Bus Siena to Milan: Compare prices and save money

Compare all timetables for the bus from Siena to Milan

Here is a selection of the cheapest bus trips from the schedule from Siena to Milan from various bus operators like FlixBus or Itabus for the next days.

today

tomorrow

$14

Wednesday

Thursday

$19

Friday

$20

Saturday

$21

Sunday

$22

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	5h 15m	6:30 AM	Siena	Train Station	11:45 AM	Milan	San Donato Bus Station	Economy	$14	A Bus from FlixBus goes from Train Station, Siena (Italy) at 12/16/2025 6:30:00 AM to San Donato Bus Station, Milan (Italy) arriving at 12/16/2025 11:45:00 AM. 50 Economy ticket for $14 per person are available. Travel duration is 5h 15m
FlixBus	6h 35m	3:05 PM	Siena	Train Station	9:40 PM	Milan	Lampugnano Bus Station	Economy	$17	A Bus from FlixBus goes from Train Station, Siena (Italy) at 12/16/2025 3:05:00 PM to Lampugnano Bus Station, Milan (Italy) arriving at 12/16/2025 9:40:00 PM. 50 Economy ticket for $17 per person are available. Travel duration is 6h 35m
FlixBus	6h 49m	2:51 PM	Siena	Bus Stop	9:40 PM	Milan	Lampugnano Bus Station	Economy	$17	A Bus from FlixBus goes from Bus Stop, Siena (Italy) at 12/16/2025 2:51:00 PM to Lampugnano Bus Station, Milan (Italy) arriving at 12/16/2025 9:40:00 PM. 50 Economy ticket for $17 per person are available. Travel duration is 6h 49m
FlixBus	5h 45m	6:10 AM	Siena	Train Station	11:55 AM	Milan	Lampugnano Bus Station	Economy	$19	A Bus from FlixBus goes from Train Station, Siena (Italy) at 12/16/2025 6:10:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 12/16/2025 11:55:00 AM. 50 Economy ticket for $19 per person are available. Travel duration is 5h 45m
FlixBus	5h 50m	7:50 AM	Siena	Train Station	1:40 PM	Milan	Lampugnano Bus Station	Economy	$19	A Bus from FlixBus goes from Train Station, Siena (Italy) at 12/16/2025 7:50:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 12/16/2025 1:40:00 PM. 50 Economy ticket for $19 per person are available. Travel duration is 5h 50m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	5h 0m	7:45 PM	Siena	Train Station	12:45 AM	Milan	San Donato Bus Station	Economy	$19	A Bus from FlixBus goes from Train Station, Siena (Italy) at 12/18/2025 7:45:00 PM to San Donato Bus Station, Milan (Italy) arriving at 12/19/2025 12:45:00 AM. 50 Economy ticket for $19 per person are available. Travel duration is 5h 0m
FlixBus	5h 34m	7:45 PM	Siena	Train Station	1:19 AM	Milan	Lampugnano Bus Station	Economy	$19	A Bus from FlixBus goes from Train Station, Siena (Italy) at 12/18/2025 7:45:00 PM to Lampugnano Bus Station, Milan (Italy) arriving at 12/19/2025 1:19:00 AM. 50 Economy ticket for $19 per person are available. Travel duration is 5h 34m
FlixBus	5h 45m	6:10 AM	Siena	Train Station	11:55 AM	Milan	Lampugnano Bus Station	Economy	$20	A Bus from FlixBus goes from Train Station, Siena (Italy) at 12/18/2025 6:10:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 12/18/2025 11:55:00 AM. 50 Economy ticket for $20 per person are available. Travel duration is 5h 45m
FlixBus	7h 20m	2:25 PM	Siena	Train Station	9:45 PM	Milan	Lampugnano Bus Station	Economy	$21	A Bus from FlixBus goes from Train Station, Siena (Italy) at 12/18/2025 2:25:00 PM to Lampugnano Bus Station, Milan (Italy) arriving at 12/18/2025 9:45:00 PM. 50 Economy ticket for $21 per person are available. Travel duration is 7h 20m
FlixBus	7h 35m	11:20 AM	Siena	Train Station	6:55 PM	Milan	Lampugnano Bus Station	Economy	$22	A Bus from FlixBus goes from Train Station, Siena (Italy) at 12/18/2025 11:20:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 12/18/2025 6:55:00 PM. 50 Economy ticket for $22 per person are available. Travel duration is 7h 35m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	5h 0m	7:45 PM	Siena	Train Station	12:45 AM	Milan	San Donato Bus Station	Economy	$20	A Bus from FlixBus goes from Train Station, Siena (Italy) at 12/19/2025 7:45:00 PM to San Donato Bus Station, Milan (Italy) arriving at 12/20/2025 12:45:00 AM. 50 Economy ticket for $20 per person are available. Travel duration is 5h 0m
FlixBus	5h 45m	6:10 AM	Siena	Train Station	11:55 AM	Milan	Lampugnano Bus Station	Economy	$20	A Bus from FlixBus goes from Train Station, Siena (Italy) at 12/19/2025 6:10:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 12/19/2025 11:55:00 AM. 50 Economy ticket for $20 per person are available. Travel duration is 5h 45m
FlixBus	5h 34m	7:45 PM	Siena	Train Station	1:19 AM	Milan	Lampugnano Bus Station	Economy	$20	A Bus from FlixBus goes from Train Station, Siena (Italy) at 12/19/2025 7:45:00 PM to Lampugnano Bus Station, Milan (Italy) arriving at 12/20/2025 1:19:00 AM. 50 Economy ticket for $20 per person are available. Travel duration is 5h 34m
Itabus	6h 0m	6:35 PM	Siena	Train Station	12:35 AM	Milan	Lampugnano Bus Station	Premium Economy	$21	A Bus from Itabus goes from Train Station, Siena (Italy) at 12/19/2025 6:35:00 PM to Lampugnano Bus Station, Milan (Italy) arriving at 12/20/2025 12:35:00 AM. 50 Premium Economy ticket for $21 per person are available. Travel duration is 6h 0m
Itabus	5h 14m	6:35 PM	Siena	Train Station	11:49 PM	Milan	San Donato Bus Station	Premium Economy	$21	A Bus from Itabus goes from Train Station, Siena (Italy) at 12/19/2025 6:35:00 PM to San Donato Bus Station, Milan (Italy) arriving at 12/19/2025 11:49:00 PM. 50 Premium Economy ticket for $21 per person are available. Travel duration is 5h 14m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	4h 50m	4:05 PM	Siena	Train Station	8:55 PM	Milan	San Donato Bus Station	Economy	$21	A Bus from FlixBus goes from Train Station, Siena (Italy) at 12/20/2025 4:05:00 PM to San Donato Bus Station, Milan (Italy) arriving at 12/20/2025 8:55:00 PM. 50 Economy ticket for $21 per person are available. Travel duration is 4h 50m
FlixBus	5h 45m	6:10 AM	Siena	Train Station	11:55 AM	Milan	Lampugnano Bus Station	Economy	$21	A Bus from FlixBus goes from Train Station, Siena (Italy) at 12/20/2025 6:10:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 12/20/2025 11:55:00 AM. 50 Economy ticket for $21 per person are available. Travel duration is 5h 45m
FlixBus	7h 20m	2:25 PM	Siena	Train Station	9:45 PM	Milan	Lampugnano Bus Station	Economy	$22	A Bus from FlixBus goes from Train Station, Siena (Italy) at 12/20/2025 2:25:00 PM to Lampugnano Bus Station, Milan (Italy) arriving at 12/20/2025 9:45:00 PM. 50 Economy ticket for $22 per person are available. Travel duration is 7h 20m
Itabus	5h 14m	6:35 PM	Siena	Train Station	11:49 PM	Milan	San Donato Bus Station	Premium Economy	$70	A Bus from Itabus goes from Train Station, Siena (Italy) at 12/20/2025 6:35:00 PM to San Donato Bus Station, Milan (Italy) arriving at 12/20/2025 11:49:00 PM. 50 Premium Economy ticket for $70 per person are available. Travel duration is 5h 14m
Itabus	5h 50m	1:05 AM	Siena	Train Station	6:55 AM	Milan	Lampugnano Bus Station	Premium Economy	$70	A Bus from Itabus goes from Train Station, Siena (Italy) at 12/20/2025 1:05:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 12/20/2025 6:55:00 AM. 50 Premium Economy ticket for $70 per person are available. Travel duration is 5h 50m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	5h 45m	6:10 AM	Siena	Train Station	11:55 AM	Milan	Lampugnano Bus Station	Economy	$22	A Bus from FlixBus goes from Train Station, Siena (Italy) at 12/21/2025 6:10:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 12/21/2025 11:55:00 AM. 50 Economy ticket for $22 per person are available. Travel duration is 5h 45m
FlixBus	7h 20m	2:25 PM	Siena	Train Station	9:45 PM	Milan	Lampugnano Bus Station	Economy	$22	A Bus from FlixBus goes from Train Station, Siena (Italy) at 12/21/2025 2:25:00 PM to Lampugnano Bus Station, Milan (Italy) arriving at 12/21/2025 9:45:00 PM. 50 Economy ticket for $22 per person are available. Travel duration is 7h 20m
FlixBus	4h 50m	6:40 AM	Siena	Train Station	11:30 AM	Milan	San Donato Bus Station	Economy	$23	A Bus from FlixBus goes from Train Station, Siena (Italy) at 12/21/2025 6:40:00 AM to San Donato Bus Station, Milan (Italy) arriving at 12/21/2025 11:30:00 AM. 50 Economy ticket for $23 per person are available. Travel duration is 4h 50m
FlixBus	5h 0m	7:45 PM	Siena	Train Station	12:45 AM	Milan	San Donato Bus Station	Economy	$23	A Bus from FlixBus goes from Train Station, Siena (Italy) at 12/21/2025 7:45:00 PM to San Donato Bus Station, Milan (Italy) arriving at 12/22/2025 12:45:00 AM. 50 Economy ticket for $23 per person are available. Travel duration is 5h 0m
FlixBus	5h 34m	7:45 PM	Siena	Train Station	1:19 AM	Milan	Lampugnano Bus Station	Economy	$23	A Bus from FlixBus goes from Train Station, Siena (Italy) at 12/21/2025 7:45:00 PM to Lampugnano Bus Station, Milan (Italy) arriving at 12/22/2025 1:19:00 AM. 50 Economy ticket for $23 per person are available. Travel duration is 5h 34m

Did you know that if you travel from Siena to Milan via Florence, you can save more than $2? You can find the corresponding connections below.
- Distribusion
  
  5h 30m
  
  0
  
  4:50 PM
  
  Siena
  Train Station
  
  5:50 PM
  
  Florence
  Villa Costanza Bus Station
  
  0
  
  Basic
  
  $8
  
  A Bus from Distribusion goes from Train Station, Siena (Italy) at 12/16/2025 4:50:00 PM to Villa Costanza Bus Station, Florence (Italy) arriving at 12/16/2025 5:50:00 PM. 50 Basic ticket for $8 per person are available. Travel duration is 1h 0m
- FlixBus
  
  4h 10m
  
  0
  
  6:10 PM
  
  Florence
  Villa Costanza Bus Station
  
  10:20 PM
  
  Milan
  San Donato Bus Station
  
  0
  
  Economy
  
  $12
  
  A Bus from FlixBus goes from Villa Costanza Bus Station, Florence (Italy) at 12/16/2025 6:10:00 PM to San Donato Bus Station, Milan (Italy) arriving at 12/16/2025 10:20:00 PM. 50 Economy ticket for $12 per person are available. Travel duration is 4h 10m
Travel time is 0h 40m longer, but you will save $2

Best Price Offer: The price for the cheapest bus from Siena to Milan is $14 on 12/16/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between Siena and Milan

See here how frequent the connections between Siena and Milan are, during different times and days of the week.

Friday is the busiest day, with more than 59 daily buses from Siena to Milan. Tuesday has instead the fewest connections, with only 13 daily coaches between Siena and Milan.

The busiest time of the day is the Night, with 47 buses from Siena to Milan, while Afternoon sees the fewest connections between Siena and Milan, with 30 offers.

Facts about the bus from Siena to Milan

Compare all providers like FlixBus and Itabus that travel 30 times every day by bus from Siena to Milan in one click! Book your bus ticket from Siena to Milan starting from $14!

Cheapest Bus	$14
Fastest Bus	4h 30m
Earliest Bus	12:45 AM
Latest Bus	9:55 PM
Daily Bus Routes	30 Ø
Distance	182.3 miles
Bus Companies	FlixBus and Itabus

Cheapest bus connections from Siena to Milan

Every day, 30 buses from 2 bus companies leave Siena for Milan: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/15/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 12/14

Monday 12/15

Tuesday 12/16

$14

Wednesday 12/17

Thursday 12/18

$19

Friday 12/19

$20

Saturday 12/20

$70

Sunday 12/21

$22

Monday 12/22

Tuesday 12/23

$26

Wednesday 12/24

Thursday 12/25

Friday 12/26

Saturday 12/27

Sunday 12/28

$82

Monday 12/29

Tuesday 12/30

Wednesday 12/31

Thursday 01/01

Friday 01/02

Saturday 01/03

$27

Sunday 01/04

Monday 01/05

Tuesday 01/06

Wednesday 01/07

Thursday 01/08

Friday 01/09

$21

Saturday 01/10

The cheapest time to travel from Siena to Milan

See here on which day and which time of the day you can find the cheapest bus ticket from Siena to Milan, for the next 30 days.

With a price starting from $14, Tuesday is the cheapest day for a bus from Siena to Milan. Sunday instead is the most expensive day with prices starting from $22.

Morning is the cheapest day time for bus tickets from Siena to Milan, with $14. Evening is the most expensive time of the day with prices starting from $19.

How to save money travelling from Siena to Milan

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Siena to Milan in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Siena to Milan, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Siena to Milan are also emptier.

Beloved bus companies from Siena to Milan

These are the most booked bus companies between Siena to Milan from our users.

FlixBus from Siena to Milan

Here you will find the key facts about the FlixBus bus route Siena to Milan:

Cheapest Price	$14
Fastest Bus	4h 30m
Earliest Bus	12:45 AM
Last Bus	9:55 PM
Daily Connections	16 Ø
Found on	12/12/2025

Itabus from Siena to Milan

Here you will find the key facts about the Itabus bus route Siena to Milan:

Cheapest Price	$21
Fastest Bus	5h 14m
Earliest Bus	1:05 AM
Last Bus	6:35 PM
Daily Connections	34 Ø
Found on	11/22/2025

All bus stations and stops in Siena and Milan

In the map below, you can see where to find all bus stations in Siena and Milan.

Piazza Antonio Gramsci

Central Bus Station

Bus Stop

Viale Pietro Toselli 9

Colonna San Marco

Lampugnano Bus Station

Via Giulio Natta Lampugnano

Rogoredo Bus Station

Via Cassinis Giovanni Battista 76

San Donato Bus Station

Via Giuseppe Impastato 25

Central Station - Piazza Luigi di Savoia

Piazza Duca D'Aosta 16

Duomo Bus Stop

Piazza del Duomo

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Siena to Milan? Compare all modes of transports from Siena to Milan.

Service and Comfort on the bus from Siena to Milan

Want to know which seat classes are available on the buses from Siena to Milan? Or which bus companies serve the route Siena to Milan? Below you will find answers to your questions.

FAQs about the Siena to Milan bus

How much does a Siena Milan bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $14 and takes 5h 15m to reach Milan. Compare offers to save money!

How much could I save by comparing buses from Siena to Milan?

This route is offered by 2 companies with a range of ticket prices between $14 and $152. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Milan.

On average, how many connections are available from Siena to Milan each day?

Every day, the Siena to Milan bus route is served by approximately 30 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Siena to Milan take?

The fastest bus from Siena to Milan is offered by FlixBus and takes 4h 30m. Bus tickets for this connection cost $24. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Siena to Milan?

The earliest bus arriving in Milan from Siena starts at 12:45 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Siena to Milan?

The latest bus trip departing from Siena for Milan starts at 9:55 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Siena Milan route?

When traveling by bus from Siena to Milan, passengers can travel with FlixBus and Itabus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Siena and Milan?

You can check all the direct connections between Siena and Milan by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Itabus.

What can I take with me on the Siena to Milan bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Siena Milan bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Siena Milan bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Siena to Milan on your planned travel date.

How does CheckMyBus find the best bus deals from Siena to Milan?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 30 daily trips between Siena and Milan. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Siena to Milan?

Prices and availability for 30 trips between Siena and Milan change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Siena to Milan

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

Premium Economy

A mix between Economy and Business, it offers extra legroom, WI-FI and possible snacks.

More bus routes to Siena and to Milan

Here’s an overview of the most popular bus routes to Siena and to Milan. Simply click on the connection of your choice, and you will find all the details about your bus route!