Bus from Rome to Prague from $68

Compare all the bus companies and find the best price with CheckMyBus
Compare & Save Millions of buses in one click. Save up to 70%!
The Best Deals Save up to 70%
The Most Choices Millions of routes worldwide
Easy and Transparent Compare offers with 1 click

Compare all timetables for the bus from Rome to Prague

Here is a selection of the cheapest bus trips from the schedule from Rome to Prague from various bus operators like FlixBus or RegioJet for the next days.

today
$124
tomorrow
$105
Friday
$118
Saturday
$131
Sunday
$129
Monday
$136
Tuesday
$84

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 26h 10m 5:00 PM Rome Tiburtina Bus Station 7:10 PM Prague Na Knížecí Station  Economy $124
FlixBus 22h 45m 5:25 PM Rome Anagnina Bus Station 4:10 PM Prague Černý Most  Economy $124
FlixBus 25h 45m 5:25 PM Rome Anagnina Bus Station 7:10 PM Prague Na Knížecí Station  Economy $124
FlixBus 27h 0m 5:00 PM Rome Tiburtina Bus Station 8:00 PM Prague Wilsonova Bus Station  Economy $125
FlixBus 20h 30m 9:00 PM Rome Tiburtina Bus Station 5:30 PM Prague Wilsonova Bus Station  Economy $125

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 25h 10m 12:20 PM Rome Tiburtina Bus Station 1:30 PM Prague Roztyly  Economy $105
FlixBus 20h 45m 9:30 AM Rome Tiburtina Bus Station 6:15 AM Prague ÚAN Florenc  Economy $105
FlixBus 20h 30m 9:30 AM Rome Tiburtina Bus Station 6:00 AM Prague Wilsonova Bus Station  Economy $105
FlixBus 23h 5m 1:05 PM Rome Anagnina Bus Station 12:10 PM Prague Wilsonova Bus Station  Economy $105
FlixBus 20h 20m 1:05 PM Rome Anagnina Bus Station 9:25 AM Prague ÚAN Florenc  Economy $105

Cheapest bus trips Friday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 20h 30m 9:00 PM Rome Tiburtina Bus Station 5:30 PM Prague Wilsonova Bus Station  Economy $118
FlixBus 20h 45m 9:00 PM Rome Tiburtina Bus Station 5:45 PM Prague ÚAN Florenc  Economy $118
FlixBus 23h 20m 9:00 PM Rome Tiburtina Bus Station 8:20 PM Prague Na Knížecí Station  Economy $118
FlixBus 20h 20m 1:05 PM Rome Anagnina Bus Station 9:25 AM Prague ÚAN Florenc  Economy $131
FlixBus 24h 25m 1:05 PM Rome Anagnina Bus Station 1:30 PM Prague Roztyly  Economy $131

Cheapest bus trips Saturday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 22h 15m 11:05 PM Rome Tiburtina Bus Station 9:20 PM Prague ÚAN Florenc  Economy $131
FlixBus 24h 25m 1:05 PM Rome Anagnina Bus Station 1:30 PM Prague Roztyly  Economy $131
FlixBus 20h 20m 1:05 PM Rome Anagnina Bus Station 9:25 AM Prague ÚAN Florenc  Economy $131
FlixBus 22h 50m 11:05 PM Rome Tiburtina Bus Station 9:55 PM Prague Černý Most  Economy $131
FlixBus 20h 30m 9:00 PM Rome Tiburtina Bus Station 5:30 PM Prague Wilsonova Bus Station  Economy $132
  • Did you know that if you travel from Rome to Prague via Udine, you can save more than $18? You can find the corresponding connections below.
    • FlixBus
      24h 55m
      0
      12:45 PM
      Rome
      Anagnina Bus Station
      11:40 PM
      Udine
      Train Station
      0
      FlixBus
      Economy
      $33
      • Waiting Time 2h 45m
    • FlixBus
      11h 15m
      0
      2:25 AM
      Udine
      Train Station
      1:40 PM
      Prague
      Wilsonova Bus Station
      0
      FlixBus
      Economy
      $80
    Travel time is 4h 35m longer, but you will save $18

Cheapest bus trips Sunday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 20h 35m 5:05 PM Rome Tiburtina Bus Station 1:40 PM Prague Wilsonova Bus Station  Economy $129
FlixBus 20h 45m 5:05 PM Rome Tiburtina Bus Station 1:50 PM Prague ÚAN Florenc  Economy $129
FlixBus 28h 5m 10:55 PM Rome Tiburtina Bus Station 3:00 AM Prague Wilsonova Bus Station  Economy $149
FlixBus 20h 30m 9:00 PM Rome Tiburtina Bus Station 5:30 PM Prague Wilsonova Bus Station  Economy $150
FlixBus 20h 45m 9:00 PM Rome Tiburtina Bus Station 5:45 PM Prague ÚAN Florenc  Economy $150
  • Did you know that if you travel from Rome to Prague via Udine, you can save more than $16? You can find the corresponding connections below.
    • FlixBus
      24h 55m
      0
      12:45 PM
      Rome
      Anagnina Bus Station
      11:40 PM
      Udine
      Train Station
      0
      FlixBus
      Economy
      $33
      • Waiting Time 2h 45m
    • FlixBus
      11h 15m
      0
      2:25 AM
      Udine
      Train Station
      1:40 PM
      Prague
      Wilsonova Bus Station
      0
      FlixBus
      Economy
      $80
    Travel time is 4h 25m longer, but you will save $16

Cheapest bus trips Monday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 23h 20m 9:00 PM Rome Tiburtina Bus Station 8:20 PM Prague Na Knížecí Station  Economy $136
FlixBus 20h 30m 9:30 AM Rome Tiburtina Bus Station 6:00 AM Prague Wilsonova Bus Station  Economy $137
FlixBus 20h 30m 9:00 PM Rome Tiburtina Bus Station 5:30 PM Prague Wilsonova Bus Station  Economy $137
FlixBus 20h 45m 9:30 AM Rome Tiburtina Bus Station 6:15 AM Prague ÚAN Florenc  Economy $137
FlixBus 20h 45m 9:00 PM Rome Tiburtina Bus Station 5:45 PM Prague ÚAN Florenc  Economy $137
  • Did you know that if you travel from Rome to Prague via Udine, you can save more than $23? You can find the corresponding connections below.
    • FlixBus
      24h 55m
      0
      12:45 PM
      Rome
      Anagnina Bus Station
      11:40 PM
      Udine
      Train Station
      0
      FlixBus
      Economy
      $33
      • Waiting Time 2h 45m
    • FlixBus
      11h 15m
      0
      2:25 AM
      Udine
      Train Station
      1:40 PM
      Prague
      Wilsonova Bus Station
      0
      FlixBus
      Economy
      $80
    Travel time is 4h 25m longer, but you will save $23

Cheapest bus trips Tuesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
RegioJet 20h 10m 1:00 PM Rome Tiburtina Bus Station 9:10 AM Prague ÚAN Florenc  Economy $84
RegioJet 20h 58m 1:00 PM Rome Tiburtina Bus Station 9:58 AM Prague Wilsonova Bus Station  Economy $94
FlixBus 20h 30m 9:00 PM Rome Tiburtina Bus Station 5:30 PM Prague Wilsonova Bus Station  Economy $125
FlixBus 20h 45m 9:00 PM Rome Tiburtina Bus Station 5:45 PM Prague ÚAN Florenc  Economy $125
FlixBus 23h 40m 10:15 AM Rome Tiburtina Bus Station 9:55 AM Prague Na Knížecí Station  Economy $125

Best Price Offer: The price for the cheapest bus from Rome to Prague is $68 on 1/9/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Rome and Prague

See here how frequent the connections between Rome and Prague are, during different times and days of the week.
Tuesday is the busiest day, with more than 47 daily buses from Rome to Prague. Wednesday has instead the fewest connections, with only 29 daily coaches between Rome and Prague.
The busiest time of the day is the Afternoon, with 139 buses from Rome to Prague, while Night sees the fewest connections between Rome and Prague, with 5 offers.

Facts about the bus from Rome to Prague

Compare all providers like FlixBus and RegioJet that travel 41 times every day by bus from Rome to Prague in one click! Book your bus ticket from Rome to Prague starting from $68!

Cheapest Bus $68
Fastest Bus 20h 10m
Earliest Bus 9:30 AM
Latest Bus 11:05 PM
Daily Bus Routes 41 Ø
Distance 572.5 miles
Bus Companies FlixBus and RegioJet

Cheapest bus connections from Rome to Prague

Every day, 41 buses from 2 bus companies leave Rome for Prague: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/17/2025 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 12/14
Monday 12/15
Tuesday 12/16
Wednesday 12/17
$124
Thursday 12/18
$105
Friday 12/19
$118
Saturday 12/20
$131
Sunday 12/21
$129
Monday 12/22
$137
Tuesday 12/23
$125
Wednesday 12/24
$121
Thursday 12/25
$137
Friday 12/26
$141
Saturday 12/27
$145
Sunday 12/28
$145
Monday 12/29
$139
Tuesday 12/30
$129
Wednesday 12/31
$110
Thursday 01/01
$158
Friday 01/02
$139
Saturday 01/03
$138
Sunday 01/04
$117
Monday 01/05
$89
Tuesday 01/06
$98
Wednesday 01/07
$90
Thursday 01/08
$77
Friday 01/09
$68
Saturday 01/10

The cheapest time to travel from Rome to Prague

See here on which day and which time of the day you can find the cheapest bus ticket from Rome to Prague, for the next 30 days.
With a price starting from $60, Monday is the cheapest day for a bus from Rome to Prague. Wednesday instead is the most expensive day with prices starting from $90.
Night is the cheapest day time for bus tickets from Rome to Prague, with $60. Evening is the most expensive time of the day with prices starting from $109.

How to save money travelling from Rome to Prague

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Rome to Prague in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Rome to Prague, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Rome to Prague are also emptier.

Beloved bus companies from Rome to Prague

These are the most booked bus companies between Rome to Prague from our users.

RegioJet from Rome to Prague

RegioJet

Here you will find the key facts about the RegioJet bus route Rome to Prague:

Cheapest Price $84
Fastest Bus 20h 10m
Earliest Bus 1:00 PM
Last Bus 1:00 PM
Daily Connections 2 Ø
Found on 12/14/2025

All bus stations and stops in Rome and Prague

In the map below, you can see where to find all bus stations in Rome and Prague.

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Rome to Prague? Compare all modes of transports from Rome to Prague.

Service and Comfort on the bus from Rome to Prague

Want to know which seat classes are available on the buses from Rome to Prague? Or which bus companies serve the route Rome to Prague? Below you will find answers to your questions.

FAQs about the Rome to Prague bus

How much does a Rome Prague bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $68 and takes 20h 10m to reach Prague. Compare offers to save money!

How much could I save by comparing buses from Rome to Prague?

This route is offered by 2 companies with a range of ticket prices between $68 and $234. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Prague.

On average, how many connections are available from Rome to Prague each day?

Every day, the Rome to Prague bus route is served by approximately 41 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Rome to Prague take?

The fastest bus from Rome to Prague is offered by RegioJet and takes 20h 10m. Bus tickets for this connection cost $84. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Rome to Prague?

The earliest bus arriving in Prague from Rome starts at 9:30 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Rome to Prague?

The latest bus trip departing from Rome for Prague starts at 11:05 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Rome Prague route?

When traveling by bus from Rome to Prague, passengers can travel with FlixBus and RegioJet. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Rome and Prague?

You can check all the direct connections between Rome and Prague by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and RegioJet.

What can I take with me on the Rome to Prague bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Rome Prague bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Rome Prague bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Rome to Prague on your planned travel date.

How does CheckMyBus find the best bus deals from Rome to Prague?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 41 daily trips between Rome and Prague. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Rome to Prague?

Prices and availability for 41 trips between Rome and Prague change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Rome to Prague

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Rome and to Prague

Here’s an overview of the most popular bus routes to Rome and to Prague. Simply click on the connection of your choice, and you will find all the details about your bus route!
Bus Bologna to Rome Bus Bologna to Rome
Buses Zurich - Rome Buses Zurich - Rome
Buses Bari - Rome Buses Bari - Rome
Bus from Barcelona to Rome Bus from Barcelona to Rome
Bus to Prague from Brno Bus to Prague from Brno
Krakow to Prague bus Krakow to Prague bus
Bus to Prague from Paris Bus to Prague from Paris
Buses Warsaw to Prague Buses Warsaw to Prague
Popular Airport Shuttles to Rome and to Prague
CheckMyBus › Buses in Italy › Bus to Rome › Bus to Prague

The CheckMyBus App

Free Download

App Store
CheckMyBus App
Close
GPDR CheckMyBus shield

We value your privacy!

To

show

you

the

best

bus

offers,

we

and

our

partners

use

technical,

analytical,

and

marketing

cookies

to

personalize

the

ads.

We

remember

your

anonymized

details

to

provide

a

personalized

experience.