Bus Prague to Lyon: Compare prices and save money

Compare all timetables for the bus from Prague to Lyon

Here is a selection of the cheapest bus trips from the schedule from Prague to Lyon from various bus operators like FlixBus or RegioJet for the next days.

today

tomorrow

Thursday

$59

Friday

Saturday

Sunday

Monday

$60

Cheapest bus trips Thursday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	RegioJet	15h 50m	11:00 PM	Prague	ÚAN Florenc	2:50 PM	Lyon	Perrache Bus Stop		Economy	$59	A Bus from RegioJet goes from ÚAN Florenc, Prague (Czech Republic) at 2/5/2026 11:00:00 PM to Perrache Bus Stop, Lyon (France) arriving at 2/6/2026 2:50:00 PM. 50 Economy ticket for $59 per person are available. Travel duration is 15h 50m

Cheapest bus trips Monday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	19h 55m	8:50 AM	Prague	ÚAN Florenc	4:45 AM	Lyon	Perrache Bus Stop		Economy	$60	A Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 2/9/2026 8:50:00 AM to Perrache Bus Stop, Lyon (France) arriving at 2/10/2026 4:45:00 AM. 50 Economy ticket for $60 per person are available. Travel duration is 19h 55m
	FlixBus	19h 35m	9:10 AM	Prague	Na Knížecí Station	4:45 AM	Lyon	Perrache Bus Stop		Economy	$60	A Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 2/9/2026 9:10:00 AM to Perrache Bus Stop, Lyon (France) arriving at 2/10/2026 4:45:00 AM. 50 Economy ticket for $60 per person are available. Travel duration is 19h 35m

Best Price Offer: The price for the cheapest bus from Prague to Lyon is $52 on 2/25/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Prague and Lyon

See here how frequent the connections between Prague and Lyon are, during different times and days of the week.

Monday is the busiest day, with more than 2 daily buses from Prague to Lyon. Thursday has instead the fewest connections, with only 1 daily coaches between Prague and Lyon.

The busiest time of the day is the Morning, with 2 buses from Prague to Lyon, while Evening sees the fewest connections between Prague and Lyon, with 1 offers.

Facts about the bus from Prague to Lyon

Compare all providers like FlixBus and RegioJet that travel 1 times every day by bus from Prague to Lyon in one click! Book your bus ticket from Prague to Lyon starting from $52!

Cheapest Bus	$52
Fastest Bus	15h 50m
Earliest Bus	11:00 PM
Latest Bus	9:10 AM
Daily Bus Routes	1 Ø
Distance	535.0 miles
Bus Companies	FlixBus and RegioJet

Cheapest bus connections from Prague to Lyon

Every day, 1 buses from 2 bus companies leave Prague for Lyon: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 02/03/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 02/01

Monday 02/02

Tuesday 02/03

$73

Wednesday 02/04

$72

Thursday 02/05

$61

Friday 02/06

$69

Saturday 02/07

$71

Sunday 02/08

$69

Monday 02/09

$62

Tuesday 02/10

$59

Wednesday 02/11

$58

Thursday 02/12

$59

Friday 02/13

$64

Saturday 02/14

$63

Sunday 02/15

$64

Monday 02/16

$59

Tuesday 02/17

$57

Wednesday 02/18

$57

Thursday 02/19

$56

Friday 02/20

$63

Saturday 02/21

$65

Sunday 02/22

$63

Monday 02/23

$54

Tuesday 02/24

$54

Wednesday 02/25

$52

Thursday 02/26

$54

Friday 02/27

$57

Saturday 02/28

The cheapest time to travel from Prague to Lyon

See here on which day and which time of the day you can find the cheapest bus ticket from Prague to Lyon, for the next 30 days.

With a price starting from $54, Monday is the cheapest day for a bus from Prague to Lyon. Thursday instead is the most expensive day with prices starting from $54.

Evening is the cheapest day time for bus tickets from Prague to Lyon, with $58. Morning is the most expensive time of the day with prices starting from $60.

How to save money travelling from Prague to Lyon

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Prague to Lyon in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Prague to Lyon, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Prague to Lyon are also emptier.

Beloved bus companies from Prague to Lyon

These are the most booked bus companies between Prague to Lyon from our users.

FlixBus from Prague to Lyon

Here you will find the key facts about the FlixBus bus route Prague to Lyon:

Cheapest Price	$60
Fastest Bus	19h 35m
Earliest Bus	8:50 AM
Last Bus	9:10 AM
Daily Connections	2 Ø
Found on	1/12/2026

All bus stations and stops in Prague and Lyon

In the map below, you can see where to find all bus stations in Prague and Lyon.

Na Knížecí Station

Za Ženskými domovy / Ostrovského

ÚAN Florenc

Křižíkova 279

Wilsonova Bus Station

Wilsonova 300/8

Roztyly

Tomíčkova 2234

Černý Most

Bryksova

Perrache Bus Stop

Cours de Verdun 14

Pont Kitchener R.G. Bus Stop

Cours de Verdun

Maison Carrée Bus Stop

Les Charrières 69570

Girondins - Yves Farge Bus Stop

Saint Paul Train Station

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Prague to Lyon? Compare all modes of transports from Prague to Lyon.

Service and Comfort on the bus from Prague to Lyon

Want to know which seat classes are available on the buses from Prague to Lyon? Or which bus companies serve the route Prague to Lyon? Below you will find answers to your questions.

FAQs about the Prague to Lyon bus

How much does a Prague Lyon bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $52 and takes 15h 50m to reach Lyon. Compare offers to save money!

How much could I save by comparing buses from Prague to Lyon?

This route is offered by 2 companies with a range of ticket prices between $52 and $60. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Lyon.

On average, how many connections are available from Prague to Lyon each day?

Every day, the Prague to Lyon bus route is served by approximately 1 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Prague to Lyon take?

The fastest bus from Prague to Lyon is offered by RegioJet and takes 15h 50m. Bus tickets for this connection cost $59. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Prague to Lyon?

The earliest bus arriving in Lyon from Prague starts at 11:00 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Prague to Lyon?

The latest bus trip departing from Prague for Lyon starts at 9:10 AM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Prague Lyon route?

When traveling by bus from Prague to Lyon, passengers can travel with FlixBus and RegioJet. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Prague and Lyon?

You can check all the direct connections between Prague and Lyon by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and RegioJet.

What can I take with me on the Prague to Lyon bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Prague Lyon bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Prague Lyon bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Prague to Lyon on your planned travel date.

How does CheckMyBus find the best bus deals from Prague to Lyon?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 1 daily trips between Prague and Lyon. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Prague to Lyon?

Prices and availability for 1 trips between Prague and Lyon change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Prague to Lyon

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Prague and to Lyon

Here’s an overview of the most popular bus routes to Prague and to Lyon. Simply click on the connection of your choice, and you will find all the details about your bus route!