Bus from Prague to Brussels from $49

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Compare all timetables for the bus from Prague to Brussels

Here is a selection of the cheapest bus trips from the schedule from Prague to Brussels from various bus operators like FlixBus or European Sleeper for the next days.

today
$61
tomorrow
$54
Wednesday
$49
Thursday
$54
Friday
$63
Saturday
$65
Sunday
$78

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 14h 50m 11:05 PM Prague ÚAN Florenc 1:55 PM Brussels Midi Bus Station  Economy $61
FlixBus 13h 30m 11:00 AM Prague ÚAN Florenc 12:30 AM Brussels North Station  Economy $63
FlixBus 15h 5m 4:15 PM Prague ÚAN Florenc 7:20 AM Brussels Midi Bus Station  Economy $71
FlixBus 16h 30m 5:45 PM Prague Na Knížecí Station 10:15 AM Brussels North Station  Economy $73
FlixBus 16h 50m 9:50 PM Prague Na Knížecí Station 2:40 PM Brussels North Station  Economy $73
  • Did you know that if you travel from Prague to Brussels via Cologne/Bonn Airport, you can save more than $8? You can find the corresponding connections below.
    • RegioJet
      14h 55m
      0
      11:00 PM
      Prague
      ÚAN Florenc
      8:05 AM
      Cologne/Bonn Airport
      Cologne/Bonn Airport - Bus Station
      0
      RegioJet
      Economy
      $37
      • Waiting Time 1h 10m
    • FlixBus
      4h 40m
      0
      9:15 AM
      Cologne/Bonn Airport
      Cologne/Bonn Airport - Bus Station
      1:55 PM
      Brussels
      Midi Bus Station
      0
      FlixBus
      Economy
      $16
    Travel time is 1h 25m longer, but you will save $8

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 16h 30m 5:45 PM Prague Na Knížecí Station 10:15 AM Brussels North Station  Economy $54
FlixBus 18h 5m 10:25 PM Prague Hradčanská 4:30 PM Brussels North Station  Economy $54
FlixBus 16h 0m 5:30 PM Prague Wilsonova Bus Station 9:30 AM Brussels North Station  Economy $55
European Sleeper 17h 28m 6:00 PM Prague Wilsonova Bus Station 11:28 AM Brussels Midi Bus Station  Economy $824

Cheapest bus trips Wednesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 18h 5m 11:50 PM Prague Wilsonova Bus Station 5:55 PM Brussels North Station  Economy $49
FlixBus 15h 35m 11:05 PM Prague ÚAN Florenc 2:40 PM Brussels North Station  Economy $49
FlixBus 18h 5m 10:25 PM Prague Hradčanská 4:30 PM Brussels North Station  Economy $49
FlixBus 16h 35m 9:10 AM Prague Na Knížecí Station 1:45 AM Brussels Midi Bus Station  Economy $50
FlixBus 19h 0m 5:45 PM Prague Na Knížecí Station 12:45 PM Brussels Midi Bus Station  Economy $50

Cheapest bus trips Thursday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 15h 5m 4:15 PM Prague ÚAN Florenc 7:20 AM Brussels Midi Bus Station  Economy $54
FlixBus 16h 0m 5:30 PM Prague Wilsonova Bus Station 9:30 AM Brussels North Station  Economy $55
FlixBus 15h 30m 6:00 PM Prague ÚAN Florenc 9:30 AM Brussels North Station  Economy $55
European Sleeper 17h 28m 6:00 PM Prague Wilsonova Bus Station 11:28 AM Brussels Midi Bus Station  Economy $217
  • Did you know that if you travel from Prague to Brussels via Cologne/Bonn Airport, you can save more than $5? You can find the corresponding connections below.
    • RegioJet
      20h 25m
      0
      11:00 PM
      Prague
      ÚAN Florenc
      8:05 AM
      Cologne/Bonn Airport
      Cologne/Bonn Airport - Bus Station
      0
      RegioJet
      Economy
      $33
      • Waiting Time 7h 30m
    • BlaBlaCar Bus
      3h 50m
      0
      3:35 PM
      Cologne/Bonn Airport
      Cologne/Bonn Airport - Bus Station
      7:25 PM
      Brussels
      Midi Bus Station
      0
      BlaBlaCar Bus
      Economy
      $16
    Travel time is 5h 20m longer, but you will save $5

Cheapest bus trips Friday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 14h 30m 3:25 AM Prague Wilsonova Bus Station 5:55 PM Brussels North Station  Economy $63
FlixBus 14h 15m 3:40 AM Prague Na Knížecí Station 5:55 PM Brussels North Station  Economy $63
FlixBus 14h 50m 11:05 PM Prague ÚAN Florenc 1:55 PM Brussels Midi Bus Station  Economy $65
FlixBus 13h 30m 11:00 AM Prague ÚAN Florenc 12:30 AM Brussels North Station  Economy $65
FlixBus 15h 5m 4:15 PM Prague ÚAN Florenc 7:20 AM Brussels Midi Bus Station  Economy $67
  • Did you know that if you travel from Prague to Brussels via Cologne/Bonn Airport, you can save more than $12? You can find the corresponding connections below.
    • RegioJet
      16h 40m
      0
      11:00 PM
      Prague
      ÚAN Florenc
      8:05 AM
      Cologne/Bonn Airport
      Cologne/Bonn Airport - Bus Station
      0
      RegioJet
      Economy
      $33
      • Waiting Time 3h 50m
    • BlaBlaCar Bus
      3h 45m
      0
      11:55 AM
      Cologne/Bonn Airport
      Cologne/Bonn Airport - Bus Station
      3:40 PM
      Brussels
      Midi Bus Station
      0
      BlaBlaCar Bus
      Economy
      $18
    Travel time is 3h 10m longer, but you will save $12

Cheapest bus trips Saturday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 14h 30m 3:25 AM Prague Wilsonova Bus Station 5:55 PM Brussels North Station  Economy $65
FlixBus 14h 15m 3:40 AM Prague Na Knížecí Station 5:55 PM Brussels North Station  Economy $65
FlixBus 15h 5m 4:15 PM Prague ÚAN Florenc 7:20 AM Brussels Midi Bus Station  Economy $65
FlixBus 14h 50m 11:05 PM Prague ÚAN Florenc 1:55 PM Brussels Midi Bus Station  Economy $67
FlixBus 13h 29m 10:30 AM Prague ÚAN Florenc 11:59 PM Brussels North Station  Economy $73
  • Did you know that if you travel from Prague to Brussels via Cologne/Bonn Airport, you can save more than $18? You can find the corresponding connections below.
    • RegioJet
      16h 40m
      0
      11:00 PM
      Prague
      ÚAN Florenc
      8:05 AM
      Cologne/Bonn Airport
      Cologne/Bonn Airport - Bus Station
      0
      RegioJet
      Economy
      $33
      • Waiting Time 3h 50m
    • BlaBlaCar Bus
      3h 45m
      0
      11:55 AM
      Cologne/Bonn Airport
      Cologne/Bonn Airport - Bus Station
      3:40 PM
      Brussels
      Midi Bus Station
      0
      BlaBlaCar Bus
      Economy
      $13
    Travel time is 3h 11m longer, but you will save $18

Cheapest bus trips Sunday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 14h 30m 3:25 AM Prague Wilsonova Bus Station 5:55 PM Brussels North Station  Economy $78
FlixBus 14h 15m 3:40 AM Prague Na Knížecí Station 5:55 PM Brussels North Station  Economy $78
FlixBus 14h 50m 11:05 PM Prague ÚAN Florenc 1:55 PM Brussels Midi Bus Station  Economy $81
European Sleeper 17h 45m 6:00 PM Prague Wilsonova Bus Station 11:45 AM Brussels Midi Bus Station  Economy $252
  • Did you know that if you travel from Prague to Brussels via Cologne/Bonn Airport, you can save more than $31? You can find the corresponding connections below.
    • RegioJet
      16h 40m
      0
      11:00 PM
      Prague
      ÚAN Florenc
      8:05 AM
      Cologne/Bonn Airport
      Cologne/Bonn Airport - Bus Station
      0
      RegioJet
      Economy
      $33
      • Waiting Time 3h 50m
    • BlaBlaCar Bus
      3h 45m
      0
      11:55 AM
      Cologne/Bonn Airport
      Cologne/Bonn Airport - Bus Station
      3:40 PM
      Brussels
      Midi Bus Station
      0
      BlaBlaCar Bus
      Economy
      $13
    Travel time is 2h 25m longer, but you will save $31

Best Price Offer: The price for the cheapest bus from Prague to Brussels is $49 on 10/14/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Prague and Brussels

See here how frequent the connections between Prague and Brussels are, during different times and days of the week.
Wednesday is the busiest day, with more than 38 daily buses from Prague to Brussels. Monday has instead the fewest connections, with only 32 daily coaches between Prague and Brussels.
The busiest time of the day is the Evening, with 97 buses from Prague to Brussels, while Night sees the fewest connections between Prague and Brussels, with 24 offers.

Facts about the bus from Prague to Brussels

Compare all providers like FlixBus and European Sleeper that travel 35 times every day by bus from Prague to Brussels in one click! Book your bus ticket from Prague to Brussels starting from $49!

Cheapest Bus $49
Fastest Bus 13h 29m
Earliest Bus 9:10 AM
Latest Bus 11:50 PM
Daily Bus Routes 35 Ø
Distance 446.6 miles
Bus Companies FlixBus and European Sleeper

Cheapest bus connections from Prague to Brussels

Every day, 35 buses from 2 bus companies leave Prague for Brussels: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 10/12/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 10/11
Monday 10/12
$61
Tuesday 10/13
$54
Wednesday 10/14
$49
Thursday 10/15
$54
Friday 10/16
$63
Saturday 10/17
$65
Sunday 10/18
$78
Monday 10/19
$56
Tuesday 10/20
$54
Wednesday 10/21
$53
Thursday 10/22
$54
Friday 10/23
$61
Saturday 10/24
$61
Sunday 10/25
$164
Monday 10/26
$63
Tuesday 10/27
$65
Wednesday 10/28
$67
Thursday 10/29
$67
Friday 10/30
$70
Saturday 10/31
$65
Sunday 11/01
$63
Monday 11/02
$53
Tuesday 11/03
$49
Wednesday 11/04
$49
Thursday 11/05
$49
Friday 11/06
$53
Saturday 11/07

The cheapest time to travel from Prague to Brussels

See here on which day and which time of the day you can find the cheapest bus ticket from Prague to Brussels, for the next 30 days.
With a price starting from $49, Wednesday is the cheapest day for a bus from Prague to Brussels. Sunday instead is the most expensive day with prices starting from $63.
Evening is the cheapest day time for bus tickets from Prague to Brussels, with $49. Afternoon is the most expensive time of the day with prices starting from $50.

How to save money travelling from Prague to Brussels

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Prague to Brussels in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Prague to Brussels, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Prague to Brussels are also emptier.

All bus stations and stops in Prague and Brussels

In the map below, you can see where to find all bus stations in Prague and Brussels.

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Prague to Brussels? Compare all modes of transports from Prague to Brussels.

Service and Comfort on the bus from Prague to Brussels

Want to know which seat classes are available on the buses from Prague to Brussels? Or which bus companies serve the route Prague to Brussels? Below you will find answers to your questions.

FAQs about the Prague to Brussels bus

How much does a Prague Brussels bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $49 and takes 15h 35m to reach Brussels. Compare offers to save money!

How much could I save by comparing buses from Prague to Brussels?

This route is offered by 2 companies with a range of ticket prices between $49 and $824. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Brussels.

On average, how many connections are available from Prague to Brussels each day?

Every day, the Prague to Brussels bus route is served by approximately 35 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Prague to Brussels take?

The fastest bus from Prague to Brussels is offered by FlixBus and takes 13h 29m. Bus tickets for this connection cost $73. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Prague to Brussels?

The earliest bus arriving in Brussels from Prague starts at 9:10 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Prague to Brussels?

The latest bus trip departing from Prague for Brussels starts at 11:50 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Prague Brussels route?

When traveling by bus from Prague to Brussels, passengers can travel with FlixBus and European Sleeper. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Prague and Brussels?

You can check all the direct connections between Prague and Brussels by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and European Sleeper.

What can I take with me on the Prague to Brussels bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Prague Brussels bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Prague Brussels bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Prague to Brussels on your planned travel date.

How does CheckMyBus find the best bus deals from Prague to Brussels?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 35 daily trips between Prague and Brussels. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Prague to Brussels?

Prices and availability for 35 trips between Prague and Brussels change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Prague to Brussels

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Prague and to Brussels

Here’s an overview of the most popular bus routes to Prague and to Brussels. Simply click on the connection of your choice, and you will find all the details about your bus route!
From Sibiu to Prague bus From Sibiu to Prague bus
From Trieste to Prague bus From Trieste to Prague bus
Bus Ternopil - Prague Bus Ternopil - Prague
Rome to Prague bus Rome to Prague bus
Buses Reading to Brussels Buses Reading to Brussels
Buses from Bologna to Brussels Buses from Bologna to Brussels
Buses Leipzig - Brussels Buses Leipzig - Brussels
Bus Lille to Brussels Bus Lille to Brussels
Popular Airport Shuttles to Prague and to Brussels
CheckMyBus › Buses in Czech Republic › Bus to Prague › Bus to Brussels

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