Bus Indianapolis to San Antonio, TX - Compare all Companies

Compare all timetables for the bus from Indianapolis to San Antonio, TX

Here is a selection of the cheapest bus trips from the schedule from Indianapolis to San Antonio, TX from various bus operators like Greyhound US or FlixBus for the next days.

today

$104

tomorrow

Tuesday

$100

Wednesday

$119

Thursday

$128

Friday

Saturday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	27h 5m	4:05 PM	Indianapolis	Central Bus Station	6:10 PM	San Antonio, TX	Bus Station	Economy	$104	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 10/4/2026 4:05:00 PM to Bus Station, San Antonio, TX (USA) arriving at 10/5/2026 6:10:00 PM. 50 Economy ticket for $104 per person are available. Travel duration is 27h 5m
Greyhound US	28h 55m	8:10 PM	Indianapolis	Central Bus Station	12:05 AM	San Antonio, TX	Bus Station	Economy	$104	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 10/4/2026 8:10:00 PM to Bus Station, San Antonio, TX (USA) arriving at 10/6/2026 12:05:00 AM. 50 Economy ticket for $104 per person are available. Travel duration is 28h 55m
Greyhound US	37h 5m	11:05 AM	Indianapolis	Central Bus Station	11:10 PM	San Antonio, TX	Pearl District	Economy	$105	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 10/4/2026 11:05:00 AM to Pearl District, San Antonio, TX (USA) arriving at 10/5/2026 11:10:00 PM. 50 Economy ticket for $105 per person are available. Travel duration is 37h 5m
Greyhound US	26h 40m	11:15 AM	Indianapolis	Central Bus Station	12:55 PM	San Antonio, TX	Bus Station	Economy	$113	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 10/4/2026 11:15:00 AM to Bus Station, San Antonio, TX (USA) arriving at 10/5/2026 12:55:00 PM. 50 Economy ticket for $113 per person are available. Travel duration is 26h 40m
Greyhound US	38h 5m	11:15 AM	Indianapolis	Central Bus Station	12:20 AM	San Antonio, TX	Pearl District	Economy	$114	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 10/4/2026 11:15:00 AM to Pearl District, San Antonio, TX (USA) arriving at 10/6/2026 12:20:00 AM. 50 Economy ticket for $114 per person are available. Travel duration is 38h 5m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	27h 5m	4:05 PM	Indianapolis	Central Bus Station	6:10 PM	San Antonio, TX	Bus Station	Economy	$100	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 10/6/2026 4:05:00 PM to Bus Station, San Antonio, TX (USA) arriving at 10/7/2026 6:10:00 PM. 50 Economy ticket for $100 per person are available. Travel duration is 27h 5m
Greyhound US	28h 55m	8:10 PM	Indianapolis	Central Bus Station	12:05 AM	San Antonio, TX	Bus Station	Economy	$100	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 10/6/2026 8:10:00 PM to Bus Station, San Antonio, TX (USA) arriving at 10/8/2026 12:05:00 AM. 50 Economy ticket for $100 per person are available. Travel duration is 28h 55m
FlixBus	30h 30m	6:35 PM	Indianapolis	Washington / Delaware	12:05 AM	San Antonio, TX	Bus Station	Economy	$104	A Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 10/6/2026 6:35:00 PM to Bus Station, San Antonio, TX (USA) arriving at 10/8/2026 12:05:00 AM. 50 Economy ticket for $104 per person are available. Travel duration is 30h 30m
Greyhound US	25h 30m	4:40 AM	Indianapolis	Central Bus Station	5:10 AM	San Antonio, TX	Bus Station	Economy	$105	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 10/6/2026 4:40:00 AM to Bus Station, San Antonio, TX (USA) arriving at 10/7/2026 5:10:00 AM. 50 Economy ticket for $105 per person are available. Travel duration is 25h 30m
FlixBus	30h 45m	11:25 PM	Indianapolis	Washington / Delaware	5:10 AM	San Antonio, TX	Bus Station	Economy	$108	A Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 10/6/2026 11:25:00 PM to Bus Station, San Antonio, TX (USA) arriving at 10/8/2026 5:10:00 AM. 50 Economy ticket for $108 per person are available. Travel duration is 30h 45m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	49h 15m	8:10 PM	Indianapolis	Central Bus Station	8:25 PM	San Antonio, TX	Pearl District	Economy	$119	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 10/7/2026 8:10:00 PM to Pearl District, San Antonio, TX (USA) arriving at 10/9/2026 8:25:00 PM. 50 Economy ticket for $119 per person are available. Travel duration is 49h 15m
Greyhound US	27h 5m	4:05 PM	Indianapolis	Central Bus Station	6:10 PM	San Antonio, TX	Bus Station	Economy	$120	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 10/7/2026 4:05:00 PM to Bus Station, San Antonio, TX (USA) arriving at 10/8/2026 6:10:00 PM. 50 Economy ticket for $120 per person are available. Travel duration is 27h 5m
FlixBus	46h 0m	11:25 PM	Indianapolis	Washington / Delaware	8:25 PM	San Antonio, TX	Pearl District	Economy	$120	A Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 10/7/2026 11:25:00 PM to Pearl District, San Antonio, TX (USA) arriving at 10/9/2026 8:25:00 PM. 50 Economy ticket for $120 per person are available. Travel duration is 46h 0m
Greyhound US	26h 40m	11:15 AM	Indianapolis	Central Bus Station	12:55 PM	San Antonio, TX	Bus Station	Economy	$123	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 10/7/2026 11:15:00 AM to Bus Station, San Antonio, TX (USA) arriving at 10/8/2026 12:55:00 PM. 50 Economy ticket for $123 per person are available. Travel duration is 26h 40m
FlixBus	32h 25m	4:40 PM	Indianapolis	Washington / Delaware	12:05 AM	San Antonio, TX	Bus Station	Economy	$123	A Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 10/7/2026 4:40:00 PM to Bus Station, San Antonio, TX (USA) arriving at 10/9/2026 12:05:00 AM. 50 Economy ticket for $123 per person are available. Travel duration is 32h 25m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	34h 20m	11:05 AM	Indianapolis	Central Bus Station	8:25 PM	San Antonio, TX	Pearl District	Economy	$128	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 10/8/2026 11:05:00 AM to Pearl District, San Antonio, TX (USA) arriving at 10/9/2026 8:25:00 PM. 50 Economy ticket for $128 per person are available. Travel duration is 34h 20m
Greyhound US	49h 15m	8:10 PM	Indianapolis	Central Bus Station	8:25 PM	San Antonio, TX	Pearl District	Economy	$128	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 10/8/2026 8:10:00 PM to Pearl District, San Antonio, TX (USA) arriving at 10/10/2026 8:25:00 PM. 50 Economy ticket for $128 per person are available. Travel duration is 49h 15m
Greyhound US	27h 5m	4:05 PM	Indianapolis	Central Bus Station	6:10 PM	San Antonio, TX	Bus Station	Economy	$128	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 10/8/2026 4:05:00 PM to Bus Station, San Antonio, TX (USA) arriving at 10/9/2026 6:10:00 PM. 50 Economy ticket for $128 per person are available. Travel duration is 27h 5m
FlixBus	42h 10m	3:15 AM	Indianapolis	Washington / Delaware	8:25 PM	San Antonio, TX	Pearl District	Economy	$131	A Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 10/8/2026 3:15:00 AM to Pearl District, San Antonio, TX (USA) arriving at 10/9/2026 8:25:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 42h 10m
FlixBus	50h 50m	6:35 PM	Indianapolis	Washington / Delaware	8:25 PM	San Antonio, TX	Pearl District	Economy	$131	A Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 10/8/2026 6:35:00 PM to Pearl District, San Antonio, TX (USA) arriving at 10/10/2026 8:25:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 50h 50m

Did you know that if you travel from Indianapolis to San Antonio, TX via Austin, you can save more than $15? You can find the corresponding connections below.
- Greyhound US
  
  30h 0m
  
  0
  
  11:15 AM
  
  Indianapolis
  Central Bus Station
  
  11:00 AM
  
  Austin
  5119 Eastside Bus Plaza
  
  0
  
  Economy
  
  $102
  
  A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 10/5/2026 11:15:00 AM to 5119 Eastside Bus Plaza, Austin (USA) arriving at 10/6/2026 11:00:00 AM. 50 Economy ticket for $102 per person are available. Travel duration is 24h 45m
- FlixBus
  
  2h 15m
  
  0
  
  2:00 PM
  
  Austin
  RedCoach Stop
  
  4:15 PM
  
  San Antonio, TX
  Pearl District
  
  0
  
  Economy
  
  $11
  
  A Bus from FlixBus goes from RedCoach Stop, Austin (USA) at 10/6/2026 2:00:00 PM to Pearl District, San Antonio, TX (USA) arriving at 10/6/2026 4:15:00 PM. 50 Economy ticket for $11 per person are available. Travel duration is 2h 15m
Travel time is 3h 55m longer, but you will save $15

Best Price Offer: The price for the cheapest bus from Indianapolis to San Antonio, TX is $100 on 10/6/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Indianapolis and San Antonio, TX

See here how frequent the connections between Indianapolis and San Antonio, TX are, during different times and days of the week.

Thursday is the busiest day, with more than 14 daily buses from Indianapolis to San Antonio, TX. Sunday has instead the fewest connections, with only 5 daily coaches between Indianapolis and San Antonio, TX.

The busiest time of the day is the Evening, with 15 buses from Indianapolis to San Antonio, TX, while Night sees the fewest connections between Indianapolis and San Antonio, TX, with 4 offers.

Facts about the bus from Indianapolis to San Antonio, TX

Compare all providers like Greyhound US and FlixBus that travel 9 times every day by bus from Indianapolis to San Antonio, TX in one click! Book your bus ticket from Indianapolis to San Antonio, TX starting from $100!

Cheapest Bus	$100
Fastest Bus	24h 30m
Earliest Bus	11:05 AM
Latest Bus	8:10 PM
Daily Bus Routes	9 Ø
Distance	999.5 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from Indianapolis to San Antonio, TX

Every day, 9 buses from 2 bus companies leave Indianapolis for San Antonio, TX: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 10/04/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 10/04

$103

Monday 10/05

Tuesday 10/06

$100

Wednesday 10/07

$119

Thursday 10/08

$127

Friday 10/09

Saturday 10/10

Sunday 10/11

$121

Monday 10/12

$121

Tuesday 10/13

$111

Wednesday 10/14

$121

Thursday 10/15

$110

Friday 10/16

$124

Saturday 10/17

Sunday 10/18

$108

Monday 10/19

Tuesday 10/20

Wednesday 10/21

$123

Thursday 10/22

$132

Friday 10/23

$124

Saturday 10/24

$123

Sunday 10/25

$121

Monday 10/26

$127

Tuesday 10/27

$132

Wednesday 10/28

Thursday 10/29

$123

Friday 10/30

$118

Saturday 10/31

The cheapest time to travel from Indianapolis to San Antonio, TX

See here on which day and which time of the day you can find the cheapest bus ticket from Indianapolis to San Antonio, TX, for the next 30 days.

With a price starting from $100, Tuesday is the cheapest day for a bus from Indianapolis to San Antonio, TX. Wednesday instead is the most expensive day with prices starting from $119.

Afternoon is the cheapest day time for bus tickets from Indianapolis to San Antonio, TX, with $100. Morning is the most expensive time of the day with prices starting from $105.

How to save money travelling from Indianapolis to San Antonio, TX

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Indianapolis to San Antonio, TX in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Indianapolis to San Antonio, TX, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Indianapolis to San Antonio, TX are also emptier.

All bus stations and stops in Indianapolis and San Antonio, TX

In the map below, you can see where to find all bus stations in Indianapolis and San Antonio, TX.

Mile Square

Monument Circle 2250

Washington / Delaware

E Washington St between N Delaware St and N Alabama St

Central Bus Station

Greyhound Bus Station

S Illinois St 350

S Keystone Avenue

S Keystone Avenue 3649

Bus Station

N St Mary's St 500

San Antonio

Pearl District

Avenue A 699-599

Commerce & Bowie Bus Stop

W. Southcross & Buffalo Bus Stop

Service and Comfort on the bus from Indianapolis to San Antonio, TX

Want to know which seat classes are available on the buses from Indianapolis to San Antonio, TX? Or which bus companies serve the route Indianapolis to San Antonio, TX? Below you will find answers to your questions.

FAQs about the Indianapolis to San Antonio, TX bus

How much does a Indianapolis San Antonio, TX bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $100 and takes 26h 5m to reach San Antonio, TX. Compare offers to save money!

How much could I save by comparing buses from Indianapolis to San Antonio, TX?

This route is offered by 2 companies with a range of ticket prices between $100 and $138. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to San Antonio, TX.

On average, how many connections are available from Indianapolis to San Antonio, TX each day?

Every day, the Indianapolis to San Antonio, TX bus route is served by approximately 9 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Indianapolis to San Antonio, TX take?

The fastest bus from Indianapolis to San Antonio, TX is offered by Greyhound US and takes 24h 30m. Bus tickets for this connection cost $109. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Indianapolis to San Antonio, TX?

The earliest bus arriving in San Antonio, TX from Indianapolis starts at 11:05 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Indianapolis to San Antonio, TX?

The latest bus trip departing from Indianapolis for San Antonio, TX starts at 8:10 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Indianapolis San Antonio, TX route?

When traveling by bus from Indianapolis to San Antonio, TX, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Indianapolis and San Antonio, TX?

You can check all the direct connections between Indianapolis and San Antonio, TX by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Indianapolis to San Antonio, TX bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Indianapolis San Antonio, TX bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Indianapolis San Antonio, TX bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Indianapolis to San Antonio, TX on your planned travel date.

How does CheckMyBus find the best bus deals from Indianapolis to San Antonio, TX?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 9 daily trips between Indianapolis and San Antonio, TX. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Indianapolis to San Antonio, TX?

Prices and availability for 9 trips between Indianapolis and San Antonio, TX change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Indianapolis to San Antonio, TX

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Indianapolis and to San Antonio, TX

Here’s an overview of the most popular bus routes to Indianapolis and to San Antonio, TX. Simply click on the connection of your choice, and you will find all the details about your bus route!