Bus Prague to Lyon: Compare prices and save money

Compare all timetables for the bus from Prague to Lyon

Here is a selection of the cheapest bus trips from the schedule from Prague to Lyon from various bus operators like FlixBus, BlaBlaCar Bus or RegioJet for the next days.

today

from $70

tomorrow

from $91

Tuesday

from $83

Wednesday

from $83

Thursday

from $70

Friday

from $70

Saturday

from $70

Cheapest bus trips today

Prices are for one way and one person
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
BlaBlaCar Bus	16h 50m	1:35 PM	Prague	ÚAN Florenc	6:25 AM	Lyon	Perrache Train Station	Economy	$70	A Bus from BlaBlaCar Bus goes from ÚAN Florenc, Prague (Czech Republic) at 7/20/2025 1:35:00 PM to Perrache Train Station, Lyon (France) arriving at 7/21/2025 6:25:00 AM. 50 Economy ticket for $70 per person are available. Travel duration is 16h 50m
BlaBlaCar Bus	16h 50m	1:35 PM	Prague	ÚAN Florenc	6:25 AM	Lyon	Perrache Bus Stop	Economy	$70	A Bus from BlaBlaCar Bus goes from ÚAN Florenc, Prague (Czech Republic) at 7/20/2025 1:35:00 PM to Perrache Bus Stop, Lyon (France) arriving at 7/21/2025 6:25:00 AM. 50 Economy ticket for $70 per person are available. Travel duration is 16h 50m
FlixBus	19h 25m	3:50 AM	Prague	Wilsonova Bus Station	11:15 PM	Lyon	Perrache Bus Stop	Economy	$101	A Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 7/20/2025 3:50:00 AM to Perrache Bus Stop, Lyon (France) arriving at 7/20/2025 11:15:00 PM. 50 Economy ticket for $101 per person are available. Travel duration is 19h 25m
FlixBus	19h 5m	4:10 AM	Prague	Na Knížecí Station	11:15 PM	Lyon	Perrache Bus Stop	Economy	$101	A Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 7/20/2025 4:10:00 AM to Perrache Bus Stop, Lyon (France) arriving at 7/20/2025 11:15:00 PM. 50 Economy ticket for $101 per person are available. Travel duration is 19h 5m
FlixBus	16h 35m	6:40 AM	Prague	ÚAN Florenc	11:15 PM	Lyon	Perrache Bus Stop	Economy	$110	A Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 7/20/2025 6:40:00 AM to Perrache Bus Stop, Lyon (France) arriving at 7/20/2025 11:15:00 PM. 50 Economy ticket for $110 per person are available. Travel duration is 16h 35m

Cheapest bus trips tomorrow

Prices are for one way and one person
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	14h 35m	9:50 PM	Prague	Na Knížecí Station	12:25 PM	Lyon	Perrache Bus Stop	Economy	$91	A Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 7/21/2025 9:50:00 PM to Perrache Bus Stop, Lyon (France) arriving at 7/22/2025 12:25:00 PM. 50 Economy ticket for $91 per person are available. Travel duration is 14h 35m
FlixBus	15h 0m	9:25 PM	Prague	ÚAN Florenc	12:25 PM	Lyon	Perrache Bus Stop	Economy	$91	A Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 7/21/2025 9:25:00 PM to Perrache Bus Stop, Lyon (France) arriving at 7/22/2025 12:25:00 PM. 50 Economy ticket for $91 per person are available. Travel duration is 15h 0m
FlixBus	17h 20m	11:15 AM	Prague	Wilsonova Bus Station	4:35 AM	Lyon	Perrache Bus Stop	Economy	$94	A Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 7/21/2025 11:15:00 AM to Perrache Bus Stop, Lyon (France) arriving at 7/22/2025 4:35:00 AM. 50 Economy ticket for $94 per person are available. Travel duration is 17h 20m
FlixBus	16h 35m	6:40 AM	Prague	ÚAN Florenc	11:15 PM	Lyon	Perrache Bus Stop	Economy	$95	A Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 7/21/2025 6:40:00 AM to Perrache Bus Stop, Lyon (France) arriving at 7/21/2025 11:15:00 PM. 50 Economy ticket for $95 per person are available. Travel duration is 16h 35m
FlixBus	17h 10m	3:05 PM	Prague	Zličín	8:15 AM	Lyon	Perrache Bus Stop	Economy	$95	A Bus from FlixBus goes from Zličín, Prague (Czech Republic) at 7/21/2025 3:05:00 PM to Perrache Bus Stop, Lyon (France) arriving at 7/22/2025 8:15:00 AM. 50 Economy ticket for $95 per person are available. Travel duration is 17h 10m

Cheapest bus trips Tuesday

Prices are for one way and one person
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	14h 35m	9:50 PM	Prague	Na Knížecí Station	12:25 PM	Lyon	Perrache Bus Stop	Economy	$83	A Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 7/22/2025 9:50:00 PM to Perrache Bus Stop, Lyon (France) arriving at 7/23/2025 12:25:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 14h 35m
FlixBus	15h 0m	9:25 PM	Prague	ÚAN Florenc	12:25 PM	Lyon	Perrache Bus Stop	Economy	$83	A Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 7/22/2025 9:25:00 PM to Perrache Bus Stop, Lyon (France) arriving at 7/23/2025 12:25:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 15h 0m
FlixBus	16h 45m	4:15 PM	Prague	Wilsonova Bus Station	9:00 AM	Lyon	Perrache Bus Stop	Economy	$86	A Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 7/22/2025 4:15:00 PM to Perrache Bus Stop, Lyon (France) arriving at 7/23/2025 9:00:00 AM. 50 Economy ticket for $86 per person are available. Travel duration is 16h 45m
FlixBus	17h 0m	4:00 PM	Prague	ÚAN Florenc	9:00 AM	Lyon	Perrache Bus Stop	Economy	$86	A Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 7/22/2025 4:00:00 PM to Perrache Bus Stop, Lyon (France) arriving at 7/23/2025 9:00:00 AM. 50 Economy ticket for $86 per person are available. Travel duration is 17h 0m
FlixBus	16h 35m	6:40 AM	Prague	ÚAN Florenc	11:15 PM	Lyon	Perrache Bus Stop	Economy	$91	A Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 7/22/2025 6:40:00 AM to Perrache Bus Stop, Lyon (France) arriving at 7/22/2025 11:15:00 PM. 50 Economy ticket for $91 per person are available. Travel duration is 16h 35m

Cheapest bus trips Wednesday

Prices are for one way and one person
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	19h 10m	1:05 PM	Prague	Wilsonova Bus Station	8:15 AM	Lyon	Perrache Bus Stop	Economy	$83	A Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 7/23/2025 1:05:00 PM to Perrache Bus Stop, Lyon (France) arriving at 7/24/2025 8:15:00 AM. 50 Economy ticket for $83 per person are available. Travel duration is 19h 10m
FlixBus	16h 35m	6:40 AM	Prague	ÚAN Florenc	11:15 PM	Lyon	Perrache Bus Stop	Economy	$83	A Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 7/23/2025 6:40:00 AM to Perrache Bus Stop, Lyon (France) arriving at 7/23/2025 11:15:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 16h 35m
FlixBus	19h 25m	3:50 AM	Prague	Wilsonova Bus Station	11:15 PM	Lyon	Perrache Bus Stop	Economy	$84	A Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 7/23/2025 3:50:00 AM to Perrache Bus Stop, Lyon (France) arriving at 7/23/2025 11:15:00 PM. 50 Economy ticket for $84 per person are available. Travel duration is 19h 25m
FlixBus	19h 5m	4:10 AM	Prague	Na Knížecí Station	11:15 PM	Lyon	Perrache Bus Stop	Economy	$84	A Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 7/23/2025 4:10:00 AM to Perrache Bus Stop, Lyon (France) arriving at 7/23/2025 11:15:00 PM. 50 Economy ticket for $84 per person are available. Travel duration is 19h 5m
FlixBus	16h 45m	4:15 PM	Prague	Wilsonova Bus Station	9:00 AM	Lyon	Perrache Bus Stop	Economy	$86	A Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 7/23/2025 4:15:00 PM to Perrache Bus Stop, Lyon (France) arriving at 7/24/2025 9:00:00 AM. 50 Economy ticket for $86 per person are available. Travel duration is 16h 45m

Cheapest bus trips Thursday

Prices are for one way and one person
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
BlaBlaCar Bus	16h 50m	1:35 PM	Prague	ÚAN Florenc	6:25 AM	Lyon	Perrache Train Station	Economy	$70	A Bus from BlaBlaCar Bus goes from ÚAN Florenc, Prague (Czech Republic) at 7/24/2025 1:35:00 PM to Perrache Train Station, Lyon (France) arriving at 7/25/2025 6:25:00 AM. 50 Economy ticket for $70 per person are available. Travel duration is 16h 50m
BlaBlaCar Bus	16h 50m	1:35 PM	Prague	ÚAN Florenc	6:25 AM	Lyon	Perrache Bus Stop	Economy	$70	A Bus from BlaBlaCar Bus goes from ÚAN Florenc, Prague (Czech Republic) at 7/24/2025 1:35:00 PM to Perrache Bus Stop, Lyon (France) arriving at 7/25/2025 6:25:00 AM. 50 Economy ticket for $70 per person are available. Travel duration is 16h 50m
RegioJet	15h 50m	11:00 PM	Prague	ÚAN Florenc	2:50 PM	Lyon	Perrache Bus Stop	Economy	$81	A Bus from RegioJet goes from ÚAN Florenc, Prague (Czech Republic) at 7/24/2025 11:00:00 PM to Perrache Bus Stop, Lyon (France) arriving at 7/25/2025 2:50:00 PM. 50 Economy ticket for $81 per person are available. Travel duration is 15h 50m
FlixBus	16h 45m	4:15 PM	Prague	Wilsonova Bus Station	9:00 AM	Lyon	Perrache Bus Stop	Economy	$86	A Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 7/24/2025 4:15:00 PM to Perrache Bus Stop, Lyon (France) arriving at 7/25/2025 9:00:00 AM. 50 Economy ticket for $86 per person are available. Travel duration is 16h 45m
FlixBus	17h 0m	4:00 PM	Prague	ÚAN Florenc	9:00 AM	Lyon	Perrache Bus Stop	Economy	$86	A Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 7/24/2025 4:00:00 PM to Perrache Bus Stop, Lyon (France) arriving at 7/25/2025 9:00:00 AM. 50 Economy ticket for $86 per person are available. Travel duration is 17h 0m

Cheapest bus trips Friday

Prices are for one way and one person
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
BlaBlaCar Bus	16h 45m	1:35 PM	Prague	ÚAN Florenc	6:20 AM	Lyon	Perrache Train Station	Economy	$70	A Bus from BlaBlaCar Bus goes from ÚAN Florenc, Prague (Czech Republic) at 7/25/2025 1:35:00 PM to Perrache Train Station, Lyon (France) arriving at 7/26/2025 6:20:00 AM. 50 Economy ticket for $70 per person are available. Travel duration is 16h 45m
BlaBlaCar Bus	16h 45m	1:35 PM	Prague	ÚAN Florenc	6:20 AM	Lyon	Perrache Bus Stop	Economy	$70	A Bus from BlaBlaCar Bus goes from ÚAN Florenc, Prague (Czech Republic) at 7/25/2025 1:35:00 PM to Perrache Bus Stop, Lyon (France) arriving at 7/26/2025 6:20:00 AM. 50 Economy ticket for $70 per person are available. Travel duration is 16h 45m
FlixBus	19h 25m	3:50 AM	Prague	Wilsonova Bus Station	11:15 PM	Lyon	Perrache Bus Stop	Economy	$95	A Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 7/25/2025 3:50:00 AM to Perrache Bus Stop, Lyon (France) arriving at 7/25/2025 11:15:00 PM. 50 Economy ticket for $95 per person are available. Travel duration is 19h 25m
FlixBus	19h 5m	4:10 AM	Prague	Na Knížecí Station	11:15 PM	Lyon	Perrache Bus Stop	Economy	$95	A Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 7/25/2025 4:10:00 AM to Perrache Bus Stop, Lyon (France) arriving at 7/25/2025 11:15:00 PM. 50 Economy ticket for $95 per person are available. Travel duration is 19h 5m
BlaBlaCar Bus	20h 45m	8:20 AM	Prague	ÚAN Florenc	5:05 AM	Lyon	Perrache Train Station	Economy	$100	A Bus from BlaBlaCar Bus goes from ÚAN Florenc, Prague (Czech Republic) at 7/25/2025 8:20:00 AM to Perrache Train Station, Lyon (France) arriving at 7/26/2025 5:05:00 AM. 50 Economy ticket for $100 per person are available. Travel duration is 20h 45m

Cheapest bus trips Saturday

Prices are for one way and one person
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
BlaBlaCar Bus	16h 50m	1:35 PM	Prague	ÚAN Florenc	6:25 AM	Lyon	Perrache Train Station	Economy	$70	A Bus from BlaBlaCar Bus goes from ÚAN Florenc, Prague (Czech Republic) at 7/26/2025 1:35:00 PM to Perrache Train Station, Lyon (France) arriving at 7/27/2025 6:25:00 AM. 50 Economy ticket for $70 per person are available. Travel duration is 16h 50m
BlaBlaCar Bus	16h 50m	1:35 PM	Prague	ÚAN Florenc	6:25 AM	Lyon	Perrache Bus Stop	Economy	$70	A Bus from BlaBlaCar Bus goes from ÚAN Florenc, Prague (Czech Republic) at 7/26/2025 1:35:00 PM to Perrache Bus Stop, Lyon (France) arriving at 7/27/2025 6:25:00 AM. 50 Economy ticket for $70 per person are available. Travel duration is 16h 50m
BlaBlaCar Bus	20h 50m	7:00 PM	Prague	ÚAN Florenc	3:50 PM	Lyon	Perrache Train Station	Economy	$77	A Bus from BlaBlaCar Bus goes from ÚAN Florenc, Prague (Czech Republic) at 7/26/2025 7:00:00 PM to Perrache Train Station, Lyon (France) arriving at 7/27/2025 3:50:00 PM. 50 Economy ticket for $77 per person are available. Travel duration is 20h 50m
FlixBus	17h 10m	3:05 PM	Prague	Zličín	8:15 AM	Lyon	Perrache Bus Stop	Economy	$81	A Bus from FlixBus goes from Zličín, Prague (Czech Republic) at 7/26/2025 3:05:00 PM to Perrache Bus Stop, Lyon (France) arriving at 7/27/2025 8:15:00 AM. 50 Economy ticket for $81 per person are available. Travel duration is 17h 10m
FlixBus	19h 25m	3:50 AM	Prague	Wilsonova Bus Station	11:15 PM	Lyon	Perrache Bus Stop	Economy	$84	A Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 7/26/2025 3:50:00 AM to Perrache Bus Stop, Lyon (France) arriving at 7/26/2025 11:15:00 PM. 50 Economy ticket for $84 per person are available. Travel duration is 19h 25m

Frequency of bus connections between Prague and Lyon

See here how frequent the connections between Prague and Lyon are, during different times and days of the week.

Thursday is the busiest day, with more than 18 daily buses from Prague to Lyon. Monday has instead the fewest connections, with only 13 daily coaches between Prague and Lyon.

The busiest time of the day is the Afternoon, with 50 buses from Prague to Lyon, while Night sees the fewest connections between Prague and Lyon, with 14 offers.

Facts about the bus from Prague to Lyon

Compare all providers like FlixBus, BlaBlaCar Bus and RegioJet that travel 15 times every day by bus from Prague to Lyon in one click! Book your bus ticket from Prague to Lyon starting from $70!

Cheapest Bus	$70
Fastest Bus	14h 35m
Earliest Bus	3:50 AM
Latest Bus	9:50 PM
Daily Bus Routes	15 Ø
Distance	535.0 miles
Bus Companies	FlixBus, BlaBlaCar Bus and RegioJet

Cheapest bus connections from Prague to Lyon

Every day, 15 buses from 3 bus companies leave Prague for Lyon: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/21/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 07/20

$70

Monday 07/21

$91

Tuesday 07/22

$83

Wednesday 07/23

$83

Thursday 07/24

$70

Friday 07/25

$95

Saturday 07/26

$70

Sunday 07/27

$97

Monday 07/28

$84

Tuesday 07/29

$79

Wednesday 07/30

$74

Thursday 07/31

$70

Friday 08/01

$99

Saturday 08/02

$70

Sunday 08/03

$77

Monday 08/04

$76

Tuesday 08/05

$71

Wednesday 08/06

$73

Thursday 08/07

$70

Friday 08/08

$91

Saturday 08/09

$81

Sunday 08/10

$90

Monday 08/11

$79

Tuesday 08/12

$73

Wednesday 08/13

$69

Thursday 08/14

$70

Friday 08/15

$73

Saturday 08/16

The cheapest time to travel from Prague to Lyon

See here on which day and which time of the day you can find the cheapest bus ticket from Prague to Lyon, for the next 30 days.

With a price starting from $70, Sunday is the cheapest day for a bus from Prague to Lyon. Monday instead is the most expensive day with prices starting from $91.

Afternoon is the cheapest day time for bus tickets from Prague to Lyon, with $70. Night is the most expensive time of the day with prices starting from $84.

How to save money travelling from Prague to Lyon

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Prague to Lyon in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Prague to Lyon, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Prague to Lyon are also emptier.

All bus stations and stops in Prague and Lyon

In the map below, you can see where to find all bus stations in Prague and Lyon.

Na Knížecí Station

Za Ženskými domovy / Ostrovského

ÚAN Florenc

Křižíkova 279

Wilsonova Bus Station

Wilsonova 300/8

Hradčanská

Milady Horákové 115/107

Train station Wilsonova

Wilsonova 300/8

Perrache Bus Stop

Cours de Verdun 14

Saint Paul Train Station

Pont Kitchener R.G. Bus Stop

Cours de Verdun

Maison Carrée Bus Stop

Les Charrières 69570

Girondins - Yves Farge Bus Stop

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Prague to Lyon? Compare all modes of transports from Prague to Lyon.

Service and Comfort on the bus from Prague to Lyon

Want to know which seat classes are available on the buses from Prague to Lyon? Or which bus companies serve the route Prague to Lyon? Below you will find answers to your questions.

FAQs about the Prague to Lyon bus

How much does a Prague Lyon bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $70 and takes 16h 50m to reach Lyon. Compare offers to save money!

How much could I save by comparing buses from Prague to Lyon?

This route is offered by 3 companies with a range of ticket prices between $70 and $175. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Lyon.

On average, how many connections are available from Prague to Lyon each day?

Every day, the Prague to Lyon bus route is served by approximately 15 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Prague to Lyon take?

The fastest bus from Prague to Lyon is offered by FlixBus and takes 14h 35m. Bus tickets for this connection cost $117. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Prague to Lyon?

The earliest bus arriving in Lyon from Prague starts at 3:50 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Prague to Lyon?

The latest bus trip departing from Prague for Lyon starts at 9:50 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Prague Lyon route?

When traveling by bus from Prague to Lyon, passengers can travel with FlixBus, BlaBlaCar Bus and RegioJet. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Prague and Lyon?

You can check all the direct connections between Prague and Lyon by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus, BlaBlaCar Bus and RegioJet.

What can I take with me on the Prague to Lyon bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Prague Lyon bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Prague Lyon bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Prague to Lyon on your planned travel date.

Available seat classes which are offered on the bus route Prague to Lyon

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Prague and to Lyon

Here’s an overview of the most popular bus routes to Prague and to Lyon. Simply click on the connection of your choice, and you will find all the details about your bus route!