Bus St. Louis, MO to San Antonio, TX: Compare prices and save money

Compare all timetables for the bus from St. Louis, MO to San Antonio, TX

Here is a selection of the cheapest bus trips from the schedule from St. Louis, MO to San Antonio, TX from various bus operators like Greyhound US or FlixBus for the next days.

today

$127

tomorrow

$130

Wednesday

Thursday

$145

Friday

$170

Saturday

Sunday

$175

Cheapest bus trips today
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	20h 55m	4:00 PM	St. Louis, MO	Gateway Station	12:55 PM	San Antonio, TX	Bus Station		Economy	$127	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/15/2025 4:00:00 PM to Bus Station, San Antonio, TX (USA) arriving at 12/16/2025 12:55:00 PM. 50 Economy ticket for $127 per person are available. Travel duration is 20h 55m
	Greyhound US	25h 5m	4:30 PM	St. Louis, MO	Gateway Station	5:35 PM	San Antonio, TX	Bus Station		Economy	$127	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/15/2025 4:30:00 PM to Bus Station, San Antonio, TX (USA) arriving at 12/16/2025 5:35:00 PM. 50 Economy ticket for $127 per person are available. Travel duration is 25h 5m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	22h 30m	1:20 AM	St. Louis, MO	Gateway Station	11:50 PM	San Antonio, TX	Bus Station	Economy	$130	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/16/2025 1:20:00 AM to Bus Station, San Antonio, TX (USA) arriving at 12/16/2025 11:50:00 PM. 50 Economy ticket for $130 per person are available. Travel duration is 22h 30m
Greyhound US	23h 45m	1:30 AM	St. Louis, MO	Gateway Station	1:15 AM	San Antonio, TX	Bus Station	Economy	$130	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/16/2025 1:30:00 AM to Bus Station, San Antonio, TX (USA) arriving at 12/17/2025 1:15:00 AM. 50 Economy ticket for $130 per person are available. Travel duration is 23h 45m
Greyhound US	25h 5m	4:30 PM	St. Louis, MO	Gateway Station	5:35 PM	San Antonio, TX	Bus Station	Economy	$131	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/16/2025 4:30:00 PM to Bus Station, San Antonio, TX (USA) arriving at 12/17/2025 5:35:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 25h 5m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	25h 5m	4:30 PM	St. Louis, MO	Gateway Station	5:35 PM	San Antonio, TX	Bus Station	Economy	$145	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/18/2025 4:30:00 PM to Bus Station, San Antonio, TX (USA) arriving at 12/19/2025 5:35:00 PM. 50 Economy ticket for $145 per person are available. Travel duration is 25h 5m
Greyhound US	30h 55m	4:30 PM	St. Louis, MO	Gateway Station	11:25 PM	San Antonio, TX	Pearl District	Economy	$145	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/18/2025 4:30:00 PM to Pearl District, San Antonio, TX (USA) arriving at 12/19/2025 11:25:00 PM. 50 Economy ticket for $145 per person are available. Travel duration is 30h 55m
Greyhound US	23h 45m	1:30 AM	St. Louis, MO	Gateway Station	1:15 AM	San Antonio, TX	Bus Station	Economy	$146	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/18/2025 1:30:00 AM to Bus Station, San Antonio, TX (USA) arriving at 12/19/2025 1:15:00 AM. 50 Economy ticket for $146 per person are available. Travel duration is 23h 45m
FlixBus	20h 55m	4:00 PM	St. Louis, MO	Gateway Station	12:55 PM	San Antonio, TX	Bus Station	Economy	$157	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/18/2025 4:00:00 PM to Bus Station, San Antonio, TX (USA) arriving at 12/19/2025 12:55:00 PM. 50 Economy ticket for $157 per person are available. Travel duration is 20h 55m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	30h 55m	4:30 PM	St. Louis, MO	Gateway Station	11:25 PM	San Antonio, TX	Pearl District	Economy	$170	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/19/2025 4:30:00 PM to Pearl District, San Antonio, TX (USA) arriving at 12/20/2025 11:25:00 PM. 50 Economy ticket for $170 per person are available. Travel duration is 30h 55m
Greyhound US	25h 5m	4:30 PM	St. Louis, MO	Gateway Station	5:35 PM	San Antonio, TX	Bus Station	Economy	$171	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/19/2025 4:30:00 PM to Bus Station, San Antonio, TX (USA) arriving at 12/20/2025 5:35:00 PM. 50 Economy ticket for $171 per person are available. Travel duration is 25h 5m
Greyhound US	22h 30m	1:20 AM	St. Louis, MO	Gateway Station	11:50 PM	San Antonio, TX	Bus Station	Economy	$173	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/19/2025 1:20:00 AM to Bus Station, San Antonio, TX (USA) arriving at 12/19/2025 11:50:00 PM. 50 Economy ticket for $173 per person are available. Travel duration is 22h 30m
FlixBus	20h 55m	4:00 PM	St. Louis, MO	Gateway Station	12:55 PM	San Antonio, TX	Bus Station	Economy	$197	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/19/2025 4:00:00 PM to Bus Station, San Antonio, TX (USA) arriving at 12/20/2025 12:55:00 PM. 50 Economy ticket for $197 per person are available. Travel duration is 20h 55m

Did you know that if you travel from St. Louis, MO to San Antonio, TX via Austin, you can save more than $33? You can find the corresponding connections below.
- FlixBus
  
  23h 45m
  
  0
  
  1:30 AM
  
  St. Louis, MO
  Gateway Station
  
  11:35 PM
  
  Austin
  5119 Eastside Bus Plaza
  
  0
  
  Economy
  
  $124
  
  A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/16/2025 1:30:00 AM to 5119 Eastside Bus Plaza, Austin (USA) arriving at 12/16/2025 11:35:00 PM. 50 Economy ticket for $124 per person are available. Travel duration is 22h 5m
- Busbud
  
  1h 30m
  
  0
  
  11:45 PM
  
  Austin
  5119 Eastside Bus Plaza
  
  1:15 AM
  
  San Antonio, TX
  Bus Station
  
  0
  
  Economy
  
  $13
  
  A Bus from Busbud goes from 5119 Eastside Bus Plaza, Austin (USA) at 12/16/2025 11:45:00 PM to Bus Station, San Antonio, TX (USA) arriving at 12/17/2025 1:15:00 AM. 50 Economy ticket for $13 per person are available. Travel duration is 1h 30m
Travel time is 2h 50m longer, but you will save $33

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	23h 45m	1:30 AM	St. Louis, MO	Gateway Station	1:15 AM	San Antonio, TX	Bus Station	Economy	$175	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/21/2025 1:30:00 AM to Bus Station, San Antonio, TX (USA) arriving at 12/22/2025 1:15:00 AM. 50 Economy ticket for $175 per person are available. Travel duration is 23h 45m
Greyhound US	25h 5m	4:30 PM	St. Louis, MO	Gateway Station	5:35 PM	San Antonio, TX	Bus Station	Economy	$176	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/21/2025 4:30:00 PM to Bus Station, San Antonio, TX (USA) arriving at 12/22/2025 5:35:00 PM. 50 Economy ticket for $176 per person are available. Travel duration is 25h 5m
Greyhound US	30h 55m	4:30 PM	St. Louis, MO	Gateway Station	11:25 PM	San Antonio, TX	Pearl District	Economy	$176	A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/21/2025 4:30:00 PM to Pearl District, San Antonio, TX (USA) arriving at 12/22/2025 11:25:00 PM. 50 Economy ticket for $176 per person are available. Travel duration is 30h 55m
FlixBus	20h 55m	4:00 PM	St. Louis, MO	Gateway Station	12:55 PM	San Antonio, TX	Bus Station	Economy	$244	A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/21/2025 4:00:00 PM to Bus Station, San Antonio, TX (USA) arriving at 12/22/2025 12:55:00 PM. 50 Economy ticket for $244 per person are available. Travel duration is 20h 55m

Did you know that if you travel from St. Louis, MO to San Antonio, TX via Austin, you can save more than $38? You can find the corresponding connections below.
- FlixBus
  
  23h 45m
  
  0
  
  1:30 AM
  
  St. Louis, MO
  Gateway Station
  
  11:35 PM
  
  Austin
  5119 Eastside Bus Plaza
  
  0
  
  Economy
  
  $124
  
  A Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/16/2025 1:30:00 AM to 5119 Eastside Bus Plaza, Austin (USA) arriving at 12/16/2025 11:35:00 PM. 50 Economy ticket for $124 per person are available. Travel duration is 22h 5m
- Busbud
  
  1h 30m
  
  0
  
  11:45 PM
  
  Austin
  5119 Eastside Bus Plaza
  
  1:15 AM
  
  San Antonio, TX
  Bus Station
  
  0
  
  Economy
  
  $13
  
  A Bus from Busbud goes from 5119 Eastside Bus Plaza, Austin (USA) at 12/16/2025 11:45:00 PM to Bus Station, San Antonio, TX (USA) arriving at 12/17/2025 1:15:00 AM. 50 Economy ticket for $13 per person are available. Travel duration is 1h 30m
Travel time is 2h 50m longer, but you will save $38

Best Price Offer: The price for the cheapest bus from St. Louis, MO to San Antonio, TX is $116 on 1/9/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between St. Louis, MO and San Antonio, TX

See here how frequent the connections between St. Louis, MO and San Antonio, TX are, during different times and days of the week.

Friday is the busiest day, with more than 10 daily buses from St. Louis, MO to San Antonio, TX. Monday has instead the fewest connections, with only 4 daily coaches between St. Louis, MO and San Antonio, TX.

The busiest time of the day is the Afternoon, with 18 buses from St. Louis, MO to San Antonio, TX, while Night sees the fewest connections between St. Louis, MO and San Antonio, TX, with 12 offers.

Facts about the bus from St. Louis, MO to San Antonio, TX

Compare all providers like Greyhound US and FlixBus that travel 6 times every day by bus from St. Louis, MO to San Antonio, TX in one click! Book your bus ticket from St. Louis, MO to San Antonio, TX starting from $116!

Cheapest Bus	$116
Fastest Bus	20h 55m
Earliest Bus	4:00 PM
Latest Bus	4:30 PM
Daily Bus Routes	6 Ø
Distance	792.3 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from St. Louis, MO to San Antonio, TX

Every day, 6 buses from 2 bus companies leave St. Louis, MO for San Antonio, TX: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/15/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 12/14

Monday 12/15

$128

Tuesday 12/16

$131

Wednesday 12/17

Thursday 12/18

$145

Friday 12/19

$170

Saturday 12/20

Sunday 12/21

$175

Monday 12/22

Tuesday 12/23

Wednesday 12/24

Thursday 12/25

Friday 12/26

Saturday 12/27

Sunday 12/28

Monday 12/29

$155

Tuesday 12/30

$151

Wednesday 12/31

Thursday 01/01

$135

Friday 01/02

Saturday 01/03

Sunday 01/04

Monday 01/05

Tuesday 01/06

Wednesday 01/07

Thursday 01/08

Friday 01/09

$116

Saturday 01/10

The cheapest time to travel from St. Louis, MO to San Antonio, TX

See here on which day and which time of the day you can find the cheapest bus ticket from St. Louis, MO to San Antonio, TX, for the next 30 days.

With a price starting from $116, Friday is the cheapest day for a bus from St. Louis, MO to San Antonio, TX. Sunday instead is the most expensive day with prices starting from $175.

Night is the cheapest day time for bus tickets from St. Louis, MO to San Antonio, TX, with $116. Afternoon is the most expensive time of the day with prices starting from $127.

How to save money travelling from St. Louis, MO to San Antonio, TX

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from St. Louis, MO to San Antonio, TX in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from St. Louis, MO to San Antonio, TX, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from St. Louis, MO to San Antonio, TX are also emptier.

Beloved bus companies from St. Louis, MO to San Antonio, TX

These are the most booked bus companies between St. Louis, MO to San Antonio, TX from our users.

FlixBus from St. Louis, MO to San Antonio, TX

Here you will find the key facts about the FlixBus bus route St. Louis, MO to San Antonio, TX:

Cheapest Price	$127
Fastest Bus	20h 55m
Earliest Bus	4:00 PM
Last Bus	4:00 PM
Daily Connections	1 Ø
Found on	12/13/2025

Greyhound US from St. Louis, MO to San Antonio, TX

Here you will find the key facts about the Greyhound US bus route St. Louis, MO to San Antonio, TX:

Cheapest Price	$127
Fastest Bus	22h 30m
Earliest Bus	4:30 PM
Last Bus	4:30 PM
Daily Connections	4 Ø
Found on	12/13/2025

All bus stations and stops in St. Louis, MO and San Antonio, TX

In the map below, you can see where to find all bus stations in St. Louis, MO and San Antonio, TX.

Gateway Station

S 15th St 430

Skinker Boulevard

Boulevard between Lindell Blvd. and Lagoon Drive

Lindbergh @ Hackberry NB Bus Stop

Bus Station

N St Mary's St 500

San Antonio

Pearl District

Avenue A 699-599

W. Southcross & Buffalo Bus Stop

Commerce & Bowie Bus Stop

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from St. Louis, MO to San Antonio, TX? Compare all modes of transports from St. Louis, MO to San Antonio, TX.

Service and Comfort on the bus from St. Louis, MO to San Antonio, TX

Want to know which seat classes are available on the buses from St. Louis, MO to San Antonio, TX? Or which bus companies serve the route St. Louis, MO to San Antonio, TX? Below you will find answers to your questions.

FAQs about the St. Louis, MO to San Antonio, TX bus

How much does a St. Louis, MO San Antonio, TX bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $116 and takes 20h 55m to reach San Antonio, TX. Compare offers to save money!

How much could I save by comparing buses from St. Louis, MO to San Antonio, TX?

This route is offered by 2 companies with a range of ticket prices between $116 and $244. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to San Antonio, TX.

On average, how many connections are available from St. Louis, MO to San Antonio, TX each day?

Every day, the St. Louis, MO to San Antonio, TX bus route is served by approximately 6 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from St. Louis, MO to San Antonio, TX take?

The fastest bus from St. Louis, MO to San Antonio, TX is offered by FlixBus and takes 20h 55m. Bus tickets for this connection cost $127. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from St. Louis, MO to San Antonio, TX?

The earliest bus arriving in San Antonio, TX from St. Louis, MO starts at 4:00 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from St. Louis, MO to San Antonio, TX?

The latest bus trip departing from St. Louis, MO for San Antonio, TX starts at 4:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the St. Louis, MO San Antonio, TX route?

When traveling by bus from St. Louis, MO to San Antonio, TX, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between St. Louis, MO and San Antonio, TX?

You can check all the direct connections between St. Louis, MO and San Antonio, TX by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the St. Louis, MO to San Antonio, TX bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the St. Louis, MO San Antonio, TX bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the St. Louis, MO San Antonio, TX bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from St. Louis, MO to San Antonio, TX on your planned travel date.

How does CheckMyBus find the best bus deals from St. Louis, MO to San Antonio, TX?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 6 daily trips between St. Louis, MO and San Antonio, TX. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from St. Louis, MO to San Antonio, TX?

Prices and availability for 6 trips between St. Louis, MO and San Antonio, TX change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route St. Louis, MO to San Antonio, TX

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to St. Louis, MO and to San Antonio, TX

Here’s an overview of the most popular bus routes to St. Louis, MO and to San Antonio, TX. Simply click on the connection of your choice, and you will find all the details about your bus route!