Bus from Milan to Brussels from $49

Compare 2 companies and find the best price with CheckMyBus
1
Search accommodation with Booking.com
The Best Deals Save up to 70%
The Most Choices Millions of routes worldwide
Easy and Transparent Compare offers with 1 click

Compare all timetables for the bus from Milan to Brussels

Here is a selection of the cheapest bus trips from the schedule from Milan to Brussels from various bus operators like FlixBus or BlaBlaCar Bus for the next days.
today
from $51
tomorrow
from $49
Thursday
from $54
Friday
from $64
Saturday
from $59
Sunday
from $68
Monday
from $51

Cheapest bus trips today

Prices are for one way and one person
  • FlixBus
    19h 0m
    0
    11:45 PM
    Milan
    Lampugnano Bus Station
    6:45 PM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $51
  • FlixBus
    15h 5m
    0
    5:25 PM
    Milan
    Lampugnano Bus Station
    8:30 AM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $57
  • FlixBus
    19h 50m
    0
    11:30 AM
    Milan
    Lampugnano Bus Station
    7:20 AM
    Brussels
    Midi Bus Station
    0
    FlixBus
    Economy
    $57
  • BlaBlaCar Bus
    12h 35m
    0
    7:55 PM
    Milan
    Lampugnano Bus Station
    8:30 AM
    Brussels
    Midi Bus Station
    0
    BlaBlaCar Bus
    Economy
    $64

Cheapest bus trips tomorrow

Prices are for one way and one person
  • FlixBus
    19h 0m
    0
    11:45 PM
    Milan
    Lampugnano Bus Station
    6:45 PM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $49
  • FlixBus
    19h 50m
    0
    11:30 AM
    Milan
    Lampugnano Bus Station
    7:20 AM
    Brussels
    Midi Bus Station
    0
    FlixBus
    Economy
    $52
  • FlixBus
    18h 25m
    0
    11:30 PM
    Milan
    Lampugnano Bus Station
    5:55 PM
    Brussels
    Midi Bus Station
    0
    FlixBus
    Economy
    $59
  • BlaBlaCar Bus
    18h 55m
    0
    8:00 PM
    Milan
    Lampugnano Bus Station
    2:55 PM
    Brussels
    Midi Bus Station
    0
    BlaBlaCar Bus
    Economy
    $70
  • BlaBlaCar Bus
    18h 55m
    0
    8:00 PM
    Milan
    Lampugnano Bus Station
    2:55 PM
    Brussels
    Midi Bus Station
    0
    BlaBlaCar Bus
    Economy
    $72

Cheapest bus trips Thursday

Prices are for one way and one person
  • FlixBus
    19h 10m
    0
    10:45 PM
    Milan
    Lampugnano Bus Station
    5:55 PM
    Brussels
    Midi Bus Station
    0
    FlixBus
    Economy
    $54
  • FlixBus
    18h 0m
    0
    10:45 PM
    Milan
    Lampugnano Bus Station
    4:45 PM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $55
  • FlixBus
    18h 30m
    0
    11:45 PM
    Milan
    Lampugnano Bus Station
    6:15 PM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $55
  • BlaBlaCar Bus
    16h 50m
    0
    5:50 PM
    Milan
    Lampugnano Bus Station
    10:40 AM
    Brussels
    Midi Bus Station
    0
    BlaBlaCar Bus
    Economy
    $70
  • BlaBlaCar Bus
    16h 50m
    0
    5:50 PM
    Milan
    Lampugnano Bus Station
    10:40 AM
    Brussels
    Midi Bus Station
    0
    BlaBlaCar Bus
    Economy
    $75

Cheapest bus trips Friday

Prices are for one way and one person
  • BlaBlaCar Bus
    13h 30m
    0
    3:20 PM
    Milan
    Lampugnano Bus Station
    4:50 AM
    Brussels
    Midi Bus Station
    0
    BlaBlaCar Bus
    Economy
    $64
  • BlaBlaCar Bus
    13h 30m
    0
    3:20 PM
    Milan
    Lampugnano Bus Station
    4:50 AM
    Brussels
    Midi Bus Station
    0
    BlaBlaCar Bus
    Economy
    $64
  • FlixBus
    13h 0m
    0
    7:40 PM
    Milan
    Lampugnano Bus Station
    8:40 AM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $78
  • FlixBus
    12h 50m
    0
    10:45 PM
    Milan
    Lampugnano Bus Station
    11:35 AM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $80
  • BlaBlaCar Bus
    12h 35m
    0
    7:55 PM
    Milan
    Lampugnano Bus Station
    8:30 AM
    Brussels
    Midi Bus Station
    0
    BlaBlaCar Bus
    Economy
    $81
  • Did you know that if you travel from Milan to Brussels via Mulhouse, you can save more than $14? You can find the corresponding connections below.
    • FlixBus
      17h 15m
      0
      9:05 PM
      Milan
      Lampugnano Bus Station
      2:50 AM
      Mulhouse
      Bus Station
      0
      FlixBus
      Economy
      $23
      • Waiting Time 0h 5m
    • FlixBus
      11h 25m
      0
      2:55 AM
      Mulhouse
      Bus Station
      2:20 PM
      Brussels
      North Station
      0
      FlixBus
      Economy
      $27
    Travel time is 4h 40m longer, but you will save $14

Cheapest bus trips Saturday

Prices are for one way and one person
  • BlaBlaCar Bus
    13h 30m
    0
    3:20 PM
    Milan
    Lampugnano Bus Station
    4:50 AM
    Brussels
    Midi Bus Station
    0
    BlaBlaCar Bus
    Economy
    $59
  • BlaBlaCar Bus
    13h 30m
    0
    3:20 PM
    Milan
    Lampugnano Bus Station
    4:50 AM
    Brussels
    Midi Bus Station
    0
    BlaBlaCar Bus
    Economy
    $59
  • BlaBlaCar Bus
    12h 35m
    0
    7:55 PM
    Milan
    Lampugnano Bus Station
    8:30 AM
    Brussels
    Midi Bus Station
    0
    BlaBlaCar Bus
    Economy
    $64
  • FlixBus
    13h 0m
    0
    7:40 PM
    Milan
    Lampugnano Bus Station
    8:40 AM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $68
  • FlixBus
    12h 50m
    0
    10:45 PM
    Milan
    Lampugnano Bus Station
    11:35 AM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $73
  • Did you know that if you travel from Milan to Brussels via Metz, you can save more than $11? You can find the corresponding connections below.
    • BlaBlaCar Bus
      12h 35m
      0
      7:55 PM
      Milan
      Lampugnano Bus Station
      4:55 AM
      Metz
      Bus Station
      0
      BlaBlaCar Bus
      Economy
      $31
      • Waiting Time 0h 5m
    • BlaBlaCar Bus
      3h 30m
      0
      5:00 AM
      Metz
      Bus Station
      8:30 AM
      Brussels
      Midi Bus Station
      0
      BlaBlaCar Bus
      Economy
      $16
    Travel time is the same as the direct connection, but you will save $11

Cheapest bus trips Sunday

Prices are for one way and one person
  • FlixBus
    13h 0m
    0
    7:40 PM
    Milan
    Lampugnano Bus Station
    8:40 AM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $68
  • BlaBlaCar Bus
    12h 35m
    0
    7:55 PM
    Milan
    Lampugnano Bus Station
    8:30 AM
    Brussels
    Midi Bus Station
    0
    BlaBlaCar Bus
    Economy
    $70
  • BlaBlaCar Bus
    12h 35m
    0
    7:55 PM
    Milan
    Lampugnano Bus Station
    8:30 AM
    Brussels
    Midi Bus Station
    0
    BlaBlaCar Bus
    Economy
    $70
  • FlixBus
    12h 50m
    0
    10:45 PM
    Milan
    Lampugnano Bus Station
    11:35 AM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $73
  • BlaBlaCar Bus
    17h 35m
    0
    11:55 PM
    Milan
    Lampugnano Bus Station
    5:30 PM
    Brussels
    Midi Bus Station
    0
    BlaBlaCar Bus
    Economy
    $75
  • Did you know that if you travel from Milan to Brussels via Metz, you can save more than $20? You can find the corresponding connections below.
    • BlaBlaCar Bus
      12h 35m
      0
      7:55 PM
      Milan
      Lampugnano Bus Station
      4:55 AM
      Metz
      Bus Station
      0
      BlaBlaCar Bus
      Economy
      $31
      • Waiting Time 0h 5m
    • BlaBlaCar Bus
      3h 30m
      0
      5:00 AM
      Metz
      Bus Station
      8:30 AM
      Brussels
      Midi Bus Station
      0
      BlaBlaCar Bus
      Economy
      $16
    Travel time is the same as the direct connection, but you will save $20

Cheapest bus trips Monday

Prices are for one way and one person
  • BlaBlaCar Bus
    13h 30m
    0
    3:20 PM
    Milan
    Lampugnano Bus Station
    4:50 AM
    Brussels
    Midi Bus Station
    0
    BlaBlaCar Bus
    Economy
    $51
  • BlaBlaCar Bus
    13h 30m
    0
    3:20 PM
    Milan
    Lampugnano Bus Station
    4:50 AM
    Brussels
    Midi Bus Station
    0
    BlaBlaCar Bus
    Economy
    $55
  • BlaBlaCar Bus
    12h 35m
    0
    7:55 PM
    Milan
    Lampugnano Bus Station
    8:30 AM
    Brussels
    Midi Bus Station
    0
    BlaBlaCar Bus
    Economy
    $56
  • FlixBus
    16h 0m
    0
    4:30 PM
    Milan
    Lampugnano Bus Station
    8:30 AM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $65
  • FlixBus
    13h 0m
    0
    7:40 PM
    Milan
    Lampugnano Bus Station
    8:40 AM
    Brussels
    North Station
    0
    FlixBus
    Economy
    $66

Frequency of bus connections between Milan and Brussels

See here how frequent the connections between Milan and Brussels are, during different times and days of the week.
Sunday is the busiest day, with more than 24 daily buses from Milan to Brussels. Monday has instead the fewest connections, with only 12 daily coaches between Milan and Brussels.
The busiest time of the day is the Evening, with 77 buses from Milan to Brussels, while Night sees the fewest connections between Milan and Brussels, with 6 offers.

Facts about the bus from Milan to Brussels

Compare all providers like FlixBus and BlaBlaCar Bus that travel 18 times every day by bus from Milan to Brussels in one click! Book your bus ticket from Milan to Brussels starting from $49!

Cheapest Bus $49
Fastest Bus 12h 35m
Earliest Bus 6:10 AM
Latest Bus 10:45 PM
Daily Bus Routes 18 Ø
Distance 433.6 miles
Bus Companies FlixBus and BlaBlaCar Bus

Cheapest bus connections from Milan to Brussels

Every day, 18 buses from 2 bus companies leave Milan for Brussels: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 06/25/2025 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 06/22
Monday 06/23
Tuesday 06/24
$51
Wednesday 06/25
$49
Thursday 06/26
$54
Friday 06/27
$64
Saturday 06/28
$59
Sunday 06/29
$70
Monday 06/30
$51
Tuesday 07/01
$56
Wednesday 07/02
$58
Thursday 07/03
$70
Friday 07/04
$70
Saturday 07/05
$64
Sunday 07/06
$70
Monday 07/07
$70
Tuesday 07/08
$68
Wednesday 07/09
$70
Thursday 07/10
$68
Friday 07/11
$70
Saturday 07/12
$60
Sunday 07/13
$70
Monday 07/14
$64
Tuesday 07/15
$66
Wednesday 07/16
$68
Thursday 07/17
$70
Friday 07/18
$64
Saturday 07/19

The cheapest time to travel from Milan to Brussels

See here on which day and which time of the day you can find the cheapest bus ticket from Milan to Brussels, for the next 30 days.
With a price starting from $49, Wednesday is the cheapest day for a bus from Milan to Brussels. Sunday instead is the most expensive day with prices starting from $68.
Evening is the cheapest day time for bus tickets from Milan to Brussels, with $49. Night is the most expensive time of the day with prices starting from $57.

How to save money travelling from Milan to Brussels

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Milan to Brussels in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Milan to Brussels, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Milan to Brussels are also emptier.

Beloved bus companies from Milan to Brussels

These are the most booked bus companies between Milan to Brussels from our users.

FlixBus from Milan to Brussels

FlixBus

Here you will find the key facts about the FlixBus bus route Milan to Brussels:

Cheapest Price $49
Fastest Bus 12h 50m
Earliest Bus 6:10 AM
Last Bus 10:45 PM
Daily Connections 10 Ø
Found on 6/24/2025

BlaBlaCar Bus from Milan to Brussels

BlaBlaCar Bus

Here you will find the key facts about the BlaBlaCar Bus bus route Milan to Brussels:

Cheapest Price $51
Fastest Bus 12h 35m
Earliest Bus 7:55 PM
Last Bus 7:55 PM
Daily Connections 8 Ø
Found on 6/24/2025

All bus stations and stops in Milan and Brussels

In the map below, you can see where to find all bus stations in Milan and Brussels.

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Milan to Brussels? Compare all modes of transports from Milan to Brussels.

Service and Comfort on the bus from Milan to Brussels

Want to know which seat classes are available on the buses from Milan to Brussels? Or which bus companies serve the route Milan to Brussels? Below you will find answers to your questions.

FAQs about the Milan to Brussels bus

How much does a Milan Brussels bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $49 and takes 19h 0m to reach Brussels. Compare offers to save money!

How much could I save by comparing buses from Milan to Brussels?

This route is offered by 2 companies with a range of ticket prices between $49 and $171. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Brussels.

On average, how many connections are available from Milan to Brussels each day?

Every day, the Milan to Brussels bus route is served by approximately 18 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Milan to Brussels take?

The fastest bus from Milan to Brussels is offered by BlaBlaCar Bus and takes 12h 35m. Bus tickets for this connection cost $64. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Milan to Brussels?

The earliest bus arriving in Brussels from Milan starts at 6:10 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Milan to Brussels?

The latest bus trip departing from Milan for Brussels starts at 10:45 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Milan Brussels route?

When traveling by bus from Milan to Brussels, passengers can travel with FlixBus and BlaBlaCar Bus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Milan and Brussels?

You can check all the direct connections between Milan and Brussels by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and BlaBlaCar Bus.

What can I take with me on the Milan to Brussels bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Milan Brussels bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Milan Brussels bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Milan to Brussels on your planned travel date.

Available seat classes which are offered on the bus route Milan to Brussels

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Milan and to Brussels

Here’s an overview of the most popular bus routes to Milan and to Brussels. Simply click on the connection of your choice, and you will find all the details about your bus route!
Buses from Pavia to Milan Buses from Pavia to Milan
Paris to Milan bus Paris to Milan bus
Venice to Milan bus Venice to Milan bus
Zurich to Milan bus Zurich to Milan bus
Bus to Brussels from Leuven Bus to Brussels from Leuven
Bus Zurich - Brussels Bus Zurich - Brussels
Buses Prague - Brussels Buses Prague - Brussels
Bus Rotterdam - Brussels Bus Rotterdam - Brussels
Popular Airport Shuttles to Milan and to Brussels
CheckMyBus › Buses in Italy › Bus to Milan › Bus to Brussels

The CheckMyBus App

Free Download

App Store
CheckMyBus App
Close
GPDR CheckMyBus shield

We value your privacy!

To show you the best bus offers, we and our partners use technical, analytical, and marketing cookies to personalize the ads. We remember your anonymized details to provide a personalized experience.