What is the best way to travel from Indianapolis to San Diego?
Looking for a trip? Compare all the available Buses and Flights for the journey to San Diego from Indianapolis. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
What is the cheapest way to reach San Diego from Indianapolis?
You can get to San Diego with just $167 by taking a Flight from Frontier Airlines, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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United Airlines8h 53m05:45 AMIndianapolis AirportIndianapolis Airport11:38 AMSan Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/14/2025 5:45:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/14/2025 11:38:00 AM. 50 Economy ticket for $229 per person are available. Travel duration is 8h 53m
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Frontier Airlines6h 11m08:48 PMIndianapolis AirportIndianapolis Airport11:59 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/14/2025 8:48:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/14/2025 11:59:00 PM. 50 Economy ticket for $273 per person are available. Travel duration is 6h 11m
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Alaska Airlines7h 37m06:45 AMIndianapolis AirportIndianapolis Airport11:22 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/14/2025 6:45:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/14/2025 11:22:00 AM. 50 Economy ticket for $321 per person are available. Travel duration is 7h 37m
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American Airlines7h 31m07:22 PMIndianapolis AirportIndianapolis Airport11:53 PMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/14/2025 7:22:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/14/2025 11:53:00 PM. 50 Economy ticket for $321 per person are available. Travel duration is 7h 31m
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Spirit Airlines13h 2m08:48 AMIndianapolis AirportIndianapolis Airport6:50 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Spirit Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/14/2025 8:48:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/14/2025 6:50:00 PM. 50 Economy ticket for $452 per person are available. Travel duration is 13h 2m
Cheapest Flights Sunday
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Allegiant Air36h 53m08:00 AMIndianapolis AirportIndianapolis Airport5:53 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Allegiant Air goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/15/2025 8:00:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/16/2025 5:53:00 PM. 50 Economy ticket for $177 per person are available. Travel duration is 36h 53m
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United Airlines8h 53m05:45 AMIndianapolis AirportIndianapolis Airport11:38 AMSan Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/15/2025 5:45:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/15/2025 11:38:00 AM. 50 Economy ticket for $229 per person are available. Travel duration is 8h 53m
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Alaska Airlines17h 43m07:30 PMIndianapolis AirportIndianapolis Airport10:13 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/15/2025 7:30:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/16/2025 10:13:00 AM. 50 Economy ticket for $234 per person are available. Travel duration is 17h 43m
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American Airlines7h 28m05:26 AMIndianapolis AirportIndianapolis Airport9:54 AMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/15/2025 5:26:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/15/2025 9:54:00 AM. 50 Economy ticket for $321 per person are available. Travel duration is 7h 28m
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Spirit Airlines13h 2m08:48 AMIndianapolis AirportIndianapolis Airport6:50 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Spirit Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/15/2025 8:48:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/15/2025 6:50:00 PM. 50 Economy ticket for $382 per person are available. Travel duration is 13h 2m
Cheapest Flights Monday
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FlixBus56h 35m08:35 AMIndianapolisWashington / Delaware2:10 PMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/16/2025 8:35:00 AM to Old Town Transit Center, San Diego (USA) arriving at 12/18/2025 2:10:00 PM. 50 Economy ticket for $315 per person are available. Travel duration is 56h 35m
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FlixBus56h 5m08:35 AMIndianapolisWashington / Delaware1:40 PMSan DiegoLa Jolla Village0EconomyA Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/16/2025 8:35:00 AM to La Jolla Village, San Diego (USA) arriving at 12/18/2025 1:40:00 PM. 50 Economy ticket for $315 per person are available. Travel duration is 56h 5m
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FlixBus64h 40m08:35 AMIndianapolisWashington / Delaware10:15 PMSan DiegoSeaport Village0EconomyA Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/16/2025 8:35:00 AM to Seaport Village, San Diego (USA) arriving at 12/18/2025 10:15:00 PM. 50 Economy ticket for $316 per person are available. Travel duration is 64h 40m
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Greyhound US53h 45m011:25 AMIndianapolisCentral Bus Station2:10 PMSan DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/16/2025 11:25:00 AM to Old Town Transit Center, San Diego (USA) arriving at 12/18/2025 2:10:00 PM. 50 Economy ticket for $316 per person are available. Travel duration is 53h 45m
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Greyhound US53h 15m011:25 AMIndianapolisCentral Bus Station1:40 PMSan DiegoLa Jolla Village0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/16/2025 11:25:00 AM to La Jolla Village, San Diego (USA) arriving at 12/18/2025 1:40:00 PM. 50 Economy ticket for $317 per person are available. Travel duration is 53h 15m
Cheapest Buses Tuesday
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United Airlines9h 0m05:45 AMIndianapolis AirportIndianapolis Airport11:45 AMSan Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/18/2025 5:45:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/18/2025 11:45:00 AM. 50 Economy ticket for $229 per person are available. Travel duration is 9h 0m
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United Airlines6h 44m06:00 AMIndianapolis AirportIndianapolis Airport9:44 AMSan Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/18/2025 6:00:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/18/2025 9:44:00 AM. 50 Economy ticket for $229 per person are available. Travel duration is 6h 44m
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American Airlines7h 20m05:29 AMIndianapolis AirportIndianapolis Airport9:49 AMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/18/2025 5:29:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/18/2025 9:49:00 AM. 50 Economy ticket for $320 per person are available. Travel duration is 7h 20m
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Alaska Airlines7h 32m06:55 AMIndianapolis AirportIndianapolis Airport11:27 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/18/2025 6:55:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/18/2025 11:27:00 AM. 50 Economy ticket for $320 per person are available. Travel duration is 7h 32m
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Alaska Airlines7h 7m02:12 PMIndianapolis AirportIndianapolis Airport6:19 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/18/2025 2:12:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/18/2025 6:19:00 PM. 50 Economy ticket for $320 per person are available. Travel duration is 7h 7m
Cheapest Flights Thursday
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FlixBus56h 35m08:35 AMIndianapolisWashington / Delaware2:10 PMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/19/2025 8:35:00 AM to Old Town Transit Center, San Diego (USA) arriving at 12/21/2025 2:10:00 PM. 50 Economy ticket for $329 per person are available. Travel duration is 56h 35m
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FlixBus56h 5m08:35 AMIndianapolisWashington / Delaware1:40 PMSan DiegoLa Jolla Village0EconomyA Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/19/2025 8:35:00 AM to La Jolla Village, San Diego (USA) arriving at 12/21/2025 1:40:00 PM. 50 Economy ticket for $329 per person are available. Travel duration is 56h 5m
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Greyhound US53h 15m011:25 AMIndianapolisCentral Bus Station1:40 PMSan DiegoLa Jolla Village0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/19/2025 11:25:00 AM to La Jolla Village, San Diego (USA) arriving at 12/21/2025 1:40:00 PM. 50 Economy ticket for $346 per person are available. Travel duration is 53h 15m
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Greyhound US53h 45m011:25 AMIndianapolisCentral Bus Station2:10 PMSan DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/19/2025 11:25:00 AM to Old Town Transit Center, San Diego (USA) arriving at 12/21/2025 2:10:00 PM. 50 Economy ticket for $349 per person are available. Travel duration is 53h 45m
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Greyhound US73h 0m08:10 PMIndianapolisCentral Bus Station6:10 PMSan DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/19/2025 8:10:00 PM to Old Town Transit Center, San Diego (USA) arriving at 12/22/2025 6:10:00 PM. 50 Economy ticket for $372 per person are available. Travel duration is 73h 0m
Cheapest Buses Friday
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Frontier Airlines25h 37m08:38 PMIndianapolis AirportIndianapolis Airport7:15 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/20/2025 8:38:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/21/2025 7:15:00 PM. 50 Economy ticket for $167 per person are available. Travel duration is 25h 37m
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Frontier Airlines6h 21m08:38 PMIndianapolis AirportIndianapolis Airport11:59 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/20/2025 8:38:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/20/2025 11:59:00 PM. 50 Economy ticket for $220 per person are available. Travel duration is 6h 21m
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United Airlines7h 56m01:45 PMIndianapolis AirportIndianapolis Airport6:41 PMSan Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/20/2025 1:45:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/20/2025 6:41:00 PM. 50 Economy ticket for $224 per person are available. Travel duration is 7h 56m
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United Airlines8h 22m03:25 PMIndianapolis AirportIndianapolis Airport8:47 PMSan Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/20/2025 3:25:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/20/2025 8:47:00 PM. 50 Economy ticket for $224 per person are available. Travel duration is 8h 22m
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American Airlines7h 20m05:29 AMIndianapolis AirportIndianapolis Airport9:49 AMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/20/2025 5:29:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/20/2025 9:49:00 AM. 50 Economy ticket for $472 per person are available. Travel duration is 7h 20m
Cheapest Flights Saturday
What are the fastest trips from Indianapolis to San Diego?
You can get to San Diego from Indianapolis in just 6h 11m with a Flight from Frontier Airlines. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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Frontier Airlines6h 11m08:48 PMIndianapolis AirportIndianapolis Airport11:59 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/14/2025 8:48:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/14/2025 11:59:00 PM. 50 Economy ticket for $273 per person are available. Travel duration is 6h 11m
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American Airlines7h 31m07:22 PMIndianapolis AirportIndianapolis Airport11:53 PMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/14/2025 7:22:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/14/2025 11:53:00 PM. 50 Economy ticket for $321 per person are available. Travel duration is 7h 31m
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Alaska Airlines7h 37m06:45 AMIndianapolis AirportIndianapolis Airport11:22 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/14/2025 6:45:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/14/2025 11:22:00 AM. 50 Economy ticket for $321 per person are available. Travel duration is 7h 37m
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United Airlines8h 53m05:45 AMIndianapolis AirportIndianapolis Airport11:38 AMSan Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/14/2025 5:45:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/14/2025 11:38:00 AM. 50 Economy ticket for $229 per person are available. Travel duration is 8h 53m
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Spirit Airlines13h 2m08:48 AMIndianapolis AirportIndianapolis Airport6:50 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Spirit Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/14/2025 8:48:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/14/2025 6:50:00 PM. 50 Economy ticket for $452 per person are available. Travel duration is 13h 2m
Fastest Flights Sunday
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American Airlines7h 28m05:26 AMIndianapolis AirportIndianapolis Airport9:54 AMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/15/2025 5:26:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/15/2025 9:54:00 AM. 50 Economy ticket for $321 per person are available. Travel duration is 7h 28m
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United Airlines8h 53m05:45 AMIndianapolis AirportIndianapolis Airport11:38 AMSan Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/15/2025 5:45:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/15/2025 11:38:00 AM. 50 Economy ticket for $229 per person are available. Travel duration is 8h 53m
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Spirit Airlines13h 2m08:48 AMIndianapolis AirportIndianapolis Airport6:50 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Spirit Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/15/2025 8:48:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/15/2025 6:50:00 PM. 50 Economy ticket for $382 per person are available. Travel duration is 13h 2m
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Alaska Airlines17h 43m07:30 PMIndianapolis AirportIndianapolis Airport10:13 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/15/2025 7:30:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/16/2025 10:13:00 AM. 50 Economy ticket for $234 per person are available. Travel duration is 17h 43m
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Allegiant Air36h 53m08:00 AMIndianapolis AirportIndianapolis Airport5:53 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Allegiant Air goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/15/2025 8:00:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/16/2025 5:53:00 PM. 50 Economy ticket for $177 per person are available. Travel duration is 36h 53m
Fastest Flights Monday
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Greyhound US53h 15m011:25 AMIndianapolisCentral Bus Station1:40 PMSan DiegoLa Jolla Village0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/16/2025 11:25:00 AM to La Jolla Village, San Diego (USA) arriving at 12/18/2025 1:40:00 PM. 50 Economy ticket for $317 per person are available. Travel duration is 53h 15m
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Greyhound US53h 45m011:25 AMIndianapolisCentral Bus Station2:10 PMSan DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/16/2025 11:25:00 AM to Old Town Transit Center, San Diego (USA) arriving at 12/18/2025 2:10:00 PM. 50 Economy ticket for $316 per person are available. Travel duration is 53h 45m
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FlixBus56h 5m08:35 AMIndianapolisWashington / Delaware1:40 PMSan DiegoLa Jolla Village0EconomyA Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/16/2025 8:35:00 AM to La Jolla Village, San Diego (USA) arriving at 12/18/2025 1:40:00 PM. 50 Economy ticket for $315 per person are available. Travel duration is 56h 5m
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FlixBus56h 35m08:35 AMIndianapolisWashington / Delaware2:10 PMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/16/2025 8:35:00 AM to Old Town Transit Center, San Diego (USA) arriving at 12/18/2025 2:10:00 PM. 50 Economy ticket for $315 per person are available. Travel duration is 56h 35m
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FlixBus64h 40m08:35 AMIndianapolisWashington / Delaware10:15 PMSan DiegoSeaport Village0EconomyA Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/16/2025 8:35:00 AM to Seaport Village, San Diego (USA) arriving at 12/18/2025 10:15:00 PM. 50 Economy ticket for $316 per person are available. Travel duration is 64h 40m
Fastest Buses Tuesday
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United Airlines6h 44m06:00 AMIndianapolis AirportIndianapolis Airport9:44 AMSan Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/18/2025 6:00:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/18/2025 9:44:00 AM. 50 Economy ticket for $229 per person are available. Travel duration is 6h 44m
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Alaska Airlines7h 7m02:12 PMIndianapolis AirportIndianapolis Airport6:19 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/18/2025 2:12:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/18/2025 6:19:00 PM. 50 Economy ticket for $320 per person are available. Travel duration is 7h 7m
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American Airlines7h 20m05:29 AMIndianapolis AirportIndianapolis Airport9:49 AMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/18/2025 5:29:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/18/2025 9:49:00 AM. 50 Economy ticket for $320 per person are available. Travel duration is 7h 20m
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Alaska Airlines7h 32m06:55 AMIndianapolis AirportIndianapolis Airport11:27 AMSan Diego AirportSan Diego Airport0EconomyA Flight from Alaska Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/18/2025 6:55:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/18/2025 11:27:00 AM. 50 Economy ticket for $320 per person are available. Travel duration is 7h 32m
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United Airlines9h 0m05:45 AMIndianapolis AirportIndianapolis Airport11:45 AMSan Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/18/2025 5:45:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/18/2025 11:45:00 AM. 50 Economy ticket for $229 per person are available. Travel duration is 9h 0m
Fastest Flights Thursday
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Greyhound US53h 15m011:25 AMIndianapolisCentral Bus Station1:40 PMSan DiegoLa Jolla Village0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/19/2025 11:25:00 AM to La Jolla Village, San Diego (USA) arriving at 12/21/2025 1:40:00 PM. 50 Economy ticket for $346 per person are available. Travel duration is 53h 15m
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Greyhound US53h 45m011:25 AMIndianapolisCentral Bus Station2:10 PMSan DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/19/2025 11:25:00 AM to Old Town Transit Center, San Diego (USA) arriving at 12/21/2025 2:10:00 PM. 50 Economy ticket for $349 per person are available. Travel duration is 53h 45m
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FlixBus56h 5m08:35 AMIndianapolisWashington / Delaware1:40 PMSan DiegoLa Jolla Village0EconomyA Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/19/2025 8:35:00 AM to La Jolla Village, San Diego (USA) arriving at 12/21/2025 1:40:00 PM. 50 Economy ticket for $329 per person are available. Travel duration is 56h 5m
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FlixBus56h 35m08:35 AMIndianapolisWashington / Delaware2:10 PMSan DiegoOld Town Transit Center0EconomyA Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/19/2025 8:35:00 AM to Old Town Transit Center, San Diego (USA) arriving at 12/21/2025 2:10:00 PM. 50 Economy ticket for $329 per person are available. Travel duration is 56h 35m
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Greyhound US73h 0m08:10 PMIndianapolisCentral Bus Station6:10 PMSan DiegoOld Town Transit Center0EconomyA Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/19/2025 8:10:00 PM to Old Town Transit Center, San Diego (USA) arriving at 12/22/2025 6:10:00 PM. 50 Economy ticket for $372 per person are available. Travel duration is 73h 0m
Fastest Buses Friday
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Frontier Airlines6h 21m08:38 PMIndianapolis AirportIndianapolis Airport11:59 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/20/2025 8:38:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/20/2025 11:59:00 PM. 50 Economy ticket for $220 per person are available. Travel duration is 6h 21m
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American Airlines7h 20m05:29 AMIndianapolis AirportIndianapolis Airport9:49 AMSan Diego AirportSan Diego Airport0EconomyA Flight from American Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/20/2025 5:29:00 AM to San Diego Airport, San Diego Airport (USA) arriving at 12/20/2025 9:49:00 AM. 50 Economy ticket for $472 per person are available. Travel duration is 7h 20m
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United Airlines7h 56m01:45 PMIndianapolis AirportIndianapolis Airport6:41 PMSan Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/20/2025 1:45:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/20/2025 6:41:00 PM. 50 Economy ticket for $224 per person are available. Travel duration is 7h 56m
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United Airlines8h 22m03:25 PMIndianapolis AirportIndianapolis Airport8:47 PMSan Diego AirportSan Diego Airport0EconomyA Flight from United Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/20/2025 3:25:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/20/2025 8:47:00 PM. 50 Economy ticket for $224 per person are available. Travel duration is 8h 22m
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Frontier Airlines25h 37m08:38 PMIndianapolis AirportIndianapolis Airport7:15 PMSan Diego AirportSan Diego Airport0EconomyA Flight from Frontier Airlines goes from Indianapolis Airport, Indianapolis Airport (USA) at 12/20/2025 8:38:00 PM to San Diego Airport, San Diego Airport (USA) arriving at 12/21/2025 7:15:00 PM. 50 Economy ticket for $167 per person are available. Travel duration is 25h 37m
Fastest Flights Saturday
Here you will find all operators and timetables for a
Bus from Indianapolis to San Diego
What are the most popular stations in Indianapolis and San Diego?
In Indianapolis, you will usually depart from Central Bus Station, Greyhound Bus Station or Downtown Transit Center, while in San Diego you will be arriving at San Ysidro Transit Center, University Av & Bancroft St Bus Stop or Old Town Transit Center, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to San Diego from Indianapolis? With 5 connections between 2 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Indianapolis and San Diego, you can pay as low as $167 with a Flight from Frontier Airlines.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from Frontier Airlines: you will get to San Diego in just 6h 11m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Indianapolis and San Diego are United Airlines, FlixBus and Greyhound US, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Indianapolis and San Diego is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Beech Grove, IN or to San Diego Airport, and look at flights from Indianapolis Airport, and landing at Tijuana Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Indianapolis to San Diego?
The most popular companies between Indianapolis and San Diego, are United Airlines, FlixBus and Greyhound US. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus and Greyhound US
Airlines: United Airlines, Alaska Airlines, American Airlines and 3 more.
All you need to know when you travel from Indianapolis to San Diego
Check all information on comfort and services on all modes of transports from Indianapolis to San Diego. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Indianapolis to San Diego
How can I reach San Diego from Indianapolis?
Every day, there are on average 5 connections between Bus and Flight, with which you can get to San Diego from Indianapolis.
How far is San Diego from Indianapolis?
The distance between Indianapolis and San Diego is 1,785.2 miles.
What is the most ecofriendly mode of transport between Indianapolis and San Diego?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 78 kgs of CO2, a train 101 kgs, a car 488 kgs, and a flight 707 kgs.
What is the cheapest mode of transport from Indianapolis to San Diego?
You can get to San Diego with just $167 by taking a Flight from Frontier Airlines.
What is the fastest way to get from Indianapolis to San Diego?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to San Diego in just 6h 11m with a Flight from Frontier Airlines.
More routes to Indianapolis and to San Diego
Looking for more options? Here you can see the most popular routes to Indianapolis and to San Diego. Simply click on a connection, and you’ll find all the details about the route!

