What is the best way to travel from Prague to Brussels?
Looking for a trip? Compare all the available Buses and Flights for the journey to Brussels from Prague. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 4 available companies to find your perfect trip!
What is the cheapest way to reach Brussels from Prague?
You can get to Brussels with just $50 by taking a Bus from FlixBus, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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FlixBus17h 0m01:45 AMPragueWilsonova Bus Station6:45 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 12/5/2025 1:45:00 AM to North Station, Brussels (Belgium) arriving at 12/5/2025 6:45:00 PM. 50 Economy ticket for $68 per person are available. Travel duration is 17h 0m
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FlixBus15h 35m05:45 PMPragueNa Knížecí Station9:20 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 12/5/2025 5:45:00 PM to North Station, Brussels (Belgium) arriving at 12/6/2025 9:20:00 AM. 50 Economy ticket for $68 per person are available. Travel duration is 15h 35m
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FlixBus19h 50m05:50 AMPragueWilsonova Bus Station1:40 AMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 12/5/2025 5:50:00 AM to Midi Bus Station, Brussels (Belgium) arriving at 12/6/2025 1:40:00 AM. 50 Economy ticket for $68 per person are available. Travel duration is 19h 50m
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FlixBus19h 20m08:15 PMPragueÚAN Florenc3:35 PMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 12/5/2025 8:15:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 12/6/2025 3:35:00 PM. 50 Economy ticket for $68 per person are available. Travel duration is 19h 20m
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FlixBus18h 55m08:40 PMPragueNa Knížecí Station3:35 PMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 12/5/2025 8:40:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 12/6/2025 3:35:00 PM. 50 Economy ticket for $68 per person are available. Travel duration is 18h 55m
Cheapest Buses Friday
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FlixBus17h 45m02:45 PMPragueWilsonova Bus Station8:30 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 12/6/2025 2:45:00 PM to North Station, Brussels (Belgium) arriving at 12/7/2025 8:30:00 AM. 50 Economy ticket for $53 per person are available. Travel duration is 17h 45m
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FlixBus17h 5m03:45 PMPragueWilsonova Bus Station8:50 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 12/6/2025 3:45:00 PM to North Station, Brussels (Belgium) arriving at 12/7/2025 8:50:00 AM. 50 Economy ticket for $53 per person are available. Travel duration is 17h 5m
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FlixBus15h 55m05:30 PMPragueWilsonova Bus Station9:25 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 12/6/2025 5:30:00 PM to North Station, Brussels (Belgium) arriving at 12/7/2025 9:25:00 AM. 50 Economy ticket for $53 per person are available. Travel duration is 15h 55m
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FlixBus15h 35m05:45 PMPragueNa Knížecí Station9:20 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 12/6/2025 5:45:00 PM to North Station, Brussels (Belgium) arriving at 12/7/2025 9:20:00 AM. 50 Economy ticket for $53 per person are available. Travel duration is 15h 35m
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FlixBus17h 55m012:50 PMPragueHradčanská6:45 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Hradčanská, Prague (Czech Republic) at 12/6/2025 12:50:00 PM to North Station, Brussels (Belgium) arriving at 12/7/2025 6:45:00 AM. 50 Economy ticket for $53 per person are available. Travel duration is 17h 55m
Cheapest Buses Saturday
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FlixBus18h 25m012:55 PMPragueZličín7:20 AMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from Zličín, Prague (Czech Republic) at 12/7/2025 12:55:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 12/8/2025 7:20:00 AM. 50 Economy ticket for $66 per person are available. Travel duration is 18h 25m
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FlixBus19h 0m05:45 PMPragueNa Knížecí Station12:45 PMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 12/7/2025 5:45:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 12/8/2025 12:45:00 PM. 50 Economy ticket for $66 per person are available. Travel duration is 19h 0m
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FlixBus17h 0m01:45 AMPragueWilsonova Bus Station6:45 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 12/7/2025 1:45:00 AM to North Station, Brussels (Belgium) arriving at 12/7/2025 6:45:00 PM. 50 Economy ticket for $67 per person are available. Travel duration is 17h 0m
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European Sleeper15h 25m06:02 PMPragueWilsonova Bus Station9:27 AMBrusselsMidi Bus Station0EconomyA Bus from European Sleeper goes from Wilsonova Bus Station, Prague (Czech Republic) at 12/7/2025 6:02:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 12/8/2025 9:27:00 AM. 50 Economy ticket for $286 per person are available. Travel duration is 15h 25m
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Ryanair18h 15m07:30 PMPrague AirportPrague Airport - T1/21:45 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Ryanair goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 12/7/2025 7:30:00 PM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/8/2025 1:45:00 PM. 50 Economy ticket for $154 per person are available. Travel duration is 18h 15m
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Bringer Air Cargo Taxi Aereo15h 35m05:05 AMPrague AirportPrague Airport - T1/28:40 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Bringer Air Cargo Taxi Aereo goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 12/7/2025 5:05:00 AM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/7/2025 8:40:00 PM. 50 Economy ticket for $164 per person are available. Travel duration is 15h 35m
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Smartwings31h 45m06:00 AMPrague AirportPrague Airport - T1/21:45 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Smartwings goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 12/7/2025 6:00:00 AM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/8/2025 1:45:00 PM. 50 Economy ticket for $165 per person are available. Travel duration is 31h 45m
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Smartwings14h 40m06:00 AMPrague AirportPrague Airport - T1/28:40 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Smartwings goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 12/7/2025 6:00:00 AM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/7/2025 8:40:00 PM. 50 Economy ticket for $165 per person are available. Travel duration is 14h 40m
Cheapest Buses Sunday
Cheapest Flights Sunday
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FlixBus19h 30m010:45 PMPrague AirportPrague Airport - T1/26:15 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 12/8/2025 10:45:00 PM to North Station, Brussels (Belgium) arriving at 12/9/2025 6:15:00 PM. 50 Economy ticket for $53 per person are available. Travel duration is 19h 30m
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FlixBus20h 0m010:15 PMPragueNa Knížecí Station6:15 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 12/8/2025 10:15:00 PM to North Station, Brussels (Belgium) arriving at 12/9/2025 6:15:00 PM. 50 Economy ticket for $54 per person are available. Travel duration is 20h 0m
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FlixBus16h 5m05:15 PMPragueÚAN Florenc9:20 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 12/8/2025 5:15:00 PM to North Station, Brussels (Belgium) arriving at 12/9/2025 9:20:00 AM. 50 Economy ticket for $54 per person are available. Travel duration is 16h 5m
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FlixBus18h 40m08:00 PMPragueÚAN Florenc2:40 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 12/8/2025 8:00:00 PM to North Station, Brussels (Belgium) arriving at 12/9/2025 2:40:00 PM. 50 Economy ticket for $54 per person are available. Travel duration is 18h 40m
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FlixBus17h 45m04:15 PMPragueÚAN Florenc10:00 AMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 12/8/2025 4:15:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 12/9/2025 10:00:00 AM. 50 Economy ticket for $54 per person are available. Travel duration is 17h 45m
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Jet2.com24h 30m07:35 PMPrague AirportPrague Airport - T1/28:05 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Jet2.com goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 12/8/2025 7:35:00 PM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/9/2025 8:05:00 PM. 50 Economy ticket for $235 per person are available. Travel duration is 24h 30m
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Ryanair25h 25m06:40 PMPrague AirportPrague Airport - T1/28:05 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Ryanair goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 12/8/2025 6:40:00 PM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/9/2025 8:05:00 PM. 50 Economy ticket for $235 per person are available. Travel duration is 25h 25m
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Transavia Airlines10h 40m08:55 AMPrague AirportPrague Airport - T1/27:35 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Transavia Airlines goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 12/8/2025 8:55:00 AM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/8/2025 7:35:00 PM. 50 Economy ticket for $256 per person are available. Travel duration is 10h 40m
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EasyJet Airline29h 10m02:55 PMPrague AirportPrague Airport - T1/28:05 PMAntwerp AirportAntwerp Airport0EconomyA Flight from EasyJet Airline goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 12/8/2025 2:55:00 PM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/9/2025 8:05:00 PM. 50 Economy ticket for $257 per person are available. Travel duration is 29h 10m
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Buzz29h 0m03:05 PMPrague AirportPrague Airport - T1/28:05 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Buzz goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 12/8/2025 3:05:00 PM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/9/2025 8:05:00 PM. 50 Economy ticket for $290 per person are available. Travel duration is 29h 0m
Cheapest Buses Monday
Cheapest Flights Monday
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FlixBus21h 25m05:15 PMPragueWilsonova Bus Station2:40 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 12/9/2025 5:15:00 PM to North Station, Brussels (Belgium) arriving at 12/10/2025 2:40:00 PM. 50 Economy ticket for $52 per person are available. Travel duration is 21h 25m
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FlixBus18h 40m08:00 PMPragueÚAN Florenc2:40 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 12/9/2025 8:00:00 PM to North Station, Brussels (Belgium) arriving at 12/10/2025 2:40:00 PM. 50 Economy ticket for $52 per person are available. Travel duration is 18h 40m
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FlixBus21h 5m09:40 AMPragueNa Knížecí Station6:45 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 12/9/2025 9:40:00 AM to North Station, Brussels (Belgium) arriving at 12/10/2025 6:45:00 AM. 50 Economy ticket for $52 per person are available. Travel duration is 21h 5m
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European Sleeper16h 37m06:02 PMPragueWilsonova Bus Station10:39 AMBrusselsMidi Bus Station0EconomyA Bus from European Sleeper goes from Wilsonova Bus Station, Prague (Czech Republic) at 12/9/2025 6:02:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 12/10/2025 10:39:00 AM. 50 Economy ticket for $310 per person are available. Travel duration is 16h 37m
Cheapest Buses Tuesday
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FlixBus21h 25m05:15 PMPragueWilsonova Bus Station2:40 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 12/10/2025 5:15:00 PM to North Station, Brussels (Belgium) arriving at 12/11/2025 2:40:00 PM. 50 Economy ticket for $50 per person are available. Travel duration is 21h 25m
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FlixBus15h 55m05:30 PMPragueWilsonova Bus Station9:25 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 12/10/2025 5:30:00 PM to North Station, Brussels (Belgium) arriving at 12/11/2025 9:25:00 AM. 50 Economy ticket for $50 per person are available. Travel duration is 15h 55m
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FlixBus15h 25m06:00 PMPragueÚAN Florenc9:25 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 12/10/2025 6:00:00 PM to North Station, Brussels (Belgium) arriving at 12/11/2025 9:25:00 AM. 50 Economy ticket for $50 per person are available. Travel duration is 15h 25m
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FlixBus20h 10m09:55 PMPragueÚAN Florenc6:05 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 12/10/2025 9:55:00 PM to North Station, Brussels (Belgium) arriving at 12/11/2025 6:05:00 PM. 50 Economy ticket for $50 per person are available. Travel duration is 20h 10m
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FlixBus21h 5m09:40 AMPragueNa Knížecí Station6:45 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 12/10/2025 9:40:00 AM to North Station, Brussels (Belgium) arriving at 12/11/2025 6:45:00 AM. 50 Economy ticket for $50 per person are available. Travel duration is 21h 5m
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Buzz31h 45m06:00 AMPrague AirportPrague Airport - T1/21:45 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Buzz goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 12/10/2025 6:00:00 AM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/11/2025 1:45:00 PM. 50 Economy ticket for $168 per person are available. Travel duration is 31h 45m
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Wizz Air29h 40m08:05 AMPrague AirportPrague Airport - T1/21:45 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Wizz Air goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 12/10/2025 8:05:00 AM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/11/2025 1:45:00 PM. 50 Economy ticket for $205 per person are available. Travel duration is 29h 40m
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Smartwings25h 45m012:00 PMPrague AirportPrague Airport - T1/21:45 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Smartwings goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 12/10/2025 12:00:00 PM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/11/2025 1:45:00 PM. 50 Economy ticket for $229 per person are available. Travel duration is 25h 45m
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EasyJet Airline26h 20m011:25 AMPrague AirportPrague Airport - T1/21:45 PMAntwerp AirportAntwerp Airport0EconomyA Flight from EasyJet Airline goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 12/10/2025 11:25:00 AM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/11/2025 1:45:00 PM. 50 Economy ticket for $252 per person are available. Travel duration is 26h 20m
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Austrian Airlines30h 20m07:25 AMPrague AirportPrague Airport - T1/21:45 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Austrian Airlines goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 12/10/2025 7:25:00 AM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/11/2025 1:45:00 PM. 50 Economy ticket for $258 per person are available. Travel duration is 30h 20m
Cheapest Buses Wednesday
Cheapest Flights Wednesday
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FlixBus18h 30m012:50 PMPragueHradčanská7:20 AMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from Hradčanská, Prague (Czech Republic) at 12/11/2025 12:50:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 12/12/2025 7:20:00 AM. 50 Economy ticket for $51 per person are available. Travel duration is 18h 30m
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FlixBus18h 15m010:15 PMPragueNa Knížecí Station4:30 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 12/11/2025 10:15:00 PM to North Station, Brussels (Belgium) arriving at 12/12/2025 4:30:00 PM. 50 Economy ticket for $52 per person are available. Travel duration is 18h 15m
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FlixBus15h 25m06:00 PMPragueÚAN Florenc9:25 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 12/11/2025 6:00:00 PM to North Station, Brussels (Belgium) arriving at 12/12/2025 9:25:00 AM. 50 Economy ticket for $52 per person are available. Travel duration is 15h 25m
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European Sleeper15h 25m06:02 PMPragueWilsonova Bus Station9:27 AMBrusselsMidi Bus Station0EconomyA Bus from European Sleeper goes from Wilsonova Bus Station, Prague (Czech Republic) at 12/11/2025 6:02:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 12/12/2025 9:27:00 AM. 50 Economy ticket for $245 per person are available. Travel duration is 15h 25m
Cheapest Buses Thursday
What are the fastest trips from Prague to Brussels?
You can get to Brussels from Prague in just 10h 40m with a Flight from Transavia Airlines. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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FlixBus15h 35m05:45 PMPragueNa Knížecí Station9:20 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 12/5/2025 5:45:00 PM to North Station, Brussels (Belgium) arriving at 12/6/2025 9:20:00 AM. 50 Economy ticket for $68 per person are available. Travel duration is 15h 35m
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FlixBus17h 0m01:45 AMPragueWilsonova Bus Station6:45 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 12/5/2025 1:45:00 AM to North Station, Brussels (Belgium) arriving at 12/5/2025 6:45:00 PM. 50 Economy ticket for $68 per person are available. Travel duration is 17h 0m
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FlixBus18h 55m08:40 PMPragueNa Knížecí Station3:35 PMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 12/5/2025 8:40:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 12/6/2025 3:35:00 PM. 50 Economy ticket for $68 per person are available. Travel duration is 18h 55m
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FlixBus19h 20m08:15 PMPragueÚAN Florenc3:35 PMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 12/5/2025 8:15:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 12/6/2025 3:35:00 PM. 50 Economy ticket for $68 per person are available. Travel duration is 19h 20m
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FlixBus19h 50m05:50 AMPragueWilsonova Bus Station1:40 AMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 12/5/2025 5:50:00 AM to Midi Bus Station, Brussels (Belgium) arriving at 12/6/2025 1:40:00 AM. 50 Economy ticket for $68 per person are available. Travel duration is 19h 50m
Fastest Buses Friday
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FlixBus15h 35m05:45 PMPragueNa Knížecí Station9:20 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 12/6/2025 5:45:00 PM to North Station, Brussels (Belgium) arriving at 12/7/2025 9:20:00 AM. 50 Economy ticket for $53 per person are available. Travel duration is 15h 35m
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FlixBus15h 55m05:30 PMPragueWilsonova Bus Station9:25 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 12/6/2025 5:30:00 PM to North Station, Brussels (Belgium) arriving at 12/7/2025 9:25:00 AM. 50 Economy ticket for $53 per person are available. Travel duration is 15h 55m
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FlixBus17h 5m03:45 PMPragueWilsonova Bus Station8:50 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 12/6/2025 3:45:00 PM to North Station, Brussels (Belgium) arriving at 12/7/2025 8:50:00 AM. 50 Economy ticket for $53 per person are available. Travel duration is 17h 5m
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FlixBus17h 45m02:45 PMPragueWilsonova Bus Station8:30 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 12/6/2025 2:45:00 PM to North Station, Brussels (Belgium) arriving at 12/7/2025 8:30:00 AM. 50 Economy ticket for $53 per person are available. Travel duration is 17h 45m
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FlixBus17h 55m012:50 PMPragueHradčanská6:45 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Hradčanská, Prague (Czech Republic) at 12/6/2025 12:50:00 PM to North Station, Brussels (Belgium) arriving at 12/7/2025 6:45:00 AM. 50 Economy ticket for $53 per person are available. Travel duration is 17h 55m
Fastest Buses Saturday
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Smartwings14h 40m06:00 AMPrague AirportPrague Airport - T1/28:40 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Smartwings goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 12/7/2025 6:00:00 AM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/7/2025 8:40:00 PM. 50 Economy ticket for $165 per person are available. Travel duration is 14h 40m
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Bringer Air Cargo Taxi Aereo15h 35m05:05 AMPrague AirportPrague Airport - T1/28:40 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Bringer Air Cargo Taxi Aereo goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 12/7/2025 5:05:00 AM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/7/2025 8:40:00 PM. 50 Economy ticket for $164 per person are available. Travel duration is 15h 35m
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Ryanair18h 15m07:30 PMPrague AirportPrague Airport - T1/21:45 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Ryanair goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 12/7/2025 7:30:00 PM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/8/2025 1:45:00 PM. 50 Economy ticket for $154 per person are available. Travel duration is 18h 15m
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Smartwings31h 45m06:00 AMPrague AirportPrague Airport - T1/21:45 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Smartwings goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 12/7/2025 6:00:00 AM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/8/2025 1:45:00 PM. 50 Economy ticket for $165 per person are available. Travel duration is 31h 45m
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European Sleeper15h 25m06:02 PMPragueWilsonova Bus Station9:27 AMBrusselsMidi Bus Station0EconomyA Bus from European Sleeper goes from Wilsonova Bus Station, Prague (Czech Republic) at 12/7/2025 6:02:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 12/8/2025 9:27:00 AM. 50 Economy ticket for $286 per person are available. Travel duration is 15h 25m
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FlixBus17h 0m01:45 AMPragueWilsonova Bus Station6:45 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 12/7/2025 1:45:00 AM to North Station, Brussels (Belgium) arriving at 12/7/2025 6:45:00 PM. 50 Economy ticket for $67 per person are available. Travel duration is 17h 0m
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FlixBus18h 25m012:55 PMPragueZličín7:20 AMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from Zličín, Prague (Czech Republic) at 12/7/2025 12:55:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 12/8/2025 7:20:00 AM. 50 Economy ticket for $66 per person are available. Travel duration is 18h 25m
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FlixBus19h 0m05:45 PMPragueNa Knížecí Station12:45 PMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 12/7/2025 5:45:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 12/8/2025 12:45:00 PM. 50 Economy ticket for $66 per person are available. Travel duration is 19h 0m
Fastest Flights Sunday
Fastest Buses Sunday
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Transavia Airlines10h 40m08:55 AMPrague AirportPrague Airport - T1/27:35 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Transavia Airlines goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 12/8/2025 8:55:00 AM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/8/2025 7:35:00 PM. 50 Economy ticket for $256 per person are available. Travel duration is 10h 40m
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Jet2.com24h 30m07:35 PMPrague AirportPrague Airport - T1/28:05 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Jet2.com goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 12/8/2025 7:35:00 PM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/9/2025 8:05:00 PM. 50 Economy ticket for $235 per person are available. Travel duration is 24h 30m
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Ryanair25h 25m06:40 PMPrague AirportPrague Airport - T1/28:05 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Ryanair goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 12/8/2025 6:40:00 PM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/9/2025 8:05:00 PM. 50 Economy ticket for $235 per person are available. Travel duration is 25h 25m
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Buzz29h 0m03:05 PMPrague AirportPrague Airport - T1/28:05 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Buzz goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 12/8/2025 3:05:00 PM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/9/2025 8:05:00 PM. 50 Economy ticket for $290 per person are available. Travel duration is 29h 0m
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EasyJet Airline29h 10m02:55 PMPrague AirportPrague Airport - T1/28:05 PMAntwerp AirportAntwerp Airport0EconomyA Flight from EasyJet Airline goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 12/8/2025 2:55:00 PM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/9/2025 8:05:00 PM. 50 Economy ticket for $257 per person are available. Travel duration is 29h 10m
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FlixBus16h 5m05:15 PMPragueÚAN Florenc9:20 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 12/8/2025 5:15:00 PM to North Station, Brussels (Belgium) arriving at 12/9/2025 9:20:00 AM. 50 Economy ticket for $54 per person are available. Travel duration is 16h 5m
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FlixBus17h 45m04:15 PMPragueÚAN Florenc10:00 AMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 12/8/2025 4:15:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 12/9/2025 10:00:00 AM. 50 Economy ticket for $54 per person are available. Travel duration is 17h 45m
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FlixBus18h 40m08:00 PMPragueÚAN Florenc2:40 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 12/8/2025 8:00:00 PM to North Station, Brussels (Belgium) arriving at 12/9/2025 2:40:00 PM. 50 Economy ticket for $54 per person are available. Travel duration is 18h 40m
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FlixBus19h 30m010:45 PMPrague AirportPrague Airport - T1/26:15 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 12/8/2025 10:45:00 PM to North Station, Brussels (Belgium) arriving at 12/9/2025 6:15:00 PM. 50 Economy ticket for $53 per person are available. Travel duration is 19h 30m
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FlixBus20h 0m010:15 PMPragueNa Knížecí Station6:15 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 12/8/2025 10:15:00 PM to North Station, Brussels (Belgium) arriving at 12/9/2025 6:15:00 PM. 50 Economy ticket for $54 per person are available. Travel duration is 20h 0m
Fastest Flights Monday
Fastest Buses Monday
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European Sleeper16h 37m06:02 PMPragueWilsonova Bus Station10:39 AMBrusselsMidi Bus Station0EconomyA Bus from European Sleeper goes from Wilsonova Bus Station, Prague (Czech Republic) at 12/9/2025 6:02:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 12/10/2025 10:39:00 AM. 50 Economy ticket for $310 per person are available. Travel duration is 16h 37m
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FlixBus18h 40m08:00 PMPragueÚAN Florenc2:40 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 12/9/2025 8:00:00 PM to North Station, Brussels (Belgium) arriving at 12/10/2025 2:40:00 PM. 50 Economy ticket for $52 per person are available. Travel duration is 18h 40m
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FlixBus21h 5m09:40 AMPragueNa Knížecí Station6:45 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 12/9/2025 9:40:00 AM to North Station, Brussels (Belgium) arriving at 12/10/2025 6:45:00 AM. 50 Economy ticket for $52 per person are available. Travel duration is 21h 5m
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FlixBus21h 25m05:15 PMPragueWilsonova Bus Station2:40 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 12/9/2025 5:15:00 PM to North Station, Brussels (Belgium) arriving at 12/10/2025 2:40:00 PM. 50 Economy ticket for $52 per person are available. Travel duration is 21h 25m
Fastest Buses Tuesday
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FlixBus15h 25m06:00 PMPragueÚAN Florenc9:25 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 12/10/2025 6:00:00 PM to North Station, Brussels (Belgium) arriving at 12/11/2025 9:25:00 AM. 50 Economy ticket for $50 per person are available. Travel duration is 15h 25m
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FlixBus15h 55m05:30 PMPragueWilsonova Bus Station9:25 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 12/10/2025 5:30:00 PM to North Station, Brussels (Belgium) arriving at 12/11/2025 9:25:00 AM. 50 Economy ticket for $50 per person are available. Travel duration is 15h 55m
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FlixBus20h 10m09:55 PMPragueÚAN Florenc6:05 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 12/10/2025 9:55:00 PM to North Station, Brussels (Belgium) arriving at 12/11/2025 6:05:00 PM. 50 Economy ticket for $50 per person are available. Travel duration is 20h 10m
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FlixBus21h 5m09:40 AMPragueNa Knížecí Station6:45 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 12/10/2025 9:40:00 AM to North Station, Brussels (Belgium) arriving at 12/11/2025 6:45:00 AM. 50 Economy ticket for $50 per person are available. Travel duration is 21h 5m
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FlixBus21h 25m05:15 PMPragueWilsonova Bus Station2:40 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 12/10/2025 5:15:00 PM to North Station, Brussels (Belgium) arriving at 12/11/2025 2:40:00 PM. 50 Economy ticket for $50 per person are available. Travel duration is 21h 25m
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Smartwings25h 45m012:00 PMPrague AirportPrague Airport - T1/21:45 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Smartwings goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 12/10/2025 12:00:00 PM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/11/2025 1:45:00 PM. 50 Economy ticket for $229 per person are available. Travel duration is 25h 45m
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EasyJet Airline26h 20m011:25 AMPrague AirportPrague Airport - T1/21:45 PMAntwerp AirportAntwerp Airport0EconomyA Flight from EasyJet Airline goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 12/10/2025 11:25:00 AM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/11/2025 1:45:00 PM. 50 Economy ticket for $252 per person are available. Travel duration is 26h 20m
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Wizz Air29h 40m08:05 AMPrague AirportPrague Airport - T1/21:45 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Wizz Air goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 12/10/2025 8:05:00 AM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/11/2025 1:45:00 PM. 50 Economy ticket for $205 per person are available. Travel duration is 29h 40m
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Austrian Airlines30h 20m07:25 AMPrague AirportPrague Airport - T1/21:45 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Austrian Airlines goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 12/10/2025 7:25:00 AM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/11/2025 1:45:00 PM. 50 Economy ticket for $258 per person are available. Travel duration is 30h 20m
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Buzz31h 45m06:00 AMPrague AirportPrague Airport - T1/21:45 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Buzz goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 12/10/2025 6:00:00 AM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/11/2025 1:45:00 PM. 50 Economy ticket for $168 per person are available. Travel duration is 31h 45m
Fastest Buses Wednesday
Fastest Flights Wednesday
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FlixBus15h 25m06:00 PMPragueÚAN Florenc9:25 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 12/11/2025 6:00:00 PM to North Station, Brussels (Belgium) arriving at 12/12/2025 9:25:00 AM. 50 Economy ticket for $52 per person are available. Travel duration is 15h 25m
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European Sleeper15h 25m06:02 PMPragueWilsonova Bus Station9:27 AMBrusselsMidi Bus Station0EconomyA Bus from European Sleeper goes from Wilsonova Bus Station, Prague (Czech Republic) at 12/11/2025 6:02:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 12/12/2025 9:27:00 AM. 50 Economy ticket for $245 per person are available. Travel duration is 15h 25m
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FlixBus18h 15m010:15 PMPragueNa Knížecí Station4:30 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 12/11/2025 10:15:00 PM to North Station, Brussels (Belgium) arriving at 12/12/2025 4:30:00 PM. 50 Economy ticket for $52 per person are available. Travel duration is 18h 15m
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FlixBus18h 30m012:50 PMPragueHradčanská7:20 AMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from Hradčanská, Prague (Czech Republic) at 12/11/2025 12:50:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 12/12/2025 7:20:00 AM. 50 Economy ticket for $51 per person are available. Travel duration is 18h 30m
Fastest Buses Thursday
Here you will find all operators and timetables for a
Bus from Prague to Brussels
What are the most popular stations in Prague and Brussels?
In Prague, you will usually depart from Wilsonova Bus Station, ÚAN Florenc or Černý Most, while in Brussels you will be arriving at Midi Bus Station, North Station or Gare Centrale, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Brussels from Prague? With 6 connections between 4 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Prague and Brussels, you can pay as low as $50 with a Bus from FlixBus.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from Transavia Airlines: you will get to Brussels in just 10h 40m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Prague and Brussels are FlixBus, European Sleeper and Smartwings, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Prague and Brussels is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Horoměřice or to Saint-Gilles, and look at flights from Prague Airport, and landing at Brussels South Charleroi Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Prague to Brussels?
The most popular companies between Prague and Brussels, are FlixBus, European Sleeper and Smartwings. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus and European Sleeper
Airlines: Smartwings, Ryanair, EasyJet Airline and 6 more.
All you need to know when you travel from Prague to Brussels
Check all information on comfort and services on all modes of transports from Prague to Brussels. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Prague to Brussels
How can I reach Brussels from Prague?
Every day, there are on average 6 connections between Bus and Flight, with which you can get to Brussels from Prague.
How far is Brussels from Prague?
The distance between Prague and Brussels is 446.6 miles.
What is the most ecofriendly mode of transport between Prague and Brussels?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 19 kgs of CO2, a train 25 kgs, a car 122 kgs, and a flight 177 kgs.
What is the cheapest mode of transport from Prague to Brussels?
You can get to Brussels with just $50 by taking a Bus from FlixBus.
What is the fastest way to get from Prague to Brussels?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Brussels in just 10h 40m with a Flight from Transavia Airlines.
More routes to Prague and to Brussels
Looking for more options? Here you can see the most popular routes to Prague and to Brussels. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Prague
- Amsterdam to Prague
- Berlin to Prague
- Bern to Prague
- Bratislava to Prague
- Brno to Prague
- Chemnitz to Prague
- Dresden to Prague
- Florence to Prague
- Karlovy Vary to Prague
- Katowice to Prague
- Krakow to Prague
- Linz to Prague
- London to Prague
- Louny to Prague
- Lyon to Prague
- Memmingen to Prague
- Minsk to Prague
- Munich to Prague
- Nuremberg to Prague
- Paris to Prague
- Teplice to Prague
- Třebíč to Prague
- Vienna to Prague
- Zurich to Prague
- Trips to Brussels
- Aachen to Brussels
- Amsterdam to Brussels
- Antwerp to Brussels
- Barcelona to Brussels
- Berlin to Brussels
- Bordeaux to Brussels
- Bruges (BE) to Brussels
- Brussels South Charleroi Airport to Brussels
- Carcassonne to Brussels
- Ghent to Brussels
- Glasgow to Brussels
- Lisbon to Brussels
- London to Brussels
- Lyon to Brussels
- Milan to Brussels
- Munich to Brussels
- Münster to Brussels
- Paris to Brussels
- Porto to Brussels
- Rotterdam to Brussels
- Saarbruecken to Brussels
- Salzburg to Brussels
- Warsaw to Brussels
- Zurich to Brussels

