Bus from Rome to Lyon from $52

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Compare all timetables for the bus from Rome to Lyon

Here is a selection of the cheapest bus trips from the schedule from Rome to Lyon from various bus operators like FlixBus, Itabus or BlaBlaCar Bus for the next days.
today
from $58
tomorrow
from $52
Tuesday
from $52
Wednesday
from $52
Thursday
from $52
Friday
from $54
Saturday
from $54

Cheapest bus trips today

Prices are for one way and one person
  • Itabus
    14h 30m
    0
    7:00 AM
    Rome
    Tiburtina Bus Station
    9:30 PM
    Lyon
    Perrache Bus Stop
    0
    Itabus
    Premium Economy
    $58
  • Itabus
    14h 30m
    0
    7:00 AM
    Rome
    Tiburtina Bus Station
    9:30 PM
    Lyon
    Perrache Bus Stop
    0
    Itabus
    Premium Economy
    $64
  • FlixBus
    14h 55m
    0
    7:45 AM
    Rome
    Tiburtina Bus Station
    10:40 PM
    Lyon
    Perrache Bus Stop
    0
    FlixBus
    Economy
    $65
  • Itabus
    14h 30m
    0
    7:00 AM
    Rome
    Tiburtina Bus Station
    9:30 PM
    Lyon
    Perrache Bus Stop
    0
    Itabus
    Economy
    $73
  • FlixBus
    15h 20m
    0
    5:25 PM
    Rome
    Anagnina Bus Station
    8:45 AM
    Lyon
    Perrache Bus Stop
    0
    FlixBus
    Economy
    $82

Cheapest bus trips tomorrow

Prices are for one way and one person
  • Itabus
    14h 30m
    0
    7:00 AM
    Rome
    Tiburtina Bus Station
    9:30 PM
    Lyon
    Perrache Bus Stop
    0
    Itabus
    Premium Economy
    $52
  • Itabus
    14h 30m
    0
    7:00 AM
    Rome
    Tiburtina Bus Station
    9:30 PM
    Lyon
    Perrache Bus Stop
    0
    Itabus
    Premium Economy
    $58
  • BlaBlaCar Bus
    14h 50m
    0
    3:20 PM
    Rome
    Tiburtina Bus Station
    6:10 AM
    Lyon
    Perrache Bus Stop
    0
    BlaBlaCar Bus
    Economy
    $61
  • FlixBus
    14h 55m
    0
    7:45 AM
    Rome
    Tiburtina Bus Station
    10:40 PM
    Lyon
    Perrache Bus Stop
    0
    FlixBus
    Economy
    $62
  • FlixBus
    15h 20m
    0
    5:25 PM
    Rome
    Anagnina Bus Station
    8:45 AM
    Lyon
    Perrache Bus Stop
    0
    FlixBus
    Economy
    $65
  • Did you know that if you travel from Rome to Lyon via Grenoble, you can save more than $5? You can find the corresponding connections below.
    • FlixBus
      21h 30m
      0
      10:15 AM
      Rome
      Tiburtina Bus Station
      11:45 PM
      Grenoble
      Bus Station
      0
      FlixBus
      Economy
      $39
      • Waiting Time 6h 30m
    • FlixBus
      1h 30m
      0
      6:15 AM
      Grenoble
      Bus Station
      7:45 AM
      Lyon
      Perrache Bus Stop
      0
      FlixBus
      Economy
      $8
    Travel time is 7h 0m longer, but you will save $5

Cheapest bus trips Tuesday

Prices are for one way and one person
  • Itabus
    14h 30m
    0
    7:00 AM
    Rome
    Tiburtina Bus Station
    9:30 PM
    Lyon
    Perrache Bus Stop
    0
    Itabus
    Premium Economy
    $52
  • Itabus
    15h 10m
    0
    9:45 PM
    Rome
    Tiburtina Bus Station
    12:55 PM
    Lyon
    Perrache Bus Stop
    0
    Itabus
    Premium Economy
    $52
  • Itabus
    14h 30m
    0
    7:00 AM
    Rome
    Tiburtina Bus Station
    9:30 PM
    Lyon
    Perrache Bus Stop
    0
    Itabus
    Premium Economy
    $58
  • FlixBus
    14h 55m
    0
    8:50 AM
    Rome
    Tiburtina Bus Station
    11:45 PM
    Lyon
    Perrache Bus Stop
    0
    FlixBus
    Economy
    $68
  • FlixBus
    15h 20m
    0
    5:25 PM
    Rome
    Anagnina Bus Station
    8:45 AM
    Lyon
    Perrache Bus Stop
    0
    FlixBus
    Economy
    $76
  • Did you know that if you travel from Rome to Lyon via Grenoble, you can save more than $5? You can find the corresponding connections below.
    • FlixBus
      20h 30m
      0
      10:15 AM
      Rome
      Tiburtina Bus Station
      11:45 PM
      Grenoble
      Bus Station
      0
      FlixBus
      Economy
      $41
      • Waiting Time 5h 30m
    • BlaBlaCar Bus
      1h 30m
      0
      5:15 AM
      Grenoble
      Bus Station
      6:45 AM
      Lyon
      Perrache Train Station
      0
      BlaBlaCar Bus
      Economy
      $6
    Travel time is 6h 0m longer, but you will save $5

Cheapest bus trips Wednesday

Prices are for one way and one person
  • Itabus
    14h 30m
    0
    7:00 AM
    Rome
    Tiburtina Bus Station
    9:30 PM
    Lyon
    Perrache Bus Stop
    0
    Itabus
    Premium Economy
    $52
  • Itabus
    14h 30m
    0
    7:00 AM
    Rome
    Tiburtina Bus Station
    9:30 PM
    Lyon
    Perrache Bus Stop
    0
    Itabus
    Premium Economy
    $54
  • Itabus
    15h 10m
    0
    9:45 PM
    Rome
    Tiburtina Bus Station
    12:55 PM
    Lyon
    Perrache Bus Stop
    0
    Itabus
    Premium Economy
    $54
  • FlixBus
    15h 20m
    0
    5:25 PM
    Rome
    Anagnina Bus Station
    8:45 AM
    Lyon
    Perrache Bus Stop
    0
    FlixBus
    Economy
    $60
  • FlixBus
    14h 55m
    0
    8:50 AM
    Rome
    Tiburtina Bus Station
    11:45 PM
    Lyon
    Perrache Bus Stop
    0
    FlixBus
    Economy
    $62
  • Did you know that if you travel from Rome to Lyon via Grenoble, you can save more than $5? You can find the corresponding connections below.
    • FlixBus
      20h 30m
      0
      10:15 AM
      Rome
      Tiburtina Bus Station
      11:45 PM
      Grenoble
      Bus Station
      0
      FlixBus
      Economy
      $41
      • Waiting Time 5h 30m
    • BlaBlaCar Bus
      1h 30m
      0
      5:15 AM
      Grenoble
      Bus Station
      6:45 AM
      Lyon
      Perrache Train Station
      0
      BlaBlaCar Bus
      Economy
      $6
    Travel time is 6h 0m longer, but you will save $5

Cheapest bus trips Thursday

Prices are for one way and one person
  • Itabus
    14h 30m
    0
    7:00 AM
    Rome
    Tiburtina Bus Station
    9:30 PM
    Lyon
    Perrache Bus Stop
    0
    Itabus
    Premium Economy
    $52
  • Itabus
    15h 10m
    0
    9:45 PM
    Rome
    Tiburtina Bus Station
    12:55 PM
    Lyon
    Perrache Bus Stop
    0
    Itabus
    Premium Economy
    $52
  • Itabus
    14h 30m
    0
    7:00 AM
    Rome
    Tiburtina Bus Station
    9:30 PM
    Lyon
    Perrache Bus Stop
    0
    Itabus
    Premium Economy
    $58
  • FlixBus
    14h 55m
    0
    7:45 AM
    Rome
    Tiburtina Bus Station
    10:40 PM
    Lyon
    Perrache Bus Stop
    0
    FlixBus
    Economy
    $59
  • FlixBus
    15h 20m
    0
    5:25 PM
    Rome
    Anagnina Bus Station
    8:45 AM
    Lyon
    Perrache Bus Stop
    0
    FlixBus
    Economy
    $60
  • Did you know that if you travel from Rome to Lyon via Grenoble, you can save more than $5? You can find the corresponding connections below.
    • FlixBus
      20h 30m
      0
      10:15 AM
      Rome
      Tiburtina Bus Station
      11:45 PM
      Grenoble
      Bus Station
      0
      FlixBus
      Economy
      $41
      • Waiting Time 5h 30m
    • BlaBlaCar Bus
      1h 30m
      0
      5:15 AM
      Grenoble
      Bus Station
      6:45 AM
      Lyon
      Perrache Train Station
      0
      BlaBlaCar Bus
      Economy
      $6
    Travel time is 6h 0m longer, but you will save $5

Cheapest bus trips Friday

Prices are for one way and one person
  • Itabus
    14h 30m
    0
    7:00 AM
    Rome
    Tiburtina Bus Station
    9:30 PM
    Lyon
    Perrache Bus Stop
    0
    Itabus
    Premium Economy
    $54
  • FlixBus
    15h 20m
    0
    5:25 PM
    Rome
    Anagnina Bus Station
    8:45 AM
    Lyon
    Perrache Bus Stop
    0
    FlixBus
    Economy
    $60
  • Itabus
    14h 30m
    0
    7:00 AM
    Rome
    Tiburtina Bus Station
    9:30 PM
    Lyon
    Perrache Bus Stop
    0
    Itabus
    Premium Economy
    $60
  • FlixBus
    14h 55m
    0
    7:45 AM
    Rome
    Tiburtina Bus Station
    10:40 PM
    Lyon
    Perrache Bus Stop
    0
    FlixBus
    Economy
    $62
  • Itabus
    15h 10m
    0
    9:45 PM
    Rome
    Tiburtina Bus Station
    12:55 PM
    Lyon
    Perrache Bus Stop
    0
    Itabus
    Premium Economy
    $63
  • Did you know that if you travel from Rome to Lyon via Grenoble, you can save more than $7? You can find the corresponding connections below.
    • FlixBus
      20h 30m
      0
      10:15 AM
      Rome
      Tiburtina Bus Station
      11:45 PM
      Grenoble
      Bus Station
      0
      FlixBus
      Economy
      $41
      • Waiting Time 5h 30m
    • BlaBlaCar Bus
      1h 30m
      0
      5:15 AM
      Grenoble
      Bus Station
      6:45 AM
      Lyon
      Perrache Train Station
      0
      BlaBlaCar Bus
      Economy
      $6
    Travel time is 6h 0m longer, but you will save $7

Cheapest bus trips Saturday

Prices are for one way and one person
  • Itabus
    15h 10m
    0
    9:45 PM
    Rome
    Tiburtina Bus Station
    12:55 PM
    Lyon
    Perrache Bus Stop
    0
    Itabus
    Premium Economy
    $54
  • Itabus
    14h 30m
    0
    7:00 AM
    Rome
    Tiburtina Bus Station
    9:30 PM
    Lyon
    Perrache Bus Stop
    0
    Itabus
    Premium Economy
    $58
  • Itabus
    14h 30m
    0
    7:00 AM
    Rome
    Tiburtina Bus Station
    9:30 PM
    Lyon
    Perrache Bus Stop
    0
    Itabus
    Premium Economy
    $58
  • FlixBus
    14h 55m
    0
    7:45 AM
    Rome
    Tiburtina Bus Station
    10:40 PM
    Lyon
    Perrache Bus Stop
    0
    FlixBus
    Economy
    $60
  • FlixBus
    15h 20m
    0
    5:25 PM
    Rome
    Anagnina Bus Station
    8:45 AM
    Lyon
    Perrache Bus Stop
    0
    FlixBus
    Economy
    $60
  • Did you know that if you travel from Rome to Lyon via Grenoble, you can save more than $7? You can find the corresponding connections below.
    • FlixBus
      20h 30m
      0
      10:15 AM
      Rome
      Tiburtina Bus Station
      11:45 PM
      Grenoble
      Bus Station
      0
      FlixBus
      Economy
      $41
      • Waiting Time 5h 30m
    • BlaBlaCar Bus
      1h 30m
      0
      5:15 AM
      Grenoble
      Bus Station
      6:45 AM
      Lyon
      Perrache Train Station
      0
      BlaBlaCar Bus
      Economy
      $6
    Travel time is 6h 0m longer, but you will save $7

Frequency of bus connections between Rome and Lyon

See here how frequent the connections between Rome and Lyon are, during different times and days of the week.
Saturday is the busiest day, with more than 21 daily buses from Rome to Lyon. Tuesday has instead the fewest connections, with only 16 daily coaches between Rome and Lyon.
The busiest time of the day is the Evening, with 59 buses from Rome to Lyon, while Night sees the fewest connections between Rome and Lyon, with 14 offers.

Facts about the bus from Rome to Lyon

Compare all providers like FlixBus, Itabus and BlaBlaCar Bus that travel 19 times every day by bus from Rome to Lyon in one click! Book your bus ticket from Rome to Lyon starting from $52!

Cheapest Bus $52
Fastest Bus 14h 30m
Earliest Bus 12:10 AM
Latest Bus 11:50 PM
Daily Bus Routes 19 Ø
Distance 465.5 miles
Bus Companies FlixBus, Itabus and BlaBlaCar Bus

Cheapest bus connections from Rome to Lyon

Every day, 19 buses from 3 bus companies leave Rome for Lyon: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 06/22/2025 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 06/22
$58
Monday 06/23
$58
Tuesday 06/24
$52
Wednesday 06/25
$60
Thursday 06/26
$59
Friday 06/27
$60
Saturday 06/28
$52
Sunday 06/29
$54
Monday 06/30
$54
Tuesday 07/01
$52
Wednesday 07/02
$52
Thursday 07/03
$52
Friday 07/04
$52
Saturday 07/05
$60
Sunday 07/06
$60
Monday 07/07
$63
Tuesday 07/08
$52
Wednesday 07/09
$46
Thursday 07/10
$46
Friday 07/11
$63
Saturday 07/12
$54
Sunday 07/13
$54
Monday 07/14
$66
Tuesday 07/15
$63
Wednesday 07/16
$46
Thursday 07/17
$52
Friday 07/18
$63
Saturday 07/19

The cheapest time to travel from Rome to Lyon

See here on which day and which time of the day you can find the cheapest bus ticket from Rome to Lyon, for the next 30 days.
With a price starting from $52, Tuesday is the cheapest day for a bus from Rome to Lyon. Sunday instead is the most expensive day with prices starting from $58.
Morning is the cheapest day time for bus tickets from Rome to Lyon, with $52. Night is the most expensive time of the day with prices starting from $68.

How to save money travelling from Rome to Lyon

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Rome to Lyon in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Rome to Lyon, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Rome to Lyon are also emptier.

All bus stations and stops in Rome and Lyon

In the map below, you can see where to find all bus stations in Rome and Lyon.

Service and Comfort on the bus from Rome to Lyon

Want to know which seat classes are available on the buses from Rome to Lyon? Or which bus companies serve the route Rome to Lyon? Below you will find answers to your questions.

FAQs about the Rome to Lyon bus

How much does a Rome Lyon bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $52 and takes 14h 30m to reach Lyon. Compare offers to save money!

How much could I save by comparing buses from Rome to Lyon?

This route is offered by 3 companies with a range of ticket prices between $52 and $154. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Lyon.

On average, how many connections are available from Rome to Lyon each day?

Every day, the Rome to Lyon bus route is served by approximately 19 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Rome to Lyon take?

The fastest bus from Rome to Lyon is offered by Itabus and takes 14h 30m. Bus tickets for this connection cost $58. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Rome to Lyon?

The earliest bus arriving in Lyon from Rome starts at 12:10 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Rome to Lyon?

The latest bus trip departing from Rome for Lyon starts at 11:50 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Rome Lyon route?

When traveling by bus from Rome to Lyon, passengers can travel with FlixBus, Itabus and BlaBlaCar Bus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Rome and Lyon?

You can check all the direct connections between Rome and Lyon by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus, Itabus and BlaBlaCar Bus.

What can I take with me on the Rome to Lyon bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Rome Lyon bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Rome Lyon bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Rome to Lyon on your planned travel date.

Available seat classes which are offered on the bus route Rome to Lyon

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

Premium Economy
PremiumEconomy

A mix between Economy and Business, it offers extra legroom, WI-FI and possible snacks.

More bus routes to Rome and to Lyon

Here’s an overview of the most popular bus routes to Rome and to Lyon. Simply click on the connection of your choice, and you will find all the details about your bus route!
Buses Verona - Rome Buses Verona - Rome
Bus to Rome from Lisbon Bus to Rome from Lisbon
Bus from Bologna to Rome Bus from Bologna to Rome
Bus Zurich - Rome Bus Zurich - Rome
Bus Annecy - Lyon Bus Annecy - Lyon
Buses London - Lyon Buses London - Lyon
Lisbon to Lyon bus Lisbon to Lyon bus
Bus from Nice to Lyon Bus from Nice to Lyon
Popular Airport Shuttles to Rome and to Lyon
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