Bus from Myrtle Beach, SC to Indianapolis from $126

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Compare all timetables for the bus from Myrtle Beach, SC to Indianapolis

Here is a selection of the cheapest bus trips from the schedule from Myrtle Beach, SC to Indianapolis from various bus operators like Greyhound US for the next days.
today
from $135
tomorrow
Friday
from $221
Saturday
from $126
Sunday
Monday
from $169
Tuesday

Cheapest bus trips today

Prices are for one way and one person
  • Greyhound US
    30h 30m
    0
    12:45 PM
    Myrtle Beach, SC
    Bus Stop
    7:15 PM
    Indianapolis
    Washington / Delaware
    0
    Greyhound US
    Economy
    $135
  • Greyhound US
    27h 50m
    0
    12:45 PM
    Myrtle Beach, SC
    Bus Stop
    4:35 PM
    Indianapolis
    Central Bus Station
    0
    Greyhound US
    Economy
    $135

Cheapest bus trips Friday

Prices are for one way and one person
  • Greyhound US
    30h 30m
    0
    12:45 PM
    Myrtle Beach, SC
    Bus Stop
    7:15 PM
    Indianapolis
    Washington / Delaware
    0
    Greyhound US
    Economy
    $221
  • Greyhound US
    27h 50m
    0
    12:45 PM
    Myrtle Beach, SC
    Bus Stop
    4:35 PM
    Indianapolis
    Central Bus Station
    0
    Greyhound US
    Economy
    $222
  • Did you know that if you travel from Myrtle Beach, SC to Indianapolis via Charlotte, you can save more than $74? You can find the corresponding connections below.
    • FlixBus
      32h 40m
      0
      12:45 PM
      Myrtle Beach, SC
      Bus Stop
      10:10 PM
      Charlotte
      W Trade St
      0
      FlixBus
      Economy
      $54
      • Waiting Time 6h 50m
    • Busbud
      16h 25m
      0
      5:00 AM
      Charlotte
      W Trade St
      9:25 PM
      Indianapolis
      Downtown Transit Center
      0
      Busbud
      Economy
      $93
    Travel time is 4h 50m longer, but you will save $74

Cheapest bus trips Saturday

Prices are for one way and one person
  • Greyhound US
    30h 30m
    0
    12:45 PM
    Myrtle Beach, SC
    Bus Stop
    7:15 PM
    Indianapolis
    Washington / Delaware
    0
    Greyhound US
    Economy
    $126
  • Greyhound US
    27h 50m
    0
    12:45 PM
    Myrtle Beach, SC
    Bus Stop
    4:35 PM
    Indianapolis
    Central Bus Station
    0
    Greyhound US
    Economy
    $126

Cheapest bus trips Monday

Prices are for one way and one person
  • Greyhound US
    30h 30m
    0
    12:45 PM
    Myrtle Beach, SC
    Bus Stop
    7:15 PM
    Indianapolis
    Washington / Delaware
    0
    Greyhound US
    Economy
    $169
  • Greyhound US
    27h 50m
    0
    12:45 PM
    Myrtle Beach, SC
    Bus Stop
    4:35 PM
    Indianapolis
    Central Bus Station
    0
    Greyhound US
    Economy
    $195
  • Did you know that if you travel from Myrtle Beach, SC to Indianapolis via Charlotte, you can save more than $22? You can find the corresponding connections below.
    • FlixBus
      32h 40m
      0
      12:45 PM
      Myrtle Beach, SC
      Bus Stop
      10:10 PM
      Charlotte
      W Trade St
      0
      FlixBus
      Economy
      $54
      • Waiting Time 6h 50m
    • Busbud
      16h 25m
      0
      5:00 AM
      Charlotte
      W Trade St
      9:25 PM
      Indianapolis
      Downtown Transit Center
      0
      Busbud
      Economy
      $93
    Travel time is 4h 50m longer, but you will save $22

Facts about the bus from Myrtle Beach, SC to Indianapolis

Compare all providers like Greyhound US that travel 2 times every day by bus from Myrtle Beach, SC to Indianapolis in one click! Book your bus ticket from Myrtle Beach, SC to Indianapolis starting from $126!

Cheapest Bus $126
Fastest Bus 27h 50m
Earliest Bus 12:45 PM
Latest Bus 12:45 PM
Daily Bus Routes 2 Ø
Distance 581.4 miles
Bus Companies Greyhound US

Cheapest bus connections from Myrtle Beach, SC to Indianapolis

Every day, 2 buses from 1 bus companies leave Myrtle Beach, SC for Indianapolis: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 06/18/2025 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 06/15
Monday 06/16
Tuesday 06/17
Wednesday 06/18
$135
Thursday 06/19
Friday 06/20
$220
Saturday 06/21
$126
Sunday 06/22
Monday 06/23
$169
Tuesday 06/24
Wednesday 06/25
Thursday 06/26
Friday 06/27
Saturday 06/28
Sunday 06/29
Monday 06/30
Tuesday 07/01
Wednesday 07/02
Thursday 07/03
Friday 07/04
Saturday 07/05
Sunday 07/06
Monday 07/07
Tuesday 07/08
Wednesday 07/09
Thursday 07/10
Friday 07/11
Saturday 07/12

How to save money travelling from Myrtle Beach, SC to Indianapolis

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Myrtle Beach, SC to Indianapolis in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Myrtle Beach, SC to Indianapolis, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Myrtle Beach, SC to Indianapolis are also emptier.

Beloved bus companies from Myrtle Beach, SC to Indianapolis

These are the most booked bus companies between Myrtle Beach, SC to Indianapolis from our users.

Greyhound US from Myrtle Beach, SC to Indianapolis

Greyhound US

Here you will find the key facts about the Greyhound US bus route Myrtle Beach, SC to Indianapolis:

Cheapest Price $126
Fastest Bus 27h 50m
Earliest Bus 12:45 PM
Last Bus 12:45 PM
Daily Connections 2 Ø
Found on 6/14/2025

All bus stations and stops in Myrtle Beach, SC and Indianapolis

In the map below, you can see where to find all bus stations in Myrtle Beach, SC and Indianapolis.

Service and Comfort on the bus from Myrtle Beach, SC to Indianapolis

Want to know which seat classes are available on the buses from Myrtle Beach, SC to Indianapolis? Or which bus companies serve the route Myrtle Beach, SC to Indianapolis? Below you will find answers to your questions.

FAQs about the Myrtle Beach, SC to Indianapolis bus

How much does a Myrtle Beach, SC Indianapolis bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $126 and takes 30h 30m to reach Indianapolis. Compare offers to save money!

How much could I save by comparing buses from Myrtle Beach, SC to Indianapolis?

This route is offered by 1 companies with a range of ticket prices between $126 and $222. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Indianapolis.

On average, how many connections are available from Myrtle Beach, SC to Indianapolis each day?

Every day, the Myrtle Beach, SC to Indianapolis bus route is served by approximately 2 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Myrtle Beach, SC to Indianapolis take?

The fastest bus from Myrtle Beach, SC to Indianapolis is offered by Greyhound US and takes 27h 50m. Bus tickets for this connection cost $135. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Myrtle Beach, SC to Indianapolis?

The earliest bus arriving in Indianapolis from Myrtle Beach, SC starts at 12:45 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Myrtle Beach, SC to Indianapolis?

The latest bus trip departing from Myrtle Beach, SC for Indianapolis starts at 12:45 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Myrtle Beach, SC Indianapolis route?

When traveling by bus from Myrtle Beach, SC to Indianapolis, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Myrtle Beach, SC and Indianapolis?

You can check all the direct connections between Myrtle Beach, SC and Indianapolis by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Myrtle Beach, SC to Indianapolis bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Myrtle Beach, SC Indianapolis bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Myrtle Beach, SC Indianapolis bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Myrtle Beach, SC to Indianapolis on your planned travel date.

Available seat classes which are offered on the bus route Myrtle Beach, SC to Indianapolis

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Myrtle Beach, SC and to Indianapolis

Here’s an overview of the most popular bus routes to Myrtle Beach, SC and to Indianapolis. Simply click on the connection of your choice, and you will find all the details about your bus route!
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