What is the best way to travel from Lyon to Prague?
Looking for a trip? Compare all the available Buses and Flights for the journey to Prague from Lyon. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
What is the cheapest way to reach Prague from Lyon?
You can get to Prague with just $71 by taking a Bus from BlaBlaCar Bus, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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Volotea1h 40m05:40 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station7:20 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Volotea goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/24/2025 5:40:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/24/2025 7:20:00 PM. 50 Economy ticket for $91 per person are available. Travel duration is 1h 40m
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EasyJet Airline1h 40m01:40 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station3:20 PMPrague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/24/2025 1:40:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/24/2025 3:20:00 PM. 50 Economy ticket for $118 per person are available. Travel duration is 1h 40m
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Vueling Airlines14h 15m07:55 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station10:10 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Vueling Airlines goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/24/2025 7:55:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/25/2025 10:10:00 AM. 50 Economy ticket for $190 per person are available. Travel duration is 14h 15m
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Air France14h 35m06:30 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station9:05 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Air France goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/24/2025 6:30:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/25/2025 9:05:00 AM. 50 Economy ticket for $211 per person are available. Travel duration is 14h 35m
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LOT Polish Airlines / Polskie Linie Lotnicze13h 35m07:15 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station8:50 AMPrague AirportPrague Airport - T1/20EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/24/2025 7:15:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/25/2025 8:50:00 AM. 50 Economy ticket for $224 per person are available. Travel duration is 13h 35m
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FlixBus16h 55m09:00 PMLyonPerrache Bus Stop1:55 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/24/2025 9:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/25/2025 1:55:00 PM. 50 Economy ticket for $97 per person are available. Travel duration is 16h 55m
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FlixBus17h 5m09:00 PMLyonPerrache Bus Stop2:05 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/24/2025 9:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/25/2025 2:05:00 PM. 50 Economy ticket for $97 per person are available. Travel duration is 17h 5m
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FlixBus14h 40m06:15 PMLyonPerrache Bus Stop8:55 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/24/2025 6:15:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 12/25/2025 8:55:00 AM. 50 Economy ticket for $102 per person are available. Travel duration is 14h 40m
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FlixBus15h 5m06:15 PMLyonPerrache Bus Stop9:20 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/24/2025 6:15:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/25/2025 9:20:00 AM. 50 Economy ticket for $102 per person are available. Travel duration is 15h 5m
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FlixBus17h 45m05:05 PMLyonPerrache Bus Stop10:50 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/24/2025 5:05:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/25/2025 10:50:00 AM. 50 Economy ticket for $114 per person are available. Travel duration is 17h 45m
Cheapest Flights Wednesday
Cheapest Buses Wednesday
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Volotea1h 40m07:45 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station9:25 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Volotea goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/25/2025 7:45:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/25/2025 9:25:00 PM. 50 Economy ticket for $73 per person are available. Travel duration is 1h 40m
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Air Bagan23h 30m02:30 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station2:00 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Air Bagan goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/25/2025 2:30:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/26/2025 2:00:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 23h 30m
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LC Perú7h 15m09:30 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station4:45 PMPrague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/25/2025 9:30:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/25/2025 4:45:00 PM. 50 Economy ticket for $133 per person are available. Travel duration is 7h 15m
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EasyJet Airline1h 40m06:15 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station7:55 PMPrague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/25/2025 6:15:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/25/2025 7:55:00 PM. 50 Economy ticket for $138 per person are available. Travel duration is 1h 40m
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Austrian Airlines3h 10m012:50 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station4:00 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Austrian Airlines goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/25/2025 12:50:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/25/2025 4:00:00 PM. 50 Economy ticket for $208 per person are available. Travel duration is 3h 10m
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FlixBus14h 40m06:15 PMLyonPerrache Bus Stop8:55 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/25/2025 6:15:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 12/26/2025 8:55:00 AM. 50 Economy ticket for $99 per person are available. Travel duration is 14h 40m
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FlixBus16h 55m09:00 PMLyonPerrache Bus Stop1:55 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/25/2025 9:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/26/2025 1:55:00 PM. 50 Economy ticket for $99 per person are available. Travel duration is 16h 55m
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FlixBus15h 5m06:15 PMLyonPerrache Bus Stop9:20 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/25/2025 6:15:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/26/2025 9:20:00 AM. 50 Economy ticket for $99 per person are available. Travel duration is 15h 5m
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FlixBus17h 5m09:00 PMLyonPerrache Bus Stop2:05 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/25/2025 9:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/26/2025 2:05:00 PM. 50 Economy ticket for $99 per person are available. Travel duration is 17h 5m
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FlixBus17h 25m010:00 PMLyonPerrache Bus Stop3:25 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/25/2025 10:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/26/2025 3:25:00 PM. 50 Economy ticket for $99 per person are available. Travel duration is 17h 25m
Cheapest Flights Thursday
Cheapest Buses Thursday
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Volotea1h 40m04:40 PMLyons St. Exupery AirportLyons St. Exupery Airport6:20 PMPrague AirportPrague Airport0EconomyA Flight from Volotea goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 12/26/2025 4:40:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 12/26/2025 6:20:00 PM. 50 Economy ticket for $89 per person are available. Travel duration is 1h 40m
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LC Perú13h 30m08:35 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station10:05 PMPrague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/26/2025 8:35:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/26/2025 10:05:00 PM. 50 Economy ticket for $124 per person are available. Travel duration is 13h 30m
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LOT Polish Airlines / Polskie Linie Lotnicze25h 50m07:00 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station8:50 AMPrague AirportPrague Airport - T1/20EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/26/2025 7:00:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/27/2025 8:50:00 AM. 50 Economy ticket for $164 per person are available. Travel duration is 25h 50m
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EasyJet Airline23h 50m09:20 PMLyons St. Exupery AirportLyons St. Exupery Airport9:10 PMPrague AirportPrague Airport0EconomyA Flight from EasyJet Airline goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 12/26/2025 9:20:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 12/27/2025 9:10:00 PM. 50 Economy ticket for $199 per person are available. Travel duration is 23h 50m
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Wizz Air19h 55m07:55 PMLyons St. Exupery AirportLyons St. Exupery Airport3:50 PMPrague AirportPrague Airport0EconomyA Flight from Wizz Air goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 12/26/2025 7:55:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 12/27/2025 3:50:00 PM. 50 Economy ticket for $265 per person are available. Travel duration is 19h 55m
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FlixBus16h 55m09:00 PMLyonPerrache Bus Stop1:55 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/26/2025 9:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/27/2025 1:55:00 PM. 50 Economy ticket for $105 per person are available. Travel duration is 16h 55m
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FlixBus16h 30m05:20 AMLyonPerrache Bus Stop9:50 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/26/2025 5:20:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/26/2025 9:50:00 PM. 50 Economy ticket for $105 per person are available. Travel duration is 16h 30m
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FlixBus17h 5m09:00 PMLyonPerrache Bus Stop2:05 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/26/2025 9:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/27/2025 2:05:00 PM. 50 Economy ticket for $105 per person are available. Travel duration is 17h 5m
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FlixBus17h 25m010:00 PMLyonPerrache Bus Stop3:25 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/26/2025 10:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/27/2025 3:25:00 PM. 50 Economy ticket for $105 per person are available. Travel duration is 17h 25m
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FlixBus18h 10m010:00 PMLyonPerrache Bus Stop4:10 PMPragueČerný Most0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/26/2025 10:00:00 PM to Černý Most, Prague (Czech Republic) arriving at 12/27/2025 4:10:00 PM. 50 Economy ticket for $105 per person are available. Travel duration is 18h 10m
Cheapest Flights Friday
Cheapest Buses Friday
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BlaBlaCar Bus16h 55m03:05 AMLyonPerrache Bus Stop8:00 PMPragueÚAN Florenc0EconomyA Bus from BlaBlaCar Bus goes from Perrache Bus Stop, Lyon (France) at 12/27/2025 3:05:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/27/2025 8:00:00 PM. 50 Economy ticket for $71 per person are available. Travel duration is 16h 55m
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BlaBlaCar Bus16h 55m03:05 AMLyonPerrache Train Station8:00 PMPragueÚAN Florenc0EconomyA Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 12/27/2025 3:05:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/27/2025 8:00:00 PM. 50 Economy ticket for $71 per person are available. Travel duration is 16h 55m
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FlixBus17h 45m05:05 PMLyonPerrache Bus Stop10:50 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/27/2025 5:05:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/28/2025 10:50:00 AM. 50 Economy ticket for $105 per person are available. Travel duration is 17h 45m
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FlixBus16h 55m09:00 PMLyonPerrache Bus Stop1:55 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/27/2025 9:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/28/2025 1:55:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 16h 55m
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FlixBus17h 5m09:00 PMLyonPerrache Bus Stop2:05 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/27/2025 9:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/28/2025 2:05:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 17h 5m
Cheapest Buses Saturday
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BlaBlaCar Bus16h 55m03:05 AMLyonPerrache Bus Stop8:00 PMPragueÚAN Florenc0EconomyA Bus from BlaBlaCar Bus goes from Perrache Bus Stop, Lyon (France) at 12/28/2025 3:05:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/28/2025 8:00:00 PM. 50 Economy ticket for $71 per person are available. Travel duration is 16h 55m
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BlaBlaCar Bus16h 55m03:05 AMLyonPerrache Train Station8:00 PMPragueÚAN Florenc0EconomyA Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 12/28/2025 3:05:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/28/2025 8:00:00 PM. 50 Economy ticket for $82 per person are available. Travel duration is 16h 55m
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FlixBus19h 0m03:15 AMLyonPerrache Bus Stop10:15 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/28/2025 3:15:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/28/2025 10:15:00 PM. 50 Economy ticket for $104 per person are available. Travel duration is 19h 0m
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FlixBus17h 45m05:05 PMLyonPerrache Bus Stop10:50 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/28/2025 5:05:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/29/2025 10:50:00 AM. 50 Economy ticket for $105 per person are available. Travel duration is 17h 45m
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FlixBus17h 25m010:00 PMLyonPerrache Bus Stop3:25 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/28/2025 10:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/29/2025 3:25:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 17h 25m
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Volotea1h 40m06:15 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station7:55 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Volotea goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/28/2025 6:15:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/28/2025 7:55:00 AM. 50 Economy ticket for $73 per person are available. Travel duration is 1h 40m
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EasyJet Airline1h 40m05:45 PMLyons St. Exupery AirportLyons St. Exupery Airport7:25 PMPrague AirportPrague Airport0EconomyA Flight from EasyJet Airline goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 12/28/2025 5:45:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 12/28/2025 7:25:00 PM. 50 Economy ticket for $147 per person are available. Travel duration is 1h 40m
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Skyscanner1h 40m05:45 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station7:25 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Skyscanner goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/28/2025 5:45:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/28/2025 7:25:00 PM. 50 Economy ticket for $186 per person are available. Travel duration is 1h 40m
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LOT Polish Airlines / Polskie Linie Lotnicze13h 35m07:15 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station8:50 AMPrague AirportPrague Airport - T1/20EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/28/2025 7:15:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/29/2025 8:50:00 AM. 50 Economy ticket for $193 per person are available. Travel duration is 13h 35m
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Vueling Airlines18h 5m011:20 PMLyons St. Exupery AirportLyons St. Exupery Airport5:25 PMPrague AirportPrague Airport0EconomyA Flight from Vueling Airlines goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 12/28/2025 11:20:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 12/29/2025 5:25:00 PM. 50 Economy ticket for $208 per person are available. Travel duration is 18h 5m
Cheapest Buses Sunday
Cheapest Flights Sunday
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FlixBus17h 45m05:05 PMLyonPerrache Bus Stop10:50 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/29/2025 5:05:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/30/2025 10:50:00 AM. 50 Economy ticket for $93 per person are available. Travel duration is 17h 45m
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FlixBus19h 0m03:15 AMLyonPerrache Bus Stop10:15 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/29/2025 3:15:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/29/2025 10:15:00 PM. 50 Economy ticket for $94 per person are available. Travel duration is 19h 0m
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FlixBus20h 30m09:30 AMLyonPerrache Bus Stop6:00 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/29/2025 9:30:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/30/2025 6:00:00 AM. 50 Economy ticket for $94 per person are available. Travel duration is 20h 30m
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FlixBus20h 45m09:30 AMLyonPerrache Bus Stop6:15 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/29/2025 9:30:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/30/2025 6:15:00 AM. 50 Economy ticket for $94 per person are available. Travel duration is 20h 45m
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FlixBus19h 5m05:20 AMLyonPerrache Bus Stop12:25 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/29/2025 5:20:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/30/2025 12:25:00 AM. 50 Economy ticket for $96 per person are available. Travel duration is 19h 5m
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LC Perú13h 30m08:35 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station10:05 PMPrague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/29/2025 8:35:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/29/2025 10:05:00 PM. 50 Economy ticket for $135 per person are available. Travel duration is 13h 30m
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EasyJet Airline1h 40m011:40 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station1:20 PMPrague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/29/2025 11:40:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/29/2025 1:20:00 PM. 50 Economy ticket for $157 per person are available. Travel duration is 1h 40m
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Volotea1h 40m09:55 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station11:35 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Volotea goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/29/2025 9:55:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/29/2025 11:35:00 AM. 50 Economy ticket for $174 per person are available. Travel duration is 1h 40m
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LOT Polish Airlines / Polskie Linie Lotnicze7h 40m011:10 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station6:50 PMPrague AirportPrague Airport - T1/20EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/29/2025 11:10:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/29/2025 6:50:00 PM. 50 Economy ticket for $203 per person are available. Travel duration is 7h 40m
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Lufthansa CityLine4h 0m06:25 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station10:25 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Lufthansa CityLine goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/29/2025 6:25:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/29/2025 10:25:00 PM. 50 Economy ticket for $240 per person are available. Travel duration is 4h 0m
Cheapest Buses Monday
Cheapest Flights Monday
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Volotea1h 40m06:30 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station8:10 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Volotea goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/30/2025 6:30:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/30/2025 8:10:00 AM. 50 Economy ticket for $84 per person are available. Travel duration is 1h 40m
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LC Perú24h 30m09:30 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station10:00 PMPrague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/30/2025 9:30:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/31/2025 10:00:00 PM. 50 Economy ticket for $96 per person are available. Travel duration is 24h 30m
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Wizz Air17h 50m010:45 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station4:35 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Wizz Air goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/30/2025 10:45:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/31/2025 4:35:00 PM. 50 Economy ticket for $104 per person are available. Travel duration is 17h 50m
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EasyJet Airline25h 25m07:00 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station8:25 AMPrague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/30/2025 7:00:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/31/2025 8:25:00 AM. 50 Economy ticket for $109 per person are available. Travel duration is 25h 25m
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LOT Polish Airlines / Polskie Linie Lotnicze7h 40m011:10 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station6:50 PMPrague AirportPrague Airport - T1/20EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/30/2025 11:10:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/30/2025 6:50:00 PM. 50 Economy ticket for $193 per person are available. Travel duration is 7h 40m
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FlixBus17h 35m05:20 AMLyonPerrache Bus Stop10:55 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/30/2025 5:20:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 12/30/2025 10:55:00 PM. 50 Economy ticket for $96 per person are available. Travel duration is 17h 35m
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FlixBus17h 45m05:05 PMLyonPerrache Bus Stop10:50 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/30/2025 5:05:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/31/2025 10:50:00 AM. 50 Economy ticket for $96 per person are available. Travel duration is 17h 45m
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FlixBus19h 5m05:20 AMLyonPerrache Bus Stop12:25 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/30/2025 5:20:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/31/2025 12:25:00 AM. 50 Economy ticket for $97 per person are available. Travel duration is 19h 5m
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FlixBus18h 45m03:30 AMLyonPerrache Bus Stop10:15 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/30/2025 3:30:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/30/2025 10:15:00 PM. 50 Economy ticket for $98 per person are available. Travel duration is 18h 45m
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FlixBus19h 45m01:25 AMLyonPerrache Bus Stop9:10 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/30/2025 1:25:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 12/30/2025 9:10:00 PM. 50 Economy ticket for $101 per person are available. Travel duration is 19h 45m
Cheapest Flights Tuesday
Cheapest Buses Tuesday
What are the fastest trips from Lyon to Prague?
You can get to Prague from Lyon in just 1h 40m with a Flight from Volotea. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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Volotea1h 40m05:40 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station7:20 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Volotea goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/24/2025 5:40:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/24/2025 7:20:00 PM. 50 Economy ticket for $91 per person are available. Travel duration is 1h 40m
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EasyJet Airline1h 40m01:40 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station3:20 PMPrague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/24/2025 1:40:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/24/2025 3:20:00 PM. 50 Economy ticket for $118 per person are available. Travel duration is 1h 40m
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LOT Polish Airlines / Polskie Linie Lotnicze13h 35m07:15 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station8:50 AMPrague AirportPrague Airport - T1/20EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/24/2025 7:15:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/25/2025 8:50:00 AM. 50 Economy ticket for $224 per person are available. Travel duration is 13h 35m
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Vueling Airlines14h 15m07:55 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station10:10 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Vueling Airlines goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/24/2025 7:55:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/25/2025 10:10:00 AM. 50 Economy ticket for $190 per person are available. Travel duration is 14h 15m
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Air France14h 35m06:30 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station9:05 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Air France goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/24/2025 6:30:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/25/2025 9:05:00 AM. 50 Economy ticket for $211 per person are available. Travel duration is 14h 35m
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FlixBus14h 40m06:15 PMLyonPerrache Bus Stop8:55 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/24/2025 6:15:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 12/25/2025 8:55:00 AM. 50 Economy ticket for $102 per person are available. Travel duration is 14h 40m
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FlixBus15h 5m06:15 PMLyonPerrache Bus Stop9:20 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/24/2025 6:15:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/25/2025 9:20:00 AM. 50 Economy ticket for $102 per person are available. Travel duration is 15h 5m
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FlixBus16h 55m09:00 PMLyonPerrache Bus Stop1:55 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/24/2025 9:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/25/2025 1:55:00 PM. 50 Economy ticket for $97 per person are available. Travel duration is 16h 55m
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FlixBus17h 5m09:00 PMLyonPerrache Bus Stop2:05 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/24/2025 9:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/25/2025 2:05:00 PM. 50 Economy ticket for $97 per person are available. Travel duration is 17h 5m
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FlixBus17h 45m05:05 PMLyonPerrache Bus Stop10:50 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/24/2025 5:05:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/25/2025 10:50:00 AM. 50 Economy ticket for $114 per person are available. Travel duration is 17h 45m
Fastest Flights Wednesday
Fastest Buses Wednesday
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Volotea1h 40m07:45 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station9:25 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Volotea goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/25/2025 7:45:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/25/2025 9:25:00 PM. 50 Economy ticket for $73 per person are available. Travel duration is 1h 40m
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EasyJet Airline1h 40m06:15 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station7:55 PMPrague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/25/2025 6:15:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/25/2025 7:55:00 PM. 50 Economy ticket for $138 per person are available. Travel duration is 1h 40m
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Austrian Airlines3h 10m012:50 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station4:00 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Austrian Airlines goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/25/2025 12:50:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/25/2025 4:00:00 PM. 50 Economy ticket for $208 per person are available. Travel duration is 3h 10m
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LC Perú7h 15m09:30 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station4:45 PMPrague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/25/2025 9:30:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/25/2025 4:45:00 PM. 50 Economy ticket for $133 per person are available. Travel duration is 7h 15m
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Air Bagan23h 30m02:30 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station2:00 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Air Bagan goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/25/2025 2:30:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/26/2025 2:00:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 23h 30m
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FlixBus14h 40m06:15 PMLyonPerrache Bus Stop8:55 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/25/2025 6:15:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 12/26/2025 8:55:00 AM. 50 Economy ticket for $99 per person are available. Travel duration is 14h 40m
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FlixBus15h 5m06:15 PMLyonPerrache Bus Stop9:20 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/25/2025 6:15:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/26/2025 9:20:00 AM. 50 Economy ticket for $99 per person are available. Travel duration is 15h 5m
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FlixBus16h 55m09:00 PMLyonPerrache Bus Stop1:55 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/25/2025 9:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/26/2025 1:55:00 PM. 50 Economy ticket for $99 per person are available. Travel duration is 16h 55m
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FlixBus17h 5m09:00 PMLyonPerrache Bus Stop2:05 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/25/2025 9:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/26/2025 2:05:00 PM. 50 Economy ticket for $99 per person are available. Travel duration is 17h 5m
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FlixBus17h 25m010:00 PMLyonPerrache Bus Stop3:25 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/25/2025 10:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/26/2025 3:25:00 PM. 50 Economy ticket for $99 per person are available. Travel duration is 17h 25m
Fastest Flights Thursday
Fastest Buses Thursday
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Volotea1h 40m04:40 PMLyons St. Exupery AirportLyons St. Exupery Airport6:20 PMPrague AirportPrague Airport0EconomyA Flight from Volotea goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 12/26/2025 4:40:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 12/26/2025 6:20:00 PM. 50 Economy ticket for $89 per person are available. Travel duration is 1h 40m
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LC Perú13h 30m08:35 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station10:05 PMPrague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/26/2025 8:35:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/26/2025 10:05:00 PM. 50 Economy ticket for $124 per person are available. Travel duration is 13h 30m
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Wizz Air19h 55m07:55 PMLyons St. Exupery AirportLyons St. Exupery Airport3:50 PMPrague AirportPrague Airport0EconomyA Flight from Wizz Air goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 12/26/2025 7:55:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 12/27/2025 3:50:00 PM. 50 Economy ticket for $265 per person are available. Travel duration is 19h 55m
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EasyJet Airline23h 50m09:20 PMLyons St. Exupery AirportLyons St. Exupery Airport9:10 PMPrague AirportPrague Airport0EconomyA Flight from EasyJet Airline goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 12/26/2025 9:20:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 12/27/2025 9:10:00 PM. 50 Economy ticket for $199 per person are available. Travel duration is 23h 50m
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LOT Polish Airlines / Polskie Linie Lotnicze25h 50m07:00 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station8:50 AMPrague AirportPrague Airport - T1/20EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/26/2025 7:00:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/27/2025 8:50:00 AM. 50 Economy ticket for $164 per person are available. Travel duration is 25h 50m
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FlixBus16h 30m05:20 AMLyonPerrache Bus Stop9:50 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/26/2025 5:20:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/26/2025 9:50:00 PM. 50 Economy ticket for $105 per person are available. Travel duration is 16h 30m
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FlixBus16h 55m09:00 PMLyonPerrache Bus Stop1:55 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/26/2025 9:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/27/2025 1:55:00 PM. 50 Economy ticket for $105 per person are available. Travel duration is 16h 55m
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FlixBus17h 5m09:00 PMLyonPerrache Bus Stop2:05 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/26/2025 9:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/27/2025 2:05:00 PM. 50 Economy ticket for $105 per person are available. Travel duration is 17h 5m
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FlixBus17h 25m010:00 PMLyonPerrache Bus Stop3:25 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/26/2025 10:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/27/2025 3:25:00 PM. 50 Economy ticket for $105 per person are available. Travel duration is 17h 25m
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FlixBus18h 10m010:00 PMLyonPerrache Bus Stop4:10 PMPragueČerný Most0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/26/2025 10:00:00 PM to Černý Most, Prague (Czech Republic) arriving at 12/27/2025 4:10:00 PM. 50 Economy ticket for $105 per person are available. Travel duration is 18h 10m
Fastest Flights Friday
Fastest Buses Friday
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BlaBlaCar Bus16h 55m03:05 AMLyonPerrache Bus Stop8:00 PMPragueÚAN Florenc0EconomyA Bus from BlaBlaCar Bus goes from Perrache Bus Stop, Lyon (France) at 12/27/2025 3:05:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/27/2025 8:00:00 PM. 50 Economy ticket for $71 per person are available. Travel duration is 16h 55m
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BlaBlaCar Bus16h 55m03:05 AMLyonPerrache Train Station8:00 PMPragueÚAN Florenc0EconomyA Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 12/27/2025 3:05:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/27/2025 8:00:00 PM. 50 Economy ticket for $71 per person are available. Travel duration is 16h 55m
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FlixBus16h 55m09:00 PMLyonPerrache Bus Stop1:55 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/27/2025 9:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/28/2025 1:55:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 16h 55m
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FlixBus17h 5m09:00 PMLyonPerrache Bus Stop2:05 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/27/2025 9:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/28/2025 2:05:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 17h 5m
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FlixBus17h 45m05:05 PMLyonPerrache Bus Stop10:50 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/27/2025 5:05:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/28/2025 10:50:00 AM. 50 Economy ticket for $105 per person are available. Travel duration is 17h 45m
Fastest Buses Saturday
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Volotea1h 40m06:15 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station7:55 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Volotea goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/28/2025 6:15:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/28/2025 7:55:00 AM. 50 Economy ticket for $73 per person are available. Travel duration is 1h 40m
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EasyJet Airline1h 40m05:45 PMLyons St. Exupery AirportLyons St. Exupery Airport7:25 PMPrague AirportPrague Airport0EconomyA Flight from EasyJet Airline goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 12/28/2025 5:45:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 12/28/2025 7:25:00 PM. 50 Economy ticket for $147 per person are available. Travel duration is 1h 40m
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Skyscanner1h 40m05:45 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station7:25 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Skyscanner goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/28/2025 5:45:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/28/2025 7:25:00 PM. 50 Economy ticket for $186 per person are available. Travel duration is 1h 40m
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LOT Polish Airlines / Polskie Linie Lotnicze13h 35m07:15 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station8:50 AMPrague AirportPrague Airport - T1/20EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/28/2025 7:15:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/29/2025 8:50:00 AM. 50 Economy ticket for $193 per person are available. Travel duration is 13h 35m
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Vueling Airlines18h 5m011:20 PMLyons St. Exupery AirportLyons St. Exupery Airport5:25 PMPrague AirportPrague Airport0EconomyA Flight from Vueling Airlines goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 12/28/2025 11:20:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 12/29/2025 5:25:00 PM. 50 Economy ticket for $208 per person are available. Travel duration is 18h 5m
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BlaBlaCar Bus16h 55m03:05 AMLyonPerrache Bus Stop8:00 PMPragueÚAN Florenc0EconomyA Bus from BlaBlaCar Bus goes from Perrache Bus Stop, Lyon (France) at 12/28/2025 3:05:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/28/2025 8:00:00 PM. 50 Economy ticket for $71 per person are available. Travel duration is 16h 55m
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BlaBlaCar Bus16h 55m03:05 AMLyonPerrache Train Station8:00 PMPragueÚAN Florenc0EconomyA Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 12/28/2025 3:05:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/28/2025 8:00:00 PM. 50 Economy ticket for $82 per person are available. Travel duration is 16h 55m
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FlixBus17h 25m010:00 PMLyonPerrache Bus Stop3:25 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/28/2025 10:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/29/2025 3:25:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 17h 25m
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FlixBus17h 45m05:05 PMLyonPerrache Bus Stop10:50 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/28/2025 5:05:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/29/2025 10:50:00 AM. 50 Economy ticket for $105 per person are available. Travel duration is 17h 45m
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FlixBus19h 0m03:15 AMLyonPerrache Bus Stop10:15 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/28/2025 3:15:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/28/2025 10:15:00 PM. 50 Economy ticket for $104 per person are available. Travel duration is 19h 0m
Fastest Flights Sunday
Fastest Buses Sunday
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EasyJet Airline1h 40m011:40 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station1:20 PMPrague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/29/2025 11:40:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/29/2025 1:20:00 PM. 50 Economy ticket for $157 per person are available. Travel duration is 1h 40m
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Volotea1h 40m09:55 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station11:35 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Volotea goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/29/2025 9:55:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/29/2025 11:35:00 AM. 50 Economy ticket for $174 per person are available. Travel duration is 1h 40m
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Lufthansa CityLine4h 0m06:25 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station10:25 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Lufthansa CityLine goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/29/2025 6:25:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/29/2025 10:25:00 PM. 50 Economy ticket for $240 per person are available. Travel duration is 4h 0m
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LOT Polish Airlines / Polskie Linie Lotnicze7h 40m011:10 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station6:50 PMPrague AirportPrague Airport - T1/20EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/29/2025 11:10:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/29/2025 6:50:00 PM. 50 Economy ticket for $203 per person are available. Travel duration is 7h 40m
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LC Perú13h 30m08:35 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station10:05 PMPrague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/29/2025 8:35:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/29/2025 10:05:00 PM. 50 Economy ticket for $135 per person are available. Travel duration is 13h 30m
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FlixBus17h 45m05:05 PMLyonPerrache Bus Stop10:50 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/29/2025 5:05:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/30/2025 10:50:00 AM. 50 Economy ticket for $93 per person are available. Travel duration is 17h 45m
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FlixBus19h 0m03:15 AMLyonPerrache Bus Stop10:15 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/29/2025 3:15:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/29/2025 10:15:00 PM. 50 Economy ticket for $94 per person are available. Travel duration is 19h 0m
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FlixBus19h 5m05:20 AMLyonPerrache Bus Stop12:25 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/29/2025 5:20:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/30/2025 12:25:00 AM. 50 Economy ticket for $96 per person are available. Travel duration is 19h 5m
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FlixBus20h 30m09:30 AMLyonPerrache Bus Stop6:00 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/29/2025 9:30:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/30/2025 6:00:00 AM. 50 Economy ticket for $94 per person are available. Travel duration is 20h 30m
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FlixBus20h 45m09:30 AMLyonPerrache Bus Stop6:15 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/29/2025 9:30:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/30/2025 6:15:00 AM. 50 Economy ticket for $94 per person are available. Travel duration is 20h 45m
Fastest Flights Monday
Fastest Buses Monday
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Volotea1h 40m06:30 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station8:10 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Volotea goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/30/2025 6:30:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/30/2025 8:10:00 AM. 50 Economy ticket for $84 per person are available. Travel duration is 1h 40m
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LOT Polish Airlines / Polskie Linie Lotnicze7h 40m011:10 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station6:50 PMPrague AirportPrague Airport - T1/20EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/30/2025 11:10:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/30/2025 6:50:00 PM. 50 Economy ticket for $193 per person are available. Travel duration is 7h 40m
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Wizz Air17h 50m010:45 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station4:35 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Wizz Air goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/30/2025 10:45:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/31/2025 4:35:00 PM. 50 Economy ticket for $104 per person are available. Travel duration is 17h 50m
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LC Perú24h 30m09:30 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station10:00 PMPrague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/30/2025 9:30:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/31/2025 10:00:00 PM. 50 Economy ticket for $96 per person are available. Travel duration is 24h 30m
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EasyJet Airline25h 25m07:00 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station8:25 AMPrague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/30/2025 7:00:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/31/2025 8:25:00 AM. 50 Economy ticket for $109 per person are available. Travel duration is 25h 25m
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FlixBus17h 35m05:20 AMLyonPerrache Bus Stop10:55 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/30/2025 5:20:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 12/30/2025 10:55:00 PM. 50 Economy ticket for $96 per person are available. Travel duration is 17h 35m
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FlixBus17h 45m05:05 PMLyonPerrache Bus Stop10:50 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/30/2025 5:05:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/31/2025 10:50:00 AM. 50 Economy ticket for $96 per person are available. Travel duration is 17h 45m
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FlixBus18h 45m03:30 AMLyonPerrache Bus Stop10:15 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/30/2025 3:30:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/30/2025 10:15:00 PM. 50 Economy ticket for $98 per person are available. Travel duration is 18h 45m
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FlixBus19h 5m05:20 AMLyonPerrache Bus Stop12:25 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/30/2025 5:20:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/31/2025 12:25:00 AM. 50 Economy ticket for $97 per person are available. Travel duration is 19h 5m
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FlixBus19h 45m01:25 AMLyonPerrache Bus Stop9:10 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/30/2025 1:25:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 12/30/2025 9:10:00 PM. 50 Economy ticket for $101 per person are available. Travel duration is 19h 45m
Fastest Flights Tuesday
Fastest Buses Tuesday
Here you will find all operators and timetables for a
Bus from Lyon to Prague
What are the most popular stations in Lyon and Prague?
In Lyon, you will usually depart from Perrache Bus Stop, Part-Dieu Train Station or Perrache Train Station, while in Prague you will be arriving at Wilsonova Bus Station, ÚAN Florenc or Černý Most, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Prague from Lyon? With 9 connections between 2 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Lyon and Prague, you can pay as low as $71 with a Bus from BlaBlaCar Bus.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from Volotea: you will get to Prague in just 1h 40m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Lyon and Prague are FlixBus, Volotea and EasyJet Airline, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Lyon and Prague is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Caluire-et-Cuire or to Horoměřice, and look at flights from Lyons St. Exupery Airport, and landing at Prague Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Lyon to Prague?
The most popular companies between Lyon and Prague, are FlixBus, Volotea and EasyJet Airline. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus and BlaBlaCar Bus
Airlines: Volotea, EasyJet Airline, LOT Polish Airlines / Polskie Linie Lotnicze and 8 more.
All you need to know when you travel from Lyon to Prague
Check all information on comfort and services on all modes of transports from Lyon to Prague. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Lyon to Prague
How can I reach Prague from Lyon?
Every day, there are on average 9 connections between Bus and Flight, with which you can get to Prague from Lyon.
How far is Prague from Lyon?
The distance between Lyon and Prague is 535.0 miles.
What is the most ecofriendly mode of transport between Lyon and Prague?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 23 kgs of CO2, a train 30 kgs, a car 146 kgs, and a flight 212 kgs.
What is the cheapest mode of transport from Lyon to Prague?
You can get to Prague with just $71 by taking a Bus from BlaBlaCar Bus.
What is the fastest way to get from Lyon to Prague?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Prague in just 1h 40m with a Flight from Volotea.
More routes to Lyon and to Prague
Looking for more options? Here you can see the most popular routes to Lyon and to Prague. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Lyon
- Alicante to Lyon
- Annecy to Lyon
- Avignon to Lyon
- Barcelona to Lyon
- Bologna to Lyon
- Bordeaux to Lyon
- Braga to Lyon
- Caen to Lyon
- Dijon to Lyon
- Dusseldorf to Lyon
- Geneva to Lyon
- Genoa to Lyon
- Lisbon to Lyon
- London to Lyon
- Marseille to Lyon
- Milan to Lyon
- Nice to Lyon
- Paris Orly Airport to Lyon
- Paris to Lyon
- Rome to Lyon
- San Sebastian to Lyon
- Toulouse to Lyon
- Turin to Lyon
- Valencia to Lyon
- Trips to Prague
- Amsterdam to Prague
- Berlin to Prague
- Brno to Prague
- Budapest to Prague
- Dresden to Prague
- Florence to Prague
- Karlovy Vary to Prague
- Katowice to Prague
- Krakow to Prague
- Limburg an der Lahn to Prague
- Linz to Prague
- London to Prague
- Milan to Prague
- Minsk to Prague
- Munich to Prague
- Nuremberg to Prague
- Paris to Prague
- Prague Airport to Prague
- Presov to Prague
- Rimavska Sobota to Prague
- Tabor to Prague
- Třebíč to Prague
- Vienna to Prague
- Zurich to Prague
