What is the best way to travel from Brussels to Prague?
Looking for a trip? Compare all the available Flights and Buses for the journey to Prague from Brussels. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
What is the cheapest way to reach Prague from Brussels?
You can get to Prague with just $26 by taking a Flight from Ryanair, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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Ryanair1h 30m012:10 PMBrussels South Charleroi AirportBrussels South Charleroi Airport1:40 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Ryanair goes from Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) at 6/2/2026 12:10:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/2/2026 1:40:00 PM. 50 Economy ticket for $26 per person are available. Travel duration is 1h 30m
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Ryanair1h 30m07:55 AMBrussels South Charleroi AirportBrussels South Charleroi Airport9:25 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Ryanair goes from Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) at 6/2/2026 7:55:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/2/2026 9:25:00 AM. 50 Economy ticket for $29 per person are available. Travel duration is 1h 30m
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Brussels Airlines1h 25m04:30 PMBrussels AirportBrussels Airport5:55 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Brussels Airlines goes from Brussels Airport, Brussels Airport (Belgium) at 6/2/2026 4:30:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/2/2026 5:55:00 PM. 50 Economy ticket for $136 per person are available. Travel duration is 1h 25m
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Brussels Airlines1h 25m09:00 PMBrussels AirportBrussels Airport10:25 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Brussels Airlines goes from Brussels Airport, Brussels Airport (Belgium) at 6/2/2026 9:00:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/2/2026 10:25:00 PM. 50 Economy ticket for $136 per person are available. Travel duration is 1h 25m
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Jetairfly18h 25m02:30 PMAntwerp AirportAntwerp Airport8:55 AMPrague AirportPrague Airport0EconomyA Flight from Jetairfly goes from Antwerp Airport, Antwerp Airport (Belgium) at 6/2/2026 2:30:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 6/3/2026 8:55:00 AM. 50 Economy ticket for $304 per person are available. Travel duration is 18h 25m
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FlixBus23h 25m09:45 AMBrussels AirportBrussels Airport9:10 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Brussels Airport, Brussels Airport (Belgium) at 6/2/2026 9:45:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 6/3/2026 9:10:00 AM. 50 Economy ticket for $57 per person are available. Travel duration is 23h 25m
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FlixBus21h 10m09:30 PMBrussels AirportBrussels Airport6:40 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Brussels Airport, Brussels Airport (Belgium) at 6/2/2026 9:30:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 6/3/2026 6:40:00 PM. 50 Economy ticket for $57 per person are available. Travel duration is 21h 10m
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FlixBus22h 40m02:05 PMBrussels AirportBrussels Airport12:45 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Brussels Airport, Brussels Airport (Belgium) at 6/2/2026 2:05:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 6/3/2026 12:45:00 PM. 50 Economy ticket for $58 per person are available. Travel duration is 22h 40m
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FlixBus22h 45m06:45 PMBrussels AirportBrussels Airport5:30 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Brussels Airport, Brussels Airport (Belgium) at 6/2/2026 6:45:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/3/2026 5:30:00 PM. 50 Economy ticket for $58 per person are available. Travel duration is 22h 45m
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FlixBus24h 55m09:30 PMBrussels AirportBrussels Airport10:25 PMPragueČerný Most0EconomyA Bus from FlixBus goes from Brussels Airport, Brussels Airport (Belgium) at 6/2/2026 9:30:00 PM to Černý Most, Prague (Czech Republic) arriving at 6/3/2026 10:25:00 PM. 50 Economy ticket for $58 per person are available. Travel duration is 24h 55m
Cheapest Flights Tuesday
Cheapest Buses Tuesday
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Ryanair1h 30m07:30 PMBrussels AirportBrussels Airport9:00 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Ryanair goes from Brussels Airport, Brussels Airport (Belgium) at 6/3/2026 7:30:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/3/2026 9:00:00 PM. 50 Economy ticket for $31 per person are available. Travel duration is 1h 30m
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Wizz Air11h 20m08:10 AMBrussels South Charleroi AirportBrussels South Charleroi Airport7:30 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Wizz Air goes from Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) at 6/3/2026 8:10:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/3/2026 7:30:00 PM. 50 Economy ticket for $59 per person are available. Travel duration is 11h 20m
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LC Perú5h 40m09:40 AMBrussels South Charleroi AirportBrussels South Charleroi Airport3:20 PMPrague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) at 6/3/2026 9:40:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/3/2026 3:20:00 PM. 50 Economy ticket for $69 per person are available. Travel duration is 5h 40m
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Buzz5h 30m012:55 PMBrussels South Charleroi AirportBrussels South Charleroi Airport6:25 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Buzz goes from Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) at 6/3/2026 12:55:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/3/2026 6:25:00 PM. 50 Economy ticket for $81 per person are available. Travel duration is 5h 30m
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EasyJet Airline20h 0m09:15 PMBrussels AirportBrussels Airport5:15 PMPrague AirportPrague Airport0EconomyA Flight from EasyJet Airline goes from Brussels Airport, Brussels Airport (Belgium) at 6/3/2026 9:15:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 6/4/2026 5:15:00 PM. 50 Economy ticket for $104 per person are available. Travel duration is 20h 0m
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FlixBus12h 50m09:30 AMBrusselsNorth Station10:20 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 6/3/2026 9:30:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 6/3/2026 10:20:00 PM. 50 Economy ticket for $61 per person are available. Travel duration is 12h 50m
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FlixBus16h 30m09:30 PMBrusselsNorth Station2:00 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 6/3/2026 9:30:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/4/2026 2:00:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 16h 30m
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FlixBus17h 5m010:55 PMBrusselsNorth Station4:00 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 6/3/2026 10:55:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/4/2026 4:00:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 17h 5m
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European Sleeper15h 29m07:22 PMBrusselsMidi Bus Station10:51 AMPragueWilsonova Bus Station0EconomyA Bus from European Sleeper goes from Midi Bus Station, Brussels (Belgium) at 6/3/2026 7:22:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/4/2026 10:51:00 AM. 50 Economy ticket for $349 per person are available. Travel duration is 15h 29m
Cheapest Flights Wednesday
Cheapest Buses Wednesday
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Ryanair1h 30m012:40 PMBrussels South Charleroi AirportBrussels South Charleroi Airport2:10 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Ryanair goes from Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) at 6/4/2026 12:40:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/4/2026 2:10:00 PM. 50 Economy ticket for $29 per person are available. Travel duration is 1h 30m
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Smartwings1h 25m08:55 AMBrussels AirportBrussels Airport10:20 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Smartwings goes from Brussels Airport, Brussels Airport (Belgium) at 6/4/2026 8:55:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/4/2026 10:20:00 AM. 50 Economy ticket for $108 per person are available. Travel duration is 1h 25m
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Smartwings1h 25m08:55 AMBrussels AirportBrussels Airport10:20 AMPrague AirportPrague Airport0EconomyA Flight from Smartwings goes from Brussels Airport, Brussels Airport (Belgium) at 6/4/2026 8:55:00 AM to Prague Airport, Prague Airport (Czech Republic) arriving at 6/4/2026 10:20:00 AM. 50 Economy ticket for $116 per person are available. Travel duration is 1h 25m
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Brussels Airlines1h 25m07:00 PMBrussels AirportBrussels Airport8:25 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Brussels Airlines goes from Brussels Airport, Brussels Airport (Belgium) at 6/4/2026 7:00:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/4/2026 8:25:00 PM. 50 Economy ticket for $137 per person are available. Travel duration is 1h 25m
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Brussels Airlines1h 25m09:00 PMBrussels AirportBrussels Airport10:25 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Brussels Airlines goes from Brussels Airport, Brussels Airport (Belgium) at 6/4/2026 9:00:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/4/2026 10:25:00 PM. 50 Economy ticket for $137 per person are available. Travel duration is 1h 25m
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FlixBus15h 0m010:30 PMBrusselsMidi Bus Station1:30 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 6/4/2026 10:30:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 6/5/2026 1:30:00 PM. 50 Economy ticket for $59 per person are available. Travel duration is 15h 0m
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FlixBus12h 50m09:30 AMBrusselsNorth Station10:20 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 6/4/2026 9:30:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 6/4/2026 10:20:00 PM. 50 Economy ticket for $59 per person are available. Travel duration is 12h 50m
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FlixBus13h 35m010:30 AMBrusselsNorth Station12:05 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 6/4/2026 10:30:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 6/5/2026 12:05:00 AM. 50 Economy ticket for $59 per person are available. Travel duration is 13h 35m
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FlixBus13h 55m010:30 AMBrusselsNorth Station12:25 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 6/4/2026 10:30:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/5/2026 12:25:00 AM. 50 Economy ticket for $59 per person are available. Travel duration is 13h 55m
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FlixBus14h 40m04:15 PMBrusselsMidi Bus Station6:55 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 6/4/2026 4:15:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 6/5/2026 6:55:00 AM. 50 Economy ticket for $63 per person are available. Travel duration is 14h 40m
Cheapest Flights Thursday
Cheapest Buses Thursday
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Ryanair1h 30m07:30 PMBrussels South Charleroi AirportBrussels South Charleroi Airport9:00 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Ryanair goes from Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) at 6/5/2026 7:30:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/5/2026 9:00:00 PM. 50 Economy ticket for $44 per person are available. Travel duration is 1h 30m
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EasyJet Airline10h 45m09:10 PMBrussels AirportBrussels Airport7:55 AMPrague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Brussels Airport, Brussels Airport (Belgium) at 6/5/2026 9:10:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/6/2026 7:55:00 AM. 50 Economy ticket for $89 per person are available. Travel duration is 10h 45m
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Smartwings1h 25m08:55 AMBrussels AirportBrussels Airport10:20 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Smartwings goes from Brussels Airport, Brussels Airport (Belgium) at 6/5/2026 8:55:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/5/2026 10:20:00 AM. 50 Economy ticket for $110 per person are available. Travel duration is 1h 25m
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Brussels Airlines1h 25m04:30 PMBrussels AirportBrussels Airport5:55 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Brussels Airlines goes from Brussels Airport, Brussels Airport (Belgium) at 6/5/2026 4:30:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/5/2026 5:55:00 PM. 50 Economy ticket for $137 per person are available. Travel duration is 1h 25m
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Swiss International Air Lines13h 35m09:40 AMBrussels AirportBrussels Airport11:15 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Swiss International Air Lines goes from Brussels Airport, Brussels Airport (Belgium) at 6/5/2026 9:40:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/5/2026 11:15:00 PM. 50 Economy ticket for $172 per person are available. Travel duration is 13h 35m
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FlixBus15h 0m010:30 PMBrusselsMidi Bus Station1:30 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 6/5/2026 10:30:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 6/6/2026 1:30:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 15h 0m
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FlixBus13h 35m010:30 AMBrusselsNorth Station12:05 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 6/5/2026 10:30:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 6/6/2026 12:05:00 AM. 50 Economy ticket for $64 per person are available. Travel duration is 13h 35m
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FlixBus13h 55m010:30 AMBrusselsNorth Station12:25 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 6/5/2026 10:30:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/6/2026 12:25:00 AM. 50 Economy ticket for $64 per person are available. Travel duration is 13h 55m
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European Sleeper15h 29m07:22 PMBrusselsMidi Bus Station10:51 AMPragueWilsonova Bus Station0EconomyA Bus from European Sleeper goes from Midi Bus Station, Brussels (Belgium) at 6/5/2026 7:22:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/6/2026 10:51:00 AM. 50 Economy ticket for $233 per person are available. Travel duration is 15h 29m
Cheapest Flights Friday
Cheapest Buses Friday
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Buzz1h 30m012:35 PMBrussels South Charleroi AirportBrussels South Charleroi Airport2:05 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Buzz goes from Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) at 6/6/2026 12:35:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/6/2026 2:05:00 PM. 50 Economy ticket for $50 per person are available. Travel duration is 1h 30m
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Ryanair1h 30m012:35 PMBrussels AirportBrussels Airport2:05 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Ryanair goes from Brussels Airport, Brussels Airport (Belgium) at 6/6/2026 12:35:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/6/2026 2:05:00 PM. 50 Economy ticket for $51 per person are available. Travel duration is 1h 30m
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LC Perú6h 0m03:35 PMBrussels South Charleroi AirportBrussels South Charleroi Airport9:35 PMPrague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) at 6/6/2026 3:35:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/6/2026 9:35:00 PM. 50 Economy ticket for $56 per person are available. Travel duration is 6h 0m
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Skyscanner6h 35m07:55 AMBrussels South Charleroi AirportBrussels South Charleroi Airport2:30 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Skyscanner goes from Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) at 6/6/2026 7:55:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/6/2026 2:30:00 PM. 50 Economy ticket for $84 per person are available. Travel duration is 6h 35m
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KLM Cityhopper4h 40m03:10 PMBrussels AirportBrussels Airport7:50 PMPrague AirportPrague Airport - T1/20EconomyA Flight from KLM Cityhopper goes from Brussels Airport, Brussels Airport (Belgium) at 6/6/2026 3:10:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/6/2026 7:50:00 PM. 50 Economy ticket for $146 per person are available. Travel duration is 4h 40m
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FlixBus13h 35m010:30 AMBrusselsNorth Station12:05 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 6/6/2026 10:30:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 6/7/2026 12:05:00 AM. 50 Economy ticket for $63 per person are available. Travel duration is 13h 35m
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FlixBus13h 55m010:30 AMBrusselsNorth Station12:25 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 6/6/2026 10:30:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/7/2026 12:25:00 AM. 50 Economy ticket for $63 per person are available. Travel duration is 13h 55m
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FlixBus17h 50m01:20 AMBrusselsMidi Bus Station7:10 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 6/6/2026 1:20:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 6/6/2026 7:10:00 PM. 50 Economy ticket for $66 per person are available. Travel duration is 17h 50m
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FlixBus17h 50m01:20 AMBrusselsMidi Bus Station7:10 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 6/6/2026 1:20:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 6/6/2026 7:10:00 PM. 50 Economy ticket for $66 per person are available. Travel duration is 17h 50m
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FlixBus17h 55m03:15 AMBrusselsMidi Bus Station9:10 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 6/6/2026 3:15:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 6/6/2026 9:10:00 PM. 50 Economy ticket for $66 per person are available. Travel duration is 17h 55m
Cheapest Flights Saturday
Cheapest Buses Saturday
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Ryanair1h 30m012:25 PMBrussels South Charleroi AirportBrussels South Charleroi Airport1:55 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Ryanair goes from Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) at 6/7/2026 12:25:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/7/2026 1:55:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 1h 30m
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Brussels Airlines1h 25m07:00 PMBrussels AirportBrussels Airport8:25 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Brussels Airlines goes from Brussels Airport, Brussels Airport (Belgium) at 6/7/2026 7:00:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/7/2026 8:25:00 PM. 50 Economy ticket for $135 per person are available. Travel duration is 1h 25m
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Brussels Airlines1h 25m09:00 PMBrussels AirportBrussels Airport10:25 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Brussels Airlines goes from Brussels Airport, Brussels Airport (Belgium) at 6/7/2026 9:00:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/7/2026 10:25:00 PM. 50 Economy ticket for $135 per person are available. Travel duration is 1h 25m
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Smartwings1h 25m07:30 PMBrussels AirportBrussels Airport8:55 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Smartwings goes from Brussels Airport, Brussels Airport (Belgium) at 6/7/2026 7:30:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/7/2026 8:55:00 PM. 50 Economy ticket for $264 per person are available. Travel duration is 1h 25m
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Smartwings1h 25m07:30 PMBrussels AirportBrussels Airport8:55 PMPrague AirportPrague Airport0EconomyA Flight from Smartwings goes from Brussels Airport, Brussels Airport (Belgium) at 6/7/2026 7:30:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 6/7/2026 8:55:00 PM. 50 Economy ticket for $276 per person are available. Travel duration is 1h 25m
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FlixBus18h 35m010:55 PMBrusselsNorth Station5:30 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 6/7/2026 10:55:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/8/2026 5:30:00 PM. 50 Economy ticket for $82 per person are available. Travel duration is 18h 35m
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FlixBus17h 5m010:55 PMBrusselsNorth Station4:00 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 6/7/2026 10:55:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/8/2026 4:00:00 PM. 50 Economy ticket for $85 per person are available. Travel duration is 17h 5m
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FlixBus15h 0m010:30 PMBrusselsMidi Bus Station1:30 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 6/7/2026 10:30:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 6/8/2026 1:30:00 PM. 50 Economy ticket for $87 per person are available. Travel duration is 15h 0m
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FlixBus18h 40m09:50 PMBrussels AirportBrussels Airport4:30 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Brussels Airport, Brussels Airport (Belgium) at 6/7/2026 9:50:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 6/8/2026 4:30:00 PM. 50 Economy ticket for $87 per person are available. Travel duration is 18h 40m
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FlixBus22h 45m06:45 PMBrussels AirportBrussels Airport5:30 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Brussels Airport, Brussels Airport (Belgium) at 6/7/2026 6:45:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/8/2026 5:30:00 PM. 50 Economy ticket for $87 per person are available. Travel duration is 22h 45m
Cheapest Flights Sunday
Cheapest Buses Sunday
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Ryanair1h 30m01:35 PMBrussels South Charleroi AirportBrussels South Charleroi Airport3:05 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Ryanair goes from Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) at 6/8/2026 1:35:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/8/2026 3:05:00 PM. 50 Economy ticket for $34 per person are available. Travel duration is 1h 30m
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Brussels Airlines1h 25m09:00 PMBrussels AirportBrussels Airport10:25 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Brussels Airlines goes from Brussels Airport, Brussels Airport (Belgium) at 6/8/2026 9:00:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/8/2026 10:25:00 PM. 50 Economy ticket for $135 per person are available. Travel duration is 1h 25m
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Brussels Airlines1h 25m04:30 PMBrussels AirportBrussels Airport5:55 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Brussels Airlines goes from Brussels Airport, Brussels Airport (Belgium) at 6/8/2026 4:30:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/8/2026 5:55:00 PM. 50 Economy ticket for $138 per person are available. Travel duration is 1h 25m
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Jetairfly17h 20m07:10 AMAntwerp AirportAntwerp Airport12:30 AMPrague AirportPrague Airport0EconomyA Flight from Jetairfly goes from Antwerp Airport, Antwerp Airport (Belgium) at 6/8/2026 7:10:00 AM to Prague Airport, Prague Airport (Czech Republic) arriving at 6/9/2026 12:30:00 AM. 50 Economy ticket for $311 per person are available. Travel duration is 17h 20m
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Jetairfly10h 45m02:00 PMAntwerp AirportAntwerp Airport12:45 AMPrague AirportPrague Airport0EconomyA Flight from Jetairfly goes from Antwerp Airport, Antwerp Airport (Belgium) at 6/8/2026 2:00:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 6/9/2026 12:45:00 AM. 50 Economy ticket for $450 per person are available. Travel duration is 10h 45m
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FlixBus13h 35m010:30 AMBrusselsNorth Station12:05 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 6/8/2026 10:30:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 6/9/2026 12:05:00 AM. 50 Economy ticket for $47 per person are available. Travel duration is 13h 35m
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FlixBus13h 55m010:30 AMBrusselsNorth Station12:25 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 6/8/2026 10:30:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/9/2026 12:25:00 AM. 50 Economy ticket for $47 per person are available. Travel duration is 13h 55m
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FlixBus15h 0m010:30 PMBrusselsMidi Bus Station1:30 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 6/8/2026 10:30:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 6/9/2026 1:30:00 PM. 50 Economy ticket for $48 per person are available. Travel duration is 15h 0m
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European Sleeper15h 29m07:22 PMBrusselsMidi Bus Station10:51 AMPragueWilsonova Bus Station0EconomyA Bus from European Sleeper goes from Midi Bus Station, Brussels (Belgium) at 6/8/2026 7:22:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/9/2026 10:51:00 AM. 50 Economy ticket for $303 per person are available. Travel duration is 15h 29m
Cheapest Flights Monday
Cheapest Buses Monday
What are the fastest trips from Brussels to Prague?
You can get to Prague from Brussels in just 1h 25m with a Flight from Brussels Airlines. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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Brussels Airlines1h 25m04:30 PMBrussels AirportBrussels Airport5:55 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Brussels Airlines goes from Brussels Airport, Brussels Airport (Belgium) at 6/2/2026 4:30:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/2/2026 5:55:00 PM. 50 Economy ticket for $136 per person are available. Travel duration is 1h 25m
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Brussels Airlines1h 25m09:00 PMBrussels AirportBrussels Airport10:25 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Brussels Airlines goes from Brussels Airport, Brussels Airport (Belgium) at 6/2/2026 9:00:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/2/2026 10:25:00 PM. 50 Economy ticket for $136 per person are available. Travel duration is 1h 25m
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Ryanair1h 30m012:10 PMBrussels South Charleroi AirportBrussels South Charleroi Airport1:40 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Ryanair goes from Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) at 6/2/2026 12:10:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/2/2026 1:40:00 PM. 50 Economy ticket for $26 per person are available. Travel duration is 1h 30m
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Ryanair1h 30m07:55 AMBrussels South Charleroi AirportBrussels South Charleroi Airport9:25 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Ryanair goes from Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) at 6/2/2026 7:55:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/2/2026 9:25:00 AM. 50 Economy ticket for $29 per person are available. Travel duration is 1h 30m
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Jetairfly18h 25m02:30 PMAntwerp AirportAntwerp Airport8:55 AMPrague AirportPrague Airport0EconomyA Flight from Jetairfly goes from Antwerp Airport, Antwerp Airport (Belgium) at 6/2/2026 2:30:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 6/3/2026 8:55:00 AM. 50 Economy ticket for $304 per person are available. Travel duration is 18h 25m
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FlixBus21h 10m09:30 PMBrussels AirportBrussels Airport6:40 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Brussels Airport, Brussels Airport (Belgium) at 6/2/2026 9:30:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 6/3/2026 6:40:00 PM. 50 Economy ticket for $57 per person are available. Travel duration is 21h 10m
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FlixBus22h 40m02:05 PMBrussels AirportBrussels Airport12:45 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Brussels Airport, Brussels Airport (Belgium) at 6/2/2026 2:05:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 6/3/2026 12:45:00 PM. 50 Economy ticket for $58 per person are available. Travel duration is 22h 40m
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FlixBus22h 45m06:45 PMBrussels AirportBrussels Airport5:30 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Brussels Airport, Brussels Airport (Belgium) at 6/2/2026 6:45:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/3/2026 5:30:00 PM. 50 Economy ticket for $58 per person are available. Travel duration is 22h 45m
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FlixBus23h 25m09:45 AMBrussels AirportBrussels Airport9:10 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Brussels Airport, Brussels Airport (Belgium) at 6/2/2026 9:45:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 6/3/2026 9:10:00 AM. 50 Economy ticket for $57 per person are available. Travel duration is 23h 25m
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FlixBus24h 55m09:30 PMBrussels AirportBrussels Airport10:25 PMPragueČerný Most0EconomyA Bus from FlixBus goes from Brussels Airport, Brussels Airport (Belgium) at 6/2/2026 9:30:00 PM to Černý Most, Prague (Czech Republic) arriving at 6/3/2026 10:25:00 PM. 50 Economy ticket for $58 per person are available. Travel duration is 24h 55m
Fastest Flights Tuesday
Fastest Buses Tuesday
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Ryanair1h 30m07:30 PMBrussels AirportBrussels Airport9:00 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Ryanair goes from Brussels Airport, Brussels Airport (Belgium) at 6/3/2026 7:30:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/3/2026 9:00:00 PM. 50 Economy ticket for $31 per person are available. Travel duration is 1h 30m
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Buzz5h 30m012:55 PMBrussels South Charleroi AirportBrussels South Charleroi Airport6:25 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Buzz goes from Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) at 6/3/2026 12:55:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/3/2026 6:25:00 PM. 50 Economy ticket for $81 per person are available. Travel duration is 5h 30m
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LC Perú5h 40m09:40 AMBrussels South Charleroi AirportBrussels South Charleroi Airport3:20 PMPrague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) at 6/3/2026 9:40:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/3/2026 3:20:00 PM. 50 Economy ticket for $69 per person are available. Travel duration is 5h 40m
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Wizz Air11h 20m08:10 AMBrussels South Charleroi AirportBrussels South Charleroi Airport7:30 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Wizz Air goes from Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) at 6/3/2026 8:10:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/3/2026 7:30:00 PM. 50 Economy ticket for $59 per person are available. Travel duration is 11h 20m
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EasyJet Airline20h 0m09:15 PMBrussels AirportBrussels Airport5:15 PMPrague AirportPrague Airport0EconomyA Flight from EasyJet Airline goes from Brussels Airport, Brussels Airport (Belgium) at 6/3/2026 9:15:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 6/4/2026 5:15:00 PM. 50 Economy ticket for $104 per person are available. Travel duration is 20h 0m
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FlixBus12h 50m09:30 AMBrusselsNorth Station10:20 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 6/3/2026 9:30:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 6/3/2026 10:20:00 PM. 50 Economy ticket for $61 per person are available. Travel duration is 12h 50m
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European Sleeper15h 29m07:22 PMBrusselsMidi Bus Station10:51 AMPragueWilsonova Bus Station0EconomyA Bus from European Sleeper goes from Midi Bus Station, Brussels (Belgium) at 6/3/2026 7:22:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/4/2026 10:51:00 AM. 50 Economy ticket for $349 per person are available. Travel duration is 15h 29m
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FlixBus16h 30m09:30 PMBrusselsNorth Station2:00 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 6/3/2026 9:30:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/4/2026 2:00:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 16h 30m
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FlixBus17h 5m010:55 PMBrusselsNorth Station4:00 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 6/3/2026 10:55:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/4/2026 4:00:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 17h 5m
Fastest Flights Wednesday
Fastest Buses Wednesday
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Smartwings1h 25m08:55 AMBrussels AirportBrussels Airport10:20 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Smartwings goes from Brussels Airport, Brussels Airport (Belgium) at 6/4/2026 8:55:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/4/2026 10:20:00 AM. 50 Economy ticket for $108 per person are available. Travel duration is 1h 25m
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Smartwings1h 25m08:55 AMBrussels AirportBrussels Airport10:20 AMPrague AirportPrague Airport0EconomyA Flight from Smartwings goes from Brussels Airport, Brussels Airport (Belgium) at 6/4/2026 8:55:00 AM to Prague Airport, Prague Airport (Czech Republic) arriving at 6/4/2026 10:20:00 AM. 50 Economy ticket for $116 per person are available. Travel duration is 1h 25m
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Brussels Airlines1h 25m07:00 PMBrussels AirportBrussels Airport8:25 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Brussels Airlines goes from Brussels Airport, Brussels Airport (Belgium) at 6/4/2026 7:00:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/4/2026 8:25:00 PM. 50 Economy ticket for $137 per person are available. Travel duration is 1h 25m
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Brussels Airlines1h 25m09:00 PMBrussels AirportBrussels Airport10:25 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Brussels Airlines goes from Brussels Airport, Brussels Airport (Belgium) at 6/4/2026 9:00:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/4/2026 10:25:00 PM. 50 Economy ticket for $137 per person are available. Travel duration is 1h 25m
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Ryanair1h 30m012:40 PMBrussels South Charleroi AirportBrussels South Charleroi Airport2:10 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Ryanair goes from Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) at 6/4/2026 12:40:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/4/2026 2:10:00 PM. 50 Economy ticket for $29 per person are available. Travel duration is 1h 30m
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FlixBus12h 50m09:30 AMBrusselsNorth Station10:20 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 6/4/2026 9:30:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 6/4/2026 10:20:00 PM. 50 Economy ticket for $59 per person are available. Travel duration is 12h 50m
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FlixBus13h 35m010:30 AMBrusselsNorth Station12:05 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 6/4/2026 10:30:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 6/5/2026 12:05:00 AM. 50 Economy ticket for $59 per person are available. Travel duration is 13h 35m
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FlixBus13h 55m010:30 AMBrusselsNorth Station12:25 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 6/4/2026 10:30:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/5/2026 12:25:00 AM. 50 Economy ticket for $59 per person are available. Travel duration is 13h 55m
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FlixBus14h 40m04:15 PMBrusselsMidi Bus Station6:55 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 6/4/2026 4:15:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 6/5/2026 6:55:00 AM. 50 Economy ticket for $63 per person are available. Travel duration is 14h 40m
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FlixBus15h 0m010:30 PMBrusselsMidi Bus Station1:30 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 6/4/2026 10:30:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 6/5/2026 1:30:00 PM. 50 Economy ticket for $59 per person are available. Travel duration is 15h 0m
Fastest Flights Thursday
Fastest Buses Thursday
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Smartwings1h 25m08:55 AMBrussels AirportBrussels Airport10:20 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Smartwings goes from Brussels Airport, Brussels Airport (Belgium) at 6/5/2026 8:55:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/5/2026 10:20:00 AM. 50 Economy ticket for $110 per person are available. Travel duration is 1h 25m
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Brussels Airlines1h 25m04:30 PMBrussels AirportBrussels Airport5:55 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Brussels Airlines goes from Brussels Airport, Brussels Airport (Belgium) at 6/5/2026 4:30:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/5/2026 5:55:00 PM. 50 Economy ticket for $137 per person are available. Travel duration is 1h 25m
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Ryanair1h 30m07:30 PMBrussels South Charleroi AirportBrussels South Charleroi Airport9:00 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Ryanair goes from Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) at 6/5/2026 7:30:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/5/2026 9:00:00 PM. 50 Economy ticket for $44 per person are available. Travel duration is 1h 30m
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EasyJet Airline10h 45m09:10 PMBrussels AirportBrussels Airport7:55 AMPrague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Brussels Airport, Brussels Airport (Belgium) at 6/5/2026 9:10:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/6/2026 7:55:00 AM. 50 Economy ticket for $89 per person are available. Travel duration is 10h 45m
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Swiss International Air Lines13h 35m09:40 AMBrussels AirportBrussels Airport11:15 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Swiss International Air Lines goes from Brussels Airport, Brussels Airport (Belgium) at 6/5/2026 9:40:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/5/2026 11:15:00 PM. 50 Economy ticket for $172 per person are available. Travel duration is 13h 35m
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FlixBus13h 35m010:30 AMBrusselsNorth Station12:05 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 6/5/2026 10:30:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 6/6/2026 12:05:00 AM. 50 Economy ticket for $64 per person are available. Travel duration is 13h 35m
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FlixBus13h 55m010:30 AMBrusselsNorth Station12:25 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 6/5/2026 10:30:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/6/2026 12:25:00 AM. 50 Economy ticket for $64 per person are available. Travel duration is 13h 55m
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FlixBus15h 0m010:30 PMBrusselsMidi Bus Station1:30 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 6/5/2026 10:30:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 6/6/2026 1:30:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 15h 0m
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European Sleeper15h 29m07:22 PMBrusselsMidi Bus Station10:51 AMPragueWilsonova Bus Station0EconomyA Bus from European Sleeper goes from Midi Bus Station, Brussels (Belgium) at 6/5/2026 7:22:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/6/2026 10:51:00 AM. 50 Economy ticket for $233 per person are available. Travel duration is 15h 29m
Fastest Flights Friday
Fastest Buses Friday
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Buzz1h 30m012:35 PMBrussels South Charleroi AirportBrussels South Charleroi Airport2:05 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Buzz goes from Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) at 6/6/2026 12:35:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/6/2026 2:05:00 PM. 50 Economy ticket for $50 per person are available. Travel duration is 1h 30m
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Ryanair1h 30m012:35 PMBrussels AirportBrussels Airport2:05 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Ryanair goes from Brussels Airport, Brussels Airport (Belgium) at 6/6/2026 12:35:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/6/2026 2:05:00 PM. 50 Economy ticket for $51 per person are available. Travel duration is 1h 30m
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KLM Cityhopper4h 40m03:10 PMBrussels AirportBrussels Airport7:50 PMPrague AirportPrague Airport - T1/20EconomyA Flight from KLM Cityhopper goes from Brussels Airport, Brussels Airport (Belgium) at 6/6/2026 3:10:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/6/2026 7:50:00 PM. 50 Economy ticket for $146 per person are available. Travel duration is 4h 40m
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LC Perú6h 0m03:35 PMBrussels South Charleroi AirportBrussels South Charleroi Airport9:35 PMPrague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) at 6/6/2026 3:35:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/6/2026 9:35:00 PM. 50 Economy ticket for $56 per person are available. Travel duration is 6h 0m
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Skyscanner6h 35m07:55 AMBrussels South Charleroi AirportBrussels South Charleroi Airport2:30 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Skyscanner goes from Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) at 6/6/2026 7:55:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/6/2026 2:30:00 PM. 50 Economy ticket for $84 per person are available. Travel duration is 6h 35m
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FlixBus13h 35m010:30 AMBrusselsNorth Station12:05 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 6/6/2026 10:30:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 6/7/2026 12:05:00 AM. 50 Economy ticket for $63 per person are available. Travel duration is 13h 35m
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FlixBus13h 55m010:30 AMBrusselsNorth Station12:25 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 6/6/2026 10:30:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/7/2026 12:25:00 AM. 50 Economy ticket for $63 per person are available. Travel duration is 13h 55m
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FlixBus17h 50m01:20 AMBrusselsMidi Bus Station7:10 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 6/6/2026 1:20:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 6/6/2026 7:10:00 PM. 50 Economy ticket for $66 per person are available. Travel duration is 17h 50m
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FlixBus17h 50m01:20 AMBrusselsMidi Bus Station7:10 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 6/6/2026 1:20:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 6/6/2026 7:10:00 PM. 50 Economy ticket for $66 per person are available. Travel duration is 17h 50m
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FlixBus17h 55m03:15 AMBrusselsMidi Bus Station9:10 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 6/6/2026 3:15:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 6/6/2026 9:10:00 PM. 50 Economy ticket for $66 per person are available. Travel duration is 17h 55m
Fastest Flights Saturday
Fastest Buses Saturday
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Brussels Airlines1h 25m07:00 PMBrussels AirportBrussels Airport8:25 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Brussels Airlines goes from Brussels Airport, Brussels Airport (Belgium) at 6/7/2026 7:00:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/7/2026 8:25:00 PM. 50 Economy ticket for $135 per person are available. Travel duration is 1h 25m
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Brussels Airlines1h 25m09:00 PMBrussels AirportBrussels Airport10:25 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Brussels Airlines goes from Brussels Airport, Brussels Airport (Belgium) at 6/7/2026 9:00:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/7/2026 10:25:00 PM. 50 Economy ticket for $135 per person are available. Travel duration is 1h 25m
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Smartwings1h 25m07:30 PMBrussels AirportBrussels Airport8:55 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Smartwings goes from Brussels Airport, Brussels Airport (Belgium) at 6/7/2026 7:30:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/7/2026 8:55:00 PM. 50 Economy ticket for $264 per person are available. Travel duration is 1h 25m
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Smartwings1h 25m07:30 PMBrussels AirportBrussels Airport8:55 PMPrague AirportPrague Airport0EconomyA Flight from Smartwings goes from Brussels Airport, Brussels Airport (Belgium) at 6/7/2026 7:30:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 6/7/2026 8:55:00 PM. 50 Economy ticket for $276 per person are available. Travel duration is 1h 25m
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Ryanair1h 30m012:25 PMBrussels South Charleroi AirportBrussels South Charleroi Airport1:55 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Ryanair goes from Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) at 6/7/2026 12:25:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/7/2026 1:55:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 1h 30m
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FlixBus15h 0m010:30 PMBrusselsMidi Bus Station1:30 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 6/7/2026 10:30:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 6/8/2026 1:30:00 PM. 50 Economy ticket for $87 per person are available. Travel duration is 15h 0m
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FlixBus17h 5m010:55 PMBrusselsNorth Station4:00 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 6/7/2026 10:55:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/8/2026 4:00:00 PM. 50 Economy ticket for $85 per person are available. Travel duration is 17h 5m
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FlixBus18h 35m010:55 PMBrusselsNorth Station5:30 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 6/7/2026 10:55:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/8/2026 5:30:00 PM. 50 Economy ticket for $82 per person are available. Travel duration is 18h 35m
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FlixBus18h 40m09:50 PMBrussels AirportBrussels Airport4:30 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Brussels Airport, Brussels Airport (Belgium) at 6/7/2026 9:50:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 6/8/2026 4:30:00 PM. 50 Economy ticket for $87 per person are available. Travel duration is 18h 40m
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FlixBus22h 45m06:45 PMBrussels AirportBrussels Airport5:30 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Brussels Airport, Brussels Airport (Belgium) at 6/7/2026 6:45:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/8/2026 5:30:00 PM. 50 Economy ticket for $87 per person are available. Travel duration is 22h 45m
Fastest Flights Sunday
Fastest Buses Sunday
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Brussels Airlines1h 25m09:00 PMBrussels AirportBrussels Airport10:25 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Brussels Airlines goes from Brussels Airport, Brussels Airport (Belgium) at 6/8/2026 9:00:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/8/2026 10:25:00 PM. 50 Economy ticket for $135 per person are available. Travel duration is 1h 25m
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Brussels Airlines1h 25m04:30 PMBrussels AirportBrussels Airport5:55 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Brussels Airlines goes from Brussels Airport, Brussels Airport (Belgium) at 6/8/2026 4:30:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/8/2026 5:55:00 PM. 50 Economy ticket for $138 per person are available. Travel duration is 1h 25m
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Ryanair1h 30m01:35 PMBrussels South Charleroi AirportBrussels South Charleroi Airport3:05 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Ryanair goes from Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) at 6/8/2026 1:35:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 6/8/2026 3:05:00 PM. 50 Economy ticket for $34 per person are available. Travel duration is 1h 30m
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Jetairfly10h 45m02:00 PMAntwerp AirportAntwerp Airport12:45 AMPrague AirportPrague Airport0EconomyA Flight from Jetairfly goes from Antwerp Airport, Antwerp Airport (Belgium) at 6/8/2026 2:00:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 6/9/2026 12:45:00 AM. 50 Economy ticket for $450 per person are available. Travel duration is 10h 45m
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Jetairfly17h 20m07:10 AMAntwerp AirportAntwerp Airport12:30 AMPrague AirportPrague Airport0EconomyA Flight from Jetairfly goes from Antwerp Airport, Antwerp Airport (Belgium) at 6/8/2026 7:10:00 AM to Prague Airport, Prague Airport (Czech Republic) arriving at 6/9/2026 12:30:00 AM. 50 Economy ticket for $311 per person are available. Travel duration is 17h 20m
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FlixBus13h 35m010:30 AMBrusselsNorth Station12:05 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 6/8/2026 10:30:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 6/9/2026 12:05:00 AM. 50 Economy ticket for $47 per person are available. Travel duration is 13h 35m
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FlixBus13h 55m010:30 AMBrusselsNorth Station12:25 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 6/8/2026 10:30:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/9/2026 12:25:00 AM. 50 Economy ticket for $47 per person are available. Travel duration is 13h 55m
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FlixBus15h 0m010:30 PMBrusselsMidi Bus Station1:30 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 6/8/2026 10:30:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 6/9/2026 1:30:00 PM. 50 Economy ticket for $48 per person are available. Travel duration is 15h 0m
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European Sleeper15h 29m07:22 PMBrusselsMidi Bus Station10:51 AMPragueWilsonova Bus Station0EconomyA Bus from European Sleeper goes from Midi Bus Station, Brussels (Belgium) at 6/8/2026 7:22:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/9/2026 10:51:00 AM. 50 Economy ticket for $303 per person are available. Travel duration is 15h 29m
Fastest Flights Monday
Fastest Buses Monday
Here you will find all operators and timetables for a
Bus from Brussels to Prague
What are the most popular stations in Brussels and Prague?
In Brussels, you will usually depart from Midi Bus Station, North Station or Gare Centrale, while in Prague you will be arriving at Wilsonova Bus Station, ÚAN Florenc or Černý Most, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Prague from Brussels? With 9 connections between 2 Flight and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Brussels and Prague, you can pay as low as $26 with a Flight from Ryanair.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from Brussels Airlines: you will get to Prague in just 1h 25m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Brussels and Prague are FlixBus, Brussels Airlines and Ryanair, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Brussels and Prague is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Saint-Gilles or to Horoměřice, and look at flights from Brussels South Charleroi Airport, and landing at Prague Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Brussels to Prague?
The most popular companies between Brussels and Prague, are FlixBus, Brussels Airlines and Ryanair. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus and European Sleeper
Airlines: Brussels Airlines, Ryanair, Smartwings and 8 more.
All you need to know when you travel from Brussels to Prague
Check all information on comfort and services on all modes of transports from Brussels to Prague. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Brussels to Prague
How can I reach Prague from Brussels?
Every day, there are on average 9 connections between Flight and Bus, with which you can get to Prague from Brussels.
How far is Prague from Brussels?
The distance between Brussels and Prague is 446.6 miles.
What is the most ecofriendly mode of transport between Brussels and Prague?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 19 kgs of CO2, a train 25 kgs, a car 122 kgs, and a flight 177 kgs.
What is the cheapest mode of transport from Brussels to Prague?
You can get to Prague with just $26 by taking a Flight from Ryanair.
What is the fastest way to get from Brussels to Prague?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Prague in just 1h 25m with a Flight from Brussels Airlines.
More routes to Brussels and to Prague
Looking for more options? Here you can see the most popular routes to Brussels and to Prague. Simply click on a connection, and you’ll find all the details about the route!
