What is the best way to travel from Rome to Prague?
Looking for a trip? Compare all the available Buses and Flights for the journey to Prague from Rome. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
What is the cheapest way to reach Prague from Rome?
You can get to Prague with just $68 by taking a Flight from LC Perú, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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FlixBus20h 45m05:05 PMRomeTiburtina Bus Station1:50 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/24/2025 5:05:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/25/2025 1:50:00 PM. 50 Economy ticket for $118 per person are available. Travel duration is 20h 45m
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FlixBus20h 35m05:05 PMRomeTiburtina Bus Station1:40 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/24/2025 5:05:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/25/2025 1:40:00 PM. 50 Economy ticket for $118 per person are available. Travel duration is 20h 35m
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FlixBus20h 45m09:00 PMRomeTiburtina Bus Station5:45 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/24/2025 9:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/25/2025 5:45:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 20h 45m
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FlixBus20h 30m09:00 PMRomeTiburtina Bus Station5:30 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/24/2025 9:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/25/2025 5:30:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 20h 30m
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FlixBus28h 30m05:25 PMRomeAnagnina Bus Station9:55 PMPragueČerný Most0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 12/24/2025 5:25:00 PM to Černý Most, Prague (Czech Republic) arriving at 12/25/2025 9:55:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 28h 30m
Cheapest Buses Wednesday
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LC Perú2h 0m06:40 AMRome Fiumicino AirportRome Fiumicino Airport8:40 AMPrague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/25/2025 6:40:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/25/2025 8:40:00 AM. 50 Economy ticket for $72 per person are available. Travel duration is 2h 0m
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Air Serbia23h 15m09:30 AMRome Fiumicino AirportRome Fiumicino Airport8:45 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Air Serbia goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/25/2025 9:30:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/26/2025 8:45:00 AM. 50 Economy ticket for $129 per person are available. Travel duration is 23h 15m
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Smartwings2h 0m02:00 PMRome Fiumicino AirportRome Fiumicino Airport4:00 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Smartwings goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/25/2025 2:00:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/25/2025 4:00:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 2h 0m
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LOT Polish Airlines / Polskie Linie Lotnicze5h 25m011:50 AMRome Fiumicino AirportRome Fiumicino Airport5:15 PMPrague AirportPrague Airport - T1/20EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/25/2025 11:50:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/25/2025 5:15:00 PM. 50 Economy ticket for $183 per person are available. Travel duration is 5h 25m
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ITA Airways10h 5m09:45 PMRome Fiumicino AirportRome Fiumicino Airport7:50 AMPrague AirportPrague Airport - T1/20EconomyA Flight from ITA Airways goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/25/2025 9:45:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/26/2025 7:50:00 AM. 50 Economy ticket for $210 per person are available. Travel duration is 10h 5m
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FlixBus22h 40m010:45 AMRome Ciampino AirportRome Ciampino Airport9:25 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 12/25/2025 10:45:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/26/2025 9:25:00 AM. 50 Economy ticket for $127 per person are available. Travel duration is 22h 40m
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FlixBus24h 35m011:10 AMRomeAnagnina Bus Station11:45 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 12/25/2025 11:10:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 12/26/2025 11:45:00 AM. 50 Economy ticket for $139 per person are available. Travel duration is 24h 35m
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FlixBus23h 50m010:45 AMRome Ciampino AirportRome Ciampino Airport10:35 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 12/25/2025 10:45:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/26/2025 10:35:00 AM. 50 Economy ticket for $140 per person are available. Travel duration is 23h 50m
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FlixBus22h 45m011:50 AMRomeTiburtina Bus Station10:35 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/25/2025 11:50:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/26/2025 10:35:00 AM. 50 Economy ticket for $140 per person are available. Travel duration is 22h 45m
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FlixBus25h 20m010:10 AMRomeTiburtina Bus Station11:30 AMPragueZličín0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/25/2025 10:10:00 AM to Zličín, Prague (Czech Republic) arriving at 12/26/2025 11:30:00 AM. 50 Economy ticket for $140 per person are available. Travel duration is 25h 20m
Cheapest Flights Thursday
Cheapest Buses Thursday
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FlixBus20h 45m05:05 PMRomeTiburtina Bus Station1:50 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/26/2025 5:05:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/27/2025 1:50:00 PM. 50 Economy ticket for $137 per person are available. Travel duration is 20h 45m
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FlixBus20h 35m05:05 PMRomeTiburtina Bus Station1:40 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/26/2025 5:05:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/27/2025 1:40:00 PM. 50 Economy ticket for $137 per person are available. Travel duration is 20h 35m
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FlixBus25h 25m010:45 AMRome Ciampino AirportRome Ciampino Airport12:10 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 12/26/2025 10:45:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/27/2025 12:10:00 PM. 50 Economy ticket for $145 per person are available. Travel duration is 25h 25m
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FlixBus30h 0m03:30 PMRome Ciampino AirportRome Ciampino Airport9:30 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 12/26/2025 3:30:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/27/2025 9:30:00 PM. 50 Economy ticket for $147 per person are available. Travel duration is 30h 0m
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FlixBus30h 50m010:45 AMRome Ciampino AirportRome Ciampino Airport5:35 PMPragueHradčanská0EconomyA Bus from FlixBus goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 12/26/2025 10:45:00 AM to Hradčanská, Prague (Czech Republic) arriving at 12/27/2025 5:35:00 PM. 50 Economy ticket for $149 per person are available. Travel duration is 30h 50m
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Air Serbia11h 55m08:40 PMRome Fiumicino AirportRome Fiumicino Airport8:35 AMPrague AirportPrague Airport0EconomyA Flight from Air Serbia goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/26/2025 8:40:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 12/27/2025 8:35:00 AM. 50 Economy ticket for $150 per person are available. Travel duration is 11h 55m
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ITA Airways12h 25m08:10 PMRome Fiumicino AirportRome Fiumicino Airport8:35 AMPrague AirportPrague Airport0EconomyA Flight from ITA Airways goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/26/2025 8:10:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 12/27/2025 8:35:00 AM. 50 Economy ticket for $202 per person are available. Travel duration is 12h 25m
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EasyJet Airline8h 45m08:40 AMRome Fiumicino AirportRome Fiumicino Airport5:25 PMPrague AirportPrague Airport0EconomyA Flight from EasyJet Airline goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/26/2025 8:40:00 AM to Prague Airport, Prague Airport (Czech Republic) arriving at 12/26/2025 5:25:00 PM. 50 Economy ticket for $208 per person are available. Travel duration is 8h 45m
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Volotea25h 0m08:10 PMRome Fiumicino AirportRome Fiumicino Airport9:10 PMPrague AirportPrague Airport0EconomyA Flight from Volotea goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/26/2025 8:10:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 12/27/2025 9:10:00 PM. 50 Economy ticket for $211 per person are available. Travel duration is 25h 0m
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Wizz Air17h 15m010:35 PMRome Fiumicino AirportRome Fiumicino Airport3:50 PMPrague AirportPrague Airport0EconomyA Flight from Wizz Air goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/26/2025 10:35:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 12/27/2025 3:50:00 PM. 50 Economy ticket for $218 per person are available. Travel duration is 17h 15m
Cheapest Buses Friday
Cheapest Flights Friday
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LC Perú2h 0m06:40 AMRome Fiumicino AirportRome Fiumicino Airport8:40 AMPrague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/27/2025 6:40:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/27/2025 8:40:00 AM. 50 Economy ticket for $68 per person are available. Travel duration is 2h 0m
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Skyscanner1h 50m06:00 AMRome Ciampino AirportRome Ciampino Airport7:50 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Skyscanner goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 12/27/2025 6:00:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/27/2025 7:50:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 1h 50m
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Buzz6h 35m08:35 AMRome Ciampino AirportRome Ciampino Airport3:10 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Buzz goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 12/27/2025 8:35:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/27/2025 3:10:00 PM. 50 Economy ticket for $82 per person are available. Travel duration is 6h 35m
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Wizz Air9h 50m09:25 PMRome Fiumicino AirportRome Fiumicino Airport7:15 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Wizz Air goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/27/2025 9:25:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/28/2025 7:15:00 AM. 50 Economy ticket for $96 per person are available. Travel duration is 9h 50m
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Lufthansa8h 5m02:20 PMRome Fiumicino AirportRome Fiumicino Airport10:25 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Lufthansa goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/27/2025 2:20:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/27/2025 10:25:00 PM. 50 Economy ticket for $165 per person are available. Travel duration is 8h 5m
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FlixBus22h 40m010:45 AMRome Ciampino AirportRome Ciampino Airport9:25 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 12/27/2025 10:45:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/28/2025 9:25:00 AM. 50 Economy ticket for $115 per person are available. Travel duration is 22h 40m
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FlixBus26h 45m010:45 AMRome Ciampino AirportRome Ciampino Airport1:30 PMPragueRoztyly0EconomyA Bus from FlixBus goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 12/27/2025 10:45:00 AM to Roztyly, Prague (Czech Republic) arriving at 12/28/2025 1:30:00 PM. 50 Economy ticket for $141 per person are available. Travel duration is 26h 45m
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FlixBus20h 35m05:05 PMRomeTiburtina Bus Station1:40 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/27/2025 5:05:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/28/2025 1:40:00 PM. 50 Economy ticket for $141 per person are available. Travel duration is 20h 35m
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FlixBus20h 45m05:05 PMRomeTiburtina Bus Station1:50 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/27/2025 5:05:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/28/2025 1:50:00 PM. 50 Economy ticket for $141 per person are available. Travel duration is 20h 45m
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FlixBus20h 30m09:00 PMRomeTiburtina Bus Station5:30 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/27/2025 9:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/28/2025 5:30:00 PM. 50 Economy ticket for $147 per person are available. Travel duration is 20h 30m
Cheapest Flights Saturday
Cheapest Buses Saturday
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LC Perú23h 45m010:15 PMRome Fiumicino AirportRome Fiumicino Airport10:00 PMPrague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/28/2025 10:15:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/29/2025 10:00:00 PM. 50 Economy ticket for $120 per person are available. Travel duration is 23h 45m
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Skyscanner5h 55m06:10 AMRome Fiumicino AirportRome Fiumicino Airport12:05 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Skyscanner goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/28/2025 6:10:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/28/2025 12:05:00 PM. 50 Economy ticket for $123 per person are available. Travel duration is 5h 55m
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Air Serbia11h 55m08:40 PMRome Fiumicino AirportRome Fiumicino Airport8:35 AMPrague AirportPrague Airport0EconomyA Flight from Air Serbia goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/28/2025 8:40:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 12/29/2025 8:35:00 AM. 50 Economy ticket for $131 per person are available. Travel duration is 11h 55m
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Ryanair16h 10m09:20 PMRome Ciampino AirportRome Ciampino Airport1:30 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Ryanair goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 12/28/2025 9:20:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/29/2025 1:30:00 PM. 50 Economy ticket for $137 per person are available. Travel duration is 16h 10m
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Buzz1h 50m08:35 AMRome Ciampino AirportRome Ciampino Airport10:25 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Buzz goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 12/28/2025 8:35:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/28/2025 10:25:00 AM. 50 Economy ticket for $144 per person are available. Travel duration is 1h 50m
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FlixBus22h 40m010:45 AMRome Ciampino AirportRome Ciampino Airport9:25 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 12/28/2025 10:45:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/29/2025 9:25:00 AM. 50 Economy ticket for $140 per person are available. Travel duration is 22h 40m
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FlixBus20h 35m05:05 PMRomeTiburtina Bus Station1:40 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/28/2025 5:05:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/29/2025 1:40:00 PM. 50 Economy ticket for $141 per person are available. Travel duration is 20h 35m
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FlixBus20h 45m05:05 PMRomeTiburtina Bus Station1:50 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/28/2025 5:05:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/29/2025 1:50:00 PM. 50 Economy ticket for $141 per person are available. Travel duration is 20h 45m
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FlixBus24h 25m01:05 PMRomeAnagnina Bus Station1:30 PMPragueRoztyly0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 12/28/2025 1:05:00 PM to Roztyly, Prague (Czech Republic) arriving at 12/29/2025 1:30:00 PM. 50 Economy ticket for $144 per person are available. Travel duration is 24h 25m
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FlixBus20h 30m09:30 AMRomeTiburtina Bus Station6:00 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/28/2025 9:30:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/29/2025 6:00:00 AM. 50 Economy ticket for $145 per person are available. Travel duration is 20h 30m
Cheapest Flights Sunday
Cheapest Buses Sunday
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LC Perú7h 30m02:30 PMRome Fiumicino AirportRome Fiumicino Airport10:00 PMPrague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/29/2025 2:30:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/29/2025 10:00:00 PM. 50 Economy ticket for $107 per person are available. Travel duration is 7h 30m
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Air Serbia23h 5m09:30 AMRome Fiumicino AirportRome Fiumicino Airport8:35 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Air Serbia goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/29/2025 9:30:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/30/2025 8:35:00 AM. 50 Economy ticket for $125 per person are available. Travel duration is 23h 5m
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Skyscanner12h 30m09:30 AMRome Fiumicino AirportRome Fiumicino Airport10:00 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Skyscanner goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/29/2025 9:30:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/29/2025 10:00:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 12h 30m
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Buzz11h 45m09:25 PMRome Ciampino AirportRome Ciampino Airport9:10 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Buzz goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 12/29/2025 9:25:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/30/2025 9:10:00 AM. 50 Economy ticket for $143 per person are available. Travel duration is 11h 45m
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Ryanair6h 45m011:30 AMRome Ciampino AirportRome Ciampino Airport6:15 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Ryanair goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 12/29/2025 11:30:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/29/2025 6:15:00 PM. 50 Economy ticket for $222 per person are available. Travel duration is 6h 45m
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FlixBus22h 45m011:50 AMRomeTiburtina Bus Station10:35 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/29/2025 11:50:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/30/2025 10:35:00 AM. 50 Economy ticket for $146 per person are available. Travel duration is 22h 45m
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FlixBus26h 55m09:00 PMRomeTiburtina Bus Station11:55 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/29/2025 9:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/30/2025 11:55:00 PM. 50 Economy ticket for $147 per person are available. Travel duration is 26h 55m
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FlixBus22h 45m05:25 PMRomeAnagnina Bus Station4:10 PMPragueČerný Most0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 12/29/2025 5:25:00 PM to Černý Most, Prague (Czech Republic) arriving at 12/30/2025 4:10:00 PM. 50 Economy ticket for $147 per person are available. Travel duration is 22h 45m
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FlixBus25h 15m09:00 PMRomeTiburtina Bus Station10:15 PMPragueRoztyly0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/29/2025 9:00:00 PM to Roztyly, Prague (Czech Republic) arriving at 12/30/2025 10:15:00 PM. 50 Economy ticket for $149 per person are available. Travel duration is 25h 15m
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FlixBus23h 20m09:00 PMRomeTiburtina Bus Station8:20 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/29/2025 9:00:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 12/30/2025 8:20:00 PM. 50 Economy ticket for $151 per person are available. Travel duration is 23h 20m
Cheapest Flights Monday
Cheapest Buses Monday
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RegioJet20h 10m01:00 PMRomeTiburtina Bus Station9:10 AMPragueÚAN Florenc0EconomyA Bus from RegioJet goes from Tiburtina Bus Station, Rome (Italy) at 12/30/2025 1:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/31/2025 9:10:00 AM. 50 Economy ticket for $106 per person are available. Travel duration is 20h 10m
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RegioJet20h 58m01:00 PMRomeTiburtina Bus Station9:58 AMPragueWilsonova Bus Station0EconomyA Bus from RegioJet goes from Tiburtina Bus Station, Rome (Italy) at 12/30/2025 1:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/31/2025 9:58:00 AM. 50 Economy ticket for $121 per person are available. Travel duration is 20h 58m
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FlixBus26h 55m09:00 PMRomeTiburtina Bus Station11:55 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/30/2025 9:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/31/2025 11:55:00 PM. 50 Economy ticket for $137 per person are available. Travel duration is 26h 55m
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FlixBus25h 15m09:00 PMRomeTiburtina Bus Station10:15 PMPragueRoztyly0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/30/2025 9:00:00 PM to Roztyly, Prague (Czech Republic) arriving at 12/31/2025 10:15:00 PM. 50 Economy ticket for $137 per person are available. Travel duration is 25h 15m
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FlixBus23h 20m09:00 PMRomeTiburtina Bus Station8:20 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/30/2025 9:00:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 12/31/2025 8:20:00 PM. 50 Economy ticket for $137 per person are available. Travel duration is 23h 20m
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LC Perú23h 45m010:15 PMRome Fiumicino AirportRome Fiumicino Airport10:00 PMPrague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/30/2025 10:15:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/31/2025 10:00:00 PM. 50 Economy ticket for $113 per person are available. Travel duration is 23h 45m
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Skyscanner18h 20m05:50 AMRome Fiumicino AirportRome Fiumicino Airport12:10 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Skyscanner goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/30/2025 5:50:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/31/2025 12:10:00 AM. 50 Economy ticket for $116 per person are available. Travel duration is 18h 20m
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ITA Airways27h 40m05:00 PMRome Fiumicino AirportRome Fiumicino Airport8:40 PMPrague AirportPrague Airport0EconomyA Flight from ITA Airways goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/30/2025 5:00:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 12/31/2025 8:40:00 PM. 50 Economy ticket for $194 per person are available. Travel duration is 27h 40m
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Israir30h 0m011:50 AMRome Fiumicino AirportRome Fiumicino Airport5:50 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Israir goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/30/2025 11:50:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/31/2025 5:50:00 PM. 50 Economy ticket for $252 per person are available. Travel duration is 30h 0m
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EasyJet Airline14h 35m06:20 AMRome Fiumicino AirportRome Fiumicino Airport8:55 PMPrague AirportPrague Airport0EconomyA Flight from EasyJet Airline goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/30/2025 6:20:00 AM to Prague Airport, Prague Airport (Czech Republic) arriving at 12/30/2025 8:55:00 PM. 50 Economy ticket for $260 per person are available. Travel duration is 14h 35m
Cheapest Buses Tuesday
Cheapest Flights Tuesday
What are the fastest trips from Rome to Prague?
You can get to Prague from Rome in just 1h 50m with a Flight from Skyscanner. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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FlixBus20h 30m09:00 PMRomeTiburtina Bus Station5:30 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/24/2025 9:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/25/2025 5:30:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 20h 30m
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FlixBus20h 35m05:05 PMRomeTiburtina Bus Station1:40 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/24/2025 5:05:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/25/2025 1:40:00 PM. 50 Economy ticket for $118 per person are available. Travel duration is 20h 35m
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FlixBus20h 45m05:05 PMRomeTiburtina Bus Station1:50 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/24/2025 5:05:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/25/2025 1:50:00 PM. 50 Economy ticket for $118 per person are available. Travel duration is 20h 45m
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FlixBus20h 45m09:00 PMRomeTiburtina Bus Station5:45 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/24/2025 9:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/25/2025 5:45:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 20h 45m
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FlixBus28h 30m05:25 PMRomeAnagnina Bus Station9:55 PMPragueČerný Most0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 12/24/2025 5:25:00 PM to Černý Most, Prague (Czech Republic) arriving at 12/25/2025 9:55:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 28h 30m
Fastest Buses Wednesday
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LC Perú2h 0m06:40 AMRome Fiumicino AirportRome Fiumicino Airport8:40 AMPrague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/25/2025 6:40:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/25/2025 8:40:00 AM. 50 Economy ticket for $72 per person are available. Travel duration is 2h 0m
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Smartwings2h 0m02:00 PMRome Fiumicino AirportRome Fiumicino Airport4:00 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Smartwings goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/25/2025 2:00:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/25/2025 4:00:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 2h 0m
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LOT Polish Airlines / Polskie Linie Lotnicze5h 25m011:50 AMRome Fiumicino AirportRome Fiumicino Airport5:15 PMPrague AirportPrague Airport - T1/20EconomyA Flight from LOT Polish Airlines / Polskie Linie Lotnicze goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/25/2025 11:50:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/25/2025 5:15:00 PM. 50 Economy ticket for $183 per person are available. Travel duration is 5h 25m
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ITA Airways10h 5m09:45 PMRome Fiumicino AirportRome Fiumicino Airport7:50 AMPrague AirportPrague Airport - T1/20EconomyA Flight from ITA Airways goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/25/2025 9:45:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/26/2025 7:50:00 AM. 50 Economy ticket for $210 per person are available. Travel duration is 10h 5m
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Air Serbia23h 15m09:30 AMRome Fiumicino AirportRome Fiumicino Airport8:45 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Air Serbia goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/25/2025 9:30:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/26/2025 8:45:00 AM. 50 Economy ticket for $129 per person are available. Travel duration is 23h 15m
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FlixBus22h 40m010:45 AMRome Ciampino AirportRome Ciampino Airport9:25 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 12/25/2025 10:45:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/26/2025 9:25:00 AM. 50 Economy ticket for $127 per person are available. Travel duration is 22h 40m
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FlixBus22h 45m011:50 AMRomeTiburtina Bus Station10:35 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/25/2025 11:50:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/26/2025 10:35:00 AM. 50 Economy ticket for $140 per person are available. Travel duration is 22h 45m
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FlixBus23h 50m010:45 AMRome Ciampino AirportRome Ciampino Airport10:35 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 12/25/2025 10:45:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/26/2025 10:35:00 AM. 50 Economy ticket for $140 per person are available. Travel duration is 23h 50m
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FlixBus24h 35m011:10 AMRomeAnagnina Bus Station11:45 AMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 12/25/2025 11:10:00 AM to Na Knížecí Station, Prague (Czech Republic) arriving at 12/26/2025 11:45:00 AM. 50 Economy ticket for $139 per person are available. Travel duration is 24h 35m
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FlixBus25h 20m010:10 AMRomeTiburtina Bus Station11:30 AMPragueZličín0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/25/2025 10:10:00 AM to Zličín, Prague (Czech Republic) arriving at 12/26/2025 11:30:00 AM. 50 Economy ticket for $140 per person are available. Travel duration is 25h 20m
Fastest Flights Thursday
Fastest Buses Thursday
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EasyJet Airline8h 45m08:40 AMRome Fiumicino AirportRome Fiumicino Airport5:25 PMPrague AirportPrague Airport0EconomyA Flight from EasyJet Airline goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/26/2025 8:40:00 AM to Prague Airport, Prague Airport (Czech Republic) arriving at 12/26/2025 5:25:00 PM. 50 Economy ticket for $208 per person are available. Travel duration is 8h 45m
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Air Serbia11h 55m08:40 PMRome Fiumicino AirportRome Fiumicino Airport8:35 AMPrague AirportPrague Airport0EconomyA Flight from Air Serbia goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/26/2025 8:40:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 12/27/2025 8:35:00 AM. 50 Economy ticket for $150 per person are available. Travel duration is 11h 55m
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ITA Airways12h 25m08:10 PMRome Fiumicino AirportRome Fiumicino Airport8:35 AMPrague AirportPrague Airport0EconomyA Flight from ITA Airways goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/26/2025 8:10:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 12/27/2025 8:35:00 AM. 50 Economy ticket for $202 per person are available. Travel duration is 12h 25m
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Wizz Air17h 15m010:35 PMRome Fiumicino AirportRome Fiumicino Airport3:50 PMPrague AirportPrague Airport0EconomyA Flight from Wizz Air goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/26/2025 10:35:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 12/27/2025 3:50:00 PM. 50 Economy ticket for $218 per person are available. Travel duration is 17h 15m
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Volotea25h 0m08:10 PMRome Fiumicino AirportRome Fiumicino Airport9:10 PMPrague AirportPrague Airport0EconomyA Flight from Volotea goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/26/2025 8:10:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 12/27/2025 9:10:00 PM. 50 Economy ticket for $211 per person are available. Travel duration is 25h 0m
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FlixBus20h 35m05:05 PMRomeTiburtina Bus Station1:40 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/26/2025 5:05:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/27/2025 1:40:00 PM. 50 Economy ticket for $137 per person are available. Travel duration is 20h 35m
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FlixBus20h 45m05:05 PMRomeTiburtina Bus Station1:50 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/26/2025 5:05:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/27/2025 1:50:00 PM. 50 Economy ticket for $137 per person are available. Travel duration is 20h 45m
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FlixBus25h 25m010:45 AMRome Ciampino AirportRome Ciampino Airport12:10 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 12/26/2025 10:45:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/27/2025 12:10:00 PM. 50 Economy ticket for $145 per person are available. Travel duration is 25h 25m
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FlixBus30h 0m03:30 PMRome Ciampino AirportRome Ciampino Airport9:30 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 12/26/2025 3:30:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/27/2025 9:30:00 PM. 50 Economy ticket for $147 per person are available. Travel duration is 30h 0m
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FlixBus30h 50m010:45 AMRome Ciampino AirportRome Ciampino Airport5:35 PMPragueHradčanská0EconomyA Bus from FlixBus goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 12/26/2025 10:45:00 AM to Hradčanská, Prague (Czech Republic) arriving at 12/27/2025 5:35:00 PM. 50 Economy ticket for $149 per person are available. Travel duration is 30h 50m
Fastest Flights Friday
Fastest Buses Friday
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Skyscanner1h 50m06:00 AMRome Ciampino AirportRome Ciampino Airport7:50 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Skyscanner goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 12/27/2025 6:00:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/27/2025 7:50:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 1h 50m
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LC Perú2h 0m06:40 AMRome Fiumicino AirportRome Fiumicino Airport8:40 AMPrague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/27/2025 6:40:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/27/2025 8:40:00 AM. 50 Economy ticket for $68 per person are available. Travel duration is 2h 0m
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Buzz6h 35m08:35 AMRome Ciampino AirportRome Ciampino Airport3:10 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Buzz goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 12/27/2025 8:35:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/27/2025 3:10:00 PM. 50 Economy ticket for $82 per person are available. Travel duration is 6h 35m
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Lufthansa8h 5m02:20 PMRome Fiumicino AirportRome Fiumicino Airport10:25 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Lufthansa goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/27/2025 2:20:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/27/2025 10:25:00 PM. 50 Economy ticket for $165 per person are available. Travel duration is 8h 5m
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Wizz Air9h 50m09:25 PMRome Fiumicino AirportRome Fiumicino Airport7:15 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Wizz Air goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/27/2025 9:25:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/28/2025 7:15:00 AM. 50 Economy ticket for $96 per person are available. Travel duration is 9h 50m
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FlixBus20h 30m09:00 PMRomeTiburtina Bus Station5:30 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/27/2025 9:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/28/2025 5:30:00 PM. 50 Economy ticket for $147 per person are available. Travel duration is 20h 30m
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FlixBus20h 35m05:05 PMRomeTiburtina Bus Station1:40 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/27/2025 5:05:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/28/2025 1:40:00 PM. 50 Economy ticket for $141 per person are available. Travel duration is 20h 35m
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FlixBus20h 45m05:05 PMRomeTiburtina Bus Station1:50 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/27/2025 5:05:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/28/2025 1:50:00 PM. 50 Economy ticket for $141 per person are available. Travel duration is 20h 45m
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FlixBus22h 40m010:45 AMRome Ciampino AirportRome Ciampino Airport9:25 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 12/27/2025 10:45:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/28/2025 9:25:00 AM. 50 Economy ticket for $115 per person are available. Travel duration is 22h 40m
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FlixBus26h 45m010:45 AMRome Ciampino AirportRome Ciampino Airport1:30 PMPragueRoztyly0EconomyA Bus from FlixBus goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 12/27/2025 10:45:00 AM to Roztyly, Prague (Czech Republic) arriving at 12/28/2025 1:30:00 PM. 50 Economy ticket for $141 per person are available. Travel duration is 26h 45m
Fastest Flights Saturday
Fastest Buses Saturday
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Buzz1h 50m08:35 AMRome Ciampino AirportRome Ciampino Airport10:25 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Buzz goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 12/28/2025 8:35:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/28/2025 10:25:00 AM. 50 Economy ticket for $144 per person are available. Travel duration is 1h 50m
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Skyscanner5h 55m06:10 AMRome Fiumicino AirportRome Fiumicino Airport12:05 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Skyscanner goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/28/2025 6:10:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/28/2025 12:05:00 PM. 50 Economy ticket for $123 per person are available. Travel duration is 5h 55m
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Air Serbia11h 55m08:40 PMRome Fiumicino AirportRome Fiumicino Airport8:35 AMPrague AirportPrague Airport0EconomyA Flight from Air Serbia goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/28/2025 8:40:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 12/29/2025 8:35:00 AM. 50 Economy ticket for $131 per person are available. Travel duration is 11h 55m
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Ryanair16h 10m09:20 PMRome Ciampino AirportRome Ciampino Airport1:30 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Ryanair goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 12/28/2025 9:20:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/29/2025 1:30:00 PM. 50 Economy ticket for $137 per person are available. Travel duration is 16h 10m
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LC Perú23h 45m010:15 PMRome Fiumicino AirportRome Fiumicino Airport10:00 PMPrague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/28/2025 10:15:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/29/2025 10:00:00 PM. 50 Economy ticket for $120 per person are available. Travel duration is 23h 45m
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FlixBus20h 30m09:30 AMRomeTiburtina Bus Station6:00 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/28/2025 9:30:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/29/2025 6:00:00 AM. 50 Economy ticket for $145 per person are available. Travel duration is 20h 30m
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FlixBus20h 35m05:05 PMRomeTiburtina Bus Station1:40 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/28/2025 5:05:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/29/2025 1:40:00 PM. 50 Economy ticket for $141 per person are available. Travel duration is 20h 35m
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FlixBus20h 45m05:05 PMRomeTiburtina Bus Station1:50 PMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/28/2025 5:05:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/29/2025 1:50:00 PM. 50 Economy ticket for $141 per person are available. Travel duration is 20h 45m
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FlixBus22h 40m010:45 AMRome Ciampino AirportRome Ciampino Airport9:25 AMPragueÚAN Florenc0EconomyA Bus from FlixBus goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 12/28/2025 10:45:00 AM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/29/2025 9:25:00 AM. 50 Economy ticket for $140 per person are available. Travel duration is 22h 40m
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FlixBus24h 25m01:05 PMRomeAnagnina Bus Station1:30 PMPragueRoztyly0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 12/28/2025 1:05:00 PM to Roztyly, Prague (Czech Republic) arriving at 12/29/2025 1:30:00 PM. 50 Economy ticket for $144 per person are available. Travel duration is 24h 25m
Fastest Flights Sunday
Fastest Buses Sunday
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Ryanair6h 45m011:30 AMRome Ciampino AirportRome Ciampino Airport6:15 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Ryanair goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 12/29/2025 11:30:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/29/2025 6:15:00 PM. 50 Economy ticket for $222 per person are available. Travel duration is 6h 45m
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LC Perú7h 30m02:30 PMRome Fiumicino AirportRome Fiumicino Airport10:00 PMPrague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/29/2025 2:30:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/29/2025 10:00:00 PM. 50 Economy ticket for $107 per person are available. Travel duration is 7h 30m
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Buzz11h 45m09:25 PMRome Ciampino AirportRome Ciampino Airport9:10 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Buzz goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 12/29/2025 9:25:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/30/2025 9:10:00 AM. 50 Economy ticket for $143 per person are available. Travel duration is 11h 45m
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Skyscanner12h 30m09:30 AMRome Fiumicino AirportRome Fiumicino Airport10:00 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Skyscanner goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/29/2025 9:30:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/29/2025 10:00:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 12h 30m
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Air Serbia23h 5m09:30 AMRome Fiumicino AirportRome Fiumicino Airport8:35 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Air Serbia goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/29/2025 9:30:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/30/2025 8:35:00 AM. 50 Economy ticket for $125 per person are available. Travel duration is 23h 5m
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FlixBus22h 45m011:50 AMRomeTiburtina Bus Station10:35 AMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/29/2025 11:50:00 AM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/30/2025 10:35:00 AM. 50 Economy ticket for $146 per person are available. Travel duration is 22h 45m
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FlixBus22h 45m05:25 PMRomeAnagnina Bus Station4:10 PMPragueČerný Most0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 12/29/2025 5:25:00 PM to Černý Most, Prague (Czech Republic) arriving at 12/30/2025 4:10:00 PM. 50 Economy ticket for $147 per person are available. Travel duration is 22h 45m
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FlixBus23h 20m09:00 PMRomeTiburtina Bus Station8:20 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/29/2025 9:00:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 12/30/2025 8:20:00 PM. 50 Economy ticket for $151 per person are available. Travel duration is 23h 20m
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FlixBus25h 15m09:00 PMRomeTiburtina Bus Station10:15 PMPragueRoztyly0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/29/2025 9:00:00 PM to Roztyly, Prague (Czech Republic) arriving at 12/30/2025 10:15:00 PM. 50 Economy ticket for $149 per person are available. Travel duration is 25h 15m
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FlixBus26h 55m09:00 PMRomeTiburtina Bus Station11:55 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/29/2025 9:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/30/2025 11:55:00 PM. 50 Economy ticket for $147 per person are available. Travel duration is 26h 55m
Fastest Flights Monday
Fastest Buses Monday
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EasyJet Airline14h 35m06:20 AMRome Fiumicino AirportRome Fiumicino Airport8:55 PMPrague AirportPrague Airport0EconomyA Flight from EasyJet Airline goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/30/2025 6:20:00 AM to Prague Airport, Prague Airport (Czech Republic) arriving at 12/30/2025 8:55:00 PM. 50 Economy ticket for $260 per person are available. Travel duration is 14h 35m
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Skyscanner18h 20m05:50 AMRome Fiumicino AirportRome Fiumicino Airport12:10 AMPrague AirportPrague Airport - T1/20EconomyA Flight from Skyscanner goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/30/2025 5:50:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/31/2025 12:10:00 AM. 50 Economy ticket for $116 per person are available. Travel duration is 18h 20m
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LC Perú23h 45m010:15 PMRome Fiumicino AirportRome Fiumicino Airport10:00 PMPrague AirportPrague Airport - T1/20EconomyA Flight from LC Perú goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/30/2025 10:15:00 PM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/31/2025 10:00:00 PM. 50 Economy ticket for $113 per person are available. Travel duration is 23h 45m
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ITA Airways27h 40m05:00 PMRome Fiumicino AirportRome Fiumicino Airport8:40 PMPrague AirportPrague Airport0EconomyA Flight from ITA Airways goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/30/2025 5:00:00 PM to Prague Airport, Prague Airport (Czech Republic) arriving at 12/31/2025 8:40:00 PM. 50 Economy ticket for $194 per person are available. Travel duration is 27h 40m
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Israir30h 0m011:50 AMRome Fiumicino AirportRome Fiumicino Airport5:50 PMPrague AirportPrague Airport - T1/20EconomyA Flight from Israir goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/30/2025 11:50:00 AM to Prague Airport - T1/2, Prague Airport (Czech Republic) arriving at 12/31/2025 5:50:00 PM. 50 Economy ticket for $252 per person are available. Travel duration is 30h 0m
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RegioJet20h 10m01:00 PMRomeTiburtina Bus Station9:10 AMPragueÚAN Florenc0EconomyA Bus from RegioJet goes from Tiburtina Bus Station, Rome (Italy) at 12/30/2025 1:00:00 PM to ÚAN Florenc, Prague (Czech Republic) arriving at 12/31/2025 9:10:00 AM. 50 Economy ticket for $106 per person are available. Travel duration is 20h 10m
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RegioJet20h 58m01:00 PMRomeTiburtina Bus Station9:58 AMPragueWilsonova Bus Station0EconomyA Bus from RegioJet goes from Tiburtina Bus Station, Rome (Italy) at 12/30/2025 1:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/31/2025 9:58:00 AM. 50 Economy ticket for $121 per person are available. Travel duration is 20h 58m
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FlixBus23h 20m09:00 PMRomeTiburtina Bus Station8:20 PMPragueNa Knížecí Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/30/2025 9:00:00 PM to Na Knížecí Station, Prague (Czech Republic) arriving at 12/31/2025 8:20:00 PM. 50 Economy ticket for $137 per person are available. Travel duration is 23h 20m
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FlixBus25h 15m09:00 PMRomeTiburtina Bus Station10:15 PMPragueRoztyly0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/30/2025 9:00:00 PM to Roztyly, Prague (Czech Republic) arriving at 12/31/2025 10:15:00 PM. 50 Economy ticket for $137 per person are available. Travel duration is 25h 15m
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FlixBus26h 55m09:00 PMRomeTiburtina Bus Station11:55 PMPragueWilsonova Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/30/2025 9:00:00 PM to Wilsonova Bus Station, Prague (Czech Republic) arriving at 12/31/2025 11:55:00 PM. 50 Economy ticket for $137 per person are available. Travel duration is 26h 55m
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Here you will find all operators and timetables for a
Bus from Rome to Prague
What are the most popular stations in Rome and Prague?
In Rome, you will usually depart from Termini Bus Station, Termini Central Station or Ostiense Train Station, while in Prague you will be arriving at Wilsonova Bus Station, ÚAN Florenc or Černý Most, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Prague from Rome? With 9 connections between 2 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Rome and Prague, you can pay as low as $68 with a Flight from LC Perú.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from Skyscanner: you will get to Prague in just 1h 50m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Rome and Prague are FlixBus, LC Perú and Air Serbia, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Rome and Prague is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Settebagni or to Horoměřice, and look at flights from Rome Ciampino Airport, and landing at Prague Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Rome to Prague?
The most popular companies between Rome and Prague, are FlixBus, LC Perú and Air Serbia. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus and RegioJet
Airlines: LC Perú, Air Serbia, Skyscanner and 10 more.
All you need to know when you travel from Rome to Prague
Check all information on comfort and services on all modes of transports from Rome to Prague. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Rome to Prague
How can I reach Prague from Rome?
Every day, there are on average 9 connections between Bus and Flight, with which you can get to Prague from Rome.
How far is Prague from Rome?
The distance between Rome and Prague is 572.5 miles.
What is the most ecofriendly mode of transport between Rome and Prague?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 25 kgs of CO2, a train 32 kgs, a car 157 kgs, and a flight 227 kgs.
What is the cheapest mode of transport from Rome to Prague?
You can get to Prague with just $68 by taking a Flight from LC Perú.
What is the fastest way to get from Rome to Prague?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Prague in just 1h 50m with a Flight from Skyscanner.
More routes to Rome and to Prague
Looking for more options? Here you can see the most popular routes to Rome and to Prague. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Rome
- Avellino to Rome
- Bari to Rome
- Battipaglia to Rome
- Catanzaro to Rome
- Chieti to Rome
- Civitanova to Rome
- Foggia to Rome
- Genoa to Rome
- Grottaminarda to Rome
- L'Aquila to Rome
- Lamezia Terme to Rome
- Lecce to Rome
- Milan to Rome
- Mosciano Sant'Angelo to Rome
- Naples to Rome
- Palermo to Rome
- Perugia to Rome
- Pescara to Rome
- Potenza to Rome
- Rome Fiumicino Airport to Rome
- Sala Consilina to Rome
- Salerno to Rome
- San Benedetto del Tronto to Rome
- Venice to Rome
- Trips to Prague
- Amsterdam to Prague
- Bern to Prague
- Bratislava to Prague
- Brno to Prague
- Chemnitz to Prague
- Dortmund to Prague
- Hamburg to Prague
- Jihlava to Prague
- Karlovy Vary to Prague
- Katowice to Prague
- Kosice to Prague
- Milan to Prague
- Nuremberg to Prague
- Olomouc to Prague
- Ostrava to Prague
- Paris to Prague
- Pilsen to Prague
- Prague Airport to Prague
- Presov to Prague
- Regensburg to Prague
- St. Gallen to Prague
- Třebíč to Prague
- Warsaw to Prague
- Wroclaw to Prague
