Bus Harrisburg, PA to Chicago: Compare prices and save money

Compare all timetables for the bus from Harrisburg, PA to Chicago

Here is a selection of the cheapest bus trips from the schedule from Harrisburg, PA to Chicago from various bus operators like Greyhound US or FlixBus for the next days.

today

tomorrow

$154

Wednesday

$129

Thursday

$111

Friday

$129

Saturday

Sunday

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	16h 30m	2:40 PM	Harrisburg, PA	Bus Station	6:10 AM	Chicago	Downtown Bus Station	Economy	$154	A Bus from FlixBus goes from Bus Station, Harrisburg, PA (USA) at 12/23/2025 2:40:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/24/2025 6:10:00 AM. 50 Economy ticket for $154 per person are available. Travel duration is 16h 30m
FlixBus	16h 0m	2:40 PM	Harrisburg, PA	Bus Station	5:40 AM	Chicago	95th Red Line Station	Economy	$154	A Bus from FlixBus goes from Bus Station, Harrisburg, PA (USA) at 12/23/2025 2:40:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/24/2025 5:40:00 AM. 50 Economy ticket for $154 per person are available. Travel duration is 16h 0m
Greyhound US	18h 10m	2:50 PM	Harrisburg, PA	Bus Station	8:00 AM	Chicago	Union Station	Economy	$167	A Bus from Greyhound US goes from Bus Station, Harrisburg, PA (USA) at 12/23/2025 2:50:00 PM to Union Station, Chicago (USA) arriving at 12/24/2025 8:00:00 AM. 50 Economy ticket for $167 per person are available. Travel duration is 18h 10m
Greyhound US	18h 35m	2:30 AM	Harrisburg, PA	Bus Station	8:05 PM	Chicago	Downtown Bus Station	Economy	$169	A Bus from Greyhound US goes from Bus Station, Harrisburg, PA (USA) at 12/23/2025 2:30:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/23/2025 8:05:00 PM. 50 Economy ticket for $169 per person are available. Travel duration is 18h 35m
Greyhound US	21h 30m	2:30 AM	Harrisburg, PA	Bus Station	11:00 PM	Chicago	95th Red Line Station	Economy	$172	A Bus from Greyhound US goes from Bus Station, Harrisburg, PA (USA) at 12/23/2025 2:30:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/23/2025 11:00:00 PM. 50 Economy ticket for $172 per person are available. Travel duration is 21h 30m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	16h 0m	2:40 PM	Harrisburg, PA	Bus Station	5:40 AM	Chicago	95th Red Line Station	Economy	$129	A Bus from FlixBus goes from Bus Station, Harrisburg, PA (USA) at 12/24/2025 2:40:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/25/2025 5:40:00 AM. 50 Economy ticket for $129 per person are available. Travel duration is 16h 0m
Greyhound US	18h 10m	8:15 PM	Harrisburg, PA	Bus Station	1:25 PM	Chicago	95th Red Line Station	Economy	$153	A Bus from Greyhound US goes from Bus Station, Harrisburg, PA (USA) at 12/24/2025 8:15:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/25/2025 1:25:00 PM. 50 Economy ticket for $153 per person are available. Travel duration is 18h 10m
Greyhound US	15h 50m	2:50 PM	Harrisburg, PA	Bus Station	5:40 AM	Chicago	95th Red Line Station	Economy	$155	A Bus from Greyhound US goes from Bus Station, Harrisburg, PA (USA) at 12/24/2025 2:50:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/25/2025 5:40:00 AM. 50 Economy ticket for $155 per person are available. Travel duration is 15h 50m
Greyhound US	26h 50m	9:10 PM	Harrisburg, PA	Bus Station	11:00 PM	Chicago	95th Red Line Station	Economy	$158	A Bus from Greyhound US goes from Bus Station, Harrisburg, PA (USA) at 12/24/2025 9:10:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/25/2025 11:00:00 PM. 50 Economy ticket for $158 per person are available. Travel duration is 26h 50m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	16h 30m	2:40 PM	Harrisburg, PA	Bus Station	6:10 AM	Chicago	Downtown Bus Station	Economy	$111	A Bus from FlixBus goes from Bus Station, Harrisburg, PA (USA) at 12/25/2025 2:40:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/26/2025 6:10:00 AM. 50 Economy ticket for $111 per person are available. Travel duration is 16h 30m
FlixBus	16h 0m	2:40 PM	Harrisburg, PA	Bus Station	5:40 AM	Chicago	95th Red Line Station	Economy	$122	A Bus from FlixBus goes from Bus Station, Harrisburg, PA (USA) at 12/25/2025 2:40:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/26/2025 5:40:00 AM. 50 Economy ticket for $122 per person are available. Travel duration is 16h 0m
Greyhound US	15h 50m	2:50 PM	Harrisburg, PA	Bus Station	5:40 AM	Chicago	95th Red Line Station	Economy	$132	A Bus from Greyhound US goes from Bus Station, Harrisburg, PA (USA) at 12/25/2025 2:50:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/26/2025 5:40:00 AM. 50 Economy ticket for $132 per person are available. Travel duration is 15h 50m
Greyhound US	18h 10m	8:15 PM	Harrisburg, PA	Bus Station	1:25 PM	Chicago	95th Red Line Station	Economy	$132	A Bus from Greyhound US goes from Bus Station, Harrisburg, PA (USA) at 12/25/2025 8:15:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/26/2025 1:25:00 PM. 50 Economy ticket for $132 per person are available. Travel duration is 18h 10m
Greyhound US	18h 35m	2:30 AM	Harrisburg, PA	Bus Station	8:05 PM	Chicago	Downtown Bus Station	Economy	$137	A Bus from Greyhound US goes from Bus Station, Harrisburg, PA (USA) at 12/25/2025 2:30:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/25/2025 8:05:00 PM. 50 Economy ticket for $137 per person are available. Travel duration is 18h 35m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	16h 30m	2:40 PM	Harrisburg, PA	Bus Station	6:10 AM	Chicago	Downtown Bus Station	Economy	$129	A Bus from FlixBus goes from Bus Station, Harrisburg, PA (USA) at 12/26/2025 2:40:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/27/2025 6:10:00 AM. 50 Economy ticket for $129 per person are available. Travel duration is 16h 30m
FlixBus	16h 0m	2:40 PM	Harrisburg, PA	Bus Station	5:40 AM	Chicago	95th Red Line Station	Economy	$137	A Bus from FlixBus goes from Bus Station, Harrisburg, PA (USA) at 12/26/2025 2:40:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/27/2025 5:40:00 AM. 50 Economy ticket for $137 per person are available. Travel duration is 16h 0m
Greyhound US	21h 30m	2:30 AM	Harrisburg, PA	Bus Station	11:00 PM	Chicago	95th Red Line Station	Economy	$144	A Bus from Greyhound US goes from Bus Station, Harrisburg, PA (USA) at 12/26/2025 2:30:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/26/2025 11:00:00 PM. 50 Economy ticket for $144 per person are available. Travel duration is 21h 30m
Greyhound US	18h 10m	8:15 PM	Harrisburg, PA	Bus Station	1:25 PM	Chicago	95th Red Line Station	Economy	$144	A Bus from Greyhound US goes from Bus Station, Harrisburg, PA (USA) at 12/26/2025 8:15:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/27/2025 1:25:00 PM. 50 Economy ticket for $144 per person are available. Travel duration is 18h 10m
Greyhound US	14h 45m	8:15 PM	Harrisburg, PA	Bus Station	10:00 AM	Chicago	Downtown Bus Station	Economy	$146	A Bus from Greyhound US goes from Bus Station, Harrisburg, PA (USA) at 12/26/2025 8:15:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/27/2025 10:00:00 AM. 50 Economy ticket for $146 per person are available. Travel duration is 14h 45m

Best Price Offer: The price for the cheapest bus from Harrisburg, PA to Chicago is $92 on 1/8/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Harrisburg, PA and Chicago

See here how frequent the connections between Harrisburg, PA and Chicago are, during different times and days of the week.

Thursday is the busiest day, with more than 20 daily buses from Harrisburg, PA to Chicago. Wednesday has instead the fewest connections, with only 5 daily coaches between Harrisburg, PA and Chicago.

The busiest time of the day is the Afternoon, with 22 buses from Harrisburg, PA to Chicago, while Night sees the fewest connections between Harrisburg, PA and Chicago, with 9 offers.

Facts about the bus from Harrisburg, PA to Chicago

Compare all providers like Greyhound US and FlixBus that travel 11 times every day by bus from Harrisburg, PA to Chicago in one click! Book your bus ticket from Harrisburg, PA to Chicago starting from $92!

Cheapest Bus	$92
Fastest Bus	13h 45m
Earliest Bus	2:30 AM
Latest Bus	9:10 PM
Daily Bus Routes	11 Ø
Distance	573.8 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from Harrisburg, PA to Chicago

Every day, 11 buses from 2 bus companies leave Harrisburg, PA for Chicago: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/22/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 12/21

Monday 12/22

Tuesday 12/23

$154

Wednesday 12/24

$129

Thursday 12/25

$111

Friday 12/26

$137

Saturday 12/27

Sunday 12/28

Monday 12/29

$133

Tuesday 12/30

Wednesday 12/31

Thursday 01/01

Friday 01/02

Saturday 01/03

Sunday 01/04

Monday 01/05

Tuesday 01/06

Wednesday 01/07

Thursday 01/08

$92

Friday 01/09

Saturday 01/10

Sunday 01/11

$100

Monday 01/12

Tuesday 01/13

Wednesday 01/14

Thursday 01/15

Friday 01/16

Saturday 01/17

The cheapest time to travel from Harrisburg, PA to Chicago

See here on which day and which time of the day you can find the cheapest bus ticket from Harrisburg, PA to Chicago, for the next 30 days.

With a price starting from $92, Thursday is the cheapest day for a bus from Harrisburg, PA to Chicago. Tuesday instead is the most expensive day with prices starting from $154.

Night is the cheapest day time for bus tickets from Harrisburg, PA to Chicago, with $92. Evening is the most expensive time of the day with prices starting from $132.

How to save money travelling from Harrisburg, PA to Chicago

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Harrisburg, PA to Chicago in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Harrisburg, PA to Chicago, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Harrisburg, PA to Chicago are also emptier.

All bus stations and stops in Harrisburg, PA and Chicago

In the map below, you can see where to find all bus stations in Harrisburg, PA and Chicago.

Bus Station

Market St 411

S 4th St & Chestnut St

N Cameron St

N Cameron St 2000

Mall Parking Lot

Paxton St 3501

Old Country Buffet

Jonestown Rd 5083

95th Red Line Station

W. 95th St 14

Downtown Bus Station

West Harrison Street 630-670

Union Station

S Canal St 225

Cumberland CTA

N Cumberland Ave 5800

Canal & Van Buren

S Canal St 310-320

Service and Comfort on the bus from Harrisburg, PA to Chicago

Want to know which seat classes are available on the buses from Harrisburg, PA to Chicago? Or which bus companies serve the route Harrisburg, PA to Chicago? Below you will find answers to your questions.

FAQs about the Harrisburg, PA to Chicago bus

How much does a Harrisburg, PA Chicago bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $92 and takes 15h 30m to reach Chicago. Compare offers to save money!

How much could I save by comparing buses from Harrisburg, PA to Chicago?

This route is offered by 2 companies with a range of ticket prices between $92 and $245. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Chicago.

On average, how many connections are available from Harrisburg, PA to Chicago each day?

Every day, the Harrisburg, PA to Chicago bus route is served by approximately 11 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Harrisburg, PA to Chicago take?

The fastest bus from Harrisburg, PA to Chicago is offered by Greyhound US and takes 13h 45m. Bus tickets for this connection cost $228. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Harrisburg, PA to Chicago?

The earliest bus arriving in Chicago from Harrisburg, PA starts at 2:30 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Harrisburg, PA to Chicago?

The latest bus trip departing from Harrisburg, PA for Chicago starts at 9:10 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Harrisburg, PA Chicago route?

When traveling by bus from Harrisburg, PA to Chicago, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Harrisburg, PA and Chicago?

You can check all the direct connections between Harrisburg, PA and Chicago by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Harrisburg, PA to Chicago bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Harrisburg, PA Chicago bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Harrisburg, PA Chicago bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Harrisburg, PA to Chicago on your planned travel date.

How does CheckMyBus find the best bus deals from Harrisburg, PA to Chicago?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 11 daily trips between Harrisburg, PA and Chicago. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Harrisburg, PA to Chicago?

Prices and availability for 11 trips between Harrisburg, PA and Chicago change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Harrisburg, PA to Chicago

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Harrisburg, PA and to Chicago

Here’s an overview of the most popular bus routes to Harrisburg, PA and to Chicago. Simply click on the connection of your choice, and you will find all the details about your bus route!