Bus from Knoxville, TN to Indianapolis from $63

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Compare all timetables for the bus from Knoxville, TN to Indianapolis

Here is a selection of the cheapest bus trips from the schedule from Knoxville, TN to Indianapolis from various bus operators like Greyhound US for the next days.

today
tomorrow
$88
Thursday
Friday
$74
Saturday
$79
Sunday
Monday

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 10h 35m 6:10 PM Knoxville, TN Greyhound Bus Station 4:45 AM Indianapolis Central Bus Station  Economy $88
Greyhound US 14h 15m 6:10 PM Knoxville, TN Greyhound Bus Station 8:25 AM Indianapolis Washington / Delaware  Economy $89
Greyhound US 16h 25m 7:40 PM Knoxville, TN Greyhound Bus Station 12:05 PM Indianapolis Central Bus Station  Economy $89
  • Did you know that if you travel from Knoxville, TN to Indianapolis via Nashville, you can save more than $15? You can find the corresponding connections below.
    • Greyhound US
      10h 35m
      0
      6:10 PM
      Knoxville, TN
      Greyhound Bus Station
      7:55 PM
      Nashville
      5th Ave South Station
      0
      Greyhound US
      Economy
      $38
      • Waiting Time 2h 20m
    • Greyhound US
      5h 30m
      0
      10:15 PM
      Nashville
      5th Ave South Station
      4:45 AM
      Indianapolis
      Central Bus Station
      0
      Greyhound US
      Economy
      $35
    Travel time is the same as the direct connection, but you will save $15

Cheapest bus trips Friday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 14h 15m 6:10 PM Knoxville, TN Greyhound Bus Station 8:25 AM Indianapolis Washington / Delaware  Economy $74
Greyhound US 10h 35m 6:10 PM Knoxville, TN Greyhound Bus Station 4:45 AM Indianapolis Central Bus Station  Economy $75
Greyhound US 16h 25m 7:40 PM Knoxville, TN Greyhound Bus Station 12:05 PM Indianapolis Central Bus Station  Economy $78

Cheapest bus trips Saturday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 10h 35m 6:10 PM Knoxville, TN Knoxville Area Transit Bus Stop 4:45 AM Indianapolis Central Bus Station  Economy $79
Greyhound US 14h 15m 6:10 PM Knoxville, TN Knoxville Area Transit Bus Stop 8:25 AM Indianapolis Downtown Transit Center  Economy $80
Greyhound US 16h 25m 7:40 PM Knoxville, TN Knoxville Area Transit Bus Stop 12:05 PM Indianapolis Central Bus Station  Economy $80

Best Price Offer: The price for the cheapest bus from Knoxville, TN to Indianapolis is $63 on 4/2/2026. Flexible travelers save on ticket prices.


Facts about the bus from Knoxville, TN to Indianapolis

Compare all providers like Greyhound US that travel 3 times every day by bus from Knoxville, TN to Indianapolis in one click! Book your bus ticket from Knoxville, TN to Indianapolis starting from $63!

Cheapest Bus $63
Fastest Bus 10h 35m
Earliest Bus 6:10 PM
Latest Bus 7:40 PM
Daily Bus Routes 3 Ø
Distance 289.8 miles
Bus Companies Greyhound US

Cheapest bus connections from Knoxville, TN to Indianapolis

Every day, 3 buses from 1 bus companies leave Knoxville, TN for Indianapolis: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 03/24/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 03/22
Monday 03/23
Tuesday 03/24
Wednesday 03/25
$88
Thursday 03/26
Friday 03/27
$74
Saturday 03/28
$79
Sunday 03/29
Monday 03/30
Tuesday 03/31
Wednesday 04/01
Thursday 04/02
$63
Friday 04/03
Saturday 04/04
$71
Sunday 04/05
$72
Monday 04/06
$83
Tuesday 04/07
$86
Wednesday 04/08
$84
Thursday 04/09
$82
Friday 04/10
$75
Saturday 04/11
$73
Sunday 04/12
$76
Monday 04/13
$76
Tuesday 04/14
Wednesday 04/15
$82
Thursday 04/16
$74
Friday 04/17
$68
Saturday 04/18

How to save money travelling from Knoxville, TN to Indianapolis

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Knoxville, TN to Indianapolis in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Knoxville, TN to Indianapolis, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Knoxville, TN to Indianapolis are also emptier.

Beloved bus companies from Knoxville, TN to Indianapolis

These are the most booked bus companies between Knoxville, TN to Indianapolis from our users.

Greyhound US from Knoxville, TN to Indianapolis

Greyhound US

Here you will find the key facts about the Greyhound US bus route Knoxville, TN to Indianapolis:

Cheapest Price $74
Fastest Bus 10h 35m
Earliest Bus 6:10 PM
Last Bus 7:40 PM
Daily Connections 3 Ø
Found on 2/25/2026

All bus stations and stops in Knoxville, TN and Indianapolis

In the map below, you can see where to find all bus stations in Knoxville, TN and Indianapolis.

Service and Comfort on the bus from Knoxville, TN to Indianapolis

Want to know which seat classes are available on the buses from Knoxville, TN to Indianapolis? Or which bus companies serve the route Knoxville, TN to Indianapolis? Below you will find answers to your questions.

FAQs about the Knoxville, TN to Indianapolis bus

How much does a Knoxville, TN Indianapolis bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $63 and takes 14h 15m to reach Indianapolis. Compare offers to save money!

How much could I save by comparing buses from Knoxville, TN to Indianapolis?

This route is offered by 1 companies with a range of ticket prices between $63 and $89. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Indianapolis.

On average, how many connections are available from Knoxville, TN to Indianapolis each day?

Every day, the Knoxville, TN to Indianapolis bus route is served by approximately 3 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Knoxville, TN to Indianapolis take?

The fastest bus from Knoxville, TN to Indianapolis is offered by Greyhound US and takes 10h 35m. Bus tickets for this connection cost $88. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Knoxville, TN to Indianapolis?

The earliest bus arriving in Indianapolis from Knoxville, TN starts at 6:10 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Knoxville, TN to Indianapolis?

The latest bus trip departing from Knoxville, TN for Indianapolis starts at 7:40 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Knoxville, TN Indianapolis route?

When traveling by bus from Knoxville, TN to Indianapolis, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Knoxville, TN and Indianapolis?

You can check all the direct connections between Knoxville, TN and Indianapolis by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Knoxville, TN to Indianapolis bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Knoxville, TN Indianapolis bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Knoxville, TN Indianapolis bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Knoxville, TN to Indianapolis on your planned travel date.

How does CheckMyBus find the best bus deals from Knoxville, TN to Indianapolis?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 3 daily trips between Knoxville, TN and Indianapolis. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Knoxville, TN to Indianapolis?

Prices and availability for 3 trips between Knoxville, TN and Indianapolis change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Knoxville, TN to Indianapolis

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Knoxville, TN and to Indianapolis

Here’s an overview of the most popular bus routes to Knoxville, TN and to Indianapolis. Simply click on the connection of your choice, and you will find all the details about your bus route!
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Popular Airport Shuttles to Knoxville, TN and to Indianapolis
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