Bus Mexico City to Santiago Tuxtla - Compare all Companies

Compare all timetables for the bus from Mexico City to Santiago Tuxtla

Here is a selection of the cheapest bus trips from the schedule from Mexico City to Santiago Tuxtla from various bus operators like ADO for the next days.

today

tomorrow

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Thursday

$70

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
ADO	9h 15m	8:00 PM	Mexico City	Norte Bus Station	5:15 AM	Santiago Tuxtla	Central Bus Station	Economy	$70	A Bus from ADO goes from Norte Bus Station, Mexico City (Mexico) at 12/11/2025 8:00:00 PM to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 12/12/2025 5:15:00 AM. 50 Economy ticket for $70 per person are available. Travel duration is 9h 15m
ADO	9h 14m	11:10 PM	Mexico City	Norte Bus Station	8:24 AM	Santiago Tuxtla	Central Bus Station	Economy	$70	A Bus from ADO goes from Norte Bus Station, Mexico City (Mexico) at 12/11/2025 11:10:00 PM to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 12/12/2025 8:24:00 AM. 50 Economy ticket for $70 per person are available. Travel duration is 9h 14m
ADO	8h 15m	9:00 PM	Mexico City	Terminal de Autobuses de Oriente (TAPO)	5:15 AM	Santiago Tuxtla	Central Bus Station	Economy	$70	A Bus from ADO goes from Terminal de Autobuses de Oriente (TAPO), Mexico City (Mexico) at 12/11/2025 9:00:00 PM to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 12/12/2025 5:15:00 AM. 50 Economy ticket for $70 per person are available. Travel duration is 8h 15m
ADO	9h 0m	10:15 PM	Mexico City	Terminal de Autobuses de Oriente (TAPO)	7:15 AM	Santiago Tuxtla	Central Bus Station	Economy	$70	A Bus from ADO goes from Terminal de Autobuses de Oriente (TAPO), Mexico City (Mexico) at 12/11/2025 10:15:00 PM to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 12/12/2025 7:15:00 AM. 50 Economy ticket for $70 per person are available. Travel duration is 9h 0m
ADO	8h 25m	11:59 PM	Mexico City	Terminal de Autobuses de Oriente (TAPO)	8:24 AM	Santiago Tuxtla	Central Bus Station	Economy	$70	A Bus from ADO goes from Terminal de Autobuses de Oriente (TAPO), Mexico City (Mexico) at 12/11/2025 11:59:00 PM to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 12/12/2025 8:24:00 AM. 50 Economy ticket for $70 per person are available. Travel duration is 8h 25m

Did you know that if you travel from Mexico City to Santiago Tuxtla via Veracruz, you can save more than $20? You can find the corresponding connections below.
- ClickBus MX
  
  11h 35m
  
  0
  
  7:15 AM
  
  Mexico City
  Norte Bus Station
  
  2:57 PM
  
  Veracruz
  Bus Stop
  
  0
  
  Economy
  
  $32
  
  A Bus from ClickBus MX goes from Norte Bus Station, Mexico City (Mexico) at 12/6/2025 7:15:00 AM to Bus Stop, Veracruz (Mexico) arriving at 12/6/2025 2:57:00 PM. 50 Economy ticket for $32 per person are available. Travel duration is 7h 42m
- ClickBus MX
  
  3h 5m
  
  0
  
  3:45 PM
  
  Veracruz
  Central bus station
  
  6:50 PM
  
  Santiago Tuxtla
  Central Bus Station
  
  0
  
  Economy
  
  $18
  
  A Bus from ClickBus MX goes from Central bus station, Veracruz (Mexico) at 12/6/2025 3:45:00 PM to Central Bus Station, Santiago Tuxtla (Mexico) arriving at 12/6/2025 6:50:00 PM. 50 Economy ticket for $18 per person are available. Travel duration is 3h 5m
Travel time is 3h 20m longer, but you will save $20

Best Price Offer: The price for the cheapest bus from Mexico City to Santiago Tuxtla is $65 on 12/15/2025. Flexible travelers save on ticket prices.

Facts about the bus from Mexico City to Santiago Tuxtla

Compare all providers like ADO that travel 5 times every day by bus from Mexico City to Santiago Tuxtla in one click! Book your bus ticket from Mexico City to Santiago Tuxtla starting from $65!

Cheapest Bus	$65
Fastest Bus	8h 15m
Earliest Bus	8:00 PM
Latest Bus	11:59 PM
Daily Bus Routes	5 Ø
Distance	259.2 miles
Bus Companies	ADO

Cheapest bus connections from Mexico City to Santiago Tuxtla

Every day, 5 buses from 1 bus companies leave Mexico City for Santiago Tuxtla: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/05/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 11/30

Monday 12/01

Tuesday 12/02

Wednesday 12/03

Thursday 12/04

Friday 12/05

Saturday 12/06

Sunday 12/07

Monday 12/08

Tuesday 12/09

Wednesday 12/10

Thursday 12/11

$70

Friday 12/12

$70

Saturday 12/13

Sunday 12/14

Monday 12/15

$65

Tuesday 12/16

Wednesday 12/17

$69

Thursday 12/18

$66

Friday 12/19

$68

Saturday 12/20

$70

Sunday 12/21

Monday 12/22

$65

Tuesday 12/23

$68

Wednesday 12/24

Thursday 12/25

$68

Friday 12/26

Saturday 12/27

How to save money travelling from Mexico City to Santiago Tuxtla

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Mexico City to Santiago Tuxtla in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Mexico City to Santiago Tuxtla, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Mexico City to Santiago Tuxtla are also emptier.

Beloved bus companies from Mexico City to Santiago Tuxtla

These are the most booked bus companies between Mexico City to Santiago Tuxtla from our users.

ADO from Mexico City to Santiago Tuxtla

Here you will find the key facts about the ADO bus route Mexico City to Santiago Tuxtla:

Cheapest Price	$70
Fastest Bus	8h 15m
Earliest Bus	8:00 PM
Last Bus	11:59 PM
Daily Connections	5 Ø
Found on	11/28/2025

All bus stations and stops in Mexico City and Santiago Tuxtla

In the map below, you can see where to find all bus stations in Mexico City and Santiago Tuxtla.

Norte Bus Station

Eje Central Lázaro Cárdenas

Terminal de Autobuses de Oriente (TAPO)

Calz. Ignacio Zaragoza 200

Terminal del Sur

Av. Taxqueña 1320

Observatorio Central Bus Station

Av Río de Tacubaya 122 232

Terminal Antas Tla

Emiliano Zapata 97

Central Bus Station

Morelos 190

Service and Comfort on the bus from Mexico City to Santiago Tuxtla

Want to know which seat classes are available on the buses from Mexico City to Santiago Tuxtla? Or which bus companies serve the route Mexico City to Santiago Tuxtla? Below you will find answers to your questions.

FAQs about the Mexico City to Santiago Tuxtla bus

How much does a Mexico City Santiago Tuxtla bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $65 and takes 9h 15m to reach Santiago Tuxtla. Compare offers to save money!

How much could I save by comparing buses from Mexico City to Santiago Tuxtla?

This route is offered by 1 companies with a range of ticket prices between $65 and $70. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Santiago Tuxtla.

On average, how many connections are available from Mexico City to Santiago Tuxtla each day?

Every day, the Mexico City to Santiago Tuxtla bus route is served by approximately 5 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Mexico City to Santiago Tuxtla take?

The fastest bus from Mexico City to Santiago Tuxtla is offered by ADO and takes 8h 15m. Bus tickets for this connection cost $70. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Mexico City to Santiago Tuxtla?

The earliest bus arriving in Santiago Tuxtla from Mexico City starts at 8:00 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Mexico City to Santiago Tuxtla?

The latest bus trip departing from Mexico City for Santiago Tuxtla starts at 11:59 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Mexico City Santiago Tuxtla route?

When traveling by bus from Mexico City to Santiago Tuxtla, passengers can travel with ADO. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Mexico City and Santiago Tuxtla?

You can check all the direct connections between Mexico City and Santiago Tuxtla by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: ADO.

What can I take with me on the Mexico City to Santiago Tuxtla bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Mexico City Santiago Tuxtla bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Mexico City Santiago Tuxtla bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Mexico City to Santiago Tuxtla on your planned travel date.

Available seat classes which are offered on the bus route Mexico City to Santiago Tuxtla

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Mexico City and to Santiago Tuxtla

Here’s an overview of the most popular bus routes to Mexico City and to Santiago Tuxtla. Simply click on the connection of your choice, and you will find all the details about your bus route!