Bus from Rome to Prague from $83

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Compare all timetables for the bus from Rome to Prague

Here is a selection of the cheapest bus trips from the schedule from Rome to Prague from various bus operators like FlixBus or RegioJet for the next days.
today
from $130
tomorrow
from $97
Tuesday
from $86
Wednesday
from $83
Thursday
from $91
Friday
from $97
Saturday
from $104

Cheapest bus trips today

Prices are for one way and one person
  • FlixBus
    20h 45m
    0
    5:05 PM
    Rome
    Tiburtina Bus Station
    1:50 PM
    Prague
    ÚAN Florenc
    0
    FlixBus
    Economy
    $130
  • FlixBus
    20h 35m
    0
    5:05 PM
    Rome
    Tiburtina Bus Station
    1:40 PM
    Prague
    Wilsonova Bus Station
    0
    FlixBus
    Economy
    $130
  • FlixBus
    25h 15m
    0
    9:00 PM
    Rome
    Tiburtina Bus Station
    10:15 PM
    Prague
    Roztyly
    0
    FlixBus
    Economy
    $139
  • FlixBus
    26h 55m
    0
    9:00 PM
    Rome
    Tiburtina Bus Station
    11:55 PM
    Prague
    Wilsonova Bus Station
    0
    FlixBus
    Economy
    $141
  • FlixBus
    23h 20m
    0
    9:00 PM
    Rome
    Tiburtina Bus Station
    8:20 PM
    Prague
    Na Knížecí Station
    0
    FlixBus
    Economy
    $142
  • Did you know that if you travel from Rome to Prague via Assisi, you can save more than $24? You can find the corresponding connections below.
    • Autolinee Sulga
      25h 40m
      0
      10:30 AM
      Rome
      Tiburtina Bus Station
      1:15 PM
      Assisi
      S.Francesco Assisi Bus Stop
      0
      Autolinee Sulga
      Economy
      $19
      • Waiting Time 2h 50m
    • FlixBus
      20h 5m
      0
      4:05 PM
      Assisi
      Bus Stop
      12:10 PM
      Prague
      Wilsonova Bus Station
      0
      FlixBus
      Economy
      $88
    Travel time is 5h 5m longer, but you will save $24

Cheapest bus trips tomorrow

Prices are for one way and one person
  • FlixBus
    23h 20m
    0
    9:00 PM
    Rome
    Tiburtina Bus Station
    8:20 PM
    Prague
    Na Knížecí Station
    0
    FlixBus
    Economy
    $97
  • FlixBus
    20h 40m
    0
    9:00 PM
    Rome
    Tiburtina Bus Station
    5:40 PM
    Prague
    ÚAN Florenc
    0
    FlixBus
    Economy
    $97
  • FlixBus
    20h 30m
    0
    9:00 PM
    Rome
    Tiburtina Bus Station
    5:30 PM
    Prague
    Wilsonova Bus Station
    0
    FlixBus
    Economy
    $97
  • FlixBus
    26h 55m
    0
    9:00 PM
    Rome
    Tiburtina Bus Station
    11:55 PM
    Prague
    Wilsonova Bus Station
    0
    FlixBus
    Economy
    $98
  • FlixBus
    25h 15m
    0
    9:00 PM
    Rome
    Tiburtina Bus Station
    10:15 PM
    Prague
    Roztyly
    0
    FlixBus
    Economy
    $99

Cheapest bus trips Tuesday

Prices are for one way and one person
  • FlixBus
    20h 40m
    0
    9:00 PM
    Rome
    Tiburtina Bus Station
    5:40 PM
    Prague
    ÚAN Florenc
    0
    FlixBus
    Economy
    $86
  • FlixBus
    22h 55m
    0
    9:20 PM
    Rome
    Tiburtina Bus Station
    8:15 PM
    Prague
    ÚAN Florenc
    0
    FlixBus
    Economy
    $86
  • FlixBus
    25h 15m
    0
    9:00 PM
    Rome
    Tiburtina Bus Station
    10:15 PM
    Prague
    Roztyly
    0
    FlixBus
    Economy
    $86
  • FlixBus
    20h 30m
    0
    9:00 PM
    Rome
    Tiburtina Bus Station
    5:30 PM
    Prague
    Wilsonova Bus Station
    0
    FlixBus
    Economy
    $86
  • FlixBus
    26h 55m
    0
    9:00 PM
    Rome
    Tiburtina Bus Station
    11:55 PM
    Prague
    Wilsonova Bus Station
    0
    FlixBus
    Economy
    $86

Cheapest bus trips Wednesday

Prices are for one way and one person
  • RegioJet
    20h 10m
    0
    1:00 PM
    Rome
    Tiburtina Bus Station
    9:10 AM
    Prague
    ÚAN Florenc
    0
    RegioJet
    Economy
    $83
  • FlixBus
    25h 15m
    0
    9:00 PM
    Rome
    Tiburtina Bus Station
    10:15 PM
    Prague
    Roztyly
    0
    FlixBus
    Economy
    $86
  • FlixBus
    26h 55m
    0
    9:00 PM
    Rome
    Tiburtina Bus Station
    11:55 PM
    Prague
    Wilsonova Bus Station
    0
    FlixBus
    Economy
    $86
  • FlixBus
    27h 0m
    0
    5:00 PM
    Rome
    Tiburtina Bus Station
    8:00 PM
    Prague
    Wilsonova Bus Station
    0
    FlixBus
    Economy
    $88
  • RegioJet
    20h 39m
    0
    1:00 PM
    Rome
    Tiburtina Bus Station
    9:39 AM
    Prague
    Wilsonova Bus Station
    0
    RegioJet
    Economy
    $97

Cheapest bus trips Thursday

Prices are for one way and one person
  • FlixBus
    20h 45m
    0
    5:05 PM
    Rome
    Tiburtina Bus Station
    1:50 PM
    Prague
    ÚAN Florenc
    0
    FlixBus
    Economy
    $91
  • FlixBus
    20h 35m
    0
    5:05 PM
    Rome
    Tiburtina Bus Station
    1:40 PM
    Prague
    Wilsonova Bus Station
    0
    FlixBus
    Economy
    $91
  • FlixBus
    25h 15m
    0
    9:00 PM
    Rome
    Tiburtina Bus Station
    10:15 PM
    Prague
    Roztyly
    0
    FlixBus
    Economy
    $93
  • FlixBus
    26h 55m
    0
    9:00 PM
    Rome
    Tiburtina Bus Station
    11:55 PM
    Prague
    Wilsonova Bus Station
    0
    FlixBus
    Economy
    $93
  • FlixBus
    20h 30m
    0
    5:25 PM
    Rome
    Anagnina Bus Station
    1:55 PM
    Prague
    Wilsonova Bus Station
    0
    FlixBus
    Economy
    $94

Cheapest bus trips Friday

Prices are for one way and one person
  • FlixBus
    23h 20m
    0
    9:00 PM
    Rome
    Tiburtina Bus Station
    8:20 PM
    Prague
    Na Knížecí Station
    0
    FlixBus
    Economy
    $97
  • FlixBus
    20h 40m
    0
    9:00 PM
    Rome
    Tiburtina Bus Station
    5:40 PM
    Prague
    ÚAN Florenc
    0
    FlixBus
    Economy
    $97
  • FlixBus
    20h 35m
    0
    10:55 PM
    Rome
    Tiburtina Bus Station
    7:30 PM
    Prague
    ÚAN Florenc
    0
    FlixBus
    Economy
    $97
  • FlixBus
    20h 30m
    0
    9:00 PM
    Rome
    Tiburtina Bus Station
    5:30 PM
    Prague
    Wilsonova Bus Station
    0
    FlixBus
    Economy
    $97
  • FlixBus
    20h 25m
    0
    10:55 PM
    Rome
    Tiburtina Bus Station
    7:20 PM
    Prague
    Wilsonova Bus Station
    0
    FlixBus
    Economy
    $97

Cheapest bus trips Saturday

Prices are for one way and one person
  • FlixBus
    20h 45m
    0
    9:30 AM
    Rome
    Tiburtina Bus Station
    6:15 AM
    Prague
    ÚAN Florenc
    0
    FlixBus
    Economy
    $104
  • FlixBus
    24h 45m
    0
    7:30 AM
    Rome
    Anagnina Bus Station
    8:15 AM
    Prague
    Roztyly
    0
    FlixBus
    Economy
    $104
  • FlixBus
    21h 30m
    0
    1:05 PM
    Rome
    Anagnina Bus Station
    10:35 AM
    Prague
    Wilsonova Bus Station
    0
    FlixBus
    Economy
    $104
  • FlixBus
    20h 20m
    0
    1:05 PM
    Rome
    Anagnina Bus Station
    9:25 AM
    Prague
    ÚAN Florenc
    0
    FlixBus
    Economy
    $104
  • FlixBus
    20h 30m
    0
    9:30 AM
    Rome
    Tiburtina Bus Station
    6:00 AM
    Prague
    Wilsonova Bus Station
    0
    FlixBus
    Economy
    $104

Frequency of bus connections between Rome and Prague

See here how frequent the connections between Rome and Prague are, during different times and days of the week.
Saturday is the busiest day, with more than 48 daily buses from Rome to Prague. Tuesday has instead the fewest connections, with only 40 daily coaches between Rome and Prague.
The busiest time of the day is the Afternoon, with 142 buses from Rome to Prague, while Night sees the fewest connections between Rome and Prague, with 4 offers.

Facts about the bus from Rome to Prague

Compare all providers like FlixBus and RegioJet that travel 43 times every day by bus from Rome to Prague in one click! Book your bus ticket from Rome to Prague starting from $83!

Cheapest Bus $83
Fastest Bus 20h 10m
Earliest Bus 1:40 AM
Latest Bus 11:35 PM
Daily Bus Routes 43 Ø
Distance 572.5 miles
Bus Companies FlixBus and RegioJet

Cheapest bus connections from Rome to Prague

Every day, 43 buses from 2 bus companies leave Rome for Prague: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 06/22/2025 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 06/22
$130
Monday 06/23
$97
Tuesday 06/24
$86
Wednesday 06/25
$86
Thursday 06/26
$91
Friday 06/27
$97
Saturday 06/28
$104
Sunday 06/29
$92
Monday 06/30
$101
Tuesday 07/01
$90
Wednesday 07/02
$88
Thursday 07/03
$97
Friday 07/04
$93
Saturday 07/05
$91
Sunday 07/06
$103
Monday 07/07
$83
Tuesday 07/08
$84
Wednesday 07/09
$82
Thursday 07/10
$85
Friday 07/11
$103
Saturday 07/12
$105
Sunday 07/13
$108
Monday 07/14
$90
Tuesday 07/15
$81
Wednesday 07/16
$82
Thursday 07/17
$87
Friday 07/18
$109
Saturday 07/19

The cheapest time to travel from Rome to Prague

See here on which day and which time of the day you can find the cheapest bus ticket from Rome to Prague, for the next 30 days.
With a price starting from $83, Wednesday is the cheapest day for a bus from Rome to Prague. Sunday instead is the most expensive day with prices starting from $130.
Afternoon is the cheapest day time for bus tickets from Rome to Prague, with $83. Night is the most expensive time of the day with prices starting from $129.

How to save money travelling from Rome to Prague

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Rome to Prague in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Rome to Prague, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Rome to Prague are also emptier.

Beloved bus companies from Rome to Prague

These are the most booked bus companies between Rome to Prague from our users.

RegioJet from Rome to Prague

RegioJet

Here you will find the key facts about the RegioJet bus route Rome to Prague:

Cheapest Price $83
Fastest Bus 20h 10m
Earliest Bus 1:00 PM
Last Bus 1:00 PM
Daily Connections 2 Ø
Found on 6/16/2025

All bus stations and stops in Rome and Prague

In the map below, you can see where to find all bus stations in Rome and Prague.

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Rome to Prague? Compare all modes of transports from Rome to Prague.

Service and Comfort on the bus from Rome to Prague

Want to know which seat classes are available on the buses from Rome to Prague? Or which bus companies serve the route Rome to Prague? Below you will find answers to your questions.

FAQs about the Rome to Prague bus

How much does a Rome Prague bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $83 and takes 20h 10m to reach Prague. Compare offers to save money!

How much could I save by comparing buses from Rome to Prague?

This route is offered by 2 companies with a range of ticket prices between $83 and $224. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Prague.

On average, how many connections are available from Rome to Prague each day?

Every day, the Rome to Prague bus route is served by approximately 43 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Rome to Prague take?

The fastest bus from Rome to Prague is offered by RegioJet and takes 20h 10m. Bus tickets for this connection cost $83. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Rome to Prague?

The earliest bus arriving in Prague from Rome starts at 1:40 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Rome to Prague?

The latest bus trip departing from Rome for Prague starts at 11:35 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Rome Prague route?

When traveling by bus from Rome to Prague, passengers can travel with FlixBus and RegioJet. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Rome and Prague?

You can check all the direct connections between Rome and Prague by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and RegioJet.

What can I take with me on the Rome to Prague bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Rome Prague bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Rome Prague bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Rome to Prague on your planned travel date.

Available seat classes which are offered on the bus route Rome to Prague

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Rome and to Prague

Here’s an overview of the most popular bus routes to Rome and to Prague. Simply click on the connection of your choice, and you will find all the details about your bus route!
Bus from Amalfi to Rome Bus from Amalfi to Rome
From Assisi to Rome bus From Assisi to Rome bus
Bus Milan - Rome Bus Milan - Rome
Bus to Rome from Pisa Bus to Rome from Pisa
Milan to Prague bus Milan to Prague bus
Buses from Istanbul to Prague Buses from Istanbul to Prague
Buses Budapest - Prague Buses Budapest - Prague
Bus Vienna to Prague Bus Vienna to Prague
Popular Airport Shuttles to Rome and to Prague
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