Bus Prague to Brussels: Compare prices and save money

Compare all timetables for the bus from Prague to Brussels

Here is a selection of the cheapest bus trips from the schedule from Prague to Brussels from various bus operators like FlixBus or European Sleeper for the next days.

today

$62

tomorrow

$67

Saturday

$53

Sunday

$66

Monday

$54

Tuesday

$52

Wednesday

$50

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	20h 10m	9:55 PM	Prague	ÚAN Florenc	6:05 PM	Brussels	North Station	Economy	$62	A Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 12/4/2025 9:55:00 PM to North Station, Brussels (Belgium) arriving at 12/5/2025 6:05:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 20h 10m
FlixBus	18h 15m	10:15 PM	Prague	Na Knížecí Station	4:30 PM	Brussels	North Station	Economy	$64	A Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 12/4/2025 10:15:00 PM to North Station, Brussels (Belgium) arriving at 12/5/2025 4:30:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 18h 15m
FlixBus	15h 55m	5:30 PM	Prague	Wilsonova Bus Station	9:25 AM	Brussels	North Station	Economy	$66	A Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 12/4/2025 5:30:00 PM to North Station, Brussels (Belgium) arriving at 12/5/2025 9:25:00 AM. 50 Economy ticket for $66 per person are available. Travel duration is 15h 55m
European Sleeper	15h 25m	6:02 PM	Prague	Wilsonova Bus Station	9:27 AM	Brussels	Midi Bus Station	Economy	$256	A Bus from European Sleeper goes from Wilsonova Bus Station, Prague (Czech Republic) at 12/4/2025 6:02:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 12/5/2025 9:27:00 AM. 50 Economy ticket for $256 per person are available. Travel duration is 15h 25m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	19h 20m	8:15 PM	Prague	ÚAN Florenc	3:35 PM	Brussels	Midi Bus Station	Economy	$67	A Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 12/5/2025 8:15:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 12/6/2025 3:35:00 PM. 50 Economy ticket for $67 per person are available. Travel duration is 19h 20m
FlixBus	18h 55m	8:40 PM	Prague	Na Knížecí Station	3:35 PM	Brussels	Midi Bus Station	Economy	$67	A Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 12/5/2025 8:40:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 12/6/2025 3:35:00 PM. 50 Economy ticket for $67 per person are available. Travel duration is 18h 55m
FlixBus	18h 50m	2:30 PM	Prague	Černý Most	9:20 AM	Brussels	North Station	Economy	$67	A Bus from FlixBus goes from Černý Most, Prague (Czech Republic) at 12/5/2025 2:30:00 PM to North Station, Brussels (Belgium) arriving at 12/6/2025 9:20:00 AM. 50 Economy ticket for $67 per person are available. Travel duration is 18h 50m
FlixBus	16h 5m	5:15 PM	Prague	ÚAN Florenc	9:20 AM	Brussels	North Station	Economy	$67	A Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 12/5/2025 5:15:00 PM to North Station, Brussels (Belgium) arriving at 12/6/2025 9:20:00 AM. 50 Economy ticket for $67 per person are available. Travel duration is 16h 5m
FlixBus	17h 0m	1:45 AM	Prague	Wilsonova Bus Station	6:45 PM	Brussels	North Station	Economy	$68	A Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 12/5/2025 1:45:00 AM to North Station, Brussels (Belgium) arriving at 12/5/2025 6:45:00 PM. 50 Economy ticket for $68 per person are available. Travel duration is 17h 0m

Did you know that if you travel from Prague to Brussels via Maastricht, you can save more than $8? You can find the corresponding connections below.
- FlixBus
  
  19h 45m
  
  0
  
  5:30 PM
  
  Prague
  Wilsonova Bus Station
  
  7:25 AM
  
  Maastricht
  Meerssenerweg
  
  0
  
  Economy
  
  $51
  
  A Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 12/5/2025 5:30:00 PM to Meerssenerweg, Maastricht (Netherlands) arriving at 12/6/2025 7:25:00 AM. 50 Economy ticket for $51 per person are available. Travel duration is 13h 55m
- FlixBus
  
  2h 20m
  
  0
  
  10:55 AM
  
  Maastricht
  Meerssenerweg
  
  1:15 PM
  
  Brussels
  North Station
  
  0
  
  Economy
  
  $9
  
  A Bus from FlixBus goes from Meerssenerweg, Maastricht (Netherlands) at 12/6/2025 10:55:00 AM to North Station, Brussels (Belgium) arriving at 12/6/2025 1:15:00 PM. 50 Economy ticket for $9 per person are available. Travel duration is 2h 20m
Travel time is 3h 40m longer, but you will save $8

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	17h 40m	1:05 PM	Prague	Wilsonova Bus Station	6:45 AM	Brussels	North Station	Economy	$53	A Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 12/6/2025 1:05:00 PM to North Station, Brussels (Belgium) arriving at 12/7/2025 6:45:00 AM. 50 Economy ticket for $53 per person are available. Travel duration is 17h 40m
FlixBus	17h 45m	2:45 PM	Prague	Wilsonova Bus Station	8:30 AM	Brussels	North Station	Economy	$53	A Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 12/6/2025 2:45:00 PM to North Station, Brussels (Belgium) arriving at 12/7/2025 8:30:00 AM. 50 Economy ticket for $53 per person are available. Travel duration is 17h 45m
FlixBus	17h 5m	3:45 PM	Prague	Wilsonova Bus Station	8:50 AM	Brussels	North Station	Economy	$53	A Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 12/6/2025 3:45:00 PM to North Station, Brussels (Belgium) arriving at 12/7/2025 8:50:00 AM. 50 Economy ticket for $53 per person are available. Travel duration is 17h 5m
FlixBus	15h 55m	5:30 PM	Prague	Wilsonova Bus Station	9:25 AM	Brussels	North Station	Economy	$53	A Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 12/6/2025 5:30:00 PM to North Station, Brussels (Belgium) arriving at 12/7/2025 9:25:00 AM. 50 Economy ticket for $53 per person are available. Travel duration is 15h 55m
FlixBus	15h 35m	5:45 PM	Prague	Na Knížecí Station	9:20 AM	Brussels	North Station	Economy	$53	A Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 12/6/2025 5:45:00 PM to North Station, Brussels (Belgium) arriving at 12/7/2025 9:20:00 AM. 50 Economy ticket for $53 per person are available. Travel duration is 15h 35m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	18h 25m	12:55 PM	Prague	Zličín	7:20 AM	Brussels	Midi Bus Station	Economy	$66	A Bus from FlixBus goes from Zličín, Prague (Czech Republic) at 12/7/2025 12:55:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 12/8/2025 7:20:00 AM. 50 Economy ticket for $66 per person are available. Travel duration is 18h 25m
FlixBus	19h 0m	5:45 PM	Prague	Na Knížecí Station	12:45 PM	Brussels	Midi Bus Station	Economy	$66	A Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 12/7/2025 5:45:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 12/8/2025 12:45:00 PM. 50 Economy ticket for $66 per person are available. Travel duration is 19h 0m
FlixBus	19h 40m	10:25 PM	Prague	Zličín	6:05 PM	Brussels	North Station	Economy	$66	A Bus from FlixBus goes from Zličín, Prague (Czech Republic) at 12/7/2025 10:25:00 PM to North Station, Brussels (Belgium) arriving at 12/8/2025 6:05:00 PM. 50 Economy ticket for $66 per person are available. Travel duration is 19h 40m
European Sleeper	15h 25m	6:02 PM	Prague	Wilsonova Bus Station	9:27 AM	Brussels	Midi Bus Station	Economy	$286	A Bus from European Sleeper goes from Wilsonova Bus Station, Prague (Czech Republic) at 12/7/2025 6:02:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 12/8/2025 9:27:00 AM. 50 Economy ticket for $286 per person are available. Travel duration is 15h 25m

Did you know that if you travel from Prague to Brussels via Cologne/Bonn Airport, you can save more than $15? You can find the corresponding connections below.
- RegioJet
  
  15h 40m
  
  0
  
  11:00 PM
  
  Prague
  ÚAN Florenc
  
  8:05 AM
  
  Cologne/Bonn Airport
  Cologne/Bonn Airport - Bus Station
  
  0
  
  Economy
  
  $35
  
  A Bus from RegioJet goes from ÚAN Florenc, Prague (Czech Republic) at 12/8/2025 11:00:00 PM to Cologne/Bonn Airport - Bus Station, Cologne/Bonn Airport (Germany) arriving at 12/9/2025 8:05:00 AM. 50 Economy ticket for $35 per person are available. Travel duration is 9h 5m
- FlixBus
  
  4h 30m
  
  0
  
  10:10 AM
  
  Cologne/Bonn Airport
  Cologne/Bonn Airport - Bus Station
  
  2:40 PM
  
  Brussels
  North Station
  
  0
  
  Economy
  
  $16
  
  A Bus from FlixBus goes from Cologne/Bonn Airport - Bus Station, Cologne/Bonn Airport (Germany) at 12/9/2025 10:10:00 AM to North Station, Brussels (Belgium) arriving at 12/9/2025 2:40:00 PM. 50 Economy ticket for $16 per person are available. Travel duration is 4h 30m
Travel time is 0h 15m longer, but you will save $15

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	20h 0m	10:15 PM	Prague	Na Knížecí Station	6:15 PM	Brussels	North Station	Economy	$54	A Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 12/8/2025 10:15:00 PM to North Station, Brussels (Belgium) arriving at 12/9/2025 6:15:00 PM. 50 Economy ticket for $54 per person are available. Travel duration is 20h 0m
FlixBus	17h 55m	12:50 PM	Prague	Hradčanská	6:45 AM	Brussels	North Station	Economy	$54	A Bus from FlixBus goes from Hradčanská, Prague (Czech Republic) at 12/8/2025 12:50:00 PM to North Station, Brussels (Belgium) arriving at 12/9/2025 6:45:00 AM. 50 Economy ticket for $54 per person are available. Travel duration is 17h 55m
FlixBus	16h 5m	5:15 PM	Prague	ÚAN Florenc	9:20 AM	Brussels	North Station	Economy	$54	A Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 12/8/2025 5:15:00 PM to North Station, Brussels (Belgium) arriving at 12/9/2025 9:20:00 AM. 50 Economy ticket for $54 per person are available. Travel duration is 16h 5m
FlixBus	18h 40m	8:00 PM	Prague	ÚAN Florenc	2:40 PM	Brussels	North Station	Economy	$54	A Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 12/8/2025 8:00:00 PM to North Station, Brussels (Belgium) arriving at 12/9/2025 2:40:00 PM. 50 Economy ticket for $54 per person are available. Travel duration is 18h 40m
FlixBus	17h 45m	4:15 PM	Prague	ÚAN Florenc	10:00 AM	Brussels	Midi Bus Station	Economy	$54	A Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 12/8/2025 4:15:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 12/9/2025 10:00:00 AM. 50 Economy ticket for $54 per person are available. Travel duration is 17h 45m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	21h 25m	5:15 PM	Prague	Wilsonova Bus Station	2:40 PM	Brussels	North Station	Economy	$52	A Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 12/9/2025 5:15:00 PM to North Station, Brussels (Belgium) arriving at 12/10/2025 2:40:00 PM. 50 Economy ticket for $52 per person are available. Travel duration is 21h 25m
FlixBus	18h 40m	8:00 PM	Prague	ÚAN Florenc	2:40 PM	Brussels	North Station	Economy	$52	A Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 12/9/2025 8:00:00 PM to North Station, Brussels (Belgium) arriving at 12/10/2025 2:40:00 PM. 50 Economy ticket for $52 per person are available. Travel duration is 18h 40m
FlixBus	21h 5m	9:40 AM	Prague	Na Knížecí Station	6:45 AM	Brussels	North Station	Economy	$52	A Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 12/9/2025 9:40:00 AM to North Station, Brussels (Belgium) arriving at 12/10/2025 6:45:00 AM. 50 Economy ticket for $52 per person are available. Travel duration is 21h 5m
European Sleeper	16h 37m	6:02 PM	Prague	Wilsonova Bus Station	10:39 AM	Brussels	Midi Bus Station	Economy	$310	A Bus from European Sleeper goes from Wilsonova Bus Station, Prague (Czech Republic) at 12/9/2025 6:02:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 12/10/2025 10:39:00 AM. 50 Economy ticket for $310 per person are available. Travel duration is 16h 37m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	21h 25m	5:15 PM	Prague	Wilsonova Bus Station	2:40 PM	Brussels	North Station	Economy	$50	A Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 12/10/2025 5:15:00 PM to North Station, Brussels (Belgium) arriving at 12/11/2025 2:40:00 PM. 50 Economy ticket for $50 per person are available. Travel duration is 21h 25m
FlixBus	15h 55m	5:30 PM	Prague	Wilsonova Bus Station	9:25 AM	Brussels	North Station	Economy	$50	A Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 12/10/2025 5:30:00 PM to North Station, Brussels (Belgium) arriving at 12/11/2025 9:25:00 AM. 50 Economy ticket for $50 per person are available. Travel duration is 15h 55m
FlixBus	15h 25m	6:00 PM	Prague	ÚAN Florenc	9:25 AM	Brussels	North Station	Economy	$50	A Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 12/10/2025 6:00:00 PM to North Station, Brussels (Belgium) arriving at 12/11/2025 9:25:00 AM. 50 Economy ticket for $50 per person are available. Travel duration is 15h 25m
FlixBus	20h 10m	9:55 PM	Prague	ÚAN Florenc	6:05 PM	Brussels	North Station	Economy	$50	A Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 12/10/2025 9:55:00 PM to North Station, Brussels (Belgium) arriving at 12/11/2025 6:05:00 PM. 50 Economy ticket for $50 per person are available. Travel duration is 20h 10m
FlixBus	21h 5m	9:40 AM	Prague	Na Knížecí Station	6:45 AM	Brussels	North Station	Economy	$50	A Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 12/10/2025 9:40:00 AM to North Station, Brussels (Belgium) arriving at 12/11/2025 6:45:00 AM. 50 Economy ticket for $50 per person are available. Travel duration is 21h 5m

Best Price Offer: The price for the cheapest bus from Prague to Brussels is $48 on 12/17/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between Prague and Brussels

See here how frequent the connections between Prague and Brussels are, during different times and days of the week.

Sunday is the busiest day, with more than 40 daily buses from Prague to Brussels. Tuesday has instead the fewest connections, with only 23 daily coaches between Prague and Brussels.

The busiest time of the day is the Afternoon, with 92 buses from Prague to Brussels, while Morning sees the fewest connections between Prague and Brussels, with 33 offers.

Facts about the bus from Prague to Brussels

Compare all providers like FlixBus and European Sleeper that travel 32 times every day by bus from Prague to Brussels in one click! Book your bus ticket from Prague to Brussels starting from $48!

Cheapest Bus	$48
Fastest Bus	13h 55m
Earliest Bus	3:50 AM
Latest Bus	10:15 PM
Daily Bus Routes	32 Ø
Distance	446.6 miles
Bus Companies	FlixBus and European Sleeper

Cheapest bus connections from Prague to Brussels

Every day, 32 buses from 2 bus companies leave Prague for Brussels: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/04/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 11/30

Monday 12/01

Tuesday 12/02

Wednesday 12/03

Thursday 12/04

$62

Friday 12/05

$67

Saturday 12/06

$53

Sunday 12/07

$66

Monday 12/08

$54

Tuesday 12/09

$52

Wednesday 12/10

$50

Thursday 12/11

$51

Friday 12/12

$55

Saturday 12/13

$51

Sunday 12/14

$58

Monday 12/15

$50

Tuesday 12/16

$49

Wednesday 12/17

$48

Thursday 12/18

$55

Friday 12/19

$68

Saturday 12/20

$73

Sunday 12/21

$79

Monday 12/22

$81

Tuesday 12/23

$89

Wednesday 12/24

$76

Thursday 12/25

$76

Friday 12/26

$79

Saturday 12/27

The cheapest time to travel from Prague to Brussels

See here on which day and which time of the day you can find the cheapest bus ticket from Prague to Brussels, for the next 30 days.

With a price starting from $48, Wednesday is the cheapest day for a bus from Prague to Brussels. Sunday instead is the most expensive day with prices starting from $58.

Night is the cheapest day time for bus tickets from Prague to Brussels, with $48. Morning is the most expensive time of the day with prices starting from $50.

How to save money travelling from Prague to Brussels

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Prague to Brussels in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Prague to Brussels, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Prague to Brussels are also emptier.

All bus stations and stops in Prague and Brussels

In the map below, you can see where to find all bus stations in Prague and Brussels.

Na Knížecí Station

Za Ženskými domovy / Ostrovského

ÚAN Florenc

Křižíkova 279

Wilsonova Bus Station

Wilsonova 300/8

Roztyly

Tomíčkova 2234

Černý Most

Bryksova

Midi Bus Station

Avenue Fonsny 1

North Station

Rue du Progrès 80

Congrès

Boulevard Pachéco 7

City Tours

Rue du Marché Aux Herbes 82

Delta

PONT DU, Boulevard des Invalides, 1160 BRUXELLES, Belgium

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Prague to Brussels? Compare all modes of transports from Prague to Brussels.

Service and Comfort on the bus from Prague to Brussels

Want to know which seat classes are available on the buses from Prague to Brussels? Or which bus companies serve the route Prague to Brussels? Below you will find answers to your questions.

FAQs about the Prague to Brussels bus

How much does a Prague Brussels bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $48 and takes 18h 15m to reach Brussels. Compare offers to save money!

How much could I save by comparing buses from Prague to Brussels?

This route is offered by 2 companies with a range of ticket prices between $48 and $310. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Brussels.

On average, how many connections are available from Prague to Brussels each day?

Every day, the Prague to Brussels bus route is served by approximately 32 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Prague to Brussels take?

The fastest bus from Prague to Brussels is offered by FlixBus and takes 13h 55m. Bus tickets for this connection cost $68. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Prague to Brussels?

The earliest bus arriving in Brussels from Prague starts at 3:50 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Prague to Brussels?

The latest bus trip departing from Prague for Brussels starts at 10:15 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Prague Brussels route?

When traveling by bus from Prague to Brussels, passengers can travel with FlixBus and European Sleeper. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Prague and Brussels?

You can check all the direct connections between Prague and Brussels by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and European Sleeper.

What can I take with me on the Prague to Brussels bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Prague Brussels bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Prague Brussels bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Prague to Brussels on your planned travel date.

Available seat classes which are offered on the bus route Prague to Brussels

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Prague and to Brussels

Here’s an overview of the most popular bus routes to Prague and to Brussels. Simply click on the connection of your choice, and you will find all the details about your bus route!