What is the best way to travel from Lyon to Prague?
Looking for a trip? Compare all the available Buses and Flights for the journey to Prague from Lyon. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 3 available companies to find your perfect trip!
What is the cheapest way to reach Prague from Lyon?
You can get to Prague with just $62 by taking a Bus from BlaBlaCar Bus, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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Volotea1h 40m011:50 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station1:30 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Volotea goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/18/2025 11:50:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/18/2025 1:30:00 PM. 50 Economy ticket for $73 per person are available. Travel duration is 1h 40m
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EasyJet Airline10h 45m09:20 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station8:05 AMPrague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/18/2025 9:20:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/19/2025 8:05:00 AM. 50 Economy ticket for $125 per person are available. Travel duration is 10h 45m
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Skyscanner1h 40m01:45 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station3:25 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Skyscanner goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/18/2025 1:45:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/18/2025 3:25:00 PM. 50 Economy ticket for $156 per person are available. Travel duration is 1h 40m
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Brussels Airlines6h 5m011:50 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station5:55 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Brussels Airlines goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/18/2025 11:50:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/18/2025 5:55:00 PM. 50 Economy ticket for $210 per person are available. Travel duration is 6h 5m
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Austrian Airlines3h 10m012:50 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station4:00 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Austrian Airlines goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/18/2025 12:50:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/18/2025 4:00:00 PM. 50 Economy ticket for $211 per person are available. Travel duration is 3h 10m
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FlixBus14h 40m06:15 PMLyonPerrache Bus Stop8:55 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/18/2025 6:15:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 12/19/2025 8:55:00 AM. 50 Economy ticket for $112 per person are available. Travel duration is 14h 40m
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FlixBus15h 5m06:15 PMLyonPerrache Bus Stop9:20 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/18/2025 6:15:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/19/2025 9:20:00 AM. 50 Economy ticket for $112 per person are available. Travel duration is 15h 5m
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FlixBus17h 5m09:00 PMLyonPerrache Bus Stop2:05 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/18/2025 9:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/19/2025 2:05:00 PM. 50 Economy ticket for $122 per person are available. Travel duration is 17h 5m
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FlixBus16h 55m09:00 PMLyonPerrache Bus Stop1:55 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/18/2025 9:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/19/2025 1:55:00 PM. 50 Economy ticket for $122 per person are available. Travel duration is 16h 55m
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FlixBus18h 10m010:00 PMLyonPerrache Bus Stop4:10 PMPragueČerný Most0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/18/2025 10:00:00 PM to Černý Most, Prague (Czech Republic) arriving at 12/19/2025 4:10:00 PM. 50 Economy ticket for $126 per person are available. Travel duration is 18h 10m
Cheapest Flights Thursday
Cheapest Buses Thursday
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BlaBlaCar Bus16h 55m03:05 AMLyonPerrache Train Station8:00 PMPragueÚAN Florenc0EconomyA Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 12/19/2025 3:05:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/19/2025 8:00:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 16h 55m
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BlaBlaCar Bus16h 55m03:05 AMLyonPerrache Bus Stop8:00 PMPragueÚAN Florenc0EconomyA Bus from BlaBlaCar Bus goes from Perrache Bus Stop, Lyon (France) at 12/19/2025 3:05:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/19/2025 8:00:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 16h 55m
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FlixBus17h 35m05:20 AMLyonPerrache Bus Stop10:55 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/19/2025 5:20:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 12/19/2025 10:55:00 PM. 50 Economy ticket for $115 per person are available. Travel duration is 17h 35m
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FlixBus16h 30m05:20 AMLyonPerrache Bus Stop9:50 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/19/2025 5:20:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/19/2025 9:50:00 PM. 50 Economy ticket for $115 per person are available. Travel duration is 16h 30m
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STARSHIPPER SAS21h 15m04:40 PMLyons St. Exupery AirportLyons St. Exupery Airport1:55 PMPragueWilsonova Bus Station0EconomyA Bus from STARSHIPPER SAS goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 12/19/2025 4:40:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/20/2025 1:55:00 PM. 50 Economy ticket for $186 per person are available. Travel duration is 21h 15m
Cheapest Buses Friday
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RegioJet15h 55m02:35 PMLyonPerrache Bus Stop6:30 AMPragueÚAN Florenc0EconomyA Bus from RegioJet goes from Perrache Bus Stop, Lyon (France) at 12/20/2025 2:35:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/21/2025 6:30:00 AM. 50 Economy ticket for $106 per person are available. Travel duration is 15h 55m
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RegioJet15h 50m02:35 PMLyonPerrache Bus Stop6:25 AMPragueTrain station Wilsonova0EconomyA Bus from RegioJet goes from Perrache Bus Stop, Lyon (France) at 12/20/2025 2:35:00 PM to Train station Wilsonova, Prague (Czech Republic) arriving at 12/21/2025 6:25:00 AM. 50 Economy ticket for $106 per person are available. Travel duration is 15h 50m
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FlixBus14h 40m06:15 PMLyonPerrache Bus Stop8:55 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/20/2025 6:15:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 12/21/2025 8:55:00 AM. 50 Economy ticket for $122 per person are available. Travel duration is 14h 40m
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FlixBus15h 5m06:15 PMLyonPerrache Bus Stop9:20 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/20/2025 6:15:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/21/2025 9:20:00 AM. 50 Economy ticket for $122 per person are available. Travel duration is 15h 5m
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FlixBus17h 25m010:00 PMLyonPerrache Bus Stop3:25 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/20/2025 10:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/21/2025 3:25:00 PM. 50 Economy ticket for $126 per person are available. Travel duration is 17h 25m
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Volotea1h 40m02:10 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station3:50 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Volotea goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/20/2025 2:10:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/20/2025 3:50:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 1h 40m
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Vueling Airlines12h 15m08:15 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station8:30 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Vueling Airlines goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/20/2025 8:15:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/20/2025 8:30:00 PM. 50 Economy ticket for $229 per person are available. Travel duration is 12h 15m
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Lufthansa7h 25m010:50 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station6:15 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Lufthansa goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/20/2025 10:50:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/20/2025 6:15:00 PM. 50 Economy ticket for $311 per person are available. Travel duration is 7h 25m
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Hop!4h 30m05:50 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station10:20 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Hop! goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/20/2025 5:50:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/20/2025 10:20:00 PM. 50 Economy ticket for $396 per person are available. Travel duration is 4h 30m
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KLM - Royal Dutch Airlines5h 25m02:10 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station7:35 PMPrague AirportPrague Airport - T1/20EconomyA Flight from KLM - Royal Dutch Airlines goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/20/2025 2:10:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/20/2025 7:35:00 PM. 50 Economy ticket for $481 per person are available. Travel duration is 5h 25m
Cheapest Buses Saturday
Cheapest Flights Saturday
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FlixBus20h 30m09:30 AMLyonPerrache Bus Stop6:00 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/21/2025 9:30:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/22/2025 6:00:00 AM. 50 Economy ticket for $106 per person are available. Travel duration is 20h 30m
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FlixBus20h 45m09:30 AMLyonPerrache Bus Stop6:15 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/21/2025 9:30:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/22/2025 6:15:00 AM. 50 Economy ticket for $106 per person are available. Travel duration is 20h 45m
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FlixBus19h 0m03:15 AMLyonPerrache Bus Stop10:15 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/21/2025 3:15:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/21/2025 10:15:00 PM. 50 Economy ticket for $112 per person are available. Travel duration is 19h 0m
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FlixBus17h 25m010:00 PMLyonPerrache Bus Stop3:25 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/21/2025 10:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/22/2025 3:25:00 PM. 50 Economy ticket for $119 per person are available. Travel duration is 17h 25m
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FlixBus18h 10m010:00 PMLyonPerrache Bus Stop4:10 PMPragueČerný Most0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/21/2025 10:00:00 PM to Černý Most, Prague (Czech Republic) arriving at 12/22/2025 4:10:00 PM. 50 Economy ticket for $119 per person are available. Travel duration is 18h 10m
Cheapest Buses Sunday
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Volotea1h 40m09:55 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station11:35 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Volotea goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/22/2025 9:55:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/22/2025 11:35:00 AM. 50 Economy ticket for $84 per person are available. Travel duration is 1h 40m
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EasyJet Airline1h 40m011:40 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station1:20 PMPrague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/22/2025 11:40:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/22/2025 1:20:00 PM. 50 Economy ticket for $96 per person are available. Travel duration is 1h 40m
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LOT Polish Airlines / Polskie Linie Lotnicze6h 5m011:10 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station5:15 PMPrague AirportPrague Airport - T1/20EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/22/2025 11:10:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/22/2025 5:15:00 PM. 50 Economy ticket for $191 per person are available. Travel duration is 6h 5m
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Lufthansa CityLine4h 0m06:25 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station10:25 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Lufthansa CityLine goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/22/2025 6:25:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/22/2025 10:25:00 PM. 50 Economy ticket for $203 per person are available. Travel duration is 4h 0m
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Brussels Airlines3h 50m07:00 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station10:50 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Brussels Airlines goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/22/2025 7:00:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/22/2025 10:50:00 AM. 50 Economy ticket for $211 per person are available. Travel duration is 3h 50m
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FlixBus20h 30m09:30 AMLyonPerrache Bus Stop6:00 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/22/2025 9:30:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/23/2025 6:00:00 AM. 50 Economy ticket for $109 per person are available. Travel duration is 20h 30m
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FlixBus20h 45m09:30 AMLyonPerrache Bus Stop6:15 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/22/2025 9:30:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/23/2025 6:15:00 AM. 50 Economy ticket for $109 per person are available. Travel duration is 20h 45m
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FlixBus19h 0m03:15 AMLyonPerrache Bus Stop10:15 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/22/2025 3:15:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/22/2025 10:15:00 PM. 50 Economy ticket for $111 per person are available. Travel duration is 19h 0m
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FlixBus17h 25m010:00 PMLyonPerrache Bus Stop3:25 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/22/2025 10:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/23/2025 3:25:00 PM. 50 Economy ticket for $112 per person are available. Travel duration is 17h 25m
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FlixBus18h 10m010:00 PMLyonPerrache Bus Stop4:10 PMPragueČerný Most0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/22/2025 10:00:00 PM to Černý Most, Prague (Czech Republic) arriving at 12/23/2025 4:10:00 PM. 50 Economy ticket for $112 per person are available. Travel duration is 18h 10m
Cheapest Flights Monday
Cheapest Buses Monday
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FlixBus18h 45m03:30 AMLyonPerrache Bus Stop10:15 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/23/2025 3:30:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/23/2025 10:15:00 PM. 50 Economy ticket for $93 per person are available. Travel duration is 18h 45m
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FlixBus20h 30m09:30 AMLyonPerrache Bus Stop6:00 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/23/2025 9:30:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/24/2025 6:00:00 AM. 50 Economy ticket for $94 per person are available. Travel duration is 20h 30m
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FlixBus20h 45m09:30 AMLyonPerrache Bus Stop6:15 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/23/2025 9:30:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/24/2025 6:15:00 AM. 50 Economy ticket for $94 per person are available. Travel duration is 20h 45m
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FlixBus17h 35m05:20 AMLyonPerrache Bus Stop10:55 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/23/2025 5:20:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 12/23/2025 10:55:00 PM. 50 Economy ticket for $102 per person are available. Travel duration is 17h 35m
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FlixBus16h 55m09:00 PMLyonPerrache Bus Stop1:55 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/23/2025 9:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/24/2025 1:55:00 PM. 50 Economy ticket for $105 per person are available. Travel duration is 16h 55m
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Volotea1h 40m06:30 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station8:10 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Volotea goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/23/2025 6:30:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/23/2025 8:10:00 AM. 50 Economy ticket for $96 per person are available. Travel duration is 1h 40m
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EasyJet Airline18h 35m01:50 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station8:25 AMPrague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/23/2025 1:50:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/24/2025 8:25:00 AM. 50 Economy ticket for $125 per person are available. Travel duration is 18h 35m
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Wizz Air17h 50m010:45 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station4:35 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Wizz Air goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/23/2025 10:45:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/24/2025 4:35:00 PM. 50 Economy ticket for $165 per person are available. Travel duration is 17h 50m
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Hop!12h 5m08:20 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station8:25 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Hop! goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/23/2025 8:20:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/24/2025 8:25:00 AM. 50 Economy ticket for $184 per person are available. Travel duration is 12h 5m
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LOT Polish Airlines / Polskie Linie Lotnicze6h 5m011:10 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station5:15 PMPrague AirportPrague Airport - T1/20EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/23/2025 11:10:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/23/2025 5:15:00 PM. 50 Economy ticket for $191 per person are available. Travel duration is 6h 5m
Cheapest Buses Tuesday
Cheapest Flights Tuesday
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FlixBus14h 40m06:15 PMLyonPerrache Bus Stop8:55 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/24/2025 6:15:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 12/25/2025 8:55:00 AM. 50 Economy ticket for $96 per person are available. Travel duration is 14h 40m
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FlixBus17h 45m05:05 PMLyonPerrache Bus Stop10:50 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/24/2025 5:05:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/25/2025 10:50:00 AM. 50 Economy ticket for $96 per person are available. Travel duration is 17h 45m
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FlixBus15h 5m06:15 PMLyonPerrache Bus Stop9:20 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/24/2025 6:15:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/25/2025 9:20:00 AM. 50 Economy ticket for $96 per person are available. Travel duration is 15h 5m
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FlixBus16h 55m09:00 PMLyonPerrache Bus Stop1:55 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/24/2025 9:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/25/2025 1:55:00 PM. 50 Economy ticket for $102 per person are available. Travel duration is 16h 55m
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FlixBus17h 5m09:00 PMLyonPerrache Bus Stop2:05 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/24/2025 9:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/25/2025 2:05:00 PM. 50 Economy ticket for $102 per person are available. Travel duration is 17h 5m
Cheapest Buses Wednesday
What are the fastest trips from Lyon to Prague?
You can get to Prague from Lyon in just 1h 40m with a Flight from Volotea. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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Volotea1h 40m011:50 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station1:30 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Volotea goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/18/2025 11:50:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/18/2025 1:30:00 PM. 50 Economy ticket for $73 per person are available. Travel duration is 1h 40m
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Skyscanner1h 40m01:45 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station3:25 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Skyscanner goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/18/2025 1:45:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/18/2025 3:25:00 PM. 50 Economy ticket for $156 per person are available. Travel duration is 1h 40m
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Austrian Airlines3h 10m012:50 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station4:00 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Austrian Airlines goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/18/2025 12:50:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/18/2025 4:00:00 PM. 50 Economy ticket for $211 per person are available. Travel duration is 3h 10m
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Brussels Airlines6h 5m011:50 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station5:55 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Brussels Airlines goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/18/2025 11:50:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/18/2025 5:55:00 PM. 50 Economy ticket for $210 per person are available. Travel duration is 6h 5m
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EasyJet Airline10h 45m09:20 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station8:05 AMPrague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/18/2025 9:20:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/19/2025 8:05:00 AM. 50 Economy ticket for $125 per person are available. Travel duration is 10h 45m
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FlixBus14h 40m06:15 PMLyonPerrache Bus Stop8:55 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/18/2025 6:15:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 12/19/2025 8:55:00 AM. 50 Economy ticket for $112 per person are available. Travel duration is 14h 40m
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FlixBus15h 5m06:15 PMLyonPerrache Bus Stop9:20 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/18/2025 6:15:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/19/2025 9:20:00 AM. 50 Economy ticket for $112 per person are available. Travel duration is 15h 5m
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FlixBus16h 55m09:00 PMLyonPerrache Bus Stop1:55 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/18/2025 9:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/19/2025 1:55:00 PM. 50 Economy ticket for $122 per person are available. Travel duration is 16h 55m
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FlixBus17h 5m09:00 PMLyonPerrache Bus Stop2:05 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/18/2025 9:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/19/2025 2:05:00 PM. 50 Economy ticket for $122 per person are available. Travel duration is 17h 5m
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FlixBus18h 10m010:00 PMLyonPerrache Bus Stop4:10 PMPragueČerný Most0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/18/2025 10:00:00 PM to Černý Most, Prague (Czech Republic) arriving at 12/19/2025 4:10:00 PM. 50 Economy ticket for $126 per person are available. Travel duration is 18h 10m
Fastest Flights Thursday
Fastest Buses Thursday
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FlixBus16h 30m05:20 AMLyonPerrache Bus Stop9:50 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/19/2025 5:20:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/19/2025 9:50:00 PM. 50 Economy ticket for $115 per person are available. Travel duration is 16h 30m
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BlaBlaCar Bus16h 55m03:05 AMLyonPerrache Train Station8:00 PMPragueÚAN Florenc0EconomyA Bus from BlaBlaCar Bus goes from Perrache Train Station, Lyon (France) at 12/19/2025 3:05:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/19/2025 8:00:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 16h 55m
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BlaBlaCar Bus16h 55m03:05 AMLyonPerrache Bus Stop8:00 PMPragueÚAN Florenc0EconomyA Bus from BlaBlaCar Bus goes from Perrache Bus Stop, Lyon (France) at 12/19/2025 3:05:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/19/2025 8:00:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 16h 55m
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FlixBus17h 35m05:20 AMLyonPerrache Bus Stop10:55 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/19/2025 5:20:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 12/19/2025 10:55:00 PM. 50 Economy ticket for $115 per person are available. Travel duration is 17h 35m
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STARSHIPPER SAS21h 15m04:40 PMLyons St. Exupery AirportLyons St. Exupery Airport1:55 PMPragueWilsonova Bus Station0EconomyA Bus from STARSHIPPER SAS goes from Lyons St. Exupery Airport, Lyons St. Exupery Airport (France) at 12/19/2025 4:40:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/20/2025 1:55:00 PM. 50 Economy ticket for $186 per person are available. Travel duration is 21h 15m
Fastest Buses Friday
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Volotea1h 40m02:10 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station3:50 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Volotea goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/20/2025 2:10:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/20/2025 3:50:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 1h 40m
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Hop!4h 30m05:50 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station10:20 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Hop! goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/20/2025 5:50:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/20/2025 10:20:00 PM. 50 Economy ticket for $396 per person are available. Travel duration is 4h 30m
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KLM - Royal Dutch Airlines5h 25m02:10 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station7:35 PMPrague AirportPrague Airport - T1/20EconomyA Flight from KLM - Royal Dutch Airlines goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/20/2025 2:10:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/20/2025 7:35:00 PM. 50 Economy ticket for $481 per person are available. Travel duration is 5h 25m
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Lufthansa7h 25m010:50 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station6:15 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Lufthansa goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/20/2025 10:50:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/20/2025 6:15:00 PM. 50 Economy ticket for $311 per person are available. Travel duration is 7h 25m
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Vueling Airlines12h 15m08:15 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station8:30 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Vueling Airlines goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/20/2025 8:15:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/20/2025 8:30:00 PM. 50 Economy ticket for $229 per person are available. Travel duration is 12h 15m
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FlixBus14h 40m06:15 PMLyonPerrache Bus Stop8:55 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/20/2025 6:15:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 12/21/2025 8:55:00 AM. 50 Economy ticket for $122 per person are available. Travel duration is 14h 40m
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FlixBus15h 5m06:15 PMLyonPerrache Bus Stop9:20 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/20/2025 6:15:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/21/2025 9:20:00 AM. 50 Economy ticket for $122 per person are available. Travel duration is 15h 5m
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RegioJet15h 50m02:35 PMLyonPerrache Bus Stop6:25 AMPragueTrain station Wilsonova0EconomyA Bus from RegioJet goes from Perrache Bus Stop, Lyon (France) at 12/20/2025 2:35:00 PM to Train station Wilsonova, Prague (Czech Republic) arriving at 12/21/2025 6:25:00 AM. 50 Economy ticket for $106 per person are available. Travel duration is 15h 50m
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RegioJet15h 55m02:35 PMLyonPerrache Bus Stop6:30 AMPragueÚAN Florenc0EconomyA Bus from RegioJet goes from Perrache Bus Stop, Lyon (France) at 12/20/2025 2:35:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/21/2025 6:30:00 AM. 50 Economy ticket for $106 per person are available. Travel duration is 15h 55m
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FlixBus17h 25m010:00 PMLyonPerrache Bus Stop3:25 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/20/2025 10:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/21/2025 3:25:00 PM. 50 Economy ticket for $126 per person are available. Travel duration is 17h 25m
Fastest Flights Saturday
Fastest Buses Saturday
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FlixBus17h 25m010:00 PMLyonPerrache Bus Stop3:25 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/21/2025 10:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/22/2025 3:25:00 PM. 50 Economy ticket for $119 per person are available. Travel duration is 17h 25m
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FlixBus18h 10m010:00 PMLyonPerrache Bus Stop4:10 PMPragueČerný Most0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/21/2025 10:00:00 PM to Černý Most, Prague (Czech Republic) arriving at 12/22/2025 4:10:00 PM. 50 Economy ticket for $119 per person are available. Travel duration is 18h 10m
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FlixBus19h 0m03:15 AMLyonPerrache Bus Stop10:15 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/21/2025 3:15:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/21/2025 10:15:00 PM. 50 Economy ticket for $112 per person are available. Travel duration is 19h 0m
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FlixBus20h 30m09:30 AMLyonPerrache Bus Stop6:00 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/21/2025 9:30:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/22/2025 6:00:00 AM. 50 Economy ticket for $106 per person are available. Travel duration is 20h 30m
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FlixBus20h 45m09:30 AMLyonPerrache Bus Stop6:15 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/21/2025 9:30:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/22/2025 6:15:00 AM. 50 Economy ticket for $106 per person are available. Travel duration is 20h 45m
Fastest Buses Sunday
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Volotea1h 40m09:55 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station11:35 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Volotea goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/22/2025 9:55:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/22/2025 11:35:00 AM. 50 Economy ticket for $84 per person are available. Travel duration is 1h 40m
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EasyJet Airline1h 40m011:40 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station1:20 PMPrague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/22/2025 11:40:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/22/2025 1:20:00 PM. 50 Economy ticket for $96 per person are available. Travel duration is 1h 40m
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Brussels Airlines3h 50m07:00 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station10:50 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Brussels Airlines goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/22/2025 7:00:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/22/2025 10:50:00 AM. 50 Economy ticket for $211 per person are available. Travel duration is 3h 50m
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Lufthansa CityLine4h 0m06:25 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station10:25 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Lufthansa CityLine goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/22/2025 6:25:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/22/2025 10:25:00 PM. 50 Economy ticket for $203 per person are available. Travel duration is 4h 0m
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LOT Polish Airlines / Polskie Linie Lotnicze6h 5m011:10 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station5:15 PMPrague AirportPrague Airport - T1/20EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/22/2025 11:10:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/22/2025 5:15:00 PM. 50 Economy ticket for $191 per person are available. Travel duration is 6h 5m
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FlixBus17h 25m010:00 PMLyonPerrache Bus Stop3:25 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/22/2025 10:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/23/2025 3:25:00 PM. 50 Economy ticket for $112 per person are available. Travel duration is 17h 25m
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FlixBus18h 10m010:00 PMLyonPerrache Bus Stop4:10 PMPragueČerný Most0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/22/2025 10:00:00 PM to Černý Most, Prague (Czech Republic) arriving at 12/23/2025 4:10:00 PM. 50 Economy ticket for $112 per person are available. Travel duration is 18h 10m
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FlixBus19h 0m03:15 AMLyonPerrache Bus Stop10:15 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/22/2025 3:15:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/22/2025 10:15:00 PM. 50 Economy ticket for $111 per person are available. Travel duration is 19h 0m
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FlixBus20h 30m09:30 AMLyonPerrache Bus Stop6:00 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/22/2025 9:30:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/23/2025 6:00:00 AM. 50 Economy ticket for $109 per person are available. Travel duration is 20h 30m
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FlixBus20h 45m09:30 AMLyonPerrache Bus Stop6:15 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/22/2025 9:30:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/23/2025 6:15:00 AM. 50 Economy ticket for $109 per person are available. Travel duration is 20h 45m
Fastest Flights Monday
Fastest Buses Monday
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Volotea1h 40m06:30 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station8:10 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Volotea goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/23/2025 6:30:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/23/2025 8:10:00 AM. 50 Economy ticket for $96 per person are available. Travel duration is 1h 40m
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LOT Polish Airlines / Polskie Linie Lotnicze6h 5m011:10 AMLyons St. Exupery AirportAéroport St Exupéry Bus Station5:15 PMPrague AirportPrague Airport - T1/20EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/23/2025 11:10:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/23/2025 5:15:00 PM. 50 Economy ticket for $191 per person are available. Travel duration is 6h 5m
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Hop!12h 5m08:20 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station8:25 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Hop! goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/23/2025 8:20:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/24/2025 8:25:00 AM. 50 Economy ticket for $184 per person are available. Travel duration is 12h 5m
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Wizz Air17h 50m010:45 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station4:35 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Wizz Air goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/23/2025 10:45:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/24/2025 4:35:00 PM. 50 Economy ticket for $165 per person are available. Travel duration is 17h 50m
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EasyJet Airline18h 35m01:50 PMLyons St. Exupery AirportAéroport St Exupéry Bus Station8:25 AMPrague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Aéroport St Exupéry Bus Station, Lyons St. Exupery Airport (France) at 12/23/2025 1:50:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/24/2025 8:25:00 AM. 50 Economy ticket for $125 per person are available. Travel duration is 18h 35m
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FlixBus16h 55m09:00 PMLyonPerrache Bus Stop1:55 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/23/2025 9:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/24/2025 1:55:00 PM. 50 Economy ticket for $105 per person are available. Travel duration is 16h 55m
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FlixBus17h 35m05:20 AMLyonPerrache Bus Stop10:55 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/23/2025 5:20:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 12/23/2025 10:55:00 PM. 50 Economy ticket for $102 per person are available. Travel duration is 17h 35m
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FlixBus18h 45m03:30 AMLyonPerrache Bus Stop10:15 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/23/2025 3:30:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/23/2025 10:15:00 PM. 50 Economy ticket for $93 per person are available. Travel duration is 18h 45m
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FlixBus20h 30m09:30 AMLyonPerrache Bus Stop6:00 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/23/2025 9:30:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/24/2025 6:00:00 AM. 50 Economy ticket for $94 per person are available. Travel duration is 20h 30m
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FlixBus20h 45m09:30 AMLyonPerrache Bus Stop6:15 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/23/2025 9:30:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/24/2025 6:15:00 AM. 50 Economy ticket for $94 per person are available. Travel duration is 20h 45m
Fastest Flights Tuesday
Fastest Buses Tuesday
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FlixBus14h 40m06:15 PMLyonPerrache Bus Stop8:55 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/24/2025 6:15:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 12/25/2025 8:55:00 AM. 50 Economy ticket for $96 per person are available. Travel duration is 14h 40m
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FlixBus15h 5m06:15 PMLyonPerrache Bus Stop9:20 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/24/2025 6:15:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/25/2025 9:20:00 AM. 50 Economy ticket for $96 per person are available. Travel duration is 15h 5m
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FlixBus16h 55m09:00 PMLyonPerrache Bus Stop1:55 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/24/2025 9:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/25/2025 1:55:00 PM. 50 Economy ticket for $102 per person are available. Travel duration is 16h 55m
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FlixBus17h 5m09:00 PMLyonPerrache Bus Stop2:05 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/24/2025 9:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/25/2025 2:05:00 PM. 50 Economy ticket for $102 per person are available. Travel duration is 17h 5m
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FlixBus17h 45m05:05 PMLyonPerrache Bus Stop10:50 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Perrache Bus Stop, Lyon (France) at 12/24/2025 5:05:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/25/2025 10:50:00 AM. 50 Economy ticket for $96 per person are available. Travel duration is 17h 45m
Fastest Buses Wednesday
Here you will find all operators and timetables for a
Bus from Lyon to Prague
What are the most popular stations in Lyon and Prague?
In Lyon, you will usually depart from Perrache Bus Stop, Part-Dieu Train Station or Perrache Train Station, while in Prague you will be arriving at Wilsonova Bus Station, ÚAN Florenc or Černý Most, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Prague from Lyon? With 7 connections between 3 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Lyon and Prague, you can pay as low as $62 with a Bus from BlaBlaCar Bus.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from Volotea: you will get to Prague in just 1h 40m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Lyon and Prague are FlixBus, Volotea and EasyJet Airline, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Lyon and Prague is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Caluire-et-Cuire or to Horoměřice, and look at flights from Lyons St. Exupery Airport, and landing at Prague Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Lyon to Prague?
The most popular companies between Lyon and Prague, are FlixBus, Volotea and EasyJet Airline. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus, BlaBlaCar Bus, RegioJet and 1 more.
Airlines: Volotea, EasyJet Airline, Brussels Airlines and 9 more.
All you need to know when you travel from Lyon to Prague
Check all information on comfort and services on all modes of transports from Lyon to Prague. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Lyon to Prague
How can I reach Prague from Lyon?
Every day, there are on average 7 connections between Bus and Flight, with which you can get to Prague from Lyon.
How far is Prague from Lyon?
The distance between Lyon and Prague is 535.0 miles.
What is the most ecofriendly mode of transport between Lyon and Prague?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 23 kgs of CO2, a train 30 kgs, a car 146 kgs, and a flight 212 kgs.
What is the cheapest mode of transport from Lyon to Prague?
You can get to Prague with just $62 by taking a Bus from BlaBlaCar Bus.
What is the fastest way to get from Lyon to Prague?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Prague in just 1h 40m with a Flight from Volotea.
More routes to Lyon and to Prague
Looking for more options? Here you can see the most popular routes to Lyon and to Prague. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Lyon
- Alicante to Lyon
- Annecy to Lyon
- Barcelona to Lyon
- Bayonne to Lyon
- Bologna to Lyon
- Bordeaux to Lyon
- Braga to Lyon
- Caen to Lyon
- Dijon to Lyon
- Dusseldorf to Lyon
- Geneva to Lyon
- Genoa to Lyon
- Lille to Lyon
- Lisbon to Lyon
- London to Lyon
- Lyons St. Exupery Airport to Lyon
- Marseille to Lyon
- Milan to Lyon
- Nancy to Lyon
- Paris to Lyon
- Rome to Lyon
- Toulouse to Lyon
- Turin to Lyon
- Valencia to Lyon
- Trips to Prague
- Belgrade to Prague
- Berlin to Prague
- Bologna to Prague
- Bremen to Prague
- Budapest to Prague
- Dresden to Prague
- Florence to Prague
- Hamburg to Prague
- Humpolec to Prague
- Jihlava to Prague
- Kosice to Prague
- Krakow to Prague
- Leipzig to Prague
- Linz to Prague
- Minsk to Prague
- Mladá Boleslav to Prague
- Munich to Prague
- Ostrava to Prague
- Pelhřimov to Prague
- Pilsen to Prague
- Riga to Prague
- Rome to Prague
- Vienna to Prague
- Zilina to Prague

