What is the best way to travel from Brussels to Prague?
Looking for a trip? Compare all the available Flights and Buses for the journey to Prague from Brussels. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
What is the cheapest way to reach Prague from Brussels?
You can get to Prague with just $29 by taking a Flight from Ryanair, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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FlixBus14h 5m010:25 AMBrusselsNorth Station12:30 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 11/5/2026 10:25:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 11/6/2026 12:30:00 AM. 50 Economy ticket for $66 per person are available. Travel duration is 14h 5m
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FlixBus14h 20m010:25 AMBrusselsNorth Station12:45 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 11/5/2026 10:25:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 11/6/2026 12:45:00 AM. 50 Economy ticket for $66 per person are available. Travel duration is 14h 20m
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FlixBus13h 10m08:20 AMBrusselsNorth Station9:30 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 11/5/2026 8:20:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/5/2026 9:30:00 PM. 50 Economy ticket for $79 per person are available. Travel duration is 13h 10m
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FlixBus18h 25m02:30 PMBrusselsNorth Station8:55 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 11/5/2026 2:30:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 11/6/2026 8:55:00 AM. 50 Economy ticket for $82 per person are available. Travel duration is 18h 25m
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FlixBus14h 40m04:15 PMBrusselsMidi Bus Station6:55 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 11/5/2026 4:15:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/6/2026 6:55:00 AM. 50 Economy ticket for $84 per person are available. Travel duration is 14h 40m
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Wizz Air11h 20m08:30 AMBrussels AirportBrussels Airport7:50 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Wizz Air goes from Brussels Airport, Brussels Airport (Belgium) at 11/5/2026 8:30:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 11/5/2026 7:50:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 11h 20m
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Wizz Air11h 20m08:30 AMBrussels South Charleroi AirportBrussels South Charleroi Airport7:50 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Wizz Air goes from Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) at 11/5/2026 8:30:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 11/5/2026 7:50:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 11h 20m
Cheapest Buses Thursday
Cheapest Flights Thursday
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Wizz Air11h 45m08:20 AMBrussels AirportBrussels Airport8:05 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Wizz Air goes from Brussels Airport, Brussels Airport (Belgium) at 11/6/2026 8:20:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 11/6/2026 8:05:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 11h 45m
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FlixBus14h 5m010:25 AMBrusselsNorth Station12:30 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 11/6/2026 10:25:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 11/7/2026 12:30:00 AM. 50 Economy ticket for $69 per person are available. Travel duration is 14h 5m
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FlixBus14h 20m010:25 AMBrusselsNorth Station12:45 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 11/6/2026 10:25:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 11/7/2026 12:45:00 AM. 50 Economy ticket for $69 per person are available. Travel duration is 14h 20m
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FlixBus13h 10m08:20 AMBrusselsNorth Station9:30 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 11/6/2026 8:20:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/6/2026 9:30:00 PM. 50 Economy ticket for $74 per person are available. Travel duration is 13h 10m
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European Sleeper16h 48m06:06 PMBrusselsMidi Bus Station10:54 AMPragueWilsonova Bus Station0EconomyA Bus from European Sleeper goes from Midi Bus Station, Brussels (Belgium) at 11/6/2026 6:06:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 11/7/2026 10:54:00 AM. 50 Economy ticket for $207 per person are available. Travel duration is 16h 48m
Cheapest Flights Friday
Cheapest Buses Friday
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Ryanair1h 30m02:25 PMBrussels AirportBrussels Airport3:55 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Ryanair goes from Brussels Airport, Brussels Airport (Belgium) at 11/7/2026 2:25:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 11/7/2026 3:55:00 PM. 50 Economy ticket for $57 per person are available. Travel duration is 1h 30m
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Ryanair1h 30m02:25 PMBrussels South Charleroi AirportBrussels South Charleroi Airport3:55 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Ryanair goes from Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) at 11/7/2026 2:25:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 11/7/2026 3:55:00 PM. 50 Economy ticket for $57 per person are available. Travel duration is 1h 30m
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FlixBus14h 40m04:15 PMBrusselsMidi Bus Station6:55 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 11/7/2026 4:15:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/8/2026 6:55:00 AM. 50 Economy ticket for $64 per person are available. Travel duration is 14h 40m
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FlixBus14h 5m010:25 AMBrusselsNorth Station12:30 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 11/7/2026 10:25:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 11/8/2026 12:30:00 AM. 50 Economy ticket for $69 per person are available. Travel duration is 14h 5m
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FlixBus14h 20m010:25 AMBrusselsNorth Station12:45 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 11/7/2026 10:25:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 11/8/2026 12:45:00 AM. 50 Economy ticket for $69 per person are available. Travel duration is 14h 20m
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FlixBus17h 50m01:20 AMBrusselsMidi Bus Station7:10 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 11/7/2026 1:20:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 11/7/2026 7:10:00 PM. 50 Economy ticket for $74 per person are available. Travel duration is 17h 50m
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FlixBus17h 50m01:20 AMBrusselsMidi Bus Station7:10 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 11/7/2026 1:20:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/7/2026 7:10:00 PM. 50 Economy ticket for $74 per person are available. Travel duration is 17h 50m
Cheapest Flights Saturday
Cheapest Buses Saturday
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FlixBus14h 40m04:15 PMBrusselsMidi Bus Station6:55 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 11/8/2026 4:15:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/9/2026 6:55:00 AM. 50 Economy ticket for $66 per person are available. Travel duration is 14h 40m
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FlixBus14h 5m010:25 AMBrusselsNorth Station12:30 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 11/8/2026 10:25:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 11/9/2026 12:30:00 AM. 50 Economy ticket for $72 per person are available. Travel duration is 14h 5m
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FlixBus14h 20m010:25 AMBrusselsNorth Station12:45 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 11/8/2026 10:25:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 11/9/2026 12:45:00 AM. 50 Economy ticket for $72 per person are available. Travel duration is 14h 20m
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FlixBus15h 40m09:30 PMBrusselsNorth Station1:10 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 11/8/2026 9:30:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/9/2026 1:10:00 PM. 50 Economy ticket for $82 per person are available. Travel duration is 15h 40m
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FlixBus16h 30m09:30 PMBrusselsNorth Station2:00 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 11/8/2026 9:30:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 11/9/2026 2:00:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 16h 30m
Cheapest Buses Sunday
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Ryanair1h 30m011:20 AMBrussels AirportBrussels Airport12:50 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Ryanair goes from Brussels Airport, Brussels Airport (Belgium) at 11/9/2026 11:20:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 11/9/2026 12:50:00 PM. 50 Economy ticket for $29 per person are available. Travel duration is 1h 30m
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Ryanair1h 30m011:20 AMBrussels South Charleroi AirportBrussels South Charleroi Airport12:50 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Ryanair goes from Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) at 11/9/2026 11:20:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 11/9/2026 12:50:00 PM. 50 Economy ticket for $29 per person are available. Travel duration is 1h 30m
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Ryanair1h 25m04:30 PMBrussels AirportBrussels Airport5:55 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Ryanair goes from Brussels Airport, Brussels Airport (Belgium) at 11/9/2026 4:30:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 11/9/2026 5:55:00 PM. 50 Economy ticket for $134 per person are available. Travel duration is 1h 25m
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FlixBus14h 40m04:15 PMBrusselsMidi Bus Station6:55 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 11/9/2026 4:15:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/10/2026 6:55:00 AM. 50 Economy ticket for $62 per person are available. Travel duration is 14h 40m
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FlixBus13h 10m07:50 AMBrusselsNorth Station9:00 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 11/9/2026 7:50:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/9/2026 9:00:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 13h 10m
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FlixBus16h 40m04:15 PMBrusselsMidi Bus Station8:55 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 11/9/2026 4:15:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 11/10/2026 8:55:00 AM. 50 Economy ticket for $64 per person are available. Travel duration is 16h 40m
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European Sleeper16h 54m06:06 PMBrusselsMidi Bus Station11:00 AMPragueWilsonova Bus Station0EconomyA Bus from European Sleeper goes from Midi Bus Station, Brussels (Belgium) at 11/9/2026 6:06:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 11/10/2026 11:00:00 AM. 50 Economy ticket for $529 per person are available. Travel duration is 16h 54m
Cheapest Flights Monday
Cheapest Buses Monday
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FlixBus14h 40m04:15 PMBrusselsMidi Bus Station6:55 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 11/10/2026 4:15:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/11/2026 6:55:00 AM. 50 Economy ticket for $62 per person are available. Travel duration is 14h 40m
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FlixBus14h 50m06:30 PMBrusselsNorth Station9:20 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 11/10/2026 6:30:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/11/2026 9:20:00 AM. 50 Economy ticket for $67 per person are available. Travel duration is 14h 50m
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FlixBus18h 40m01:20 AMBrusselsMidi Bus Station8:00 PMPragueHradčanská0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 11/10/2026 1:20:00 AM to Hradčanská, Prague (Czech Republic) arriving at 11/10/2026 8:00:00 PM. 50 Economy ticket for $68 per person are available. Travel duration is 18h 40m
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FlixBus17h 50m01:20 AMBrusselsMidi Bus Station7:10 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 11/10/2026 1:20:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 11/10/2026 7:10:00 PM. 50 Economy ticket for $68 per person are available. Travel duration is 17h 50m
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FlixBus17h 50m04:15 PMBrusselsMidi Bus Station10:05 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 11/10/2026 4:15:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 11/11/2026 10:05:00 AM. 50 Economy ticket for $68 per person are available. Travel duration is 17h 50m
Cheapest Buses Tuesday
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Ryanair1h 30m011:35 AMBrussels AirportBrussels Airport1:05 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Ryanair goes from Brussels Airport, Brussels Airport (Belgium) at 11/11/2026 11:35:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 11/11/2026 1:05:00 PM. 50 Economy ticket for $48 per person are available. Travel duration is 1h 30m
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Ryanair11h 30m09:05 PMBrussels AirportBrussels Airport8:35 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Ryanair goes from Brussels Airport, Brussels Airport (Belgium) at 11/11/2026 9:05:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 11/12/2026 8:35:00 AM. 50 Economy ticket for $101 per person are available. Travel duration is 11h 30m
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FlixBus17h 50m01:20 AMBrusselsMidi Bus Station7:10 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 11/11/2026 1:20:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 11/11/2026 7:10:00 PM. 50 Economy ticket for $71 per person are available. Travel duration is 17h 50m
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FlixBus18h 15m01:20 AMBrusselsMidi Bus Station7:35 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 11/11/2026 1:20:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/11/2026 7:35:00 PM. 50 Economy ticket for $71 per person are available. Travel duration is 18h 15m
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FlixBus14h 20m010:25 AMBrusselsNorth Station12:45 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 11/11/2026 10:25:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 11/12/2026 12:45:00 AM. 50 Economy ticket for $71 per person are available. Travel duration is 14h 20m
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European Sleeper16h 54m06:06 PMBrusselsMidi Bus Station11:00 AMPragueWilsonova Bus Station0EconomyA Bus from European Sleeper goes from Midi Bus Station, Brussels (Belgium) at 11/11/2026 6:06:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 11/12/2026 11:00:00 AM. 50 Economy ticket for $224 per person are available. Travel duration is 16h 54m
Cheapest Flights Wednesday
Cheapest Buses Wednesday
What are the fastest trips from Brussels to Prague?
You can get to Prague from Brussels in just 1h 25m with a Flight from Ryanair. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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Wizz Air11h 20m08:30 AMBrussels AirportBrussels Airport7:50 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Wizz Air goes from Brussels Airport, Brussels Airport (Belgium) at 11/5/2026 8:30:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 11/5/2026 7:50:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 11h 20m
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Wizz Air11h 20m08:30 AMBrussels South Charleroi AirportBrussels South Charleroi Airport7:50 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Wizz Air goes from Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) at 11/5/2026 8:30:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 11/5/2026 7:50:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 11h 20m
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FlixBus13h 10m08:20 AMBrusselsNorth Station9:30 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 11/5/2026 8:20:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/5/2026 9:30:00 PM. 50 Economy ticket for $79 per person are available. Travel duration is 13h 10m
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FlixBus14h 5m010:25 AMBrusselsNorth Station12:30 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 11/5/2026 10:25:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 11/6/2026 12:30:00 AM. 50 Economy ticket for $66 per person are available. Travel duration is 14h 5m
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FlixBus14h 20m010:25 AMBrusselsNorth Station12:45 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 11/5/2026 10:25:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 11/6/2026 12:45:00 AM. 50 Economy ticket for $66 per person are available. Travel duration is 14h 20m
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FlixBus14h 40m04:15 PMBrusselsMidi Bus Station6:55 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 11/5/2026 4:15:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/6/2026 6:55:00 AM. 50 Economy ticket for $84 per person are available. Travel duration is 14h 40m
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FlixBus18h 25m02:30 PMBrusselsNorth Station8:55 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 11/5/2026 2:30:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 11/6/2026 8:55:00 AM. 50 Economy ticket for $82 per person are available. Travel duration is 18h 25m
Fastest Flights Thursday
Fastest Buses Thursday
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Wizz Air11h 45m08:20 AMBrussels AirportBrussels Airport8:05 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Wizz Air goes from Brussels Airport, Brussels Airport (Belgium) at 11/6/2026 8:20:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 11/6/2026 8:05:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 11h 45m
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FlixBus13h 10m08:20 AMBrusselsNorth Station9:30 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 11/6/2026 8:20:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/6/2026 9:30:00 PM. 50 Economy ticket for $74 per person are available. Travel duration is 13h 10m
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FlixBus14h 5m010:25 AMBrusselsNorth Station12:30 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 11/6/2026 10:25:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 11/7/2026 12:30:00 AM. 50 Economy ticket for $69 per person are available. Travel duration is 14h 5m
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FlixBus14h 20m010:25 AMBrusselsNorth Station12:45 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 11/6/2026 10:25:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 11/7/2026 12:45:00 AM. 50 Economy ticket for $69 per person are available. Travel duration is 14h 20m
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European Sleeper16h 48m06:06 PMBrusselsMidi Bus Station10:54 AMPragueWilsonova Bus Station0EconomyA Bus from European Sleeper goes from Midi Bus Station, Brussels (Belgium) at 11/6/2026 6:06:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 11/7/2026 10:54:00 AM. 50 Economy ticket for $207 per person are available. Travel duration is 16h 48m
Fastest Flights Friday
Fastest Buses Friday
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Ryanair1h 30m02:25 PMBrussels AirportBrussels Airport3:55 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Ryanair goes from Brussels Airport, Brussels Airport (Belgium) at 11/7/2026 2:25:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 11/7/2026 3:55:00 PM. 50 Economy ticket for $57 per person are available. Travel duration is 1h 30m
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Ryanair1h 30m02:25 PMBrussels South Charleroi AirportBrussels South Charleroi Airport3:55 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Ryanair goes from Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) at 11/7/2026 2:25:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 11/7/2026 3:55:00 PM. 50 Economy ticket for $57 per person are available. Travel duration is 1h 30m
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FlixBus14h 5m010:25 AMBrusselsNorth Station12:30 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 11/7/2026 10:25:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 11/8/2026 12:30:00 AM. 50 Economy ticket for $69 per person are available. Travel duration is 14h 5m
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FlixBus14h 20m010:25 AMBrusselsNorth Station12:45 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 11/7/2026 10:25:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 11/8/2026 12:45:00 AM. 50 Economy ticket for $69 per person are available. Travel duration is 14h 20m
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FlixBus14h 40m04:15 PMBrusselsMidi Bus Station6:55 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 11/7/2026 4:15:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/8/2026 6:55:00 AM. 50 Economy ticket for $64 per person are available. Travel duration is 14h 40m
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FlixBus17h 50m01:20 AMBrusselsMidi Bus Station7:10 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 11/7/2026 1:20:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 11/7/2026 7:10:00 PM. 50 Economy ticket for $74 per person are available. Travel duration is 17h 50m
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FlixBus17h 50m01:20 AMBrusselsMidi Bus Station7:10 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 11/7/2026 1:20:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/7/2026 7:10:00 PM. 50 Economy ticket for $74 per person are available. Travel duration is 17h 50m
Fastest Flights Saturday
Fastest Buses Saturday
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FlixBus14h 5m010:25 AMBrusselsNorth Station12:30 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 11/8/2026 10:25:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 11/9/2026 12:30:00 AM. 50 Economy ticket for $72 per person are available. Travel duration is 14h 5m
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FlixBus14h 20m010:25 AMBrusselsNorth Station12:45 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 11/8/2026 10:25:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 11/9/2026 12:45:00 AM. 50 Economy ticket for $72 per person are available. Travel duration is 14h 20m
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FlixBus14h 40m04:15 PMBrusselsMidi Bus Station6:55 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 11/8/2026 4:15:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/9/2026 6:55:00 AM. 50 Economy ticket for $66 per person are available. Travel duration is 14h 40m
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FlixBus15h 40m09:30 PMBrusselsNorth Station1:10 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 11/8/2026 9:30:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/9/2026 1:10:00 PM. 50 Economy ticket for $82 per person are available. Travel duration is 15h 40m
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FlixBus16h 30m09:30 PMBrusselsNorth Station2:00 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 11/8/2026 9:30:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 11/9/2026 2:00:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 16h 30m
Fastest Buses Sunday
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Ryanair1h 25m04:30 PMBrussels AirportBrussels Airport5:55 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Ryanair goes from Brussels Airport, Brussels Airport (Belgium) at 11/9/2026 4:30:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 11/9/2026 5:55:00 PM. 50 Economy ticket for $134 per person are available. Travel duration is 1h 25m
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Ryanair1h 30m011:20 AMBrussels AirportBrussels Airport12:50 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Ryanair goes from Brussels Airport, Brussels Airport (Belgium) at 11/9/2026 11:20:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 11/9/2026 12:50:00 PM. 50 Economy ticket for $29 per person are available. Travel duration is 1h 30m
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Ryanair1h 30m011:20 AMBrussels South Charleroi AirportBrussels South Charleroi Airport12:50 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Ryanair goes from Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) at 11/9/2026 11:20:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 11/9/2026 12:50:00 PM. 50 Economy ticket for $29 per person are available. Travel duration is 1h 30m
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FlixBus13h 10m07:50 AMBrusselsNorth Station9:00 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 11/9/2026 7:50:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/9/2026 9:00:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 13h 10m
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FlixBus14h 40m04:15 PMBrusselsMidi Bus Station6:55 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 11/9/2026 4:15:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/10/2026 6:55:00 AM. 50 Economy ticket for $62 per person are available. Travel duration is 14h 40m
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FlixBus16h 40m04:15 PMBrusselsMidi Bus Station8:55 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 11/9/2026 4:15:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 11/10/2026 8:55:00 AM. 50 Economy ticket for $64 per person are available. Travel duration is 16h 40m
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European Sleeper16h 54m06:06 PMBrusselsMidi Bus Station11:00 AMPragueWilsonova Bus Station0EconomyA Bus from European Sleeper goes from Midi Bus Station, Brussels (Belgium) at 11/9/2026 6:06:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 11/10/2026 11:00:00 AM. 50 Economy ticket for $529 per person are available. Travel duration is 16h 54m
Fastest Flights Monday
Fastest Buses Monday
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FlixBus14h 40m04:15 PMBrusselsMidi Bus Station6:55 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 11/10/2026 4:15:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/11/2026 6:55:00 AM. 50 Economy ticket for $62 per person are available. Travel duration is 14h 40m
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FlixBus14h 50m06:30 PMBrusselsNorth Station9:20 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 11/10/2026 6:30:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/11/2026 9:20:00 AM. 50 Economy ticket for $67 per person are available. Travel duration is 14h 50m
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FlixBus17h 50m01:20 AMBrusselsMidi Bus Station7:10 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 11/10/2026 1:20:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 11/10/2026 7:10:00 PM. 50 Economy ticket for $68 per person are available. Travel duration is 17h 50m
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FlixBus17h 50m04:15 PMBrusselsMidi Bus Station10:05 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 11/10/2026 4:15:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 11/11/2026 10:05:00 AM. 50 Economy ticket for $68 per person are available. Travel duration is 17h 50m
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FlixBus18h 40m01:20 AMBrusselsMidi Bus Station8:00 PMPragueHradčanská0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 11/10/2026 1:20:00 AM to Hradčanská, Prague (Czech Republic) arriving at 11/10/2026 8:00:00 PM. 50 Economy ticket for $68 per person are available. Travel duration is 18h 40m
Fastest Buses Tuesday
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Ryanair1h 30m011:35 AMBrussels AirportBrussels Airport1:05 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Ryanair goes from Brussels Airport, Brussels Airport (Belgium) at 11/11/2026 11:35:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 11/11/2026 1:05:00 PM. 50 Economy ticket for $48 per person are available. Travel duration is 1h 30m
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Ryanair11h 30m09:05 PMBrussels AirportBrussels Airport8:35 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Ryanair goes from Brussels Airport, Brussels Airport (Belgium) at 11/11/2026 9:05:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 11/12/2026 8:35:00 AM. 50 Economy ticket for $101 per person are available. Travel duration is 11h 30m
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FlixBus14h 20m010:25 AMBrusselsNorth Station12:45 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from North Station, Brussels (Belgium) at 11/11/2026 10:25:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 11/12/2026 12:45:00 AM. 50 Economy ticket for $71 per person are available. Travel duration is 14h 20m
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European Sleeper16h 54m06:06 PMBrusselsMidi Bus Station11:00 AMPragueWilsonova Bus Station0EconomyA Bus from European Sleeper goes from Midi Bus Station, Brussels (Belgium) at 11/11/2026 6:06:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 11/12/2026 11:00:00 AM. 50 Economy ticket for $224 per person are available. Travel duration is 16h 54m
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FlixBus17h 50m01:20 AMBrusselsMidi Bus Station7:10 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 11/11/2026 1:20:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 11/11/2026 7:10:00 PM. 50 Economy ticket for $71 per person are available. Travel duration is 17h 50m
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FlixBus18h 15m01:20 AMBrusselsMidi Bus Station7:35 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 11/11/2026 1:20:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/11/2026 7:35:00 PM. 50 Economy ticket for $71 per person are available. Travel duration is 18h 15m
Fastest Flights Wednesday
Fastest Buses Wednesday
Here you will find all operators and timetables for a
Bus from Brussels to Prague
What are the most popular stations in Brussels and Prague?
In Brussels, you will usually depart from North Station, Midi Bus Station or Gare Centrale, while in Prague you will be arriving at Wilsonova Bus Station, ÚAN Florenc or Roztyly, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Prague from Brussels? With 6 connections between 2 Flight and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Brussels and Prague, you can pay as low as $29 with a Flight from Ryanair.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from Ryanair: you will get to Prague in just 1h 25m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Brussels and Prague are FlixBus, Ryanair and European Sleeper, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Brussels and Prague is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Saint-Gilles or to Horoměřice, and look at flights from Brussels South Charleroi Airport, and landing at Prague Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Brussels to Prague?
The most popular companies between Brussels and Prague, are FlixBus, Ryanair and European Sleeper. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus and European Sleeper
Airlines: Ryanair and Wizz Air
All you need to know when you travel from Brussels to Prague
Check all information on comfort and services on all modes of transports from Brussels to Prague. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Brussels to Prague
How can I reach Prague from Brussels?
Every day, there are on average 6 connections between Flight and Bus, with which you can get to Prague from Brussels.
How far is Prague from Brussels?
The distance between Brussels and Prague is 446.6 miles.
What is the most ecofriendly mode of transport between Brussels and Prague?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 19 kgs of CO2, a train 25 kgs, a car 122 kgs, and a flight 177 kgs.
What is the cheapest mode of transport from Brussels to Prague?
You can get to Prague with just $29 by taking a Flight from Ryanair.
What is the fastest way to get from Brussels to Prague?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Prague in just 1h 25m with a Flight from Ryanair.
More routes to Brussels and to Prague
Looking for more options? Here you can see the most popular routes to Brussels and to Prague. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Brussels
- Amsterdam Schiphol Airport to Brussels
- Amsterdam to Brussels
- Basel to Brussels
- Berlin to Brussels
- Birmingham to Brussels
- Bristol to Brussels
- Bruges (BE) to Brussels
- Brussels South Charleroi Airport to Brussels
- Dusseldorf to Brussels
- Frankfurt am Main to Brussels
- Graz to Brussels
- Innsbruck to Brussels
- Lille to Brussels
- Lisbon to Brussels
- London to Brussels
- Lyon to Brussels
- Metz to Brussels
- Milan to Brussels
- Munich to Brussels
- Paris to Brussels
- Porto to Brussels
- Prague to Brussels
- Warsaw to Brussels
- Zurich to Brussels
- Trips to Prague
- Berlin to Prague
- Ceske Budejovice to Prague
- Český Krumlov to Prague
- Dresden to Prague
- Dusseldorf to Prague
- Hamburg to Prague
- Humpolec to Prague
- Jihlava to Prague
- Karvina to Prague
- Katowice to Prague
- Leipzig to Prague
- Manchester to Prague
- Middlesbrough to Prague
- Minsk to Prague
- Munich to Prague
- Ostrava to Prague
- Paris to Prague
- Poznan to Prague
- Stockholm to Prague
- Třebíč to Prague
- Vienna Airport to Prague
- Vienna to Prague
- Warsaw to Prague
- Wroclaw to Prague
