What is the best way to travel from Prague to Lyon?
Looking for a trip? Compare all the available Trains, Flights and Buses for the journey to Lyon from Prague. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
What is the cheapest way to reach Lyon from Prague?
You can get to Lyon with just $51 by taking a Bus from FlixBus, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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FlixBus16h 50m04:15 PMPragueWilsonova Bus Station9:05 AMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 11/2/2026 4:15:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/3/2026 9:05:00 AM. 50 Economy ticket for $74 per person are available. Travel duration is 16h 50m
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FlixBus16h 35m06:40 AMPragueÚAN Florenc11:15 PMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 11/2/2026 6:40:00 AM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/2/2026 11:15:00 PM. 50 Economy ticket for $77 per person are available. Travel duration is 16h 35m
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FlixBus17h 5m04:00 PMPragueÚAN Florenc9:05 AMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 11/2/2026 4:00:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/3/2026 9:05:00 AM. 50 Economy ticket for $77 per person are available. Travel duration is 17h 5m
Cheapest Buses Monday
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FlixBus17h 5m03:10 PMPragueÚAN Florenc8:15 AMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 11/3/2026 3:10:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/4/2026 8:15:00 AM. 50 Economy ticket for $65 per person are available. Travel duration is 17h 5m
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FlixBus17h 45m02:30 PMPragueČerný Most8:15 AMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from Černý Most, Prague (Czech Republic) at 11/3/2026 2:30:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/4/2026 8:15:00 AM. 50 Economy ticket for $65 per person are available. Travel duration is 17h 45m
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FlixBus19h 15m07:30 PMPragueÚAN Florenc2:45 PMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 11/3/2026 7:30:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/4/2026 2:45:00 PM. 50 Economy ticket for $71 per person are available. Travel duration is 19h 15m
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FlixBus21h 0m05:45 PMPrague AirportPrague Airport - T1/22:45 PMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 11/3/2026 5:45:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/4/2026 2:45:00 PM. 50 Economy ticket for $71 per person are available. Travel duration is 21h 0m
Cheapest Buses Tuesday
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FlixBus17h 5m03:10 PMPragueÚAN Florenc8:15 AMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 11/4/2026 3:10:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/5/2026 8:15:00 AM. 50 Economy ticket for $51 per person are available. Travel duration is 17h 5m
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FlixBus17h 45m02:30 PMPragueČerný Most8:15 AMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from Černý Most, Prague (Czech Republic) at 11/4/2026 2:30:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/5/2026 8:15:00 AM. 50 Economy ticket for $51 per person are available. Travel duration is 17h 45m
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FlixBus15h 15m09:25 PMPragueÚAN Florenc12:40 PMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 11/4/2026 9:25:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/5/2026 12:40:00 PM. 50 Economy ticket for $54 per person are available. Travel duration is 15h 15m
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FlixBus14h 50m09:50 PMPragueNa Knížecí Station12:40 PMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 11/4/2026 9:50:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/5/2026 12:40:00 PM. 50 Economy ticket for $54 per person are available. Travel duration is 14h 50m
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Wizz Air23h 55m05:00 PMPrague AirportPrague Airport4:55 PMLyons St. Exupery AirportLyons St. Exupery Airport0EconomyA Flight from Wizz Air goes from Prague Airport, Prague Airport (Czech Republic) at 11/4/2026 5:00:00 PM to Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) arriving at 11/5/2026 4:55:00 PM. 50 Economy ticket for $69 per person are available. Travel duration is 23h 55m
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EasyJet Airline20h 0m08:55 PMPrague AirportPrague Airport4:55 PMLyons St. Exupery AirportLyons St. Exupery Airport0EconomyA Flight from EasyJet Airline goes from Prague Airport, Prague Airport (Czech Republic) at 11/4/2026 8:55:00 PM to Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) arriving at 11/5/2026 4:55:00 PM. 50 Economy ticket for $89 per person are available. Travel duration is 20h 0m
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Pegasus Group LTD19h 30m06:15 PMPrague AirportPrague Airport1:45 PMLyons St. Exupery AirportLyons St. Exupery Airport0EconomyA Flight from Pegasus Group LTD goes from Prague Airport, Prague Airport (Czech Republic) at 11/4/2026 6:15:00 PM to Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) arriving at 11/5/2026 1:45:00 PM. 50 Economy ticket for $166 per person are available. Travel duration is 19h 30m
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Smartwings11h 10m011:45 AMPrague AirportPrague Airport10:55 PMLyons St. Exupery AirportLyons St. Exupery Airport0EconomyA Flight from Smartwings goes from Prague Airport, Prague Airport (Czech Republic) at 11/4/2026 11:45:00 AM to Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) arriving at 11/4/2026 10:55:00 PM. 50 Economy ticket for $177 per person are available. Travel duration is 11h 10m
Cheapest Buses Wednesday
Cheapest Flights Wednesday
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FlixBus16h 35m06:40 AMPragueÚAN Florenc11:15 PMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 11/5/2026 6:40:00 AM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/5/2026 11:15:00 PM. 50 Economy ticket for $59 per person are available. Travel duration is 16h 35m
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FlixBus17h 45m02:30 PMPragueČerný Most8:15 AMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from Černý Most, Prague (Czech Republic) at 11/5/2026 2:30:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/6/2026 8:15:00 AM. 50 Economy ticket for $59 per person are available. Travel duration is 17h 45m
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FlixBus16h 50m04:15 PMPragueWilsonova Bus Station9:05 AMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 11/5/2026 4:15:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/6/2026 9:05:00 AM. 50 Economy ticket for $63 per person are available. Travel duration is 16h 50m
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FlixBus14h 50m09:50 PMPragueNa Knížecí Station12:40 PMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 11/5/2026 9:50:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/6/2026 12:40:00 PM. 50 Economy ticket for $63 per person are available. Travel duration is 14h 50m
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EasyJet Airline1h 50m012:30 PMPrague AirportPrague Airport2:20 PMLyons St. Exupery AirportLyons St. Exupery Airport0EconomyA Flight from EasyJet Airline goes from Prague Airport, Prague Airport (Czech Republic) at 11/5/2026 12:30:00 PM to Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) arriving at 11/5/2026 2:20:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 1h 50m
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Wizz Air22h 0m010:45 PMPrague AirportPrague Airport8:45 PMLyons St. Exupery AirportLyons St. Exupery Airport0EconomyA Flight from Wizz Air goes from Prague Airport, Prague Airport (Czech Republic) at 11/5/2026 10:45:00 PM to Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) arriving at 11/6/2026 8:45:00 PM. 50 Economy ticket for $100 per person are available. Travel duration is 22h 0m
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Vueling Airlines11h 40m08:55 PMPrague AirportPrague Airport8:35 AMLyons St. Exupery AirportLyons St. Exupery Airport0EconomyA Flight from Vueling Airlines goes from Prague Airport, Prague Airport (Czech Republic) at 11/5/2026 8:55:00 PM to Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) arriving at 11/6/2026 8:35:00 AM. 50 Economy ticket for $105 per person are available. Travel duration is 11h 40m
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Smartwings12h 30m011:20 AMPrague AirportPrague Airport11:50 PMLyons St. Exupery AirportLyons St. Exupery Airport0EconomyA Flight from Smartwings goes from Prague Airport, Prague Airport (Czech Republic) at 11/5/2026 11:20:00 AM to Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) arriving at 11/5/2026 11:50:00 PM. 50 Economy ticket for $182 per person are available. Travel duration is 12h 30m
Cheapest Buses Thursday
Cheapest Flights Thursday
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FlixBus14h 50m09:50 PMPragueNa Knížecí Station12:40 PMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 11/6/2026 9:50:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/7/2026 12:40:00 PM. 50 Economy ticket for $61 per person are available. Travel duration is 14h 50m
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FlixBus16h 35m06:40 AMPragueÚAN Florenc11:15 PMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 11/6/2026 6:40:00 AM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/6/2026 11:15:00 PM. 50 Economy ticket for $61 per person are available. Travel duration is 16h 35m
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FlixBus15h 15m09:25 PMPragueÚAN Florenc12:40 PMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 11/6/2026 9:25:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/7/2026 12:40:00 PM. 50 Economy ticket for $61 per person are available. Travel duration is 15h 15m
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FlixBus16h 50m04:15 PMPragueWilsonova Bus Station9:05 AMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 11/6/2026 4:15:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/7/2026 9:05:00 AM. 50 Economy ticket for $63 per person are available. Travel duration is 16h 50m
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EasyJet Airline1h 50m010:15 AMPrague AirportPrague Airport12:05 PMLyons St. Exupery AirportLyons St. Exupery Airport0EconomyA Flight from EasyJet Airline goes from Prague Airport, Prague Airport (Czech Republic) at 11/6/2026 10:15:00 AM to Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) arriving at 11/6/2026 12:05:00 PM. 50 Economy ticket for $67 per person are available. Travel duration is 1h 50m
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Vueling Airlines10h 30m010:45 AMPrague AirportPrague Airport9:15 PMLyons St. Exupery AirportLyons St. Exupery Airport0EconomyA Flight from Vueling Airlines goes from Prague Airport, Prague Airport (Czech Republic) at 11/6/2026 10:45:00 AM to Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) arriving at 11/6/2026 9:15:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 10h 30m
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Wizz Air23h 50m010:45 PMPrague AirportPrague Airport10:35 PMLyons St. Exupery AirportLyons St. Exupery Airport0EconomyA Flight from Wizz Air goes from Prague Airport, Prague Airport (Czech Republic) at 11/6/2026 10:45:00 PM to Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) arriving at 11/7/2026 10:35:00 PM. 50 Economy ticket for $132 per person are available. Travel duration is 23h 50m
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Smartwings9h 40m011:35 AMPrague AirportPrague Airport9:15 PMLyons St. Exupery AirportLyons St. Exupery Airport0EconomyA Flight from Smartwings goes from Prague Airport, Prague Airport (Czech Republic) at 11/6/2026 11:35:00 AM to Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) arriving at 11/6/2026 9:15:00 PM. 50 Economy ticket for $174 per person are available. Travel duration is 9h 40m
Cheapest Buses Friday
Cheapest Flights Friday
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FlixBus16h 35m06:40 AMPragueÚAN Florenc11:15 PMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 11/7/2026 6:40:00 AM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/7/2026 11:15:00 PM. 50 Economy ticket for $59 per person are available. Travel duration is 16h 35m
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FlixBus14h 50m09:50 PMPragueNa Knížecí Station12:40 PMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 11/7/2026 9:50:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/8/2026 12:40:00 PM. 50 Economy ticket for $61 per person are available. Travel duration is 14h 50m
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FlixBus15h 15m09:25 PMPragueÚAN Florenc12:40 PMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 11/7/2026 9:25:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/8/2026 12:40:00 PM. 50 Economy ticket for $61 per person are available. Travel duration is 15h 15m
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FlixBus17h 50m06:30 AMPrague AirportPrague Airport - T1/212:20 AMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 11/7/2026 6:30:00 AM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/8/2026 12:20:00 AM. 50 Economy ticket for $61 per person are available. Travel duration is 17h 50m
Cheapest Buses Saturday
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FlixBus16h 35m06:40 AMPragueÚAN Florenc11:15 PMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 11/8/2026 6:40:00 AM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/8/2026 11:15:00 PM. 50 Economy ticket for $70 per person are available. Travel duration is 16h 35m
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FlixBus14h 50m09:50 PMPragueNa Knížecí Station12:40 PMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 11/8/2026 9:50:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/9/2026 12:40:00 PM. 50 Economy ticket for $80 per person are available. Travel duration is 14h 50m
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FlixBus15h 15m09:25 PMPragueÚAN Florenc12:40 PMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 11/8/2026 9:25:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/9/2026 12:40:00 PM. 50 Economy ticket for $80 per person are available. Travel duration is 15h 15m
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FlixBus22h 5m010:45 PMPrague AirportPrague Airport - T1/28:50 PMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 11/8/2026 10:45:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/9/2026 8:50:00 PM. 50 Economy ticket for $82 per person are available. Travel duration is 22h 5m
Cheapest Buses Sunday
What are the fastest trips from Prague to Lyon?
You can get to Lyon from Prague in just 1h 50m with a Flight from EasyJet Airline. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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FlixBus16h 35m06:40 AMPragueÚAN Florenc11:15 PMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 11/2/2026 6:40:00 AM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/2/2026 11:15:00 PM. 50 Economy ticket for $77 per person are available. Travel duration is 16h 35m
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FlixBus16h 50m04:15 PMPragueWilsonova Bus Station9:05 AMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 11/2/2026 4:15:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/3/2026 9:05:00 AM. 50 Economy ticket for $74 per person are available. Travel duration is 16h 50m
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FlixBus17h 5m04:00 PMPragueÚAN Florenc9:05 AMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 11/2/2026 4:00:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/3/2026 9:05:00 AM. 50 Economy ticket for $77 per person are available. Travel duration is 17h 5m
Fastest Buses Monday
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FlixBus17h 5m03:10 PMPragueÚAN Florenc8:15 AMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 11/3/2026 3:10:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/4/2026 8:15:00 AM. 50 Economy ticket for $65 per person are available. Travel duration is 17h 5m
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FlixBus17h 45m02:30 PMPragueČerný Most8:15 AMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from Černý Most, Prague (Czech Republic) at 11/3/2026 2:30:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/4/2026 8:15:00 AM. 50 Economy ticket for $65 per person are available. Travel duration is 17h 45m
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FlixBus19h 15m07:30 PMPragueÚAN Florenc2:45 PMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 11/3/2026 7:30:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/4/2026 2:45:00 PM. 50 Economy ticket for $71 per person are available. Travel duration is 19h 15m
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FlixBus21h 0m05:45 PMPrague AirportPrague Airport - T1/22:45 PMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 11/3/2026 5:45:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/4/2026 2:45:00 PM. 50 Economy ticket for $71 per person are available. Travel duration is 21h 0m
Fastest Buses Tuesday
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Lufthansa6h 5m06:10 AMPrague AirportPrague Airport12:15 PMLyons St. Exupery AirportLyons St. Exupery Airport0EconomyA Flight from Lufthansa goes from Prague Airport, Prague Airport (Czech Republic) at 11/4/2026 6:10:00 AM to Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) arriving at 11/4/2026 12:15:00 PM. 50 Economy ticket for $182 per person are available. Travel duration is 6h 5m
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Smartwings11h 10m011:45 AMPrague AirportPrague Airport10:55 PMLyons St. Exupery AirportLyons St. Exupery Airport0EconomyA Flight from Smartwings goes from Prague Airport, Prague Airport (Czech Republic) at 11/4/2026 11:45:00 AM to Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) arriving at 11/4/2026 10:55:00 PM. 50 Economy ticket for $177 per person are available. Travel duration is 11h 10m
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Pegasus Group LTD19h 30m06:15 PMPrague AirportPrague Airport1:45 PMLyons St. Exupery AirportLyons St. Exupery Airport0EconomyA Flight from Pegasus Group LTD goes from Prague Airport, Prague Airport (Czech Republic) at 11/4/2026 6:15:00 PM to Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) arriving at 11/5/2026 1:45:00 PM. 50 Economy ticket for $166 per person are available. Travel duration is 19h 30m
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EasyJet Airline20h 0m08:55 PMPrague AirportPrague Airport4:55 PMLyons St. Exupery AirportLyons St. Exupery Airport0EconomyA Flight from EasyJet Airline goes from Prague Airport, Prague Airport (Czech Republic) at 11/4/2026 8:55:00 PM to Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) arriving at 11/5/2026 4:55:00 PM. 50 Economy ticket for $89 per person are available. Travel duration is 20h 0m
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FlixBus14h 50m09:50 PMPragueNa Knížecí Station12:40 PMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 11/4/2026 9:50:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/5/2026 12:40:00 PM. 50 Economy ticket for $54 per person are available. Travel duration is 14h 50m
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FlixBus15h 15m09:25 PMPragueÚAN Florenc12:40 PMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 11/4/2026 9:25:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/5/2026 12:40:00 PM. 50 Economy ticket for $54 per person are available. Travel duration is 15h 15m
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FlixBus17h 5m03:10 PMPragueÚAN Florenc8:15 AMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 11/4/2026 3:10:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/5/2026 8:15:00 AM. 50 Economy ticket for $51 per person are available. Travel duration is 17h 5m
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FlixBus17h 45m02:30 PMPragueČerný Most8:15 AMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from Černý Most, Prague (Czech Republic) at 11/4/2026 2:30:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/5/2026 8:15:00 AM. 50 Economy ticket for $51 per person are available. Travel duration is 17h 45m
Fastest Flights Wednesday
Fastest Buses Wednesday
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EasyJet Airline1h 50m012:30 PMPrague AirportPrague Airport2:20 PMLyons St. Exupery AirportLyons St. Exupery Airport0EconomyA Flight from EasyJet Airline goes from Prague Airport, Prague Airport (Czech Republic) at 11/5/2026 12:30:00 PM to Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) arriving at 11/5/2026 2:20:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 1h 50m
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Austrian Airlines4h 40m07:25 AMPrague AirportPrague Airport12:05 PMLyons St. Exupery AirportLyons St. Exupery Airport0EconomyA Flight from Austrian Airlines goes from Prague Airport, Prague Airport (Czech Republic) at 11/5/2026 7:25:00 AM to Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) arriving at 11/5/2026 12:05:00 PM. 50 Economy ticket for $184 per person are available. Travel duration is 4h 40m
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Vueling Airlines11h 40m08:55 PMPrague AirportPrague Airport8:35 AMLyons St. Exupery AirportLyons St. Exupery Airport0EconomyA Flight from Vueling Airlines goes from Prague Airport, Prague Airport (Czech Republic) at 11/5/2026 8:55:00 PM to Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) arriving at 11/6/2026 8:35:00 AM. 50 Economy ticket for $105 per person are available. Travel duration is 11h 40m
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Smartwings12h 30m011:20 AMPrague AirportPrague Airport11:50 PMLyons St. Exupery AirportLyons St. Exupery Airport0EconomyA Flight from Smartwings goes from Prague Airport, Prague Airport (Czech Republic) at 11/5/2026 11:20:00 AM to Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) arriving at 11/5/2026 11:50:00 PM. 50 Economy ticket for $182 per person are available. Travel duration is 12h 30m
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FlixBus14h 50m09:50 PMPragueNa Knížecí Station12:40 PMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 11/5/2026 9:50:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/6/2026 12:40:00 PM. 50 Economy ticket for $63 per person are available. Travel duration is 14h 50m
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FlixBus16h 35m06:40 AMPragueÚAN Florenc11:15 PMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 11/5/2026 6:40:00 AM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/5/2026 11:15:00 PM. 50 Economy ticket for $59 per person are available. Travel duration is 16h 35m
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FlixBus16h 50m04:15 PMPragueWilsonova Bus Station9:05 AMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 11/5/2026 4:15:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/6/2026 9:05:00 AM. 50 Economy ticket for $63 per person are available. Travel duration is 16h 50m
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FlixBus17h 5m04:00 PMPragueÚAN Florenc9:05 AMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 11/5/2026 4:00:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/6/2026 9:05:00 AM. 50 Economy ticket for $63 per person are available. Travel duration is 17h 5m
Fastest Flights Thursday
Fastest Buses Thursday
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EasyJet Airline1h 50m010:15 AMPrague AirportPrague Airport12:05 PMLyons St. Exupery AirportLyons St. Exupery Airport0EconomyA Flight from EasyJet Airline goes from Prague Airport, Prague Airport (Czech Republic) at 11/6/2026 10:15:00 AM to Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) arriving at 11/6/2026 12:05:00 PM. 50 Economy ticket for $67 per person are available. Travel duration is 1h 50m
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Lufthansa7h 5m06:10 AMPrague AirportPrague Airport1:15 PMLyons St. Exupery AirportLyons St. Exupery Airport0EconomyA Flight from Lufthansa goes from Prague Airport, Prague Airport (Czech Republic) at 11/6/2026 6:10:00 AM to Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) arriving at 11/6/2026 1:15:00 PM. 50 Economy ticket for $182 per person are available. Travel duration is 7h 5m
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Smartwings9h 40m011:35 AMPrague AirportPrague Airport9:15 PMLyons St. Exupery AirportLyons St. Exupery Airport0EconomyA Flight from Smartwings goes from Prague Airport, Prague Airport (Czech Republic) at 11/6/2026 11:35:00 AM to Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) arriving at 11/6/2026 9:15:00 PM. 50 Economy ticket for $174 per person are available. Travel duration is 9h 40m
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Vueling Airlines10h 30m010:45 AMPrague AirportPrague Airport9:15 PMLyons St. Exupery AirportLyons St. Exupery Airport0EconomyA Flight from Vueling Airlines goes from Prague Airport, Prague Airport (Czech Republic) at 11/6/2026 10:45:00 AM to Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) arriving at 11/6/2026 9:15:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 10h 30m
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FlixBus14h 50m09:50 PMPragueNa Knížecí Station12:40 PMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 11/6/2026 9:50:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/7/2026 12:40:00 PM. 50 Economy ticket for $61 per person are available. Travel duration is 14h 50m
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FlixBus15h 15m09:25 PMPragueÚAN Florenc12:40 PMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 11/6/2026 9:25:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/7/2026 12:40:00 PM. 50 Economy ticket for $61 per person are available. Travel duration is 15h 15m
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FlixBus16h 35m06:40 AMPragueÚAN Florenc11:15 PMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 11/6/2026 6:40:00 AM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/6/2026 11:15:00 PM. 50 Economy ticket for $61 per person are available. Travel duration is 16h 35m
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FlixBus16h 50m04:15 PMPragueWilsonova Bus Station9:05 AMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 11/6/2026 4:15:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/7/2026 9:05:00 AM. 50 Economy ticket for $63 per person are available. Travel duration is 16h 50m
Fastest Flights Friday
Fastest Buses Friday
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FlixBus14h 50m09:50 PMPragueNa Knížecí Station12:40 PMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 11/7/2026 9:50:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/8/2026 12:40:00 PM. 50 Economy ticket for $61 per person are available. Travel duration is 14h 50m
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FlixBus15h 15m09:25 PMPragueÚAN Florenc12:40 PMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 11/7/2026 9:25:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/8/2026 12:40:00 PM. 50 Economy ticket for $61 per person are available. Travel duration is 15h 15m
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FlixBus16h 35m06:40 AMPragueÚAN Florenc11:15 PMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 11/7/2026 6:40:00 AM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/7/2026 11:15:00 PM. 50 Economy ticket for $59 per person are available. Travel duration is 16h 35m
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FlixBus17h 50m06:30 AMPrague AirportPrague Airport - T1/212:20 AMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from Prague Airport - T1/2, Prague Airport (Czech Republic) at 11/7/2026 6:30:00 AM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/8/2026 12:20:00 AM. 50 Economy ticket for $61 per person are available. Travel duration is 17h 50m
Fastest Buses Saturday
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FlixBus14h 50m09:50 PMPragueNa Knížecí Station12:40 PMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from Na Knížecí Station, Prague (Czech Republic) at 11/8/2026 9:50:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/9/2026 12:40:00 PM. 50 Economy ticket for $80 per person are available. Travel duration is 14h 50m
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FlixBus15h 15m09:25 PMPragueÚAN Florenc12:40 PMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 11/8/2026 9:25:00 PM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/9/2026 12:40:00 PM. 50 Economy ticket for $80 per person are available. Travel duration is 15h 15m
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FlixBus16h 35m06:40 AMPragueÚAN Florenc11:15 PMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from ÚAN Florenc, Prague (Czech Republic) at 11/8/2026 6:40:00 AM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/8/2026 11:15:00 PM. 50 Economy ticket for $70 per person are available. Travel duration is 16h 35m
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FlixBus19h 50m03:25 AMPragueWilsonova Bus Station11:15 PMLyonLyon Avenue Tony Garnier Bus Stop0EconomyA Bus from FlixBus goes from Wilsonova Bus Station, Prague (Czech Republic) at 11/8/2026 3:25:00 AM to Lyon Avenue Tony Garnier Bus Stop, Lyon (France) arriving at 11/8/2026 11:15:00 PM. 50 Economy ticket for $86 per person are available. Travel duration is 19h 50m
Fastest Buses Sunday
Here you will find all operators and timetables for a
Bus from Prague to Lyon
What are the most popular stations in Prague and Lyon?
In Prague, you will usually depart from Wilsonova Bus Station, ÚAN Florenc or Roztyly, while in Lyon you will be arriving at Part-Dieu Train Station, Perrache Train Station or Perrache Bus Stop, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Lyon from Prague? With 7 connections between 2 Train, Flight and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Prague and Lyon, you can pay as low as $51 with a Bus from FlixBus.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from EasyJet Airline: you will get to Lyon in just 1h 50m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Prague and Lyon are FlixBus, Wizz Air and EasyJet Airline, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Prague and Lyon is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Horoměřice or to Caluire-et-Cuire, and look at flights from Prague Airport, and landing at Lyons St. Exupery Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Prague to Lyon?
The most popular companies between Prague and Lyon, are FlixBus, Wizz Air and EasyJet Airline. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus
Airlines: Wizz Air, EasyJet Airline, Smartwings and 4 more.
All you need to know when you travel from Prague to Lyon
Check all information on comfort and services on all modes of transports from Prague to Lyon. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Prague to Lyon
How can I reach Lyon from Prague?
Every day, there are on average 7 connections between Train, Flight and Bus, with which you can get to Lyon from Prague.
How far is Lyon from Prague?
The distance between Prague and Lyon is 535.0 miles.
What is the most ecofriendly mode of transport between Prague and Lyon?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 23 kgs of CO2, a train 30 kgs, a car 146 kgs, and a flight 212 kgs.
What is the cheapest mode of transport from Prague to Lyon?
You can get to Lyon with just $51 by taking a Bus from FlixBus.
What is the fastest way to get from Prague to Lyon?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Lyon in just 1h 50m with a Flight from EasyJet Airline.
More routes to Prague and to Lyon
Looking for more options? Here you can see the most popular routes to Prague and to Lyon. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Prague
- Amsterdam to Prague
- Berlin to Prague
- Bratislava to Prague
- Brno to Prague
- Budapest to Prague
- Cheb to Prague
- Dresden to Prague
- Dusseldorf to Prague
- Frankfurt am Main to Prague
- Hamburg to Prague
- Hanover to Prague
- Hradec Kralove to Prague
- Karlovy Vary to Prague
- Krakow to Prague
- London to Prague
- Manchester to Prague
- Munich to Prague
- Nuremberg to Prague
- Pilsen to Prague
- Prague Airport to Prague
- Presov to Prague
- Salzburg to Prague
- Venice to Prague
- Vienna to Prague
- Trips to Lyon
- Annecy to Lyon
- Barcelona to Lyon
- Bern to Lyon
- Bologna to Lyon
- Bordeaux to Lyon
- Caen to Lyon
- Fréjus to Lyon
- Geneva Airport to Lyon
- Grenoble to Lyon
- Lausanne to Lyon
- Madrid to Lyon
- Massy to Lyon
- Milan to Lyon
- Montpellier to Lyon
- Moulins to Lyon
- Mulhouse to Lyon
- Munich to Lyon
- Nantes to Lyon
- Nimes to Lyon
- Paris to Lyon
- Rennes to Lyon
- Rouen to Lyon
- Viseu to Lyon
- Zurich to Lyon
