Bus from Prague to Lyon from $56

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Compare all timetables for the bus from Prague to Lyon

Here is a selection of the cheapest bus trips from the schedule from Prague to Lyon from various bus operators like FlixBus or RegioJet for the next days.

today
$79
tomorrow
$69
Tuesday
$73
Wednesday
$77
Thursday
$94
Friday
$99
Saturday
$101

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 15h 0m 9:25 PM Prague ÚAN Florenc 12:25 PM Lyon Perrache Bus Stop  Economy $79
FlixBus 14h 35m 9:50 PM Prague Na Knížecí Station 12:25 PM Lyon Perrache Bus Stop  Economy $79
FlixBus 19h 20m 12:55 PM Prague Zličín 8:15 AM Lyon Perrache Bus Stop  Economy $83
FlixBus 17h 0m 4:00 PM Prague ÚAN Florenc 9:00 AM Lyon Perrache Bus Stop  Economy $95
FlixBus 16h 45m 4:15 PM Prague Wilsonova Bus Station 9:00 AM Lyon Perrache Bus Stop  Economy $95

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 14h 35m 9:50 PM Prague Na Knížecí Station 12:25 PM Lyon Perrache Bus Stop  Economy $69
FlixBus 15h 0m 9:25 PM Prague ÚAN Florenc 12:25 PM Lyon Perrache Bus Stop  Economy $69
FlixBus 17h 20m 11:15 AM Prague Wilsonova Bus Station 4:35 AM Lyon Perrache Bus Stop  Economy $73
FlixBus 17h 10m 3:05 PM Prague Zličín 8:15 AM Lyon Perrache Bus Stop  Economy $74
FlixBus 17h 5m 3:10 PM Prague ÚAN Florenc 8:15 AM Lyon Perrache Bus Stop  Economy $79

Cheapest bus trips Tuesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 19h 35m 9:10 AM Prague Na Knížecí Station 4:45 AM Lyon Perrache Bus Stop  Economy $73
FlixBus 22h 20m 10:15 PM Prague Na Knížecí Station 8:35 PM Lyon Perrache Bus Stop  Economy $73
FlixBus 19h 25m 3:50 AM Prague Wilsonova Bus Station 11:15 PM Lyon Perrache Bus Stop  Economy $74
FlixBus 22h 55m 5:50 AM Prague Wilsonova Bus Station 4:45 AM Lyon Perrache Bus Stop  Economy $74
FlixBus 19h 5m 4:10 AM Prague Na Knížecí Station 11:15 PM Lyon Perrache Bus Stop  Economy $74

Cheapest bus trips Wednesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 19h 35m 9:10 AM Prague Na Knížecí Station 4:45 AM Lyon Perrache Bus Stop  Economy $77
FlixBus 14h 35m 9:50 PM Prague Na Knížecí Station 12:25 PM Lyon Perrache Bus Stop  Economy $77
FlixBus 15h 0m 9:25 PM Prague ÚAN Florenc 12:25 PM Lyon Perrache Bus Stop  Economy $77
FlixBus 17h 10m 3:05 PM Prague Zličín 8:15 AM Lyon Perrache Bus Stop  Economy $78
FlixBus 19h 25m 3:50 AM Prague Wilsonova Bus Station 11:15 PM Lyon Perrache Bus Stop  Economy $80

Cheapest bus trips Thursday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
RegioJet 15h 50m 11:00 PM Prague ÚAN Florenc 2:50 PM Lyon Perrache Bus Stop  Economy $94
FlixBus 16h 45m 4:15 PM Prague Wilsonova Bus Station 9:00 AM Lyon Perrache Bus Stop  Economy $95
FlixBus 17h 0m 4:00 PM Prague ÚAN Florenc 9:00 AM Lyon Perrache Bus Stop  Economy $95
FlixBus 14h 35m 9:50 PM Prague Na Knížecí Station 12:25 PM Lyon Perrache Bus Stop  Economy $102
  • Did you know that if you travel from Prague to Lyon via Bern, you can save more than $14? You can find the corresponding connections below.
    • FlixBus
      17h 55m
      0
      7:30 PM
      Prague
      ÚAN Florenc
      6:25 AM
      Bern
      Bern Car Terminal Neufeld
      0
      FlixBus
      Economy
      $52
      • Waiting Time 1h 30m
    • FlixBus
      5h 30m
      0
      7:55 AM
      Bern
      Bern Car Terminal Neufeld
      1:25 PM
      Lyon
      Perrache Bus Stop
      0
      FlixBus
      Economy
      $28
    Travel time is 3h 20m longer, but you will save $14

Cheapest bus trips Friday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 19h 25m 3:50 AM Prague Wilsonova Bus Station 11:15 PM Lyon Perrache Bus Stop  Economy $99
FlixBus 19h 5m 4:10 AM Prague Na Knížecí Station 11:15 PM Lyon Perrache Bus Stop  Economy $99
FlixBus 14h 35m 9:50 PM Prague Na Knížecí Station 12:25 PM Lyon Perrache Bus Stop  Economy $107
FlixBus 15h 0m 9:25 PM Prague ÚAN Florenc 12:25 PM Lyon Perrache Bus Stop  Economy $107
FlixBus 16h 45m 4:15 PM Prague Wilsonova Bus Station 9:00 AM Lyon Perrache Bus Stop  Economy $114
  • Did you know that if you travel from Prague to Lyon via Bern, you can save more than $19? You can find the corresponding connections below.
    • FlixBus
      17h 55m
      0
      7:30 PM
      Prague
      ÚAN Florenc
      6:25 AM
      Bern
      Bern Car Terminal Neufeld
      0
      FlixBus
      Economy
      $52
      • Waiting Time 1h 30m
    • FlixBus
      5h 30m
      0
      7:55 AM
      Bern
      Bern Car Terminal Neufeld
      1:25 PM
      Lyon
      Perrache Bus Stop
      0
      FlixBus
      Economy
      $28
    Travel time is 3h 20m longer, but you will save $19

Cheapest bus trips Saturday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 14h 35m 9:50 PM Prague Na Knížecí Station 12:25 PM Lyon Perrache Bus Stop  Economy $101
FlixBus 15h 0m 9:25 PM Prague ÚAN Florenc 12:25 PM Lyon Perrache Bus Stop  Economy $101
FlixBus 16h 45m 4:15 PM Prague Wilsonova Bus Station 9:00 AM Lyon Perrache Bus Stop  Economy $111
FlixBus 17h 0m 4:00 PM Prague ÚAN Florenc 9:00 AM Lyon Perrache Bus Stop  Economy $111
FlixBus 17h 20m 11:15 AM Prague Wilsonova Bus Station 4:35 AM Lyon Perrache Bus Stop  Economy $117
  • Did you know that if you travel from Prague to Lyon via Bern, you can save more than $21? You can find the corresponding connections below.
    • FlixBus
      17h 55m
      0
      7:30 PM
      Prague
      ÚAN Florenc
      6:25 AM
      Bern
      Bern Car Terminal Neufeld
      0
      FlixBus
      Economy
      $52
      • Waiting Time 1h 30m
    • FlixBus
      5h 30m
      0
      7:55 AM
      Bern
      Bern Car Terminal Neufeld
      1:25 PM
      Lyon
      Perrache Bus Stop
      0
      FlixBus
      Economy
      $28
    Travel time is 3h 20m longer, but you will save $21

Best Price Offer: The price for the cheapest bus from Prague to Lyon is $56 on 1/7/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Prague and Lyon

See here how frequent the connections between Prague and Lyon are, during different times and days of the week.
Tuesday is the busiest day, with more than 17 daily buses from Prague to Lyon. Sunday has instead the fewest connections, with only 11 daily coaches between Prague and Lyon.
The busiest time of the day is the Afternoon, with 44 buses from Prague to Lyon, while Night sees the fewest connections between Prague and Lyon, with 13 offers.

Facts about the bus from Prague to Lyon

Compare all providers like FlixBus and RegioJet that travel 13 times every day by bus from Prague to Lyon in one click! Book your bus ticket from Prague to Lyon starting from $56!

Cheapest Bus $56
Fastest Bus 14h 35m
Earliest Bus 6:40 AM
Latest Bus 9:50 PM
Daily Bus Routes 13 Ø
Distance 535.0 miles
Bus Companies FlixBus and RegioJet

Cheapest bus connections from Prague to Lyon

Every day, 13 buses from 2 bus companies leave Prague for Lyon: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/14/2025 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 12/14
$79
Monday 12/15
$69
Tuesday 12/16
$73
Wednesday 12/17
$77
Thursday 12/18
$95
Friday 12/19
$99
Saturday 12/20
$101
Sunday 12/21
$103
Monday 12/22
$101
Tuesday 12/23
$110
Wednesday 12/24
$98
Thursday 12/25
$95
Friday 12/26
$105
Saturday 12/27
$111
Sunday 12/28
$103
Monday 12/29
$105
Tuesday 12/30
$102
Wednesday 12/31
$87
Thursday 01/01
$98
Friday 01/02
$116
Saturday 01/03
$96
Sunday 01/04
$92
Monday 01/05
$70
Tuesday 01/06
$65
Wednesday 01/07
$56
Thursday 01/08
$56
Friday 01/09
$57
Saturday 01/10

The cheapest time to travel from Prague to Lyon

See here on which day and which time of the day you can find the cheapest bus ticket from Prague to Lyon, for the next 30 days.
With a price starting from $56, Wednesday is the cheapest day for a bus from Prague to Lyon. Saturday instead is the most expensive day with prices starting from $96.
Night is the cheapest day time for bus tickets from Prague to Lyon, with $56. Afternoon is the most expensive time of the day with prices starting from $74.

How to save money travelling from Prague to Lyon

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Prague to Lyon in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Prague to Lyon, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Prague to Lyon are also emptier.

Beloved bus companies from Prague to Lyon

These are the most booked bus companies between Prague to Lyon from our users.

FlixBus from Prague to Lyon

FlixBus

Here you will find the key facts about the FlixBus bus route Prague to Lyon:

Cheapest Price $69
Fastest Bus 14h 35m
Earliest Bus 6:40 AM
Last Bus 9:50 PM
Daily Connections 13 Ø
Found on 12/14/2025

All bus stations and stops in Prague and Lyon

In the map below, you can see where to find all bus stations in Prague and Lyon.

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Prague to Lyon? Compare all modes of transports from Prague to Lyon.

Service and Comfort on the bus from Prague to Lyon

Want to know which seat classes are available on the buses from Prague to Lyon? Or which bus companies serve the route Prague to Lyon? Below you will find answers to your questions.

FAQs about the Prague to Lyon bus

How much does a Prague Lyon bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $56 and takes 14h 35m to reach Lyon. Compare offers to save money!

How much could I save by comparing buses from Prague to Lyon?

This route is offered by 2 companies with a range of ticket prices between $56 and $162. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Lyon.

On average, how many connections are available from Prague to Lyon each day?

Every day, the Prague to Lyon bus route is served by approximately 13 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Prague to Lyon take?

The fastest bus from Prague to Lyon is offered by FlixBus and takes 14h 35m. Bus tickets for this connection cost $79. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Prague to Lyon?

The earliest bus arriving in Lyon from Prague starts at 6:40 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Prague to Lyon?

The latest bus trip departing from Prague for Lyon starts at 9:50 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Prague Lyon route?

When traveling by bus from Prague to Lyon, passengers can travel with FlixBus and RegioJet. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Prague and Lyon?

You can check all the direct connections between Prague and Lyon by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and RegioJet.

What can I take with me on the Prague to Lyon bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Prague Lyon bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Prague Lyon bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Prague to Lyon on your planned travel date.

Available seat classes which are offered on the bus route Prague to Lyon

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Prague and to Lyon

Here’s an overview of the most popular bus routes to Prague and to Lyon. Simply click on the connection of your choice, and you will find all the details about your bus route!
Karlovy Vary to Prague bus Karlovy Vary to Prague bus
Copenhagen to Prague bus Copenhagen to Prague bus
Bus from Cologne to Prague Bus from Cologne to Prague
Bus from Minsk to Prague Bus from Minsk to Prague
Bus to Lyon from Manchester Bus to Lyon from Manchester
Buses Poitiers - Lyon Buses Poitiers - Lyon
Bus Berlin to Lyon Bus Berlin to Lyon
From Rennes to Lyon bus From Rennes to Lyon bus
Popular Airport Shuttles to Prague and to Lyon
CheckMyBus › Buses in Czech Republic › Bus to Prague › Bus to Lyon

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