Bus Roanoke, VA to Indianapolis: Compare prices and save money

Compare all timetables for the bus from Roanoke, VA to Indianapolis

Here is a selection of the cheapest bus trips from the schedule from Roanoke, VA to Indianapolis from various bus operators like Greyhound US for the next days.

today

tomorrow

$139

Sunday

$111

Monday

$133

Tuesday

Wednesday

Thursday

$135

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	15h 55m	12:50 PM	Roanoke, VA	Greyhound	4:45 AM	Indianapolis	Central Bus Station	Economy	$139	A Bus from Greyhound US goes from Greyhound, Roanoke, VA (USA) at 12/6/2025 12:50:00 PM to Central Bus Station, Indianapolis (USA) arriving at 12/7/2025 4:45:00 AM. 50 Economy ticket for $139 per person are available. Travel duration is 15h 55m
Greyhound US	22h 25m	4:35 AM	Roanoke, VA	Greyhound	3:00 AM	Indianapolis	Washington / Delaware	Economy	$140	A Bus from Greyhound US goes from Greyhound, Roanoke, VA (USA) at 12/6/2025 4:35:00 AM to Washington / Delaware, Indianapolis (USA) arriving at 12/7/2025 3:00:00 AM. 50 Economy ticket for $140 per person are available. Travel duration is 22h 25m
Greyhound US	21h 40m	4:35 AM	Roanoke, VA	Greyhound	2:15 AM	Indianapolis	Central Bus Station	Economy	$140	A Bus from Greyhound US goes from Greyhound, Roanoke, VA (USA) at 12/6/2025 4:35:00 AM to Central Bus Station, Indianapolis (USA) arriving at 12/7/2025 2:15:00 AM. 50 Economy ticket for $140 per person are available. Travel duration is 21h 40m
Greyhound US	19h 35m	12:50 PM	Roanoke, VA	Greyhound	8:25 AM	Indianapolis	Washington / Delaware	Economy	$141	A Bus from Greyhound US goes from Greyhound, Roanoke, VA (USA) at 12/6/2025 12:50:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 12/7/2025 8:25:00 AM. 50 Economy ticket for $141 per person are available. Travel duration is 19h 35m

Did you know that if you travel from Roanoke, VA to Indianapolis via Nashville, you can save more than $39? You can find the corresponding connections below.
- FlixBus
  
  15h 55m
  
  0
  
  12:50 PM
  
  Roanoke, VA
  Greyhound
  
  7:55 PM
  
  Nashville
  5th Ave South Station
  
  0
  
  Economy
  
  $59
  
  A Bus from FlixBus goes from Greyhound, Roanoke, VA (USA) at 12/6/2025 12:50:00 PM to 5th Ave South Station, Nashville (USA) arriving at 12/6/2025 7:55:00 PM. 50 Economy ticket for $59 per person are available. Travel duration is 8h 5m
- Busbud
  
  5h 30m
  
  0
  
  10:15 PM
  
  Nashville
  5th Ave South Station
  
  4:45 AM
  
  Indianapolis
  Central Bus Station
  
  0
  
  Economy
  
  $41
  
  A Bus from Busbud goes from 5th Ave South Station, Nashville (USA) at 12/6/2025 10:15:00 PM to Central Bus Station, Indianapolis (USA) arriving at 12/7/2025 4:45:00 AM. 50 Economy ticket for $41 per person are available. Travel duration is 5h 30m
Travel time is the same as the direct connection, but you will save $39

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	19h 35m	12:50 PM	Roanoke, VA	Greyhound	8:25 AM	Indianapolis	Downtown Transit Center	Economy	$111	A Bus from Greyhound US goes from Greyhound, Roanoke, VA (USA) at 12/7/2025 12:50:00 PM to Downtown Transit Center, Indianapolis (USA) arriving at 12/8/2025 8:25:00 AM. 50 Economy ticket for $111 per person are available. Travel duration is 19h 35m
Greyhound US	22h 25m	4:35 AM	Roanoke, VA	Greyhound	3:00 AM	Indianapolis	Downtown Transit Center	Economy	$113	A Bus from Greyhound US goes from Greyhound, Roanoke, VA (USA) at 12/7/2025 4:35:00 AM to Downtown Transit Center, Indianapolis (USA) arriving at 12/8/2025 3:00:00 AM. 50 Economy ticket for $113 per person are available. Travel duration is 22h 25m
Greyhound US	21h 40m	4:35 AM	Roanoke, VA	Greyhound	2:15 AM	Indianapolis	Central Bus Station	Economy	$113	A Bus from Greyhound US goes from Greyhound, Roanoke, VA (USA) at 12/7/2025 4:35:00 AM to Central Bus Station, Indianapolis (USA) arriving at 12/8/2025 2:15:00 AM. 50 Economy ticket for $113 per person are available. Travel duration is 21h 40m
Greyhound US	15h 55m	12:50 PM	Roanoke, VA	Greyhound	4:45 AM	Indianapolis	Central Bus Station	Economy	$113	A Bus from Greyhound US goes from Greyhound, Roanoke, VA (USA) at 12/7/2025 12:50:00 PM to Central Bus Station, Indianapolis (USA) arriving at 12/8/2025 4:45:00 AM. 50 Economy ticket for $113 per person are available. Travel duration is 15h 55m

Did you know that if you travel from Roanoke, VA to Indianapolis via Nashville, you can save more than $18? You can find the corresponding connections below.
- FlixBus
  
  15h 55m
  
  0
  
  12:50 PM
  
  Roanoke, VA
  Greyhound
  
  7:55 PM
  
  Nashville
  5th Ave South Station
  
  0
  
  Economy
  
  $55
  
  A Bus from FlixBus goes from Greyhound, Roanoke, VA (USA) at 12/8/2025 12:50:00 PM to 5th Ave South Station, Nashville (USA) arriving at 12/8/2025 7:55:00 PM. 50 Economy ticket for $55 per person are available. Travel duration is 8h 5m
- Busbud
  
  5h 30m
  
  0
  
  10:15 PM
  
  Nashville
  5th Ave South Station
  
  4:45 AM
  
  Indianapolis
  Central Bus Station
  
  0
  
  Economy
  
  $38
  
  A Bus from Busbud goes from 5th Ave South Station, Nashville (USA) at 12/8/2025 10:15:00 PM to Central Bus Station, Indianapolis (USA) arriving at 12/9/2025 4:45:00 AM. 50 Economy ticket for $38 per person are available. Travel duration is 5h 30m
Travel time is the same as the direct connection, but you will save $18

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	19h 35m	12:50 PM	Roanoke, VA	Greyhound	8:25 AM	Indianapolis	Washington / Delaware	Economy	$133	A Bus from Greyhound US goes from Greyhound, Roanoke, VA (USA) at 12/8/2025 12:50:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 12/9/2025 8:25:00 AM. 50 Economy ticket for $133 per person are available. Travel duration is 19h 35m
Greyhound US	15h 55m	12:50 PM	Roanoke, VA	Greyhound	4:45 AM	Indianapolis	Central Bus Station	Economy	$135	A Bus from Greyhound US goes from Greyhound, Roanoke, VA (USA) at 12/8/2025 12:50:00 PM to Central Bus Station, Indianapolis (USA) arriving at 12/9/2025 4:45:00 AM. 50 Economy ticket for $135 per person are available. Travel duration is 15h 55m
Greyhound US	21h 40m	4:35 AM	Roanoke, VA	Greyhound	2:15 AM	Indianapolis	Central Bus Station	Economy	$147	A Bus from Greyhound US goes from Greyhound, Roanoke, VA (USA) at 12/8/2025 4:35:00 AM to Central Bus Station, Indianapolis (USA) arriving at 12/9/2025 2:15:00 AM. 50 Economy ticket for $147 per person are available. Travel duration is 21h 40m

Did you know that if you travel from Roanoke, VA to Indianapolis via Nashville, you can save more than $40? You can find the corresponding connections below.
- FlixBus
  
  15h 55m
  
  0
  
  12:50 PM
  
  Roanoke, VA
  Greyhound
  
  7:55 PM
  
  Nashville
  5th Ave South Station
  
  0
  
  Economy
  
  $55
  
  A Bus from FlixBus goes from Greyhound, Roanoke, VA (USA) at 12/8/2025 12:50:00 PM to 5th Ave South Station, Nashville (USA) arriving at 12/8/2025 7:55:00 PM. 50 Economy ticket for $55 per person are available. Travel duration is 8h 5m
- Busbud
  
  5h 30m
  
  0
  
  10:15 PM
  
  Nashville
  5th Ave South Station
  
  4:45 AM
  
  Indianapolis
  Central Bus Station
  
  0
  
  Economy
  
  $38
  
  A Bus from Busbud goes from 5th Ave South Station, Nashville (USA) at 12/8/2025 10:15:00 PM to Central Bus Station, Indianapolis (USA) arriving at 12/9/2025 4:45:00 AM. 50 Economy ticket for $38 per person are available. Travel duration is 5h 30m
Travel time is the same as the direct connection, but you will save $40

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	19h 35m	12:50 PM	Roanoke, VA	Greyhound	8:25 AM	Indianapolis	Washington / Delaware	Economy	$135	A Bus from Greyhound US goes from Greyhound, Roanoke, VA (USA) at 12/11/2025 12:50:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 12/12/2025 8:25:00 AM. 50 Economy ticket for $135 per person are available. Travel duration is 19h 35m
Greyhound US	15h 55m	12:50 PM	Roanoke, VA	Greyhound	4:45 AM	Indianapolis	Central Bus Station	Economy	$135	A Bus from Greyhound US goes from Greyhound, Roanoke, VA (USA) at 12/11/2025 12:50:00 PM to Central Bus Station, Indianapolis (USA) arriving at 12/12/2025 4:45:00 AM. 50 Economy ticket for $135 per person are available. Travel duration is 15h 55m
Greyhound US	22h 25m	4:35 AM	Roanoke, VA	Greyhound	3:00 AM	Indianapolis	Washington / Delaware	Economy	$137	A Bus from Greyhound US goes from Greyhound, Roanoke, VA (USA) at 12/11/2025 4:35:00 AM to Washington / Delaware, Indianapolis (USA) arriving at 12/12/2025 3:00:00 AM. 50 Economy ticket for $137 per person are available. Travel duration is 22h 25m
Greyhound US	23h 25m	4:35 AM	Roanoke, VA	Greyhound	4:00 AM	Indianapolis	Central Bus Station	Economy	$137	A Bus from Greyhound US goes from Greyhound, Roanoke, VA (USA) at 12/11/2025 4:35:00 AM to Central Bus Station, Indianapolis (USA) arriving at 12/12/2025 4:00:00 AM. 50 Economy ticket for $137 per person are available. Travel duration is 23h 25m

Did you know that if you travel from Roanoke, VA to Indianapolis via Nashville, you can save more than $42? You can find the corresponding connections below.
- FlixBus
  
  15h 55m
  
  0
  
  12:50 PM
  
  Roanoke, VA
  Greyhound
  
  7:55 PM
  
  Nashville
  5th Ave South Station
  
  0
  
  Economy
  
  $55
  
  A Bus from FlixBus goes from Greyhound, Roanoke, VA (USA) at 12/8/2025 12:50:00 PM to 5th Ave South Station, Nashville (USA) arriving at 12/8/2025 7:55:00 PM. 50 Economy ticket for $55 per person are available. Travel duration is 8h 5m
- Busbud
  
  5h 30m
  
  0
  
  10:15 PM
  
  Nashville
  5th Ave South Station
  
  4:45 AM
  
  Indianapolis
  Central Bus Station
  
  0
  
  Economy
  
  $38
  
  A Bus from Busbud goes from 5th Ave South Station, Nashville (USA) at 12/8/2025 10:15:00 PM to Central Bus Station, Indianapolis (USA) arriving at 12/9/2025 4:45:00 AM. 50 Economy ticket for $38 per person are available. Travel duration is 5h 30m
Travel time is the same as the direct connection, but you will save $42

Best Price Offer: The price for the cheapest bus from Roanoke, VA to Indianapolis is $111 on 12/7/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between Roanoke, VA and Indianapolis

See here how frequent the connections between Roanoke, VA and Indianapolis are, during different times and days of the week.

Sunday is the busiest day, with more than 8 daily buses from Roanoke, VA to Indianapolis. Monday has instead the fewest connections, with only 3 daily coaches between Roanoke, VA and Indianapolis.

The busiest time of the day is the Afternoon, with 10 buses from Roanoke, VA to Indianapolis, while Night sees the fewest connections between Roanoke, VA and Indianapolis, with 9 offers.

Facts about the bus from Roanoke, VA to Indianapolis

Compare all providers like Greyhound US that travel 4 times every day by bus from Roanoke, VA to Indianapolis in one click! Book your bus ticket from Roanoke, VA to Indianapolis starting from $111!

Cheapest Bus	$111
Fastest Bus	15h 55m
Earliest Bus	4:35 AM
Latest Bus	12:50 PM
Daily Bus Routes	4 Ø
Distance	377.5 miles
Bus Companies	Greyhound US

Cheapest bus connections from Roanoke, VA to Indianapolis

Every day, 4 buses from 1 bus companies leave Roanoke, VA for Indianapolis: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/05/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 11/30

Monday 12/01

Tuesday 12/02

Wednesday 12/03

Thursday 12/04

Friday 12/05

Saturday 12/06

$139

Sunday 12/07

$111

Monday 12/08

$133

Tuesday 12/09

Wednesday 12/10

Thursday 12/11

$135

Friday 12/12

Saturday 12/13

Sunday 12/14

Monday 12/15

Tuesday 12/16

Wednesday 12/17

Thursday 12/18

Friday 12/19

Saturday 12/20

$176

Sunday 12/21

Monday 12/22

$154

Tuesday 12/23

Wednesday 12/24

Thursday 12/25

Friday 12/26

Saturday 12/27

The cheapest time to travel from Roanoke, VA to Indianapolis

See here on which day and which time of the day you can find the cheapest bus ticket from Roanoke, VA to Indianapolis, for the next 30 days.

With a price starting from $111, Sunday is the cheapest day for a bus from Roanoke, VA to Indianapolis. Saturday instead is the most expensive day with prices starting from $139.

Afternoon is the cheapest day time for bus tickets from Roanoke, VA to Indianapolis, with $111. Afternoon is the most expensive time of the day with prices starting from $111.

How to save money travelling from Roanoke, VA to Indianapolis

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Roanoke, VA to Indianapolis in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Roanoke, VA to Indianapolis, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Roanoke, VA to Indianapolis are also emptier.

All bus stations and stops in Roanoke, VA and Indianapolis

In the map below, you can see where to find all bus stations in Roanoke, VA and Indianapolis.

Greyhound

Salem Ave Sw 26

Park and Ride

Hollins Shell Gas Station

Planation Rd. 8040

Mile Square

Monument Circle 2250

Washington / Delaware

E Washington St between N Delaware St and N Alabama St

Central Bus Station

Greyhound Bus Station

S Illinois St 350

S Keystone Avenue

S Keystone Avenue 3649

Service and Comfort on the bus from Roanoke, VA to Indianapolis

Want to know which seat classes are available on the buses from Roanoke, VA to Indianapolis? Or which bus companies serve the route Roanoke, VA to Indianapolis? Below you will find answers to your questions.

FAQs about the Roanoke, VA to Indianapolis bus

How much does a Roanoke, VA Indianapolis bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $111 and takes 19h 35m to reach Indianapolis. Compare offers to save money!

How much could I save by comparing buses from Roanoke, VA to Indianapolis?

This route is offered by 1 companies with a range of ticket prices between $111 and $147. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Indianapolis.

On average, how many connections are available from Roanoke, VA to Indianapolis each day?

Every day, the Roanoke, VA to Indianapolis bus route is served by approximately 4 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Roanoke, VA to Indianapolis take?

The fastest bus from Roanoke, VA to Indianapolis is offered by Greyhound US and takes 15h 55m. Bus tickets for this connection cost $139. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Roanoke, VA to Indianapolis?

The earliest bus arriving in Indianapolis from Roanoke, VA starts at 4:35 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Roanoke, VA to Indianapolis?

The latest bus trip departing from Roanoke, VA for Indianapolis starts at 12:50 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Roanoke, VA Indianapolis route?

When traveling by bus from Roanoke, VA to Indianapolis, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Roanoke, VA and Indianapolis?

You can check all the direct connections between Roanoke, VA and Indianapolis by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Roanoke, VA to Indianapolis bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Roanoke, VA Indianapolis bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Roanoke, VA Indianapolis bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Roanoke, VA to Indianapolis on your planned travel date.

Available seat classes which are offered on the bus route Roanoke, VA to Indianapolis

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Roanoke, VA and to Indianapolis

Here’s an overview of the most popular bus routes to Roanoke, VA and to Indianapolis. Simply click on the connection of your choice, and you will find all the details about your bus route!