Bus Winston-Salem, NC to Indianapolis: Compare prices and save money

Compare all timetables for the bus from Winston-Salem, NC to Indianapolis

Here is a selection of the cheapest bus trips from the schedule from Winston-Salem, NC to Indianapolis from various bus operators like Greyhound US for the next days.

today

tomorrow

Tuesday

Wednesday

Thursday

Friday

$83

Saturday

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	21h 50m	6:55 AM	Winston-Salem, NC	Greyhound Bus Station	4:45 AM	Indianapolis	Central Bus Station	Economy	$83	A Bus from Greyhound US goes from Greyhound Bus Station, Winston-Salem, NC (USA) at 3/27/2026 6:55:00 AM to Central Bus Station, Indianapolis (USA) arriving at 3/28/2026 4:45:00 AM. 50 Economy ticket for $83 per person are available. Travel duration is 21h 50m
Greyhound US	19h 30m	4:35 PM	Winston-Salem, NC	Greyhound Bus Station	12:05 PM	Indianapolis	Central Bus Station	Economy	$83	A Bus from Greyhound US goes from Greyhound Bus Station, Winston-Salem, NC (USA) at 3/27/2026 4:35:00 PM to Central Bus Station, Indianapolis (USA) arriving at 3/28/2026 12:05:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 19h 30m
Greyhound US	22h 40m	5:55 PM	Winston-Salem, NC	Greyhound Bus Station	4:35 PM	Indianapolis	Central Bus Station	Economy	$83	A Bus from Greyhound US goes from Greyhound Bus Station, Winston-Salem, NC (USA) at 3/27/2026 5:55:00 PM to Central Bus Station, Indianapolis (USA) arriving at 3/28/2026 4:35:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 22h 40m
Greyhound US	26h 35m	7:10 AM	Winston-Salem, NC	Greyhound Bus Station	9:45 AM	Indianapolis	Central Bus Station	Economy	$84	A Bus from Greyhound US goes from Greyhound Bus Station, Winston-Salem, NC (USA) at 3/27/2026 7:10:00 AM to Central Bus Station, Indianapolis (USA) arriving at 3/28/2026 9:45:00 AM. 50 Economy ticket for $84 per person are available. Travel duration is 26h 35m
Greyhound US	22h 0m	10:25 AM	Winston-Salem, NC	Greyhound Bus Station	8:25 AM	Indianapolis	Washington / Delaware	Economy	$84	A Bus from Greyhound US goes from Greyhound Bus Station, Winston-Salem, NC (USA) at 3/27/2026 10:25:00 AM to Washington / Delaware, Indianapolis (USA) arriving at 3/28/2026 8:25:00 AM. 50 Economy ticket for $84 per person are available. Travel duration is 22h 0m

Best Price Offer: The price for the cheapest bus from Winston-Salem, NC to Indianapolis is $83 on 3/27/2026. Flexible travelers save on ticket prices.

Facts about the bus from Winston-Salem, NC to Indianapolis

Compare all providers like Greyhound US that travel 7 times every day by bus from Winston-Salem, NC to Indianapolis in one click! Book your bus ticket from Winston-Salem, NC to Indianapolis starting from $83!

Cheapest Bus	$83
Fastest Bus	19h 30m
Earliest Bus	6:55 AM
Latest Bus	5:55 PM
Daily Bus Routes	7 Ø
Distance	409.7 miles
Bus Companies	Greyhound US

Cheapest bus connections from Winston-Salem, NC to Indianapolis

Every day, 7 buses from 1 bus companies leave Winston-Salem, NC for Indianapolis: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 03/22/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 03/22

Monday 03/23

Tuesday 03/24

Wednesday 03/25

Thursday 03/26

Friday 03/27

$83

Saturday 03/28

Sunday 03/29

Monday 03/30

Tuesday 03/31

$110

Wednesday 04/01

Thursday 04/02

$98

Friday 04/03

Saturday 04/04

$96

Sunday 04/05

Monday 04/06

$106

Tuesday 04/07

$101

Wednesday 04/08

Thursday 04/09

$92

Friday 04/10

$83

Saturday 04/11

$91

Sunday 04/12

$90

Monday 04/13

$86

Tuesday 04/14

Wednesday 04/15

Thursday 04/16

$87

Friday 04/17

$92

Saturday 04/18

How to save money travelling from Winston-Salem, NC to Indianapolis

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Winston-Salem, NC to Indianapolis in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Winston-Salem, NC to Indianapolis, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Winston-Salem, NC to Indianapolis are also emptier.

Beloved bus companies from Winston-Salem, NC to Indianapolis

These are the most booked bus companies between Winston-Salem, NC to Indianapolis from our users.

Greyhound US from Winston-Salem, NC to Indianapolis

Here you will find the key facts about the Greyhound US bus route Winston-Salem, NC to Indianapolis:

Cheapest Price	$83
Fastest Bus	19h 30m
Earliest Bus	6:55 AM
Last Bus	5:55 PM
Daily Connections	7 Ø
Found on	2/24/2026

All bus stations and stops in Winston-Salem, NC and Indianapolis

In the map below, you can see where to find all bus stations in Winston-Salem, NC and Indianapolis.

Greyhound Bus Station

W 5th St 100

Forsyth Hospital

Silas Creek Pkwy 3333

Hong Kong King Buffet

Silas Creek Pkwy 1237

E Sprague St

E Sprague St 841

North Carolina Baptist Hospital

Queen St 2034-2020

Mile Square

Monument Circle 2250

Washington / Delaware

E Washington St between N Delaware St and N Alabama St

Central Bus Station

Greyhound Bus Station

S Illinois St 350

S Keystone Avenue

S Keystone Avenue 3649

Service and Comfort on the bus from Winston-Salem, NC to Indianapolis

Want to know which seat classes are available on the buses from Winston-Salem, NC to Indianapolis? Or which bus companies serve the route Winston-Salem, NC to Indianapolis? Below you will find answers to your questions.

FAQs about the Winston-Salem, NC to Indianapolis bus

How much does a Winston-Salem, NC Indianapolis bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $83 and takes 21h 50m to reach Indianapolis. Compare offers to save money!

How much could I save by comparing buses from Winston-Salem, NC to Indianapolis?

This route is offered by 1 companies with a range of ticket prices between $83 and $85. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Indianapolis.

On average, how many connections are available from Winston-Salem, NC to Indianapolis each day?

Every day, the Winston-Salem, NC to Indianapolis bus route is served by approximately 7 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Winston-Salem, NC to Indianapolis take?

The fastest bus from Winston-Salem, NC to Indianapolis is offered by Greyhound US and takes 19h 30m. Bus tickets for this connection cost $83. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Winston-Salem, NC to Indianapolis?

The earliest bus arriving in Indianapolis from Winston-Salem, NC starts at 6:55 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Winston-Salem, NC to Indianapolis?

The latest bus trip departing from Winston-Salem, NC for Indianapolis starts at 5:55 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Winston-Salem, NC Indianapolis route?

When traveling by bus from Winston-Salem, NC to Indianapolis, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Winston-Salem, NC and Indianapolis?

You can check all the direct connections between Winston-Salem, NC and Indianapolis by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Winston-Salem, NC to Indianapolis bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Winston-Salem, NC Indianapolis bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Winston-Salem, NC Indianapolis bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Winston-Salem, NC to Indianapolis on your planned travel date.

How does CheckMyBus find the best bus deals from Winston-Salem, NC to Indianapolis?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 7 daily trips between Winston-Salem, NC and Indianapolis. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Winston-Salem, NC to Indianapolis?

Prices and availability for 7 trips between Winston-Salem, NC and Indianapolis change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Winston-Salem, NC to Indianapolis

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Winston-Salem, NC and to Indianapolis

Here’s an overview of the most popular bus routes to Winston-Salem, NC and to Indianapolis. Simply click on the connection of your choice, and you will find all the details about your bus route!