Bus from Prague to Brussels from $40

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Compare all timetables for the bus from Prague to Brussels

Here is a selection of the cheapest bus trips from the schedule from Prague to Brussels from various bus operators like FlixBus for the next days.
today
from $71
tomorrow
from $48
Tuesday
from $40
Wednesday
from $41
Thursday
from $45
Friday
from $65
Saturday
from $65

Cheapest bus trips today

Prices are for one way and one person
  • FlixBus
    15h 15m
    0
    11:05 PM
    Prague
    ÚAN Florenc
    2:20 PM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $71
  • FlixBus
    16h 5m
    0
    9:50 PM
    Prague
    Na Knížecí Station
    1:55 PM
    Brussels
    Midi Bus Station
    0
    FlixBus
    Economy
    $72
  • FlixBus
    19h 40m
    0
    10:25 PM
    Prague
    Zličín
    6:05 PM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $72
  • FlixBus
    16h 40m
    0
    4:45 PM
    Prague
    Wilsonova Bus Station
    9:25 AM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $73
  • FlixBus
    18h 25m
    0
    7:05 PM
    Prague
    Wilsonova Bus Station
    1:30 PM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $73
  • Did you know that if you travel from Prague to Brussels via Maastricht, you can save more than $22? You can find the corresponding connections below.
    • FlixBus
      15h 55m
      0
      5:30 PM
      Prague
      Wilsonova Bus Station
      7:25 AM
      Maastricht
      Meerssenerweg
      0
      FlixBus
      Economy
      $41
      • Waiting Time 0h 5m
    • FlixBus
      1h 55m
      0
      7:30 AM
      Maastricht
      Meerssenerweg
      9:25 AM
      Brussels
      North Station
      0
      FlixBus
      Economy
      $8
    Travel time is 0h 40m longer, but you will save $22

Cheapest bus trips tomorrow

Prices are for one way and one person
  • FlixBus
    18h 40m
    0
    3:50 AM
    Prague
    Wilsonova Bus Station
    10:30 PM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $48
  • FlixBus
    19h 45m
    0
    12:45 PM
    Prague
    Wilsonova Bus Station
    8:30 AM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $48
  • FlixBus
    15h 55m
    0
    5:30 PM
    Prague
    Wilsonova Bus Station
    9:25 AM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $48
  • FlixBus
    19h 35m
    0
    6:45 PM
    Prague
    Wilsonova Bus Station
    2:20 PM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $48
  • FlixBus
    15h 25m
    0
    6:00 PM
    Prague
    ÚAN Florenc
    9:25 AM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $48

Cheapest bus trips Tuesday

Prices are for one way and one person
  • FlixBus
    19h 45m
    0
    12:45 PM
    Prague
    Wilsonova Bus Station
    8:30 AM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $40
  • FlixBus
    19h 10m
    0
    3:05 PM
    Prague
    Zličín
    10:15 AM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $40
  • FlixBus
    17h 0m
    0
    1:45 AM
    Prague
    Wilsonova Bus Station
    6:45 PM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $41
  • FlixBus
    18h 40m
    0
    3:50 AM
    Prague
    Wilsonova Bus Station
    10:30 PM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $41
  • FlixBus
    15h 55m
    0
    5:30 PM
    Prague
    Wilsonova Bus Station
    9:25 AM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $41

Cheapest bus trips Wednesday

Prices are for one way and one person
  • FlixBus
    18h 15m
    0
    10:15 PM
    Prague
    Na Knížecí Station
    4:30 PM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $41
  • FlixBus
    15h 15m
    0
    11:05 PM
    Prague
    ÚAN Florenc
    2:20 PM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $42
  • FlixBus
    16h 30m
    0
    9:50 PM
    Prague
    Na Knížecí Station
    2:20 PM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $42
  • FlixBus
    17h 55m
    0
    12:50 PM
    Prague
    Hradčanská
    6:45 AM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $42
  • FlixBus
    18h 30m
    0
    12:50 PM
    Prague
    Hradčanská
    7:20 AM
    Brussels
    Midi Bus Station
    0
    FlixBus
    Economy
    $42

Cheapest bus trips Thursday

Prices are for one way and one person
  • FlixBus
    18h 30m
    0
    12:50 PM
    Prague
    Hradčanská
    7:20 AM
    Brussels
    Midi Bus Station
    0
    FlixBus
    Economy
    $45
  • FlixBus
    15h 55m
    0
    5:30 PM
    Prague
    Wilsonova Bus Station
    9:25 AM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $46
  • FlixBus
    18h 45m
    0
    6:45 PM
    Prague
    Wilsonova Bus Station
    1:30 PM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $46
  • FlixBus
    15h 25m
    0
    6:00 PM
    Prague
    ÚAN Florenc
    9:25 AM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $46
  • FlixBus
    14h 45m
    0
    7:30 PM
    Prague
    ÚAN Florenc
    10:15 AM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $46

Cheapest bus trips Friday

Prices are for one way and one person
  • FlixBus
    14h 15m
    0
    3:50 AM
    Prague
    Wilsonova Bus Station
    6:05 PM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $65
  • FlixBus
    13h 55m
    0
    4:10 AM
    Prague
    Na Knížecí Station
    6:05 PM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $65
  • FlixBus
    14h 50m
    0
    11:05 PM
    Prague
    ÚAN Florenc
    1:55 PM
    Brussels
    Midi Bus Station
    0
    FlixBus
    Economy
    $65
  • FlixBus
    15h 5m
    0
    4:15 PM
    Prague
    ÚAN Florenc
    7:20 AM
    Brussels
    Midi Bus Station
    0
    FlixBus
    Economy
    $73
  • FlixBus
    15h 15m
    0
    11:05 PM
    Prague
    ÚAN Florenc
    2:20 PM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $76
  • Did you know that if you travel from Prague to Brussels via Maastricht, you can save more than $18? You can find the corresponding connections below.
    • FlixBus
      16h 50m
      0
      2:30 PM
      Prague
      Černý Most
      4:45 AM
      Maastricht
      Meerssenerweg
      0
      FlixBus
      Economy
      $39
      • Waiting Time 0h 5m
    • FlixBus
      2h 30m
      0
      4:50 AM
      Maastricht
      Meerssenerweg
      7:20 AM
      Brussels
      Midi Bus Station
      0
      FlixBus
      Economy
      $9
    Travel time is 2h 55m longer, but you will save $18

Cheapest bus trips Saturday

Prices are for one way and one person
  • FlixBus
    14h 15m
    0
    3:50 AM
    Prague
    Wilsonova Bus Station
    6:05 PM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $65
  • FlixBus
    13h 55m
    0
    4:10 AM
    Prague
    Na Knížecí Station
    6:05 PM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $65
  • FlixBus
    15h 5m
    0
    4:15 PM
    Prague
    ÚAN Florenc
    7:20 AM
    Brussels
    Midi Bus Station
    0
    FlixBus
    Economy
    $67
  • FlixBus
    14h 50m
    0
    11:05 PM
    Prague
    ÚAN Florenc
    1:55 PM
    Brussels
    Midi Bus Station
    0
    FlixBus
    Economy
    $67
  • FlixBus
    18h 55m
    0
    2:30 PM
    Prague
    Černý Most
    9:25 AM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $69
  • Did you know that if you travel from Prague to Brussels via Maastricht, you can save more than $18? You can find the corresponding connections below.
    • FlixBus
      16h 50m
      0
      2:30 PM
      Prague
      Černý Most
      4:45 AM
      Maastricht
      Meerssenerweg
      0
      FlixBus
      Economy
      $39
      • Waiting Time 0h 5m
    • FlixBus
      2h 30m
      0
      4:50 AM
      Maastricht
      Meerssenerweg
      7:20 AM
      Brussels
      Midi Bus Station
      0
      FlixBus
      Economy
      $9
    Travel time is 2h 55m longer, but you will save $18

Frequency of bus connections between Prague and Brussels

See here how frequent the connections between Prague and Brussels are, during different times and days of the week.
Sunday is the busiest day, with more than 41 daily buses from Prague to Brussels. Tuesday has instead the fewest connections, with only 34 daily coaches between Prague and Brussels.
The busiest time of the day is the Afternoon, with 112 buses from Prague to Brussels, while Morning sees the fewest connections between Prague and Brussels, with 28 offers.

Facts about the bus from Prague to Brussels

Compare all providers like FlixBus that travel 38 times every day by bus from Prague to Brussels in one click! Book your bus ticket from Prague to Brussels starting from $40!

Cheapest Bus $40
Fastest Bus 13h 55m
Earliest Bus 1:45 AM
Latest Bus 11:05 PM
Daily Bus Routes 38 Ø
Distance 446.6 miles
Bus Companies FlixBus

Cheapest bus connections from Prague to Brussels

Every day, 38 buses from 1 bus companies leave Prague for Brussels: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 06/22/2025 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 06/22
$71
Monday 06/23
$48
Tuesday 06/24
$40
Wednesday 06/25
$41
Thursday 06/26
$45
Friday 06/27
$65
Saturday 06/28
$65
Sunday 06/29
$73
Monday 06/30
$55
Tuesday 07/01
$55
Wednesday 07/02
$52
Thursday 07/03
$67
Friday 07/04
$72
Saturday 07/05
$98
Sunday 07/06
$122
Monday 07/07
$94
Tuesday 07/08
$85
Wednesday 07/09
$60
Thursday 07/10
$62
Friday 07/11
$67
Saturday 07/12
$88
Sunday 07/13
$65
Monday 07/14
$56
Tuesday 07/15
$55
Wednesday 07/16
$55
Thursday 07/17
$58
Friday 07/18
$63
Saturday 07/19

The cheapest time to travel from Prague to Brussels

See here on which day and which time of the day you can find the cheapest bus ticket from Prague to Brussels, for the next 30 days.
With a price starting from $40, Tuesday is the cheapest day for a bus from Prague to Brussels. Sunday instead is the most expensive day with prices starting from $71.
Afternoon is the cheapest day time for bus tickets from Prague to Brussels, with $40. Morning is the most expensive time of the day with prices starting from $49.

How to save money travelling from Prague to Brussels

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Prague to Brussels in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Prague to Brussels, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Prague to Brussels are also emptier.

Beloved bus companies from Prague to Brussels

These are the most booked bus companies between Prague to Brussels from our users.

FlixBus from Prague to Brussels

FlixBus

Here you will find the key facts about the FlixBus bus route Prague to Brussels:

Cheapest Price $40
Fastest Bus 13h 55m
Earliest Bus 1:45 AM
Last Bus 11:05 PM
Daily Connections 38 Ø
Found on 6/21/2025

All bus stations and stops in Prague and Brussels

In the map below, you can see where to find all bus stations in Prague and Brussels.

Service and Comfort on the bus from Prague to Brussels

Want to know which seat classes are available on the buses from Prague to Brussels? Or which bus companies serve the route Prague to Brussels? Below you will find answers to your questions.

FAQs about the Prague to Brussels bus

How much does a Prague Brussels bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $40 and takes 19h 45m to reach Brussels. Compare offers to save money!

How much could I save by comparing buses from Prague to Brussels?

This route is offered by 1 companies with a range of ticket prices between $40 and $180. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Brussels.

On average, how many connections are available from Prague to Brussels each day?

Every day, the Prague to Brussels bus route is served by approximately 38 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Prague to Brussels take?

The fastest bus from Prague to Brussels is offered by FlixBus and takes 13h 55m. Bus tickets for this connection cost $83. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Prague to Brussels?

The earliest bus arriving in Brussels from Prague starts at 1:45 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Prague to Brussels?

The latest bus trip departing from Prague for Brussels starts at 11:05 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Prague Brussels route?

When traveling by bus from Prague to Brussels, passengers can travel with FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Prague and Brussels?

You can check all the direct connections between Prague and Brussels by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus.

What can I take with me on the Prague to Brussels bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Prague Brussels bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Prague Brussels bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Prague to Brussels on your planned travel date.

Available seat classes which are offered on the bus route Prague to Brussels

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Prague and to Brussels

Here’s an overview of the most popular bus routes to Prague and to Brussels. Simply click on the connection of your choice, and you will find all the details about your bus route!
From Warsaw to Prague bus From Warsaw to Prague bus
Bus from Pilsen to Prague Bus from Pilsen to Prague
Buses London - Prague Buses London - Prague
Bus Salzburg - Prague Bus Salzburg - Prague
Berlin to Brussels bus Berlin to Brussels bus
Bus from Charleroi to Brussels Bus from Charleroi to Brussels
Buses Dusseldorf - Brussels Buses Dusseldorf - Brussels
Buses from Cologne to Brussels Buses from Cologne to Brussels
Popular Airport Shuttles to Prague and to Brussels
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