Bus San Antonio, TX to Winston-Salem, NC

Compare all timetables for the bus from San Antonio, TX to Winston-Salem, NC

Here is a selection of the cheapest bus trips from the schedule from San Antonio, TX to Winston-Salem, NC from various bus operators like FlixBus, Greyhound US or Greyhound Lines Mexico for the next days.

today

tomorrow

Friday

$117

Saturday

$127

Sunday

$115

Monday

$106

Tuesday

$115

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	27h 45m	10:00 AM	San Antonio, TX	Bus Station	2:45 PM	Winston-Salem, NC	Greyhound Bus Station	Economy	$117	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 5/8/2026 10:00:00 AM to Greyhound Bus Station, Winston-Salem, NC (USA) arriving at 5/9/2026 2:45:00 PM. 50 Economy ticket for $117 per person are available. Travel duration is 27h 45m
FlixBus	32h 45m	9:15 PM	San Antonio, TX	Bus Station	7:00 AM	Winston-Salem, NC	Greyhound Bus Station	Economy	$117	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 5/8/2026 9:15:00 PM to Greyhound Bus Station, Winston-Salem, NC (USA) arriving at 5/10/2026 7:00:00 AM. 50 Economy ticket for $117 per person are available. Travel duration is 32h 45m
FlixBus	46h 15m	7:45 AM	San Antonio, TX	Pearl District	7:00 AM	Winston-Salem, NC	Greyhound Bus Station	Economy	$118	A Bus from FlixBus goes from Pearl District, San Antonio, TX (USA) at 5/8/2026 7:45:00 AM to Greyhound Bus Station, Winston-Salem, NC (USA) arriving at 5/10/2026 7:00:00 AM. 50 Economy ticket for $118 per person are available. Travel duration is 46h 15m
Greyhound US	28h 55m	1:05 AM	San Antonio, TX	Bus Station	7:00 AM	Winston-Salem, NC	Greyhound Bus Station	Economy	$182	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 5/8/2026 1:05:00 AM to Greyhound Bus Station, Winston-Salem, NC (USA) arriving at 5/9/2026 7:00:00 AM. 50 Economy ticket for $182 per person are available. Travel duration is 28h 55m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	28h 55m	1:05 AM	San Antonio, TX	Bus Station	7:00 AM	Winston-Salem, NC	Greyhound Bus Station	Economy	$127	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 5/9/2026 1:05:00 AM to Greyhound Bus Station, Winston-Salem, NC (USA) arriving at 5/10/2026 7:00:00 AM. 50 Economy ticket for $127 per person are available. Travel duration is 28h 55m
FlixBus	27h 45m	10:00 AM	San Antonio, TX	Bus Station	2:45 PM	Winston-Salem, NC	Greyhound Bus Station	Economy	$127	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 5/9/2026 10:00:00 AM to Greyhound Bus Station, Winston-Salem, NC (USA) arriving at 5/10/2026 2:45:00 PM. 50 Economy ticket for $127 per person are available. Travel duration is 27h 45m
FlixBus	46h 15m	7:45 AM	San Antonio, TX	Pearl District	7:00 AM	Winston-Salem, NC	Greyhound Bus Station	Economy	$127	A Bus from FlixBus goes from Pearl District, San Antonio, TX (USA) at 5/9/2026 7:45:00 AM to Greyhound Bus Station, Winston-Salem, NC (USA) arriving at 5/11/2026 7:00:00 AM. 50 Economy ticket for $127 per person are available. Travel duration is 46h 15m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	28h 55m	1:05 AM	San Antonio, TX	Bus Station	7:00 AM	Winston-Salem, NC	Greyhound Bus Station	Economy	$115	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 5/10/2026 1:05:00 AM to Greyhound Bus Station, Winston-Salem, NC (USA) arriving at 5/11/2026 7:00:00 AM. 50 Economy ticket for $115 per person are available. Travel duration is 28h 55m
FlixBus	27h 45m	10:00 AM	San Antonio, TX	Bus Station	2:45 PM	Winston-Salem, NC	Greyhound Bus Station	Economy	$115	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 5/10/2026 10:00:00 AM to Greyhound Bus Station, Winston-Salem, NC (USA) arriving at 5/11/2026 2:45:00 PM. 50 Economy ticket for $115 per person are available. Travel duration is 27h 45m
FlixBus	32h 45m	9:15 PM	San Antonio, TX	Bus Station	7:00 AM	Winston-Salem, NC	Greyhound Bus Station	Economy	$115	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 5/10/2026 9:15:00 PM to Greyhound Bus Station, Winston-Salem, NC (USA) arriving at 5/12/2026 7:00:00 AM. 50 Economy ticket for $115 per person are available. Travel duration is 32h 45m
FlixBus	46h 15m	7:45 AM	San Antonio, TX	Pearl District	7:00 AM	Winston-Salem, NC	Greyhound Bus Station	Economy	$115	A Bus from FlixBus goes from Pearl District, San Antonio, TX (USA) at 5/10/2026 7:45:00 AM to Greyhound Bus Station, Winston-Salem, NC (USA) arriving at 5/12/2026 7:00:00 AM. 50 Economy ticket for $115 per person are available. Travel duration is 46h 15m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	28h 55m	1:05 AM	San Antonio, TX	Bus Station	7:00 AM	Winston-Salem, NC	Greyhound Bus Station	Economy	$106	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 5/11/2026 1:05:00 AM to Greyhound Bus Station, Winston-Salem, NC (USA) arriving at 5/12/2026 7:00:00 AM. 50 Economy ticket for $106 per person are available. Travel duration is 28h 55m
FlixBus	46h 15m	7:45 AM	San Antonio, TX	Pearl District	7:00 AM	Winston-Salem, NC	Greyhound Bus Station	Economy	$108	A Bus from FlixBus goes from Pearl District, San Antonio, TX (USA) at 5/11/2026 7:45:00 AM to Greyhound Bus Station, Winston-Salem, NC (USA) arriving at 5/13/2026 7:00:00 AM. 50 Economy ticket for $108 per person are available. Travel duration is 46h 15m
FlixBus	27h 45m	10:00 AM	San Antonio, TX	Bus Station	2:45 PM	Winston-Salem, NC	Greyhound Bus Station	Economy	$109	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 5/11/2026 10:00:00 AM to Greyhound Bus Station, Winston-Salem, NC (USA) arriving at 5/12/2026 2:45:00 PM. 50 Economy ticket for $109 per person are available. Travel duration is 27h 45m
Greyhound Lines Mexico	34h 45m	7:15 PM	San Antonio, TX	Bus Station	7:00 AM	Winston-Salem, NC	Greyhound Bus Station	Economy	$109	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 5/11/2026 7:15:00 PM to Greyhound Bus Station, Winston-Salem, NC (USA) arriving at 5/13/2026 7:00:00 AM. 50 Economy ticket for $109 per person are available. Travel duration is 34h 45m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	28h 55m	1:05 AM	San Antonio, TX	Bus Station	7:00 AM	Winston-Salem, NC	Greyhound Bus Station	Economy	$115	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 5/12/2026 1:05:00 AM to Greyhound Bus Station, Winston-Salem, NC (USA) arriving at 5/13/2026 7:00:00 AM. 50 Economy ticket for $115 per person are available. Travel duration is 28h 55m
Greyhound US	30h 10m	7:35 AM	San Antonio, TX	Bus Station	2:45 PM	Winston-Salem, NC	Greyhound Bus Station	Economy	$115	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 5/12/2026 7:35:00 AM to Greyhound Bus Station, Winston-Salem, NC (USA) arriving at 5/13/2026 2:45:00 PM. 50 Economy ticket for $115 per person are available. Travel duration is 30h 10m
Greyhound Lines Mexico	34h 45m	7:15 PM	San Antonio, TX	Bus Station	7:00 AM	Winston-Salem, NC	Greyhound Bus Station	Economy	$127	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 5/12/2026 7:15:00 PM to Greyhound Bus Station, Winston-Salem, NC (USA) arriving at 5/14/2026 7:00:00 AM. 50 Economy ticket for $127 per person are available. Travel duration is 34h 45m

Best Price Offer: The price for the cheapest bus from San Antonio, TX to Winston-Salem, NC is $104 on 5/15/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between San Antonio, TX and Winston-Salem, NC

See here how frequent the connections between San Antonio, TX and Winston-Salem, NC are, during different times and days of the week.

Tuesday is the busiest day, with more than 6 daily buses from San Antonio, TX to Winston-Salem, NC. Saturday has instead the fewest connections, with only 3 daily coaches between San Antonio, TX and Winston-Salem, NC.

The busiest time of the day is the Morning, with 10 buses from San Antonio, TX to Winston-Salem, NC, while Evening sees the fewest connections between San Antonio, TX and Winston-Salem, NC, with 5 offers.

Facts about the bus from San Antonio, TX to Winston-Salem, NC

Compare all providers like FlixBus, Greyhound US and Greyhound Lines Mexico that travel 4 times every day by bus from San Antonio, TX to Winston-Salem, NC in one click! Book your bus ticket from San Antonio, TX to Winston-Salem, NC starting from $104!

Cheapest Bus	$104
Fastest Bus	28h 45m
Earliest Bus	1:05 AM
Latest Bus	7:15 PM
Daily Bus Routes	4 Ø
Distance	1,153.7 miles
Bus Companies	FlixBus, Greyhound US and Greyhound Lines Mexico

Cheapest bus connections from San Antonio, TX to Winston-Salem, NC

Every day, 4 buses from 3 bus companies leave San Antonio, TX for Winston-Salem, NC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 05/06/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 05/03

Monday 05/04

Tuesday 05/05

Wednesday 05/06

Thursday 05/07

Friday 05/08

$117

Saturday 05/09

$127

Sunday 05/10

$115

Monday 05/11

$106

Tuesday 05/12

$115

Wednesday 05/13

$117

Thursday 05/14

$105

Friday 05/15

$104

Saturday 05/16

Sunday 05/17

Monday 05/18

$118

Tuesday 05/19

$141

Wednesday 05/20

Thursday 05/21

$127

Friday 05/22

$119

Saturday 05/23

Sunday 05/24

$116

Monday 05/25

$123

Tuesday 05/26

Wednesday 05/27

Thursday 05/28

$119

Friday 05/29

$120

Saturday 05/30

The cheapest time to travel from San Antonio, TX to Winston-Salem, NC

See here on which day and which time of the day you can find the cheapest bus ticket from San Antonio, TX to Winston-Salem, NC, for the next 30 days.

With a price starting from $104, Friday is the cheapest day for a bus from San Antonio, TX to Winston-Salem, NC. Saturday instead is the most expensive day with prices starting from $124.

Night is the cheapest day time for bus tickets from San Antonio, TX to Winston-Salem, NC, with $104. Evening is the most expensive time of the day with prices starting from $109.

How to save money travelling from San Antonio, TX to Winston-Salem, NC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from San Antonio, TX to Winston-Salem, NC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from San Antonio, TX to Winston-Salem, NC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from San Antonio, TX to Winston-Salem, NC are also emptier.

All bus stations and stops in San Antonio, TX and Winston-Salem, NC

In the map below, you can see where to find all bus stations in San Antonio, TX and Winston-Salem, NC.

Bus Station

N St Mary's St 500

San Antonio

Pearl District

Avenue A 699-599

Commerce & Bowie Bus Stop

W. Southcross & Buffalo Bus Stop

Greyhound Bus Station

W 5th St 100

Forsyth Hospital

Silas Creek Pkwy 3333

Hong Kong King Buffet

Silas Creek Pkwy 1237

E Sprague St

E Sprague St 841

North Carolina Baptist Hospital

Queen St 2034-2020

Service and Comfort on the bus from San Antonio, TX to Winston-Salem, NC

Want to know which seat classes are available on the buses from San Antonio, TX to Winston-Salem, NC? Or which bus companies serve the route San Antonio, TX to Winston-Salem, NC? Below you will find answers to your questions.

FAQs about the San Antonio, TX to Winston-Salem, NC bus

How much does a San Antonio, TX Winston-Salem, NC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $104 and takes 29h 55m to reach Winston-Salem, NC. Compare offers to save money!

How much could I save by comparing buses from San Antonio, TX to Winston-Salem, NC?

This route is offered by 3 companies with a range of ticket prices between $104 and $182. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Winston-Salem, NC.

On average, how many connections are available from San Antonio, TX to Winston-Salem, NC each day?

Every day, the San Antonio, TX to Winston-Salem, NC bus route is served by approximately 4 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from San Antonio, TX to Winston-Salem, NC take?

The fastest bus from San Antonio, TX to Winston-Salem, NC is offered by FlixBus and takes 28h 45m. Bus tickets for this connection cost $117. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from San Antonio, TX to Winston-Salem, NC?

The earliest bus arriving in Winston-Salem, NC from San Antonio, TX starts at 1:05 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from San Antonio, TX to Winston-Salem, NC?

The latest bus trip departing from San Antonio, TX for Winston-Salem, NC starts at 7:15 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the San Antonio, TX Winston-Salem, NC route?

When traveling by bus from San Antonio, TX to Winston-Salem, NC, passengers can travel with FlixBus, Greyhound US and Greyhound Lines Mexico. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between San Antonio, TX and Winston-Salem, NC?

You can check all the direct connections between San Antonio, TX and Winston-Salem, NC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus, Greyhound US and Greyhound Lines Mexico.

What can I take with me on the San Antonio, TX to Winston-Salem, NC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the San Antonio, TX Winston-Salem, NC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the San Antonio, TX Winston-Salem, NC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from San Antonio, TX to Winston-Salem, NC on your planned travel date.

How does CheckMyBus find the best bus deals from San Antonio, TX to Winston-Salem, NC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 4 daily trips between San Antonio, TX and Winston-Salem, NC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from San Antonio, TX to Winston-Salem, NC?

Prices and availability for 4 trips between San Antonio, TX and Winston-Salem, NC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route San Antonio, TX to Winston-Salem, NC

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to San Antonio, TX and to Winston-Salem, NC

Here’s an overview of the most popular bus routes to San Antonio, TX and to Winston-Salem, NC. Simply click on the connection of your choice, and you will find all the details about your bus route!