What is the best way to travel from Siena to Milan?
Looking for a trip? Compare all the available Carpool, Buses and Trains for the journey to Milan from Siena. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 3 available companies to find your perfect trip!
What is the cheapest way to reach Milan from Siena?
You can get to Milan with just $8 by taking a Bus from FlixBus, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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FlixBus5h 55m07:50 AMSienaTrain Station1:45 PMMilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 9/24/2026 7:50:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 9/24/2026 1:45:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 5h 55m
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FlixBus6h 0m09:20 AMSienaTrain Station3:20 PMMilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 9/24/2026 9:20:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 9/24/2026 3:20:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 6h 0m
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FlixBus7h 25m011:30 AMSienaTrain Station6:55 PMMilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 9/24/2026 11:30:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 9/24/2026 6:55:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 7h 25m
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Itabus5h 45m010:55 AMSienaTrain Station4:40 PMMilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 9/24/2026 10:55:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 9/24/2026 4:40:00 PM. 50 Premium Economy ticket for $8 per person are available. Travel duration is 5h 45m
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Trenitalia5h 59m05:18 PMSienaTrain Station11:17 PMMilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 9/24/2026 5:18:00 PM to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 9/24/2026 11:17:00 PM. 50 Economy ticket for $30 per person are available. Travel duration is 5h 59m
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Trenitalia5h 36m05:41 PMSienaTrain Station11:17 PMMilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 9/24/2026 5:41:00 PM to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 9/24/2026 11:17:00 PM. 50 Economy ticket for $30 per person are available. Travel duration is 5h 36m
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Trenitalia6h 7m01:18 PMSienaTrain Station7:25 PMMilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 9/24/2026 1:18:00 PM to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 9/24/2026 7:25:00 PM. 50 Economy ticket for $33 per person are available. Travel duration is 6h 7m
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Trenitalia5h 54m05:18 PMSienaTrain Station11:12 PMMilanSan Giuliano Train Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 9/24/2026 5:18:00 PM to San Giuliano Train Station, Milan (Italy) arriving at 9/24/2026 11:12:00 PM. 50 Economy ticket for $35 per person are available. Travel duration is 5h 54m
Cheapest Buses Thursday
Cheapest Trains Thursday
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FlixBus4h 50m04:05 PMSienaTrain Station8:55 PMMilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 9/25/2026 4:05:00 PM to San Donato Bus Station, Milan (Italy) arriving at 9/25/2026 8:55:00 PM. 50 Economy ticket for $11 per person are available. Travel duration is 4h 50m
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FlixBus5h 19m06:40 PMSienaTrain Station11:59 PMMilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 9/25/2026 6:40:00 PM to Lampugnano Bus Station, Milan (Italy) arriving at 9/25/2026 11:59:00 PM. 50 Economy ticket for $12 per person are available. Travel duration is 5h 19m
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FlixBus5h 50m06:10 AMSienaTrain Station12:00 PMMilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 9/25/2026 6:10:00 AM to San Donato Bus Station, Milan (Italy) arriving at 9/25/2026 12:00:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 5h 50m
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Itabus5h 45m010:55 AMSienaTrain Station4:40 PMMilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 9/25/2026 10:55:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 9/25/2026 4:40:00 PM. 50 Premium Economy ticket for $15 per person are available. Travel duration is 5h 45m
Cheapest Buses Friday
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Itabus5h 45m010:55 AMSienaTrain Station4:40 PMMilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 9/26/2026 10:55:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 9/26/2026 4:40:00 PM. 50 Premium Economy ticket for $9 per person are available. Travel duration is 5h 45m
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Itabus5h 45m010:55 AMSienaPiazza Antonio Gramsci4:40 PMMilanLampugnano Bus Station0EconomyA Bus from Itabus goes from Piazza Antonio Gramsci, Siena (Italy) at 9/26/2026 10:55:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 9/26/2026 4:40:00 PM. 50 Economy ticket for $10 per person are available. Travel duration is 5h 45m
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Itabus4h 55m01:55 PMSienaCentral Bus Station6:50 PMMilanSan Donato Bus Station0EconomyA Bus from Itabus goes from Central Bus Station, Siena (Italy) at 9/26/2026 1:55:00 PM to San Donato Bus Station, Milan (Italy) arriving at 9/26/2026 6:50:00 PM. 50 Economy ticket for $11 per person are available. Travel duration is 4h 55m
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FlixBus4h 50m04:05 PMSienaTrain Station8:55 PMMilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 9/26/2026 4:05:00 PM to San Donato Bus Station, Milan (Italy) arriving at 9/26/2026 8:55:00 PM. 50 Economy ticket for $16 per person are available. Travel duration is 4h 50m
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Trenitalia6h 7m01:18 PMSienaTrain Station7:25 PMMilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 9/26/2026 1:18:00 PM to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 9/26/2026 7:25:00 PM. 50 Economy ticket for $30 per person are available. Travel duration is 6h 7m
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Trenitalia5h 59m05:18 PMSienaTrain Station11:17 PMMilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 9/26/2026 5:18:00 PM to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 9/26/2026 11:17:00 PM. 50 Economy ticket for $30 per person are available. Travel duration is 5h 59m
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Trenitalia5h 36m05:41 PMSienaTrain Station11:17 PMMilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 9/26/2026 5:41:00 PM to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 9/26/2026 11:17:00 PM. 50 Economy ticket for $30 per person are available. Travel duration is 5h 36m
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Trenitalia6h 42m03:18 PMSienaTrain Station10:00 PMMilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 9/26/2026 3:18:00 PM to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 9/26/2026 10:00:00 PM. 50 Economy ticket for $31 per person are available. Travel duration is 6h 42m
Cheapest Buses Saturday
Cheapest Trains Saturday
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Itabus5h 45m010:55 AMSienaPiazza Antonio Gramsci4:40 PMMilanLampugnano Bus Station0EconomyA Bus from Itabus goes from Piazza Antonio Gramsci, Siena (Italy) at 9/27/2026 10:55:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 9/27/2026 4:40:00 PM. 50 Economy ticket for $9 per person are available. Travel duration is 5h 45m
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Itabus5h 45m010:55 AMSienaTrain Station4:40 PMMilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 9/27/2026 10:55:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 9/27/2026 4:40:00 PM. 50 Premium Economy ticket for $15 per person are available. Travel duration is 5h 45m
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Itabus4h 55m01:55 PMSienaTrain Station6:50 PMMilanSan Donato Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 9/27/2026 1:55:00 PM to San Donato Bus Station, Milan (Italy) arriving at 9/27/2026 6:50:00 PM. 50 Premium Economy ticket for $25 per person are available. Travel duration is 4h 55m
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Itabus5h 50m01:05 AMSienaPiazza Antonio Gramsci6:55 AMMilanLampugnano Bus Station0EconomyA Bus from Itabus goes from Piazza Antonio Gramsci, Siena (Italy) at 9/27/2026 1:05:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 9/27/2026 6:55:00 AM. 50 Economy ticket for $26 per person are available. Travel duration is 5h 50m
Cheapest Buses Sunday
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FlixBus5h 50m06:10 AMSienaTrain Station12:00 PMMilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 9/28/2026 6:10:00 AM to San Donato Bus Station, Milan (Italy) arriving at 9/28/2026 12:00:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 5h 50m
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FlixBus5h 15m09:20 AMSienaTrain Station2:35 PMMilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 9/28/2026 9:20:00 AM to San Donato Bus Station, Milan (Italy) arriving at 9/28/2026 2:35:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 5h 15m
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FlixBus6h 50m06:10 AMSienaTrain Station1:00 PMMilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 9/28/2026 6:10:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 9/28/2026 1:00:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 6h 50m
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Itabus5h 45m010:55 AMSienaPiazza Antonio Gramsci4:40 PMMilanLampugnano Bus Station0EconomyA Bus from Itabus goes from Piazza Antonio Gramsci, Siena (Italy) at 9/28/2026 10:55:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 9/28/2026 4:40:00 PM. 50 Economy ticket for $9 per person are available. Travel duration is 5h 45m
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Trenitalia5h 59m05:18 PMSienaTrain Station11:17 PMMilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 9/28/2026 5:18:00 PM to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 9/28/2026 11:17:00 PM. 50 Economy ticket for $30 per person are available. Travel duration is 5h 59m
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Trenitalia5h 36m05:41 PMSienaTrain Station11:17 PMMilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 9/28/2026 5:41:00 PM to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 9/28/2026 11:17:00 PM. 50 Economy ticket for $30 per person are available. Travel duration is 5h 36m
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Trenitalia8h 9m06:36 AMSienaTrain Station2:45 PMMilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 9/28/2026 6:36:00 AM to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 9/28/2026 2:45:00 PM. 50 Economy ticket for $37 per person are available. Travel duration is 8h 9m
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Trenitalia6h 42m03:18 PMSienaTrain Station10:00 PMMilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 9/28/2026 3:18:00 PM to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 9/28/2026 10:00:00 PM. 50 Economy ticket for $37 per person are available. Travel duration is 6h 42m
Cheapest Buses Monday
Cheapest Trains Monday
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FlixBus4h 30m012:45 AMSienaTrain Station5:15 AMMilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 9/29/2026 12:45:00 AM to San Donato Bus Station, Milan (Italy) arriving at 9/29/2026 5:15:00 AM. 50 Economy ticket for $8 per person are available. Travel duration is 4h 30m
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FlixBus5h 50m06:10 AMSienaTrain Station12:00 PMMilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 9/29/2026 6:10:00 AM to San Donato Bus Station, Milan (Italy) arriving at 9/29/2026 12:00:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 5h 50m
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FlixBus5h 15m06:30 AMSienaTrain Station11:45 AMMilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 9/29/2026 6:30:00 AM to San Donato Bus Station, Milan (Italy) arriving at 9/29/2026 11:45:00 AM. 50 Economy ticket for $8 per person are available. Travel duration is 5h 15m
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Itabus5h 45m010:55 AMSienaTrain Station4:40 PMMilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 9/29/2026 10:55:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 9/29/2026 4:40:00 PM. 50 Premium Economy ticket for $19 per person are available. Travel duration is 5h 45m
Cheapest Buses Tuesday
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FlixBus5h 50m06:10 AMSienaTrain Station12:00 PMMilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 9/30/2026 6:10:00 AM to San Donato Bus Station, Milan (Italy) arriving at 9/30/2026 12:00:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 5h 50m
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FlixBus6h 50m06:10 AMSienaTrain Station1:00 PMMilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 9/30/2026 6:10:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 9/30/2026 1:00:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 6h 50m
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FlixBus5h 55m07:50 AMSienaTrain Station1:45 PMMilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 9/30/2026 7:50:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 9/30/2026 1:45:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 5h 55m
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Itabus5h 45m010:55 AMSienaTrain Station4:40 PMMilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 9/30/2026 10:55:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 9/30/2026 4:40:00 PM. 50 Premium Economy ticket for $8 per person are available. Travel duration is 5h 45m
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Trenitalia5h 59m05:18 PMSienaTrain Station11:17 PMMilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 9/30/2026 5:18:00 PM to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 9/30/2026 11:17:00 PM. 50 Economy ticket for $30 per person are available. Travel duration is 5h 59m
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Trenitalia5h 36m05:41 PMSienaTrain Station11:17 PMMilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 9/30/2026 5:41:00 PM to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 9/30/2026 11:17:00 PM. 50 Economy ticket for $30 per person are available. Travel duration is 5h 36m
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Trenitalia5h 47m06:25 AMSienaTrain Station12:12 PMMilanSan Giuliano Train Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 9/30/2026 6:25:00 AM to San Giuliano Train Station, Milan (Italy) arriving at 9/30/2026 12:12:00 PM. 50 Economy ticket for $30 per person are available. Travel duration is 5h 47m
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Trenitalia6h 42m03:18 PMSienaTrain Station10:00 PMMilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 9/30/2026 3:18:00 PM to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 9/30/2026 10:00:00 PM. 50 Economy ticket for $32 per person are available. Travel duration is 6h 42m
Cheapest Buses Wednesday
Cheapest Trains Wednesday
What are the fastest trips from Siena to Milan?
You can get to Milan from Siena in just 4h 30m with a Bus from FlixBus. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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Itabus4h 55m01:55 PMSienaTrain Station6:50 PMMilanSan Donato Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 9/24/2026 1:55:00 PM to San Donato Bus Station, Milan (Italy) arriving at 9/24/2026 6:50:00 PM. 50 Premium Economy ticket for $8 per person are available. Travel duration is 4h 55m
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Itabus5h 45m010:55 AMSienaTrain Station4:40 PMMilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 9/24/2026 10:55:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 9/24/2026 4:40:00 PM. 50 Premium Economy ticket for $8 per person are available. Travel duration is 5h 45m
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FlixBus5h 55m07:50 AMSienaTrain Station1:45 PMMilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 9/24/2026 7:50:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 9/24/2026 1:45:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 5h 55m
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FlixBus6h 0m09:20 AMSienaTrain Station3:20 PMMilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 9/24/2026 9:20:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 9/24/2026 3:20:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 6h 0m
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Trenitalia5h 36m05:41 PMSienaTrain Station11:17 PMMilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 9/24/2026 5:41:00 PM to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 9/24/2026 11:17:00 PM. 50 Economy ticket for $30 per person are available. Travel duration is 5h 36m
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Trenitalia5h 54m05:18 PMSienaTrain Station11:12 PMMilanSan Giuliano Train Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 9/24/2026 5:18:00 PM to San Giuliano Train Station, Milan (Italy) arriving at 9/24/2026 11:12:00 PM. 50 Economy ticket for $35 per person are available. Travel duration is 5h 54m
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Trenitalia5h 54m01:18 PMSienaTrain Station7:12 PMMilanSan Giuliano Train Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 9/24/2026 1:18:00 PM to San Giuliano Train Station, Milan (Italy) arriving at 9/24/2026 7:12:00 PM. 50 Economy ticket for $36 per person are available. Travel duration is 5h 54m
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Trenitalia5h 59m05:18 PMSienaTrain Station11:17 PMMilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 9/24/2026 5:18:00 PM to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 9/24/2026 11:17:00 PM. 50 Economy ticket for $30 per person are available. Travel duration is 5h 59m
Fastest Buses Thursday
Fastest Trains Thursday
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FlixBus4h 50m04:05 PMSienaTrain Station8:55 PMMilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 9/25/2026 4:05:00 PM to San Donato Bus Station, Milan (Italy) arriving at 9/25/2026 8:55:00 PM. 50 Economy ticket for $11 per person are available. Travel duration is 4h 50m
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Itabus4h 55m01:55 PMSienaTrain Station6:50 PMMilanSan Donato Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 9/25/2026 1:55:00 PM to San Donato Bus Station, Milan (Italy) arriving at 9/25/2026 6:50:00 PM. 50 Premium Economy ticket for $20 per person are available. Travel duration is 4h 55m
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FlixBus5h 19m06:40 PMSienaTrain Station11:59 PMMilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 9/25/2026 6:40:00 PM to Lampugnano Bus Station, Milan (Italy) arriving at 9/25/2026 11:59:00 PM. 50 Economy ticket for $12 per person are available. Travel duration is 5h 19m
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Itabus5h 45m010:55 AMSienaTrain Station4:40 PMMilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 9/25/2026 10:55:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 9/25/2026 4:40:00 PM. 50 Premium Economy ticket for $15 per person are available. Travel duration is 5h 45m
Fastest Buses Friday
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FlixBus4h 50m04:05 PMSienaTrain Station8:55 PMMilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 9/26/2026 4:05:00 PM to San Donato Bus Station, Milan (Italy) arriving at 9/26/2026 8:55:00 PM. 50 Economy ticket for $16 per person are available. Travel duration is 4h 50m
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Itabus4h 55m01:55 PMSienaCentral Bus Station6:50 PMMilanSan Donato Bus Station0EconomyA Bus from Itabus goes from Central Bus Station, Siena (Italy) at 9/26/2026 1:55:00 PM to San Donato Bus Station, Milan (Italy) arriving at 9/26/2026 6:50:00 PM. 50 Economy ticket for $11 per person are available. Travel duration is 4h 55m
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FlixBus5h 19m06:40 PMSienaTrain Station11:59 PMMilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 9/26/2026 6:40:00 PM to Lampugnano Bus Station, Milan (Italy) arriving at 9/26/2026 11:59:00 PM. 50 Economy ticket for $18 per person are available. Travel duration is 5h 19m
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Itabus5h 45m010:55 AMSienaTrain Station4:40 PMMilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 9/26/2026 10:55:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 9/26/2026 4:40:00 PM. 50 Premium Economy ticket for $9 per person are available. Travel duration is 5h 45m
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Trenitalia5h 36m05:41 PMSienaTrain Station11:17 PMMilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 9/26/2026 5:41:00 PM to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 9/26/2026 11:17:00 PM. 50 Economy ticket for $30 per person are available. Travel duration is 5h 36m
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Trenitalia5h 50m06:25 AMSienaTrain Station12:15 PMMilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 9/26/2026 6:25:00 AM to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 9/26/2026 12:15:00 PM. 50 Economy ticket for $32 per person are available. Travel duration is 5h 50m
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Trenitalia5h 59m05:18 PMSienaTrain Station11:17 PMMilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 9/26/2026 5:18:00 PM to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 9/26/2026 11:17:00 PM. 50 Economy ticket for $30 per person are available. Travel duration is 5h 59m
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Trenitalia6h 7m01:18 PMSienaTrain Station7:25 PMMilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 9/26/2026 1:18:00 PM to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 9/26/2026 7:25:00 PM. 50 Economy ticket for $30 per person are available. Travel duration is 6h 7m
Fastest Buses Saturday
Fastest Trains Saturday
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Itabus4h 55m01:55 PMSienaTrain Station6:50 PMMilanSan Donato Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 9/27/2026 1:55:00 PM to San Donato Bus Station, Milan (Italy) arriving at 9/27/2026 6:50:00 PM. 50 Premium Economy ticket for $25 per person are available. Travel duration is 4h 55m
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Itabus5h 45m010:55 AMSienaPiazza Antonio Gramsci4:40 PMMilanLampugnano Bus Station0EconomyA Bus from Itabus goes from Piazza Antonio Gramsci, Siena (Italy) at 9/27/2026 10:55:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 9/27/2026 4:40:00 PM. 50 Economy ticket for $9 per person are available. Travel duration is 5h 45m
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Itabus5h 45m010:55 AMSienaTrain Station4:40 PMMilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 9/27/2026 10:55:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 9/27/2026 4:40:00 PM. 50 Premium Economy ticket for $15 per person are available. Travel duration is 5h 45m
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Itabus5h 50m01:05 AMSienaPiazza Antonio Gramsci6:55 AMMilanLampugnano Bus Station0EconomyA Bus from Itabus goes from Piazza Antonio Gramsci, Siena (Italy) at 9/27/2026 1:05:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 9/27/2026 6:55:00 AM. 50 Economy ticket for $26 per person are available. Travel duration is 5h 50m
Fastest Buses Sunday
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FlixBus5h 15m09:20 AMSienaTrain Station2:35 PMMilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 9/28/2026 9:20:00 AM to San Donato Bus Station, Milan (Italy) arriving at 9/28/2026 2:35:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 5h 15m
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Itabus5h 45m010:55 AMSienaPiazza Antonio Gramsci4:40 PMMilanLampugnano Bus Station0EconomyA Bus from Itabus goes from Piazza Antonio Gramsci, Siena (Italy) at 9/28/2026 10:55:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 9/28/2026 4:40:00 PM. 50 Economy ticket for $9 per person are available. Travel duration is 5h 45m
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Itabus5h 45m010:55 AMSienaTrain Station4:40 PMMilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 9/28/2026 10:55:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 9/28/2026 4:40:00 PM. 50 Premium Economy ticket for $9 per person are available. Travel duration is 5h 45m
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FlixBus5h 50m06:10 AMSienaTrain Station12:00 PMMilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 9/28/2026 6:10:00 AM to San Donato Bus Station, Milan (Italy) arriving at 9/28/2026 12:00:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 5h 50m
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Trenitalia5h 36m05:41 PMSienaTrain Station11:17 PMMilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 9/28/2026 5:41:00 PM to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 9/28/2026 11:17:00 PM. 50 Economy ticket for $30 per person are available. Travel duration is 5h 36m
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Trenitalia5h 59m05:18 PMSienaTrain Station11:17 PMMilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 9/28/2026 5:18:00 PM to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 9/28/2026 11:17:00 PM. 50 Economy ticket for $30 per person are available. Travel duration is 5h 59m
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Trenitalia6h 41m04:41 PMSienaTrain Station11:22 PMMilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 9/28/2026 4:41:00 PM to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 9/28/2026 11:22:00 PM. 50 Economy ticket for $37 per person are available. Travel duration is 6h 41m
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Trenitalia6h 42m03:18 PMSienaTrain Station10:00 PMMilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 9/28/2026 3:18:00 PM to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 9/28/2026 10:00:00 PM. 50 Economy ticket for $37 per person are available. Travel duration is 6h 42m
Fastest Buses Monday
Fastest Trains Monday
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FlixBus4h 30m012:45 AMSienaTrain Station5:15 AMMilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 9/29/2026 12:45:00 AM to San Donato Bus Station, Milan (Italy) arriving at 9/29/2026 5:15:00 AM. 50 Economy ticket for $8 per person are available. Travel duration is 4h 30m
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FlixBus5h 15m06:30 AMSienaTrain Station11:45 AMMilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 9/29/2026 6:30:00 AM to San Donato Bus Station, Milan (Italy) arriving at 9/29/2026 11:45:00 AM. 50 Economy ticket for $8 per person are available. Travel duration is 5h 15m
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Itabus5h 45m010:55 AMSienaTrain Station4:40 PMMilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 9/29/2026 10:55:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 9/29/2026 4:40:00 PM. 50 Premium Economy ticket for $19 per person are available. Travel duration is 5h 45m
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Itabus5h 45m010:55 AMSienaPiazza Antonio Gramsci4:40 PMMilanLampugnano Bus Station0EconomyA Bus from Itabus goes from Piazza Antonio Gramsci, Siena (Italy) at 9/29/2026 10:55:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 9/29/2026 4:40:00 PM. 50 Economy ticket for $22 per person are available. Travel duration is 5h 45m
Fastest Buses Tuesday
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Trenitalia5h 36m05:41 PMSienaTrain Station11:17 PMMilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 9/30/2026 5:41:00 PM to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 9/30/2026 11:17:00 PM. 50 Economy ticket for $30 per person are available. Travel duration is 5h 36m
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Trenitalia5h 47m06:25 AMSienaTrain Station12:12 PMMilanSan Giuliano Train Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 9/30/2026 6:25:00 AM to San Giuliano Train Station, Milan (Italy) arriving at 9/30/2026 12:12:00 PM. 50 Economy ticket for $30 per person are available. Travel duration is 5h 47m
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Trenitalia5h 50m06:25 AMSienaTrain Station12:15 PMMilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 9/30/2026 6:25:00 AM to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 9/30/2026 12:15:00 PM. 50 Economy ticket for $33 per person are available. Travel duration is 5h 50m
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Trenitalia5h 59m05:18 PMSienaTrain Station11:17 PMMilanCentral Station - Piazza Luigi di Savoia0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 9/30/2026 5:18:00 PM to Central Station - Piazza Luigi di Savoia, Milan (Italy) arriving at 9/30/2026 11:17:00 PM. 50 Economy ticket for $30 per person are available. Travel duration is 5h 59m
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Itabus5h 45m010:55 AMSienaTrain Station4:40 PMMilanLampugnano Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 9/30/2026 10:55:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 9/30/2026 4:40:00 PM. 50 Premium Economy ticket for $8 per person are available. Travel duration is 5h 45m
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Itabus5h 45m010:55 AMSienaPiazza Antonio Gramsci4:40 PMMilanLampugnano Bus Station0EconomyA Bus from Itabus goes from Piazza Antonio Gramsci, Siena (Italy) at 9/30/2026 10:55:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 9/30/2026 4:40:00 PM. 50 Economy ticket for $9 per person are available. Travel duration is 5h 45m
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FlixBus5h 50m06:10 AMSienaTrain Station12:00 PMMilanSan Donato Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 9/30/2026 6:10:00 AM to San Donato Bus Station, Milan (Italy) arriving at 9/30/2026 12:00:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 5h 50m
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FlixBus5h 55m07:50 AMSienaTrain Station1:45 PMMilanLampugnano Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 9/30/2026 7:50:00 AM to Lampugnano Bus Station, Milan (Italy) arriving at 9/30/2026 1:45:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 5h 55m
Fastest Trains Wednesday
Fastest Buses Wednesday
Here you will find all operators and timetables for a
Bus from Siena to Milan
What are the most popular stations in Siena and Milan?
In Siena, you will usually depart from Central Bus Station, Bus Stop or Train Station, while in Milan you will be arriving at Central Station - Piazza Luigi di Savoia, Lampugnano Bus Station or Cadorna Train Station, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Milan from Siena? With 7 connections between 3 Carpool, Bus and Train operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Siena and Milan, you can pay as low as $8 with a Bus from FlixBus.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Bus from FlixBus: you will get to Milan in just 4h 30m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Siena and Milan are Trenitalia, Itabus and FlixBus, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Siena and Milan is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Castagno or to Corsico, and look at flights from , and landing at Bergamo Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Siena to Milan?
The most popular companies between Siena and Milan, are Trenitalia, Itabus and FlixBus. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Itabus and FlixBus
Train companies: Trenitalia
All you need to know when you travel from Siena to Milan
Check all information on comfort and services on all modes of transports from Siena to Milan. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Siena to Milan
How can I reach Milan from Siena?
Every day, there are on average 7 connections between Carpool, Bus and Train, with which you can get to Milan from Siena.
How far is Milan from Siena?
The distance between Siena and Milan is 182.3 miles.
What is the most ecofriendly mode of transport between Siena and Milan?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 8 kgs of CO2, a train 10 kgs, a car 50 kgs, and a flight 72 kgs.
What is the cheapest mode of transport from Siena to Milan?
You can get to Milan with just $8 by taking a Bus from FlixBus.
What is the fastest way to get from Siena to Milan?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Milan in just 4h 30m with a Bus from FlixBus.
More routes to Siena and to Milan
Looking for more options? Here you can see the most popular routes to Siena and to Milan. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Siena
- Assisi to Siena
- Avellino to Siena
- Bologna to Siena
- Caserta to Siena
- Cassino to Siena
- Chieti to Siena
- Fiumicino to Siena
- Florence to Siena
- Lucca to Siena
- Milan to Siena
- Naples to Siena
- Perugia to Siena
- Pescara to Siena
- Pisa to Siena
- Prato to Siena
- Rome to Siena
- Salerno to Siena
- Zurich to Siena
- Trips to Milan
- Aosta to Milan
- Basel to Milan
- Bologna to Milan
- Breuil-Cervinia to Milan
- Catania to Milan
- Cesenatico to Milan
- Chatillon to Milan
- Como to Milan
- Courmayeur to Milan
- Geneva to Milan
- Genoa to Milan
- Lyon to Milan
- Milan Linate Airport to Milan
- Milan Malpensa Airport to Milan
- Munich to Milan
- Paris Orly Airport to Milan
- Paris to Milan
- Pont-Saint-Martin to Milan
- Rimini to Milan
- Verona to Milan
- Verrès to Milan
- Villa San Giovanni to Milan
- Zurich to Milan
