What is the best way to travel from Rome to Prague?
Looking for a trip? Compare all the available Flights and Buses for the journey to Prague from Rome. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 1 available companies to find your perfect trip!
What is the cheapest way to reach Prague from Rome?
You can get to Prague with just $35 by taking a Flight from LC Perú, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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FlixBus22h 45m05:25 PMRomeAnagnina Bus Station4:10 PMPragueČerný Most0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 2/7/2026 5:25:00 PM to Černý Most, Prague (Czech Republic) arriving at 2/8/2026 4:10:00 PM. 50 Economy ticket for $86 per person are available. Travel duration is 22h 45m
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FlixBus24h 10m05:25 PMRomeAnagnina Bus Station5:35 PMPragueHradčanská0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 2/7/2026 5:25:00 PM to Hradčanská, Prague (Czech Republic) arriving at 2/8/2026 5:35:00 PM. 50 Economy ticket for $86 per person are available. Travel duration is 24h 10m
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FlixBus27h 0m05:00 PMRomeTiburtina Bus Station8:00 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/7/2026 5:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 2/8/2026 8:00:00 PM. 50 Economy ticket for $87 per person are available. Travel duration is 27h 0m
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FlixBus25h 45m05:25 PMRomeAnagnina Bus Station7:10 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 2/7/2026 5:25:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 2/8/2026 7:10:00 PM. 50 Economy ticket for $87 per person are available. Travel duration is 25h 45m
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FlixBus19h 55m05:25 PMRomeAnagnina Bus Station1:20 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 2/7/2026 5:25:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 2/8/2026 1:20:00 PM. 50 Economy ticket for $87 per person are available. Travel duration is 19h 55m
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ITA Airways17h 0m03:00 PMRome Fiumicino AirportRome Fiumicino Airport8:00 AMPrague AirportPrague Airport0EconomyA Flight from ITA Airways goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/7/2026 3:00:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 2/8/2026 8:00:00 AM. 50 Economy ticket for $114 per person are available. Travel duration is 17h 0m
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Vueling Airlines15h 30m06:40 PMRome Fiumicino AirportRome Fiumicino Airport10:10 AMPrague AirportPrague Airport0EconomyA Flight from Vueling Airlines goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/7/2026 6:40:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 2/8/2026 10:10:00 AM. 50 Economy ticket for $119 per person are available. Travel duration is 15h 30m
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EasyJet Airline16h 40m07:45 PMRome Fiumicino AirportRome Fiumicino Airport12:25 PMPrague AirportPrague Airport0EconomyA Flight from EasyJet Airline goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/7/2026 7:45:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 2/8/2026 12:25:00 PM. 50 Economy ticket for $157 per person are available. Travel duration is 16h 40m
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Iberia15h 30m06:40 PMRome Fiumicino AirportRome Fiumicino Airport10:10 AMPrague AirportPrague Airport0EconomyA Flight from Iberia goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/7/2026 6:40:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 2/8/2026 10:10:00 AM. 50 Economy ticket for $185 per person are available. Travel duration is 15h 30m
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Lufthansa4h 40m08:25 AMRome Fiumicino AirportRome Fiumicino Airport1:05 PMPrague AirportPrague Airport0EconomyA Flight from Lufthansa goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/7/2026 8:25:00 AM to Prague Airport, Prague Airport (Czech Republic) arriving at 2/7/2026 1:05:00 PM. 50 Economy ticket for $288 per person are available. Travel duration is 4h 40m
Cheapest Buses Saturday
Cheapest Flights Saturday
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LC Perú2h 0m06:40 AMRome Fiumicino AirportRome Fiumicino Airport8:40 AMPrague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/8/2026 6:40:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 2/8/2026 8:40:00 AM. 50 Economy ticket for $35 per person are available. Travel duration is 2h 0m
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Skyscanner1h 50m04:25 PMRome Ciampino AirportRome Ciampino Airport6:15 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Skyscanner goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 2/8/2026 4:25:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 2/8/2026 6:15:00 PM. 50 Economy ticket for $58 per person are available. Travel duration is 1h 50m
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Buzz1h 50m08:35 AMRome Ciampino AirportRome Ciampino Airport10:25 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Buzz goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 2/8/2026 8:35:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 2/8/2026 10:25:00 AM. 50 Economy ticket for $59 per person are available. Travel duration is 1h 50m
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Smartwings2h 0m02:00 PMRome Fiumicino AirportRome Fiumicino Airport4:00 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Smartwings goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/8/2026 2:00:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 2/8/2026 4:00:00 PM. 50 Economy ticket for $70 per person are available. Travel duration is 2h 0m
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Wizz Air19h 5m09:30 PMRome Fiumicino AirportRome Fiumicino Airport4:35 PMPrague AirportPrague Airport0EconomyA Flight from Wizz Air goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/8/2026 9:30:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 2/9/2026 4:35:00 PM. 50 Economy ticket for $114 per person are available. Travel duration is 19h 5m
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FlixBus27h 40m011:35 PMRomeAnagnina Bus Station3:15 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 2/8/2026 11:35:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 2/10/2026 3:15:00 AM. 50 Economy ticket for $87 per person are available. Travel duration is 27h 40m
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FlixBus24h 30m09:00 PMRomeTiburtina Bus Station9:30 PMPragueČerný Most0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/8/2026 9:00:00 PM to Černý Most, Prague (Czech Republic) arriving at 2/9/2026 9:30:00 PM. 50 Economy ticket for $94 per person are available. Travel duration is 24h 30m
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FlixBus23h 20m09:00 PMRomeTiburtina Bus Station8:20 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/8/2026 9:00:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 2/9/2026 8:20:00 PM. 50 Economy ticket for $94 per person are available. Travel duration is 23h 20m
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FlixBus20h 30m09:00 PMRomeTiburtina Bus Station5:30 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/8/2026 9:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 2/9/2026 5:30:00 PM. 50 Economy ticket for $95 per person are available. Travel duration is 20h 30m
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FlixBus20h 45m09:00 PMRomeTiburtina Bus Station5:45 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/8/2026 9:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 2/9/2026 5:45:00 PM. 50 Economy ticket for $95 per person are available. Travel duration is 20h 45m
Cheapest Flights Sunday
Cheapest Buses Sunday
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FlixBus20h 45m09:30 AMRomeTiburtina Bus Station6:15 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/9/2026 9:30:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 2/10/2026 6:15:00 AM. 50 Economy ticket for $83 per person are available. Travel duration is 20h 45m
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FlixBus20h 45m09:00 PMRomeTiburtina Bus Station5:45 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/9/2026 9:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 2/10/2026 5:45:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 20h 45m
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FlixBus24h 40m09:20 PMRomeTiburtina Bus Station10:00 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/9/2026 9:20:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 2/10/2026 10:00:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 24h 40m
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FlixBus20h 30m09:30 AMRomeTiburtina Bus Station6:00 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/9/2026 9:30:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 2/10/2026 6:00:00 AM. 50 Economy ticket for $83 per person are available. Travel duration is 20h 30m
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FlixBus27h 0m05:00 PMRomeTiburtina Bus Station8:00 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/9/2026 5:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 2/10/2026 8:00:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 27h 0m
Cheapest Buses Monday
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Skyscanner1h 50m06:15 AMRome Ciampino AirportRome Ciampino Airport8:05 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Skyscanner goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 2/10/2026 6:15:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 2/10/2026 8:05:00 AM. 50 Economy ticket for $39 per person are available. Travel duration is 1h 50m
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LC Perú2h 0m06:40 AMRome Fiumicino AirportRome Fiumicino Airport8:40 AMPrague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/10/2026 6:40:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 2/10/2026 8:40:00 AM. 50 Economy ticket for $47 per person are available. Travel duration is 2h 0m
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Ryanair11h 25m09:30 AMRome Ciampino AirportRome Ciampino Airport8:55 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Ryanair goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 2/10/2026 9:30:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 2/10/2026 8:55:00 PM. 50 Economy ticket for $67 per person are available. Travel duration is 11h 25m
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Air Malta10h 55m08:55 AMRome Fiumicino AirportRome Fiumicino Airport7:50 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Air Malta goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/10/2026 8:55:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 2/10/2026 7:50:00 PM. 50 Economy ticket for $114 per person are available. Travel duration is 10h 55m
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Siam Air Transport11h 20m09:10 PMRome Fiumicino AirportRome Fiumicino Airport8:30 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Siam Air Transport goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/10/2026 9:10:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 2/11/2026 8:30:00 AM. 50 Economy ticket for $116 per person are available. Travel duration is 11h 20m
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FlixBus27h 0m05:00 PMRomeTiburtina Bus Station8:00 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/10/2026 5:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 2/11/2026 8:00:00 PM. 50 Economy ticket for $80 per person are available. Travel duration is 27h 0m
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FlixBus20h 30m09:00 PMRomeTiburtina Bus Station5:30 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/10/2026 9:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 2/11/2026 5:30:00 PM. 50 Economy ticket for $81 per person are available. Travel duration is 20h 30m
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FlixBus26h 55m09:00 PMRomeTiburtina Bus Station11:55 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/10/2026 9:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 2/11/2026 11:55:00 PM. 50 Economy ticket for $81 per person are available. Travel duration is 26h 55m
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FlixBus20h 45m09:00 PMRomeTiburtina Bus Station5:45 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/10/2026 9:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 2/11/2026 5:45:00 PM. 50 Economy ticket for $81 per person are available. Travel duration is 20h 45m
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FlixBus24h 15m01:05 PMRomeAnagnina Bus Station1:20 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 2/10/2026 1:05:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 2/11/2026 1:20:00 PM. 50 Economy ticket for $81 per person are available. Travel duration is 24h 15m
Cheapest Flights Tuesday
Cheapest Buses Tuesday
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FlixBus20h 30m09:00 PMRomeTiburtina Bus Station5:30 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/11/2026 9:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 2/12/2026 5:30:00 PM. 50 Economy ticket for $74 per person are available. Travel duration is 20h 30m
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FlixBus20h 45m09:00 PMRomeTiburtina Bus Station5:45 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/11/2026 9:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 2/12/2026 5:45:00 PM. 50 Economy ticket for $74 per person are available. Travel duration is 20h 45m
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FlixBus24h 15m01:05 PMRomeAnagnina Bus Station1:20 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 2/11/2026 1:05:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 2/12/2026 1:20:00 PM. 50 Economy ticket for $74 per person are available. Travel duration is 24h 15m
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FlixBus24h 25m01:05 PMRomeAnagnina Bus Station1:30 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 2/11/2026 1:05:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 2/12/2026 1:30:00 PM. 50 Economy ticket for $74 per person are available. Travel duration is 24h 25m
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FlixBus26h 10m05:00 PMRomeTiburtina Bus Station7:10 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/11/2026 5:00:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 2/12/2026 7:10:00 PM. 50 Economy ticket for $74 per person are available. Travel duration is 26h 10m
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EasyJet Airline23h 15m05:30 PMRome Fiumicino AirportRome Fiumicino Airport4:45 PMPrague AirportPrague Airport0EconomyA Flight from EasyJet Airline goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/11/2026 5:30:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 2/12/2026 4:45:00 PM. 50 Economy ticket for $147 per person are available. Travel duration is 23h 15m
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ITA Airways14h 10m06:30 AMRome Fiumicino AirportRome Fiumicino Airport8:40 PMPrague AirportPrague Airport0EconomyA Flight from ITA Airways goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/11/2026 6:30:00 AM to Prague Airport, Prague Airport (Czech Republic) arriving at 2/11/2026 8:40:00 PM. 50 Economy ticket for $149 per person are available. Travel duration is 14h 10m
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Air Serbia12h 5m08:40 PMRome Fiumicino AirportRome Fiumicino Airport8:45 AMPrague AirportPrague Airport0EconomyA Flight from Air Serbia goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/11/2026 8:40:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 2/12/2026 8:45:00 AM. 50 Economy ticket for $150 per person are available. Travel duration is 12h 5m
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Wizz Air13h 5m06:10 PMRome Fiumicino AirportRome Fiumicino Airport7:15 AMPrague AirportPrague Airport0EconomyA Flight from Wizz Air goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/11/2026 6:10:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 2/12/2026 7:15:00 AM. 50 Economy ticket for $160 per person are available. Travel duration is 13h 5m
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Vueling Airlines16h 0m06:10 PMRome Fiumicino AirportRome Fiumicino Airport10:10 AMPrague AirportPrague Airport0EconomyA Flight from Vueling Airlines goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/11/2026 6:10:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 2/12/2026 10:10:00 AM. 50 Economy ticket for $169 per person are available. Travel duration is 16h 0m
Cheapest Buses Wednesday
Cheapest Flights Wednesday
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Skyscanner1h 50m06:15 AMRome Ciampino AirportRome Ciampino Airport8:05 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Skyscanner goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 2/12/2026 6:15:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 2/12/2026 8:05:00 AM. 50 Economy ticket for $66 per person are available. Travel duration is 1h 50m
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Smartwings2h 0m02:00 PMRome Fiumicino AirportRome Fiumicino Airport4:00 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Smartwings goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/12/2026 2:00:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 2/12/2026 4:00:00 PM. 50 Economy ticket for $72 per person are available. Travel duration is 2h 0m
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LC Perú2h 0m06:40 AMRome Fiumicino AirportRome Fiumicino Airport8:40 AMPrague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/12/2026 6:40:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 2/12/2026 8:40:00 AM. 50 Economy ticket for $116 per person are available. Travel duration is 2h 0m
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EasyJet Airline7h 45m08:05 AMRome Fiumicino AirportRome Fiumicino Airport3:50 PMPrague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/12/2026 8:05:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 2/12/2026 3:50:00 PM. 50 Economy ticket for $129 per person are available. Travel duration is 7h 45m
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Wizz Air9h 45m09:25 PMRome Fiumicino AirportRome Fiumicino Airport7:10 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Wizz Air goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/12/2026 9:25:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 2/13/2026 7:10:00 AM. 50 Economy ticket for $147 per person are available. Travel duration is 9h 45m
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FlixBus27h 55m010:55 PMRomeTiburtina Bus Station2:50 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/12/2026 10:55:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 2/14/2026 2:50:00 AM. 50 Economy ticket for $69 per person are available. Travel duration is 27h 55m
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FlixBus23h 25m011:10 AMRomeAnagnina Bus Station10:35 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 2/12/2026 11:10:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 2/13/2026 10:35:00 AM. 50 Economy ticket for $69 per person are available. Travel duration is 23h 25m
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FlixBus24h 0m010:55 PMRomeTiburtina Bus Station10:55 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/12/2026 10:55:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 2/13/2026 10:55:00 PM. 50 Economy ticket for $69 per person are available. Travel duration is 24h 0m
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FlixBus20h 45m09:30 AMRomeTiburtina Bus Station6:15 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/12/2026 9:30:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 2/13/2026 6:15:00 AM. 50 Economy ticket for $70 per person are available. Travel duration is 20h 45m
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FlixBus20h 30m09:30 AMRomeTiburtina Bus Station6:00 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/12/2026 9:30:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 2/13/2026 6:00:00 AM. 50 Economy ticket for $70 per person are available. Travel duration is 20h 30m
Cheapest Flights Thursday
Cheapest Buses Thursday
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FlixBus24h 50m05:00 PMRomeTiburtina Bus Station5:50 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/13/2026 5:00:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 2/14/2026 5:50:00 PM. 50 Economy ticket for $74 per person are available. Travel duration is 24h 50m
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FlixBus27h 5m01:05 PMRomeAnagnina Bus Station4:10 PMPragueČerný Most0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 2/13/2026 1:05:00 PM to Černý Most, Prague (Czech Republic) arriving at 2/14/2026 4:10:00 PM. 50 Economy ticket for $74 per person are available. Travel duration is 27h 5m
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FlixBus27h 0m05:00 PMRomeTiburtina Bus Station8:00 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/13/2026 5:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 2/14/2026 8:00:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 27h 0m
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FlixBus22h 45m011:50 AMRomeTiburtina Bus Station10:35 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/13/2026 11:50:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 2/14/2026 10:35:00 AM. 50 Economy ticket for $77 per person are available. Travel duration is 22h 45m
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FlixBus26h 55m05:25 PMRomeAnagnina Bus Station8:20 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 2/13/2026 5:25:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 2/14/2026 8:20:00 PM. 50 Economy ticket for $78 per person are available. Travel duration is 26h 55m
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Smartwings2h 0m02:00 PMRome Fiumicino AirportRome Fiumicino Airport4:00 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Smartwings goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/13/2026 2:00:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 2/13/2026 4:00:00 PM. 50 Economy ticket for $89 per person are available. Travel duration is 2h 0m
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Skyscanner5h 40m04:25 PMRome Ciampino AirportRome Ciampino Airport10:05 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Skyscanner goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 2/13/2026 4:25:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 2/13/2026 10:05:00 PM. 50 Economy ticket for $99 per person are available. Travel duration is 5h 40m
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Wizz Air13h 25m08:40 AMRome Fiumicino AirportRome Fiumicino Airport10:05 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Wizz Air goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/13/2026 8:40:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 2/13/2026 10:05:00 PM. 50 Economy ticket for $106 per person are available. Travel duration is 13h 25m
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Air Serbia12h 5m08:40 PMRome Fiumicino AirportRome Fiumicino Airport8:45 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Air Serbia goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/13/2026 8:40:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 2/14/2026 8:45:00 AM. 50 Economy ticket for $145 per person are available. Travel duration is 12h 5m
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Aegean Airlines23h 55m09:45 AMRome Fiumicino AirportRome Fiumicino Airport9:40 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Aegean Airlines goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/13/2026 9:45:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 2/14/2026 9:40:00 AM. 50 Economy ticket for $162 per person are available. Travel duration is 23h 55m
Cheapest Buses Friday
Cheapest Flights Friday
What are the fastest trips from Rome to Prague?
You can get to Prague from Rome in just 1h 50m with a Flight from Skyscanner. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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Lufthansa4h 40m08:25 AMRome Fiumicino AirportRome Fiumicino Airport1:05 PMPrague AirportPrague Airport0EconomyA Flight from Lufthansa goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/7/2026 8:25:00 AM to Prague Airport, Prague Airport (Czech Republic) arriving at 2/7/2026 1:05:00 PM. 50 Economy ticket for $288 per person are available. Travel duration is 4h 40m
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Vueling Airlines15h 30m06:40 PMRome Fiumicino AirportRome Fiumicino Airport10:10 AMPrague AirportPrague Airport0EconomyA Flight from Vueling Airlines goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/7/2026 6:40:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 2/8/2026 10:10:00 AM. 50 Economy ticket for $119 per person are available. Travel duration is 15h 30m
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Iberia15h 30m06:40 PMRome Fiumicino AirportRome Fiumicino Airport10:10 AMPrague AirportPrague Airport0EconomyA Flight from Iberia goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/7/2026 6:40:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 2/8/2026 10:10:00 AM. 50 Economy ticket for $185 per person are available. Travel duration is 15h 30m
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EasyJet Airline16h 40m07:45 PMRome Fiumicino AirportRome Fiumicino Airport12:25 PMPrague AirportPrague Airport0EconomyA Flight from EasyJet Airline goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/7/2026 7:45:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 2/8/2026 12:25:00 PM. 50 Economy ticket for $157 per person are available. Travel duration is 16h 40m
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ITA Airways17h 0m03:00 PMRome Fiumicino AirportRome Fiumicino Airport8:00 AMPrague AirportPrague Airport0EconomyA Flight from ITA Airways goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/7/2026 3:00:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 2/8/2026 8:00:00 AM. 50 Economy ticket for $114 per person are available. Travel duration is 17h 0m
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FlixBus19h 55m05:25 PMRomeAnagnina Bus Station1:20 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 2/7/2026 5:25:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 2/8/2026 1:20:00 PM. 50 Economy ticket for $87 per person are available. Travel duration is 19h 55m
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FlixBus22h 45m05:25 PMRomeAnagnina Bus Station4:10 PMPragueČerný Most0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 2/7/2026 5:25:00 PM to Černý Most, Prague (Czech Republic) arriving at 2/8/2026 4:10:00 PM. 50 Economy ticket for $86 per person are available. Travel duration is 22h 45m
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FlixBus24h 10m05:25 PMRomeAnagnina Bus Station5:35 PMPragueHradčanská0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 2/7/2026 5:25:00 PM to Hradčanská, Prague (Czech Republic) arriving at 2/8/2026 5:35:00 PM. 50 Economy ticket for $86 per person are available. Travel duration is 24h 10m
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FlixBus25h 45m05:25 PMRomeAnagnina Bus Station7:10 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 2/7/2026 5:25:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 2/8/2026 7:10:00 PM. 50 Economy ticket for $87 per person are available. Travel duration is 25h 45m
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FlixBus27h 0m05:00 PMRomeTiburtina Bus Station8:00 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/7/2026 5:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 2/8/2026 8:00:00 PM. 50 Economy ticket for $87 per person are available. Travel duration is 27h 0m
Fastest Flights Saturday
Fastest Buses Saturday
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Skyscanner1h 50m04:25 PMRome Ciampino AirportRome Ciampino Airport6:15 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Skyscanner goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 2/8/2026 4:25:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 2/8/2026 6:15:00 PM. 50 Economy ticket for $58 per person are available. Travel duration is 1h 50m
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Buzz1h 50m08:35 AMRome Ciampino AirportRome Ciampino Airport10:25 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Buzz goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 2/8/2026 8:35:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 2/8/2026 10:25:00 AM. 50 Economy ticket for $59 per person are available. Travel duration is 1h 50m
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LC Perú2h 0m06:40 AMRome Fiumicino AirportRome Fiumicino Airport8:40 AMPrague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/8/2026 6:40:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 2/8/2026 8:40:00 AM. 50 Economy ticket for $35 per person are available. Travel duration is 2h 0m
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Smartwings2h 0m02:00 PMRome Fiumicino AirportRome Fiumicino Airport4:00 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Smartwings goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/8/2026 2:00:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 2/8/2026 4:00:00 PM. 50 Economy ticket for $70 per person are available. Travel duration is 2h 0m
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Wizz Air19h 5m09:30 PMRome Fiumicino AirportRome Fiumicino Airport4:35 PMPrague AirportPrague Airport0EconomyA Flight from Wizz Air goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/8/2026 9:30:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 2/9/2026 4:35:00 PM. 50 Economy ticket for $114 per person are available. Travel duration is 19h 5m
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FlixBus20h 30m09:00 PMRomeTiburtina Bus Station5:30 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/8/2026 9:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 2/9/2026 5:30:00 PM. 50 Economy ticket for $95 per person are available. Travel duration is 20h 30m
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FlixBus20h 45m09:00 PMRomeTiburtina Bus Station5:45 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/8/2026 9:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 2/9/2026 5:45:00 PM. 50 Economy ticket for $95 per person are available. Travel duration is 20h 45m
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FlixBus23h 20m09:00 PMRomeTiburtina Bus Station8:20 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/8/2026 9:00:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 2/9/2026 8:20:00 PM. 50 Economy ticket for $94 per person are available. Travel duration is 23h 20m
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FlixBus24h 30m09:00 PMRomeTiburtina Bus Station9:30 PMPragueČerný Most0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/8/2026 9:00:00 PM to Černý Most, Prague (Czech Republic) arriving at 2/9/2026 9:30:00 PM. 50 Economy ticket for $94 per person are available. Travel duration is 24h 30m
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FlixBus27h 40m011:35 PMRomeAnagnina Bus Station3:15 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 2/8/2026 11:35:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 2/10/2026 3:15:00 AM. 50 Economy ticket for $87 per person are available. Travel duration is 27h 40m
Fastest Flights Sunday
Fastest Buses Sunday
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FlixBus20h 30m09:30 AMRomeTiburtina Bus Station6:00 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/9/2026 9:30:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 2/10/2026 6:00:00 AM. 50 Economy ticket for $83 per person are available. Travel duration is 20h 30m
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FlixBus20h 45m09:30 AMRomeTiburtina Bus Station6:15 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/9/2026 9:30:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 2/10/2026 6:15:00 AM. 50 Economy ticket for $83 per person are available. Travel duration is 20h 45m
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FlixBus20h 45m09:00 PMRomeTiburtina Bus Station5:45 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/9/2026 9:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 2/10/2026 5:45:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 20h 45m
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FlixBus24h 40m09:20 PMRomeTiburtina Bus Station10:00 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/9/2026 9:20:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 2/10/2026 10:00:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 24h 40m
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FlixBus27h 0m05:00 PMRomeTiburtina Bus Station8:00 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/9/2026 5:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 2/10/2026 8:00:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 27h 0m
Fastest Buses Monday
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Skyscanner1h 50m06:15 AMRome Ciampino AirportRome Ciampino Airport8:05 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Skyscanner goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 2/10/2026 6:15:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 2/10/2026 8:05:00 AM. 50 Economy ticket for $39 per person are available. Travel duration is 1h 50m
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LC Perú2h 0m06:40 AMRome Fiumicino AirportRome Fiumicino Airport8:40 AMPrague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/10/2026 6:40:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 2/10/2026 8:40:00 AM. 50 Economy ticket for $47 per person are available. Travel duration is 2h 0m
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Air Malta10h 55m08:55 AMRome Fiumicino AirportRome Fiumicino Airport7:50 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Air Malta goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/10/2026 8:55:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 2/10/2026 7:50:00 PM. 50 Economy ticket for $114 per person are available. Travel duration is 10h 55m
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Siam Air Transport11h 20m09:10 PMRome Fiumicino AirportRome Fiumicino Airport8:30 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Siam Air Transport goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/10/2026 9:10:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 2/11/2026 8:30:00 AM. 50 Economy ticket for $116 per person are available. Travel duration is 11h 20m
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Ryanair11h 25m09:30 AMRome Ciampino AirportRome Ciampino Airport8:55 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Ryanair goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 2/10/2026 9:30:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 2/10/2026 8:55:00 PM. 50 Economy ticket for $67 per person are available. Travel duration is 11h 25m
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FlixBus20h 30m09:00 PMRomeTiburtina Bus Station5:30 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/10/2026 9:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 2/11/2026 5:30:00 PM. 50 Economy ticket for $81 per person are available. Travel duration is 20h 30m
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FlixBus20h 45m09:00 PMRomeTiburtina Bus Station5:45 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/10/2026 9:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 2/11/2026 5:45:00 PM. 50 Economy ticket for $81 per person are available. Travel duration is 20h 45m
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FlixBus24h 15m01:05 PMRomeAnagnina Bus Station1:20 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 2/10/2026 1:05:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 2/11/2026 1:20:00 PM. 50 Economy ticket for $81 per person are available. Travel duration is 24h 15m
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FlixBus26h 55m09:00 PMRomeTiburtina Bus Station11:55 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/10/2026 9:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 2/11/2026 11:55:00 PM. 50 Economy ticket for $81 per person are available. Travel duration is 26h 55m
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FlixBus27h 0m05:00 PMRomeTiburtina Bus Station8:00 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/10/2026 5:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 2/11/2026 8:00:00 PM. 50 Economy ticket for $80 per person are available. Travel duration is 27h 0m
Fastest Flights Tuesday
Fastest Buses Tuesday
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Air Serbia12h 5m08:40 PMRome Fiumicino AirportRome Fiumicino Airport8:45 AMPrague AirportPrague Airport0EconomyA Flight from Air Serbia goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/11/2026 8:40:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 2/12/2026 8:45:00 AM. 50 Economy ticket for $150 per person are available. Travel duration is 12h 5m
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Wizz Air13h 5m06:10 PMRome Fiumicino AirportRome Fiumicino Airport7:15 AMPrague AirportPrague Airport0EconomyA Flight from Wizz Air goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/11/2026 6:10:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 2/12/2026 7:15:00 AM. 50 Economy ticket for $160 per person are available. Travel duration is 13h 5m
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ITA Airways14h 10m06:30 AMRome Fiumicino AirportRome Fiumicino Airport8:40 PMPrague AirportPrague Airport0EconomyA Flight from ITA Airways goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/11/2026 6:30:00 AM to Prague Airport, Prague Airport (Czech Republic) arriving at 2/11/2026 8:40:00 PM. 50 Economy ticket for $149 per person are available. Travel duration is 14h 10m
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Vueling Airlines16h 0m06:10 PMRome Fiumicino AirportRome Fiumicino Airport10:10 AMPrague AirportPrague Airport0EconomyA Flight from Vueling Airlines goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/11/2026 6:10:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 2/12/2026 10:10:00 AM. 50 Economy ticket for $169 per person are available. Travel duration is 16h 0m
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EasyJet Airline23h 15m05:30 PMRome Fiumicino AirportRome Fiumicino Airport4:45 PMPrague AirportPrague Airport0EconomyA Flight from EasyJet Airline goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/11/2026 5:30:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 2/12/2026 4:45:00 PM. 50 Economy ticket for $147 per person are available. Travel duration is 23h 15m
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FlixBus20h 30m09:00 PMRomeTiburtina Bus Station5:30 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/11/2026 9:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 2/12/2026 5:30:00 PM. 50 Economy ticket for $74 per person are available. Travel duration is 20h 30m
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FlixBus20h 45m09:00 PMRomeTiburtina Bus Station5:45 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/11/2026 9:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 2/12/2026 5:45:00 PM. 50 Economy ticket for $74 per person are available. Travel duration is 20h 45m
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FlixBus24h 15m01:05 PMRomeAnagnina Bus Station1:20 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 2/11/2026 1:05:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 2/12/2026 1:20:00 PM. 50 Economy ticket for $74 per person are available. Travel duration is 24h 15m
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FlixBus24h 25m01:05 PMRomeAnagnina Bus Station1:30 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 2/11/2026 1:05:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 2/12/2026 1:30:00 PM. 50 Economy ticket for $74 per person are available. Travel duration is 24h 25m
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FlixBus26h 10m05:00 PMRomeTiburtina Bus Station7:10 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/11/2026 5:00:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 2/12/2026 7:10:00 PM. 50 Economy ticket for $74 per person are available. Travel duration is 26h 10m
Fastest Flights Wednesday
Fastest Buses Wednesday
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Skyscanner1h 50m06:15 AMRome Ciampino AirportRome Ciampino Airport8:05 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Skyscanner goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 2/12/2026 6:15:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 2/12/2026 8:05:00 AM. 50 Economy ticket for $66 per person are available. Travel duration is 1h 50m
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Smartwings2h 0m02:00 PMRome Fiumicino AirportRome Fiumicino Airport4:00 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Smartwings goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/12/2026 2:00:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 2/12/2026 4:00:00 PM. 50 Economy ticket for $72 per person are available. Travel duration is 2h 0m
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LC Perú2h 0m06:40 AMRome Fiumicino AirportRome Fiumicino Airport8:40 AMPrague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/12/2026 6:40:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 2/12/2026 8:40:00 AM. 50 Economy ticket for $116 per person are available. Travel duration is 2h 0m
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EasyJet Airline7h 45m08:05 AMRome Fiumicino AirportRome Fiumicino Airport3:50 PMPrague AirportPrague Airport - T1/20EconomyA Flight from EasyJet Airline goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/12/2026 8:05:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 2/12/2026 3:50:00 PM. 50 Economy ticket for $129 per person are available. Travel duration is 7h 45m
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Wizz Air9h 45m09:25 PMRome Fiumicino AirportRome Fiumicino Airport7:10 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Wizz Air goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/12/2026 9:25:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 2/13/2026 7:10:00 AM. 50 Economy ticket for $147 per person are available. Travel duration is 9h 45m
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FlixBus20h 30m09:30 AMRomeTiburtina Bus Station6:00 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/12/2026 9:30:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 2/13/2026 6:00:00 AM. 50 Economy ticket for $70 per person are available. Travel duration is 20h 30m
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FlixBus20h 45m09:30 AMRomeTiburtina Bus Station6:15 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/12/2026 9:30:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 2/13/2026 6:15:00 AM. 50 Economy ticket for $70 per person are available. Travel duration is 20h 45m
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FlixBus23h 25m011:10 AMRomeAnagnina Bus Station10:35 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 2/12/2026 11:10:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 2/13/2026 10:35:00 AM. 50 Economy ticket for $69 per person are available. Travel duration is 23h 25m
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FlixBus24h 0m010:55 PMRomeTiburtina Bus Station10:55 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/12/2026 10:55:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 2/13/2026 10:55:00 PM. 50 Economy ticket for $69 per person are available. Travel duration is 24h 0m
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FlixBus27h 55m010:55 PMRomeTiburtina Bus Station2:50 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/12/2026 10:55:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 2/14/2026 2:50:00 AM. 50 Economy ticket for $69 per person are available. Travel duration is 27h 55m
Fastest Flights Thursday
Fastest Buses Thursday
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Smartwings2h 0m02:00 PMRome Fiumicino AirportRome Fiumicino Airport4:00 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Smartwings goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/13/2026 2:00:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 2/13/2026 4:00:00 PM. 50 Economy ticket for $89 per person are available. Travel duration is 2h 0m
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Skyscanner5h 40m04:25 PMRome Ciampino AirportRome Ciampino Airport10:05 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Skyscanner goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 2/13/2026 4:25:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 2/13/2026 10:05:00 PM. 50 Economy ticket for $99 per person are available. Travel duration is 5h 40m
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Air Serbia12h 5m08:40 PMRome Fiumicino AirportRome Fiumicino Airport8:45 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Air Serbia goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/13/2026 8:40:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 2/14/2026 8:45:00 AM. 50 Economy ticket for $145 per person are available. Travel duration is 12h 5m
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Wizz Air13h 25m08:40 AMRome Fiumicino AirportRome Fiumicino Airport10:05 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Wizz Air goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/13/2026 8:40:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 2/13/2026 10:05:00 PM. 50 Economy ticket for $106 per person are available. Travel duration is 13h 25m
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Aegean Airlines23h 55m09:45 AMRome Fiumicino AirportRome Fiumicino Airport9:40 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Aegean Airlines goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 2/13/2026 9:45:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 2/14/2026 9:40:00 AM. 50 Economy ticket for $162 per person are available. Travel duration is 23h 55m
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FlixBus22h 45m011:50 AMRomeTiburtina Bus Station10:35 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/13/2026 11:50:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 2/14/2026 10:35:00 AM. 50 Economy ticket for $77 per person are available. Travel duration is 22h 45m
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FlixBus24h 50m05:00 PMRomeTiburtina Bus Station5:50 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/13/2026 5:00:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 2/14/2026 5:50:00 PM. 50 Economy ticket for $74 per person are available. Travel duration is 24h 50m
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FlixBus26h 55m05:25 PMRomeAnagnina Bus Station8:20 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 2/13/2026 5:25:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 2/14/2026 8:20:00 PM. 50 Economy ticket for $78 per person are available. Travel duration is 26h 55m
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FlixBus27h 0m05:00 PMRomeTiburtina Bus Station8:00 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 2/13/2026 5:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 2/14/2026 8:00:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 27h 0m
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FlixBus27h 5m01:05 PMRomeAnagnina Bus Station4:10 PMPragueČerný Most0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 2/13/2026 1:05:00 PM to Černý Most, Prague (Czech Republic) arriving at 2/14/2026 4:10:00 PM. 50 Economy ticket for $74 per person are available. Travel duration is 27h 5m
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Here you will find all operators and timetables for a
Bus from Rome to Prague
What are the most popular stations in Rome and Prague?
In Rome, you will usually depart from Termini Bus Station, Termini Central Station or Ostiense Train Station, while in Prague you will be arriving at Wilsonova Bus Station, ÚAN Florenc or Černý Most, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Prague from Rome? With 9 connections between 1 Flight and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Rome and Prague, you can pay as low as $35 with a Flight from LC Perú.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from Skyscanner: you will get to Prague in just 1h 50m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Rome and Prague are FlixBus, Skyscanner and Wizz Air, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Rome and Prague is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Settebagni or to Horoměřice, and look at flights from Rome Ciampino Airport, and landing at Prague Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Rome to Prague?
The most popular companies between Rome and Prague, are FlixBus, Skyscanner and Wizz Air. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus
Airlines: Skyscanner, Wizz Air, EasyJet Airline and 12 more.
All you need to know when you travel from Rome to Prague
Check all information on comfort and services on all modes of transports from Rome to Prague. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Rome to Prague
How can I reach Prague from Rome?
Every day, there are on average 9 connections between Flight and Bus, with which you can get to Prague from Rome.
How far is Prague from Rome?
The distance between Rome and Prague is 572.5 miles.
What is the most ecofriendly mode of transport between Rome and Prague?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 25 kgs of CO2, a train 32 kgs, a car 157 kgs, and a flight 227 kgs.
What is the cheapest mode of transport from Rome to Prague?
You can get to Prague with just $35 by taking a Flight from LC Perú.
What is the fastest way to get from Rome to Prague?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Prague in just 1h 50m with a Flight from Skyscanner.
More routes to Rome and to Prague
Looking for more options? Here you can see the most popular routes to Rome and to Prague. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Rome
- Avellino to Rome
- Bari to Rome
- Battipaglia to Rome
- Caserta to Rome
- Cassino to Rome
- Catanzaro to Rome
- Chieti to Rome
- Civitanova to Rome
- Grottaminarda to Rome
- L'Aquila to Rome
- Lamezia Terme to Rome
- Lecce to Rome
- Marseille to Rome
- Milan to Rome
- Mosciano Sant'Angelo to Rome
- Naples to Rome
- Perugia to Rome
- Pescara to Rome
- Potenza to Rome
- Rome Fiumicino Airport to Rome
- Sala Consilina to Rome
- Salerno to Rome
- San Benedetto del Tronto to Rome
- Venice to Rome
- Trips to Prague
- Amsterdam to Prague
- Berlin Brandenburg Airport to Prague
- Bern to Prague
- Bologna to Prague
- Bratislava to Prague
- Brno to Prague
- Brussels to Prague
- Florence to Prague
- Hamburg to Prague
- Heidelberg to Prague
- Hradec Kralove to Prague
- Jihlava to Prague
- Karlovy Vary to Prague
- Katowice to Prague
- Kosice to Prague
- Linz to Prague
- Munich Airport to Prague
- Nuremberg to Prague
- Paris to Prague
- Pilsen to Prague
- St. Gallen to Prague
- Třebíč to Prague
- Warsaw to Prague
- Wroclaw to Prague
