Bus Indianapolis to San Diego - Compare all Companies

Compare all timetables for the bus from Indianapolis to San Diego

Here is a selection of the cheapest bus trips from the schedule from Indianapolis to San Diego from various bus operators like FlixBus or Greyhound US for the next days.

today

$224

tomorrow

$171

Sunday

Monday

$289

Tuesday

Wednesday

$189

Thursday

$322

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	61h 35m	11:30 PM	Indianapolis	Washington / Delaware	10:05 AM	San Diego	Seaport Village	Economy	$224	A Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/5/2025 11:30:00 PM to Seaport Village, San Diego (USA) arriving at 12/8/2025 10:05:00 AM. 50 Economy ticket for $224 per person are available. Travel duration is 61h 35m
Greyhound US	64h 55m	8:10 PM	Indianapolis	Central Bus Station	10:05 AM	San Diego	Seaport Village	Economy	$224	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/5/2025 8:10:00 PM to Seaport Village, San Diego (USA) arriving at 12/8/2025 10:05:00 AM. 50 Economy ticket for $224 per person are available. Travel duration is 64h 55m
FlixBus	65h 40m	11:30 PM	Indianapolis	Washington / Delaware	2:10 PM	San Diego	Old Town Transit Center	Economy	$226	A Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/5/2025 11:30:00 PM to Old Town Transit Center, San Diego (USA) arriving at 12/8/2025 2:10:00 PM. 50 Economy ticket for $226 per person are available. Travel duration is 65h 40m
FlixBus	61h 10m	11:30 PM	Indianapolis	Washington / Delaware	9:40 AM	San Diego	La Jolla Village	Economy	$226	A Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/5/2025 11:30:00 PM to La Jolla Village, San Diego (USA) arriving at 12/8/2025 9:40:00 AM. 50 Economy ticket for $226 per person are available. Travel duration is 61h 10m
Greyhound US	54h 15m	11:25 AM	Indianapolis	Central Bus Station	2:40 PM	San Diego	San Ysidro Transit Center	Economy	$239	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/5/2025 11:25:00 AM to San Ysidro Transit Center, San Diego (USA) arriving at 12/7/2025 2:40:00 PM. 50 Economy ticket for $239 per person are available. Travel duration is 54h 15m

Did you know that if you travel from Indianapolis to San Diego via St. Louis, MO, you can save more than $36? You can find the corresponding connections below.
- Busbud
  
  57h 20m
  
  0
  
  11:25 AM
  
  Indianapolis
  Central Bus Station
  
  3:20 PM
  
  St. Louis, MO
  Gateway Station
  
  0
  
  Economy
  
  $35
  
  A Bus from Busbud goes from Central Bus Station, Indianapolis (USA) at 12/6/2025 11:25:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/6/2025 3:20:00 PM. 50 Economy ticket for $35 per person are available. Travel duration is 4h 55m
- FlixBus
  
  51h 45m
  
  0
  
  4:00 PM
  
  St. Louis, MO
  Gateway Station
  
  5:45 PM
  
  San Diego
  Old Town Transit Center
  
  0
  
  Economy
  
  $153
  
  A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/6/2025 4:00:00 PM to Old Town Transit Center, San Diego (USA) arriving at 12/8/2025 5:45:00 PM. 50 Economy ticket for $153 per person are available. Travel duration is 51h 45m
Travel time is 6h 5m longer, but you will save $36

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	53h 15m	11:25 AM	Indianapolis	Central Bus Station	1:40 PM	San Diego	La Jolla Village	Economy	$171	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/6/2025 11:25:00 AM to La Jolla Village, San Diego (USA) arriving at 12/8/2025 1:40:00 PM. 50 Economy ticket for $171 per person are available. Travel duration is 53h 15m
Greyhound US	53h 45m	11:25 AM	Indianapolis	Central Bus Station	2:10 PM	San Diego	Old Town Transit Center	Economy	$173	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/6/2025 11:25:00 AM to Old Town Transit Center, San Diego (USA) arriving at 12/8/2025 2:10:00 PM. 50 Economy ticket for $173 per person are available. Travel duration is 53h 45m
FlixBus	63h 15m	11:30 PM	Indianapolis	Washington / Delaware	11:45 AM	San Diego	Old Town Transit Center	Economy	$176	A Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/6/2025 11:30:00 PM to Old Town Transit Center, San Diego (USA) arriving at 12/9/2025 11:45:00 AM. 50 Economy ticket for $176 per person are available. Travel duration is 63h 15m
FlixBus	69h 40m	11:30 PM	Indianapolis	Washington / Delaware	6:10 PM	San Diego	Old Town Transit Center	Economy	$179	A Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/6/2025 11:30:00 PM to Old Town Transit Center, San Diego (USA) arriving at 12/9/2025 6:10:00 PM. 50 Economy ticket for $179 per person are available. Travel duration is 69h 40m
FlixBus	69h 5m	11:30 PM	Indianapolis	Washington / Delaware	5:35 PM	San Diego	La Jolla Village	Economy	$179	A Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/6/2025 11:30:00 PM to La Jolla Village, San Diego (USA) arriving at 12/9/2025 5:35:00 PM. 50 Economy ticket for $179 per person are available. Travel duration is 69h 5m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	63h 50m	11:30 PM	Indianapolis	Washington / Delaware	12:20 PM	San Diego	San Ysidro Transit Center	Economy	$289	A Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/8/2025 11:30:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 12/11/2025 12:20:00 PM. 50 Economy ticket for $289 per person are available. Travel duration is 63h 50m
FlixBus	60h 15m	9:30 AM	Indianapolis	Washington / Delaware	6:45 PM	San Diego	San Ysidro Transit Center	Economy	$292	A Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/8/2025 9:30:00 AM to San Ysidro Transit Center, San Diego (USA) arriving at 12/10/2025 6:45:00 PM. 50 Economy ticket for $292 per person are available. Travel duration is 60h 15m
Greyhound US	49h 40m	8:05 PM	Indianapolis	Central Bus Station	6:45 PM	San Diego	San Ysidro Transit Center	Economy	$292	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/8/2025 8:05:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 12/10/2025 6:45:00 PM. 50 Economy ticket for $292 per person are available. Travel duration is 49h 40m

Did you know that if you travel from Indianapolis to San Diego via St. Louis, MO, you can save more than $101? You can find the corresponding connections below.
- Busbud
  
  57h 20m
  
  0
  
  11:25 AM
  
  Indianapolis
  Central Bus Station
  
  3:20 PM
  
  St. Louis, MO
  Gateway Station
  
  0
  
  Economy
  
  $35
  
  A Bus from Busbud goes from Central Bus Station, Indianapolis (USA) at 12/6/2025 11:25:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/6/2025 3:20:00 PM. 50 Economy ticket for $35 per person are available. Travel duration is 4h 55m
- FlixBus
  
  51h 45m
  
  0
  
  4:00 PM
  
  St. Louis, MO
  Gateway Station
  
  5:45 PM
  
  San Diego
  Old Town Transit Center
  
  0
  
  Economy
  
  $153
  
  A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/6/2025 4:00:00 PM to Old Town Transit Center, San Diego (USA) arriving at 12/8/2025 5:45:00 PM. 50 Economy ticket for $153 per person are available. Travel duration is 51h 45m
Travel time is 10h 40m longer, but you will save $101

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	64h 40m	8:35 AM	Indianapolis	Washington / Delaware	10:15 PM	San Diego	Seaport Village	Economy	$189	A Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/10/2025 8:35:00 AM to Seaport Village, San Diego (USA) arriving at 12/12/2025 10:15:00 PM. 50 Economy ticket for $189 per person are available. Travel duration is 64h 40m
FlixBus	56h 35m	8:35 AM	Indianapolis	Washington / Delaware	2:10 PM	San Diego	Old Town Transit Center	Economy	$189	A Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/10/2025 8:35:00 AM to Old Town Transit Center, San Diego (USA) arriving at 12/12/2025 2:10:00 PM. 50 Economy ticket for $189 per person are available. Travel duration is 56h 35m
FlixBus	66h 15m	8:35 AM	Indianapolis	Washington / Delaware	11:50 PM	San Diego	Old Town Transit Center	Economy	$189	A Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/10/2025 8:35:00 AM to Old Town Transit Center, San Diego (USA) arriving at 12/12/2025 11:50:00 PM. 50 Economy ticket for $189 per person are available. Travel duration is 66h 15m
Greyhound US	53h 45m	11:25 AM	Indianapolis	Central Bus Station	2:10 PM	San Diego	Old Town Transit Center	Economy	$190	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/10/2025 11:25:00 AM to Old Town Transit Center, San Diego (USA) arriving at 12/12/2025 2:10:00 PM. 50 Economy ticket for $190 per person are available. Travel duration is 53h 45m
Greyhound US	53h 15m	11:25 AM	Indianapolis	Central Bus Station	1:40 PM	San Diego	La Jolla Village	Economy	$192	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/10/2025 11:25:00 AM to La Jolla Village, San Diego (USA) arriving at 12/12/2025 1:40:00 PM. 50 Economy ticket for $192 per person are available. Travel duration is 53h 15m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	56h 35m	8:35 AM	Indianapolis	Washington / Delaware	2:10 PM	San Diego	Old Town Transit Center	Economy	$322	A Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/11/2025 8:35:00 AM to Old Town Transit Center, San Diego (USA) arriving at 12/13/2025 2:10:00 PM. 50 Economy ticket for $322 per person are available. Travel duration is 56h 35m
FlixBus	59h 40m	9:30 AM	Indianapolis	Washington / Delaware	6:10 PM	San Diego	Old Town Transit Center	Economy	$322	A Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/11/2025 9:30:00 AM to Old Town Transit Center, San Diego (USA) arriving at 12/13/2025 6:10:00 PM. 50 Economy ticket for $322 per person are available. Travel duration is 59h 40m
FlixBus	56h 5m	8:35 AM	Indianapolis	Washington / Delaware	1:40 PM	San Diego	La Jolla Village	Economy	$322	A Bus from FlixBus goes from Washington / Delaware, Indianapolis (USA) at 12/11/2025 8:35:00 AM to La Jolla Village, San Diego (USA) arriving at 12/13/2025 1:40:00 PM. 50 Economy ticket for $322 per person are available. Travel duration is 56h 5m
Greyhound US	53h 45m	11:25 AM	Indianapolis	Central Bus Station	2:10 PM	San Diego	Old Town Transit Center	Economy	$323	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/11/2025 11:25:00 AM to Old Town Transit Center, San Diego (USA) arriving at 12/13/2025 2:10:00 PM. 50 Economy ticket for $323 per person are available. Travel duration is 53h 45m
Greyhound US	53h 15m	11:25 AM	Indianapolis	Central Bus Station	1:40 PM	San Diego	La Jolla Village	Economy	$324	A Bus from Greyhound US goes from Central Bus Station, Indianapolis (USA) at 12/11/2025 11:25:00 AM to La Jolla Village, San Diego (USA) arriving at 12/13/2025 1:40:00 PM. 50 Economy ticket for $324 per person are available. Travel duration is 53h 15m

Did you know that if you travel from Indianapolis to San Diego via St. Louis, MO, you can save more than $134? You can find the corresponding connections below.
- Busbud
  
  57h 20m
  
  0
  
  11:25 AM
  
  Indianapolis
  Central Bus Station
  
  3:20 PM
  
  St. Louis, MO
  Gateway Station
  
  0
  
  Economy
  
  $35
  
  A Bus from Busbud goes from Central Bus Station, Indianapolis (USA) at 12/6/2025 11:25:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/6/2025 3:20:00 PM. 50 Economy ticket for $35 per person are available. Travel duration is 4h 55m
- FlixBus
  
  51h 45m
  
  0
  
  4:00 PM
  
  St. Louis, MO
  Gateway Station
  
  5:45 PM
  
  San Diego
  Old Town Transit Center
  
  0
  
  Economy
  
  $153
  
  A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/6/2025 4:00:00 PM to Old Town Transit Center, San Diego (USA) arriving at 12/8/2025 5:45:00 PM. 50 Economy ticket for $153 per person are available. Travel duration is 51h 45m
Travel time is 7h 5m longer, but you will save $134

Best Price Offer: The price for the cheapest bus from Indianapolis to San Diego is $171 on 12/6/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between Indianapolis and San Diego

See here how frequent the connections between Indianapolis and San Diego are, during different times and days of the week.

Friday is the busiest day, with more than 23 daily buses from Indianapolis to San Diego. Monday has instead the fewest connections, with only 3 daily coaches between Indianapolis and San Diego.

The busiest time of the day is the Evening, with 46 buses from Indianapolis to San Diego, while Morning sees the fewest connections between Indianapolis and San Diego, with 39 offers.

Facts about the bus from Indianapolis to San Diego

Compare all providers like FlixBus and Greyhound US that travel 17 times every day by bus from Indianapolis to San Diego in one click! Book your bus ticket from Indianapolis to San Diego starting from $171!

Cheapest Bus	$171
Fastest Bus	45h 30m
Earliest Bus	8:35 AM
Latest Bus	11:30 PM
Daily Bus Routes	17 Ø
Distance	1,785.2 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from Indianapolis to San Diego

Every day, 17 buses from 2 bus companies leave Indianapolis for San Diego: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/05/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 11/30

Monday 12/01

Tuesday 12/02

Wednesday 12/03

Thursday 12/04

Friday 12/05

$239

Saturday 12/06

$171

Sunday 12/07

Monday 12/08

$289

Tuesday 12/09

Wednesday 12/10

$189

Thursday 12/11

$322

Friday 12/12

Saturday 12/13

$315

Sunday 12/14

Monday 12/15

Tuesday 12/16

Wednesday 12/17

Thursday 12/18

Friday 12/19

Saturday 12/20

Sunday 12/21

Monday 12/22

Tuesday 12/23

Wednesday 12/24

Thursday 12/25

Friday 12/26

Saturday 12/27

The cheapest time to travel from Indianapolis to San Diego

See here on which day and which time of the day you can find the cheapest bus ticket from Indianapolis to San Diego, for the next 30 days.

With a price starting from $171, Saturday is the cheapest day for a bus from Indianapolis to San Diego. Thursday instead is the most expensive day with prices starting from $322.

Morning is the cheapest day time for bus tickets from Indianapolis to San Diego, with $171. Evening is the most expensive time of the day with prices starting from $176.

How to save money travelling from Indianapolis to San Diego

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Indianapolis to San Diego in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Indianapolis to San Diego, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Indianapolis to San Diego are also emptier.

All bus stations and stops in Indianapolis and San Diego

In the map below, you can see where to find all bus stations in Indianapolis and San Diego.

Mile Square

Monument Circle 2250

Washington / Delaware

E Washington St between N Delaware St and N Alabama St

Central Bus Station

Greyhound Bus Station

S Illinois St 350

S Keystone Avenue

S Keystone Avenue 3649

Old Town Transit Center

Congress Street 2727

San Ysidro Transit Center

E San Ysidro Blvd 723

Santa Fe Depot

Kettner Blvd 1050

Seaport Village

W Harbor Dr 789

La Jolla Village

Hyatt Regency

Service and Comfort on the bus from Indianapolis to San Diego

Want to know which seat classes are available on the buses from Indianapolis to San Diego? Or which bus companies serve the route Indianapolis to San Diego? Below you will find answers to your questions.

FAQs about the Indianapolis to San Diego bus

How much does a Indianapolis San Diego bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $171 and takes 50h 15m to reach San Diego. Compare offers to save money!

How much could I save by comparing buses from Indianapolis to San Diego?

This route is offered by 2 companies with a range of ticket prices between $171 and $339. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to San Diego.

On average, how many connections are available from Indianapolis to San Diego each day?

Every day, the Indianapolis to San Diego bus route is served by approximately 17 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Indianapolis to San Diego take?

The fastest bus from Indianapolis to San Diego is offered by Greyhound US and takes 45h 30m. Bus tickets for this connection cost $245. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Indianapolis to San Diego?

The earliest bus arriving in San Diego from Indianapolis starts at 8:35 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Indianapolis to San Diego?

The latest bus trip departing from Indianapolis for San Diego starts at 11:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Indianapolis San Diego route?

When traveling by bus from Indianapolis to San Diego, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Indianapolis and San Diego?

You can check all the direct connections between Indianapolis and San Diego by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the Indianapolis to San Diego bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Indianapolis San Diego bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Indianapolis San Diego bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Indianapolis to San Diego on your planned travel date.

Available seat classes which are offered on the bus route Indianapolis to San Diego

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Indianapolis and to San Diego

Here’s an overview of the most popular bus routes to Indianapolis and to San Diego. Simply click on the connection of your choice, and you will find all the details about your bus route!