Bus from Prague to Lyon from $54

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Compare all timetables for the bus from Prague to Lyon

Here is a selection of the cheapest bus trips from the schedule from Prague to Lyon from various bus operators like FlixBus, BlaBlaCar Bus or RegioJet for the next days.
today
from $79
tomorrow
from $61
Sunday
from $61
Monday
from $62
Tuesday
from $59
Wednesday
from $54
Thursday
from $57

Cheapest bus trips today

Prices are for one way and one person
  • FlixBus
    16h 45m
    0
    4:15 PM
    Prague
    Wilsonova Bus Station
    9:00 AM
    Lyon
    Perrache Bus Stop
    0
    FlixBus
    Economy
    $79
  • FlixBus
    17h 5m
    0
    3:10 PM
    Prague
    ÚAN Florenc
    8:15 AM
    Lyon
    Perrache Bus Stop
    0
    FlixBus
    Economy
    $79
  • FlixBus
    17h 0m
    0
    4:00 PM
    Prague
    ÚAN Florenc
    9:00 AM
    Lyon
    Perrache Bus Stop
    0
    FlixBus
    Economy
    $79
  • FlixBus
    17h 45m
    0
    2:30 PM
    Prague
    Černý Most
    8:15 AM
    Lyon
    Perrache Bus Stop
    0
    FlixBus
    Economy
    $79
  • FlixBus
    19h 25m
    0
    3:50 AM
    Prague
    Wilsonova Bus Station
    11:15 PM
    Lyon
    Perrache Bus Stop
    0
    FlixBus
    Economy
    $81

Cheapest bus trips tomorrow

Prices are for one way and one person
  • BlaBlaCar Bus
    16h 45m
    0
    1:35 PM
    Prague
    ÚAN Florenc
    6:20 AM
    Lyon
    Perrache Bus Stop
    0
    BlaBlaCar Bus
    Economy
    $61
  • BlaBlaCar Bus
    16h 45m
    0
    1:35 PM
    Prague
    ÚAN Florenc
    6:20 AM
    Lyon
    Perrache Train Station
    0
    BlaBlaCar Bus
    Economy
    $61
  • FlixBus
    17h 20m
    0
    11:15 AM
    Prague
    Wilsonova Bus Station
    4:35 AM
    Lyon
    Perrache Bus Stop
    0
    FlixBus
    Economy
    $75
  • FlixBus
    19h 25m
    0
    3:50 AM
    Prague
    Wilsonova Bus Station
    11:15 PM
    Lyon
    Perrache Bus Stop
    0
    FlixBus
    Economy
    $76
  • FlixBus
    19h 5m
    0
    4:10 AM
    Prague
    Na Knížecí Station
    11:15 PM
    Lyon
    Perrache Bus Stop
    0
    FlixBus
    Economy
    $76

Cheapest bus trips Sunday

Prices are for one way and one person
  • BlaBlaCar Bus
    16h 45m
    0
    1:35 PM
    Prague
    ÚAN Florenc
    6:20 AM
    Lyon
    Perrache Train Station
    0
    BlaBlaCar Bus
    Economy
    $61
  • BlaBlaCar Bus
    16h 45m
    0
    1:35 PM
    Prague
    ÚAN Florenc
    6:20 AM
    Lyon
    Perrache Bus Stop
    0
    BlaBlaCar Bus
    Economy
    $61
  • FlixBus
    14h 35m
    0
    9:50 PM
    Prague
    Na Knížecí Station
    12:25 PM
    Lyon
    Perrache Bus Stop
    0
    FlixBus
    Economy
    $82
  • FlixBus
    15h 0m
    0
    9:25 PM
    Prague
    ÚAN Florenc
    12:25 PM
    Lyon
    Perrache Bus Stop
    0
    FlixBus
    Economy
    $82
  • FlixBus
    16h 45m
    0
    4:15 PM
    Prague
    Wilsonova Bus Station
    9:00 AM
    Lyon
    Perrache Bus Stop
    0
    FlixBus
    Economy
    $105

Cheapest bus trips Monday

Prices are for one way and one person
  • FlixBus
    16h 45m
    0
    4:15 PM
    Prague
    Wilsonova Bus Station
    9:00 AM
    Lyon
    Perrache Bus Stop
    0
    FlixBus
    Economy
    $62
  • FlixBus
    17h 0m
    0
    4:00 PM
    Prague
    ÚAN Florenc
    9:00 AM
    Lyon
    Perrache Bus Stop
    0
    FlixBus
    Economy
    $62
  • FlixBus
    17h 5m
    0
    3:10 PM
    Prague
    ÚAN Florenc
    8:15 AM
    Lyon
    Perrache Bus Stop
    0
    FlixBus
    Economy
    $65
  • FlixBus
    17h 45m
    0
    2:30 PM
    Prague
    Černý Most
    8:15 AM
    Lyon
    Perrache Bus Stop
    0
    FlixBus
    Economy
    $65
  • FlixBus
    16h 35m
    0
    6:40 AM
    Prague
    ÚAN Florenc
    11:15 PM
    Lyon
    Perrache Bus Stop
    0
    FlixBus
    Economy
    $67

Cheapest bus trips Tuesday

Prices are for one way and one person
  • FlixBus
    17h 10m
    0
    3:05 PM
    Prague
    Zličín
    8:15 AM
    Lyon
    Perrache Bus Stop
    0
    FlixBus
    Economy
    $59
  • FlixBus
    19h 35m
    0
    9:00 AM
    Prague
    Wilsonova Bus Station
    4:35 AM
    Lyon
    Perrache Bus Stop
    0
    FlixBus
    Economy
    $61
  • FlixBus
    19h 10m
    0
    1:05 PM
    Prague
    Wilsonova Bus Station
    8:15 AM
    Lyon
    Perrache Bus Stop
    0
    FlixBus
    Economy
    $61
  • FlixBus
    16h 45m
    0
    4:15 PM
    Prague
    Wilsonova Bus Station
    9:00 AM
    Lyon
    Perrache Bus Stop
    0
    FlixBus
    Economy
    $65
  • FlixBus
    14h 35m
    0
    9:50 PM
    Prague
    Na Knížecí Station
    12:25 PM
    Lyon
    Perrache Bus Stop
    0
    FlixBus
    Economy
    $65

Cheapest bus trips Wednesday

Prices are for one way and one person
  • FlixBus
    19h 35m
    0
    9:00 AM
    Prague
    Wilsonova Bus Station
    4:35 AM
    Lyon
    Perrache Bus Stop
    0
    FlixBus
    Economy
    $54
  • FlixBus
    19h 25m
    0
    3:50 AM
    Prague
    Wilsonova Bus Station
    11:15 PM
    Lyon
    Perrache Bus Stop
    0
    FlixBus
    Economy
    $55
  • FlixBus
    19h 5m
    0
    4:10 AM
    Prague
    Na Knížecí Station
    11:15 PM
    Lyon
    Perrache Bus Stop
    0
    FlixBus
    Economy
    $55
  • BlaBlaCar Bus
    16h 20m
    0
    2:00 PM
    Prague
    ÚAN Florenc
    6:20 AM
    Lyon
    Perrache Train Station
    0
    BlaBlaCar Bus
    Economy
    $61

Cheapest bus trips Thursday

Prices are for one way and one person
  • RegioJet
    15h 50m
    0
    11:00 PM
    Prague
    ÚAN Florenc
    2:50 PM
    Lyon
    Perrache Bus Stop
    0
    RegioJet
    Economy
    $57
  • FlixBus
    17h 20m
    0
    11:15 AM
    Prague
    Wilsonova Bus Station
    4:35 AM
    Lyon
    Perrache Bus Stop
    0
    FlixBus
    Economy
    $59
  • FlixBus
    17h 10m
    0
    3:05 PM
    Prague
    Zličín
    8:15 AM
    Lyon
    Perrache Bus Stop
    0
    FlixBus
    Economy
    $59
  • BlaBlaCar Bus
    16h 45m
    0
    1:35 PM
    Prague
    ÚAN Florenc
    6:20 AM
    Lyon
    Perrache Train Station
    0
    BlaBlaCar Bus
    Economy
    $61
  • BlaBlaCar Bus
    16h 45m
    0
    1:35 PM
    Prague
    ÚAN Florenc
    6:20 AM
    Lyon
    Perrache Bus Stop
    0
    BlaBlaCar Bus
    Economy
    $61

Frequency of bus connections between Prague and Lyon

See here how frequent the connections between Prague and Lyon are, during different times and days of the week.
Thursday is the busiest day, with more than 18 daily buses from Prague to Lyon. Monday has instead the fewest connections, with only 13 daily coaches between Prague and Lyon.
The busiest time of the day is the Afternoon, with 49 buses from Prague to Lyon, while Night sees the fewest connections between Prague and Lyon, with 14 offers.

Facts about the bus from Prague to Lyon

Compare all providers like FlixBus, BlaBlaCar Bus and RegioJet that travel 15 times every day by bus from Prague to Lyon in one click! Book your bus ticket from Prague to Lyon starting from $54!

Cheapest Bus $54
Fastest Bus 14h 35m
Earliest Bus 3:50 AM
Latest Bus 11:00 PM
Daily Bus Routes 15 Ø
Distance 535.0 miles
Bus Companies FlixBus, BlaBlaCar Bus and RegioJet

Cheapest bus connections from Prague to Lyon

Every day, 15 buses from 3 bus companies leave Prague for Lyon: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 06/20/2025 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 06/15
Monday 06/16
Tuesday 06/17
Wednesday 06/18
Thursday 06/19
Friday 06/20
$79
Saturday 06/21
$61
Sunday 06/22
$61
Monday 06/23
$62
Tuesday 06/24
$59
Wednesday 06/25
$54
Thursday 06/26
$59
Friday 06/27
$76
Saturday 06/28
$61
Sunday 06/29
$82
Monday 06/30
$64
Tuesday 07/01
$61
Wednesday 07/02
$67
Thursday 07/03
$77
Friday 07/04
$69
Saturday 07/05
$69
Sunday 07/06
$86
Monday 07/07
$69
Tuesday 07/08
$68
Wednesday 07/09
$66
Thursday 07/10
$69
Friday 07/11
$72
Saturday 07/12

The cheapest time to travel from Prague to Lyon

See here on which day and which time of the day you can find the cheapest bus ticket from Prague to Lyon, for the next 30 days.
With a price starting from $54, Wednesday is the cheapest day for a bus from Prague to Lyon. Friday instead is the most expensive day with prices starting from $79.
Morning is the cheapest day time for bus tickets from Prague to Lyon, with $54. Evening is the most expensive time of the day with prices starting from $57.

How to save money travelling from Prague to Lyon

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Prague to Lyon in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Prague to Lyon, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Prague to Lyon are also emptier.

All bus stations and stops in Prague and Lyon

In the map below, you can see where to find all bus stations in Prague and Lyon.

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Prague to Lyon? Compare all modes of transports from Prague to Lyon.

Service and Comfort on the bus from Prague to Lyon

Want to know which seat classes are available on the buses from Prague to Lyon? Or which bus companies serve the route Prague to Lyon? Below you will find answers to your questions.

FAQs about the Prague to Lyon bus

How much does a Prague Lyon bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $54 and takes 19h 35m to reach Lyon. Compare offers to save money!

How much could I save by comparing buses from Prague to Lyon?

This route is offered by 3 companies with a range of ticket prices between $54 and $173. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Lyon.

On average, how many connections are available from Prague to Lyon each day?

Every day, the Prague to Lyon bus route is served by approximately 15 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Prague to Lyon take?

The fastest bus from Prague to Lyon is offered by FlixBus and takes 14h 35m. Bus tickets for this connection cost $89. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Prague to Lyon?

The earliest bus arriving in Lyon from Prague starts at 3:50 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Prague to Lyon?

The latest bus trip departing from Prague for Lyon starts at 11:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Prague Lyon route?

When traveling by bus from Prague to Lyon, passengers can travel with FlixBus, BlaBlaCar Bus and RegioJet. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Prague and Lyon?

You can check all the direct connections between Prague and Lyon by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus, BlaBlaCar Bus and RegioJet.

What can I take with me on the Prague to Lyon bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Prague Lyon bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Prague Lyon bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Prague to Lyon on your planned travel date.

Available seat classes which are offered on the bus route Prague to Lyon

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Prague and to Lyon

Here’s an overview of the most popular bus routes to Prague and to Lyon. Simply click on the connection of your choice, and you will find all the details about your bus route!
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Zurich to Lyon bus Zurich to Lyon bus
Bus to Lyon from Strasbourg Bus to Lyon from Strasbourg
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Popular Airport Shuttles to Prague and to Lyon
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