What is the best way to travel from St. Louis, MO to San Antonio, TX?
Looking for a trip? Compare all the available Flights and Buses for the journey to San Antonio, TX from St. Louis, MO. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
What is the cheapest way to reach San Antonio, TX from St. Louis, MO?
You can get to San Antonio, TX with just $95 by taking a Bus from Greyhound US, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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FlixBus20h 55m04:00 PMSt. Louis, MOGateway Station12:55 PMSan Antonio, TXBus Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 6/25/2026 4:00:00 PM to Bus Station, San Antonio, TX (USA) arriving at 6/26/2026 12:55:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 20h 55m
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Greyhound US25h 30m011:45 PMSt. Louis, MOGateway Station1:15 AMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 6/25/2026 11:45:00 PM to Bus Station, San Antonio, TX (USA) arriving at 6/27/2026 1:15:00 AM. 50 Economy ticket for $108 per person are available. Travel duration is 25h 30m
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Greyhound US28h 40m04:30 PMSt. Louis, MOGateway Station9:10 PMSan Antonio, TXPearl District0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 6/25/2026 4:30:00 PM to Pearl District, San Antonio, TX (USA) arriving at 6/26/2026 9:10:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 28h 40m
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Greyhound US25h 40m04:30 PMSt. Louis, MOGateway Station6:10 PMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 6/25/2026 4:30:00 PM to Bus Station, San Antonio, TX (USA) arriving at 6/26/2026 6:10:00 PM. 50 Economy ticket for $109 per person are available. Travel duration is 25h 40m
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Frontier Airlines29h 15m02:56 PMSt. Louis Lambert AirportSt. Louis Lambert Airport8:11 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from Frontier Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 6/25/2026 2:56:00 PM to San Antonio Airport, San Antonio Airport (USA) arriving at 6/26/2026 8:11:00 PM. 50 Economy ticket for $164 per person are available. Travel duration is 29h 15m
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United Airlines6h 14m06:00 AMSt. Louis Lambert AirportSt. Louis Lambert Airport12:14 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from United Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 6/25/2026 6:00:00 AM to San Antonio Airport, San Antonio Airport (USA) arriving at 6/25/2026 12:14:00 PM. 50 Economy ticket for $240 per person are available. Travel duration is 6h 14m
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Skyscanner7h 3m06:14 AMSt. Louis Lambert AirportSt. Louis Lambert Airport1:17 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from Skyscanner goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 6/25/2026 6:14:00 AM to San Antonio Airport, San Antonio Airport (USA) arriving at 6/25/2026 1:17:00 PM. 50 Economy ticket for $240 per person are available. Travel duration is 7h 3m
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Allegiant Air25h 26m02:11 PMMidAmerica St. Louis AirportMidAmerica St. Louis Airport3:37 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from Allegiant Air goes from MidAmerica St. Louis Airport, MidAmerica St. Louis Airport (USA) at 6/25/2026 2:11:00 PM to San Antonio Airport, San Antonio Airport (USA) arriving at 6/26/2026 3:37:00 PM. 50 Economy ticket for $268 per person are available. Travel duration is 25h 26m
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Alaska Airlines22h 58m06:02 AMSt. Louis Lambert AirportSt. Louis Lambert Airport5:00 AMSan Antonio AirportSan Antonio Airport0EconomyA Flight from Alaska Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 6/25/2026 6:02:00 AM to San Antonio Airport, San Antonio Airport (USA) arriving at 6/26/2026 5:00:00 AM. 50 Economy ticket for $549 per person are available. Travel duration is 22h 58m
Cheapest Buses Thursday
Cheapest Flights Thursday
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Greyhound US22h 35m01:20 AMSt. Louis, MOGateway Station11:55 PMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 6/26/2026 1:20:00 AM to Bus Station, San Antonio, TX (USA) arriving at 6/26/2026 11:55:00 PM. 50 Economy ticket for $99 per person are available. Travel duration is 22h 35m
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Greyhound US28h 40m04:30 PMSt. Louis, MOGateway Station9:10 PMSan Antonio, TXPearl District0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 6/26/2026 4:30:00 PM to Pearl District, San Antonio, TX (USA) arriving at 6/27/2026 9:10:00 PM. 50 Economy ticket for $99 per person are available. Travel duration is 28h 40m
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Greyhound US25h 5m04:30 PMSt. Louis, MOGateway Station5:35 PMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 6/26/2026 4:30:00 PM to Bus Station, San Antonio, TX (USA) arriving at 6/27/2026 5:35:00 PM. 50 Economy ticket for $100 per person are available. Travel duration is 25h 5m
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FlixBus20h 55m04:00 PMSt. Louis, MOGateway Station12:55 PMSan Antonio, TXBus Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 6/26/2026 4:00:00 PM to Bus Station, San Antonio, TX (USA) arriving at 6/27/2026 12:55:00 PM. 50 Economy ticket for $100 per person are available. Travel duration is 20h 55m
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United Airlines9h 20m06:01 AMSt. Louis Lambert AirportSt. Louis Lambert Airport3:21 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from United Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 6/26/2026 6:01:00 AM to San Antonio Airport, San Antonio Airport (USA) arriving at 6/26/2026 3:21:00 PM. 50 Economy ticket for $283 per person are available. Travel duration is 9h 20m
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United Airlines4h 12m06:30 PMSt. Louis Lambert AirportSt. Louis Lambert Airport10:42 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from United Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 6/26/2026 6:30:00 PM to San Antonio Airport, San Antonio Airport (USA) arriving at 6/26/2026 10:42:00 PM. 50 Economy ticket for $310 per person are available. Travel duration is 4h 12m
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United Airlines6h 14m06:00 AMSt. Louis Lambert AirportSt. Louis Lambert Airport12:14 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from United Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 6/26/2026 6:00:00 AM to San Antonio Airport, San Antonio Airport (USA) arriving at 6/26/2026 12:14:00 PM. 50 Economy ticket for $321 per person are available. Travel duration is 6h 14m
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Frontier Airlines23h 18m07:38 PMSt. Louis Lambert AirportSt. Louis Lambert Airport6:56 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from Frontier Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 6/26/2026 7:38:00 PM to San Antonio Airport, San Antonio Airport (USA) arriving at 6/27/2026 6:56:00 PM. 50 Economy ticket for $337 per person are available. Travel duration is 23h 18m
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Frontier Airlines23h 20m04:17 PMSt. Louis Lambert AirportSt. Louis Lambert Airport3:37 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from Frontier Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 6/26/2026 4:17:00 PM to San Antonio Airport, San Antonio Airport (USA) arriving at 6/27/2026 3:37:00 PM. 50 Economy ticket for $383 per person are available. Travel duration is 23h 20m
Cheapest Buses Friday
Cheapest Flights Friday
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Greyhound US22h 35m01:20 AMSt. Louis, MOGateway Station11:55 PMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 6/27/2026 1:20:00 AM to Bus Station, San Antonio, TX (USA) arriving at 6/27/2026 11:55:00 PM. 50 Economy ticket for $104 per person are available. Travel duration is 22h 35m
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Greyhound US25h 40m04:30 PMSt. Louis, MOGateway Station6:10 PMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 6/27/2026 4:30:00 PM to Bus Station, San Antonio, TX (USA) arriving at 6/28/2026 6:10:00 PM. 50 Economy ticket for $105 per person are available. Travel duration is 25h 40m
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Greyhound US25h 30m011:45 PMSt. Louis, MOGateway Station1:15 AMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 6/27/2026 11:45:00 PM to Bus Station, San Antonio, TX (USA) arriving at 6/29/2026 1:15:00 AM. 50 Economy ticket for $105 per person are available. Travel duration is 25h 30m
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FlixBus20h 55m04:00 PMSt. Louis, MOGateway Station12:55 PMSan Antonio, TXBus Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 6/27/2026 4:00:00 PM to Bus Station, San Antonio, TX (USA) arriving at 6/28/2026 12:55:00 PM. 50 Economy ticket for $105 per person are available. Travel duration is 20h 55m
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United Airlines6h 14m06:00 AMSt. Louis Lambert AirportSt. Louis Lambert Airport12:14 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from United Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 6/27/2026 6:00:00 AM to San Antonio Airport, San Antonio Airport (USA) arriving at 6/27/2026 12:14:00 PM. 50 Economy ticket for $241 per person are available. Travel duration is 6h 14m
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United Airlines5h 24m05:33 PMSt. Louis Lambert AirportSt. Louis Lambert Airport10:57 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from United Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 6/27/2026 5:33:00 PM to San Antonio Airport, San Antonio Airport (USA) arriving at 6/27/2026 10:57:00 PM. 50 Economy ticket for $241 per person are available. Travel duration is 5h 24m
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Frontier Airlines23h 18m07:38 PMSt. Louis Lambert AirportSt. Louis Lambert Airport6:56 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from Frontier Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 6/27/2026 7:38:00 PM to San Antonio Airport, San Antonio Airport (USA) arriving at 6/28/2026 6:56:00 PM. 50 Economy ticket for $296 per person are available. Travel duration is 23h 18m
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Skyscanner4h 32m06:14 AMSt. Louis Lambert AirportSt. Louis Lambert Airport10:46 AMSan Antonio AirportSan Antonio Airport0EconomyA Flight from Skyscanner goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 6/27/2026 6:14:00 AM to San Antonio Airport, San Antonio Airport (USA) arriving at 6/27/2026 10:46:00 AM. 50 Economy ticket for $516 per person are available. Travel duration is 4h 32m
Cheapest Buses Saturday
Cheapest Flights Saturday
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Greyhound US25h 40m04:30 PMSt. Louis, MOGateway Station6:10 PMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 6/28/2026 4:30:00 PM to Bus Station, San Antonio, TX (USA) arriving at 6/29/2026 6:10:00 PM. 50 Economy ticket for $95 per person are available. Travel duration is 25h 40m
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Greyhound US25h 30m011:45 PMSt. Louis, MOGateway Station1:15 AMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 6/28/2026 11:45:00 PM to Bus Station, San Antonio, TX (USA) arriving at 6/30/2026 1:15:00 AM. 50 Economy ticket for $95 per person are available. Travel duration is 25h 30m
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FlixBus20h 55m04:00 PMSt. Louis, MOGateway Station12:55 PMSan Antonio, TXBus Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 6/28/2026 4:00:00 PM to Bus Station, San Antonio, TX (USA) arriving at 6/29/2026 12:55:00 PM. 50 Economy ticket for $95 per person are available. Travel duration is 20h 55m
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Greyhound US22h 35m01:20 AMSt. Louis, MOGateway Station11:55 PMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 6/28/2026 1:20:00 AM to Bus Station, San Antonio, TX (USA) arriving at 6/28/2026 11:55:00 PM. 50 Economy ticket for $96 per person are available. Travel duration is 22h 35m
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Frontier Airlines23h 18m07:38 PMSt. Louis Lambert AirportSt. Louis Lambert Airport6:56 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from Frontier Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 6/28/2026 7:38:00 PM to San Antonio Airport, San Antonio Airport (USA) arriving at 6/29/2026 6:56:00 PM. 50 Economy ticket for $327 per person are available. Travel duration is 23h 18m
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Frontier Airlines29h 15m02:56 PMSt. Louis Lambert AirportSt. Louis Lambert Airport8:11 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from Frontier Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 6/28/2026 2:56:00 PM to San Antonio Airport, San Antonio Airport (USA) arriving at 6/29/2026 8:11:00 PM. 50 Economy ticket for $367 per person are available. Travel duration is 29h 15m
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United Airlines7h 33m05:10 AMSt. Louis Lambert AirportSt. Louis Lambert Airport12:43 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from United Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 6/28/2026 5:10:00 AM to San Antonio Airport, San Antonio Airport (USA) arriving at 6/28/2026 12:43:00 PM. 50 Economy ticket for $535 per person are available. Travel duration is 7h 33m
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Alaska Airlines22h 58m06:02 AMSt. Louis Lambert AirportSt. Louis Lambert Airport5:00 AMSan Antonio AirportSan Antonio Airport0EconomyA Flight from Alaska Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 6/28/2026 6:02:00 AM to San Antonio Airport, San Antonio Airport (USA) arriving at 6/29/2026 5:00:00 AM. 50 Economy ticket for $547 per person are available. Travel duration is 22h 58m
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United Airlines5h 0m02:57 PMSt. Louis Lambert AirportSt. Louis Lambert Airport7:57 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from United Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 6/28/2026 2:57:00 PM to San Antonio Airport, San Antonio Airport (USA) arriving at 6/28/2026 7:57:00 PM. 50 Economy ticket for $598 per person are available. Travel duration is 5h 0m
Cheapest Buses Sunday
Cheapest Flights Sunday
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Greyhound US25h 30m011:45 PMSt. Louis, MOGateway Station1:15 AMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 6/29/2026 11:45:00 PM to Bus Station, San Antonio, TX (USA) arriving at 7/1/2026 1:15:00 AM. 50 Economy ticket for $97 per person are available. Travel duration is 25h 30m
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Greyhound US25h 40m04:30 PMSt. Louis, MOGateway Station6:10 PMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 6/29/2026 4:30:00 PM to Bus Station, San Antonio, TX (USA) arriving at 6/30/2026 6:10:00 PM. 50 Economy ticket for $98 per person are available. Travel duration is 25h 40m
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Greyhound US30h 55m04:30 PMSt. Louis, MOGateway Station11:25 PMSan Antonio, TXPearl District0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 6/29/2026 4:30:00 PM to Pearl District, San Antonio, TX (USA) arriving at 6/30/2026 11:25:00 PM. 50 Economy ticket for $98 per person are available. Travel duration is 30h 55m
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FlixBus20h 55m04:00 PMSt. Louis, MOGateway Station12:55 PMSan Antonio, TXBus Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 6/29/2026 4:00:00 PM to Bus Station, San Antonio, TX (USA) arriving at 6/30/2026 12:55:00 PM. 50 Economy ticket for $98 per person are available. Travel duration is 20h 55m
Cheapest Buses Monday
What are the fastest trips from St. Louis, MO to San Antonio, TX?
You can get to San Antonio, TX from St. Louis, MO in just 4h 12m with a Flight from United Airlines. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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United Airlines6h 14m06:00 AMSt. Louis Lambert AirportSt. Louis Lambert Airport12:14 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from United Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 6/25/2026 6:00:00 AM to San Antonio Airport, San Antonio Airport (USA) arriving at 6/25/2026 12:14:00 PM. 50 Economy ticket for $240 per person are available. Travel duration is 6h 14m
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Skyscanner7h 3m06:14 AMSt. Louis Lambert AirportSt. Louis Lambert Airport1:17 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from Skyscanner goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 6/25/2026 6:14:00 AM to San Antonio Airport, San Antonio Airport (USA) arriving at 6/25/2026 1:17:00 PM. 50 Economy ticket for $240 per person are available. Travel duration is 7h 3m
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Alaska Airlines22h 58m06:02 AMSt. Louis Lambert AirportSt. Louis Lambert Airport5:00 AMSan Antonio AirportSan Antonio Airport0EconomyA Flight from Alaska Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 6/25/2026 6:02:00 AM to San Antonio Airport, San Antonio Airport (USA) arriving at 6/26/2026 5:00:00 AM. 50 Economy ticket for $549 per person are available. Travel duration is 22h 58m
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Allegiant Air25h 26m02:11 PMMidAmerica St. Louis AirportMidAmerica St. Louis Airport3:37 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from Allegiant Air goes from MidAmerica St. Louis Airport, MidAmerica St. Louis Airport (USA) at 6/25/2026 2:11:00 PM to San Antonio Airport, San Antonio Airport (USA) arriving at 6/26/2026 3:37:00 PM. 50 Economy ticket for $268 per person are available. Travel duration is 25h 26m
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Frontier Airlines29h 15m02:56 PMSt. Louis Lambert AirportSt. Louis Lambert Airport8:11 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from Frontier Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 6/25/2026 2:56:00 PM to San Antonio Airport, San Antonio Airport (USA) arriving at 6/26/2026 8:11:00 PM. 50 Economy ticket for $164 per person are available. Travel duration is 29h 15m
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FlixBus20h 55m04:00 PMSt. Louis, MOGateway Station12:55 PMSan Antonio, TXBus Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 6/25/2026 4:00:00 PM to Bus Station, San Antonio, TX (USA) arriving at 6/26/2026 12:55:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 20h 55m
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Greyhound US25h 30m011:45 PMSt. Louis, MOGateway Station1:15 AMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 6/25/2026 11:45:00 PM to Bus Station, San Antonio, TX (USA) arriving at 6/27/2026 1:15:00 AM. 50 Economy ticket for $108 per person are available. Travel duration is 25h 30m
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Greyhound US25h 40m04:30 PMSt. Louis, MOGateway Station6:10 PMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 6/25/2026 4:30:00 PM to Bus Station, San Antonio, TX (USA) arriving at 6/26/2026 6:10:00 PM. 50 Economy ticket for $109 per person are available. Travel duration is 25h 40m
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Greyhound US28h 40m04:30 PMSt. Louis, MOGateway Station9:10 PMSan Antonio, TXPearl District0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 6/25/2026 4:30:00 PM to Pearl District, San Antonio, TX (USA) arriving at 6/26/2026 9:10:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 28h 40m
Fastest Flights Thursday
Fastest Buses Thursday
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United Airlines4h 12m06:30 PMSt. Louis Lambert AirportSt. Louis Lambert Airport10:42 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from United Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 6/26/2026 6:30:00 PM to San Antonio Airport, San Antonio Airport (USA) arriving at 6/26/2026 10:42:00 PM. 50 Economy ticket for $310 per person are available. Travel duration is 4h 12m
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United Airlines6h 14m06:00 AMSt. Louis Lambert AirportSt. Louis Lambert Airport12:14 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from United Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 6/26/2026 6:00:00 AM to San Antonio Airport, San Antonio Airport (USA) arriving at 6/26/2026 12:14:00 PM. 50 Economy ticket for $321 per person are available. Travel duration is 6h 14m
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United Airlines9h 20m06:01 AMSt. Louis Lambert AirportSt. Louis Lambert Airport3:21 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from United Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 6/26/2026 6:01:00 AM to San Antonio Airport, San Antonio Airport (USA) arriving at 6/26/2026 3:21:00 PM. 50 Economy ticket for $283 per person are available. Travel duration is 9h 20m
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Frontier Airlines23h 18m07:38 PMSt. Louis Lambert AirportSt. Louis Lambert Airport6:56 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from Frontier Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 6/26/2026 7:38:00 PM to San Antonio Airport, San Antonio Airport (USA) arriving at 6/27/2026 6:56:00 PM. 50 Economy ticket for $337 per person are available. Travel duration is 23h 18m
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Frontier Airlines23h 20m04:17 PMSt. Louis Lambert AirportSt. Louis Lambert Airport3:37 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from Frontier Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 6/26/2026 4:17:00 PM to San Antonio Airport, San Antonio Airport (USA) arriving at 6/27/2026 3:37:00 PM. 50 Economy ticket for $383 per person are available. Travel duration is 23h 20m
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FlixBus20h 55m04:00 PMSt. Louis, MOGateway Station12:55 PMSan Antonio, TXBus Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 6/26/2026 4:00:00 PM to Bus Station, San Antonio, TX (USA) arriving at 6/27/2026 12:55:00 PM. 50 Economy ticket for $100 per person are available. Travel duration is 20h 55m
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Greyhound US22h 35m01:20 AMSt. Louis, MOGateway Station11:55 PMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 6/26/2026 1:20:00 AM to Bus Station, San Antonio, TX (USA) arriving at 6/26/2026 11:55:00 PM. 50 Economy ticket for $99 per person are available. Travel duration is 22h 35m
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Greyhound US25h 5m04:30 PMSt. Louis, MOGateway Station5:35 PMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 6/26/2026 4:30:00 PM to Bus Station, San Antonio, TX (USA) arriving at 6/27/2026 5:35:00 PM. 50 Economy ticket for $100 per person are available. Travel duration is 25h 5m
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Greyhound US28h 40m04:30 PMSt. Louis, MOGateway Station9:10 PMSan Antonio, TXPearl District0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 6/26/2026 4:30:00 PM to Pearl District, San Antonio, TX (USA) arriving at 6/27/2026 9:10:00 PM. 50 Economy ticket for $99 per person are available. Travel duration is 28h 40m
Fastest Flights Friday
Fastest Buses Friday
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Skyscanner4h 32m06:14 AMSt. Louis Lambert AirportSt. Louis Lambert Airport10:46 AMSan Antonio AirportSan Antonio Airport0EconomyA Flight from Skyscanner goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 6/27/2026 6:14:00 AM to San Antonio Airport, San Antonio Airport (USA) arriving at 6/27/2026 10:46:00 AM. 50 Economy ticket for $516 per person are available. Travel duration is 4h 32m
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United Airlines5h 24m05:33 PMSt. Louis Lambert AirportSt. Louis Lambert Airport10:57 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from United Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 6/27/2026 5:33:00 PM to San Antonio Airport, San Antonio Airport (USA) arriving at 6/27/2026 10:57:00 PM. 50 Economy ticket for $241 per person are available. Travel duration is 5h 24m
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United Airlines6h 14m06:00 AMSt. Louis Lambert AirportSt. Louis Lambert Airport12:14 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from United Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 6/27/2026 6:00:00 AM to San Antonio Airport, San Antonio Airport (USA) arriving at 6/27/2026 12:14:00 PM. 50 Economy ticket for $241 per person are available. Travel duration is 6h 14m
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Frontier Airlines23h 18m07:38 PMSt. Louis Lambert AirportSt. Louis Lambert Airport6:56 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from Frontier Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 6/27/2026 7:38:00 PM to San Antonio Airport, San Antonio Airport (USA) arriving at 6/28/2026 6:56:00 PM. 50 Economy ticket for $296 per person are available. Travel duration is 23h 18m
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FlixBus20h 55m04:00 PMSt. Louis, MOGateway Station12:55 PMSan Antonio, TXBus Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 6/27/2026 4:00:00 PM to Bus Station, San Antonio, TX (USA) arriving at 6/28/2026 12:55:00 PM. 50 Economy ticket for $105 per person are available. Travel duration is 20h 55m
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Greyhound US22h 35m01:20 AMSt. Louis, MOGateway Station11:55 PMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 6/27/2026 1:20:00 AM to Bus Station, San Antonio, TX (USA) arriving at 6/27/2026 11:55:00 PM. 50 Economy ticket for $104 per person are available. Travel duration is 22h 35m
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Greyhound US25h 30m011:45 PMSt. Louis, MOGateway Station1:15 AMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 6/27/2026 11:45:00 PM to Bus Station, San Antonio, TX (USA) arriving at 6/29/2026 1:15:00 AM. 50 Economy ticket for $105 per person are available. Travel duration is 25h 30m
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Greyhound US25h 40m04:30 PMSt. Louis, MOGateway Station6:10 PMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 6/27/2026 4:30:00 PM to Bus Station, San Antonio, TX (USA) arriving at 6/28/2026 6:10:00 PM. 50 Economy ticket for $105 per person are available. Travel duration is 25h 40m
Fastest Flights Saturday
Fastest Buses Saturday
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United Airlines5h 0m02:57 PMSt. Louis Lambert AirportSt. Louis Lambert Airport7:57 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from United Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 6/28/2026 2:57:00 PM to San Antonio Airport, San Antonio Airport (USA) arriving at 6/28/2026 7:57:00 PM. 50 Economy ticket for $598 per person are available. Travel duration is 5h 0m
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United Airlines7h 33m05:10 AMSt. Louis Lambert AirportSt. Louis Lambert Airport12:43 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from United Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 6/28/2026 5:10:00 AM to San Antonio Airport, San Antonio Airport (USA) arriving at 6/28/2026 12:43:00 PM. 50 Economy ticket for $535 per person are available. Travel duration is 7h 33m
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Alaska Airlines22h 58m06:02 AMSt. Louis Lambert AirportSt. Louis Lambert Airport5:00 AMSan Antonio AirportSan Antonio Airport0EconomyA Flight from Alaska Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 6/28/2026 6:02:00 AM to San Antonio Airport, San Antonio Airport (USA) arriving at 6/29/2026 5:00:00 AM. 50 Economy ticket for $547 per person are available. Travel duration is 22h 58m
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Frontier Airlines23h 18m07:38 PMSt. Louis Lambert AirportSt. Louis Lambert Airport6:56 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from Frontier Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 6/28/2026 7:38:00 PM to San Antonio Airport, San Antonio Airport (USA) arriving at 6/29/2026 6:56:00 PM. 50 Economy ticket for $327 per person are available. Travel duration is 23h 18m
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Frontier Airlines29h 15m02:56 PMSt. Louis Lambert AirportSt. Louis Lambert Airport8:11 PMSan Antonio AirportSan Antonio Airport0EconomyA Flight from Frontier Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 6/28/2026 2:56:00 PM to San Antonio Airport, San Antonio Airport (USA) arriving at 6/29/2026 8:11:00 PM. 50 Economy ticket for $367 per person are available. Travel duration is 29h 15m
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FlixBus20h 55m04:00 PMSt. Louis, MOGateway Station12:55 PMSan Antonio, TXBus Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 6/28/2026 4:00:00 PM to Bus Station, San Antonio, TX (USA) arriving at 6/29/2026 12:55:00 PM. 50 Economy ticket for $95 per person are available. Travel duration is 20h 55m
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Greyhound US22h 35m01:20 AMSt. Louis, MOGateway Station11:55 PMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 6/28/2026 1:20:00 AM to Bus Station, San Antonio, TX (USA) arriving at 6/28/2026 11:55:00 PM. 50 Economy ticket for $96 per person are available. Travel duration is 22h 35m
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Greyhound US25h 30m011:45 PMSt. Louis, MOGateway Station1:15 AMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 6/28/2026 11:45:00 PM to Bus Station, San Antonio, TX (USA) arriving at 6/30/2026 1:15:00 AM. 50 Economy ticket for $95 per person are available. Travel duration is 25h 30m
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Greyhound US25h 40m04:30 PMSt. Louis, MOGateway Station6:10 PMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 6/28/2026 4:30:00 PM to Bus Station, San Antonio, TX (USA) arriving at 6/29/2026 6:10:00 PM. 50 Economy ticket for $95 per person are available. Travel duration is 25h 40m
Fastest Flights Sunday
Fastest Buses Sunday
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FlixBus20h 55m04:00 PMSt. Louis, MOGateway Station12:55 PMSan Antonio, TXBus Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 6/29/2026 4:00:00 PM to Bus Station, San Antonio, TX (USA) arriving at 6/30/2026 12:55:00 PM. 50 Economy ticket for $98 per person are available. Travel duration is 20h 55m
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Greyhound US25h 30m011:45 PMSt. Louis, MOGateway Station1:15 AMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 6/29/2026 11:45:00 PM to Bus Station, San Antonio, TX (USA) arriving at 7/1/2026 1:15:00 AM. 50 Economy ticket for $97 per person are available. Travel duration is 25h 30m
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Greyhound US25h 40m04:30 PMSt. Louis, MOGateway Station6:10 PMSan Antonio, TXBus Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 6/29/2026 4:30:00 PM to Bus Station, San Antonio, TX (USA) arriving at 6/30/2026 6:10:00 PM. 50 Economy ticket for $98 per person are available. Travel duration is 25h 40m
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Greyhound US30h 55m04:30 PMSt. Louis, MOGateway Station11:25 PMSan Antonio, TXPearl District0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 6/29/2026 4:30:00 PM to Pearl District, San Antonio, TX (USA) arriving at 6/30/2026 11:25:00 PM. 50 Economy ticket for $98 per person are available. Travel duration is 30h 55m
Fastest Buses Monday
Here you will find all operators and timetables for a
Bus from St. Louis, MO to San Antonio, TX
What are the most popular stations in St. Louis, MO and San Antonio, TX?
In St. Louis, MO, you will usually depart from Gateway Station, Lindbergh @ Hackberry NB Bus Stop or Skinker Boulevard, while in San Antonio, TX you will be arriving at Tornado Bus Company, Bus Station or W. Southcross & Buffalo Bus Stop, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to San Antonio, TX from St. Louis, MO? With 8 connections between 2 Flight and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between St. Louis, MO and San Antonio, TX, you can pay as low as $95 with a Bus from Greyhound US.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from United Airlines: you will get to San Antonio, TX in just 4h 12m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting St. Louis, MO and San Antonio, TX are Greyhound US, FlixBus and United Airlines, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in St. Louis, MO and San Antonio, TX is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Sauget, IL or to Olmos Park, TX, and look at flights from St. Louis Lambert Airport, and landing at San Antonio Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from St. Louis, MO to San Antonio, TX?
The most popular companies between St. Louis, MO and San Antonio, TX, are Greyhound US, FlixBus and United Airlines. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Greyhound US and FlixBus
Airlines: United Airlines, Frontier Airlines, Skyscanner and 2 more.
All you need to know when you travel from St. Louis, MO to San Antonio, TX
Check all information on comfort and services on all modes of transports from St. Louis, MO to San Antonio, TX. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from St. Louis, MO to San Antonio, TX
How can I reach San Antonio, TX from St. Louis, MO?
Every day, there are on average 8 connections between Flight and Bus, with which you can get to San Antonio, TX from St. Louis, MO.
How far is San Antonio, TX from St. Louis, MO?
The distance between St. Louis, MO and San Antonio, TX is 792.3 miles.
What is the most ecofriendly mode of transport between St. Louis, MO and San Antonio, TX?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 34 kgs of CO2, a train 45 kgs, a car 217 kgs, and a flight 314 kgs.
What is the cheapest mode of transport from St. Louis, MO to San Antonio, TX?
You can get to San Antonio, TX with just $95 by taking a Bus from Greyhound US.
What is the fastest way to get from St. Louis, MO to San Antonio, TX?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to San Antonio, TX in just 4h 12m with a Flight from United Airlines.
More routes to St. Louis, MO and to San Antonio, TX
Looking for more options? Here you can see the most popular routes to St. Louis, MO and to San Antonio, TX. Simply click on a connection, and you’ll find all the details about the route!
