What is the best way to travel from Prague to Brussels?
Looking for a trip? Compare all the available Trains, Flights and Buses for the journey to Brussels from Prague. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 3 available companies to find your perfect trip!
What is the cheapest way to reach Brussels from Prague?
You can get to Brussels with just $17 by taking a Flight from Ryanair, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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FlixBus16h 10m09:45 PMPrague AirportPrague Airport - T1/21:55 PMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/2/2026 9:45:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 6/3/2026 1:55:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 16h 10m
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FlixBus15h 35m08:50 AMPrague AirportPrague Airport - T1/212:25 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/2/2026 8:50:00 AM to North Station, Brussels (Belgium) arriving at 6/3/2026 12:25:00 AM. 50 Economy ticket for $64 per person are available. Travel duration is 15h 35m
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FlixBus18h 0m01:20 PMPrague AirportPrague Airport - T1/27:20 AMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/2/2026 1:20:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 6/3/2026 7:20:00 AM. 50 Economy ticket for $64 per person are available. Travel duration is 18h 0m
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European Sleeper16h 30m06:00 PMPragueWilsonova Bus Station10:30 AMBrusselsMidi Bus Station0EconomyA Bus from European Sleeper goes from Wilsonova Bus Station, Prague (Czech Republic) at 6/2/2026 6:00:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 6/3/2026 10:30:00 AM. 50 Economy ticket for $245 per person are available. Travel duration is 16h 30m
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Skyscanner23h 50m01:00 PMPrague AirportPrague Airport - T1/212:50 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Skyscanner goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/2/2026 1:00:00 PM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 6/3/2026 12:50:00 PM. 50 Economy ticket for $155 per person are available. Travel duration is 23h 50m
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Ryanair22h 45m02:05 PMPrague AirportPrague Airport - T1/212:50 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Ryanair goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/2/2026 2:05:00 PM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 6/3/2026 12:50:00 PM. 50 Economy ticket for $156 per person are available. Travel duration is 22h 45m
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Buzz27h 5m09:45 AMPrague AirportPrague Airport - T1/212:50 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Buzz goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/2/2026 9:45:00 AM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 6/3/2026 12:50:00 PM. 50 Economy ticket for $170 per person are available. Travel duration is 27h 5m
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Wizz Air28h 5m08:45 AMPrague AirportPrague Airport - T1/212:50 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Wizz Air goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/2/2026 8:45:00 AM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 6/3/2026 12:50:00 PM. 50 Economy ticket for $180 per person are available. Travel duration is 28h 5m
Cheapest Buses Tuesday
Cheapest Flights Tuesday
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Ryanair1h 30m09:25 PMPrague AirportPrague Airport - T1/210:55 PMBrussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from Ryanair goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/3/2026 9:25:00 PM to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 6/3/2026 10:55:00 PM. 50 Economy ticket for $17 per person are available. Travel duration is 1h 30m
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Brussels Airlines1h 30m06:45 PMPrague AirportPrague Airport - T1/28:15 PMBrussels AirportBrussels Airport0EconomyA Flight from Brussels Airlines goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/3/2026 6:45:00 PM to Brussels Airport, Brussels Airport (Belgium) arriving at 6/3/2026 8:15:00 PM. 50 Economy ticket for $97 per person are available. Travel duration is 1h 30m
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Brussels Airlines1h 30m06:45 PMPrague AirportPrague Airport8:15 PMBrussels AirportBrussels Airport0EconomyA Flight from Brussels Airlines goes from Prague Airport, Prague Airport (Czech Republic) at 6/3/2026 6:45:00 PM to Brussels Airport, Brussels Airport (Belgium) arriving at 6/3/2026 8:15:00 PM. 50 Economy ticket for $109 per person are available. Travel duration is 1h 30m
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Brussels Airlines1h 30m06:50 AMPrague AirportPrague Airport - T1/28:20 AMBrussels AirportBrussels Airport0EconomyA Flight from Brussels Airlines goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/3/2026 6:50:00 AM to Brussels Airport, Brussels Airport (Belgium) arriving at 6/3/2026 8:20:00 AM. 50 Economy ticket for $205 per person are available. Travel duration is 1h 30m
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FlixBus14h 15m03:50 AMPragueWilsonova Bus Station6:05 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 6/3/2026 3:50:00 AM to North Station, Brussels (Belgium) arriving at 6/3/2026 6:05:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 14h 15m
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FlixBus13h 55m04:10 AMPragueNa Knížecí Station6:05 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 6/3/2026 4:10:00 AM to North Station, Brussels (Belgium) arriving at 6/3/2026 6:05:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 13h 55m
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FlixBus13h 20m011:05 AMPragueÚAN Florenc12:25 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 6/3/2026 11:05:00 AM to North Station, Brussels (Belgium) arriving at 6/4/2026 12:25:00 AM. 50 Economy ticket for $63 per person are available. Travel duration is 13h 20m
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FlixBus17h 0m01:45 AMPragueWilsonova Bus Station6:45 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 6/3/2026 1:45:00 AM to North Station, Brussels (Belgium) arriving at 6/3/2026 6:45:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 17h 0m
Cheapest Flights Wednesday
Cheapest Buses Wednesday
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Ryanair1h 30m02:35 PMPrague AirportPrague Airport - T1/24:05 PMBrussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from Ryanair goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/4/2026 2:35:00 PM to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 6/4/2026 4:05:00 PM. 50 Economy ticket for $37 per person are available. Travel duration is 1h 30m
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Smartwings1h 30m06:40 AMPrague AirportPrague Airport - T1/28:10 AMBrussels AirportBrussels Airport0EconomyA Flight from Smartwings goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/4/2026 6:40:00 AM to Brussels Airport, Brussels Airport (Belgium) arriving at 6/4/2026 8:10:00 AM. 50 Economy ticket for $96 per person are available. Travel duration is 1h 30m
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Smartwings1h 30m06:40 AMPrague AirportPrague Airport8:10 AMBrussels AirportBrussels Airport0EconomyA Flight from Smartwings goes from Prague Airport, Prague Airport (Czech Republic) at 6/4/2026 6:40:00 AM to Brussels Airport, Brussels Airport (Belgium) arriving at 6/4/2026 8:10:00 AM. 50 Economy ticket for $104 per person are available. Travel duration is 1h 30m
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Brussels Airlines1h 30m06:45 PMPrague AirportPrague Airport - T1/28:15 PMBrussels AirportBrussels Airport0EconomyA Flight from Brussels Airlines goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/4/2026 6:45:00 PM to Brussels Airport, Brussels Airport (Belgium) arriving at 6/4/2026 8:15:00 PM. 50 Economy ticket for $166 per person are available. Travel duration is 1h 30m
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FlixBus14h 15m03:50 AMPragueWilsonova Bus Station6:05 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 6/4/2026 3:50:00 AM to North Station, Brussels (Belgium) arriving at 6/4/2026 6:05:00 PM. 50 Economy ticket for $55 per person are available. Travel duration is 14h 15m
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FlixBus13h 55m04:10 AMPragueNa Knížecí Station6:05 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 6/4/2026 4:10:00 AM to North Station, Brussels (Belgium) arriving at 6/4/2026 6:05:00 PM. 50 Economy ticket for $55 per person are available. Travel duration is 13h 55m
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FlixBus13h 20m011:05 AMPragueÚAN Florenc12:25 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 6/4/2026 11:05:00 AM to North Station, Brussels (Belgium) arriving at 6/5/2026 12:25:00 AM. 50 Economy ticket for $55 per person are available. Travel duration is 13h 20m
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European Sleeper15h 27m06:00 PMPragueWilsonova Bus Station9:27 AMBrusselsMidi Bus Station0EconomyA Bus from European Sleeper goes from Wilsonova Bus Station, Prague (Czech Republic) at 6/4/2026 6:00:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 6/5/2026 9:27:00 AM. 50 Economy ticket for $280 per person are available. Travel duration is 15h 27m
Cheapest Flights Thursday
Cheapest Buses Thursday
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Ryanair1h 30m09:25 PMPrague AirportPrague Airport - T1/210:55 PMBrussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from Ryanair goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/5/2026 9:25:00 PM to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 6/5/2026 10:55:00 PM. 50 Economy ticket for $30 per person are available. Travel duration is 1h 30m
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Buzz5h 25m06:10 AMPrague AirportPrague Airport - T1/211:35 AMBrussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from Buzz goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/5/2026 6:10:00 AM to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 6/5/2026 11:35:00 AM. 50 Economy ticket for $111 per person are available. Travel duration is 5h 25m
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EasyJet Airline11h 40m09:55 PMPrague AirportPrague Airport9:35 AMBrussels AirportBrussels Airport0EconomyA Flight from EasyJet Airline goes from Prague Airport, Prague Airport (Czech Republic) at 6/5/2026 9:55:00 PM to Brussels Airport, Brussels Airport (Belgium) arriving at 6/6/2026 9:35:00 AM. 50 Economy ticket for $123 per person are available. Travel duration is 11h 40m
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Skyscanner10h 30m08:05 AMPrague AirportPrague Airport - T1/26:35 PMBrussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from Skyscanner goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/5/2026 8:05:00 AM to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 6/5/2026 6:35:00 PM. 50 Economy ticket for $142 per person are available. Travel duration is 10h 30m
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FlixBus13h 20m011:05 AMPragueÚAN Florenc12:25 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 6/5/2026 11:05:00 AM to North Station, Brussels (Belgium) arriving at 6/6/2026 12:25:00 AM. 50 Economy ticket for $62 per person are available. Travel duration is 13h 20m
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FlixBus14h 15m03:50 AMPragueWilsonova Bus Station6:05 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 6/5/2026 3:50:00 AM to North Station, Brussels (Belgium) arriving at 6/5/2026 6:05:00 PM. 50 Economy ticket for $63 per person are available. Travel duration is 14h 15m
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FlixBus13h 55m04:10 AMPragueNa Knížecí Station6:05 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 6/5/2026 4:10:00 AM to North Station, Brussels (Belgium) arriving at 6/5/2026 6:05:00 PM. 50 Economy ticket for $63 per person are available. Travel duration is 13h 55m
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FlixBus14h 50m011:05 PMPragueÚAN Florenc1:55 PMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 6/5/2026 11:05:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 6/6/2026 1:55:00 PM. 50 Economy ticket for $63 per person are available. Travel duration is 14h 50m
Cheapest Flights Friday
Cheapest Buses Friday
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FlixBus14h 15m03:50 AMPragueWilsonova Bus Station6:05 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 6/6/2026 3:50:00 AM to North Station, Brussels (Belgium) arriving at 6/6/2026 6:05:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 14h 15m
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FlixBus13h 55m04:10 AMPragueNa Knížecí Station6:05 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 6/6/2026 4:10:00 AM to North Station, Brussels (Belgium) arriving at 6/6/2026 6:05:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 13h 55m
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FlixBus13h 20m010:35 AMPragueÚAN Florenc11:55 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 6/6/2026 10:35:00 AM to North Station, Brussels (Belgium) arriving at 6/6/2026 11:55:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 13h 20m
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FlixBus17h 0m01:45 AMPragueWilsonova Bus Station6:45 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 6/6/2026 1:45:00 AM to North Station, Brussels (Belgium) arriving at 6/6/2026 6:45:00 PM. 50 Economy ticket for $65 per person are available. Travel duration is 17h 0m
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Brussels Airlines1h 30m06:50 AMPrague AirportPrague Airport8:20 AMBrussels AirportBrussels Airport0EconomyA Flight from Brussels Airlines goes from Prague Airport, Prague Airport (Czech Republic) at 6/6/2026 6:50:00 AM to Brussels Airport, Brussels Airport (Belgium) arriving at 6/6/2026 8:20:00 AM. 50 Economy ticket for $184 per person are available. Travel duration is 1h 30m
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Smartwings18h 35m06:00 PMPrague AirportPrague Airport12:35 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Smartwings goes from Prague Airport, Prague Airport (Czech Republic) at 6/6/2026 6:00:00 PM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 6/7/2026 12:35:00 PM. 50 Economy ticket for $239 per person are available. Travel duration is 18h 35m
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Brussels Airlines1h 30m011:50 AMPrague AirportPrague Airport1:20 PMBrussels AirportBrussels Airport0EconomyA Flight from Brussels Airlines goes from Prague Airport, Prague Airport (Czech Republic) at 6/6/2026 11:50:00 AM to Brussels Airport, Brussels Airport (Belgium) arriving at 6/6/2026 1:20:00 PM. 50 Economy ticket for $271 per person are available. Travel duration is 1h 30m
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Smartwings14h 40m06:00 AMPrague AirportPrague Airport8:40 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Smartwings goes from Prague Airport, Prague Airport (Czech Republic) at 6/6/2026 6:00:00 AM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 6/6/2026 8:40:00 PM. 50 Economy ticket for $411 per person are available. Travel duration is 14h 40m
Cheapest Buses Saturday
Cheapest Flights Saturday
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Ryanair9h 5m06:15 AMPrague AirportPrague Airport - T1/23:20 PMBrussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from Ryanair goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/7/2026 6:15:00 AM to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 6/7/2026 3:20:00 PM. 50 Economy ticket for $70 per person are available. Travel duration is 9h 5m
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Aegean Airlines1h 30m06:45 PMPrague AirportPrague Airport - T1/28:15 PMBrussels AirportBrussels Airport0EconomyA Flight from Aegean Airlines goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/7/2026 6:45:00 PM to Brussels Airport, Brussels Airport (Belgium) arriving at 6/7/2026 8:15:00 PM. 50 Economy ticket for $370 per person are available. Travel duration is 1h 30m
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Brussels Airlines1h 30m09:15 PMPrague AirportPrague Airport10:45 PMBrussels AirportBrussels Airport0EconomyA Flight from Brussels Airlines goes from Prague Airport, Prague Airport (Czech Republic) at 6/7/2026 9:15:00 PM to Brussels Airport, Brussels Airport (Belgium) arriving at 6/7/2026 10:45:00 PM. 50 Economy ticket for $395 per person are available. Travel duration is 1h 30m
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Smartwings27h 30m05:20 PMPrague AirportPrague Airport8:50 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Smartwings goes from Prague Airport, Prague Airport (Czech Republic) at 6/7/2026 5:20:00 PM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 6/8/2026 8:50:00 PM. 50 Economy ticket for $420 per person are available. Travel duration is 27h 30m
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FlixBus13h 20m011:05 AMPragueÚAN Florenc12:25 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 6/7/2026 11:05:00 AM to North Station, Brussels (Belgium) arriving at 6/8/2026 12:25:00 AM. 50 Economy ticket for $74 per person are available. Travel duration is 13h 20m
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FlixBus14h 35m09:50 AMPrague AirportPrague Airport - T1/212:25 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/7/2026 9:50:00 AM to North Station, Brussels (Belgium) arriving at 6/8/2026 12:25:00 AM. 50 Economy ticket for $78 per person are available. Travel duration is 14h 35m
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FlixBus18h 15m011:50 PMPragueWilsonova Bus Station6:05 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 6/7/2026 11:50:00 PM to North Station, Brussels (Belgium) arriving at 6/8/2026 6:05:00 PM. 50 Economy ticket for $81 per person are available. Travel duration is 18h 15m
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European Sleeper15h 27m06:00 PMPragueWilsonova Bus Station9:27 AMBrusselsMidi Bus Station0EconomyA Bus from European Sleeper goes from Wilsonova Bus Station, Prague (Czech Republic) at 6/7/2026 6:00:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 6/8/2026 9:27:00 AM. 50 Economy ticket for $349 per person are available. Travel duration is 15h 27m
Cheapest Flights Sunday
Cheapest Buses Sunday
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Ryanair1h 30m03:40 PMPrague AirportPrague Airport - T1/25:10 PMBrussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from Ryanair goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/8/2026 3:40:00 PM to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 6/8/2026 5:10:00 PM. 50 Economy ticket for $44 per person are available. Travel duration is 1h 30m
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Brussels Airlines1h 30m06:50 AMPrague AirportPrague Airport8:20 AMBrussels AirportBrussels Airport0EconomyA Flight from Brussels Airlines goes from Prague Airport, Prague Airport (Czech Republic) at 6/8/2026 6:50:00 AM to Brussels Airport, Brussels Airport (Belgium) arriving at 6/8/2026 8:20:00 AM. 50 Economy ticket for $226 per person are available. Travel duration is 1h 30m
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Skyscanner24h 25m01:30 PMPrague AirportPrague Airport - T1/21:55 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Skyscanner goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/8/2026 1:30:00 PM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 6/9/2026 1:55:00 PM. 50 Economy ticket for $234 per person are available. Travel duration is 24h 25m
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LC Perú28h 30m09:25 AMPrague AirportPrague Airport - T1/21:55 PMAntwerp AirportAntwerp Airport0EconomyA Flight from LC Perú goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/8/2026 9:25:00 AM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 6/9/2026 1:55:00 PM. 50 Economy ticket for $245 per person are available. Travel duration is 28h 30m
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FlixBus13h 20m011:05 AMPragueÚAN Florenc12:25 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 6/8/2026 11:05:00 AM to North Station, Brussels (Belgium) arriving at 6/9/2026 12:25:00 AM. 50 Economy ticket for $50 per person are available. Travel duration is 13h 20m
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FlixBus14h 50m011:05 PMPragueÚAN Florenc1:55 PMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 6/8/2026 11:05:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 6/9/2026 1:55:00 PM. 50 Economy ticket for $52 per person are available. Travel duration is 14h 50m
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FlixBus14h 15m03:50 AMPragueWilsonova Bus Station6:05 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 6/8/2026 3:50:00 AM to North Station, Brussels (Belgium) arriving at 6/8/2026 6:05:00 PM. 50 Economy ticket for $53 per person are available. Travel duration is 14h 15m
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FlixBus13h 55m04:10 AMPragueNa Knížecí Station6:05 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 6/8/2026 4:10:00 AM to North Station, Brussels (Belgium) arriving at 6/8/2026 6:05:00 PM. 50 Economy ticket for $53 per person are available. Travel duration is 13h 55m
Cheapest Flights Monday
Cheapest Buses Monday
What are the fastest trips from Prague to Brussels?
You can get to Brussels from Prague in just 1h 30m with a Flight from Ryanair. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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FlixBus15h 35m08:50 AMPrague AirportPrague Airport - T1/212:25 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/2/2026 8:50:00 AM to North Station, Brussels (Belgium) arriving at 6/3/2026 12:25:00 AM. 50 Economy ticket for $64 per person are available. Travel duration is 15h 35m
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FlixBus16h 10m09:45 PMPrague AirportPrague Airport - T1/21:55 PMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/2/2026 9:45:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 6/3/2026 1:55:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 16h 10m
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European Sleeper16h 30m06:00 PMPragueWilsonova Bus Station10:30 AMBrusselsMidi Bus Station0EconomyA Bus from European Sleeper goes from Wilsonova Bus Station, Prague (Czech Republic) at 6/2/2026 6:00:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 6/3/2026 10:30:00 AM. 50 Economy ticket for $245 per person are available. Travel duration is 16h 30m
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FlixBus18h 0m01:20 PMPrague AirportPrague Airport - T1/27:20 AMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/2/2026 1:20:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 6/3/2026 7:20:00 AM. 50 Economy ticket for $64 per person are available. Travel duration is 18h 0m
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Ryanair22h 45m02:05 PMPrague AirportPrague Airport - T1/212:50 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Ryanair goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/2/2026 2:05:00 PM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 6/3/2026 12:50:00 PM. 50 Economy ticket for $156 per person are available. Travel duration is 22h 45m
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Skyscanner23h 50m01:00 PMPrague AirportPrague Airport - T1/212:50 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Skyscanner goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/2/2026 1:00:00 PM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 6/3/2026 12:50:00 PM. 50 Economy ticket for $155 per person are available. Travel duration is 23h 50m
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Vueling Airlines26h 15m010:35 AMPrague AirportPrague Airport - T1/212:50 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Vueling Airlines goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/2/2026 10:35:00 AM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 6/3/2026 12:50:00 PM. 50 Economy ticket for $187 per person are available. Travel duration is 26h 15m
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Buzz27h 5m09:45 AMPrague AirportPrague Airport - T1/212:50 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Buzz goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/2/2026 9:45:00 AM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 6/3/2026 12:50:00 PM. 50 Economy ticket for $170 per person are available. Travel duration is 27h 5m
Fastest Buses Tuesday
Fastest Flights Tuesday
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Ryanair1h 30m09:25 PMPrague AirportPrague Airport - T1/210:55 PMBrussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from Ryanair goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/3/2026 9:25:00 PM to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 6/3/2026 10:55:00 PM. 50 Economy ticket for $17 per person are available. Travel duration is 1h 30m
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Brussels Airlines1h 30m06:45 PMPrague AirportPrague Airport - T1/28:15 PMBrussels AirportBrussels Airport0EconomyA Flight from Brussels Airlines goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/3/2026 6:45:00 PM to Brussels Airport, Brussels Airport (Belgium) arriving at 6/3/2026 8:15:00 PM. 50 Economy ticket for $97 per person are available. Travel duration is 1h 30m
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Brussels Airlines1h 30m06:45 PMPrague AirportPrague Airport8:15 PMBrussels AirportBrussels Airport0EconomyA Flight from Brussels Airlines goes from Prague Airport, Prague Airport (Czech Republic) at 6/3/2026 6:45:00 PM to Brussels Airport, Brussels Airport (Belgium) arriving at 6/3/2026 8:15:00 PM. 50 Economy ticket for $109 per person are available. Travel duration is 1h 30m
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Brussels Airlines1h 30m06:50 AMPrague AirportPrague Airport - T1/28:20 AMBrussels AirportBrussels Airport0EconomyA Flight from Brussels Airlines goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/3/2026 6:50:00 AM to Brussels Airport, Brussels Airport (Belgium) arriving at 6/3/2026 8:20:00 AM. 50 Economy ticket for $205 per person are available. Travel duration is 1h 30m
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FlixBus13h 20m011:05 AMPragueÚAN Florenc12:25 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 6/3/2026 11:05:00 AM to North Station, Brussels (Belgium) arriving at 6/4/2026 12:25:00 AM. 50 Economy ticket for $63 per person are available. Travel duration is 13h 20m
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FlixBus13h 55m04:10 AMPragueNa Knížecí Station6:05 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 6/3/2026 4:10:00 AM to North Station, Brussels (Belgium) arriving at 6/3/2026 6:05:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 13h 55m
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FlixBus14h 15m03:50 AMPragueWilsonova Bus Station6:05 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 6/3/2026 3:50:00 AM to North Station, Brussels (Belgium) arriving at 6/3/2026 6:05:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 14h 15m
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FlixBus15h 30m06:00 PMPragueÚAN Florenc9:30 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 6/3/2026 6:00:00 PM to North Station, Brussels (Belgium) arriving at 6/4/2026 9:30:00 AM. 50 Economy ticket for $64 per person are available. Travel duration is 15h 30m
Fastest Flights Wednesday
Fastest Buses Wednesday
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Ryanair1h 30m02:35 PMPrague AirportPrague Airport - T1/24:05 PMBrussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from Ryanair goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/4/2026 2:35:00 PM to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 6/4/2026 4:05:00 PM. 50 Economy ticket for $37 per person are available. Travel duration is 1h 30m
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Smartwings1h 30m06:40 AMPrague AirportPrague Airport - T1/28:10 AMBrussels AirportBrussels Airport0EconomyA Flight from Smartwings goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/4/2026 6:40:00 AM to Brussels Airport, Brussels Airport (Belgium) arriving at 6/4/2026 8:10:00 AM. 50 Economy ticket for $96 per person are available. Travel duration is 1h 30m
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Smartwings1h 30m06:40 AMPrague AirportPrague Airport8:10 AMBrussels AirportBrussels Airport0EconomyA Flight from Smartwings goes from Prague Airport, Prague Airport (Czech Republic) at 6/4/2026 6:40:00 AM to Brussels Airport, Brussels Airport (Belgium) arriving at 6/4/2026 8:10:00 AM. 50 Economy ticket for $104 per person are available. Travel duration is 1h 30m
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Brussels Airlines1h 30m06:45 PMPrague AirportPrague Airport - T1/28:15 PMBrussels AirportBrussels Airport0EconomyA Flight from Brussels Airlines goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/4/2026 6:45:00 PM to Brussels Airport, Brussels Airport (Belgium) arriving at 6/4/2026 8:15:00 PM. 50 Economy ticket for $166 per person are available. Travel duration is 1h 30m
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FlixBus13h 20m011:05 AMPragueÚAN Florenc12:25 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 6/4/2026 11:05:00 AM to North Station, Brussels (Belgium) arriving at 6/5/2026 12:25:00 AM. 50 Economy ticket for $55 per person are available. Travel duration is 13h 20m
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FlixBus13h 55m04:10 AMPragueNa Knížecí Station6:05 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 6/4/2026 4:10:00 AM to North Station, Brussels (Belgium) arriving at 6/4/2026 6:05:00 PM. 50 Economy ticket for $55 per person are available. Travel duration is 13h 55m
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FlixBus14h 15m03:50 AMPragueWilsonova Bus Station6:05 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 6/4/2026 3:50:00 AM to North Station, Brussels (Belgium) arriving at 6/4/2026 6:05:00 PM. 50 Economy ticket for $55 per person are available. Travel duration is 14h 15m
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European Sleeper15h 27m06:00 PMPragueWilsonova Bus Station9:27 AMBrusselsMidi Bus Station0EconomyA Bus from European Sleeper goes from Wilsonova Bus Station, Prague (Czech Republic) at 6/4/2026 6:00:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 6/5/2026 9:27:00 AM. 50 Economy ticket for $280 per person are available. Travel duration is 15h 27m
Fastest Flights Thursday
Fastest Buses Thursday
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Ryanair1h 30m09:25 PMPrague AirportPrague Airport - T1/210:55 PMBrussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from Ryanair goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/5/2026 9:25:00 PM to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 6/5/2026 10:55:00 PM. 50 Economy ticket for $30 per person are available. Travel duration is 1h 30m
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Buzz5h 25m06:10 AMPrague AirportPrague Airport - T1/211:35 AMBrussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from Buzz goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/5/2026 6:10:00 AM to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 6/5/2026 11:35:00 AM. 50 Economy ticket for $111 per person are available. Travel duration is 5h 25m
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R Airlines5h 25m010:05 AMPrague AirportPrague Airport - T1/23:30 PMBrussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from R Airlines goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/5/2026 10:05:00 AM to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 6/5/2026 3:30:00 PM. 50 Economy ticket for $159 per person are available. Travel duration is 5h 25m
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Skyscanner10h 30m08:05 AMPrague AirportPrague Airport - T1/26:35 PMBrussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from Skyscanner goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/5/2026 8:05:00 AM to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 6/5/2026 6:35:00 PM. 50 Economy ticket for $142 per person are available. Travel duration is 10h 30m
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FlixBus13h 20m011:05 AMPragueÚAN Florenc12:25 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 6/5/2026 11:05:00 AM to North Station, Brussels (Belgium) arriving at 6/6/2026 12:25:00 AM. 50 Economy ticket for $62 per person are available. Travel duration is 13h 20m
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FlixBus13h 55m04:10 AMPragueNa Knížecí Station6:05 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 6/5/2026 4:10:00 AM to North Station, Brussels (Belgium) arriving at 6/5/2026 6:05:00 PM. 50 Economy ticket for $63 per person are available. Travel duration is 13h 55m
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FlixBus14h 15m03:50 AMPragueWilsonova Bus Station6:05 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 6/5/2026 3:50:00 AM to North Station, Brussels (Belgium) arriving at 6/5/2026 6:05:00 PM. 50 Economy ticket for $63 per person are available. Travel duration is 14h 15m
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FlixBus14h 50m011:05 PMPragueÚAN Florenc1:55 PMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 6/5/2026 11:05:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 6/6/2026 1:55:00 PM. 50 Economy ticket for $63 per person are available. Travel duration is 14h 50m
Fastest Flights Friday
Fastest Buses Friday
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Brussels Airlines1h 30m06:50 AMPrague AirportPrague Airport8:20 AMBrussels AirportBrussels Airport0EconomyA Flight from Brussels Airlines goes from Prague Airport, Prague Airport (Czech Republic) at 6/6/2026 6:50:00 AM to Brussels Airport, Brussels Airport (Belgium) arriving at 6/6/2026 8:20:00 AM. 50 Economy ticket for $184 per person are available. Travel duration is 1h 30m
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Brussels Airlines1h 30m011:50 AMPrague AirportPrague Airport1:20 PMBrussels AirportBrussels Airport0EconomyA Flight from Brussels Airlines goes from Prague Airport, Prague Airport (Czech Republic) at 6/6/2026 11:50:00 AM to Brussels Airport, Brussels Airport (Belgium) arriving at 6/6/2026 1:20:00 PM. 50 Economy ticket for $271 per person are available. Travel duration is 1h 30m
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Smartwings14h 40m06:00 AMPrague AirportPrague Airport8:40 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Smartwings goes from Prague Airport, Prague Airport (Czech Republic) at 6/6/2026 6:00:00 AM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 6/6/2026 8:40:00 PM. 50 Economy ticket for $411 per person are available. Travel duration is 14h 40m
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Smartwings18h 35m06:00 PMPrague AirportPrague Airport12:35 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Smartwings goes from Prague Airport, Prague Airport (Czech Republic) at 6/6/2026 6:00:00 PM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 6/7/2026 12:35:00 PM. 50 Economy ticket for $239 per person are available. Travel duration is 18h 35m
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FlixBus13h 20m010:35 AMPragueÚAN Florenc11:55 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 6/6/2026 10:35:00 AM to North Station, Brussels (Belgium) arriving at 6/6/2026 11:55:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 13h 20m
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FlixBus13h 55m04:10 AMPragueNa Knížecí Station6:05 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 6/6/2026 4:10:00 AM to North Station, Brussels (Belgium) arriving at 6/6/2026 6:05:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 13h 55m
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FlixBus14h 15m03:50 AMPragueWilsonova Bus Station6:05 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 6/6/2026 3:50:00 AM to North Station, Brussels (Belgium) arriving at 6/6/2026 6:05:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 14h 15m
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FlixBus16h 0m05:30 PMPragueWilsonova Bus Station9:30 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 6/6/2026 5:30:00 PM to North Station, Brussels (Belgium) arriving at 6/7/2026 9:30:00 AM. 50 Economy ticket for $65 per person are available. Travel duration is 16h 0m
Fastest Flights Saturday
Fastest Buses Saturday
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Aegean Airlines1h 30m06:45 PMPrague AirportPrague Airport - T1/28:15 PMBrussels AirportBrussels Airport0EconomyA Flight from Aegean Airlines goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/7/2026 6:45:00 PM to Brussels Airport, Brussels Airport (Belgium) arriving at 6/7/2026 8:15:00 PM. 50 Economy ticket for $370 per person are available. Travel duration is 1h 30m
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Brussels Airlines1h 30m09:15 PMPrague AirportPrague Airport10:45 PMBrussels AirportBrussels Airport0EconomyA Flight from Brussels Airlines goes from Prague Airport, Prague Airport (Czech Republic) at 6/7/2026 9:15:00 PM to Brussels Airport, Brussels Airport (Belgium) arriving at 6/7/2026 10:45:00 PM. 50 Economy ticket for $395 per person are available. Travel duration is 1h 30m
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Brussels Airlines1h 30m06:45 PMPrague AirportPrague Airport8:15 PMBrussels AirportBrussels Airport0EconomyA Flight from Brussels Airlines goes from Prague Airport, Prague Airport (Czech Republic) at 6/7/2026 6:45:00 PM to Brussels Airport, Brussels Airport (Belgium) arriving at 6/7/2026 8:15:00 PM. 50 Economy ticket for $483 per person are available. Travel duration is 1h 30m
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Ryanair9h 5m06:15 AMPrague AirportPrague Airport - T1/23:20 PMBrussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from Ryanair goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/7/2026 6:15:00 AM to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 6/7/2026 3:20:00 PM. 50 Economy ticket for $70 per person are available. Travel duration is 9h 5m
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FlixBus13h 20m011:05 AMPragueÚAN Florenc12:25 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 6/7/2026 11:05:00 AM to North Station, Brussels (Belgium) arriving at 6/8/2026 12:25:00 AM. 50 Economy ticket for $74 per person are available. Travel duration is 13h 20m
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FlixBus14h 35m09:50 AMPrague AirportPrague Airport - T1/212:25 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/7/2026 9:50:00 AM to North Station, Brussels (Belgium) arriving at 6/8/2026 12:25:00 AM. 50 Economy ticket for $78 per person are available. Travel duration is 14h 35m
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European Sleeper15h 27m06:00 PMPragueWilsonova Bus Station9:27 AMBrusselsMidi Bus Station0EconomyA Bus from European Sleeper goes from Wilsonova Bus Station, Prague (Czech Republic) at 6/7/2026 6:00:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 6/8/2026 9:27:00 AM. 50 Economy ticket for $349 per person are available. Travel duration is 15h 27m
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FlixBus18h 15m011:50 PMPragueWilsonova Bus Station6:05 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 6/7/2026 11:50:00 PM to North Station, Brussels (Belgium) arriving at 6/8/2026 6:05:00 PM. 50 Economy ticket for $81 per person are available. Travel duration is 18h 15m
Fastest Flights Sunday
Fastest Buses Sunday
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Ryanair1h 30m03:40 PMPrague AirportPrague Airport - T1/25:10 PMBrussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from Ryanair goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/8/2026 3:40:00 PM to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 6/8/2026 5:10:00 PM. 50 Economy ticket for $44 per person are available. Travel duration is 1h 30m
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Brussels Airlines1h 30m06:50 AMPrague AirportPrague Airport8:20 AMBrussels AirportBrussels Airport0EconomyA Flight from Brussels Airlines goes from Prague Airport, Prague Airport (Czech Republic) at 6/8/2026 6:50:00 AM to Brussels Airport, Brussels Airport (Belgium) arriving at 6/8/2026 8:20:00 AM. 50 Economy ticket for $226 per person are available. Travel duration is 1h 30m
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Brussels Airlines1h 30m011:50 AMPrague AirportPrague Airport1:20 PMBrussels AirportBrussels Airport0EconomyA Flight from Brussels Airlines goes from Prague Airport, Prague Airport (Czech Republic) at 6/8/2026 11:50:00 AM to Brussels Airport, Brussels Airport (Belgium) arriving at 6/8/2026 1:20:00 PM. 50 Economy ticket for $273 per person are available. Travel duration is 1h 30m
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Brussels Airlines1h 30m06:50 AMPrague AirportPrague Airport - T1/28:20 AMBrussels AirportBrussels Airport0EconomyA Flight from Brussels Airlines goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 6/8/2026 6:50:00 AM to Brussels Airport, Brussels Airport (Belgium) arriving at 6/8/2026 8:20:00 AM. 50 Economy ticket for $364 per person are available. Travel duration is 1h 30m
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FlixBus13h 20m011:05 AMPragueÚAN Florenc12:25 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 6/8/2026 11:05:00 AM to North Station, Brussels (Belgium) arriving at 6/9/2026 12:25:00 AM. 50 Economy ticket for $50 per person are available. Travel duration is 13h 20m
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FlixBus13h 55m04:10 AMPragueNa Knížecí Station6:05 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 6/8/2026 4:10:00 AM to North Station, Brussels (Belgium) arriving at 6/8/2026 6:05:00 PM. 50 Economy ticket for $53 per person are available. Travel duration is 13h 55m
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FlixBus14h 15m03:50 AMPragueWilsonova Bus Station6:05 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 6/8/2026 3:50:00 AM to North Station, Brussels (Belgium) arriving at 6/8/2026 6:05:00 PM. 50 Economy ticket for $53 per person are available. Travel duration is 14h 15m
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FlixBus14h 50m011:05 PMPragueÚAN Florenc1:55 PMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 6/8/2026 11:05:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 6/9/2026 1:55:00 PM. 50 Economy ticket for $52 per person are available. Travel duration is 14h 50m
Fastest Flights Monday
Fastest Buses Monday
Here you will find all operators and timetables for a
Bus from Prague to Brussels
What are the most popular stations in Prague and Brussels?
In Prague, you will usually depart from Wilsonova Bus Station, ÚAN Florenc or Černý Most, while in Brussels you will be arriving at Midi Bus Station, North Station or Gare Centrale, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Brussels from Prague? With 13 connections between 3 Train, Flight and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Prague and Brussels, you can pay as low as $17 with a Flight from Ryanair.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from Ryanair: you will get to Brussels in just 1h 30m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Prague and Brussels are FlixBus, Brussels Airlines and Ryanair, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Prague and Brussels is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Horoměřice or to Saint-Gilles, and look at flights from Prague Airport, and landing at Brussels South Charleroi Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Prague to Brussels?
The most popular companies between Prague and Brussels, are FlixBus, Brussels Airlines and Ryanair. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus and European Sleeper
Airlines: Brussels Airlines, Ryanair, Smartwings and 11 more.
All you need to know when you travel from Prague to Brussels
Check all information on comfort and services on all modes of transports from Prague to Brussels. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Prague to Brussels
How can I reach Brussels from Prague?
Every day, there are on average 13 connections between Train, Flight and Bus, with which you can get to Brussels from Prague.
How far is Brussels from Prague?
The distance between Prague and Brussels is 446.6 miles.
What is the most ecofriendly mode of transport between Prague and Brussels?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 19 kgs of CO2, a train 25 kgs, a car 122 kgs, and a flight 177 kgs.
What is the cheapest mode of transport from Prague to Brussels?
You can get to Brussels with just $17 by taking a Flight from Ryanair.
What is the fastest way to get from Prague to Brussels?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Brussels in just 1h 30m with a Flight from Ryanair.
More routes to Prague and to Brussels
Looking for more options? Here you can see the most popular routes to Prague and to Brussels. Simply click on a connection, and you’ll find all the details about the route!
