What is the best way to travel from Prague to Brussels?
Looking for a trip? Compare all the available Carpool, Flights and Buses for the journey to Brussels from Prague. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
What is the cheapest way to reach Brussels from Prague?
You can get to Brussels with just $52 by taking a Flight from Ryanair, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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EasyJet Airline18h 10m01:15 PMPrague AirportPrague Airport - T1/27:25 AMBrussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from EasyJet Airline goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 11/5/2026 1:15:00 PM to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 11/6/2026 7:25:00 AM. 50 Economy ticket for $59 per person are available. Travel duration is 18h 10m
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Buzz15h 40m06:15 PMPrague AirportPrague Airport - T1/29:55 AMBrussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from Buzz goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 11/5/2026 6:15:00 PM to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 11/6/2026 9:55:00 AM. 50 Economy ticket for $71 per person are available. Travel duration is 15h 40m
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Ryanair14h 20m05:05 PMPrague AirportPrague Airport - T1/27:25 AMBrussels AirportBrussels Airport0EconomyA Flight from Ryanair goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 11/5/2026 5:05:00 PM to Brussels Airport, Brussels Airport (Belgium) arriving at 11/6/2026 7:25:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 14h 20m
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Ryanair14h 20m05:05 PMPrague AirportPrague Airport - T1/27:25 AMBrussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from Ryanair goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 11/5/2026 5:05:00 PM to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 11/6/2026 7:25:00 AM. 50 Economy ticket for $76 per person are available. Travel duration is 14h 20m
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FlixBus16h 55m08:50 AMPrague AirportPrague Airport - T1/21:45 AMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 11/5/2026 8:50:00 AM to Midi Bus Station, Brussels (Belgium) arriving at 11/6/2026 1:45:00 AM. 50 Economy ticket for $68 per person are available. Travel duration is 16h 55m
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FlixBus18h 0m01:20 PMPrague AirportPrague Airport - T1/27:20 AMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 11/5/2026 1:20:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 11/6/2026 7:20:00 AM. 50 Economy ticket for $69 per person are available. Travel duration is 18h 0m
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FlixBus17h 40m09:55 AMPragueZličín3:35 AMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from Zličín, Prague (Czech Republic) at 11/5/2026 9:55:00 AM to Midi Bus Station, Brussels (Belgium) arriving at 11/6/2026 3:35:00 AM. 50 Economy ticket for $72 per person are available. Travel duration is 17h 40m
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European Sleeper16h 27m06:00 PMPragueWilsonova Bus Station10:27 AMBrusselsMidi Bus Station0EconomyA Bus from European Sleeper goes from Wilsonova Bus Station, Prague (Czech Republic) at 11/5/2026 6:00:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 11/6/2026 10:27:00 AM. 50 Economy ticket for $276 per person are available. Travel duration is 16h 27m
Cheapest Flights Thursday
Cheapest Buses Thursday
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FlixBus14h 30m03:25 AMPragueWilsonova Bus Station5:55 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 11/6/2026 3:25:00 AM to North Station, Brussels (Belgium) arriving at 11/6/2026 5:55:00 PM. 50 Economy ticket for $66 per person are available. Travel duration is 14h 30m
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FlixBus14h 15m03:40 AMPragueNa Knížecí Station5:55 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 11/6/2026 3:40:00 AM to North Station, Brussels (Belgium) arriving at 11/6/2026 5:55:00 PM. 50 Economy ticket for $66 per person are available. Travel duration is 14h 15m
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FlixBus13h 30m011:00 AMPragueÚAN Florenc12:30 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 11/6/2026 11:00:00 AM to North Station, Brussels (Belgium) arriving at 11/7/2026 12:30:00 AM. 50 Economy ticket for $66 per person are available. Travel duration is 13h 30m
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FlixBus15h 40m08:50 AMPrague AirportPrague Airport - T1/212:30 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 11/6/2026 8:50:00 AM to North Station, Brussels (Belgium) arriving at 11/7/2026 12:30:00 AM. 50 Economy ticket for $69 per person are available. Travel duration is 15h 40m
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Ryanair14h 55m06:00 PMPrague AirportPrague Airport - T1/28:55 AMBrussels AirportBrussels Airport0EconomyA Flight from Ryanair goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 11/6/2026 6:00:00 PM to Brussels Airport, Brussels Airport (Belgium) arriving at 11/7/2026 8:55:00 AM. 50 Economy ticket for $69 per person are available. Travel duration is 14h 55m
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Eurowings14h 15m06:10 AMPrague AirportPrague Airport8:25 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Eurowings goes from Prague Airport, Prague Airport (Czech Republic) at 11/6/2026 6:10:00 AM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 11/6/2026 8:25:00 PM. 50 Economy ticket for $333 per person are available. Travel duration is 14h 15m
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Smartwings29h 15m04:30 PMPrague AirportPrague Airport9:45 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Smartwings goes from Prague Airport, Prague Airport (Czech Republic) at 11/6/2026 4:30:00 PM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 11/7/2026 9:45:00 PM. 50 Economy ticket for $552 per person are available. Travel duration is 29h 15m
Cheapest Buses Friday
Cheapest Flights Friday
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Ryanair13h 5m09:40 PMPrague AirportPrague Airport - T1/210:45 AMBrussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from Ryanair goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 11/7/2026 9:40:00 PM to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 11/8/2026 10:45:00 AM. 50 Economy ticket for $67 per person are available. Travel duration is 13h 5m
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FlixBus14h 30m03:25 AMPragueWilsonova Bus Station5:55 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 11/7/2026 3:25:00 AM to North Station, Brussels (Belgium) arriving at 11/7/2026 5:55:00 PM. 50 Economy ticket for $68 per person are available. Travel duration is 14h 30m
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FlixBus14h 15m03:40 AMPragueNa Knížecí Station5:55 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 11/7/2026 3:40:00 AM to North Station, Brussels (Belgium) arriving at 11/7/2026 5:55:00 PM. 50 Economy ticket for $68 per person are available. Travel duration is 14h 15m
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FlixBus13h 30m010:30 AMPragueÚAN Florenc12:00 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 11/7/2026 10:30:00 AM to North Station, Brussels (Belgium) arriving at 11/8/2026 12:00:00 AM. 50 Economy ticket for $68 per person are available. Travel duration is 13h 30m
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FlixBus15h 5m04:15 PMPragueÚAN Florenc7:20 AMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 11/7/2026 4:15:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 11/8/2026 7:20:00 AM. 50 Economy ticket for $71 per person are available. Travel duration is 15h 5m
Cheapest Flights Saturday
Cheapest Buses Saturday
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FlixBus14h 30m03:25 AMPragueWilsonova Bus Station5:55 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 11/8/2026 3:25:00 AM to North Station, Brussels (Belgium) arriving at 11/8/2026 5:55:00 PM. 50 Economy ticket for $68 per person are available. Travel duration is 14h 30m
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FlixBus14h 15m03:40 AMPragueNa Knížecí Station5:55 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 11/8/2026 3:40:00 AM to North Station, Brussels (Belgium) arriving at 11/8/2026 5:55:00 PM. 50 Economy ticket for $68 per person are available. Travel duration is 14h 15m
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FlixBus13h 30m09:45 AMPragueÚAN Florenc11:15 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 11/8/2026 9:45:00 AM to North Station, Brussels (Belgium) arriving at 11/8/2026 11:15:00 PM. 50 Economy ticket for $74 per person are available. Travel duration is 13h 30m
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European Sleeper16h 27m06:00 PMPragueWilsonova Bus Station10:27 AMBrusselsMidi Bus Station0EconomyA Bus from European Sleeper goes from Wilsonova Bus Station, Prague (Czech Republic) at 11/8/2026 6:00:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 11/9/2026 10:27:00 AM. 50 Economy ticket for $276 per person are available. Travel duration is 16h 27m
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Ryanair25h 20m06:15 AMPrague AirportPrague Airport - T1/27:35 AMBrussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from Ryanair goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 11/8/2026 6:15:00 AM to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 11/9/2026 7:35:00 AM. 50 Economy ticket for $87 per person are available. Travel duration is 25h 20m
Cheapest Buses Sunday
Cheapest Flights Sunday
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Ryanair1h 30m09:25 AMPrague AirportPrague Airport - T1/210:55 AMBrussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from Ryanair goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 11/9/2026 9:25:00 AM to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 11/9/2026 10:55:00 AM. 50 Economy ticket for $52 per person are available. Travel duration is 1h 30m
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Eurowings26h 35m011:05 AMPrague AirportPrague Airport1:40 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Eurowings goes from Prague Airport, Prague Airport (Czech Republic) at 11/9/2026 11:05:00 AM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 11/10/2026 1:40:00 PM. 50 Economy ticket for $322 per person are available. Travel duration is 26h 35m
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FlixBus18h 45m07:00 AMPrague AirportPrague Airport - T1/21:45 AMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 11/9/2026 7:00:00 AM to Midi Bus Station, Brussels (Belgium) arriving at 11/10/2026 1:45:00 AM. 50 Economy ticket for $57 per person are available. Travel duration is 18h 45m
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FlixBus20h 10m01:20 PMPrague AirportPrague Airport - T1/29:30 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 11/9/2026 1:20:00 PM to North Station, Brussels (Belgium) arriving at 11/10/2026 9:30:00 AM. 50 Economy ticket for $58 per person are available. Travel duration is 20h 10m
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FlixBus20h 40m01:20 PMPrague AirportPrague Airport - T1/210:00 AMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 11/9/2026 1:20:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 11/10/2026 10:00:00 AM. 50 Economy ticket for $58 per person are available. Travel duration is 20h 40m
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FlixBus15h 5m04:15 PMPragueÚAN Florenc7:20 AMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 11/9/2026 4:15:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 11/10/2026 7:20:00 AM. 50 Economy ticket for $60 per person are available. Travel duration is 15h 5m
Cheapest Flights Monday
Cheapest Buses Monday
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FlixBus14h 30m03:25 AMPragueWilsonova Bus Station5:55 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 11/10/2026 3:25:00 AM to North Station, Brussels (Belgium) arriving at 11/10/2026 5:55:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 14h 30m
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FlixBus14h 15m03:40 AMPragueNa Knížecí Station5:55 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 11/10/2026 3:40:00 AM to North Station, Brussels (Belgium) arriving at 11/10/2026 5:55:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 14h 15m
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FlixBus15h 5m04:15 PMPragueÚAN Florenc7:20 AMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 11/10/2026 4:15:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 11/11/2026 7:20:00 AM. 50 Economy ticket for $62 per person are available. Travel duration is 15h 5m
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European Sleeper16h 27m06:00 PMPragueWilsonova Bus Station10:27 AMBrusselsMidi Bus Station0EconomyA Bus from European Sleeper goes from Wilsonova Bus Station, Prague (Czech Republic) at 11/10/2026 6:00:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 11/11/2026 10:27:00 AM. 50 Economy ticket for $230 per person are available. Travel duration is 16h 27m
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Ryanair7h 50m01:40 PMPrague AirportPrague Airport - T1/29:30 PMBrussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from Ryanair goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 11/10/2026 1:40:00 PM to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 11/10/2026 9:30:00 PM. 50 Economy ticket for $123 per person are available. Travel duration is 7h 50m
Cheapest Buses Tuesday
Cheapest Flights Tuesday
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FlixBus19h 50m06:50 PMPrague AirportPrague Airport - T1/22:40 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 11/11/2026 6:50:00 PM to North Station, Brussels (Belgium) arriving at 11/12/2026 2:40:00 PM. 50 Economy ticket for $60 per person are available. Travel duration is 19h 50m
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FlixBus18h 45m08:50 AMPrague AirportPrague Airport - T1/23:35 AMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 11/11/2026 8:50:00 AM to Midi Bus Station, Brussels (Belgium) arriving at 11/12/2026 3:35:00 AM. 50 Economy ticket for $62 per person are available. Travel duration is 18h 45m
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FlixBus15h 5m04:15 PMPragueÚAN Florenc7:20 AMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 11/11/2026 4:15:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 11/12/2026 7:20:00 AM. 50 Economy ticket for $63 per person are available. Travel duration is 15h 5m
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FlixBus16h 0m05:30 PMPragueWilsonova Bus Station9:30 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 11/11/2026 5:30:00 PM to North Station, Brussels (Belgium) arriving at 11/12/2026 9:30:00 AM. 50 Economy ticket for $64 per person are available. Travel duration is 16h 0m
Cheapest Buses Wednesday
What are the fastest trips from Prague to Brussels?
You can get to Brussels from Prague in just 1h 30m with a Flight from Ryanair. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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Lufthansa3h 25m01:45 PMPrague AirportPrague Airport - T1/25:10 PMBrussels AirportBrussels Airport0EconomyA Flight from Lufthansa goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 11/5/2026 1:45:00 PM to Brussels Airport, Brussels Airport (Belgium) arriving at 11/5/2026 5:10:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 3h 25m
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SAS Scandinavian Airlines8h 0m010:40 AMPrague AirportPrague Airport - T1/26:40 PMBrussels AirportBrussels Airport0EconomyA Flight from SAS Scandinavian Airlines goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 11/5/2026 10:40:00 AM to Brussels Airport, Brussels Airport (Belgium) arriving at 11/5/2026 6:40:00 PM. 50 Economy ticket for $122 per person are available. Travel duration is 8h 0m
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Wizz Air11h 5m08:40 PMPrague AirportPrague Airport - T1/27:45 AMBrussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from Wizz Air goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 11/5/2026 8:40:00 PM to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 11/6/2026 7:45:00 AM. 50 Economy ticket for $89 per person are available. Travel duration is 11h 5m
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Ryanair14h 20m05:05 PMPrague AirportPrague Airport - T1/27:25 AMBrussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from Ryanair goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 11/5/2026 5:05:00 PM to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 11/6/2026 7:25:00 AM. 50 Economy ticket for $76 per person are available. Travel duration is 14h 20m
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European Sleeper16h 27m06:00 PMPragueWilsonova Bus Station10:27 AMBrusselsMidi Bus Station0EconomyA Bus from European Sleeper goes from Wilsonova Bus Station, Prague (Czech Republic) at 11/5/2026 6:00:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 11/6/2026 10:27:00 AM. 50 Economy ticket for $276 per person are available. Travel duration is 16h 27m
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FlixBus16h 55m08:50 AMPrague AirportPrague Airport - T1/21:45 AMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 11/5/2026 8:50:00 AM to Midi Bus Station, Brussels (Belgium) arriving at 11/6/2026 1:45:00 AM. 50 Economy ticket for $68 per person are available. Travel duration is 16h 55m
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FlixBus17h 40m09:55 AMPragueZličín3:35 AMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from Zličín, Prague (Czech Republic) at 11/5/2026 9:55:00 AM to Midi Bus Station, Brussels (Belgium) arriving at 11/6/2026 3:35:00 AM. 50 Economy ticket for $72 per person are available. Travel duration is 17h 40m
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FlixBus18h 0m01:20 PMPrague AirportPrague Airport - T1/27:20 AMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 11/5/2026 1:20:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 11/6/2026 7:20:00 AM. 50 Economy ticket for $69 per person are available. Travel duration is 18h 0m
Fastest Flights Thursday
Fastest Buses Thursday
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FlixBus13h 30m011:00 AMPragueÚAN Florenc12:30 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 11/6/2026 11:00:00 AM to North Station, Brussels (Belgium) arriving at 11/7/2026 12:30:00 AM. 50 Economy ticket for $66 per person are available. Travel duration is 13h 30m
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FlixBus14h 15m03:40 AMPragueNa Knížecí Station5:55 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 11/6/2026 3:40:00 AM to North Station, Brussels (Belgium) arriving at 11/6/2026 5:55:00 PM. 50 Economy ticket for $66 per person are available. Travel duration is 14h 15m
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FlixBus14h 30m03:25 AMPragueWilsonova Bus Station5:55 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 11/6/2026 3:25:00 AM to North Station, Brussels (Belgium) arriving at 11/6/2026 5:55:00 PM. 50 Economy ticket for $66 per person are available. Travel duration is 14h 30m
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FlixBus15h 40m08:50 AMPrague AirportPrague Airport - T1/212:30 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 11/6/2026 8:50:00 AM to North Station, Brussels (Belgium) arriving at 11/7/2026 12:30:00 AM. 50 Economy ticket for $69 per person are available. Travel duration is 15h 40m
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Eurowings14h 15m06:10 AMPrague AirportPrague Airport8:25 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Eurowings goes from Prague Airport, Prague Airport (Czech Republic) at 11/6/2026 6:10:00 AM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 11/6/2026 8:25:00 PM. 50 Economy ticket for $333 per person are available. Travel duration is 14h 15m
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Ryanair14h 55m06:00 PMPrague AirportPrague Airport - T1/28:55 AMBrussels AirportBrussels Airport0EconomyA Flight from Ryanair goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 11/6/2026 6:00:00 PM to Brussels Airport, Brussels Airport (Belgium) arriving at 11/7/2026 8:55:00 AM. 50 Economy ticket for $69 per person are available. Travel duration is 14h 55m
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Smartwings29h 15m04:30 PMPrague AirportPrague Airport9:45 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Smartwings goes from Prague Airport, Prague Airport (Czech Republic) at 11/6/2026 4:30:00 PM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 11/7/2026 9:45:00 PM. 50 Economy ticket for $552 per person are available. Travel duration is 29h 15m
Fastest Buses Friday
Fastest Flights Friday
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Ryanair13h 5m09:40 PMPrague AirportPrague Airport - T1/210:45 AMBrussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from Ryanair goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 11/7/2026 9:40:00 PM to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 11/8/2026 10:45:00 AM. 50 Economy ticket for $67 per person are available. Travel duration is 13h 5m
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FlixBus13h 30m010:30 AMPragueÚAN Florenc12:00 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 11/7/2026 10:30:00 AM to North Station, Brussels (Belgium) arriving at 11/8/2026 12:00:00 AM. 50 Economy ticket for $68 per person are available. Travel duration is 13h 30m
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FlixBus14h 15m03:40 AMPragueNa Knížecí Station5:55 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 11/7/2026 3:40:00 AM to North Station, Brussels (Belgium) arriving at 11/7/2026 5:55:00 PM. 50 Economy ticket for $68 per person are available. Travel duration is 14h 15m
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FlixBus14h 30m03:25 AMPragueWilsonova Bus Station5:55 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 11/7/2026 3:25:00 AM to North Station, Brussels (Belgium) arriving at 11/7/2026 5:55:00 PM. 50 Economy ticket for $68 per person are available. Travel duration is 14h 30m
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FlixBus14h 45m09:15 AMPrague AirportPrague Airport - T1/212:00 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 11/7/2026 9:15:00 AM to North Station, Brussels (Belgium) arriving at 11/8/2026 12:00:00 AM. 50 Economy ticket for $72 per person are available. Travel duration is 14h 45m
Fastest Flights Saturday
Fastest Buses Saturday
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FlixBus13h 30m09:45 AMPragueÚAN Florenc11:15 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 11/8/2026 9:45:00 AM to North Station, Brussels (Belgium) arriving at 11/8/2026 11:15:00 PM. 50 Economy ticket for $74 per person are available. Travel duration is 13h 30m
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FlixBus14h 15m03:40 AMPragueNa Knížecí Station5:55 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 11/8/2026 3:40:00 AM to North Station, Brussels (Belgium) arriving at 11/8/2026 5:55:00 PM. 50 Economy ticket for $68 per person are available. Travel duration is 14h 15m
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FlixBus14h 30m03:25 AMPragueWilsonova Bus Station5:55 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 11/8/2026 3:25:00 AM to North Station, Brussels (Belgium) arriving at 11/8/2026 5:55:00 PM. 50 Economy ticket for $68 per person are available. Travel duration is 14h 30m
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European Sleeper16h 27m06:00 PMPragueWilsonova Bus Station10:27 AMBrusselsMidi Bus Station0EconomyA Bus from European Sleeper goes from Wilsonova Bus Station, Prague (Czech Republic) at 11/8/2026 6:00:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 11/9/2026 10:27:00 AM. 50 Economy ticket for $276 per person are available. Travel duration is 16h 27m
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Ryanair25h 20m06:15 AMPrague AirportPrague Airport - T1/27:35 AMBrussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from Ryanair goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 11/8/2026 6:15:00 AM to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 11/9/2026 7:35:00 AM. 50 Economy ticket for $87 per person are available. Travel duration is 25h 20m
Fastest Buses Sunday
Fastest Flights Sunday
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Ryanair1h 30m09:25 AMPrague AirportPrague Airport - T1/210:55 AMBrussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from Ryanair goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 11/9/2026 9:25:00 AM to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 11/9/2026 10:55:00 AM. 50 Economy ticket for $52 per person are available. Travel duration is 1h 30m
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Eurowings26h 35m011:05 AMPrague AirportPrague Airport1:40 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Eurowings goes from Prague Airport, Prague Airport (Czech Republic) at 11/9/2026 11:05:00 AM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 11/10/2026 1:40:00 PM. 50 Economy ticket for $322 per person are available. Travel duration is 26h 35m
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FlixBus14h 30m03:25 AMPragueWilsonova Bus Station5:55 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 11/9/2026 3:25:00 AM to North Station, Brussels (Belgium) arriving at 11/9/2026 5:55:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 14h 30m
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FlixBus15h 5m04:15 PMPragueÚAN Florenc7:20 AMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 11/9/2026 4:15:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 11/10/2026 7:20:00 AM. 50 Economy ticket for $60 per person are available. Travel duration is 15h 5m
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FlixBus18h 45m07:00 AMPrague AirportPrague Airport - T1/21:45 AMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 11/9/2026 7:00:00 AM to Midi Bus Station, Brussels (Belgium) arriving at 11/10/2026 1:45:00 AM. 50 Economy ticket for $57 per person are available. Travel duration is 18h 45m
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FlixBus20h 10m01:20 PMPrague AirportPrague Airport - T1/29:30 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 11/9/2026 1:20:00 PM to North Station, Brussels (Belgium) arriving at 11/10/2026 9:30:00 AM. 50 Economy ticket for $58 per person are available. Travel duration is 20h 10m
Fastest Flights Monday
Fastest Buses Monday
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Ryanair7h 50m01:40 PMPrague AirportPrague Airport - T1/29:30 PMBrussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from Ryanair goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 11/10/2026 1:40:00 PM to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 11/10/2026 9:30:00 PM. 50 Economy ticket for $123 per person are available. Travel duration is 7h 50m
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FlixBus14h 15m03:40 AMPragueNa Knížecí Station5:55 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 11/10/2026 3:40:00 AM to North Station, Brussels (Belgium) arriving at 11/10/2026 5:55:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 14h 15m
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FlixBus14h 30m03:25 AMPragueWilsonova Bus Station5:55 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 11/10/2026 3:25:00 AM to North Station, Brussels (Belgium) arriving at 11/10/2026 5:55:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 14h 30m
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FlixBus15h 5m04:15 PMPragueÚAN Florenc7:20 AMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 11/10/2026 4:15:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 11/11/2026 7:20:00 AM. 50 Economy ticket for $62 per person are available. Travel duration is 15h 5m
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European Sleeper16h 27m06:00 PMPragueWilsonova Bus Station10:27 AMBrusselsMidi Bus Station0EconomyA Bus from European Sleeper goes from Wilsonova Bus Station, Prague (Czech Republic) at 11/10/2026 6:00:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 11/11/2026 10:27:00 AM. 50 Economy ticket for $230 per person are available. Travel duration is 16h 27m
Fastest Flights Tuesday
Fastest Buses Tuesday
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FlixBus15h 5m04:15 PMPragueÚAN Florenc7:20 AMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 11/11/2026 4:15:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 11/12/2026 7:20:00 AM. 50 Economy ticket for $63 per person are available. Travel duration is 15h 5m
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FlixBus16h 0m05:30 PMPragueWilsonova Bus Station9:30 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 11/11/2026 5:30:00 PM to North Station, Brussels (Belgium) arriving at 11/12/2026 9:30:00 AM. 50 Economy ticket for $64 per person are available. Travel duration is 16h 0m
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FlixBus18h 40m09:50 PMPragueNa Knížecí Station4:30 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 11/11/2026 9:50:00 PM to North Station, Brussels (Belgium) arriving at 11/12/2026 4:30:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 18h 40m
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FlixBus18h 45m08:50 AMPrague AirportPrague Airport - T1/23:35 AMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 11/11/2026 8:50:00 AM to Midi Bus Station, Brussels (Belgium) arriving at 11/12/2026 3:35:00 AM. 50 Economy ticket for $62 per person are available. Travel duration is 18h 45m
Fastest Buses Wednesday
Here you will find all operators and timetables for a
Bus from Prague to Brussels
What are the most popular stations in Prague and Brussels?
In Prague, you will usually depart from Wilsonova Bus Station, ÚAN Florenc or Roztyly, while in Brussels you will be arriving at North Station, Midi Bus Station or Gare Centrale, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Brussels from Prague? With 7 connections between 2 Carpool, Flight and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Prague and Brussels, you can pay as low as $52 with a Flight from Ryanair.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from Ryanair: you will get to Brussels in just 1h 30m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Prague and Brussels are FlixBus, Ryanair and European Sleeper, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Prague and Brussels is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Horoměřice or to Saint-Gilles, and look at flights from Prague Airport, and landing at Brussels South Charleroi Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Prague to Brussels?
The most popular companies between Prague and Brussels, are FlixBus, Ryanair and European Sleeper. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus and European Sleeper
Airlines: Ryanair, Eurowings, EasyJet Airline and 8 more.
All you need to know when you travel from Prague to Brussels
Check all information on comfort and services on all modes of transports from Prague to Brussels. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Prague to Brussels
How can I reach Brussels from Prague?
Every day, there are on average 7 connections between Carpool, Flight and Bus, with which you can get to Brussels from Prague.
How far is Brussels from Prague?
The distance between Prague and Brussels is 446.6 miles.
What is the most ecofriendly mode of transport between Prague and Brussels?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 19 kgs of CO2, a train 25 kgs, a car 122 kgs, and a flight 177 kgs.
What is the cheapest mode of transport from Prague to Brussels?
You can get to Brussels with just $52 by taking a Flight from Ryanair.
What is the fastest way to get from Prague to Brussels?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Brussels in just 1h 30m with a Flight from Ryanair.
More routes to Prague and to Brussels
Looking for more options? Here you can see the most popular routes to Prague and to Brussels. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Prague
- Amsterdam to Prague
- Berlin to Prague
- Bratislava to Prague
- Brno to Prague
- Budapest to Prague
- Cheb to Prague
- Dresden to Prague
- Dusseldorf to Prague
- Frankfurt am Main to Prague
- Hamburg to Prague
- Hanover to Prague
- Hradec Kralove to Prague
- Karlovy Vary to Prague
- Krakow to Prague
- London to Prague
- Manchester to Prague
- Munich to Prague
- Nuremberg to Prague
- Pilsen to Prague
- Prague Airport to Prague
- Presov to Prague
- Salzburg to Prague
- Venice to Prague
- Vienna to Prague
- Trips to Brussels
- Amsterdam to Brussels
- Antwerp to Brussels
- Basel to Brussels
- Berlin to Brussels
- Bern to Brussels
- Bremen to Brussels
- Brussels South Charleroi Airport to Brussels
- Budapest to Brussels
- Cologne/Bonn Airport to Brussels
- Dortmund to Brussels
- Essen to Brussels
- Genoa to Brussels
- Ghent to Brussels
- Hanover to Brussels
- Kassel to Brussels
- Lisbon to Brussels
- London to Brussels
- Lyon to Brussels
- Marseille to Brussels
- Milan to Brussels
- Paris to Brussels
- Salzburg to Brussels
- Venice to Brussels
- Vila Real to Brussels
