Bus Wilmington, DE to Winston-Salem, NC

Compare all timetables for the bus from Wilmington, DE to Winston-Salem, NC

Here is a selection of the cheapest bus trips from the schedule from Wilmington, DE to Winston-Salem, NC from various bus operators like Greyhound US for the next days.

today

tomorrow

$64

Tuesday

$61

Wednesday

Thursday

Friday

$74

Saturday

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	13h 35m	1:45 AM	Wilmington, DE	Greyhound	3:20 PM	Winston-Salem, NC	Greyhound Bus Station	Economy	$64	A Bus from Greyhound US goes from Greyhound, Wilmington, DE (USA) at 10/19/2026 1:45:00 AM to Greyhound Bus Station, Winston-Salem, NC (USA) arriving at 10/19/2026 3:20:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 13h 35m
Greyhound US	16h 55m	1:50 PM	Wilmington, DE	Greyhound	6:45 AM	Winston-Salem, NC	Greyhound Bus Station	Economy	$64	A Bus from Greyhound US goes from Greyhound, Wilmington, DE (USA) at 10/19/2026 1:50:00 PM to Greyhound Bus Station, Winston-Salem, NC (USA) arriving at 10/20/2026 6:45:00 AM. 50 Economy ticket for $64 per person are available. Travel duration is 16h 55m
Greyhound US	17h 35m	9:45 PM	Wilmington, DE	Greyhound	3:20 PM	Winston-Salem, NC	Greyhound Bus Station	Economy	$64	A Bus from Greyhound US goes from Greyhound, Wilmington, DE (USA) at 10/19/2026 9:45:00 PM to Greyhound Bus Station, Winston-Salem, NC (USA) arriving at 10/20/2026 3:20:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 17h 35m
Greyhound US	13h 40m	12:55 AM	Wilmington, DE	Greyhound	2:35 PM	Winston-Salem, NC	Greyhound Bus Station	Economy	$65	A Bus from Greyhound US goes from Greyhound, Wilmington, DE (USA) at 10/19/2026 12:55:00 AM to Greyhound Bus Station, Winston-Salem, NC (USA) arriving at 10/19/2026 2:35:00 PM. 50 Economy ticket for $65 per person are available. Travel duration is 13h 40m
Greyhound US	18h 25m	8:10 PM	Wilmington, DE	Greyhound	2:35 PM	Winston-Salem, NC	Greyhound Bus Station	Economy	$65	A Bus from Greyhound US goes from Greyhound, Wilmington, DE (USA) at 10/19/2026 8:10:00 PM to Greyhound Bus Station, Winston-Salem, NC (USA) arriving at 10/20/2026 2:35:00 PM. 50 Economy ticket for $65 per person are available. Travel duration is 18h 25m

Did you know that if you travel from Wilmington, DE to Winston-Salem, NC via Washington, DC, you can save more than $7? You can find the corresponding connections below.
- Greyhound US
  
  13h 40m
  
  0
  
  12:55 AM
  
  Wilmington, DE
  Greyhound
  
  3:20 AM
  
  Washington, DC
  Union Station
  
  0
  
  Economy
  
  $15
  
  A Bus from Greyhound US goes from Greyhound, Wilmington, DE (USA) at 10/21/2026 12:55:00 AM to Union Station, Washington, DC (USA) arriving at 10/21/2026 3:20:00 AM. 50 Economy ticket for $15 per person are available. Travel duration is 2h 25m
- Greyhound US
  
  10h 45m
  
  0
  
  3:50 AM
  
  Washington, DC
  Union Station
  
  2:35 PM
  
  Winston-Salem, NC
  Greyhound Bus Station
  
  0
  
  Economy
  
  $42
  
  A Bus from Greyhound US goes from Union Station, Washington, DC (USA) at 10/21/2026 3:50:00 AM to Greyhound Bus Station, Winston-Salem, NC (USA) arriving at 10/21/2026 2:35:00 PM. 50 Economy ticket for $42 per person are available. Travel duration is 10h 45m
Travel time is 0h 5m longer, but you will save $7

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	13h 40m	12:55 AM	Wilmington, DE	Greyhound	2:35 PM	Winston-Salem, NC	Greyhound Bus Station	Economy	$61	A Bus from Greyhound US goes from Greyhound, Wilmington, DE (USA) at 10/20/2026 12:55:00 AM to Greyhound Bus Station, Winston-Salem, NC (USA) arriving at 10/20/2026 2:35:00 PM. 50 Economy ticket for $61 per person are available. Travel duration is 13h 40m
Greyhound US	13h 35m	1:45 AM	Wilmington, DE	Greyhound	3:20 PM	Winston-Salem, NC	Greyhound Bus Station	Economy	$61	A Bus from Greyhound US goes from Greyhound, Wilmington, DE (USA) at 10/20/2026 1:45:00 AM to Greyhound Bus Station, Winston-Salem, NC (USA) arriving at 10/20/2026 3:20:00 PM. 50 Economy ticket for $61 per person are available. Travel duration is 13h 35m
Greyhound US	18h 25m	8:10 PM	Wilmington, DE	Greyhound	2:35 PM	Winston-Salem, NC	Greyhound Bus Station	Economy	$61	A Bus from Greyhound US goes from Greyhound, Wilmington, DE (USA) at 10/20/2026 8:10:00 PM to Greyhound Bus Station, Winston-Salem, NC (USA) arriving at 10/21/2026 2:35:00 PM. 50 Economy ticket for $61 per person are available. Travel duration is 18h 25m
Greyhound US	17h 35m	9:45 PM	Wilmington, DE	Greyhound	3:20 PM	Winston-Salem, NC	Greyhound Bus Station	Economy	$62	A Bus from Greyhound US goes from Greyhound, Wilmington, DE (USA) at 10/20/2026 9:45:00 PM to Greyhound Bus Station, Winston-Salem, NC (USA) arriving at 10/21/2026 3:20:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 17h 35m
Greyhound US	16h 55m	1:50 PM	Wilmington, DE	Greyhound	6:45 AM	Winston-Salem, NC	Greyhound Bus Station	Economy	$90	A Bus from Greyhound US goes from Greyhound, Wilmington, DE (USA) at 10/20/2026 1:50:00 PM to Greyhound Bus Station, Winston-Salem, NC (USA) arriving at 10/21/2026 6:45:00 AM. 50 Economy ticket for $90 per person are available. Travel duration is 16h 55m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	18h 25m	8:10 PM	Wilmington, DE	Greyhound	2:35 PM	Winston-Salem, NC	Greyhound Bus Station	Economy	$74	A Bus from Greyhound US goes from Greyhound, Wilmington, DE (USA) at 10/23/2026 8:10:00 PM to Greyhound Bus Station, Winston-Salem, NC (USA) arriving at 10/24/2026 2:35:00 PM. 50 Economy ticket for $74 per person are available. Travel duration is 18h 25m
Greyhound US	17h 35m	9:45 PM	Wilmington, DE	Greyhound	3:20 PM	Winston-Salem, NC	Greyhound Bus Station	Economy	$74	A Bus from Greyhound US goes from Greyhound, Wilmington, DE (USA) at 10/23/2026 9:45:00 PM to Greyhound Bus Station, Winston-Salem, NC (USA) arriving at 10/24/2026 3:20:00 PM. 50 Economy ticket for $74 per person are available. Travel duration is 17h 35m
Greyhound US	13h 35m	1:45 AM	Wilmington, DE	Greyhound	3:20 PM	Winston-Salem, NC	Greyhound Bus Station	Economy	$75	A Bus from Greyhound US goes from Greyhound, Wilmington, DE (USA) at 10/23/2026 1:45:00 AM to Greyhound Bus Station, Winston-Salem, NC (USA) arriving at 10/23/2026 3:20:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 13h 35m
Greyhound US	16h 55m	1:50 PM	Wilmington, DE	Greyhound	6:45 AM	Winston-Salem, NC	Greyhound Bus Station	Economy	$75	A Bus from Greyhound US goes from Greyhound, Wilmington, DE (USA) at 10/23/2026 1:50:00 PM to Greyhound Bus Station, Winston-Salem, NC (USA) arriving at 10/24/2026 6:45:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 16h 55m
Greyhound US	13h 40m	12:55 AM	Wilmington, DE	Greyhound	2:35 PM	Winston-Salem, NC	Greyhound Bus Station	Economy	$84	A Bus from Greyhound US goes from Greyhound, Wilmington, DE (USA) at 10/23/2026 12:55:00 AM to Greyhound Bus Station, Winston-Salem, NC (USA) arriving at 10/23/2026 2:35:00 PM. 50 Economy ticket for $84 per person are available. Travel duration is 13h 40m

Did you know that if you travel from Wilmington, DE to Winston-Salem, NC via Washington, DC, you can save more than $17? You can find the corresponding connections below.
- Greyhound US
  
  13h 40m
  
  0
  
  12:55 AM
  
  Wilmington, DE
  Greyhound
  
  3:20 AM
  
  Washington, DC
  Union Station
  
  0
  
  Economy
  
  $15
  
  A Bus from Greyhound US goes from Greyhound, Wilmington, DE (USA) at 10/21/2026 12:55:00 AM to Union Station, Washington, DC (USA) arriving at 10/21/2026 3:20:00 AM. 50 Economy ticket for $15 per person are available. Travel duration is 2h 25m
- Greyhound US
  
  10h 45m
  
  0
  
  3:50 AM
  
  Washington, DC
  Union Station
  
  2:35 PM
  
  Winston-Salem, NC
  Greyhound Bus Station
  
  0
  
  Economy
  
  $42
  
  A Bus from Greyhound US goes from Union Station, Washington, DC (USA) at 10/21/2026 3:50:00 AM to Greyhound Bus Station, Winston-Salem, NC (USA) arriving at 10/21/2026 2:35:00 PM. 50 Economy ticket for $42 per person are available. Travel duration is 10h 45m
Travel time is 0h 5m longer, but you will save $17

Best Price Offer: The price for the cheapest bus from Wilmington, DE to Winston-Salem, NC is $61 on 10/20/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Wilmington, DE and Winston-Salem, NC

See here how frequent the connections between Wilmington, DE and Winston-Salem, NC are, during different times and days of the week.

Monday is the busiest day, with more than 5 daily buses from Wilmington, DE to Winston-Salem, NC. Monday has instead the fewest connections, with only 5 daily coaches between Wilmington, DE and Winston-Salem, NC.

The busiest time of the day is the Evening, with 6 buses from Wilmington, DE to Winston-Salem, NC, while Afternoon sees the fewest connections between Wilmington, DE and Winston-Salem, NC, with 3 offers.

Facts about the bus from Wilmington, DE to Winston-Salem, NC

Compare all providers like Greyhound US that travel 5 times every day by bus from Wilmington, DE to Winston-Salem, NC in one click! Book your bus ticket from Wilmington, DE to Winston-Salem, NC starting from $61!

Cheapest Bus	$61
Fastest Bus	13h 35m
Earliest Bus	12:55 AM
Latest Bus	9:45 PM
Daily Bus Routes	5 Ø
Distance	359.1 miles
Bus Companies	Greyhound US

Cheapest bus connections from Wilmington, DE to Winston-Salem, NC

Every day, 5 buses from 1 bus companies leave Wilmington, DE for Winston-Salem, NC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 10/18/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 10/18

Monday 10/19

$64

Tuesday 10/20

$61

Wednesday 10/21

Thursday 10/22

Friday 10/23

$74

Saturday 10/24

Sunday 10/25

Monday 10/26

Tuesday 10/27

$66

Wednesday 10/28

$70

Thursday 10/29

Friday 10/30

Saturday 10/31

Sunday 11/01

Monday 11/02

Tuesday 11/03

Wednesday 11/04

Thursday 11/05

$69

Friday 11/06

$68

Saturday 11/07

Sunday 11/08

$72

Monday 11/09

Tuesday 11/10

$80

Wednesday 11/11

$68

Thursday 11/12

Friday 11/13

Saturday 11/14

The cheapest time to travel from Wilmington, DE to Winston-Salem, NC

See here on which day and which time of the day you can find the cheapest bus ticket from Wilmington, DE to Winston-Salem, NC, for the next 30 days.

With a price starting from $61, Tuesday is the cheapest day for a bus from Wilmington, DE to Winston-Salem, NC. Friday instead is the most expensive day with prices starting from $68.

Evening is the cheapest day time for bus tickets from Wilmington, DE to Winston-Salem, NC, with $61. Afternoon is the most expensive time of the day with prices starting from $64.

How to save money travelling from Wilmington, DE to Winston-Salem, NC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Wilmington, DE to Winston-Salem, NC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Wilmington, DE to Winston-Salem, NC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Wilmington, DE to Winston-Salem, NC are also emptier.

Beloved bus companies from Wilmington, DE to Winston-Salem, NC

These are the most booked bus companies between Wilmington, DE to Winston-Salem, NC from our users.

Greyhound US from Wilmington, DE to Winston-Salem, NC

Here you will find the key facts about the Greyhound US bus route Wilmington, DE to Winston-Salem, NC:

Cheapest Price	$61
Fastest Bus	13h 35m
Earliest Bus	12:55 AM
Last Bus	9:45 PM
Daily Connections	5 Ø
Found on	9/23/2026

All bus stations and stops in Wilmington, DE and Winston-Salem, NC

In the map below, you can see where to find all bus stations in Wilmington, DE and Winston-Salem, NC.

Amtrak Station

French Street 100

Greyhound

French St 101

Dupont Park

W 11th Street between Washington Street and West Street

Rockledge Bus

W 4th St 3

N King St

N King St. 315

Greyhound Bus Station

W 5th St 100

Forsyth Hospital

Silas Creek Pkwy 3333

E Sprague St

E Sprague St 841

North Carolina Baptist Hospital

Queen St 2034-2020

Hicks St.

Service and Comfort on the bus from Wilmington, DE to Winston-Salem, NC

Want to know which seat classes are available on the buses from Wilmington, DE to Winston-Salem, NC? Or which bus companies serve the route Wilmington, DE to Winston-Salem, NC? Below you will find answers to your questions.

FAQs about the Wilmington, DE to Winston-Salem, NC bus

How much does a Wilmington, DE Winston-Salem, NC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $61 and takes 13h 40m to reach Winston-Salem, NC. Compare offers to save money!

How much could I save by comparing buses from Wilmington, DE to Winston-Salem, NC?

This route is offered by 1 companies with a range of ticket prices between $61 and $90. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Winston-Salem, NC.

On average, how many connections are available from Wilmington, DE to Winston-Salem, NC each day?

Every day, the Wilmington, DE to Winston-Salem, NC bus route is served by approximately 5 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Wilmington, DE to Winston-Salem, NC take?

The fastest bus from Wilmington, DE to Winston-Salem, NC is offered by Greyhound US and takes 13h 35m. Bus tickets for this connection cost $64. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Wilmington, DE to Winston-Salem, NC?

The earliest bus arriving in Winston-Salem, NC from Wilmington, DE starts at 12:55 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Wilmington, DE to Winston-Salem, NC?

The latest bus trip departing from Wilmington, DE for Winston-Salem, NC starts at 9:45 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Wilmington, DE Winston-Salem, NC route?

When traveling by bus from Wilmington, DE to Winston-Salem, NC, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Wilmington, DE and Winston-Salem, NC?

You can check all the direct connections between Wilmington, DE and Winston-Salem, NC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Wilmington, DE to Winston-Salem, NC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Wilmington, DE Winston-Salem, NC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Wilmington, DE Winston-Salem, NC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Wilmington, DE to Winston-Salem, NC on your planned travel date.

How does CheckMyBus find the best bus deals from Wilmington, DE to Winston-Salem, NC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 5 daily trips between Wilmington, DE and Winston-Salem, NC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Wilmington, DE to Winston-Salem, NC?

Prices and availability for 5 trips between Wilmington, DE and Winston-Salem, NC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Wilmington, DE to Winston-Salem, NC

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Wilmington, DE and to Winston-Salem, NC

Here’s an overview of the most popular bus routes to Wilmington, DE and to Winston-Salem, NC. Simply click on the connection of your choice, and you will find all the details about your bus route!