Which bus from Lyon to Prague is the cheapest?

Compare all bus companies and find the best price: Bus tickets from $56
The Best Deals Save up to 70%
The Most Choices Millions of routes worldwide
Easy and Transparent Compare offers with 1 click

Compare all timetables for the bus from Lyon to Prague

Here is a selection of the cheapest bus trips from the schedule from Lyon to Prague from various bus operators like FlixBus or RegioJet for the next days.

today
tomorrow
Wednesday
$62
Thursday
Friday
Saturday
$71
Sunday

Cheapest bus trips Wednesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 20h 30m 2:25 AM Lyon Perrache Bus Stop 10:55 PM Prague Na Knížecí Station  Economy $62
FlixBus 19h 55m 2:25 AM Lyon Perrache Bus Stop 10:20 PM Prague ÚAN Florenc  Economy $62
FlixBus 24h 35m 2:25 AM Lyon Perrache Bus Stop 3:00 AM Prague Wilsonova Bus Station  Economy $62

Cheapest bus trips Saturday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
RegioJet 15h 50m 2:35 PM Lyon Perrache Bus Stop 6:25 AM Prague Train station Wilsonova  Economy $71
RegioJet 15h 55m 2:35 PM Lyon Perrache Bus Stop 6:30 AM Prague ÚAN Florenc  Economy $71

Best Price Offer: The price for the cheapest bus from Lyon to Prague is $56 on 2/2/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Lyon and Prague

See here how frequent the connections between Lyon and Prague are, during different times and days of the week.
Wednesday is the busiest day, with more than 3 daily buses from Lyon to Prague. Saturday has instead the fewest connections, with only 2 daily coaches between Lyon and Prague.
The busiest time of the day is the Night, with 3 buses from Lyon to Prague, while Afternoon sees the fewest connections between Lyon and Prague, with 2 offers.

Facts about the bus from Lyon to Prague

Compare all providers like FlixBus and RegioJet that travel 2 times every day by bus from Lyon to Prague in one click! Book your bus ticket from Lyon to Prague starting from $56!

Cheapest Bus $56
Fastest Bus 15h 50m
Earliest Bus 2:25 AM
Latest Bus 2:35 PM
Daily Bus Routes 2 Ø
Distance 535.0 miles
Bus Companies FlixBus and RegioJet

Cheapest bus connections from Lyon to Prague

Every day, 2 buses from 2 bus companies leave Lyon for Prague: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 01/26/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 01/25
Monday 01/26
$70
Tuesday 01/27
$65
Wednesday 01/28
$62
Thursday 01/29
$65
Friday 01/30
$74
Saturday 01/31
$69
Sunday 02/01
$69
Monday 02/02
$56
Tuesday 02/03
$60
Wednesday 02/04
$63
Thursday 02/05
$68
Friday 02/06
$72
Saturday 02/07
$70
Sunday 02/08
$70
Monday 02/09
$60
Tuesday 02/10
$62
Wednesday 02/11
$62
Thursday 02/12
$62
Friday 02/13
$72
Saturday 02/14
$70
Sunday 02/15
$72
Monday 02/16
$60
Tuesday 02/17
$57
Wednesday 02/18
$59
Thursday 02/19
$58
Friday 02/20
$68
Saturday 02/21

The cheapest time to travel from Lyon to Prague

See here on which day and which time of the day you can find the cheapest bus ticket from Lyon to Prague, for the next 30 days.
With a price starting from $59, Wednesday is the cheapest day for a bus from Lyon to Prague. Saturday instead is the most expensive day with prices starting from $69.
Night is the cheapest day time for bus tickets from Lyon to Prague, with $56. Afternoon is the most expensive time of the day with prices starting from $70.

How to save money travelling from Lyon to Prague

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Lyon to Prague in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Lyon to Prague, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Lyon to Prague are also emptier.

Beloved bus companies from Lyon to Prague

These are the most booked bus companies between Lyon to Prague from our users.

FlixBus from Lyon to Prague

FlixBus

Here you will find the key facts about the FlixBus bus route Lyon to Prague:

Cheapest Price $62
Fastest Bus 19h 55m
Earliest Bus 2:25 AM
Last Bus 2:25 AM
Daily Connections 3 Ø
Found on 1/12/2026

Latest reviews for bus companies on the route Lyon - Prague

FlixBus
Théo, 11/20/2025
On débute avec 2h50 de retard cumulé à mi-chemin pour le premier car FlixBus… Correspondance du second car bien évidemment manquée, toujours avec FlixBus… Dernier transport de la journée… dommage! O ... On débute avec 2h50 de retard cumulé à mi-chemin pour le premier car FlixBus… Correspondance du second car bien évidemment manquée, toujours avec FlixBus… Dernier transport de la journée… dommage! On repassera le matin suivant… S'il nous est pas encore passé l'envie d'arriver à destination… Toujours en suppléments à ses frais… s'il vous plaît bien sûr! Certains apprécieraient peut-être ce type d'aventure surprise… À se retrouver paumé au beau milieu de la nuit à 500km de chez soi… À moitié assommé d'une première étape de trajet complètement hasardeuse… Lâché dans une ville inconnue depuis un car douteux approchant les 3h du matin. Résultat miraculeux : Finalement arrivé à destination… à l'état de zombie certes… mais bien arrivé… Et sûrement pas grâce à cette enseigne… pour le fait de réagir face à la situation… Et débarquer 26h49 après l'horaire de départ contre les 9h44 initialement prévues… Le tout triplant les coûts non reconnus du voyage "low cost"… On dit merci qui ?
FlixBus
Pat, 8/21/2024

Najbardziej słabe jest robienie zdjęć pasażerom..Czy chcecie zeby ktos z pasażerow został zamordowany... Akurat to jest przestepstwo...

All bus stations and stops in Lyon and Prague

In the map below, you can see where to find all bus stations in Lyon and Prague.

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Lyon to Prague? Compare all modes of transports from Lyon to Prague.

Service and Comfort on the bus from Lyon to Prague

Want to know which seat classes are available on the buses from Lyon to Prague? Or which bus companies serve the route Lyon to Prague? Below you will find answers to your questions.

FAQs about the Lyon to Prague bus

How much does a Lyon Prague bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $56 and takes 20h 30m to reach Prague. Compare offers to save money!

How much could I save by comparing buses from Lyon to Prague?

This route is offered by 2 companies with a range of ticket prices between $56 and $71. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Prague.

On average, how many connections are available from Lyon to Prague each day?

Every day, the Lyon to Prague bus route is served by approximately 2 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Lyon to Prague take?

The fastest bus from Lyon to Prague is offered by RegioJet and takes 15h 50m. Bus tickets for this connection cost $71. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Lyon to Prague?

The earliest bus arriving in Prague from Lyon starts at 2:25 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Lyon to Prague?

The latest bus trip departing from Lyon for Prague starts at 2:35 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Lyon Prague route?

When traveling by bus from Lyon to Prague, passengers can travel with FlixBus and RegioJet. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Lyon and Prague?

You can check all the direct connections between Lyon and Prague by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and RegioJet.

What can I take with me on the Lyon to Prague bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Lyon Prague bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Lyon Prague bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Lyon to Prague on your planned travel date.

How does CheckMyBus find the best bus deals from Lyon to Prague?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 2 daily trips between Lyon and Prague. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Lyon to Prague?

Prices and availability for 2 trips between Lyon and Prague change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Lyon to Prague

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Lyon and to Prague

Here’s an overview of the most popular bus routes to Lyon and to Prague. Simply click on the connection of your choice, and you will find all the details about your bus route!
Bus Poitiers to Lyon Bus Poitiers to Lyon
Bus to Lyon from Val-d'Isère Bus to Lyon from Val-d'Isère
Buses from Tignes to Lyon Buses from Tignes to Lyon
Bus Geneva to Lyon Bus Geneva to Lyon
Karlovy Vary to Prague bus Karlovy Vary to Prague bus
Bus to Prague from Copenhagen Bus to Prague from Copenhagen
From Cologne to Prague bus From Cologne to Prague bus
Buses Minsk to Prague Buses Minsk to Prague
Popular Airport Shuttles to Lyon and to Prague
CheckMyBus › Buses in France › Bus to Lyon › Bus to Prague

The CheckMyBus App

Free Download

App Store
CheckMyBus App
Close
GPDR CheckMyBus shield

We value your privacy!

To

show

you

the

best

bus

offers,

we

and

our

partners

use

technical,

analytical,

and

marketing

cookies

to

personalize

the

ads.

We

remember

your

anonymized

details

to

provide

a

personalized

experience.