What is the best way to travel from Lyon to Prague?
Looking for a trip? Compare all the available Flights and Buses for the journey to Prague from Lyon. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 4 available companies to find your perfect trip!
What is the cheapest way to reach Prague from Lyon?
You can get to Prague with just $60 by taking a Bus from FlixBus, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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FlixBus14h 50m06:05 PMLyonLyon Avenue Tony Garnier Bus Stop8:55 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/5/2026 6:05:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 11/6/2026 8:55:00 AM. 50 Economy ticket for $60 per person are available. Travel duration is 14h 50m
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FlixBus18h 10m010:00 PMLyonLyon Avenue Tony Garnier Bus Stop4:10 PMPragueČerný Most0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/5/2026 10:00:00 PM to Černý Most, Prague (Czech Republic) arriving at 11/6/2026 4:10:00 PM. 50 Economy ticket for $60 per person are available. Travel duration is 18h 10m
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FlixBus15h 15m06:05 PMLyonLyon Avenue Tony Garnier Bus Stop9:20 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/5/2026 6:05:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/6/2026 9:20:00 AM. 50 Economy ticket for $63 per person are available. Travel duration is 15h 15m
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FlixBus15h 55m05:00 PMLyons St. Exupery AirportLyons St. Exupery Airport8:55 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 11/5/2026 5:00:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 11/6/2026 8:55:00 AM. 50 Economy ticket for $74 per person are available. Travel duration is 15h 55m
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FlixBus16h 20m05:00 PMLyons St. Exupery AirportLyons St. Exupery Airport9:20 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 11/5/2026 5:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/6/2026 9:20:00 AM. 50 Economy ticket for $74 per person are available. Travel duration is 16h 20m
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Wizz Air23h 40m010:25 PMLyons St. Exupery AirportLyons St. Exupery Airport10:05 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Wizz Air goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 11/5/2026 10:25:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 11/6/2026 10:05:00 PM. 50 Economy ticket for $105 per person are available. Travel duration is 23h 40m
Cheapest Buses Thursday
Cheapest Flights Thursday
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FlixBus17h 25m010:00 PMLyonLyon Avenue Tony Garnier Bus Stop3:25 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/6/2026 10:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/7/2026 3:25:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 17h 25m
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FlixBus18h 10m010:00 PMLyonLyon Avenue Tony Garnier Bus Stop4:10 PMPragueČerný Most0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/6/2026 10:00:00 PM to Černý Most, Prague (Czech Republic) arriving at 11/7/2026 4:10:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 18h 10m
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BlaBlaCar Bus21h 45m012:00 PMLyonPerrache Train Station9:45 AMPragueÚAN Florenc0EconomyA Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 11/6/2026 12:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/7/2026 9:45:00 AM. 50 Economy ticket for $70 per person are available. Travel duration is 21h 45m
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STARSHIPPER SAS21h 55m04:40 PMLyons St. Exupery AirportLyons St. Exupery Airport2:35 PMPragueWilsonova Bus Station0EconomyA Bus from STARSHIPPER SAS goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 11/6/2026 4:40:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 11/7/2026 2:35:00 PM. 50 Economy ticket for $79 per person are available. Travel duration is 21h 55m
Cheapest Buses Friday
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FlixBus15h 15m06:05 PMLyonLyon Avenue Tony Garnier Bus Stop9:20 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/7/2026 6:05:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/8/2026 9:20:00 AM. 50 Economy ticket for $66 per person are available. Travel duration is 15h 15m
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FlixBus17h 5m09:30 PMLyonLyon Avenue Tony Garnier Bus Stop2:35 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/7/2026 9:30:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 11/8/2026 2:35:00 PM. 50 Economy ticket for $66 per person are available. Travel duration is 17h 5m
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FlixBus14h 50m06:05 PMLyonLyon Avenue Tony Garnier Bus Stop8:55 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/7/2026 6:05:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 11/8/2026 8:55:00 AM. 50 Economy ticket for $66 per person are available. Travel duration is 14h 50m
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FlixBus17h 15m09:30 PMLyonLyon Avenue Tony Garnier Bus Stop2:45 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/7/2026 9:30:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/8/2026 2:45:00 PM. 50 Economy ticket for $66 per person are available. Travel duration is 17h 15m
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Wizz Air17h 25m011:15 PMLyons St. Exupery AirportLyons St. Exupery Airport4:40 PMPrague AirportPrague Airport0EconomyA Flight from Wizz Air goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 11/7/2026 11:15:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 11/8/2026 4:40:00 PM. 50 Economy ticket for $107 per person are available. Travel duration is 17h 25m
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Vueling Airlines21h 35m07:15 PMLyons St. Exupery AirportLyons St. Exupery Airport4:50 PMPrague AirportPrague Airport0EconomyA Flight from Vueling Airlines goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 11/7/2026 7:15:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 11/8/2026 4:50:00 PM. 50 Economy ticket for $211 per person are available. Travel duration is 21h 35m
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Iberia21h 35m07:15 PMLyons St. Exupery AirportLyons St. Exupery Airport4:50 PMPrague AirportPrague Airport0EconomyA Flight from Iberia goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 11/7/2026 7:15:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 11/8/2026 4:50:00 PM. 50 Economy ticket for $212 per person are available. Travel duration is 21h 35m
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AJet21h 20m02:45 PMLyons St. Exupery AirportLyons St. Exupery Airport12:05 PMPrague AirportPrague Airport0EconomyA Flight from AJet goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 11/7/2026 2:45:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 11/8/2026 12:05:00 PM. 50 Economy ticket for $257 per person are available. Travel duration is 21h 20m
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Transavia France9h 35m011:25 AMLyons St. Exupery AirportLyons St. Exupery Airport9:00 PMPrague AirportPrague Airport0EconomyA Flight from Transavia France goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 11/7/2026 11:25:00 AM to Prague Airport, Prague Airport (Czech Republic) arriving at 11/7/2026 9:00:00 PM. 50 Economy ticket for $263 per person are available. Travel duration is 9h 35m
Cheapest Buses Saturday
Cheapest Flights Saturday
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FlixBus17h 25m010:00 PMLyonLyon Avenue Tony Garnier Bus Stop3:25 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/8/2026 10:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/9/2026 3:25:00 PM. 50 Economy ticket for $66 per person are available. Travel duration is 17h 25m
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FlixBus18h 10m010:00 PMLyonLyon Avenue Tony Garnier Bus Stop4:10 PMPragueČerný Most0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/8/2026 10:00:00 PM to Černý Most, Prague (Czech Republic) arriving at 11/9/2026 4:10:00 PM. 50 Economy ticket for $66 per person are available. Travel duration is 18h 10m
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FlixBus16h 30m05:20 AMLyonLyon Avenue Tony Garnier Bus Stop9:50 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/8/2026 5:20:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/8/2026 9:50:00 PM. 50 Economy ticket for $69 per person are available. Travel duration is 16h 30m
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FlixBus17h 5m09:30 PMLyonLyon Avenue Tony Garnier Bus Stop2:35 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/8/2026 9:30:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 11/9/2026 2:35:00 PM. 50 Economy ticket for $77 per person are available. Travel duration is 17h 5m
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FlixBus17h 15m09:30 PMLyonLyon Avenue Tony Garnier Bus Stop2:45 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/8/2026 9:30:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/9/2026 2:45:00 PM. 50 Economy ticket for $77 per person are available. Travel duration is 17h 15m
Cheapest Buses Sunday
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FlixBus17h 25m010:00 PMLyonLyon Avenue Tony Garnier Bus Stop3:25 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/9/2026 10:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/10/2026 3:25:00 PM. 50 Economy ticket for $61 per person are available. Travel duration is 17h 25m
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FlixBus14h 50m06:05 PMLyonLyon Avenue Tony Garnier Bus Stop8:55 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/9/2026 6:05:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 11/10/2026 8:55:00 AM. 50 Economy ticket for $61 per person are available. Travel duration is 14h 50m
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FlixBus18h 10m010:00 PMLyonLyon Avenue Tony Garnier Bus Stop4:10 PMPragueČerný Most0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/9/2026 10:00:00 PM to Černý Most, Prague (Czech Republic) arriving at 11/10/2026 4:10:00 PM. 50 Economy ticket for $61 per person are available. Travel duration is 18h 10m
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BlaBlaCar Bus21h 45m012:00 PMLyonPerrache Train Station9:45 AMPragueÚAN Florenc0EconomyA Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 11/9/2026 12:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/10/2026 9:45:00 AM. 50 Economy ticket for $72 per person are available. Travel duration is 21h 45m
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EasyJet Airline6h 35m09:45 AMLyons St. Exupery AirportLyons St. Exupery Airport4:20 PMPrague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 11/9/2026 9:45:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 11/9/2026 4:20:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 6h 35m
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Vueling Airlines15h 25m06:35 PMLyons St. Exupery AirportLyons St. Exupery Airport10:00 AMPrague AirportPrague Airport0EconomyA Flight from Vueling Airlines goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 11/9/2026 6:35:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 11/10/2026 10:00:00 AM. 50 Economy ticket for $127 per person are available. Travel duration is 15h 25m
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Brussels Airlines6h 0m011:55 AMLyons St. Exupery AirportLyons St. Exupery Airport5:55 PMPrague AirportPrague Airport0EconomyA Flight from Brussels Airlines goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 11/9/2026 11:55:00 AM to Prague Airport, Prague Airport (Czech Republic) arriving at 11/9/2026 5:55:00 PM. 50 Economy ticket for $176 per person are available. Travel duration is 6h 0m
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Lufthansa7h 30m06:30 AMLyons St. Exupery AirportLyons St. Exupery Airport2:00 PMPrague AirportPrague Airport0EconomyA Flight from Lufthansa goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 11/9/2026 6:30:00 AM to Prague Airport, Prague Airport (Czech Republic) arriving at 11/9/2026 2:00:00 PM. 50 Economy ticket for $181 per person are available. Travel duration is 7h 30m
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Eurowings12h 30m09:00 AMLyons St. Exupery AirportLyons St. Exupery Airport9:30 PMPrague AirportPrague Airport0EconomyA Flight from Eurowings goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 11/9/2026 9:00:00 AM to Prague Airport, Prague Airport (Czech Republic) arriving at 11/9/2026 9:30:00 PM. 50 Economy ticket for $191 per person are available. Travel duration is 12h 30m
Cheapest Buses Monday
Cheapest Flights Monday
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FlixBus16h 30m05:20 AMLyonLyon Avenue Tony Garnier Bus Stop9:50 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/10/2026 5:20:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/10/2026 9:50:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 16h 30m
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FlixBus18h 10m010:00 PMLyonLyon Avenue Tony Garnier Bus Stop4:10 PMPragueČerný Most0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/10/2026 10:00:00 PM to Černý Most, Prague (Czech Republic) arriving at 11/11/2026 4:10:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 18h 10m
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FlixBus19h 30m011:30 AMLyonLyon Avenue Tony Garnier Bus Stop7:00 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/10/2026 11:30:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 11/11/2026 7:00:00 AM. 50 Economy ticket for $66 per person are available. Travel duration is 19h 30m
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FlixBus17h 35m05:20 AMLyonLyon Avenue Tony Garnier Bus Stop10:55 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/10/2026 5:20:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 11/10/2026 10:55:00 PM. 50 Economy ticket for $66 per person are available. Travel duration is 17h 35m
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FlixBus19h 40m011:30 AMLyonLyon Avenue Tony Garnier Bus Stop7:10 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/10/2026 11:30:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/11/2026 7:10:00 AM. 50 Economy ticket for $66 per person are available. Travel duration is 19h 40m
Cheapest Buses Tuesday
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FlixBus22h 25m02:20 AMLyonLyon Avenue Tony Garnier Bus Stop12:45 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/11/2026 2:20:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 11/12/2026 12:45:00 AM. 50 Economy ticket for $70 per person are available. Travel duration is 22h 25m
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FlixBus24h 30m02:20 AMLyonLyon Avenue Tony Garnier Bus Stop2:50 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/11/2026 2:20:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 11/12/2026 2:50:00 AM. 50 Economy ticket for $70 per person are available. Travel duration is 24h 30m
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FlixBus19h 30m011:30 AMLyonLyon Avenue Tony Garnier Bus Stop7:00 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/11/2026 11:30:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 11/12/2026 7:00:00 AM. 50 Economy ticket for $70 per person are available. Travel duration is 19h 30m
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STARSHIPPER SAS20h 0m01:20 PMLyonLyon Avenue Tony Garnier Bus Stop9:20 AMPragueÚAN Florenc0EconomyA Bus from STARSHIPPER SAS goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/11/2026 1:20:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/12/2026 9:20:00 AM. 50 Economy ticket for $70 per person are available. Travel duration is 20h 0m
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EasyJet Airline1h 40m010:40 AMLyons St. Exupery AirportLyons St. Exupery Airport12:20 PMPrague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 11/11/2026 10:40:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 11/11/2026 12:20:00 PM. 50 Economy ticket for $99 per person are available. Travel duration is 1h 40m
Cheapest Buses Wednesday
Cheapest Flights Wednesday
What are the fastest trips from Lyon to Prague?
You can get to Prague from Lyon in just 1h 40m with a Flight from EasyJet Airline. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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FlixBus14h 50m06:05 PMLyonLyon Avenue Tony Garnier Bus Stop8:55 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/5/2026 6:05:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 11/6/2026 8:55:00 AM. 50 Economy ticket for $60 per person are available. Travel duration is 14h 50m
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FlixBus15h 15m06:05 PMLyonLyon Avenue Tony Garnier Bus Stop9:20 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/5/2026 6:05:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/6/2026 9:20:00 AM. 50 Economy ticket for $63 per person are available. Travel duration is 15h 15m
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FlixBus15h 55m05:00 PMLyons St. Exupery AirportLyons St. Exupery Airport8:55 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 11/5/2026 5:00:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 11/6/2026 8:55:00 AM. 50 Economy ticket for $74 per person are available. Travel duration is 15h 55m
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FlixBus16h 20m05:00 PMLyons St. Exupery AirportLyons St. Exupery Airport9:20 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 11/5/2026 5:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/6/2026 9:20:00 AM. 50 Economy ticket for $74 per person are available. Travel duration is 16h 20m
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FlixBus18h 10m010:00 PMLyonLyon Avenue Tony Garnier Bus Stop4:10 PMPragueČerný Most0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/5/2026 10:00:00 PM to Černý Most, Prague (Czech Republic) arriving at 11/6/2026 4:10:00 PM. 50 Economy ticket for $60 per person are available. Travel duration is 18h 10m
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Wizz Air23h 40m010:25 PMLyons St. Exupery AirportLyons St. Exupery Airport10:05 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Wizz Air goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 11/5/2026 10:25:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 11/6/2026 10:05:00 PM. 50 Economy ticket for $105 per person are available. Travel duration is 23h 40m
Fastest Buses Thursday
Fastest Flights Thursday
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FlixBus17h 25m010:00 PMLyonLyon Avenue Tony Garnier Bus Stop3:25 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/6/2026 10:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/7/2026 3:25:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 17h 25m
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FlixBus18h 10m010:00 PMLyonLyon Avenue Tony Garnier Bus Stop4:10 PMPragueČerný Most0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/6/2026 10:00:00 PM to Černý Most, Prague (Czech Republic) arriving at 11/7/2026 4:10:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 18h 10m
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BlaBlaCar Bus21h 45m012:00 PMLyonPerrache Train Station9:45 AMPragueÚAN Florenc0EconomyA Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 11/6/2026 12:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/7/2026 9:45:00 AM. 50 Economy ticket for $70 per person are available. Travel duration is 21h 45m
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STARSHIPPER SAS21h 55m04:40 PMLyons St. Exupery AirportLyons St. Exupery Airport2:35 PMPragueWilsonova Bus Station0EconomyA Bus from STARSHIPPER SAS goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 11/6/2026 4:40:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 11/7/2026 2:35:00 PM. 50 Economy ticket for $79 per person are available. Travel duration is 21h 55m
Fastest Buses Friday
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Transavia France9h 35m011:25 AMLyons St. Exupery AirportLyons St. Exupery Airport9:00 PMPrague AirportPrague Airport0EconomyA Flight from Transavia France goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 11/7/2026 11:25:00 AM to Prague Airport, Prague Airport (Czech Republic) arriving at 11/7/2026 9:00:00 PM. 50 Economy ticket for $263 per person are available. Travel duration is 9h 35m
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Wizz Air17h 25m011:15 PMLyons St. Exupery AirportLyons St. Exupery Airport4:40 PMPrague AirportPrague Airport0EconomyA Flight from Wizz Air goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 11/7/2026 11:15:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 11/8/2026 4:40:00 PM. 50 Economy ticket for $107 per person are available. Travel duration is 17h 25m
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AJet21h 20m02:45 PMLyons St. Exupery AirportLyons St. Exupery Airport12:05 PMPrague AirportPrague Airport0EconomyA Flight from AJet goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 11/7/2026 2:45:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 11/8/2026 12:05:00 PM. 50 Economy ticket for $257 per person are available. Travel duration is 21h 20m
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Vueling Airlines21h 35m07:15 PMLyons St. Exupery AirportLyons St. Exupery Airport4:50 PMPrague AirportPrague Airport0EconomyA Flight from Vueling Airlines goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 11/7/2026 7:15:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 11/8/2026 4:50:00 PM. 50 Economy ticket for $211 per person are available. Travel duration is 21h 35m
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Iberia21h 35m07:15 PMLyons St. Exupery AirportLyons St. Exupery Airport4:50 PMPrague AirportPrague Airport0EconomyA Flight from Iberia goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 11/7/2026 7:15:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 11/8/2026 4:50:00 PM. 50 Economy ticket for $212 per person are available. Travel duration is 21h 35m
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FlixBus14h 50m06:05 PMLyonLyon Avenue Tony Garnier Bus Stop8:55 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/7/2026 6:05:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 11/8/2026 8:55:00 AM. 50 Economy ticket for $66 per person are available. Travel duration is 14h 50m
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FlixBus15h 15m06:05 PMLyonLyon Avenue Tony Garnier Bus Stop9:20 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/7/2026 6:05:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/8/2026 9:20:00 AM. 50 Economy ticket for $66 per person are available. Travel duration is 15h 15m
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FlixBus17h 5m09:30 PMLyonLyon Avenue Tony Garnier Bus Stop2:35 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/7/2026 9:30:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 11/8/2026 2:35:00 PM. 50 Economy ticket for $66 per person are available. Travel duration is 17h 5m
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FlixBus17h 15m09:30 PMLyonLyon Avenue Tony Garnier Bus Stop2:45 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/7/2026 9:30:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/8/2026 2:45:00 PM. 50 Economy ticket for $66 per person are available. Travel duration is 17h 15m
Fastest Flights Saturday
Fastest Buses Saturday
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FlixBus16h 30m05:20 AMLyonLyon Avenue Tony Garnier Bus Stop9:50 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/8/2026 5:20:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/8/2026 9:50:00 PM. 50 Economy ticket for $69 per person are available. Travel duration is 16h 30m
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FlixBus17h 5m09:30 PMLyonLyon Avenue Tony Garnier Bus Stop2:35 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/8/2026 9:30:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 11/9/2026 2:35:00 PM. 50 Economy ticket for $77 per person are available. Travel duration is 17h 5m
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FlixBus17h 15m09:30 PMLyonLyon Avenue Tony Garnier Bus Stop2:45 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/8/2026 9:30:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/9/2026 2:45:00 PM. 50 Economy ticket for $77 per person are available. Travel duration is 17h 15m
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FlixBus17h 25m010:00 PMLyonLyon Avenue Tony Garnier Bus Stop3:25 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/8/2026 10:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/9/2026 3:25:00 PM. 50 Economy ticket for $66 per person are available. Travel duration is 17h 25m
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FlixBus18h 10m010:00 PMLyonLyon Avenue Tony Garnier Bus Stop4:10 PMPragueČerný Most0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/8/2026 10:00:00 PM to Černý Most, Prague (Czech Republic) arriving at 11/9/2026 4:10:00 PM. 50 Economy ticket for $66 per person are available. Travel duration is 18h 10m
Fastest Buses Sunday
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Brussels Airlines6h 0m011:55 AMLyons St. Exupery AirportLyons St. Exupery Airport5:55 PMPrague AirportPrague Airport0EconomyA Flight from Brussels Airlines goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 11/9/2026 11:55:00 AM to Prague Airport, Prague Airport (Czech Republic) arriving at 11/9/2026 5:55:00 PM. 50 Economy ticket for $176 per person are available. Travel duration is 6h 0m
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EasyJet Airline6h 35m09:45 AMLyons St. Exupery AirportLyons St. Exupery Airport4:20 PMPrague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 11/9/2026 9:45:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 11/9/2026 4:20:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 6h 35m
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Lufthansa7h 30m06:30 AMLyons St. Exupery AirportLyons St. Exupery Airport2:00 PMPrague AirportPrague Airport0EconomyA Flight from Lufthansa goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 11/9/2026 6:30:00 AM to Prague Airport, Prague Airport (Czech Republic) arriving at 11/9/2026 2:00:00 PM. 50 Economy ticket for $181 per person are available. Travel duration is 7h 30m
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Eurowings12h 30m09:00 AMLyons St. Exupery AirportLyons St. Exupery Airport9:30 PMPrague AirportPrague Airport0EconomyA Flight from Eurowings goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 11/9/2026 9:00:00 AM to Prague Airport, Prague Airport (Czech Republic) arriving at 11/9/2026 9:30:00 PM. 50 Economy ticket for $191 per person are available. Travel duration is 12h 30m
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Vueling Airlines15h 25m06:35 PMLyons St. Exupery AirportLyons St. Exupery Airport10:00 AMPrague AirportPrague Airport0EconomyA Flight from Vueling Airlines goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 11/9/2026 6:35:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 11/10/2026 10:00:00 AM. 50 Economy ticket for $127 per person are available. Travel duration is 15h 25m
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FlixBus14h 50m06:05 PMLyonLyon Avenue Tony Garnier Bus Stop8:55 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/9/2026 6:05:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 11/10/2026 8:55:00 AM. 50 Economy ticket for $61 per person are available. Travel duration is 14h 50m
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FlixBus17h 25m010:00 PMLyonLyon Avenue Tony Garnier Bus Stop3:25 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/9/2026 10:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/10/2026 3:25:00 PM. 50 Economy ticket for $61 per person are available. Travel duration is 17h 25m
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FlixBus18h 10m010:00 PMLyonLyon Avenue Tony Garnier Bus Stop4:10 PMPragueČerný Most0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/9/2026 10:00:00 PM to Černý Most, Prague (Czech Republic) arriving at 11/10/2026 4:10:00 PM. 50 Economy ticket for $61 per person are available. Travel duration is 18h 10m
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BlaBlaCar Bus21h 45m012:00 PMLyonPerrache Train Station9:45 AMPragueÚAN Florenc0EconomyA Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 11/9/2026 12:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/10/2026 9:45:00 AM. 50 Economy ticket for $72 per person are available. Travel duration is 21h 45m
Fastest Flights Monday
Fastest Buses Monday
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FlixBus16h 30m05:20 AMLyonLyon Avenue Tony Garnier Bus Stop9:50 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/10/2026 5:20:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/10/2026 9:50:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 16h 30m
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FlixBus17h 35m05:20 AMLyonLyon Avenue Tony Garnier Bus Stop10:55 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/10/2026 5:20:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 11/10/2026 10:55:00 PM. 50 Economy ticket for $66 per person are available. Travel duration is 17h 35m
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FlixBus18h 10m010:00 PMLyonLyon Avenue Tony Garnier Bus Stop4:10 PMPragueČerný Most0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/10/2026 10:00:00 PM to Černý Most, Prague (Czech Republic) arriving at 11/11/2026 4:10:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 18h 10m
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FlixBus19h 30m011:30 AMLyonLyon Avenue Tony Garnier Bus Stop7:00 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/10/2026 11:30:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 11/11/2026 7:00:00 AM. 50 Economy ticket for $66 per person are available. Travel duration is 19h 30m
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FlixBus19h 40m011:30 AMLyonLyon Avenue Tony Garnier Bus Stop7:10 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/10/2026 11:30:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/11/2026 7:10:00 AM. 50 Economy ticket for $66 per person are available. Travel duration is 19h 40m
Fastest Buses Tuesday
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EasyJet Airline1h 40m010:40 AMLyons St. Exupery AirportLyons St. Exupery Airport12:20 PMPrague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 11/11/2026 10:40:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 11/11/2026 12:20:00 PM. 50 Economy ticket for $99 per person are available. Travel duration is 1h 40m
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FlixBus19h 30m011:30 AMLyonLyon Avenue Tony Garnier Bus Stop7:00 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/11/2026 11:30:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 11/12/2026 7:00:00 AM. 50 Economy ticket for $70 per person are available. Travel duration is 19h 30m
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STARSHIPPER SAS20h 0m01:20 PMLyonLyon Avenue Tony Garnier Bus Stop9:20 AMPragueÚAN Florenc0EconomyA Bus from STARSHIPPER SAS goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/11/2026 1:20:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 11/12/2026 9:20:00 AM. 50 Economy ticket for $70 per person are available. Travel duration is 20h 0m
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FlixBus22h 25m02:20 AMLyonLyon Avenue Tony Garnier Bus Stop12:45 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/11/2026 2:20:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 11/12/2026 12:45:00 AM. 50 Economy ticket for $70 per person are available. Travel duration is 22h 25m
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FlixBus24h 30m02:20 AMLyonLyon Avenue Tony Garnier Bus Stop2:50 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 11/11/2026 2:20:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 11/12/2026 2:50:00 AM. 50 Economy ticket for $70 per person are available. Travel duration is 24h 30m
Fastest Flights Wednesday
Fastest Buses Wednesday
Here you will find all operators and timetables for a
Bus from Lyon to Prague
What are the most popular stations in Lyon and Prague?
In Lyon, you will usually depart from Part-Dieu Train Station, Perrache Train Station or Perrache Bus Stop, while in Prague you will be arriving at Wilsonova Bus Station, ÚAN Florenc or Roztyly, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Prague from Lyon? With 6 connections between 4 Flight and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Lyon and Prague, you can pay as low as $60 with a Bus from FlixBus.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from EasyJet Airline: you will get to Prague in just 1h 40m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Lyon and Prague are FlixBus, BlaBlaCar Bus and STARSHIPPER SAS, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Lyon and Prague is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Caluire-et-Cuire or to Horoměřice, and look at flights from Lyons St. Exupery Airport, and landing at Prague Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Lyon to Prague?
The most popular companies between Lyon and Prague, are FlixBus, BlaBlaCar Bus and STARSHIPPER SAS. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus, BlaBlaCar Bus and STARSHIPPER SAS
Airlines: Wizz Air, Vueling Airlines, EasyJet Airline and 6 more.
All you need to know when you travel from Lyon to Prague
Check all information on comfort and services on all modes of transports from Lyon to Prague. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Lyon to Prague
How can I reach Prague from Lyon?
Every day, there are on average 6 connections between Flight and Bus, with which you can get to Prague from Lyon.
How far is Prague from Lyon?
The distance between Lyon and Prague is 535.0 miles.
What is the most ecofriendly mode of transport between Lyon and Prague?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 23 kgs of CO2, a train 30 kgs, a car 146 kgs, and a flight 212 kgs.
What is the cheapest mode of transport from Lyon to Prague?
You can get to Prague with just $60 by taking a Bus from FlixBus.
What is the fastest way to get from Lyon to Prague?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Prague in just 1h 40m with a Flight from EasyJet Airline.
More routes to Lyon and to Prague
Looking for more options? Here you can see the most popular routes to Lyon and to Prague. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Lyon
- Alicante to Lyon
- Barcelona to Lyon
- Basel to Lyon
- Berlin to Lyon
- Bordeaux to Lyon
- Brussels to Lyon
- Clermont-Ferrand to Lyon
- Geneva Airport to Lyon
- Geneva to Lyon
- Grenoble to Lyon
- Lausanne to Lyon
- London to Lyon
- Lyons St. Exupery Airport to Lyon
- Marseille to Lyon
- Milan to Lyon
- Nice to Lyon
- Nimes to Lyon
- Paris Orly Airport to Lyon
- Paris to Lyon
- Perpignan to Lyon
- Toulouse to Lyon
- Turin to Lyon
- Valencia to Lyon
- Viseu to Lyon
- Trips to Prague
- Antwerp to Prague
- Berlin to Prague
- Bern to Prague
- Brussels to Prague
- Budapest to Prague
- Chemnitz to Prague
- Dresden to Prague
- Frankfurt am Main Airport to Prague
- Humpolec to Prague
- Innsbruck to Prague
- Jihlava to Prague
- Karlovy Vary to Prague
- Katowice to Prague
- Leipzig to Prague
- London to Prague
- Mannheim to Prague
- Mostar to Prague
- Munich to Prague
- Olomouc to Prague
- Ostrava to Prague
- Valencia to Prague
- Vienna Airport to Prague
- Vienna to Prague
- Wroclaw to Prague
