What is the best way to travel from Rome to Prague?
Looking for a trip? Compare all the available Buses and Flights for the journey to Prague from Rome. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
What is the cheapest way to reach Prague from Rome?
You can get to Prague with just $84 by taking a Bus from RegioJet, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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FlixBus20h 45m05:05 PMRomeTiburtina Bus Station1:50 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/26/2025 5:05:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 6/27/2025 1:50:00 PM. 50 Economy ticket for $100 per person are available. Travel duration is 20h 45m
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FlixBus20h 35m05:05 PMRomeTiburtina Bus Station1:40 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/26/2025 5:05:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/27/2025 1:40:00 PM. 50 Economy ticket for $100 per person are available. Travel duration is 20h 35m
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FlixBus25h 15m09:00 PMRomeTiburtina Bus Station10:15 PMPragueRoztyly0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/26/2025 9:00:00 PM to Roztyly, Prague (Czech Republic) arriving at 6/27/2025 10:15:00 PM. 50 Economy ticket for $103 per person are available. Travel duration is 25h 15m
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FlixBus26h 55m09:00 PMRomeTiburtina Bus Station11:55 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/26/2025 9:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/27/2025 11:55:00 PM. 50 Economy ticket for $103 per person are available. Travel duration is 26h 55m
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FlixBus23h 20m09:00 PMRomeTiburtina Bus Station8:20 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/26/2025 9:00:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 6/27/2025 8:20:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 23h 20m
Cheapest Buses Thursday
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FlixBus20h 45m05:05 PMRomeTiburtina Bus Station1:50 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/27/2025 5:05:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 6/28/2025 1:50:00 PM. 50 Economy ticket for $104 per person are available. Travel duration is 20h 45m
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FlixBus20h 35m05:05 PMRomeTiburtina Bus Station1:40 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/27/2025 5:05:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/28/2025 1:40:00 PM. 50 Economy ticket for $104 per person are available. Travel duration is 20h 35m
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FlixBus28h 5m010:55 PMRomeTiburtina Bus Station3:00 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/27/2025 10:55:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/29/2025 3:00:00 AM. 50 Economy ticket for $120 per person are available. Travel duration is 28h 5m
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FlixBus23h 20m09:00 PMRomeTiburtina Bus Station8:20 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/27/2025 9:00:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 6/28/2025 8:20:00 PM. 50 Economy ticket for $121 per person are available. Travel duration is 23h 20m
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FlixBus20h 40m09:00 PMRomeTiburtina Bus Station5:40 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/27/2025 9:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 6/28/2025 5:40:00 PM. 50 Economy ticket for $121 per person are available. Travel duration is 20h 40m
Cheapest Buses Friday
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FlixBus20h 45m05:05 PMRomeTiburtina Bus Station1:50 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/28/2025 5:05:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 6/29/2025 1:50:00 PM. 50 Economy ticket for $113 per person are available. Travel duration is 20h 45m
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FlixBus20h 35m05:05 PMRomeTiburtina Bus Station1:40 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/28/2025 5:05:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/29/2025 1:40:00 PM. 50 Economy ticket for $113 per person are available. Travel duration is 20h 35m
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FlixBus23h 20m09:00 PMRomeTiburtina Bus Station8:20 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/28/2025 9:00:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 6/29/2025 8:20:00 PM. 50 Economy ticket for $118 per person are available. Travel duration is 23h 20m
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FlixBus20h 35m010:55 PMRomeTiburtina Bus Station7:30 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/28/2025 10:55:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 6/29/2025 7:30:00 PM. 50 Economy ticket for $118 per person are available. Travel duration is 20h 35m
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FlixBus20h 25m010:55 PMRomeTiburtina Bus Station7:20 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/28/2025 10:55:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/29/2025 7:20:00 PM. 50 Economy ticket for $118 per person are available. Travel duration is 20h 25m
Cheapest Buses Saturday
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RegioJet20h 10m01:00 PMRomeTiburtina Bus Station9:10 AMPragueÚAN Florenc0EconomyA Bus from RegioJet goes from Tiburtina Bus Station, Rome (Italy) at 6/29/2025 1:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 6/30/2025 9:10:00 AM. 50 Economy ticket for $93 per person are available. Travel duration is 20h 10m
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RegioJet20h 39m01:00 PMRomeTiburtina Bus Station9:39 AMPragueWilsonova Bus Station0EconomyA Bus from RegioJet goes from Tiburtina Bus Station, Rome (Italy) at 6/29/2025 1:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/30/2025 9:39:00 AM. 50 Economy ticket for $110 per person are available. Travel duration is 20h 39m
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FlixBus20h 40m09:00 PMRomeTiburtina Bus Station5:40 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/29/2025 9:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 6/30/2025 5:40:00 PM. 50 Economy ticket for $123 per person are available. Travel duration is 20h 40m
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FlixBus20h 30m09:00 PMRomeTiburtina Bus Station5:30 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/29/2025 9:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/30/2025 5:30:00 PM. 50 Economy ticket for $123 per person are available. Travel duration is 20h 30m
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FlixBus23h 20m09:00 PMRomeTiburtina Bus Station8:20 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/29/2025 9:00:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 6/30/2025 8:20:00 PM. 50 Economy ticket for $127 per person are available. Travel duration is 23h 20m
Cheapest Buses Sunday
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FlixBus26h 55m09:00 PMRomeTiburtina Bus Station11:55 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/30/2025 9:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 7/1/2025 11:55:00 PM. 50 Economy ticket for $97 per person are available. Travel duration is 26h 55m
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FlixBus25h 15m09:00 PMRomeTiburtina Bus Station10:15 PMPragueRoztyly0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/30/2025 9:00:00 PM to Roztyly, Prague (Czech Republic) arriving at 7/1/2025 10:15:00 PM. 50 Economy ticket for $97 per person are available. Travel duration is 25h 15m
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FlixBus23h 20m09:00 PMRomeTiburtina Bus Station8:20 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/30/2025 9:00:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 7/1/2025 8:20:00 PM. 50 Economy ticket for $98 per person are available. Travel duration is 23h 20m
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FlixBus22h 30m010:15 AMRomeTiburtina Bus Station8:45 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/30/2025 10:15:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 7/1/2025 8:45:00 AM. 50 Economy ticket for $98 per person are available. Travel duration is 22h 30m
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FlixBus20h 40m09:00 PMRomeTiburtina Bus Station5:40 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/30/2025 9:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 7/1/2025 5:40:00 PM. 50 Economy ticket for $98 per person are available. Travel duration is 20h 40m
Cheapest Buses Monday
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FlixBus20h 45m05:05 PMRomeTiburtina Bus Station1:50 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 7/1/2025 5:05:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 7/2/2025 1:50:00 PM. 50 Economy ticket for $95 per person are available. Travel duration is 20h 45m
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FlixBus20h 35m05:05 PMRomeTiburtina Bus Station1:40 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 7/1/2025 5:05:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 7/2/2025 1:40:00 PM. 50 Economy ticket for $95 per person are available. Travel duration is 20h 35m
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FlixBus20h 40m09:00 PMRomeTiburtina Bus Station5:40 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 7/1/2025 9:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 7/2/2025 5:40:00 PM. 50 Economy ticket for $98 per person are available. Travel duration is 20h 40m
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FlixBus20h 30m09:00 PMRomeTiburtina Bus Station5:30 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 7/1/2025 9:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 7/2/2025 5:30:00 PM. 50 Economy ticket for $98 per person are available. Travel duration is 20h 30m
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FlixBus26h 55m09:00 PMRomeTiburtina Bus Station11:55 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 7/1/2025 9:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 7/2/2025 11:55:00 PM. 50 Economy ticket for $99 per person are available. Travel duration is 26h 55m
Cheapest Buses Tuesday
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RegioJet20h 10m01:00 PMRomeTiburtina Bus Station9:10 AMPragueÚAN Florenc0EconomyA Bus from RegioJet goes from Tiburtina Bus Station, Rome (Italy) at 7/2/2025 1:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 7/3/2025 9:10:00 AM. 50 Economy ticket for $84 per person are available. Travel duration is 20h 10m
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FlixBus20h 45m05:05 PMRomeTiburtina Bus Station1:50 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 7/2/2025 5:05:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 7/3/2025 1:50:00 PM. 50 Economy ticket for $92 per person are available. Travel duration is 20h 45m
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FlixBus20h 35m05:05 PMRomeTiburtina Bus Station1:40 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 7/2/2025 5:05:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 7/3/2025 1:40:00 PM. 50 Economy ticket for $92 per person are available. Travel duration is 20h 35m
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RegioJet20h 39m01:00 PMRomeTiburtina Bus Station9:39 AMPragueWilsonova Bus Station0EconomyA Bus from RegioJet goes from Tiburtina Bus Station, Rome (Italy) at 7/2/2025 1:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 7/3/2025 9:39:00 AM. 50 Economy ticket for $99 per person are available. Travel duration is 20h 39m
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FlixBus20h 40m09:00 PMRomeTiburtina Bus Station5:40 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 7/2/2025 9:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 7/3/2025 5:40:00 PM. 50 Economy ticket for $101 per person are available. Travel duration is 20h 40m
Cheapest Buses Wednesday
What are the fastest trips from Rome to Prague?
You can get to Prague from Rome in just 20h 10m with a Bus from RegioJet. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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FlixBus20h 35m05:05 PMRomeTiburtina Bus Station1:40 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/26/2025 5:05:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/27/2025 1:40:00 PM. 50 Economy ticket for $100 per person are available. Travel duration is 20h 35m
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FlixBus20h 45m05:05 PMRomeTiburtina Bus Station1:50 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/26/2025 5:05:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 6/27/2025 1:50:00 PM. 50 Economy ticket for $100 per person are available. Travel duration is 20h 45m
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FlixBus23h 20m09:00 PMRomeTiburtina Bus Station8:20 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/26/2025 9:00:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 6/27/2025 8:20:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 23h 20m
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FlixBus25h 15m09:00 PMRomeTiburtina Bus Station10:15 PMPragueRoztyly0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/26/2025 9:00:00 PM to Roztyly, Prague (Czech Republic) arriving at 6/27/2025 10:15:00 PM. 50 Economy ticket for $103 per person are available. Travel duration is 25h 15m
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FlixBus26h 55m09:00 PMRomeTiburtina Bus Station11:55 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/26/2025 9:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/27/2025 11:55:00 PM. 50 Economy ticket for $103 per person are available. Travel duration is 26h 55m
Fastest Buses Thursday
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FlixBus20h 35m05:05 PMRomeTiburtina Bus Station1:40 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/27/2025 5:05:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/28/2025 1:40:00 PM. 50 Economy ticket for $104 per person are available. Travel duration is 20h 35m
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FlixBus20h 40m09:00 PMRomeTiburtina Bus Station5:40 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/27/2025 9:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 6/28/2025 5:40:00 PM. 50 Economy ticket for $121 per person are available. Travel duration is 20h 40m
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FlixBus20h 45m05:05 PMRomeTiburtina Bus Station1:50 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/27/2025 5:05:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 6/28/2025 1:50:00 PM. 50 Economy ticket for $104 per person are available. Travel duration is 20h 45m
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FlixBus23h 20m09:00 PMRomeTiburtina Bus Station8:20 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/27/2025 9:00:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 6/28/2025 8:20:00 PM. 50 Economy ticket for $121 per person are available. Travel duration is 23h 20m
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FlixBus28h 5m010:55 PMRomeTiburtina Bus Station3:00 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/27/2025 10:55:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/29/2025 3:00:00 AM. 50 Economy ticket for $120 per person are available. Travel duration is 28h 5m
Fastest Buses Friday
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FlixBus20h 25m010:55 PMRomeTiburtina Bus Station7:20 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/28/2025 10:55:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/29/2025 7:20:00 PM. 50 Economy ticket for $118 per person are available. Travel duration is 20h 25m
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FlixBus20h 35m05:05 PMRomeTiburtina Bus Station1:40 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/28/2025 5:05:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/29/2025 1:40:00 PM. 50 Economy ticket for $113 per person are available. Travel duration is 20h 35m
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FlixBus20h 35m010:55 PMRomeTiburtina Bus Station7:30 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/28/2025 10:55:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 6/29/2025 7:30:00 PM. 50 Economy ticket for $118 per person are available. Travel duration is 20h 35m
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FlixBus20h 45m05:05 PMRomeTiburtina Bus Station1:50 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/28/2025 5:05:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 6/29/2025 1:50:00 PM. 50 Economy ticket for $113 per person are available. Travel duration is 20h 45m
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FlixBus23h 20m09:00 PMRomeTiburtina Bus Station8:20 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/28/2025 9:00:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 6/29/2025 8:20:00 PM. 50 Economy ticket for $118 per person are available. Travel duration is 23h 20m
Fastest Buses Saturday
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RegioJet20h 10m01:00 PMRomeTiburtina Bus Station9:10 AMPragueÚAN Florenc0EconomyA Bus from RegioJet goes from Tiburtina Bus Station, Rome (Italy) at 6/29/2025 1:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 6/30/2025 9:10:00 AM. 50 Economy ticket for $93 per person are available. Travel duration is 20h 10m
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FlixBus20h 30m09:00 PMRomeTiburtina Bus Station5:30 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/29/2025 9:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/30/2025 5:30:00 PM. 50 Economy ticket for $123 per person are available. Travel duration is 20h 30m
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RegioJet20h 39m01:00 PMRomeTiburtina Bus Station9:39 AMPragueWilsonova Bus Station0EconomyA Bus from RegioJet goes from Tiburtina Bus Station, Rome (Italy) at 6/29/2025 1:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 6/30/2025 9:39:00 AM. 50 Economy ticket for $110 per person are available. Travel duration is 20h 39m
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FlixBus20h 40m09:00 PMRomeTiburtina Bus Station5:40 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/29/2025 9:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 6/30/2025 5:40:00 PM. 50 Economy ticket for $123 per person are available. Travel duration is 20h 40m
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FlixBus23h 20m09:00 PMRomeTiburtina Bus Station8:20 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/29/2025 9:00:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 6/30/2025 8:20:00 PM. 50 Economy ticket for $127 per person are available. Travel duration is 23h 20m
Fastest Buses Sunday
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FlixBus20h 40m09:00 PMRomeTiburtina Bus Station5:40 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/30/2025 9:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 7/1/2025 5:40:00 PM. 50 Economy ticket for $98 per person are available. Travel duration is 20h 40m
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FlixBus22h 30m010:15 AMRomeTiburtina Bus Station8:45 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/30/2025 10:15:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 7/1/2025 8:45:00 AM. 50 Economy ticket for $98 per person are available. Travel duration is 22h 30m
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FlixBus23h 20m09:00 PMRomeTiburtina Bus Station8:20 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/30/2025 9:00:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 7/1/2025 8:20:00 PM. 50 Economy ticket for $98 per person are available. Travel duration is 23h 20m
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FlixBus25h 15m09:00 PMRomeTiburtina Bus Station10:15 PMPragueRoztyly0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/30/2025 9:00:00 PM to Roztyly, Prague (Czech Republic) arriving at 7/1/2025 10:15:00 PM. 50 Economy ticket for $97 per person are available. Travel duration is 25h 15m
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FlixBus26h 55m09:00 PMRomeTiburtina Bus Station11:55 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 6/30/2025 9:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 7/1/2025 11:55:00 PM. 50 Economy ticket for $97 per person are available. Travel duration is 26h 55m
Fastest Buses Monday
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FlixBus20h 30m09:00 PMRomeTiburtina Bus Station5:30 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 7/1/2025 9:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 7/2/2025 5:30:00 PM. 50 Economy ticket for $98 per person are available. Travel duration is 20h 30m
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FlixBus20h 35m05:05 PMRomeTiburtina Bus Station1:40 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 7/1/2025 5:05:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 7/2/2025 1:40:00 PM. 50 Economy ticket for $95 per person are available. Travel duration is 20h 35m
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FlixBus20h 40m09:00 PMRomeTiburtina Bus Station5:40 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 7/1/2025 9:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 7/2/2025 5:40:00 PM. 50 Economy ticket for $98 per person are available. Travel duration is 20h 40m
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FlixBus20h 45m05:05 PMRomeTiburtina Bus Station1:50 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 7/1/2025 5:05:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 7/2/2025 1:50:00 PM. 50 Economy ticket for $95 per person are available. Travel duration is 20h 45m
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FlixBus26h 55m09:00 PMRomeTiburtina Bus Station11:55 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 7/1/2025 9:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 7/2/2025 11:55:00 PM. 50 Economy ticket for $99 per person are available. Travel duration is 26h 55m
Fastest Buses Tuesday
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RegioJet20h 10m01:00 PMRomeTiburtina Bus Station9:10 AMPragueÚAN Florenc0EconomyA Bus from RegioJet goes from Tiburtina Bus Station, Rome (Italy) at 7/2/2025 1:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 7/3/2025 9:10:00 AM. 50 Economy ticket for $84 per person are available. Travel duration is 20h 10m
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FlixBus20h 35m05:05 PMRomeTiburtina Bus Station1:40 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 7/2/2025 5:05:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 7/3/2025 1:40:00 PM. 50 Economy ticket for $92 per person are available. Travel duration is 20h 35m
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RegioJet20h 39m01:00 PMRomeTiburtina Bus Station9:39 AMPragueWilsonova Bus Station0EconomyA Bus from RegioJet goes from Tiburtina Bus Station, Rome (Italy) at 7/2/2025 1:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 7/3/2025 9:39:00 AM. 50 Economy ticket for $99 per person are available. Travel duration is 20h 39m
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FlixBus20h 40m09:00 PMRomeTiburtina Bus Station5:40 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 7/2/2025 9:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 7/3/2025 5:40:00 PM. 50 Economy ticket for $101 per person are available. Travel duration is 20h 40m
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FlixBus20h 45m05:05 PMRomeTiburtina Bus Station1:50 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 7/2/2025 5:05:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 7/3/2025 1:50:00 PM. 50 Economy ticket for $92 per person are available. Travel duration is 20h 45m
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Here you will find all operators and timetables for a
Bus from Rome to Prague
What are the most popular stations in Rome and Prague?
In Rome, you will usually depart from Tiburtina Bus Station, Anagnina Bus Station or Termini Central Station, while in Prague you will be arriving at ÚAN Florenc, Train station Wilsonova or Holešovice zastávka Train Station, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Prague from Rome? With 5 connections between 2 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Rome and Prague, you can pay as low as $84 with a Bus from RegioJet.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Bus from RegioJet: you will get to Prague in just 20h 10m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Rome and Prague are FlixBus and RegioJet, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Rome and Prague is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Settebagni or to Horoměřice, and look at flights from Rome Ciampino Airport, and landing at Prague Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Rome to Prague?
The most popular companies between Rome and Prague, are FlixBus and RegioJet. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus and RegioJet
All you need to know when you travel from Rome to Prague
Check all information on comfort and services on all modes of transports from Rome to Prague. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Rome to Prague
How can I reach Prague from Rome?
Every day, there are on average 5 connections between Bus and Flight, with which you can get to Prague from Rome.
How far is Prague from Rome?
The distance between Rome and Prague is 572.5 miles.
What is the most ecofriendly mode of transport between Rome and Prague?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 25 kgs of CO2, a train 32 kgs, a car 157 kgs, and a flight 227 kgs.
What is the cheapest mode of transport from Rome to Prague?
You can get to Prague with just $84 by taking a Bus from RegioJet.
What is the fastest way to get from Rome to Prague?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Prague in just 20h 10m with a Bus from RegioJet.
More routes to Rome and to Prague
Looking for more options? Here you can see the most popular routes to Rome and to Prague. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Rome
- Alba Adriatica to Rome
- Avellino to Rome
- Battipaglia to Rome
- Bologna to Rome
- Brindisi to Rome
- Chieti to Rome
- Frascineto to Rome
- Grottaminarda to Rome
- L'Aquila to Rome
- Lamezia Terme to Rome
- Matera to Rome
- Messina to Rome
- Milan to Rome
- Mosciano Sant'Angelo to Rome
- Naples to Rome
- Perugia to Rome
- Pescara to Rome
- Potenza to Rome
- Rome Fiumicino Airport to Rome
- Sala Consilina to Rome
- Salerno to Rome
- San Benedetto del Tronto to Rome
- Teramo to Rome
- Vibo Valentia to Rome
- Trips to Prague
- Berlin to Prague
- Bonn to Prague
- Dresden to Prague
- Florence to Prague
- Frankfurt am Main Airport to Prague
- Frankfurt am Main to Prague
- Hamburg to Prague
- Hradec Kralove to Prague
- Humenne to Prague
- Istanbul to Prague
- Jihlava to Prague
- Katowice to Prague
- Kosice to Prague
- Krakow to Prague
- Linz to Prague
- Lyon to Prague
- Memmingen to Prague
- Munich to Prague
- Novy Jicin to Prague
- Povazska Bystrica to Prague
- Teplice to Prague
- Vienna to Prague
- Wroclaw to Prague
- Znojmo to Prague