AirportSan Luis Obispo County Airport7:22 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Skyscanner goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/28/2025 6:00:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/28/2025 7:22:00 AM. 50 Economy ticket for $197 per person are available. Travel duration is 1h 22m
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Skyscanner1h 25m05:20 PMSan Luis Obispo County AirportSan Luis Obispo County Airport6:45 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Skyscanner goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/28/2025 5:20:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/28/2025 6:45:00 PM. 50 Economy ticket for $224 per person are available. Travel duration is 1h 25m
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United Airlines5h 52m06:23 PMSan Luis Obispo County AirportSan Luis Obispo County Airport12:15 AMSan Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/28/2025 6:23:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/29/2025 12:15:00 AM. 50 Economy ticket for $566 per person are available. Travel duration is 5h 52m
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United Airlines6h 27m02:21 PMSan Luis Obispo County AirportSan Luis Obispo County Airport8:48 PMSan Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/28/2025 2:21:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/28/2025 8:48:00 PM. 50 Economy ticket for $566 per person are available. Travel duration is 6h 27m
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Alaska Airlines6h 50m03:55 PMSan Luis Obispo County AirportSan Luis Obispo County Airport10:45 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/28/2025 3:55:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/28/2025 10:45:00 PM. 50 Economy ticket for $676 per person are available. Travel duration is 6h 50m
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Alaska Airlines11h 10m06:00 AMSan Luis Obispo County AirportSan Luis Obispo County Airport5:10 PMTijuana AirportTijuana Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/28/2025 6:00:00 AM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 12/28/2025 5:10:00 PM. 50 Economy ticket for $914 per person are available. Travel duration is 11h 10m
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Alaska Airlines18h 25m07:45 PMSan Luis Obispo County AirportSan Luis Obispo County Airport2:10 PMTijuana AirportTijuana Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/28/2025 7:45:00 PM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 12/29/2025 2:10:00 PM. 50 Economy ticket for $409 per person are available. Travel duration is 18h 25m
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Alaska Airlines24h 0m07:45 PMSan Luis Obispo County AirportSan Luis Obispo County Airport7:45 PMTijuana AirportTijuana Airport0EconomyA Flight from Alaska Airlines goes from San Luis Obispo County Airport, San Luis Obispo County Airport (USA) at 12/28/2025 7:45:00 PM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 12/29/2025 7:45:00 PM. 50 Economy ticket for $409 per person are available. Travel duration is 24h 0m
Fastest Flights Sunday
Here you will find all operators and timetables for a
Bus from Santa Maria, CA to San Diego
What are the most popular stations in Santa Maria, CA and San Diego?
In Santa Maria, CA, you will usually depart from Nicholson Ave, Ihop or Transit Center, while in San Diego you will be arriving at San Ysidro Transit Center, University Av & Bancroft St Bus Stop or Old Town Transit Center, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to San Diego from Santa Maria, CA? With 8 connections between Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Santa Maria, CA and San Diego, you can pay as low as $196 with a Flight from Skyscanner.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from Skyscanner: you will get to San Diego in just 1h 22m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Santa Maria, CA and San Diego are Alaska Airlines, Skyscanner and United Airlines, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Santa Maria, CA and San Diego is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Santa Maria Airport or to San Diego Airport, and look at flights from San Luis Obispo County Airport, and landing at Tijuana Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Santa Maria, CA to San Diego?
The most popular companies between Santa Maria, CA and San Diego, are Alaska Airlines, Skyscanner and United Airlines. Be sure to check their seat class offers and the amenities that they provide.
Airlines: Alaska Airlines, Skyscanner and United Airlines
All you need to know when you travel from Santa Maria, CA to San Diego
Check all information on comfort and services on all modes of transports from Santa Maria, CA to San Diego. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Santa Maria, CA to San Diego
How can I reach San Diego from Santa Maria, CA?
Every day, there are on average 8 connections between Flight, with which you can get to San Diego from Santa Maria, CA.
How far is San Diego from Santa Maria, CA?
The distance between Santa Maria, CA and San Diego is 243.5 miles.
What is the most ecofriendly mode of transport between Santa Maria, CA and San Diego?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 11 kgs of CO2, a train 14 kgs, a car 67 kgs, and a flight 96 kgs.
What is the cheapest mode of transport from Santa Maria, CA to San Diego?
You can get to San Diego with just $196 by taking a Flight from Skyscanner.
What is the fastest way to get from Santa Maria, CA to San Diego?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to San Diego in just 1h 22m with a Flight from Skyscanner.
More routes to Santa Maria, CA and to San Diego
Looking for more options? Here you can see the most popular routes to Santa Maria, CA and to San Diego. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Santa Maria, CA
- Tijuana, BC to Santa Maria, CA
