What is the best way to travel from St. Louis, MO to Detroit?
Looking for a trip? Compare all the available Flights and Buses for the journey to Detroit from St. Louis, MO. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
What is the cheapest way to reach Detroit from St. Louis, MO?
You can get to Detroit with just $60 by taking a Bus from Greyhound US, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
-
FlixBus13h 50m04:00 PMSt. Louis, MOGateway Station6:50 AMDetroitCentral Bus Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 3/16/2026 4:00:00 PM to Central Bus Station, Detroit (USA) arriving at 3/17/2026 6:50:00 AM. 50 Economy ticket for $64 per person are available. Travel duration is 13h 50m
-
FlixBus15h 10m011:30 PMSt. Louis, MOGateway Station3:40 PMDetroitCentral Bus Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 3/16/2026 11:30:00 PM to Central Bus Station, Detroit (USA) arriving at 3/17/2026 3:40:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 15h 10m
-
Greyhound US13h 10m08:45 AMSt. Louis, MOGateway Station10:55 PMDetroitCentral Bus Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 3/16/2026 8:45:00 AM to Central Bus Station, Detroit (USA) arriving at 3/16/2026 10:55:00 PM. 50 Economy ticket for $65 per person are available. Travel duration is 13h 10m
Cheapest Buses Monday
-
FlixBus15h 10m011:30 PMSt. Louis, MOGateway Station3:40 PMDetroitCentral Bus Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 3/17/2026 11:30:00 PM to Central Bus Station, Detroit (USA) arriving at 3/18/2026 3:40:00 PM. 50 Economy ticket for $82 per person are available. Travel duration is 15h 10m
-
Greyhound US13h 10m08:45 AMSt. Louis, MOGateway Station10:55 PMDetroitCentral Bus Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 3/17/2026 8:45:00 AM to Central Bus Station, Detroit (USA) arriving at 3/17/2026 10:55:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 13h 10m
-
FlixBus13h 50m04:00 PMSt. Louis, MOGateway Station6:50 AMDetroitCentral Bus Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 3/17/2026 4:00:00 PM to Central Bus Station, Detroit (USA) arriving at 3/18/2026 6:50:00 AM. 50 Economy ticket for $84 per person are available. Travel duration is 13h 50m
-
Frontier Airlines14h 6m08:06 PMSt. Louis Lambert AirportSt. Louis Lambert Airport11:12 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport0EconomyA Flight from Frontier Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 3/17/2026 8:06:00 PM to Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) arriving at 3/18/2026 11:12:00 AM. 50 Economy ticket for $241 per person are available. Travel duration is 14h 6m
-
Frontier Airlines16h 16m04:51 PMSt. Louis Lambert AirportSt. Louis Lambert Airport10:07 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport0EconomyA Flight from Frontier Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 3/17/2026 4:51:00 PM to Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) arriving at 3/18/2026 10:07:00 AM. 50 Economy ticket for $250 per person are available. Travel duration is 16h 16m
-
United Airlines8h 8m07:00 AMSt. Louis Lambert AirportSt. Louis Lambert Airport4:08 PMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport0EconomyA Flight from United Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 3/17/2026 7:00:00 AM to Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) arriving at 3/17/2026 4:08:00 PM. 50 Economy ticket for $456 per person are available. Travel duration is 8h 8m
-
United Airlines4h 31m07:40 AMSt. Louis Lambert AirportSt. Louis Lambert Airport1:11 PMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport0EconomyA Flight from United Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 3/17/2026 7:40:00 AM to Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) arriving at 3/17/2026 1:11:00 PM. 50 Economy ticket for $456 per person are available. Travel duration is 4h 31m
-
Skyscanner8h 8m07:00 AMSt. Louis Lambert AirportSt. Louis Lambert Airport4:08 PMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport0EconomyA Flight from Skyscanner goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 3/17/2026 7:00:00 AM to Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) arriving at 3/17/2026 4:08:00 PM. 50 Economy ticket for $683 per person are available. Travel duration is 8h 8m
-
Frontier Airlines36h 33m06:00 AMSt. Louis Lambert AirportSt. Louis Lambert Airport7:33 PMWindsor International AirportWindsor International Airport0EconomyA Flight from Frontier Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 3/17/2026 6:00:00 AM to Windsor International Airport, Windsor International Airport (Canada) arriving at 3/18/2026 7:33:00 PM. 50 Economy ticket for $964 per person are available. Travel duration is 36h 33m
Cheapest Buses Tuesday
Cheapest Flights Tuesday
-
Greyhound US13h 10m08:45 AMSt. Louis, MOGateway Station10:55 PMDetroitCentral Bus Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 3/19/2026 8:45:00 AM to Central Bus Station, Detroit (USA) arriving at 3/19/2026 10:55:00 PM. 50 Economy ticket for $60 per person are available. Travel duration is 13h 10m
-
FlixBus14h 15m011:30 PMSt. Louis, MOGateway Station2:45 PMDetroitCentral Bus Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 3/19/2026 11:30:00 PM to Central Bus Station, Detroit (USA) arriving at 3/20/2026 2:45:00 PM. 50 Economy ticket for $60 per person are available. Travel duration is 14h 15m
-
Greyhound US19h 0m01:55 PMSt. Louis, MOGateway Station9:55 AMDetroitCentral Bus Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 3/19/2026 1:55:00 PM to Central Bus Station, Detroit (USA) arriving at 3/20/2026 9:55:00 AM. 50 Economy ticket for $62 per person are available. Travel duration is 19h 0m
Cheapest Buses Thursday
-
FlixBus14h 15m011:30 PMSt. Louis, MOGateway Station2:45 PMDetroitCentral Bus Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 3/21/2026 11:30:00 PM to Central Bus Station, Detroit (USA) arriving at 3/22/2026 2:45:00 PM. 50 Economy ticket for $70 per person are available. Travel duration is 14h 15m
-
Greyhound US13h 10m08:45 AMSt. Louis, MOGateway Station10:55 PMDetroitCentral Bus Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 3/21/2026 8:45:00 AM to Central Bus Station, Detroit (USA) arriving at 3/21/2026 10:55:00 PM. 50 Economy ticket for $72 per person are available. Travel duration is 13h 10m
-
FlixBus13h 50m04:00 PMSt. Louis, MOGateway Station6:50 AMDetroitCentral Bus Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 3/21/2026 4:00:00 PM to Central Bus Station, Detroit (USA) arriving at 3/22/2026 6:50:00 AM. 50 Economy ticket for $74 per person are available. Travel duration is 13h 50m
Cheapest Buses Saturday
What are the fastest trips from St. Louis, MO to Detroit?
You can get to Detroit from St. Louis, MO in just 4h 31m with a Flight from United Airlines. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
-
Greyhound US13h 10m08:45 AMSt. Louis, MOGateway Station10:55 PMDetroitCentral Bus Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 3/16/2026 8:45:00 AM to Central Bus Station, Detroit (USA) arriving at 3/16/2026 10:55:00 PM. 50 Economy ticket for $65 per person are available. Travel duration is 13h 10m
-
FlixBus13h 50m04:00 PMSt. Louis, MOGateway Station6:50 AMDetroitCentral Bus Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 3/16/2026 4:00:00 PM to Central Bus Station, Detroit (USA) arriving at 3/17/2026 6:50:00 AM. 50 Economy ticket for $64 per person are available. Travel duration is 13h 50m
-
FlixBus15h 10m011:30 PMSt. Louis, MOGateway Station3:40 PMDetroitCentral Bus Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 3/16/2026 11:30:00 PM to Central Bus Station, Detroit (USA) arriving at 3/17/2026 3:40:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 15h 10m
Fastest Buses Monday
-
United Airlines4h 31m07:40 AMSt. Louis Lambert AirportSt. Louis Lambert Airport1:11 PMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport0EconomyA Flight from United Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 3/17/2026 7:40:00 AM to Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) arriving at 3/17/2026 1:11:00 PM. 50 Economy ticket for $456 per person are available. Travel duration is 4h 31m
-
United Airlines8h 8m07:00 AMSt. Louis Lambert AirportSt. Louis Lambert Airport4:08 PMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport0EconomyA Flight from United Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 3/17/2026 7:00:00 AM to Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) arriving at 3/17/2026 4:08:00 PM. 50 Economy ticket for $456 per person are available. Travel duration is 8h 8m
-
Skyscanner8h 8m07:00 AMSt. Louis Lambert AirportSt. Louis Lambert Airport4:08 PMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport0EconomyA Flight from Skyscanner goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 3/17/2026 7:00:00 AM to Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) arriving at 3/17/2026 4:08:00 PM. 50 Economy ticket for $683 per person are available. Travel duration is 8h 8m
-
Frontier Airlines14h 6m08:06 PMSt. Louis Lambert AirportSt. Louis Lambert Airport11:12 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport0EconomyA Flight from Frontier Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 3/17/2026 8:06:00 PM to Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) arriving at 3/18/2026 11:12:00 AM. 50 Economy ticket for $241 per person are available. Travel duration is 14h 6m
-
Frontier Airlines16h 16m04:51 PMSt. Louis Lambert AirportSt. Louis Lambert Airport10:07 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport0EconomyA Flight from Frontier Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 3/17/2026 4:51:00 PM to Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) arriving at 3/18/2026 10:07:00 AM. 50 Economy ticket for $250 per person are available. Travel duration is 16h 16m
-
Frontier Airlines36h 33m06:00 AMSt. Louis Lambert AirportSt. Louis Lambert Airport7:33 PMWindsor International AirportWindsor International Airport0EconomyA Flight from Frontier Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 3/17/2026 6:00:00 AM to Windsor International Airport, Windsor International Airport (Canada) arriving at 3/18/2026 7:33:00 PM. 50 Economy ticket for $964 per person are available. Travel duration is 36h 33m
-
Greyhound US13h 10m08:45 AMSt. Louis, MOGateway Station10:55 PMDetroitCentral Bus Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 3/17/2026 8:45:00 AM to Central Bus Station, Detroit (USA) arriving at 3/17/2026 10:55:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 13h 10m
-
FlixBus13h 50m04:00 PMSt. Louis, MOGateway Station6:50 AMDetroitCentral Bus Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 3/17/2026 4:00:00 PM to Central Bus Station, Detroit (USA) arriving at 3/18/2026 6:50:00 AM. 50 Economy ticket for $84 per person are available. Travel duration is 13h 50m
-
FlixBus15h 10m011:30 PMSt. Louis, MOGateway Station3:40 PMDetroitCentral Bus Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 3/17/2026 11:30:00 PM to Central Bus Station, Detroit (USA) arriving at 3/18/2026 3:40:00 PM. 50 Economy ticket for $82 per person are available. Travel duration is 15h 10m
Fastest Flights Tuesday
Fastest Buses Tuesday
-
Greyhound US13h 10m08:45 AMSt. Louis, MOGateway Station10:55 PMDetroitCentral Bus Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 3/19/2026 8:45:00 AM to Central Bus Station, Detroit (USA) arriving at 3/19/2026 10:55:00 PM. 50 Economy ticket for $60 per person are available. Travel duration is 13h 10m
-
FlixBus14h 15m011:30 PMSt. Louis, MOGateway Station2:45 PMDetroitCentral Bus Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 3/19/2026 11:30:00 PM to Central Bus Station, Detroit (USA) arriving at 3/20/2026 2:45:00 PM. 50 Economy ticket for $60 per person are available. Travel duration is 14h 15m
-
Greyhound US19h 0m01:55 PMSt. Louis, MOGateway Station9:55 AMDetroitCentral Bus Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 3/19/2026 1:55:00 PM to Central Bus Station, Detroit (USA) arriving at 3/20/2026 9:55:00 AM. 50 Economy ticket for $62 per person are available. Travel duration is 19h 0m
Fastest Buses Thursday
-
Greyhound US13h 10m08:45 AMSt. Louis, MOGateway Station10:55 PMDetroitCentral Bus Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 3/21/2026 8:45:00 AM to Central Bus Station, Detroit (USA) arriving at 3/21/2026 10:55:00 PM. 50 Economy ticket for $72 per person are available. Travel duration is 13h 10m
-
FlixBus13h 50m04:00 PMSt. Louis, MOGateway Station6:50 AMDetroitCentral Bus Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 3/21/2026 4:00:00 PM to Central Bus Station, Detroit (USA) arriving at 3/22/2026 6:50:00 AM. 50 Economy ticket for $74 per person are available. Travel duration is 13h 50m
-
FlixBus14h 15m011:30 PMSt. Louis, MOGateway Station2:45 PMDetroitCentral Bus Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 3/21/2026 11:30:00 PM to Central Bus Station, Detroit (USA) arriving at 3/22/2026 2:45:00 PM. 50 Economy ticket for $70 per person are available. Travel duration is 14h 15m
Fastest Buses Saturday
Here you will find all operators and timetables for a
Bus from St. Louis, MO to Detroit
What are the most popular stations in St. Louis, MO and Detroit?
In St. Louis, MO, you will usually depart from Gateway Station, Lindbergh @ Hackberry NB Bus Stop or Skinker Boulevard, while in Detroit you will be arriving at Central Bus Station, Amtrak or Park Avenue, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Detroit from St. Louis, MO? With 6 connections between 2 Flight and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between St. Louis, MO and Detroit, you can pay as low as $60 with a Bus from Greyhound US.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from United Airlines: you will get to Detroit in just 4h 31m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting St. Louis, MO and Detroit are FlixBus, Greyhound US and Frontier Airlines, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in St. Louis, MO and Detroit is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Sauget, IL or to Windsor, ON, and look at flights from St. Louis Lambert Airport, and landing at Detroit Metropolitan Wayne County Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from St. Louis, MO to Detroit?
The most popular companies between St. Louis, MO and Detroit, are FlixBus, Greyhound US and Frontier Airlines. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus and Greyhound US
Airlines: Frontier Airlines, United Airlines and Skyscanner
All you need to know when you travel from St. Louis, MO to Detroit
Check all information on comfort and services on all modes of transports from St. Louis, MO to Detroit. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from St. Louis, MO to Detroit
How can I reach Detroit from St. Louis, MO?
Every day, there are on average 6 connections between Flight and Bus, with which you can get to Detroit from St. Louis, MO.
How far is Detroit from St. Louis, MO?
The distance between St. Louis, MO and Detroit is 454.7 miles.
What is the most ecofriendly mode of transport between St. Louis, MO and Detroit?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 20 kgs of CO2, a train 26 kgs, a car 124 kgs, and a flight 180 kgs.
What is the cheapest mode of transport from St. Louis, MO to Detroit?
You can get to Detroit with just $60 by taking a Bus from Greyhound US.
What is the fastest way to get from St. Louis, MO to Detroit?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Detroit in just 4h 31m with a Flight from United Airlines.
More routes to St. Louis, MO and to Detroit
Looking for more options? Here you can see the most popular routes to St. Louis, MO and to Detroit. Simply click on a connection, and you’ll find all the details about the route!
