Bus Jefferson City, MO to Chicago: Compare prices and save money

Compare all timetables for the bus from Jefferson City, MO to Chicago

Here is a selection of the cheapest bus trips from the schedule from Jefferson City, MO to Chicago from various bus operators like Greyhound US for the next days.

today

tomorrow

$98

Sunday

$72

Monday

Tuesday

$99

Wednesday

$93

Thursday

$64

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	10h 5m	7:15 PM	Jefferson City, MO	Bus Stop	5:20 AM	Chicago	95th Red Line Station	Economy	$98	A Bus from Greyhound US goes from Bus Stop, Jefferson City, MO (USA) at 2/7/2026 7:15:00 PM to 95th Red Line Station, Chicago (USA) arriving at 2/8/2026 5:20:00 AM. 50 Economy ticket for $98 per person are available. Travel duration is 10h 5m
Greyhound US	18h 55m	7:15 PM	Jefferson City, MO	Bus Stop	2:10 PM	Chicago	Union Station	Economy	$102	A Bus from Greyhound US goes from Bus Stop, Jefferson City, MO (USA) at 2/7/2026 7:15:00 PM to Union Station, Chicago (USA) arriving at 2/8/2026 2:10:00 PM. 50 Economy ticket for $102 per person are available. Travel duration is 18h 55m
Greyhound US	10h 30m	7:15 PM	Jefferson City, MO	Bus Stop	5:45 AM	Chicago	Downtown Bus Station	Economy	$102	A Bus from Greyhound US goes from Bus Stop, Jefferson City, MO (USA) at 2/7/2026 7:15:00 PM to Downtown Bus Station, Chicago (USA) arriving at 2/8/2026 5:45:00 AM. 50 Economy ticket for $102 per person are available. Travel duration is 10h 30m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	10h 30m	7:15 PM	Jefferson City, MO	Bus Stop	5:45 AM	Chicago	Downtown Bus Station	Economy	$72	A Bus from Greyhound US goes from Bus Stop, Jefferson City, MO (USA) at 2/8/2026 7:15:00 PM to Downtown Bus Station, Chicago (USA) arriving at 2/9/2026 5:45:00 AM. 50 Economy ticket for $72 per person are available. Travel duration is 10h 30m
Greyhound US	10h 5m	7:15 PM	Jefferson City, MO	Bus Stop	5:20 AM	Chicago	95th Red Line Station	Economy	$72	A Bus from Greyhound US goes from Bus Stop, Jefferson City, MO (USA) at 2/8/2026 7:15:00 PM to 95th Red Line Station, Chicago (USA) arriving at 2/9/2026 5:20:00 AM. 50 Economy ticket for $72 per person are available. Travel duration is 10h 5m
Greyhound US	18h 55m	7:15 PM	Jefferson City, MO	Bus Stop	2:10 PM	Chicago	Canal & Van Buren	Economy	$73	A Bus from Greyhound US goes from Bus Stop, Jefferson City, MO (USA) at 2/8/2026 7:15:00 PM to Canal & Van Buren, Chicago (USA) arriving at 2/9/2026 2:10:00 PM. 50 Economy ticket for $73 per person are available. Travel duration is 18h 55m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	18h 55m	7:15 PM	Jefferson City, MO	Bus Stop	2:10 PM	Chicago	Canal & Van Buren	Economy	$99	A Bus from Greyhound US goes from Bus Stop, Jefferson City, MO (USA) at 2/10/2026 7:15:00 PM to Canal & Van Buren, Chicago (USA) arriving at 2/11/2026 2:10:00 PM. 50 Economy ticket for $99 per person are available. Travel duration is 18h 55m
Greyhound US	19h 20m	7:15 PM	Jefferson City, MO	Bus Stop	2:35 PM	Chicago	Downtown Bus Station	Economy	$99	A Bus from Greyhound US goes from Bus Stop, Jefferson City, MO (USA) at 2/10/2026 7:15:00 PM to Downtown Bus Station, Chicago (USA) arriving at 2/11/2026 2:35:00 PM. 50 Economy ticket for $99 per person are available. Travel duration is 19h 20m
Greyhound US	18h 25m	7:15 PM	Jefferson City, MO	Bus Stop	1:40 PM	Chicago	95th Red Line Station	Economy	$103	A Bus from Greyhound US goes from Bus Stop, Jefferson City, MO (USA) at 2/10/2026 7:15:00 PM to 95th Red Line Station, Chicago (USA) arriving at 2/11/2026 1:40:00 PM. 50 Economy ticket for $103 per person are available. Travel duration is 18h 25m

Cheapest bus trips Wednesday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	18h 55m	7:15 PM	Jefferson City, MO	Bus Stop	2:10 PM	Chicago	Union Station		Economy	$93	A Bus from Greyhound US goes from Bus Stop, Jefferson City, MO (USA) at 2/11/2026 7:15:00 PM to Union Station, Chicago (USA) arriving at 2/12/2026 2:10:00 PM. 50 Economy ticket for $93 per person are available. Travel duration is 18h 55m
	Greyhound US	19h 20m	7:15 PM	Jefferson City, MO	Bus Stop	2:35 PM	Chicago	Downtown Bus Station		Economy	$93	A Bus from Greyhound US goes from Bus Stop, Jefferson City, MO (USA) at 2/11/2026 7:15:00 PM to Downtown Bus Station, Chicago (USA) arriving at 2/12/2026 2:35:00 PM. 50 Economy ticket for $93 per person are available. Travel duration is 19h 20m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	10h 30m	7:15 PM	Jefferson City, MO	Bus Stop	5:45 AM	Chicago	Downtown Bus Station	Economy	$64	A Bus from Greyhound US goes from Bus Stop, Jefferson City, MO (USA) at 2/12/2026 7:15:00 PM to Downtown Bus Station, Chicago (USA) arriving at 2/13/2026 5:45:00 AM. 50 Economy ticket for $64 per person are available. Travel duration is 10h 30m
Greyhound US	10h 5m	7:15 PM	Jefferson City, MO	Bus Stop	5:20 AM	Chicago	95th Red Line Station	Economy	$68	A Bus from Greyhound US goes from Bus Stop, Jefferson City, MO (USA) at 2/12/2026 7:15:00 PM to 95th Red Line Station, Chicago (USA) arriving at 2/13/2026 5:20:00 AM. 50 Economy ticket for $68 per person are available. Travel duration is 10h 5m
Greyhound US	18h 55m	7:15 PM	Jefferson City, MO	Bus Stop	2:10 PM	Chicago	Canal & Van Buren	Economy	$88	A Bus from Greyhound US goes from Bus Stop, Jefferson City, MO (USA) at 2/12/2026 7:15:00 PM to Canal & Van Buren, Chicago (USA) arriving at 2/13/2026 2:10:00 PM. 50 Economy ticket for $88 per person are available. Travel duration is 18h 55m

Best Price Offer: The price for the cheapest bus from Jefferson City, MO to Chicago is $60 on 2/2/2026. Flexible travelers save on ticket prices.

Facts about the bus from Jefferson City, MO to Chicago

Compare all providers like Greyhound US that travel 3 times every day by bus from Jefferson City, MO to Chicago in one click! Book your bus ticket from Jefferson City, MO to Chicago starting from $60!

Cheapest Bus	$60
Fastest Bus	10h 5m
Earliest Bus	7:15 PM
Latest Bus	7:15 PM
Daily Bus Routes	3 Ø
Distance	330.5 miles
Bus Companies	Greyhound US

Cheapest bus connections from Jefferson City, MO to Chicago

Every day, 3 buses from 1 bus companies leave Jefferson City, MO for Chicago: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 02/06/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 02/01

Monday 02/02

Tuesday 02/03

Wednesday 02/04

Thursday 02/05

Friday 02/06

Saturday 02/07

$102

Sunday 02/08

$72

Monday 02/09

Tuesday 02/10

$99

Wednesday 02/11

$93

Thursday 02/12

$64

Friday 02/13

$64

Saturday 02/14

Sunday 02/15

Monday 02/16

Tuesday 02/17

Wednesday 02/18

Thursday 02/19

Friday 02/20

Saturday 02/21

Sunday 02/22

Monday 02/23

Tuesday 02/24

Wednesday 02/25

Thursday 02/26

Friday 02/27

Saturday 02/28

How to save money travelling from Jefferson City, MO to Chicago

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Jefferson City, MO to Chicago in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Jefferson City, MO to Chicago, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Jefferson City, MO to Chicago are also emptier.

All bus stations and stops in Jefferson City, MO and Chicago

In the map below, you can see where to find all bus stations in Jefferson City, MO and Chicago.

Bus Stop

Eastland 701

Jefferson St. @ McCarty St.

95th Red Line Station

W. 95th St 14

Downtown Bus Station

West Harrison Street 630-670

Union Station

S Canal St 225

Cumberland CTA

N Cumberland Ave 5800

Canal & Van Buren

S Canal St 310-320

Service and Comfort on the bus from Jefferson City, MO to Chicago

Want to know which seat classes are available on the buses from Jefferson City, MO to Chicago? Or which bus companies serve the route Jefferson City, MO to Chicago? Below you will find answers to your questions.

FAQs about the Jefferson City, MO to Chicago bus

How much does a Jefferson City, MO Chicago bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $60 and takes 10h 30m to reach Chicago. Compare offers to save money!

How much could I save by comparing buses from Jefferson City, MO to Chicago?

This route is offered by 1 companies with a range of ticket prices between $60 and $107. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Chicago.

On average, how many connections are available from Jefferson City, MO to Chicago each day?

Every day, the Jefferson City, MO to Chicago bus route is served by approximately 3 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Jefferson City, MO to Chicago take?

The fastest bus from Jefferson City, MO to Chicago is offered by Greyhound US and takes 10h 5m. Bus tickets for this connection cost $98. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Jefferson City, MO to Chicago?

The earliest bus arriving in Chicago from Jefferson City, MO starts at 7:15 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Jefferson City, MO to Chicago?

The latest bus trip departing from Jefferson City, MO for Chicago starts at 7:15 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Jefferson City, MO Chicago route?

When traveling by bus from Jefferson City, MO to Chicago, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Jefferson City, MO and Chicago?

You can check all the direct connections between Jefferson City, MO and Chicago by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Jefferson City, MO to Chicago bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Jefferson City, MO Chicago bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Jefferson City, MO Chicago bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Jefferson City, MO to Chicago on your planned travel date.

How does CheckMyBus find the best bus deals from Jefferson City, MO to Chicago?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 3 daily trips between Jefferson City, MO and Chicago. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Jefferson City, MO to Chicago?

Prices and availability for 3 trips between Jefferson City, MO and Chicago change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Jefferson City, MO to Chicago

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Jefferson City, MO and to Chicago

Here’s an overview of the most popular bus routes to Jefferson City, MO and to Chicago. Simply click on the connection of your choice, and you will find all the details about your bus route!