What is the best way to travel from Chicago to San Antonio, TX?
Looking for a trip? Compare all the available Buses and Flights for the journey to San Antonio, TX from Chicago. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 3 available companies to find your perfect trip!
What is the cheapest way to reach San Antonio, TX from Chicago?
You can get to San Antonio, TX with just $116 by taking a Flight from Frontier Airlines, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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Frontier Airlines17h 29m02:26 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center7:55 AMSan Antonio AirportSan Antonio Airport0EconomyA Flight from Frontier Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/13/2025 2:26:00 PM to San Antonio Airport, San Antonio Airport (USA) arriving at 12/14/2025 7:55:00 AM. 50 Economy ticket for $118 per person are available. Travel duration is 17h 29m
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Spirit Airlines6h 55m07:20 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center2:15 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from Spirit Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/13/2025 7:20:00 AM to San Antonio Airport, San Antonio Airport (USA) arriving at 12/13/2025 2:15:00 PM. 50 Economy ticket for $248 per person are available. Travel duration is 6h 55m
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United Airlines3h 13m09:15 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center12:28 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/13/2025 9:15:00 AM to San Antonio Airport, San Antonio Airport (USA) arriving at 12/13/2025 12:28:00 PM. 50 Economy ticket for $391 per person are available. Travel duration is 3h 13m
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Skyscanner3h 17m01:20 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center4:37 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/13/2025 1:20:00 PM to San Antonio Airport, San Antonio Airport (USA) arriving at 12/13/2025 4:37:00 PM. 50 Economy ticket for $391 per person are available. Travel duration is 3h 17m
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Alaska Airlines31h 59m010:00 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center5:59 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from Alaska Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/13/2025 10:00:00 AM to San Antonio Airport, San Antonio Airport (USA) arriving at 12/14/2025 5:59:00 PM. 50 Economy ticket for $557 per person are available. Travel duration is 31h 59m
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FlixBus28h 30m07:25 PMChicago95th Red Line Station11:55 PMSan Antonio, TXBus Station0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 12/13/2025 7:25:00 PM to Bus Station, San Antonio, TX (USA) arriving at 12/14/2025 11:55:00 PM. 50 Economy ticket for $161 per person are available. Travel duration is 28h 30m
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FlixBus37h 5m011:50 PMChicago95th Red Line Station12:55 PMSan Antonio, TXBus Station0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 12/13/2025 11:50:00 PM to Bus Station, San Antonio, TX (USA) arriving at 12/15/2025 12:55:00 PM. 50 Economy ticket for $161 per person are available. Travel duration is 37h 5m
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Greyhound US47h 45m011:40 PMChicago95th Red Line Station11:25 PMSan Antonio, TXPearl District0EconomyA Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 12/13/2025 11:40:00 PM to Pearl District, San Antonio, TX (USA) arriving at 12/15/2025 11:25:00 PM. 50 Economy ticket for $161 per person are available. Travel duration is 47h 45m
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Tornado Bus Company23h 15m01:30 PMChicagoCalifornia & 35th Street Bus Stop12:45 PMSan Antonio, TXTornado Bus Company0BasicA Bus from Tornado Bus Company goes from California & 35th Street Bus Stop, Chicago (USA) at 12/13/2025 1:30:00 PM to Tornado Bus Company, San Antonio, TX (USA) arriving at 12/14/2025 12:45:00 PM. 50 Basic ticket for $285 per person are available. Travel duration is 23h 15m
Cheapest Flights Saturday
Cheapest Buses Saturday
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Frontier Airlines6h 27m010:24 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center4:51 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from Frontier Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/14/2025 10:24:00 AM to San Antonio Airport, San Antonio Airport (USA) arriving at 12/14/2025 4:51:00 PM. 50 Economy ticket for $116 per person are available. Travel duration is 6h 27m
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Spirit Airlines6h 55m07:20 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center2:15 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from Spirit Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/14/2025 7:20:00 AM to San Antonio Airport, San Antonio Airport (USA) arriving at 12/14/2025 2:15:00 PM. 50 Economy ticket for $244 per person are available. Travel duration is 6h 55m
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United Airlines3h 13m09:15 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center12:28 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/14/2025 9:15:00 AM to San Antonio Airport, San Antonio Airport (USA) arriving at 12/14/2025 12:28:00 PM. 50 Economy ticket for $466 per person are available. Travel duration is 3h 13m
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Skyscanner3h 17m01:20 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center4:37 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/14/2025 1:20:00 PM to San Antonio Airport, San Antonio Airport (USA) arriving at 12/14/2025 4:37:00 PM. 50 Economy ticket for $466 per person are available. Travel duration is 3h 17m
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Alaska Airlines24h 8m05:51 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center5:59 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from Alaska Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/14/2025 5:51:00 PM to San Antonio Airport, San Antonio Airport (USA) arriving at 12/15/2025 5:59:00 PM. 50 Economy ticket for $557 per person are available. Travel duration is 24h 8m
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FlixBus31h 10m05:45 AMChicago95th Red Line Station12:55 PMSan Antonio, TXBus Station0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 12/14/2025 5:45:00 AM to Bus Station, San Antonio, TX (USA) arriving at 12/15/2025 12:55:00 PM. 50 Economy ticket for $151 per person are available. Travel duration is 31h 10m
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FlixBus28h 30m07:25 PMChicago95th Red Line Station11:55 PMSan Antonio, TXBus Station0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 12/14/2025 7:25:00 PM to Bus Station, San Antonio, TX (USA) arriving at 12/15/2025 11:55:00 PM. 50 Economy ticket for $151 per person are available. Travel duration is 28h 30m
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Greyhound US47h 45m011:40 PMChicago95th Red Line Station11:25 PMSan Antonio, TXPearl District0EconomyA Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 12/14/2025 11:40:00 PM to Pearl District, San Antonio, TX (USA) arriving at 12/16/2025 11:25:00 PM. 50 Economy ticket for $154 per person are available. Travel duration is 47h 45m
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Tornado Bus Company23h 45m01:30 PMChicagoCalifornia & 35th Street Bus Stop1:15 PMSan Antonio, TXTornado Bus Company0BasicA Bus from Tornado Bus Company goes from California & 35th Street Bus Stop, Chicago (USA) at 12/14/2025 1:30:00 PM to Tornado Bus Company, San Antonio, TX (USA) arriving at 12/15/2025 1:15:00 PM. 50 Basic ticket for $285 per person are available. Travel duration is 23h 45m
Cheapest Flights Sunday
Cheapest Buses Sunday
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Greyhound US46h 40m010:30 PMChicagoDowntown Bus Station9:10 PMSan Antonio, TXPearl District0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/15/2025 10:30:00 PM to Pearl District, San Antonio, TX (USA) arriving at 12/17/2025 9:10:00 PM. 50 Economy ticket for $185 per person are available. Travel duration is 46h 40m
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Greyhound US30h 45m06:10 AMChicagoDowntown Bus Station12:55 PMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/15/2025 6:10:00 AM to Bus Station, San Antonio, TX (USA) arriving at 12/16/2025 12:55:00 PM. 50 Economy ticket for $188 per person are available. Travel duration is 30h 45m
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Greyhound US31h 55m09:40 AMChicagoDowntown Bus Station5:35 PMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/15/2025 9:40:00 AM to Bus Station, San Antonio, TX (USA) arriving at 12/16/2025 5:35:00 PM. 50 Economy ticket for $188 per person are available. Travel duration is 31h 55m
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Greyhound US31h 35m010:00 AMChicagoUnion Station5:35 PMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 12/15/2025 10:00:00 AM to Bus Station, San Antonio, TX (USA) arriving at 12/16/2025 5:35:00 PM. 50 Economy ticket for $188 per person are available. Travel duration is 31h 35m
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Greyhound US40h 10m011:10 PMChicagoUnion Station3:20 PMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 12/15/2025 11:10:00 PM to Bus Station, San Antonio, TX (USA) arriving at 12/17/2025 3:20:00 PM. 50 Economy ticket for $188 per person are available. Travel duration is 40h 10m
Cheapest Buses Monday
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Greyhound US25h 25m010:30 PMChicagoDowntown Bus Station11:55 PMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/16/2025 10:30:00 PM to Bus Station, San Antonio, TX (USA) arriving at 12/17/2025 11:55:00 PM. 50 Economy ticket for $187 per person are available. Travel duration is 25h 25m
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Greyhound US40h 10m011:10 PMChicagoUnion Station3:20 PMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 12/16/2025 11:10:00 PM to Bus Station, San Antonio, TX (USA) arriving at 12/18/2025 3:20:00 PM. 50 Economy ticket for $188 per person are available. Travel duration is 40h 10m
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Greyhound US31h 55m09:40 AMChicagoDowntown Bus Station5:35 PMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/16/2025 9:40:00 AM to Bus Station, San Antonio, TX (USA) arriving at 12/17/2025 5:35:00 PM. 50 Economy ticket for $204 per person are available. Travel duration is 31h 55m
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Greyhound US31h 35m010:00 AMChicagoUnion Station5:35 PMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 12/16/2025 10:00:00 AM to Bus Station, San Antonio, TX (USA) arriving at 12/17/2025 5:35:00 PM. 50 Economy ticket for $204 per person are available. Travel duration is 31h 35m
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Greyhound US30h 45m06:10 AMChicagoDowntown Bus Station12:55 PMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/16/2025 6:10:00 AM to Bus Station, San Antonio, TX (USA) arriving at 12/17/2025 12:55:00 PM. 50 Economy ticket for $212 per person are available. Travel duration is 30h 45m
Cheapest Buses Tuesday
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Greyhound US48h 35m010:50 PMChicagoDowntown Bus Station11:25 PMSan Antonio, TXPearl District0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/18/2025 10:50:00 PM to Pearl District, San Antonio, TX (USA) arriving at 12/20/2025 11:25:00 PM. 50 Economy ticket for $217 per person are available. Travel duration is 48h 35m
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Greyhound US48h 15m011:10 PMChicagoUnion Station11:25 PMSan Antonio, TXPearl District0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 12/18/2025 11:10:00 PM to Pearl District, San Antonio, TX (USA) arriving at 12/20/2025 11:25:00 PM. 50 Economy ticket for $217 per person are available. Travel duration is 48h 15m
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FlixBus37h 40m09:45 AMChicagoDowntown Bus Station11:25 PMSan Antonio, TXPearl District0EconomyA Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 12/18/2025 9:45:00 AM to Pearl District, San Antonio, TX (USA) arriving at 12/19/2025 11:25:00 PM. 50 Economy ticket for $221 per person are available. Travel duration is 37h 40m
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FlixBus27h 10m09:45 AMChicagoDowntown Bus Station12:55 PMSan Antonio, TXBus Station0EconomyA Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 12/18/2025 9:45:00 AM to Bus Station, San Antonio, TX (USA) arriving at 12/19/2025 12:55:00 PM. 50 Economy ticket for $235 per person are available. Travel duration is 27h 10m
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Greyhound US31h 35m010:00 AMChicagoUnion Station5:35 PMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 12/18/2025 10:00:00 AM to Bus Station, San Antonio, TX (USA) arriving at 12/19/2025 5:35:00 PM. 50 Economy ticket for $237 per person are available. Travel duration is 31h 35m
Cheapest Buses Thursday
What are the fastest trips from Chicago to San Antonio, TX?
You can get to San Antonio, TX from Chicago in just 3h 13m with a Flight from United Airlines. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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United Airlines3h 13m09:15 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center12:28 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/13/2025 9:15:00 AM to San Antonio Airport, San Antonio Airport (USA) arriving at 12/13/2025 12:28:00 PM. 50 Economy ticket for $391 per person are available. Travel duration is 3h 13m
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Skyscanner3h 17m01:20 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center4:37 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/13/2025 1:20:00 PM to San Antonio Airport, San Antonio Airport (USA) arriving at 12/13/2025 4:37:00 PM. 50 Economy ticket for $391 per person are available. Travel duration is 3h 17m
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Spirit Airlines6h 55m07:20 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center2:15 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from Spirit Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/13/2025 7:20:00 AM to San Antonio Airport, San Antonio Airport (USA) arriving at 12/13/2025 2:15:00 PM. 50 Economy ticket for $248 per person are available. Travel duration is 6h 55m
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Frontier Airlines17h 29m02:26 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center7:55 AMSan Antonio AirportSan Antonio Airport0EconomyA Flight from Frontier Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/13/2025 2:26:00 PM to San Antonio Airport, San Antonio Airport (USA) arriving at 12/14/2025 7:55:00 AM. 50 Economy ticket for $118 per person are available. Travel duration is 17h 29m
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Alaska Airlines31h 59m010:00 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center5:59 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from Alaska Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/13/2025 10:00:00 AM to San Antonio Airport, San Antonio Airport (USA) arriving at 12/14/2025 5:59:00 PM. 50 Economy ticket for $557 per person are available. Travel duration is 31h 59m
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Tornado Bus Company23h 15m01:30 PMChicagoCalifornia & 35th Street Bus Stop12:45 PMSan Antonio, TXTornado Bus Company0BasicA Bus from Tornado Bus Company goes from California & 35th Street Bus Stop, Chicago (USA) at 12/13/2025 1:30:00 PM to Tornado Bus Company, San Antonio, TX (USA) arriving at 12/14/2025 12:45:00 PM. 50 Basic ticket for $285 per person are available. Travel duration is 23h 15m
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FlixBus28h 30m07:25 PMChicago95th Red Line Station11:55 PMSan Antonio, TXBus Station0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 12/13/2025 7:25:00 PM to Bus Station, San Antonio, TX (USA) arriving at 12/14/2025 11:55:00 PM. 50 Economy ticket for $161 per person are available. Travel duration is 28h 30m
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FlixBus37h 5m011:50 PMChicago95th Red Line Station12:55 PMSan Antonio, TXBus Station0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 12/13/2025 11:50:00 PM to Bus Station, San Antonio, TX (USA) arriving at 12/15/2025 12:55:00 PM. 50 Economy ticket for $161 per person are available. Travel duration is 37h 5m
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Greyhound US47h 45m011:40 PMChicago95th Red Line Station11:25 PMSan Antonio, TXPearl District0EconomyA Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 12/13/2025 11:40:00 PM to Pearl District, San Antonio, TX (USA) arriving at 12/15/2025 11:25:00 PM. 50 Economy ticket for $161 per person are available. Travel duration is 47h 45m
Fastest Flights Saturday
Fastest Buses Saturday
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United Airlines3h 13m09:15 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center12:28 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/14/2025 9:15:00 AM to San Antonio Airport, San Antonio Airport (USA) arriving at 12/14/2025 12:28:00 PM. 50 Economy ticket for $466 per person are available. Travel duration is 3h 13m
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Skyscanner3h 17m01:20 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center4:37 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/14/2025 1:20:00 PM to San Antonio Airport, San Antonio Airport (USA) arriving at 12/14/2025 4:37:00 PM. 50 Economy ticket for $466 per person are available. Travel duration is 3h 17m
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Frontier Airlines6h 27m010:24 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center4:51 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from Frontier Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/14/2025 10:24:00 AM to San Antonio Airport, San Antonio Airport (USA) arriving at 12/14/2025 4:51:00 PM. 50 Economy ticket for $116 per person are available. Travel duration is 6h 27m
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Spirit Airlines6h 55m07:20 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center2:15 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from Spirit Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/14/2025 7:20:00 AM to San Antonio Airport, San Antonio Airport (USA) arriving at 12/14/2025 2:15:00 PM. 50 Economy ticket for $244 per person are available. Travel duration is 6h 55m
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Alaska Airlines24h 8m05:51 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center5:59 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from Alaska Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/14/2025 5:51:00 PM to San Antonio Airport, San Antonio Airport (USA) arriving at 12/15/2025 5:59:00 PM. 50 Economy ticket for $557 per person are available. Travel duration is 24h 8m
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Tornado Bus Company23h 45m01:30 PMChicagoCalifornia & 35th Street Bus Stop1:15 PMSan Antonio, TXTornado Bus Company0BasicA Bus from Tornado Bus Company goes from California & 35th Street Bus Stop, Chicago (USA) at 12/14/2025 1:30:00 PM to Tornado Bus Company, San Antonio, TX (USA) arriving at 12/15/2025 1:15:00 PM. 50 Basic ticket for $285 per person are available. Travel duration is 23h 45m
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FlixBus28h 30m07:25 PMChicago95th Red Line Station11:55 PMSan Antonio, TXBus Station0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 12/14/2025 7:25:00 PM to Bus Station, San Antonio, TX (USA) arriving at 12/15/2025 11:55:00 PM. 50 Economy ticket for $151 per person are available. Travel duration is 28h 30m
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FlixBus31h 10m05:45 AMChicago95th Red Line Station12:55 PMSan Antonio, TXBus Station0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 12/14/2025 5:45:00 AM to Bus Station, San Antonio, TX (USA) arriving at 12/15/2025 12:55:00 PM. 50 Economy ticket for $151 per person are available. Travel duration is 31h 10m
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Greyhound US47h 45m011:40 PMChicago95th Red Line Station11:25 PMSan Antonio, TXPearl District0EconomyA Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 12/14/2025 11:40:00 PM to Pearl District, San Antonio, TX (USA) arriving at 12/16/2025 11:25:00 PM. 50 Economy ticket for $154 per person are available. Travel duration is 47h 45m
Fastest Flights Sunday
Fastest Buses Sunday
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Greyhound US30h 45m06:10 AMChicagoDowntown Bus Station12:55 PMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/15/2025 6:10:00 AM to Bus Station, San Antonio, TX (USA) arriving at 12/16/2025 12:55:00 PM. 50 Economy ticket for $188 per person are available. Travel duration is 30h 45m
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Greyhound US31h 35m010:00 AMChicagoUnion Station5:35 PMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 12/15/2025 10:00:00 AM to Bus Station, San Antonio, TX (USA) arriving at 12/16/2025 5:35:00 PM. 50 Economy ticket for $188 per person are available. Travel duration is 31h 35m
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Greyhound US31h 55m09:40 AMChicagoDowntown Bus Station5:35 PMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/15/2025 9:40:00 AM to Bus Station, San Antonio, TX (USA) arriving at 12/16/2025 5:35:00 PM. 50 Economy ticket for $188 per person are available. Travel duration is 31h 55m
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Greyhound US40h 10m011:10 PMChicagoUnion Station3:20 PMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 12/15/2025 11:10:00 PM to Bus Station, San Antonio, TX (USA) arriving at 12/17/2025 3:20:00 PM. 50 Economy ticket for $188 per person are available. Travel duration is 40h 10m
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Greyhound US46h 40m010:30 PMChicagoDowntown Bus Station9:10 PMSan Antonio, TXPearl District0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/15/2025 10:30:00 PM to Pearl District, San Antonio, TX (USA) arriving at 12/17/2025 9:10:00 PM. 50 Economy ticket for $185 per person are available. Travel duration is 46h 40m
Fastest Buses Monday
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Greyhound US25h 25m010:30 PMChicagoDowntown Bus Station11:55 PMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/16/2025 10:30:00 PM to Bus Station, San Antonio, TX (USA) arriving at 12/17/2025 11:55:00 PM. 50 Economy ticket for $187 per person are available. Travel duration is 25h 25m
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Greyhound US30h 45m06:10 AMChicagoDowntown Bus Station12:55 PMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/16/2025 6:10:00 AM to Bus Station, San Antonio, TX (USA) arriving at 12/17/2025 12:55:00 PM. 50 Economy ticket for $212 per person are available. Travel duration is 30h 45m
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Greyhound US31h 35m010:00 AMChicagoUnion Station5:35 PMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 12/16/2025 10:00:00 AM to Bus Station, San Antonio, TX (USA) arriving at 12/17/2025 5:35:00 PM. 50 Economy ticket for $204 per person are available. Travel duration is 31h 35m
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Greyhound US31h 55m09:40 AMChicagoDowntown Bus Station5:35 PMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/16/2025 9:40:00 AM to Bus Station, San Antonio, TX (USA) arriving at 12/17/2025 5:35:00 PM. 50 Economy ticket for $204 per person are available. Travel duration is 31h 55m
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Greyhound US40h 10m011:10 PMChicagoUnion Station3:20 PMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 12/16/2025 11:10:00 PM to Bus Station, San Antonio, TX (USA) arriving at 12/18/2025 3:20:00 PM. 50 Economy ticket for $188 per person are available. Travel duration is 40h 10m
Fastest Buses Tuesday
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FlixBus27h 10m09:45 AMChicagoDowntown Bus Station12:55 PMSan Antonio, TXBus Station0EconomyA Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 12/18/2025 9:45:00 AM to Bus Station, San Antonio, TX (USA) arriving at 12/19/2025 12:55:00 PM. 50 Economy ticket for $235 per person are available. Travel duration is 27h 10m
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Greyhound US31h 35m010:00 AMChicagoUnion Station5:35 PMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 12/18/2025 10:00:00 AM to Bus Station, San Antonio, TX (USA) arriving at 12/19/2025 5:35:00 PM. 50 Economy ticket for $237 per person are available. Travel duration is 31h 35m
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FlixBus37h 40m09:45 AMChicagoDowntown Bus Station11:25 PMSan Antonio, TXPearl District0EconomyA Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 12/18/2025 9:45:00 AM to Pearl District, San Antonio, TX (USA) arriving at 12/19/2025 11:25:00 PM. 50 Economy ticket for $221 per person are available. Travel duration is 37h 40m
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Greyhound US48h 15m011:10 PMChicagoUnion Station11:25 PMSan Antonio, TXPearl District0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 12/18/2025 11:10:00 PM to Pearl District, San Antonio, TX (USA) arriving at 12/20/2025 11:25:00 PM. 50 Economy ticket for $217 per person are available. Travel duration is 48h 15m
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Greyhound US48h 35m010:50 PMChicagoDowntown Bus Station11:25 PMSan Antonio, TXPearl District0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/18/2025 10:50:00 PM to Pearl District, San Antonio, TX (USA) arriving at 12/20/2025 11:25:00 PM. 50 Economy ticket for $217 per person are available. Travel duration is 48h 35m
Fastest Buses Thursday
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Bus from Chicago to San Antonio, TX
What are the most popular stations in Chicago and San Antonio, TX?
In Chicago, you will usually depart from California & 35th Street Bus Stop, Downtown Bus Station or 95th Red Line Station, while in San Antonio, TX you will be arriving at Tornado Bus Company, Bus Station or W. Southcross & Buffalo Bus Stop, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to San Antonio, TX from Chicago? With 7 connections between 3 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Chicago and San Antonio, TX, you can pay as low as $116 with a Flight from Frontier Airlines.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from United Airlines: you will get to San Antonio, TX in just 3h 13m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Chicago and San Antonio, TX are Greyhound US, FlixBus and Tornado Bus Company, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Chicago and San Antonio, TX is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Cicero, IL or to Olmos Park, TX, and look at flights from Chicago Midway Airport, and landing at San Antonio Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Chicago to San Antonio, TX?
The most popular companies between Chicago and San Antonio, TX, are Greyhound US, FlixBus and Tornado Bus Company. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Greyhound US, FlixBus and Tornado Bus Company
Airlines: Frontier Airlines, Spirit Airlines, United Airlines and 2 more.
All you need to know when you travel from Chicago to San Antonio, TX
Check all information on comfort and services on all modes of transports from Chicago to San Antonio, TX. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Chicago to San Antonio, TX
How can I reach San Antonio, TX from Chicago?
Every day, there are on average 7 connections between Bus and Flight, with which you can get to San Antonio, TX from Chicago.
How far is San Antonio, TX from Chicago?
The distance between Chicago and San Antonio, TX is 1,052.2 miles.
What is the most ecofriendly mode of transport between Chicago and San Antonio, TX?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 46 kgs of CO2, a train 59 kgs, a car 288 kgs, and a flight 417 kgs.
What is the cheapest mode of transport from Chicago to San Antonio, TX?
You can get to San Antonio, TX with just $116 by taking a Flight from Frontier Airlines.
What is the fastest way to get from Chicago to San Antonio, TX?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to San Antonio, TX in just 3h 13m with a Flight from United Airlines.
More routes to Chicago and to San Antonio, TX
Looking for more options? Here you can see the most popular routes to Chicago and to San Antonio, TX. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Chicago
- Aguascalientes to Chicago
- Atlanta, GA to Chicago
- Buffalo, NY to Chicago
- Dallas to Chicago
- Durango, DG to Chicago
- El Paso, TX to Chicago
- Guadalajara, JC to Chicago
- Houston to Chicago
- Los Angeles to Chicago
- Louisville, KY to Chicago
- Memphis to Chicago
- Mexico City to Chicago
- Monterrey, NL to Chicago
- Nashville to Chicago
- New York to Chicago
- Pearson Toronto Airport to Chicago
- Philadelphia to Chicago
- Phoenix, AZ to Chicago
- San Antonio, TX to Chicago
- San Luis Potosí to Chicago
- Santiago de Queretaro to Chicago
- St. Louis, MO to Chicago
- Toronto, ON to Chicago
- Trips to San Antonio, TX
- Aguascalientes to San Antonio, TX
- Brownsville, TX to San Antonio, TX
- Ciudad Juárez to San Antonio, TX
- Dallas to San Antonio, TX
- Durango, DG to San Antonio, TX
- El Paso, TX to San Antonio, TX
- Guadalajara, JC to San Antonio, TX
- Houston to San Antonio, TX
- McAllen, TX to San Antonio, TX
- Memphis to San Antonio, TX
- Mexico City to San Antonio, TX
- Monterrey, NL to San Antonio, TX
- Orlando, FL to San Antonio, TX
- Phoenix, AZ to San Antonio, TX
- Reynosa to San Antonio, TX
- Saltillo to San Antonio, TX
- San Diego to San Antonio, TX
- San Luis Potosí to San Antonio, TX
- St. Louis, MO to San Antonio, TX
- Washington, DC to San Antonio, TX
- Zacatecas, ZS to San Antonio, TX

