Which bus from Mexico City to Santiago Tuxtla is the cheapest?

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Compare all timetables for the bus from Mexico City to Santiago Tuxtla

Here is a selection of the cheapest bus trips from the schedule from Mexico City to Santiago Tuxtla from various bus operators like ADO for the next days.

today
$70
tomorrow
$70
Tuesday
$74
Wednesday
$70
Thursday
Friday
$70
Saturday

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
ADO 7h 55m 9:05 PM Mexico City Terminal de Autobuses de Oriente (TAPO) 5:00 AM Santiago Tuxtla Central Bus Station  Economy $70
ADO 8h 55m 10:15 PM Mexico City Terminal de Autobuses de Oriente (TAPO) 7:10 AM Santiago Tuxtla Central Bus Station  Economy $70
ADO 9h 0m 8:00 PM Mexico City Norte Bus Station 5:00 AM Santiago Tuxtla Central Bus Station  Economy $72
ADO 9h 19m 11:10 PM Mexico City Norte Bus Station 8:29 AM Santiago Tuxtla Central Bus Station  Economy $72
  • Did you know that if you travel from Mexico City to Santiago Tuxtla via Puebla City, PL, you can save more than $8? You can find the corresponding connections below.
    • Flix Mexico
      10h 20m
      0
      7:00 PM
      Mexico City
      Fórum Buenavista
      10:30 PM
      Puebla City, PL
      Central Bus Station (CAPU)
      0
      Flix Mexico
      Economy
      $5
      • Waiting Time 1h 5m
    • ADO
      5h 45m
      0
      11:35 PM
      Puebla City, PL
      Central Bus Station (CAPU)
      5:20 AM
      Santiago Tuxtla
      Central Bus Station
      0
      ADO
      Economy
      $57
    Travel time is 2h 25m longer, but you will save $8

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
ADO 8h 25m 12:04 AM Mexico City Terminal de Autobuses de Oriente (TAPO) 8:29 AM Santiago Tuxtla Central Bus Station  Economy $70
ADO 8h 15m 9:05 PM Mexico City Terminal de Autobuses de Oriente (TAPO) 5:20 AM Santiago Tuxtla Central Bus Station  Economy $70
ADO 8h 55m 10:15 PM Mexico City Terminal de Autobuses de Oriente (TAPO) 7:10 AM Santiago Tuxtla Central Bus Station  Economy $70
ADO 8h 25m 11:59 PM Mexico City Terminal de Autobuses de Oriente (TAPO) 8:24 AM Santiago Tuxtla Central Bus Station  Economy $70
ADO 9h 20m 8:00 PM Mexico City Norte Bus Station 5:20 AM Santiago Tuxtla Central Bus Station  Economy $70
  • Did you know that if you travel from Mexico City to Santiago Tuxtla via Puebla City, PL, you can save more than $8? You can find the corresponding connections below.
    • Flix Mexico
      10h 20m
      0
      7:00 PM
      Mexico City
      Fórum Buenavista
      10:30 PM
      Puebla City, PL
      Central Bus Station (CAPU)
      0
      Flix Mexico
      Economy
      $5
      • Waiting Time 1h 5m
    • ADO
      5h 45m
      0
      11:35 PM
      Puebla City, PL
      Central Bus Station (CAPU)
      5:20 AM
      Santiago Tuxtla
      Central Bus Station
      0
      ADO
      Economy
      $57
    Travel time is 2h 5m longer, but you will save $8

Cheapest bus trips Tuesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
ADO 9h 20m 8:00 PM Mexico City Norte Bus Station 5:20 AM Santiago Tuxtla Central Bus Station  Economy $74
ADO 9h 39m 11:10 PM Mexico City Norte Bus Station 8:49 AM Santiago Tuxtla Central Bus Station  Economy $74
ADO 8h 15m 9:05 PM Mexico City Terminal de Autobuses de Oriente (TAPO) 5:20 AM Santiago Tuxtla Central Bus Station  Economy $74
ADO 9h 0m 10:15 PM Mexico City Terminal de Autobuses de Oriente (TAPO) 7:15 AM Santiago Tuxtla Central Bus Station  Economy $74
  • Did you know that if you travel from Mexico City to Santiago Tuxtla via Veracruz, you can save more than $23? You can find the corresponding connections below.
    • Conexión
      10h 25m
      0
      6:50 AM
      Mexico City
      Norte Bus Station
      1:39 PM
      Veracruz
      Bus Stop
      0
      Conexión
      Economy
      $32
      • Waiting Time 0h 46m
    • ADO
      2h 50m
      0
      2:25 PM
      Veracruz
      Central bus station
      5:15 PM
      Santiago Tuxtla
      Central Bus Station
      0
      ADO
      Economy
      $19
    Travel time is 2h 10m longer, but you will save $23

Cheapest bus trips Wednesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
ADO 8h 45m 12:04 AM Mexico City Terminal de Autobuses de Oriente (TAPO) 8:49 AM Santiago Tuxtla Central Bus Station  Economy $70
ADO 8h 15m 9:00 PM Mexico City Terminal de Autobuses de Oriente (TAPO) 5:15 AM Santiago Tuxtla Central Bus Station  Economy $70
ADO 8h 55m 10:15 PM Mexico City Terminal de Autobuses de Oriente (TAPO) 7:10 AM Santiago Tuxtla Central Bus Station  Economy $70
ADO 9h 15m 8:00 PM Mexico City Norte Bus Station 5:15 AM Santiago Tuxtla Central Bus Station  Economy $70
ADO 9h 19m 11:10 PM Mexico City Norte Bus Station 8:29 AM Santiago Tuxtla Central Bus Station  Economy $70
  • Did you know that if you travel from Mexico City to Santiago Tuxtla via Veracruz, you can save more than $19? You can find the corresponding connections below.
    • Conexión
      10h 25m
      0
      6:50 AM
      Mexico City
      Norte Bus Station
      1:39 PM
      Veracruz
      Bus Stop
      0
      Conexión
      Economy
      $32
      • Waiting Time 0h 46m
    • ADO
      2h 50m
      0
      2:25 PM
      Veracruz
      Central bus station
      5:15 PM
      Santiago Tuxtla
      Central Bus Station
      0
      ADO
      Economy
      $19
    Travel time is 2h 10m longer, but you will save $19

Cheapest bus trips Friday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
ADO 8h 25m 12:04 AM Mexico City Terminal de Autobuses de Oriente (TAPO) 8:29 AM Santiago Tuxtla Central Bus Station  Economy $70
ADO 8h 15m 9:00 PM Mexico City Terminal de Autobuses de Oriente (TAPO) 5:15 AM Santiago Tuxtla Central Bus Station  Economy $70
ADO 8h 55m 10:15 PM Mexico City Terminal de Autobuses de Oriente (TAPO) 7:10 AM Santiago Tuxtla Central Bus Station  Economy $70
ADO 9h 0m 11:30 PM Mexico City Terminal de Autobuses de Oriente (TAPO) 8:30 AM Santiago Tuxtla Central Bus Station  Economy $70
ADO 9h 15m 8:00 PM Mexico City Norte Bus Station 5:15 AM Santiago Tuxtla Central Bus Station  Economy $70
  • Did you know that if you travel from Mexico City to Santiago Tuxtla via Veracruz, you can save more than $19? You can find the corresponding connections below.
    • Conexión
      10h 25m
      0
      6:50 AM
      Mexico City
      Norte Bus Station
      1:39 PM
      Veracruz
      Bus Stop
      0
      Conexión
      Economy
      $32
      • Waiting Time 0h 46m
    • ADO
      2h 50m
      0
      2:25 PM
      Veracruz
      Central bus station
      5:15 PM
      Santiago Tuxtla
      Central Bus Station
      0
      ADO
      Economy
      $19
    Travel time is 2h 10m longer, but you will save $19

Best Price Offer: The price for the cheapest bus from Mexico City to Santiago Tuxtla is $70 on 3/25/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Mexico City and Santiago Tuxtla

See here how frequent the connections between Mexico City and Santiago Tuxtla are, during different times and days of the week.
Monday is the busiest day, with more than 12 daily buses from Mexico City to Santiago Tuxtla. Tuesday has instead the fewest connections, with only 4 daily coaches between Mexico City and Santiago Tuxtla.
The busiest time of the day is the Evening, with 37 buses from Mexico City to Santiago Tuxtla, while Night sees the fewest connections between Mexico City and Santiago Tuxtla, with 6 offers.

Facts about the bus from Mexico City to Santiago Tuxtla

Compare all providers like ADO that travel 8 times every day by bus from Mexico City to Santiago Tuxtla in one click! Book your bus ticket from Mexico City to Santiago Tuxtla starting from $70!

Cheapest Bus $70
Fastest Bus 7h 55m
Earliest Bus 8:00 PM
Latest Bus 11:30 PM
Daily Bus Routes 8 Ø
Distance 259.2 miles
Bus Companies ADO

Cheapest bus connections from Mexico City to Santiago Tuxtla

Every day, 8 buses from 1 bus companies leave Mexico City for Santiago Tuxtla: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 03/22/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 03/22
$72
Monday 03/23
$72
Tuesday 03/24
$74
Wednesday 03/25
$70
Thursday 03/26
Friday 03/27
$70
Saturday 03/28
Sunday 03/29
Monday 03/30
$70
Tuesday 03/31
$70
Wednesday 04/01
Thursday 04/02
Friday 04/03
$70
Saturday 04/04
Sunday 04/05
$73
Monday 04/06
$70
Tuesday 04/07
$72
Wednesday 04/08
$70
Thursday 04/09
$73
Friday 04/10
$70
Saturday 04/11
$70
Sunday 04/12
$70
Monday 04/13
$71
Tuesday 04/14
Wednesday 04/15
$72
Thursday 04/16
$70
Friday 04/17
$73
Saturday 04/18

The cheapest time to travel from Mexico City to Santiago Tuxtla

See here on which day and which time of the day you can find the cheapest bus ticket from Mexico City to Santiago Tuxtla, for the next 30 days.
With a price starting from $70, Sunday is the cheapest day for a bus from Mexico City to Santiago Tuxtla. Tuesday instead is the most expensive day with prices starting from $70.
Evening is the cheapest day time for bus tickets from Mexico City to Santiago Tuxtla, with $70. Evening is the most expensive time of the day with prices starting from $70.

How to save money travelling from Mexico City to Santiago Tuxtla

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Mexico City to Santiago Tuxtla in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Mexico City to Santiago Tuxtla, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Mexico City to Santiago Tuxtla are also emptier.

Beloved bus companies from Mexico City to Santiago Tuxtla

These are the most booked bus companies between Mexico City to Santiago Tuxtla from our users.

ADO from Mexico City to Santiago Tuxtla

ADO

Here you will find the key facts about the ADO bus route Mexico City to Santiago Tuxtla:

Cheapest Price $70
Fastest Bus 7h 55m
Earliest Bus 8:00 PM
Last Bus 11:30 PM
Daily Connections 8 Ø
Found on 3/22/2026

All bus stations and stops in Mexico City and Santiago Tuxtla

In the map below, you can see where to find all bus stations in Mexico City and Santiago Tuxtla.

Service and Comfort on the bus from Mexico City to Santiago Tuxtla

Want to know which seat classes are available on the buses from Mexico City to Santiago Tuxtla? Or which bus companies serve the route Mexico City to Santiago Tuxtla? Below you will find answers to your questions.

FAQs about the Mexico City to Santiago Tuxtla bus

How much does a Mexico City Santiago Tuxtla bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $70 and takes 7h 55m to reach Santiago Tuxtla. Compare offers to save money!

How much could I save by comparing buses from Mexico City to Santiago Tuxtla?

This route is offered by 1 companies with a range of ticket prices between $70 and $74. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Santiago Tuxtla.

On average, how many connections are available from Mexico City to Santiago Tuxtla each day?

Every day, the Mexico City to Santiago Tuxtla bus route is served by approximately 8 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Mexico City to Santiago Tuxtla take?

The fastest bus from Mexico City to Santiago Tuxtla is offered by ADO and takes 7h 55m. Bus tickets for this connection cost $70. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Mexico City to Santiago Tuxtla?

The earliest bus arriving in Santiago Tuxtla from Mexico City starts at 8:00 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Mexico City to Santiago Tuxtla?

The latest bus trip departing from Mexico City for Santiago Tuxtla starts at 11:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Mexico City Santiago Tuxtla route?

When traveling by bus from Mexico City to Santiago Tuxtla, passengers can travel with ADO. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Mexico City and Santiago Tuxtla?

You can check all the direct connections between Mexico City and Santiago Tuxtla by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: ADO.

What can I take with me on the Mexico City to Santiago Tuxtla bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Mexico City Santiago Tuxtla bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Mexico City Santiago Tuxtla bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Mexico City to Santiago Tuxtla on your planned travel date.

How does CheckMyBus find the best bus deals from Mexico City to Santiago Tuxtla?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 8 daily trips between Mexico City and Santiago Tuxtla. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Mexico City to Santiago Tuxtla?

Prices and availability for 8 trips between Mexico City and Santiago Tuxtla change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Mexico City to Santiago Tuxtla

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Mexico City and to Santiago Tuxtla

Here’s an overview of the most popular bus routes to Mexico City and to Santiago Tuxtla. Simply click on the connection of your choice, and you will find all the details about your bus route!
Bus Puebla City, PL to Santiago Tuxtla Bus Puebla City, PL to Santiago Tuxtla
Veracruz to Santiago Tuxtla bus Veracruz to Santiago Tuxtla bus
Bus Villa Azueta, VZ - Mexico City Bus Villa Azueta, VZ - Mexico City
Bus Huejutla - Mexico City Bus Huejutla - Mexico City
Buses Ciudad Victoria to Mexico City Buses Ciudad Victoria to Mexico City
Buses from Uruapan, MN to Mexico City Buses from Uruapan, MN to Mexico City
Bus Pátzcuaro - Mexico City Bus Pátzcuaro - Mexico City
Buses to Mexico City from Palenque Buses to Mexico City from Palenque
Reynosa to Mexico City bus Reynosa to Mexico City bus
Matamoros to Mexico City bus Matamoros to Mexico City bus
From Cuautla to Mexico City bus From Cuautla to Mexico City bus
Bus from Hermosillo to Mexico City Bus from Hermosillo to Mexico City
From Ciudad Juárez to Mexico City bus From Ciudad Juárez to Mexico City bus
Bus Durango, DG to Mexico City Bus Durango, DG to Mexico City
Buses from Valle de Bravo, ME to Mexico City Buses from Valle de Bravo, ME to Mexico City
Bus to Mexico City from Toluca, ME Bus to Mexico City from Toluca, ME
Bus Acapulco, GR to Mexico City Bus Acapulco, GR to Mexico City
Bus from Puerto Escondido to Mexico City Bus from Puerto Escondido to Mexico City
Bus to Mexico City from Cuernavaca Bus to Mexico City from Cuernavaca
Bus from Tepoztlán to Mexico City Bus from Tepoztlán to Mexico City
Bus Guadalajara, JC - Mexico City Bus Guadalajara, JC - Mexico City
Buses to Mexico City from Tijuana, BC Buses to Mexico City from Tijuana, BC
Buses Puerto Vallarta to Mexico City Buses Puerto Vallarta to Mexico City
Buses Morelia to Mexico City Buses Morelia to Mexico City
Popular Airport Shuttles to Mexico City and to Santiago Tuxtla
CheckMyBus › Buses in Mexico › Bus to Mexico City › Bus to Santiago Tuxtla

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