Bus Frederick, MD to Chicago: Compare prices and save money

Compare all timetables for the bus from Frederick, MD to Chicago

Here is a selection of the cheapest bus trips from the schedule from Frederick, MD to Chicago from various bus operators like Greyhound US for the next days.

today

tomorrow

Saturday

$84

Sunday

$75

Monday

Tuesday

Wednesday

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	15h 25m	7:35 PM	Frederick, MD	Bus Stop	10:00 AM	Chicago	Downtown Bus Station	Economy	$84	A Bus from Greyhound US goes from Bus Stop, Frederick, MD (USA) at 12/6/2025 7:35:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/7/2025 10:00:00 AM. 50 Economy ticket for $84 per person are available. Travel duration is 15h 25m
Greyhound US	17h 50m	6:45 AM	Frederick, MD	Bus Stop	11:35 PM	Chicago	Downtown Bus Station	Economy	$94	A Bus from Greyhound US goes from Bus Stop, Frederick, MD (USA) at 12/6/2025 6:45:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/6/2025 11:35:00 PM. 50 Economy ticket for $94 per person are available. Travel duration is 17h 50m
Greyhound US	27h 55m	5:05 AM	Frederick, MD	Bus Stop	8:00 AM	Chicago	Union Station	Economy	$107	A Bus from Greyhound US goes from Bus Stop, Frederick, MD (USA) at 12/6/2025 5:05:00 AM to Union Station, Chicago (USA) arriving at 12/7/2025 8:00:00 AM. 50 Economy ticket for $107 per person are available. Travel duration is 27h 55m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	15h 25m	7:35 PM	Frederick, MD	Bus Stop	10:00 AM	Chicago	Downtown Bus Station	Economy	$75	A Bus from Greyhound US goes from Bus Stop, Frederick, MD (USA) at 12/7/2025 7:35:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/8/2025 10:00:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 15h 25m
Greyhound US	18h 50m	7:35 PM	Frederick, MD	Bus Stop	1:25 PM	Chicago	95th Red Line Station	Economy	$89	A Bus from Greyhound US goes from Bus Stop, Frederick, MD (USA) at 12/7/2025 7:35:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/8/2025 1:25:00 PM. 50 Economy ticket for $89 per person are available. Travel duration is 18h 50m
Greyhound US	27h 55m	5:05 AM	Frederick, MD	Bus Stop	8:00 AM	Chicago	Canal & Van Buren	Economy	$103	A Bus from Greyhound US goes from Bus Stop, Frederick, MD (USA) at 12/7/2025 5:05:00 AM to Canal & Van Buren, Chicago (USA) arriving at 12/8/2025 8:00:00 AM. 50 Economy ticket for $103 per person are available. Travel duration is 27h 55m
Greyhound US	17h 15m	6:45 AM	Frederick, MD	Bus Stop	11:00 PM	Chicago	95th Red Line Station	Economy	$107	A Bus from Greyhound US goes from Bus Stop, Frederick, MD (USA) at 12/7/2025 6:45:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/7/2025 11:00:00 PM. 50 Economy ticket for $107 per person are available. Travel duration is 17h 15m
Greyhound US	17h 50m	6:45 AM	Frederick, MD	Bus Stop	11:35 PM	Chicago	Downtown Bus Station	Economy	$107	A Bus from Greyhound US goes from Bus Stop, Frederick, MD (USA) at 12/7/2025 6:45:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/7/2025 11:35:00 PM. 50 Economy ticket for $107 per person are available. Travel duration is 17h 50m

Best Price Offer: The price for the cheapest bus from Frederick, MD to Chicago is $75 on 12/7/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between Frederick, MD and Chicago

See here how frequent the connections between Frederick, MD and Chicago are, during different times and days of the week.

Sunday is the busiest day, with more than 10 daily buses from Frederick, MD to Chicago. Saturday has instead the fewest connections, with only 3 daily coaches between Frederick, MD and Chicago.

The busiest time of the day is the Morning, with 5 buses from Frederick, MD to Chicago, while Night sees the fewest connections between Frederick, MD and Chicago, with 3 offers.

Facts about the bus from Frederick, MD to Chicago

Compare all providers like Greyhound US that travel 6 times every day by bus from Frederick, MD to Chicago in one click! Book your bus ticket from Frederick, MD to Chicago starting from $75!

Cheapest Bus	$75
Fastest Bus	14h 25m
Earliest Bus	5:05 AM
Latest Bus	7:35 PM
Daily Bus Routes	6 Ø
Distance	563.7 miles
Bus Companies	Greyhound US

Cheapest bus connections from Frederick, MD to Chicago

Every day, 6 buses from 1 bus companies leave Frederick, MD for Chicago: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/04/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 11/30

Monday 12/01

Tuesday 12/02

Wednesday 12/03

Thursday 12/04

Friday 12/05

Saturday 12/06

$84

Sunday 12/07

$75

Monday 12/08

Tuesday 12/09

Wednesday 12/10

Thursday 12/11

$94

Friday 12/12

Saturday 12/13

Sunday 12/14

Monday 12/15

Tuesday 12/16

Wednesday 12/17

Thursday 12/18

Friday 12/19

Saturday 12/20

Sunday 12/21

Monday 12/22

Tuesday 12/23

Wednesday 12/24

Thursday 12/25

Friday 12/26

Saturday 12/27

The cheapest time to travel from Frederick, MD to Chicago

See here on which day and which time of the day you can find the cheapest bus ticket from Frederick, MD to Chicago, for the next 30 days.

With a price starting from $75, Sunday is the cheapest day for a bus from Frederick, MD to Chicago. Saturday instead is the most expensive day with prices starting from $84.

Evening is the cheapest day time for bus tickets from Frederick, MD to Chicago, with $75. Morning is the most expensive time of the day with prices starting from $94.

How to save money travelling from Frederick, MD to Chicago

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Frederick, MD to Chicago in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Frederick, MD to Chicago, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Frederick, MD to Chicago are also emptier.

All bus stations and stops in Frederick, MD and Chicago

In the map below, you can see where to find all bus stations in Frederick, MD and Chicago.

Bus Stop

Se St 100

Prospect Plaza - Dollar tree Bus Stop

95th Red Line Station

W. 95th St 14

Downtown Bus Station

West Harrison Street 630-670

Union Station

S Canal St 225

Cumberland CTA

N Cumberland Ave 5800

Canal & Van Buren

S Canal St 310-320

Service and Comfort on the bus from Frederick, MD to Chicago

Want to know which seat classes are available on the buses from Frederick, MD to Chicago? Or which bus companies serve the route Frederick, MD to Chicago? Below you will find answers to your questions.

FAQs about the Frederick, MD to Chicago bus

How much does a Frederick, MD Chicago bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $75 and takes 14h 25m to reach Chicago. Compare offers to save money!

How much could I save by comparing buses from Frederick, MD to Chicago?

This route is offered by 1 companies with a range of ticket prices between $75 and $111. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Chicago.

On average, how many connections are available from Frederick, MD to Chicago each day?

Every day, the Frederick, MD to Chicago bus route is served by approximately 6 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Frederick, MD to Chicago take?

The fastest bus from Frederick, MD to Chicago is offered by Greyhound US and takes 14h 25m. Bus tickets for this connection cost $84. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Frederick, MD to Chicago?

The earliest bus arriving in Chicago from Frederick, MD starts at 5:05 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Frederick, MD to Chicago?

The latest bus trip departing from Frederick, MD for Chicago starts at 7:35 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Frederick, MD Chicago route?

When traveling by bus from Frederick, MD to Chicago, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Frederick, MD and Chicago?

You can check all the direct connections between Frederick, MD and Chicago by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Frederick, MD to Chicago bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Frederick, MD Chicago bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Frederick, MD Chicago bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Frederick, MD to Chicago on your planned travel date.

Available seat classes which are offered on the bus route Frederick, MD to Chicago

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Frederick, MD and to Chicago

Here’s an overview of the most popular bus routes to Frederick, MD and to Chicago. Simply click on the connection of your choice, and you will find all the details about your bus route!