Bus from Prague to Lyon from $54

Compare all the bus companies and find the best price with CheckMyBus
The Best Deals Save up to 70%
The Most Choices Millions of routes worldwide
Easy and Transparent Compare offers with 1 click

Compare all timetables for the bus from Prague to Lyon

Here is a selection of the cheapest bus trips from the schedule from Prague to Lyon from various bus operators like FlixBus for the next days.

today
$70
tomorrow
$69
Monday
$65
Tuesday
$61
Wednesday
$59
Thursday
$59
Friday
$69

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 14h 50m 9:50 PM Prague Na Knížecí Station 12:40 PM Lyon Lyon Avenue Tony Garnier Bus Stop  Economy $70
FlixBus 15h 15m 9:25 PM Prague ÚAN Florenc 12:40 PM Lyon Lyon Avenue Tony Garnier Bus Stop  Economy $70
FlixBus 19h 50m 3:25 AM Prague Wilsonova Bus Station 11:15 PM Lyon Lyon Avenue Tony Garnier Bus Stop  Economy $74
FlixBus 19h 10m 1:05 PM Prague Wilsonova Bus Station 8:15 AM Lyon Lyon Avenue Tony Garnier Bus Stop  Economy $74
FlixBus 19h 35m 3:40 AM Prague Na Knížecí Station 11:15 PM Lyon Lyon Avenue Tony Garnier Bus Stop  Economy $74

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 17h 45m 2:30 PM Prague Černý Most 8:15 AM Lyon Lyon Avenue Tony Garnier Bus Stop  Economy $69
FlixBus 16h 50m 4:15 PM Prague Wilsonova Bus Station 9:05 AM Lyon Lyon Avenue Tony Garnier Bus Stop  Economy $79
FlixBus 17h 5m 3:10 PM Prague ÚAN Florenc 8:15 AM Lyon Lyon Avenue Tony Garnier Bus Stop  Economy $82
FlixBus 14h 50m 9:50 PM Prague Na Knížecí Station 12:40 PM Lyon Lyon Avenue Tony Garnier Bus Stop  Economy $85
FlixBus 15h 15m 9:25 PM Prague ÚAN Florenc 12:40 PM Lyon Lyon Avenue Tony Garnier Bus Stop  Economy $85
  • Did you know that if you travel from Prague to Lyon via Zurich, you can save more than $7? You can find the corresponding connections below.
    • FlixBus
      21h 50m
      0
      11:50 PM
      Prague
      Wilsonova Bus Station
      10:00 AM
      Zurich
      Central Bus Station Sihlquai
      0
      FlixBus
      Economy
      $40
      • Waiting Time 4h 25m
    • FlixBus
      7h 15m
      0
      2:25 PM
      Zurich
      Central Bus Station Sihlquai
      9:40 PM
      Lyon
      Lyon Avenue Tony Garnier Bus Stop
      0
      FlixBus
      Economy
      $22
    Travel time is 7h 0m longer, but you will save $7

Cheapest bus trips Monday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 14h 50m 9:50 PM Prague Na Knížecí Station 12:40 PM Lyon Lyon Avenue Tony Garnier Bus Stop  Economy $65
FlixBus 15h 15m 9:25 PM Prague ÚAN Florenc 12:40 PM Lyon Lyon Avenue Tony Garnier Bus Stop  Economy $65
FlixBus 17h 5m 3:10 PM Prague ÚAN Florenc 8:15 AM Lyon Lyon Avenue Tony Garnier Bus Stop  Economy $67
FlixBus 17h 45m 2:30 PM Prague Černý Most 8:15 AM Lyon Lyon Avenue Tony Garnier Bus Stop  Economy $67
FlixBus 19h 50m 3:25 AM Prague Wilsonova Bus Station 11:15 PM Lyon Lyon Avenue Tony Garnier Bus Stop  Economy $69

Cheapest bus trips Tuesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 17h 5m 3:10 PM Prague ÚAN Florenc 8:15 AM Lyon Lyon Avenue Tony Garnier Bus Stop  Economy $61
FlixBus 17h 45m 2:30 PM Prague Černý Most 8:15 AM Lyon Lyon Avenue Tony Garnier Bus Stop  Economy $61
FlixBus 24h 5m 12:45 PM Prague Wilsonova Bus Station 12:50 PM Lyon Lyon Avenue Tony Garnier Bus Stop  Economy $62
FlixBus 19h 10m 1:05 PM Prague Wilsonova Bus Station 8:15 AM Lyon Lyon Avenue Tony Garnier Bus Stop  Economy $62
FlixBus 17h 55m 7:30 PM Prague ÚAN Florenc 1:25 PM Lyon Lyon Avenue Tony Garnier Bus Stop  Economy $62

Cheapest bus trips Wednesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 15h 15m 9:25 PM Prague ÚAN Florenc 12:40 PM Lyon Lyon Avenue Tony Garnier Bus Stop  Economy $59
FlixBus 14h 50m 9:50 PM Prague Na Knížecí Station 12:40 PM Lyon Lyon Avenue Tony Garnier Bus Stop  Economy $59
FlixBus 17h 5m 3:10 PM Prague ÚAN Florenc 8:15 AM Lyon Lyon Avenue Tony Garnier Bus Stop  Economy $61
FlixBus 17h 45m 2:30 PM Prague Černý Most 8:15 AM Lyon Lyon Avenue Tony Garnier Bus Stop  Economy $61
FlixBus 19h 10m 1:05 PM Prague Wilsonova Bus Station 8:15 AM Lyon Lyon Avenue Tony Garnier Bus Stop  Economy $62

Cheapest bus trips Thursday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 14h 50m 9:50 PM Prague Na Knížecí Station 12:40 PM Lyon Lyon Avenue Tony Garnier Bus Stop  Economy $59
FlixBus 15h 15m 9:25 PM Prague ÚAN Florenc 12:40 PM Lyon Lyon Avenue Tony Garnier Bus Stop  Economy $59
FlixBus 16h 35m 6:40 AM Prague ÚAN Florenc 11:15 PM Lyon Lyon Avenue Tony Garnier Bus Stop  Economy $62
FlixBus 17h 5m 3:10 PM Prague ÚAN Florenc 8:15 AM Lyon Lyon Avenue Tony Garnier Bus Stop  Economy $62
FlixBus 17h 45m 2:30 PM Prague Černý Most 8:15 AM Lyon Lyon Avenue Tony Garnier Bus Stop  Economy $62

Cheapest bus trips Friday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 14h 50m 9:50 PM Prague Na Knížecí Station 12:40 PM Lyon Lyon Avenue Tony Garnier Bus Stop  Economy $69
FlixBus 15h 15m 9:25 PM Prague ÚAN Florenc 12:40 PM Lyon Lyon Avenue Tony Garnier Bus Stop  Economy $69
FlixBus 16h 35m 6:40 AM Prague ÚAN Florenc 11:15 PM Lyon Lyon Avenue Tony Garnier Bus Stop  Economy $80
FlixBus 19h 50m 3:25 AM Prague Wilsonova Bus Station 11:15 PM Lyon Lyon Avenue Tony Garnier Bus Stop  Economy $89
FlixBus 19h 35m 3:40 AM Prague Na Knížecí Station 11:15 PM Lyon Lyon Avenue Tony Garnier Bus Stop  Economy $89
  • Did you know that if you travel from Prague to Lyon via Zurich, you can save more than $8? You can find the corresponding connections below.
    • FlixBus
      18h 55m
      0
      6:30 PM
      Prague
      Wilsonova Bus Station
      4:45 AM
      Zurich
      Central Bus Station Sihlquai
      0
      FlixBus
      Economy
      $38
      • Waiting Time 1h 25m
    • FlixBus
      7h 15m
      0
      6:10 AM
      Zurich
      Central Bus Station Sihlquai
      1:25 PM
      Lyon
      Lyon Avenue Tony Garnier Bus Stop
      0
      FlixBus
      Economy
      $22
    Travel time is 4h 5m longer, but you will save $8

Best Price Offer: The price for the cheapest bus from Prague to Lyon is $54 on 10/6/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Prague and Lyon

See here how frequent the connections between Prague and Lyon are, during different times and days of the week.
Sunday is the busiest day, with more than 22 daily buses from Prague to Lyon. Wednesday has instead the fewest connections, with only 14 daily coaches between Prague and Lyon.
The busiest time of the day is the Afternoon, with 49 buses from Prague to Lyon, while Night sees the fewest connections between Prague and Lyon, with 17 offers.

Facts about the bus from Prague to Lyon

Compare all providers like FlixBus that travel 17 times every day by bus from Prague to Lyon in one click! Book your bus ticket from Prague to Lyon starting from $54!

Cheapest Bus $54
Fastest Bus 14h 50m
Earliest Bus 2:30 AM
Latest Bus 11:50 PM
Daily Bus Routes 17 Ø
Distance 535.0 miles
Bus Companies FlixBus

Cheapest bus connections from Prague to Lyon

Every day, 17 buses from 1 bus companies leave Prague for Lyon: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 09/19/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 09/13
Monday 09/14
Tuesday 09/15
Wednesday 09/16
Thursday 09/17
Friday 09/18
Saturday 09/19
$70
Sunday 09/20
$82
Monday 09/21
$65
Tuesday 09/22
$61
Wednesday 09/23
$59
Thursday 09/24
$59
Friday 09/25
$69
Saturday 09/26
$70
Sunday 09/27
$71
Monday 09/28
$61
Tuesday 09/29
$59
Wednesday 09/30
$58
Thursday 10/01
$58
Friday 10/02
$62
Saturday 10/03
$62
Sunday 10/04
$67
Monday 10/05
$56
Tuesday 10/06
$54
Wednesday 10/07
$54
Thursday 10/08
$54
Friday 10/09
$63
Saturday 10/10

The cheapest time to travel from Prague to Lyon

See here on which day and which time of the day you can find the cheapest bus ticket from Prague to Lyon, for the next 30 days.
With a price starting from $54, Tuesday is the cheapest day for a bus from Prague to Lyon. Sunday instead is the most expensive day with prices starting from $62.
Night is the cheapest day time for bus tickets from Prague to Lyon, with $54. Morning is the most expensive time of the day with prices starting from $62.

How to save money travelling from Prague to Lyon

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Prague to Lyon in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Prague to Lyon, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Prague to Lyon are also emptier.

All bus stations and stops in Prague and Lyon

In the map below, you can see where to find all bus stations in Prague and Lyon.

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Prague to Lyon? Compare all modes of transports from Prague to Lyon.

Service and Comfort on the bus from Prague to Lyon

Want to know which seat classes are available on the buses from Prague to Lyon? Or which bus companies serve the route Prague to Lyon? Below you will find answers to your questions.

FAQs about the Prague to Lyon bus

How much does a Prague Lyon bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $54 and takes 15h 15m to reach Lyon. Compare offers to save money!

How much could I save by comparing buses from Prague to Lyon?

This route is offered by 1 companies with a range of ticket prices between $54 and $162. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Lyon.

On average, how many connections are available from Prague to Lyon each day?

Every day, the Prague to Lyon bus route is served by approximately 17 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Prague to Lyon take?

The fastest bus from Prague to Lyon is offered by FlixBus and takes 14h 50m. Bus tickets for this connection cost $70. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Prague to Lyon?

The earliest bus arriving in Lyon from Prague starts at 2:30 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Prague to Lyon?

The latest bus trip departing from Prague for Lyon starts at 11:50 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Prague Lyon route?

When traveling by bus from Prague to Lyon, passengers can travel with FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Prague and Lyon?

You can check all the direct connections between Prague and Lyon by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus.

What can I take with me on the Prague to Lyon bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Prague Lyon bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Prague Lyon bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Prague to Lyon on your planned travel date.

How does CheckMyBus find the best bus deals from Prague to Lyon?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 17 daily trips between Prague and Lyon. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Prague to Lyon?

Prices and availability for 17 trips between Prague and Lyon change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Prague to Lyon

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Prague and to Lyon

Here’s an overview of the most popular bus routes to Prague and to Lyon. Simply click on the connection of your choice, and you will find all the details about your bus route!
Bus to Prague from Havlíčkův Brod Bus to Prague from Havlíčkův Brod
Uherske Hradiste to Prague bus Uherske Hradiste to Prague bus
Buses to Prague from Zilina Buses to Prague from Zilina
Bus Chisinau to Prague Bus Chisinau to Prague
Bus Naples - Lyon Bus Naples - Lyon
From Mâcon to Lyon bus From Mâcon to Lyon bus
Buses Brive-la-Gaillarde to Lyon Buses Brive-la-Gaillarde to Lyon
From La Rochelle to Lyon bus From La Rochelle to Lyon bus
Popular Airport Shuttles to Prague and to Lyon
CheckMyBus › Buses in Czech Republic › Bus to Prague › Bus to Lyon

The CheckMyBus App

Free Download

App Store
CheckMyBus App
Close
GPDR CheckMyBus shield

We value your privacy!

To

show

you

the

best

bus

offers,

we

and

our

partners

use

technical,

analytical,

and

marketing

cookies

to

personalize

the

ads.

We

remember

your

anonymized

details

to

provide

a

personalized

experience.