Bus Orlando, FL to Winston-Salem, NC

Compare all timetables for the bus from Orlando, FL to Winston-Salem, NC

Here is a selection of the cheapest bus trips from the schedule from Orlando, FL to Winston-Salem, NC from various bus operators like FlixBus for the next days.

today

$104

tomorrow

Tuesday

Wednesday

Thursday

Friday

Saturday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	18h 0m	12:45 PM	Orlando, FL	Florida Mall	6:45 AM	Winston-Salem, NC	Greyhound Bus Station	Economy	$104	A Bus from FlixBus goes from Florida Mall, Orlando, FL (USA) at 3/22/2026 12:45:00 PM to Greyhound Bus Station, Winston-Salem, NC (USA) arriving at 3/23/2026 6:45:00 AM. 50 Economy ticket for $104 per person are available. Travel duration is 18h 0m
FlixBus	15h 5m	3:40 PM	Orlando, FL	Bus Station	6:45 AM	Winston-Salem, NC	Greyhound Bus Station	Economy	$104	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 3/22/2026 3:40:00 PM to Greyhound Bus Station, Winston-Salem, NC (USA) arriving at 3/23/2026 6:45:00 AM. 50 Economy ticket for $104 per person are available. Travel duration is 15h 5m
FlixBus	15h 50m	10:55 PM	Orlando, FL	Bus Station	2:45 PM	Winston-Salem, NC	Greyhound Bus Station	Economy	$104	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 3/22/2026 10:55:00 PM to Greyhound Bus Station, Winston-Salem, NC (USA) arriving at 3/23/2026 2:45:00 PM. 50 Economy ticket for $104 per person are available. Travel duration is 15h 50m
FlixBus	17h 0m	2:00 PM	Orlando, FL	Florida Mall	7:00 AM	Winston-Salem, NC	Greyhound Bus Station	Economy	$110	A Bus from FlixBus goes from Florida Mall, Orlando, FL (USA) at 3/22/2026 2:00:00 PM to Greyhound Bus Station, Winston-Salem, NC (USA) arriving at 3/23/2026 7:00:00 AM. 50 Economy ticket for $110 per person are available. Travel duration is 17h 0m

Did you know that if you travel from Orlando, FL to Winston-Salem, NC via Charlotte, you can save more than $29? You can find the corresponding connections below.
- FlixBus
  
  16h 30m
  
  0
  
  2:30 PM
  
  Orlando, FL
  Bus Station
  
  12:30 AM
  
  Charlotte
  W Trade St
  
  0
  
  Economy
  
  $65
  
  A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 3/23/2026 2:30:00 PM to W Trade St, Charlotte (USA) arriving at 3/24/2026 12:30:00 AM. 50 Economy ticket for $65 per person are available. Travel duration is 10h 0m
- Greyhound US
  
  1h 40m
  
  0
  
  5:20 AM
  
  Charlotte
  W Trade St
  
  7:00 AM
  
  Winston-Salem, NC
  Greyhound Bus Station
  
  0
  
  Economy
  
  $10
  
  A Bus from Greyhound US goes from W Trade St, Charlotte (USA) at 3/24/2026 5:20:00 AM to Greyhound Bus Station, Winston-Salem, NC (USA) arriving at 3/24/2026 7:00:00 AM. 50 Economy ticket for $10 per person are available. Travel duration is 1h 40m
Travel time is 1h 25m longer, but you will save $29

Best Price Offer: The price for the cheapest bus from Orlando, FL to Winston-Salem, NC is $85 on 4/16/2026. Flexible travelers save on ticket prices.

Facts about the bus from Orlando, FL to Winston-Salem, NC

Compare all providers like FlixBus that travel 4 times every day by bus from Orlando, FL to Winston-Salem, NC in one click! Book your bus ticket from Orlando, FL to Winston-Salem, NC starting from $85!

Cheapest Bus	$85
Fastest Bus	15h 5m
Earliest Bus	12:45 PM
Latest Bus	10:55 PM
Daily Bus Routes	4 Ø
Distance	526.6 miles
Bus Companies	FlixBus

Cheapest bus connections from Orlando, FL to Winston-Salem, NC

Every day, 4 buses from 1 bus companies leave Orlando, FL for Winston-Salem, NC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 03/22/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 03/22

$104

Monday 03/23

Tuesday 03/24

Wednesday 03/25

Thursday 03/26

Friday 03/27

Saturday 03/28

Sunday 03/29

$91

Monday 03/30

Tuesday 03/31

Wednesday 04/01

Thursday 04/02

Friday 04/03

Saturday 04/04

Sunday 04/05

$94

Monday 04/06

Tuesday 04/07

Wednesday 04/08

$101

Thursday 04/09

$94

Friday 04/10

$97

Saturday 04/11

Sunday 04/12

Monday 04/13

Tuesday 04/14

$101

Wednesday 04/15

$89

Thursday 04/16

$85

Friday 04/17

$85

Saturday 04/18

How to save money travelling from Orlando, FL to Winston-Salem, NC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Orlando, FL to Winston-Salem, NC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Orlando, FL to Winston-Salem, NC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Orlando, FL to Winston-Salem, NC are also emptier.

All bus stations and stops in Orlando, FL and Winston-Salem, NC

In the map below, you can see where to find all bus stations in Orlando, FL and Winston-Salem, NC.

Bus Station

N John Young Pkwy 555

Florida Mall

Florida Mall Avenue 1602

RedCoach Station

Belle Isle

Universal Studio Orlando Resort

Universal Blvd 5800

Seaworld Hotels

International Dr 10100

Greyhound Bus Station

W 5th St 100

Forsyth Hospital

Silas Creek Pkwy 3333

Hong Kong King Buffet

Silas Creek Pkwy 1237

E Sprague St

E Sprague St 841

North Carolina Baptist Hospital

Queen St 2034-2020

Service and Comfort on the bus from Orlando, FL to Winston-Salem, NC

Want to know which seat classes are available on the buses from Orlando, FL to Winston-Salem, NC? Or which bus companies serve the route Orlando, FL to Winston-Salem, NC? Below you will find answers to your questions.

FAQs about the Orlando, FL to Winston-Salem, NC bus

How much does a Orlando, FL Winston-Salem, NC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $85 and takes 18h 0m to reach Winston-Salem, NC. Compare offers to save money!

How much could I save by comparing buses from Orlando, FL to Winston-Salem, NC?

This route is offered by 1 companies with a range of ticket prices between $85 and $110. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Winston-Salem, NC.

On average, how many connections are available from Orlando, FL to Winston-Salem, NC each day?

Every day, the Orlando, FL to Winston-Salem, NC bus route is served by approximately 4 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Orlando, FL to Winston-Salem, NC take?

The fastest bus from Orlando, FL to Winston-Salem, NC is offered by FlixBus and takes 15h 5m. Bus tickets for this connection cost $104. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Orlando, FL to Winston-Salem, NC?

The earliest bus arriving in Winston-Salem, NC from Orlando, FL starts at 12:45 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Orlando, FL to Winston-Salem, NC?

The latest bus trip departing from Orlando, FL for Winston-Salem, NC starts at 10:55 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Orlando, FL Winston-Salem, NC route?

When traveling by bus from Orlando, FL to Winston-Salem, NC, passengers can travel with FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Orlando, FL and Winston-Salem, NC?

You can check all the direct connections between Orlando, FL and Winston-Salem, NC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus.

What can I take with me on the Orlando, FL to Winston-Salem, NC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Orlando, FL Winston-Salem, NC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Orlando, FL Winston-Salem, NC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Orlando, FL to Winston-Salem, NC on your planned travel date.

How does CheckMyBus find the best bus deals from Orlando, FL to Winston-Salem, NC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 4 daily trips between Orlando, FL and Winston-Salem, NC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Orlando, FL to Winston-Salem, NC?

Prices and availability for 4 trips between Orlando, FL and Winston-Salem, NC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Orlando, FL to Winston-Salem, NC

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Orlando, FL and to Winston-Salem, NC

Here’s an overview of the most popular bus routes to Orlando, FL and to Winston-Salem, NC. Simply click on the connection of your choice, and you will find all the details about your bus route!