What is the best way to travel from Lyon to Prague?
Looking for a trip? Compare all the available Flights and Buses for the journey to Prague from Lyon. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 3 available companies to find your perfect trip!
What is the cheapest way to reach Prague from Lyon?
You can get to Prague with just $56 by taking a Flight from Volotea, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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FlixBus17h 5m09:30 PMLyonLyon Avenue Tony Garnier Bus Stop2:35 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/24/2026 9:30:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 3/25/2026 2:35:00 PM. 50 Economy ticket for $71 per person are available. Travel duration is 17h 5m
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FlixBus17h 15m09:30 PMLyonLyon Avenue Tony Garnier Bus Stop2:45 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/24/2026 9:30:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 3/25/2026 2:45:00 PM. 50 Economy ticket for $71 per person are available. Travel duration is 17h 15m
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FlixBus22h 50m09:30 PMLyonLyon Avenue Tony Garnier Bus Stop8:20 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/24/2026 9:30:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 3/25/2026 8:20:00 PM. 50 Economy ticket for $74 per person are available. Travel duration is 22h 50m
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FlixBus20h 15m01:05 PMLyonLyon Avenue Tony Garnier Bus Stop9:20 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/24/2026 1:05:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 3/25/2026 9:20:00 AM. 50 Economy ticket for $74 per person are available. Travel duration is 20h 15m
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FlixBus23h 35m01:05 PMLyonLyon Avenue Tony Garnier Bus Stop12:40 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/24/2026 1:05:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 3/25/2026 12:40:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 23h 35m
Cheapest Buses Tuesday
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FlixBus25h 30m09:25 PMLyonLyon Avenue Tony Garnier Bus Stop10:55 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/25/2026 9:25:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 3/26/2026 10:55:00 PM. 50 Economy ticket for $61 per person are available. Travel duration is 25h 30m
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FlixBus24h 45m010:45 AMLyonLyon Avenue Tony Garnier Bus Stop11:30 AMPragueZličín0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/25/2026 10:45:00 AM to Zličín, Prague (Czech Republic) arriving at 3/26/2026 11:30:00 AM. 50 Economy ticket for $61 per person are available. Travel duration is 24h 45m
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FlixBus26h 55m08:35 AMLyonLyon Avenue Tony Garnier Bus Stop11:30 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/25/2026 8:35:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 3/26/2026 11:30:00 AM. 50 Economy ticket for $69 per person are available. Travel duration is 26h 55m
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FlixBus23h 50m010:45 AMLyonLyon Avenue Tony Garnier Bus Stop10:35 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/25/2026 10:45:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 3/26/2026 10:35:00 AM. 50 Economy ticket for $71 per person are available. Travel duration is 23h 50m
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FlixBus20h 30m02:25 AMLyonLyon Avenue Tony Garnier Bus Stop10:55 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/25/2026 2:25:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 3/25/2026 10:55:00 PM. 50 Economy ticket for $73 per person are available. Travel duration is 20h 30m
Cheapest Buses Wednesday
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FlixBus17h 25m010:00 PMLyonLyon Avenue Tony Garnier Bus Stop3:25 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/26/2026 10:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 3/27/2026 3:25:00 PM. 50 Economy ticket for $74 per person are available. Travel duration is 17h 25m
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FlixBus18h 10m010:00 PMLyonLyon Avenue Tony Garnier Bus Stop4:10 PMPragueČerný Most0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/26/2026 10:00:00 PM to Černý Most, Prague (Czech Republic) arriving at 3/27/2026 4:10:00 PM. 50 Economy ticket for $74 per person are available. Travel duration is 18h 10m
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FlixBus20h 30m02:25 AMLyonLyon Avenue Tony Garnier Bus Stop10:55 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/26/2026 2:25:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 3/26/2026 10:55:00 PM. 50 Economy ticket for $82 per person are available. Travel duration is 20h 30m
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FlixBus19h 55m02:25 AMLyonLyon Avenue Tony Garnier Bus Stop10:20 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/26/2026 2:25:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 3/26/2026 10:20:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 19h 55m
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FlixBus15h 5m06:15 PMLyonLyon Avenue Tony Garnier Bus Stop9:20 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/26/2026 6:15:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 3/27/2026 9:20:00 AM. 50 Economy ticket for $97 per person are available. Travel duration is 15h 5m
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EasyJet Airline1h 40m01:45 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station3:25 PMPrague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 3/26/2026 1:45:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 3/26/2026 3:25:00 PM. 50 Economy ticket for $85 per person are available. Travel duration is 1h 40m
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LC Perú24h 30m09:30 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station10:00 PMPrague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 3/26/2026 9:30:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 3/27/2026 10:00:00 PM. 50 Economy ticket for $89 per person are available. Travel duration is 24h 30m
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Austrian Airlines3h 10m012:50 PMLyons St. Exupery AirportLyons St. Exupery Airport4:00 PMPrague AirportPrague Airport0EconomyA Flight from Austrian Airlines goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 3/26/2026 12:50:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 3/26/2026 4:00:00 PM. 50 Economy ticket for $163 per person are available. Travel duration is 3h 10m
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Lufthansa7h 30m02:55 PMLyons St. Exupery AirportLyons St. Exupery Airport10:25 PMPrague AirportPrague Airport0EconomyA Flight from Lufthansa goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 3/26/2026 2:55:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 3/26/2026 10:25:00 PM. 50 Economy ticket for $196 per person are available. Travel duration is 7h 30m
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Brussels Airlines13h 55m07:00 AMLyons St. Exupery AirportLyons St. Exupery Airport8:55 PMPrague AirportPrague Airport0EconomyA Flight from Brussels Airlines goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 3/26/2026 7:00:00 AM to Prague Airport, Prague Airport (Czech Republic) arriving at 3/26/2026 8:55:00 PM. 50 Economy ticket for $196 per person are available. Travel duration is 13h 55m
Cheapest Buses Thursday
Cheapest Flights Thursday
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BlaBlaCar Bus21h 45m012:00 PMLyonPerrache Train Station9:45 AMPragueÚAN Florenc0EconomyA Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 3/27/2026 12:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 3/28/2026 9:45:00 AM. 50 Economy ticket for $68 per person are available. Travel duration is 21h 45m
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FlixBus14h 40m06:15 PMLyonLyon Avenue Tony Garnier Bus Stop8:55 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/27/2026 6:15:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 3/28/2026 8:55:00 AM. 50 Economy ticket for $74 per person are available. Travel duration is 14h 40m
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FlixBus15h 5m06:15 PMLyonLyon Avenue Tony Garnier Bus Stop9:20 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/27/2026 6:15:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 3/28/2026 9:20:00 AM. 50 Economy ticket for $74 per person are available. Travel duration is 15h 5m
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FlixBus17h 5m09:30 PMLyonLyon Avenue Tony Garnier Bus Stop2:35 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/27/2026 9:30:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 3/28/2026 2:35:00 PM. 50 Economy ticket for $81 per person are available. Travel duration is 17h 5m
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Volotea1h 40m07:30 AMLyons St. Exupery AirportLyons St. Exupery Airport9:10 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Volotea goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 3/27/2026 7:30:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 3/27/2026 9:10:00 AM. 50 Economy ticket for $108 per person are available. Travel duration is 1h 40m
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EasyJet Airline1h 40m02:15 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station3:55 PMPrague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 3/27/2026 2:15:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 3/27/2026 3:55:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 1h 40m
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LC Perú12h 0m010:05 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station10:05 PMPrague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 3/27/2026 10:05:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 3/27/2026 10:05:00 PM. 50 Economy ticket for $144 per person are available. Travel duration is 12h 0m
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LOT Polish Airlines / Polskie Linie Lotnicze22h 0m07:15 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station5:15 PMPrague AirportPrague Airport - T1/20EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 3/27/2026 7:15:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 3/28/2026 5:15:00 PM. 50 Economy ticket for $183 per person are available. Travel duration is 22h 0m
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Austrian Airlines3h 10m012:50 PMLyons St. Exupery AirportLyons St. Exupery Airport4:00 PMPrague AirportPrague Airport0EconomyA Flight from Austrian Airlines goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 3/27/2026 12:50:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 3/27/2026 4:00:00 PM. 50 Economy ticket for $185 per person are available. Travel duration is 3h 10m
Cheapest Buses Friday
Cheapest Flights Friday
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FlixBus18h 45m03:30 AMLyonLyon Avenue Tony Garnier Bus Stop10:15 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/28/2026 3:30:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 3/28/2026 10:15:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 18h 45m
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FlixBus17h 5m09:30 PMLyonLyon Avenue Tony Garnier Bus Stop3:35 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/28/2026 9:30:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 3/29/2026 3:35:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 17h 5m
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FlixBus17h 15m09:30 PMLyonLyon Avenue Tony Garnier Bus Stop3:45 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/28/2026 9:30:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 3/29/2026 3:45:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 17h 15m
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FlixBus17h 25m010:00 PMLyonLyon Avenue Tony Garnier Bus Stop4:25 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/28/2026 10:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 3/29/2026 4:25:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 17h 25m
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FlixBus18h 10m010:00 PMLyonLyon Avenue Tony Garnier Bus Stop5:10 PMPragueČerný Most0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/28/2026 10:00:00 PM to Černý Most, Prague (Czech Republic) arriving at 3/29/2026 5:10:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 18h 10m
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AJet19h 5m02:50 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station10:55 AMPrague AirportPrague Airport - T1/20EconomyA Flight from AJet goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 3/28/2026 2:50:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 3/29/2026 10:55:00 AM. 50 Economy ticket for $134 per person are available. Travel duration is 19h 5m
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EasyJet Airline8h 35m08:00 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station4:35 PMPrague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 3/28/2026 8:00:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 3/28/2026 4:35:00 PM. 50 Economy ticket for $177 per person are available. Travel duration is 8h 35m
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Pegasus Group LTD29h 15m012:45 PMLyons St. Exupery AirportLyons St. Exupery Airport7:00 PMPrague AirportPrague Airport0EconomyA Flight from Pegasus Group LTD goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 3/28/2026 12:45:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 3/29/2026 7:00:00 PM. 50 Economy ticket for $188 per person are available. Travel duration is 29h 15m
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Lufthansa11h 35m010:50 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station10:25 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Lufthansa goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 3/28/2026 10:50:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 3/28/2026 10:25:00 PM. 50 Economy ticket for $256 per person are available. Travel duration is 11h 35m
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Austrian Airlines9h 50m012:50 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station10:40 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Austrian Airlines goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 3/28/2026 12:50:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 3/28/2026 10:40:00 PM. 50 Economy ticket for $261 per person are available. Travel duration is 9h 50m
Cheapest Buses Saturday
Cheapest Flights Saturday
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Volotea14h 20m07:05 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station9:25 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Volotea goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 3/29/2026 7:05:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 3/30/2026 9:25:00 AM. 50 Economy ticket for $56 per person are available. Travel duration is 14h 20m
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EasyJet Airline11h 25m07:05 AMLyons St. Exupery AirportLyons St. Exupery Airport6:30 PMPrague AirportPrague Airport0EconomyA Flight from EasyJet Airline goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 3/29/2026 7:05:00 AM to Prague Airport, Prague Airport (Czech Republic) arriving at 3/29/2026 6:30:00 PM. 50 Economy ticket for $103 per person are available. Travel duration is 11h 25m
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Skyscanner1h 40m07:35 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station9:15 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Skyscanner goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 3/29/2026 7:35:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 3/29/2026 9:15:00 PM. 50 Economy ticket for $142 per person are available. Travel duration is 1h 40m
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LOT Polish Airlines / Polskie Linie Lotnicze13h 55m07:20 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station9:15 AMPrague AirportPrague Airport - T1/20EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 3/29/2026 7:20:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 3/30/2026 9:15:00 AM. 50 Economy ticket for $143 per person are available. Travel duration is 13h 55m
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Brussels Airlines7h 15m01:10 PMLyons St. Exupery AirportLyons St. Exupery Airport8:25 PMPrague AirportPrague Airport0EconomyA Flight from Brussels Airlines goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 3/29/2026 1:10:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 3/29/2026 8:25:00 PM. 50 Economy ticket for $163 per person are available. Travel duration is 7h 15m
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FlixBus17h 5m09:30 PMLyonLyon Avenue Tony Garnier Bus Stop2:35 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/29/2026 9:30:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 3/30/2026 2:35:00 PM. 50 Economy ticket for $74 per person are available. Travel duration is 17h 5m
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FlixBus14h 40m06:15 PMLyonLyon Avenue Tony Garnier Bus Stop8:55 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/29/2026 6:15:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 3/30/2026 8:55:00 AM. 50 Economy ticket for $74 per person are available. Travel duration is 14h 40m
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FlixBus15h 5m06:15 PMLyonLyon Avenue Tony Garnier Bus Stop9:20 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/29/2026 6:15:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 3/30/2026 9:20:00 AM. 50 Economy ticket for $74 per person are available. Travel duration is 15h 5m
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STARSHIPPER SAS21h 55m04:40 PMLyons St. Exupery AirportLyons St. Exupery Airport2:35 PMPragueWilsonova Bus Station0EconomyA Bus from STARSHIPPER SAS goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 3/29/2026 4:40:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 3/30/2026 2:35:00 PM. 50 Economy ticket for $106 per person are available. Travel duration is 21h 55m
Cheapest Flights Sunday
Cheapest Buses Sunday
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FlixBus19h 5m05:20 AMLyonLyon Avenue Tony Garnier Bus Stop12:25 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/30/2026 5:20:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 3/31/2026 12:25:00 AM. 50 Economy ticket for $61 per person are available. Travel duration is 19h 5m
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FlixBus19h 0m03:15 AMLyonLyon Avenue Tony Garnier Bus Stop10:15 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/30/2026 3:15:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 3/30/2026 10:15:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 19h 0m
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FlixBus17h 35m05:20 AMLyonLyon Avenue Tony Garnier Bus Stop10:55 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/30/2026 5:20:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 3/30/2026 10:55:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 17h 35m
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BlaBlaCar Bus21h 45m012:00 PMLyonPerrache Train Station9:45 AMPragueÚAN Florenc0EconomyA Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 3/30/2026 12:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 3/31/2026 9:45:00 AM. 50 Economy ticket for $77 per person are available. Travel duration is 21h 45m
Cheapest Buses Monday
What are the fastest trips from Lyon to Prague?
You can get to Prague from Lyon in just 1h 40m with a Flight from EasyJet Airline. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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FlixBus17h 5m09:30 PMLyonLyon Avenue Tony Garnier Bus Stop2:35 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/24/2026 9:30:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 3/25/2026 2:35:00 PM. 50 Economy ticket for $71 per person are available. Travel duration is 17h 5m
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FlixBus17h 15m09:30 PMLyonLyon Avenue Tony Garnier Bus Stop2:45 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/24/2026 9:30:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 3/25/2026 2:45:00 PM. 50 Economy ticket for $71 per person are available. Travel duration is 17h 15m
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FlixBus20h 15m01:05 PMLyonLyon Avenue Tony Garnier Bus Stop9:20 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/24/2026 1:05:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 3/25/2026 9:20:00 AM. 50 Economy ticket for $74 per person are available. Travel duration is 20h 15m
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FlixBus22h 50m09:30 PMLyonLyon Avenue Tony Garnier Bus Stop8:20 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/24/2026 9:30:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 3/25/2026 8:20:00 PM. 50 Economy ticket for $74 per person are available. Travel duration is 22h 50m
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FlixBus23h 35m01:05 PMLyonLyon Avenue Tony Garnier Bus Stop12:40 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/24/2026 1:05:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 3/25/2026 12:40:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 23h 35m
Fastest Buses Tuesday
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FlixBus20h 30m02:25 AMLyonLyon Avenue Tony Garnier Bus Stop10:55 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/25/2026 2:25:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 3/25/2026 10:55:00 PM. 50 Economy ticket for $73 per person are available. Travel duration is 20h 30m
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FlixBus23h 50m010:45 AMLyonLyon Avenue Tony Garnier Bus Stop10:35 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/25/2026 10:45:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 3/26/2026 10:35:00 AM. 50 Economy ticket for $71 per person are available. Travel duration is 23h 50m
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FlixBus24h 45m010:45 AMLyonLyon Avenue Tony Garnier Bus Stop11:30 AMPragueZličín0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/25/2026 10:45:00 AM to Zličín, Prague (Czech Republic) arriving at 3/26/2026 11:30:00 AM. 50 Economy ticket for $61 per person are available. Travel duration is 24h 45m
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FlixBus25h 30m09:25 PMLyonLyon Avenue Tony Garnier Bus Stop10:55 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/25/2026 9:25:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 3/26/2026 10:55:00 PM. 50 Economy ticket for $61 per person are available. Travel duration is 25h 30m
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FlixBus26h 55m08:35 AMLyonLyon Avenue Tony Garnier Bus Stop11:30 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/25/2026 8:35:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 3/26/2026 11:30:00 AM. 50 Economy ticket for $69 per person are available. Travel duration is 26h 55m
Fastest Buses Wednesday
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EasyJet Airline1h 40m01:45 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station3:25 PMPrague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 3/26/2026 1:45:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 3/26/2026 3:25:00 PM. 50 Economy ticket for $85 per person are available. Travel duration is 1h 40m
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Austrian Airlines3h 10m012:50 PMLyons St. Exupery AirportLyons St. Exupery Airport4:00 PMPrague AirportPrague Airport0EconomyA Flight from Austrian Airlines goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 3/26/2026 12:50:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 3/26/2026 4:00:00 PM. 50 Economy ticket for $163 per person are available. Travel duration is 3h 10m
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Lufthansa7h 30m02:55 PMLyons St. Exupery AirportLyons St. Exupery Airport10:25 PMPrague AirportPrague Airport0EconomyA Flight from Lufthansa goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 3/26/2026 2:55:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 3/26/2026 10:25:00 PM. 50 Economy ticket for $196 per person are available. Travel duration is 7h 30m
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Brussels Airlines13h 55m07:00 AMLyons St. Exupery AirportLyons St. Exupery Airport8:55 PMPrague AirportPrague Airport0EconomyA Flight from Brussels Airlines goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 3/26/2026 7:00:00 AM to Prague Airport, Prague Airport (Czech Republic) arriving at 3/26/2026 8:55:00 PM. 50 Economy ticket for $196 per person are available. Travel duration is 13h 55m
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LC Perú24h 30m09:30 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station10:00 PMPrague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 3/26/2026 9:30:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 3/27/2026 10:00:00 PM. 50 Economy ticket for $89 per person are available. Travel duration is 24h 30m
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FlixBus15h 5m06:15 PMLyonLyon Avenue Tony Garnier Bus Stop9:20 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/26/2026 6:15:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 3/27/2026 9:20:00 AM. 50 Economy ticket for $97 per person are available. Travel duration is 15h 5m
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FlixBus17h 25m010:00 PMLyonLyon Avenue Tony Garnier Bus Stop3:25 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/26/2026 10:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 3/27/2026 3:25:00 PM. 50 Economy ticket for $74 per person are available. Travel duration is 17h 25m
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FlixBus18h 10m010:00 PMLyonLyon Avenue Tony Garnier Bus Stop4:10 PMPragueČerný Most0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/26/2026 10:00:00 PM to Černý Most, Prague (Czech Republic) arriving at 3/27/2026 4:10:00 PM. 50 Economy ticket for $74 per person are available. Travel duration is 18h 10m
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FlixBus19h 55m02:25 AMLyonLyon Avenue Tony Garnier Bus Stop10:20 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/26/2026 2:25:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 3/26/2026 10:20:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 19h 55m
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FlixBus20h 30m02:25 AMLyonLyon Avenue Tony Garnier Bus Stop10:55 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/26/2026 2:25:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 3/26/2026 10:55:00 PM. 50 Economy ticket for $82 per person are available. Travel duration is 20h 30m
Fastest Flights Thursday
Fastest Buses Thursday
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Volotea1h 40m07:30 AMLyons St. Exupery AirportLyons St. Exupery Airport9:10 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Volotea goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 3/27/2026 7:30:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 3/27/2026 9:10:00 AM. 50 Economy ticket for $108 per person are available. Travel duration is 1h 40m
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EasyJet Airline1h 40m02:15 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station3:55 PMPrague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 3/27/2026 2:15:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 3/27/2026 3:55:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 1h 40m
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Austrian Airlines3h 10m012:50 PMLyons St. Exupery AirportLyons St. Exupery Airport4:00 PMPrague AirportPrague Airport0EconomyA Flight from Austrian Airlines goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 3/27/2026 12:50:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 3/27/2026 4:00:00 PM. 50 Economy ticket for $185 per person are available. Travel duration is 3h 10m
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LC Perú12h 0m010:05 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station10:05 PMPrague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 3/27/2026 10:05:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 3/27/2026 10:05:00 PM. 50 Economy ticket for $144 per person are available. Travel duration is 12h 0m
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LOT Polish Airlines / Polskie Linie Lotnicze22h 0m07:15 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station5:15 PMPrague AirportPrague Airport - T1/20EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 3/27/2026 7:15:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 3/28/2026 5:15:00 PM. 50 Economy ticket for $183 per person are available. Travel duration is 22h 0m
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FlixBus14h 40m06:15 PMLyonLyon Avenue Tony Garnier Bus Stop8:55 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/27/2026 6:15:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 3/28/2026 8:55:00 AM. 50 Economy ticket for $74 per person are available. Travel duration is 14h 40m
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FlixBus15h 5m06:15 PMLyonLyon Avenue Tony Garnier Bus Stop9:20 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/27/2026 6:15:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 3/28/2026 9:20:00 AM. 50 Economy ticket for $74 per person are available. Travel duration is 15h 5m
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FlixBus17h 5m09:30 PMLyonLyon Avenue Tony Garnier Bus Stop2:35 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/27/2026 9:30:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 3/28/2026 2:35:00 PM. 50 Economy ticket for $81 per person are available. Travel duration is 17h 5m
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BlaBlaCar Bus21h 45m012:00 PMLyonPerrache Train Station9:45 AMPragueÚAN Florenc0EconomyA Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 3/27/2026 12:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 3/28/2026 9:45:00 AM. 50 Economy ticket for $68 per person are available. Travel duration is 21h 45m
Fastest Flights Friday
Fastest Buses Friday
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EasyJet Airline8h 35m08:00 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station4:35 PMPrague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 3/28/2026 8:00:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 3/28/2026 4:35:00 PM. 50 Economy ticket for $177 per person are available. Travel duration is 8h 35m
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Austrian Airlines9h 50m012:50 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station10:40 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Austrian Airlines goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 3/28/2026 12:50:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 3/28/2026 10:40:00 PM. 50 Economy ticket for $261 per person are available. Travel duration is 9h 50m
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Lufthansa11h 35m010:50 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station10:25 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Lufthansa goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 3/28/2026 10:50:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 3/28/2026 10:25:00 PM. 50 Economy ticket for $256 per person are available. Travel duration is 11h 35m
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AJet19h 5m02:50 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station10:55 AMPrague AirportPrague Airport - T1/20EconomyA Flight from AJet goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 3/28/2026 2:50:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 3/29/2026 10:55:00 AM. 50 Economy ticket for $134 per person are available. Travel duration is 19h 5m
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Pegasus Group LTD29h 15m012:45 PMLyons St. Exupery AirportLyons St. Exupery Airport7:00 PMPrague AirportPrague Airport0EconomyA Flight from Pegasus Group LTD goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 3/28/2026 12:45:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 3/29/2026 7:00:00 PM. 50 Economy ticket for $188 per person are available. Travel duration is 29h 15m
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FlixBus17h 5m09:30 PMLyonLyon Avenue Tony Garnier Bus Stop3:35 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/28/2026 9:30:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 3/29/2026 3:35:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 17h 5m
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FlixBus17h 15m09:30 PMLyonLyon Avenue Tony Garnier Bus Stop3:45 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/28/2026 9:30:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 3/29/2026 3:45:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 17h 15m
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FlixBus17h 25m010:00 PMLyonLyon Avenue Tony Garnier Bus Stop4:25 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/28/2026 10:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 3/29/2026 4:25:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 17h 25m
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FlixBus18h 10m010:00 PMLyonLyon Avenue Tony Garnier Bus Stop5:10 PMPragueČerný Most0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/28/2026 10:00:00 PM to Černý Most, Prague (Czech Republic) arriving at 3/29/2026 5:10:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 18h 10m
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FlixBus18h 45m03:30 AMLyonLyon Avenue Tony Garnier Bus Stop10:15 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/28/2026 3:30:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 3/28/2026 10:15:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 18h 45m
Fastest Flights Saturday
Fastest Buses Saturday
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Skyscanner1h 40m07:35 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station9:15 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Skyscanner goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 3/29/2026 7:35:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 3/29/2026 9:15:00 PM. 50 Economy ticket for $142 per person are available. Travel duration is 1h 40m
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Brussels Airlines7h 15m01:10 PMLyons St. Exupery AirportLyons St. Exupery Airport8:25 PMPrague AirportPrague Airport0EconomyA Flight from Brussels Airlines goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 3/29/2026 1:10:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 3/29/2026 8:25:00 PM. 50 Economy ticket for $163 per person are available. Travel duration is 7h 15m
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EasyJet Airline11h 25m07:05 AMLyons St. Exupery AirportLyons St. Exupery Airport6:30 PMPrague AirportPrague Airport0EconomyA Flight from EasyJet Airline goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 3/29/2026 7:05:00 AM to Prague Airport, Prague Airport (Czech Republic) arriving at 3/29/2026 6:30:00 PM. 50 Economy ticket for $103 per person are available. Travel duration is 11h 25m
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LOT Polish Airlines / Polskie Linie Lotnicze13h 55m07:20 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station9:15 AMPrague AirportPrague Airport - T1/20EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 3/29/2026 7:20:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 3/30/2026 9:15:00 AM. 50 Economy ticket for $143 per person are available. Travel duration is 13h 55m
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Volotea14h 20m07:05 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station9:25 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Volotea goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 3/29/2026 7:05:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 3/30/2026 9:25:00 AM. 50 Economy ticket for $56 per person are available. Travel duration is 14h 20m
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FlixBus14h 40m06:15 PMLyonLyon Avenue Tony Garnier Bus Stop8:55 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/29/2026 6:15:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 3/30/2026 8:55:00 AM. 50 Economy ticket for $74 per person are available. Travel duration is 14h 40m
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FlixBus15h 5m06:15 PMLyonLyon Avenue Tony Garnier Bus Stop9:20 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/29/2026 6:15:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 3/30/2026 9:20:00 AM. 50 Economy ticket for $74 per person are available. Travel duration is 15h 5m
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FlixBus17h 5m09:30 PMLyonLyon Avenue Tony Garnier Bus Stop2:35 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/29/2026 9:30:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 3/30/2026 2:35:00 PM. 50 Economy ticket for $74 per person are available. Travel duration is 17h 5m
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STARSHIPPER SAS21h 55m04:40 PMLyons St. Exupery AirportLyons St. Exupery Airport2:35 PMPragueWilsonova Bus Station0EconomyA Bus from STARSHIPPER SAS goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 3/29/2026 4:40:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 3/30/2026 2:35:00 PM. 50 Economy ticket for $106 per person are available. Travel duration is 21h 55m
Fastest Flights Sunday
Fastest Buses Sunday
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FlixBus17h 35m05:20 AMLyonLyon Avenue Tony Garnier Bus Stop10:55 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/30/2026 5:20:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 3/30/2026 10:55:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 17h 35m
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FlixBus19h 0m03:15 AMLyonLyon Avenue Tony Garnier Bus Stop10:15 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/30/2026 3:15:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 3/30/2026 10:15:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 19h 0m
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FlixBus19h 5m05:20 AMLyonLyon Avenue Tony Garnier Bus Stop12:25 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 3/30/2026 5:20:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 3/31/2026 12:25:00 AM. 50 Economy ticket for $61 per person are available. Travel duration is 19h 5m
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BlaBlaCar Bus21h 45m012:00 PMLyonPerrache Train Station9:45 AMPragueÚAN Florenc0EconomyA Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 3/30/2026 12:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 3/31/2026 9:45:00 AM. 50 Economy ticket for $77 per person are available. Travel duration is 21h 45m
Fastest Buses Monday
Here you will find all operators and timetables for a
Bus from Lyon to Prague
What are the most popular stations in Lyon and Prague?
In Lyon, you will usually depart from Perrache Bus Stop, Part-Dieu Train Station or Perrache Train Station, while in Prague you will be arriving at Wilsonova Bus Station, ÚAN Florenc or Černý Most, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Prague from Lyon? With 7 connections between 3 Flight and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Lyon and Prague, you can pay as low as $56 with a Flight from Volotea.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from EasyJet Airline: you will get to Prague in just 1h 40m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Lyon and Prague are FlixBus, EasyJet Airline and Austrian Airlines, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Lyon and Prague is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Caluire-et-Cuire or to Horoměřice, and look at flights from Lyons St. Exupery Airport, and landing at Prague Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Lyon to Prague?
The most popular companies between Lyon and Prague, are FlixBus, EasyJet Airline and Austrian Airlines. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus, BlaBlaCar Bus and STARSHIPPER SAS
Airlines: EasyJet Airline, Austrian Airlines, LC Perú and 7 more.
All you need to know when you travel from Lyon to Prague
Check all information on comfort and services on all modes of transports from Lyon to Prague. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Lyon to Prague
How can I reach Prague from Lyon?
Every day, there are on average 7 connections between Flight and Bus, with which you can get to Prague from Lyon.
How far is Prague from Lyon?
The distance between Lyon and Prague is 535.0 miles.
What is the most ecofriendly mode of transport between Lyon and Prague?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 23 kgs of CO2, a train 30 kgs, a car 146 kgs, and a flight 212 kgs.
What is the cheapest mode of transport from Lyon to Prague?
You can get to Prague with just $56 by taking a Flight from Volotea.
What is the fastest way to get from Lyon to Prague?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Prague in just 1h 40m with a Flight from EasyJet Airline.
More routes to Lyon and to Prague
Looking for more options? Here you can see the most popular routes to Lyon and to Prague. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Lyon
- Alicante to Lyon
- Annecy to Lyon
- Avignon to Lyon
- Barcelona to Lyon
- Basel to Lyon
- Bordeaux to Lyon
- Chambery to Lyon
- Dusseldorf to Lyon
- Geneva to Lyon
- Genoa to Lyon
- Grenoble to Lyon
- London to Lyon
- Madrid to Lyon
- Marseille to Lyon
- Milan to Lyon
- Nantes to Lyon
- Nice to Lyon
- Paris Orly Airport to Lyon
- Paris to Lyon
- Rome to Lyon
- Saint-Étienne to Lyon
- Toulouse to Lyon
- Turin to Lyon
- Valencia to Lyon
- Trips to Prague
- Amsterdam to Prague
- Belgrade to Prague
- Bratislava to Prague
- Brno to Prague
- Budapest to Prague
- Dresden to Prague
- Frankfurt am Main to Prague
- Hradec Kralove to Prague
- Istanbul to Prague
- Karlovy Vary to Prague
- Katowice to Prague
- Kornwestheim to Prague
- Krakow to Prague
- London to Prague
- Louny to Prague
- Memmingen to Prague
- Nuremberg to Prague
- Paris to Prague
- Pilsen to Prague
- Poznan to Prague
- Presov to Prague
- Teplice to Prague
- Zagreb to Prague
- Zurich to Prague
