Bus Lyon to Brussels: Compare prices and save money

Compare all timetables for the bus from Lyon to Brussels

Here is a selection of the cheapest bus trips from the schedule from Lyon to Brussels from various bus operators like BlaBlaCar Bus or FlixBus for the next days.

today

$37

tomorrow

Thursday

$22

Friday

$26

Saturday

$30

Sunday

$24

Monday

$22

Cheapest bus trips today
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	BlaBlaCar Bus	12h 1m	11:59 PM	Lyon	Perrache Train Station	12:00 PM	Brussels	Midi Bus Station		Economy	$37	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 2/3/2026 11:59:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 2/4/2026 12:00:00 PM. 50 Economy ticket for $37 per person are available. Travel duration is 12h 1m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
BlaBlaCar Bus	10h 50m	2:40 AM	Lyon	Perrache Train Station	1:30 PM	Brussels	Midi Bus Station	Economy	$22	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 2/5/2026 2:40:00 AM to Midi Bus Station, Brussels (Belgium) arriving at 2/5/2026 1:30:00 PM. 50 Economy ticket for $22 per person are available. Travel duration is 10h 50m
BlaBlaCar Bus	12h 55m	10:40 AM	Lyon	Perrache Train Station	11:35 PM	Brussels	Midi Bus Station	Economy	$25	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 2/5/2026 10:40:00 AM to Midi Bus Station, Brussels (Belgium) arriving at 2/5/2026 11:35:00 PM. 50 Economy ticket for $25 per person are available. Travel duration is 12h 55m
BlaBlaCar Bus	11h 15m	6:15 AM	Lyon	Perrache Train Station	5:30 PM	Brussels	Midi Bus Station	Economy	$27	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 2/5/2026 6:15:00 AM to Midi Bus Station, Brussels (Belgium) arriving at 2/5/2026 5:30:00 PM. 50 Economy ticket for $27 per person are available. Travel duration is 11h 15m
BlaBlaCar Bus	11h 25m	8:30 AM	Lyon	Perrache Train Station	7:55 PM	Brussels	North Station	Economy	$32	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 2/5/2026 8:30:00 AM to North Station, Brussels (Belgium) arriving at 2/5/2026 7:55:00 PM. 50 Economy ticket for $32 per person are available. Travel duration is 11h 25m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
BlaBlaCar Bus	10h 15m	6:15 AM	Lyon	Perrache Train Station	4:30 PM	Brussels	Midi Bus Station	Economy	$26	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 2/6/2026 6:15:00 AM to Midi Bus Station, Brussels (Belgium) arriving at 2/6/2026 4:30:00 PM. 50 Economy ticket for $26 per person are available. Travel duration is 10h 15m
BlaBlaCar Bus	10h 50m	2:40 AM	Lyon	Perrache Train Station	1:30 PM	Brussels	Midi Bus Station	Economy	$34	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 2/6/2026 2:40:00 AM to Midi Bus Station, Brussels (Belgium) arriving at 2/6/2026 1:30:00 PM. 50 Economy ticket for $34 per person are available. Travel duration is 10h 50m
BlaBlaCar Bus	11h 25m	8:30 AM	Lyon	Perrache Train Station	7:55 PM	Brussels	North Station	Economy	$35	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 2/6/2026 8:30:00 AM to North Station, Brussels (Belgium) arriving at 2/6/2026 7:55:00 PM. 50 Economy ticket for $35 per person are available. Travel duration is 11h 25m
BlaBlaCar Bus	11h 35m	12:00 PM	Lyon	Perrache Train Station	11:35 PM	Brussels	Midi Bus Station	Economy	$37	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 2/6/2026 12:00:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 2/6/2026 11:35:00 PM. 50 Economy ticket for $37 per person are available. Travel duration is 11h 35m
BlaBlaCar Bus	11h 30m	12:30 AM	Lyon	Perrache Train Station	12:00 PM	Brussels	Midi Bus Station	Economy	$44	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 2/6/2026 12:30:00 AM to Midi Bus Station, Brussels (Belgium) arriving at 2/6/2026 12:00:00 PM. 50 Economy ticket for $44 per person are available. Travel duration is 11h 30m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
BlaBlaCar Bus	11h 35m	12:00 PM	Lyon	Perrache Train Station	11:35 PM	Brussels	Midi Bus Station	Economy	$30	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 2/7/2026 12:00:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 2/7/2026 11:35:00 PM. 50 Economy ticket for $30 per person are available. Travel duration is 11h 35m
BlaBlaCar Bus	11h 25m	8:30 AM	Lyon	Perrache Train Station	7:55 PM	Brussels	North Station	Economy	$35	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 2/7/2026 8:30:00 AM to North Station, Brussels (Belgium) arriving at 2/7/2026 7:55:00 PM. 50 Economy ticket for $35 per person are available. Travel duration is 11h 25m
BlaBlaCar Bus	10h 25m	1:35 AM	Lyon	Perrache Train Station	12:00 PM	Brussels	Midi Bus Station	Economy	$57	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 2/7/2026 1:35:00 AM to Midi Bus Station, Brussels (Belgium) arriving at 2/7/2026 12:00:00 PM. 50 Economy ticket for $57 per person are available. Travel duration is 10h 25m
BlaBlaCar Bus	11h 5m	2:25 AM	Lyon	Perrache Train Station	1:30 PM	Brussels	Midi Bus Station	Economy	$136	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 2/7/2026 2:25:00 AM to Midi Bus Station, Brussels (Belgium) arriving at 2/7/2026 1:30:00 PM. 50 Economy ticket for $136 per person are available. Travel duration is 11h 5m
BlaBlaCar Bus	9h 40m	10:45 PM	Lyon	Perrache Train Station	8:25 AM	Brussels	Midi Bus Station	Economy	$165	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 2/7/2026 10:45:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 2/8/2026 8:25:00 AM. 50 Economy ticket for $165 per person are available. Travel duration is 9h 40m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
BlaBlaCar Bus	10h 50m	2:40 AM	Lyon	Perrache Train Station	1:30 PM	Brussels	Midi Bus Station	Economy	$24	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 2/8/2026 2:40:00 AM to Midi Bus Station, Brussels (Belgium) arriving at 2/8/2026 1:30:00 PM. 50 Economy ticket for $24 per person are available. Travel duration is 10h 50m
BlaBlaCar Bus	10h 15m	6:15 AM	Lyon	Perrache Train Station	4:30 PM	Brussels	Midi Bus Station	Economy	$30	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 2/8/2026 6:15:00 AM to Midi Bus Station, Brussels (Belgium) arriving at 2/8/2026 4:30:00 PM. 50 Economy ticket for $30 per person are available. Travel duration is 10h 15m
BlaBlaCar Bus	9h 40m	10:45 PM	Lyon	Perrache Train Station	8:25 AM	Brussels	Midi Bus Station	Economy	$32	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 2/8/2026 10:45:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 2/9/2026 8:25:00 AM. 50 Economy ticket for $32 per person are available. Travel duration is 9h 40m
BlaBlaCar Bus	10h 25m	1:35 AM	Lyon	Perrache Train Station	12:00 PM	Brussels	Midi Bus Station	Economy	$37	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 2/8/2026 1:35:00 AM to Midi Bus Station, Brussels (Belgium) arriving at 2/8/2026 12:00:00 PM. 50 Economy ticket for $37 per person are available. Travel duration is 10h 25m
BlaBlaCar Bus	11h 35m	12:00 PM	Lyon	Perrache Train Station	11:35 PM	Brussels	Midi Bus Station	Economy	$65	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 2/8/2026 12:00:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 2/8/2026 11:35:00 PM. 50 Economy ticket for $65 per person are available. Travel duration is 11h 35m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
BlaBlaCar Bus	10h 15m	6:15 AM	Lyon	Perrache Train Station	4:30 PM	Brussels	Midi Bus Station	Economy	$22	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 2/9/2026 6:15:00 AM to Midi Bus Station, Brussels (Belgium) arriving at 2/9/2026 4:30:00 PM. 50 Economy ticket for $22 per person are available. Travel duration is 10h 15m
BlaBlaCar Bus	11h 35m	12:00 PM	Lyon	Perrache Train Station	11:35 PM	Brussels	Midi Bus Station	Economy	$25	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 2/9/2026 12:00:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 2/9/2026 11:35:00 PM. 50 Economy ticket for $25 per person are available. Travel duration is 11h 35m
BlaBlaCar Bus	10h 50m	2:40 AM	Lyon	Perrache Train Station	1:30 PM	Brussels	Midi Bus Station	Economy	$28	A Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 2/9/2026 2:40:00 AM to Midi Bus Station, Brussels (Belgium) arriving at 2/9/2026 1:30:00 PM. 50 Economy ticket for $28 per person are available. Travel duration is 10h 50m
FlixBus	14h 15m	2:25 AM	Lyon	Perrache Bus Stop	4:40 PM	Brussels	North Station	Economy	$37	A Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 2/9/2026 2:25:00 AM to North Station, Brussels (Belgium) arriving at 2/9/2026 4:40:00 PM. 50 Economy ticket for $37 per person are available. Travel duration is 14h 15m

Best Price Offer: The price for the cheapest bus from Lyon to Brussels is $22 on 2/5/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Lyon and Brussels

See here how frequent the connections between Lyon and Brussels are, during different times and days of the week.

Monday is the busiest day, with more than 7 daily buses from Lyon to Brussels. Tuesday has instead the fewest connections, with only 1 daily coaches between Lyon and Brussels.

The busiest time of the day is the Morning, with 10 buses from Lyon to Brussels, while Afternoon sees the fewest connections between Lyon and Brussels, with 4 offers.

Facts about the bus from Lyon to Brussels

Compare all providers like BlaBlaCar Bus and FlixBus that travel 4 times every day by bus from Lyon to Brussels in one click! Book your bus ticket from Lyon to Brussels starting from $22!

Cheapest Bus	$22
Fastest Bus	9h 40m
Earliest Bus	11:59 PM
Latest Bus	8:40 PM
Daily Bus Routes	4 Ø
Distance	352.7 miles
Bus Companies	BlaBlaCar Bus and FlixBus

Cheapest bus connections from Lyon to Brussels

Every day, 4 buses from 2 bus companies leave Lyon for Brussels: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 02/03/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 02/01

Monday 02/02

Tuesday 02/03

$52

Wednesday 02/04

$52

Thursday 02/05

$22

Friday 02/06

$26

Saturday 02/07

$30

Sunday 02/08

$24

Monday 02/09

$22

Tuesday 02/10

$22

Wednesday 02/11

$39

Thursday 02/12

$22

Friday 02/13

$27

Saturday 02/14

$31

Sunday 02/15

$45

Monday 02/16

$24

Tuesday 02/17

$26

Wednesday 02/18

$42

Thursday 02/19

$27

Friday 02/20

$32

Saturday 02/21

$37

Sunday 02/22

$46

Monday 02/23

$30

Tuesday 02/24

$25

Wednesday 02/25

$30

Thursday 02/26

$25

Friday 02/27

$30

Saturday 02/28

The cheapest time to travel from Lyon to Brussels

See here on which day and which time of the day you can find the cheapest bus ticket from Lyon to Brussels, for the next 30 days.

With a price starting from $22, Monday is the cheapest day for a bus from Lyon to Brussels. Saturday instead is the most expensive day with prices starting from $30.

Morning is the cheapest day time for bus tickets from Lyon to Brussels, with $22. Evening is the most expensive time of the day with prices starting from $32.

How to save money travelling from Lyon to Brussels

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Lyon to Brussels in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Lyon to Brussels, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Lyon to Brussels are also emptier.

Beloved bus companies from Lyon to Brussels

These are the most booked bus companies between Lyon to Brussels from our users.

FlixBus from Lyon to Brussels

Here you will find the key facts about the FlixBus bus route Lyon to Brussels:

Cheapest Price	$37
Fastest Bus	14h 15m
Earliest Bus	2:25 AM
Last Bus	2:25 AM
Daily Connections	1 Ø
Found on	1/13/2026

All bus stations and stops in Lyon and Brussels

In the map below, you can see where to find all bus stations in Lyon and Brussels.

Perrache Bus Stop

Cours de Verdun 14

Pont Kitchener R.G. Bus Stop

Cours de Verdun

Maison Carrée Bus Stop

Les Charrières 69570

Girondins - Yves Farge Bus Stop

Saint Paul Train Station

Midi Bus Station

Avenue Fonsny 1

North Station

Rue du Progrès 80

Congrès

Boulevard Pachéco 7

Central Station

City Tours

Rue du Marché Aux Herbes 82

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Lyon to Brussels? Compare all modes of transports from Lyon to Brussels.

Service and Comfort on the bus from Lyon to Brussels

Want to know which seat classes are available on the buses from Lyon to Brussels? Or which bus companies serve the route Lyon to Brussels? Below you will find answers to your questions.

FAQs about the Lyon to Brussels bus

How much does a Lyon Brussels bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $22 and takes 10h 50m to reach Brussels. Compare offers to save money!

How much could I save by comparing buses from Lyon to Brussels?

This route is offered by 2 companies with a range of ticket prices between $22 and $165. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Brussels.

On average, how many connections are available from Lyon to Brussels each day?

Every day, the Lyon to Brussels bus route is served by approximately 4 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Lyon to Brussels take?

The fastest bus from Lyon to Brussels is offered by BlaBlaCar Bus and takes 9h 40m. Bus tickets for this connection cost $65. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Lyon to Brussels?

The earliest bus arriving in Brussels from Lyon starts at 11:59 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Lyon to Brussels?

The latest bus trip departing from Lyon for Brussels starts at 8:40 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Lyon Brussels route?

When traveling by bus from Lyon to Brussels, passengers can travel with BlaBlaCar Bus and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Lyon and Brussels?

You can check all the direct connections between Lyon and Brussels by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: BlaBlaCar Bus and FlixBus.

What can I take with me on the Lyon to Brussels bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Lyon Brussels bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Lyon Brussels bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Lyon to Brussels on your planned travel date.

How does CheckMyBus find the best bus deals from Lyon to Brussels?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 4 daily trips between Lyon and Brussels. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Lyon to Brussels?

Prices and availability for 4 trips between Lyon and Brussels change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Lyon to Brussels

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Lyon and to Brussels

Here’s an overview of the most popular bus routes to Lyon and to Brussels. Simply click on the connection of your choice, and you will find all the details about your bus route!