Compare all timetables for the bus from Prague to Lyon
Cheapest bus trips today
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FlixBus16h 45m04:15 PMPragueWilsonova Bus Station9:00 AMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 6/13/2025 4:15:00 PM to Perrache Bus Stop, Lyon (France) arriving at 6/14/2025 9:00:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 16h 45m
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FlixBus17h 0m04:00 PMPragueÚAN Florenc9:00 AMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 6/13/2025 4:00:00 PM to Perrache Bus Stop, Lyon (France) arriving at 6/14/2025 9:00:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 17h 0m
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FlixBus19h 10m01:05 PMPragueZličín8:15 AMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Zličín, Prague (Czech Republic) at 6/13/2025 1:05:00 PM to Perrache Bus Stop, Lyon (France) arriving at 6/14/2025 8:15:00 AM. 50 Economy ticket for $76 per person are available. Travel duration is 19h 10m
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BlaBlaCar Bus20h 45m08:20 AMPragueÚAN Florenc5:05 AMLyonPerrache Train Station0EconomyA Bus from BlaBlaCar Bus goes from ÚAN Florenc, Prague (Czech Republic) at 6/13/2025 8:20:00 AM to Perrache Train Station, Lyon (France) arriving at 6/14/2025 5:05:00 AM. 50 Economy ticket for $88 per person are available. Travel duration is 20h 45m
Cheapest bus trips tomorrow
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BlaBlaCar Bus16h 20m02:00 PMPragueÚAN Florenc6:20 AMLyonPerrache Bus Stop0EconomyA Bus from BlaBlaCar Bus goes from ÚAN Florenc, Prague (Czech Republic) at 6/14/2025 2:00:00 PM to Perrache Bus Stop, Lyon (France) arriving at 6/15/2025 6:20:00 AM. 50 Economy ticket for $61 per person are available. Travel duration is 16h 20m
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BlaBlaCar Bus16h 45m01:35 PMPragueÚAN Florenc6:20 AMLyonPerrache Train Station0EconomyA Bus from BlaBlaCar Bus goes from ÚAN Florenc, Prague (Czech Republic) at 6/14/2025 1:35:00 PM to Perrache Train Station, Lyon (France) arriving at 6/15/2025 6:20:00 AM. 50 Economy ticket for $61 per person are available. Travel duration is 16h 45m
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FlixBus19h 10m01:05 PMPragueWilsonova Bus Station8:15 AMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 6/14/2025 1:05:00 PM to Perrache Bus Stop, Lyon (France) arriving at 6/15/2025 8:15:00 AM. 50 Economy ticket for $64 per person are available. Travel duration is 19h 10m
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FlixBus17h 10m03:05 PMPragueZličín8:15 AMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Zličín, Prague (Czech Republic) at 6/14/2025 3:05:00 PM to Perrache Bus Stop, Lyon (France) arriving at 6/15/2025 8:15:00 AM. 50 Economy ticket for $64 per person are available. Travel duration is 17h 10m
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FlixBus19h 25m03:50 AMPragueWilsonova Bus Station11:15 PMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 6/14/2025 3:50:00 AM to Perrache Bus Stop, Lyon (France) arriving at 6/14/2025 11:15:00 PM. 50 Economy ticket for $65 per person are available. Travel duration is 19h 25m
Cheapest bus trips Sunday
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BlaBlaCar Bus16h 45m01:35 PMPragueÚAN Florenc6:20 AMLyonPerrache Train Station0EconomyA Bus from BlaBlaCar Bus goes from ÚAN Florenc, Prague (Czech Republic) at 6/15/2025 1:35:00 PM to Perrache Train Station, Lyon (France) arriving at 6/16/2025 6:20:00 AM. 50 Economy ticket for $58 per person are available. Travel duration is 16h 45m
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BlaBlaCar Bus16h 45m01:35 PMPragueÚAN Florenc6:20 AMLyonPerrache Bus Stop0EconomyA Bus from BlaBlaCar Bus goes from ÚAN Florenc, Prague (Czech Republic) at 6/15/2025 1:35:00 PM to Perrache Bus Stop, Lyon (France) arriving at 6/16/2025 6:20:00 AM. 50 Economy ticket for $58 per person are available. Travel duration is 16h 45m
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FlixBus19h 25m03:50 AMPragueWilsonova Bus Station11:15 PMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 6/15/2025 3:50:00 AM to Perrache Bus Stop, Lyon (France) arriving at 6/15/2025 11:15:00 PM. 50 Economy ticket for $78 per person are available. Travel duration is 19h 25m
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FlixBus16h 45m04:15 PMPragueWilsonova Bus Station9:00 AMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 6/15/2025 4:15:00 PM to Perrache Bus Stop, Lyon (France) arriving at 6/16/2025 9:00:00 AM. 50 Economy ticket for $78 per person are available. Travel duration is 16h 45m
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FlixBus19h 5m04:10 AMPragueNa Knížecí Station11:15 PMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 6/15/2025 4:10:00 AM to Perrache Bus Stop, Lyon (France) arriving at 6/15/2025 11:15:00 PM. 50 Economy ticket for $78 per person are available. Travel duration is 19h 5m
Cheapest bus trips Monday
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FlixBus16h 45m04:15 PMPragueWilsonova Bus Station9:00 AMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 6/16/2025 4:15:00 PM to Perrache Bus Stop, Lyon (France) arriving at 6/17/2025 9:00:00 AM. 50 Economy ticket for $63 per person are available. Travel duration is 16h 45m
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FlixBus17h 0m04:00 PMPragueÚAN Florenc9:00 AMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 6/16/2025 4:00:00 PM to Perrache Bus Stop, Lyon (France) arriving at 6/17/2025 9:00:00 AM. 50 Economy ticket for $63 per person are available. Travel duration is 17h 0m
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FlixBus16h 35m06:40 AMPragueÚAN Florenc11:15 PMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 6/16/2025 6:40:00 AM to Perrache Bus Stop, Lyon (France) arriving at 6/16/2025 11:15:00 PM. 50 Economy ticket for $65 per person are available. Travel duration is 16h 35m
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FlixBus17h 20m011:15 AMPragueWilsonova Bus Station4:35 AMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 6/16/2025 11:15:00 AM to Perrache Bus Stop, Lyon (France) arriving at 6/17/2025 4:35:00 AM. 50 Economy ticket for $66 per person are available. Travel duration is 17h 20m
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FlixBus17h 5m03:10 PMPragueÚAN Florenc8:15 AMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 6/16/2025 3:10:00 PM to Perrache Bus Stop, Lyon (France) arriving at 6/17/2025 8:15:00 AM. 50 Economy ticket for $67 per person are available. Travel duration is 17h 5m
Cheapest bus trips Tuesday
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FlixBus16h 45m04:15 PMPragueWilsonova Bus Station9:00 AMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 6/17/2025 4:15:00 PM to Perrache Bus Stop, Lyon (France) arriving at 6/18/2025 9:00:00 AM. 50 Economy ticket for $61 per person are available. Travel duration is 16h 45m
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FlixBus14h 35m09:50 PMPragueNa Knížecí Station12:25 PMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 6/17/2025 9:50:00 PM to Perrache Bus Stop, Lyon (France) arriving at 6/18/2025 12:25:00 PM. 50 Economy ticket for $61 per person are available. Travel duration is 14h 35m
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FlixBus16h 35m06:40 AMPragueÚAN Florenc11:15 PMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 6/17/2025 6:40:00 AM to Perrache Bus Stop, Lyon (France) arriving at 6/17/2025 11:15:00 PM. 50 Economy ticket for $61 per person are available. Travel duration is 16h 35m
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FlixBus17h 5m03:10 PMPragueÚAN Florenc8:15 AMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 6/17/2025 3:10:00 PM to Perrache Bus Stop, Lyon (France) arriving at 6/18/2025 8:15:00 AM. 50 Economy ticket for $61 per person are available. Travel duration is 17h 5m
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FlixBus17h 0m04:00 PMPragueÚAN Florenc9:00 AMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 6/17/2025 4:00:00 PM to Perrache Bus Stop, Lyon (France) arriving at 6/18/2025 9:00:00 AM. 50 Economy ticket for $61 per person are available. Travel duration is 17h 0m
Cheapest bus trips Wednesday
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FlixBus17h 10m03:05 PMPragueZličín8:15 AMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Zličín, Prague (Czech Republic) at 6/18/2025 3:05:00 PM to Perrache Bus Stop, Lyon (France) arriving at 6/19/2025 8:15:00 AM. 50 Economy ticket for $60 per person are available. Travel duration is 17h 10m
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FlixBus19h 10m01:05 PMPragueWilsonova Bus Station8:15 AMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 6/18/2025 1:05:00 PM to Perrache Bus Stop, Lyon (France) arriving at 6/19/2025 8:15:00 AM. 50 Economy ticket for $61 per person are available. Travel duration is 19h 10m
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FlixBus14h 35m09:50 PMPragueNa Knížecí Station12:25 PMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 6/18/2025 9:50:00 PM to Perrache Bus Stop, Lyon (France) arriving at 6/19/2025 12:25:00 PM. 50 Economy ticket for $61 per person are available. Travel duration is 14h 35m
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BlaBlaCar Bus16h 20m02:00 PMPragueÚAN Florenc6:20 AMLyonPerrache Train Station0EconomyA Bus from BlaBlaCar Bus goes from ÚAN Florenc, Prague (Czech Republic) at 6/18/2025 2:00:00 PM to Perrache Train Station, Lyon (France) arriving at 6/19/2025 6:20:00 AM. 50 Economy ticket for $61 per person are available. Travel duration is 16h 20m
Cheapest bus trips Thursday
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RegioJet15h 50m011:00 PMPragueÚAN Florenc2:50 PMLyonPerrache Bus Stop0EconomyA Bus from RegioJet goes from ÚAN Florenc, Prague (Czech Republic) at 6/19/2025 11:00:00 PM to Perrache Bus Stop, Lyon (France) arriving at 6/20/2025 2:50:00 PM. 50 Economy ticket for $57 per person are available. Travel duration is 15h 50m
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FlixBus16h 45m04:15 PMPragueWilsonova Bus Station9:00 AMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 6/19/2025 4:15:00 PM to Perrache Bus Stop, Lyon (France) arriving at 6/20/2025 9:00:00 AM. 50 Economy ticket for $59 per person are available. Travel duration is 16h 45m
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FlixBus17h 0m04:00 PMPragueÚAN Florenc9:00 AMLyonPerrache Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 6/19/2025 4:00:00 PM to Perrache Bus Stop, Lyon (France) arriving at 6/20/2025 9:00:00 AM. 50 Economy ticket for $59 per person are available. Travel duration is 17h 0m
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BlaBlaCar Bus16h 45m01:35 PMPragueÚAN Florenc6:20 AMLyonPerrache Bus Stop0EconomyA Bus from BlaBlaCar Bus goes from ÚAN Florenc, Prague (Czech Republic) at 6/19/2025 1:35:00 PM to Perrache Bus Stop, Lyon (France) arriving at 6/20/2025 6:20:00 AM. 50 Economy ticket for $61 per person are available. Travel duration is 16h 45m
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BlaBlaCar Bus16h 45m01:35 PMPragueÚAN Florenc6:20 AMLyonPerrache Train Station0EconomyA Bus from BlaBlaCar Bus goes from ÚAN Florenc, Prague (Czech Republic) at 6/19/2025 1:35:00 PM to Perrache Train Station, Lyon (France) arriving at 6/20/2025 6:20:00 AM. 50 Economy ticket for $61 per person are available. Travel duration is 16h 45m
Frequency of bus connections between Prague and Lyon
Facts about the bus from Prague to Lyon
Compare all providers like FlixBus, BlaBlaCar Bus and RegioJet that travel 14 times every day by bus from Prague to Lyon in one click! Book your bus ticket from Prague to Lyon starting from $57!
Cheapest Bus | $57 |
Fastest Bus | 14h 35m |
Earliest Bus | 3:50 AM |
Latest Bus | 11:00 PM |
Daily Bus Routes | 14 Ø |
Distance | 535.0 miles |
Bus Companies | FlixBus, BlaBlaCar Bus and RegioJet |
Cheapest bus connections from Prague to Lyon
Every day, 14 buses from 3 bus companies leave Prague for Lyon: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 06/13/2025 and for the following days.
The cheapest time to travel from Prague to Lyon
How to save money travelling from Prague to Lyon
Book the ticket from Prague to Lyon in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Prague to Lyon, compared instead if you buy it at the last moment, or directly at the station.
If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Prague to Lyon are also emptier.All bus stations and stops in Prague and Lyon
In the map below, you can see where to find all bus stations in Prague and Lyon.
Compare the bus with other modes of transport
Service and Comfort on the bus from Prague to Lyon
FAQs about the Prague to Lyon bus
How much does a Prague Lyon bus trip cost?
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On average, how many connections are available from Prague to Lyon each day?
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What equipment is available for the Prague Lyon bus route?
Available seat classes which are offered on the bus route Prague to Lyon
The cheapest option available for your ticket, it usually comes with reclinable seats and AC.
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