How to get from Detroit to St. Louis, MO

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What is the best way to travel from Detroit to St. Louis, MO?

Looking for a trip? Compare all the available Flights and Buses for the journey to St. Louis, MO from Detroit. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 1 available companies to find your perfect trip!
Flight is the cheapest and fastest way on this route
Transport type
Travel time
Cheapest price
Average price
Daily departures
Bus
12h 40m
$65
$76
8
Flight
4h 21m
$62
$208
66

What is the cheapest way to reach St. Louis, MO from Detroit?

You can get to St. Louis, MO with just $62 by taking a Flight from Frontier Airlines, but you can find many more cheap offers: we have selected the best ones for next few days here for you.

Tuesday
from $65
Wednesday
from $62
Thursday
from $63
Friday
from $74
Saturday
from $82
Sunday
from $83
Monday
from $76

    Cheapest Buses Tuesday

  • Greyhound US
    15h 55m
    0
    8:20 AM
    Detroit
    Central Bus Station
    11:15 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $65
  • Greyhound US
    17h 25m
    0
    11:15 PM
    Detroit
    Central Bus Station
    3:40 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $65
  • Greyhound US
    15h 5m
    0
    4:20 PM
    Detroit
    Central Bus Station
    6:25 AM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $66
  • Greyhound US
    12h 40m
    0
    8:15 PM
    Detroit
    Central Bus Station
    7:55 AM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $66
  • Cheapest Flights Tuesday

  • Frontier Airlines
    7h 3m
    0
    1:20 PM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    7:23 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Frontier Airlines
    Economy
    from $89
  • Frontier Airlines
    11h 43m
    0
    6:50 AM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    5:33 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Frontier Airlines
    Economy
    from $92
  • United Airlines
    6h 6m
    0
    7:05 AM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    12:11 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    United Airlines
    Economy
    from $100
  • United Airlines
    4h 21m
    0
    8:50 AM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    12:11 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    United Airlines
    Economy
    from $104
  • Skyscanner
    5h 39m
    0
    6:00 AM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    10:39 AM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Skyscanner
    Economy
    from $267

    Cheapest Flights Wednesday

  • Frontier Airlines
    24h 28m
    0
    6:05 PM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    5:33 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Frontier Airlines
    Economy
    from $62
  • United Airlines
    6h 6m
    0
    7:05 AM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    12:11 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    United Airlines
    Economy
    from $136
  • United Airlines
    4h 21m
    0
    8:50 AM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    12:11 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    United Airlines
    Economy
    from $140
  • Frontier Airlines
    12h 13m
    0
    12:44 PM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    11:57 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Frontier Airlines
    Economy
    from $169
  • Frontier Airlines
    25h 37m
    0
    12:44 PM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    1:21 PM
    MidAmerica St. Louis Airport
    MidAmerica St. Louis Airport
    0
    Frontier Airlines
    Economy
    from $230
  • Alaska Airlines
    12h 36m
    0
    7:09 AM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    6:45 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Alaska Airlines
    Economy
    from $376
  • Cheapest Buses Wednesday

  • Greyhound US
    17h 0m
    0
    7:15 AM
    Detroit
    Central Bus Station
    11:15 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $75
  • Greyhound US
    15h 5m
    0
    4:20 PM
    Detroit
    Central Bus Station
    6:25 AM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $75
  • Greyhound US
    12h 40m
    0
    8:15 PM
    Detroit
    Central Bus Station
    7:55 AM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $75
  • Greyhound US
    17h 25m
    0
    11:15 PM
    Detroit
    Central Bus Station
    3:40 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $75

    Cheapest Flights Thursday

  • Frontier Airlines
    11h 43m
    0
    6:50 AM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    5:33 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Frontier Airlines
    Economy
    from $63
  • Frontier Airlines
    27h 5m
    0
    6:50 AM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    8:55 AM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Frontier Airlines
    Economy
    from $63
  • United Airlines
    6h 6m
    0
    7:05 AM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    12:11 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    United Airlines
    Economy
    from $135
  • United Airlines
    4h 21m
    0
    8:50 AM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    12:11 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    United Airlines
    Economy
    from $140
  • Alaska Airlines
    12h 36m
    0
    7:09 AM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    6:45 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Alaska Airlines
    Economy
    from $400
  • Cheapest Buses Thursday

  • Greyhound US
    17h 25m
    0
    11:15 PM
    Detroit
    Central Bus Station
    3:40 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $73
  • Greyhound US
    17h 0m
    0
    7:15 AM
    Detroit
    Central Bus Station
    11:15 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $74
  • Greyhound US
    12h 40m
    0
    8:15 PM
    Detroit
    Central Bus Station
    7:55 AM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $74
  • Greyhound US
    15h 5m
    0
    4:20 PM
    Detroit
    Central Bus Station
    6:25 AM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $75

    Cheapest Buses Friday

  • Greyhound US
    16h 0m
    0
    8:20 AM
    Detroit
    Central Bus Station
    11:20 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $74
  • Greyhound US
    15h 5m
    0
    4:20 PM
    Detroit
    Central Bus Station
    6:25 AM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $74
  • Greyhound US
    12h 40m
    0
    8:15 PM
    Detroit
    Central Bus Station
    7:55 AM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $75
  • Greyhound US
    17h 25m
    0
    11:15 PM
    Detroit
    Central Bus Station
    3:40 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $75
  • Greyhound US
    15h 55m
    0
    8:20 AM
    Detroit
    Central Bus Station
    11:15 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $80
  • Cheapest Flights Friday

  • Skyscanner
    5h 4m
    0
    4:05 PM
    Windsor International Airport
    Windsor International Airport
    8:09 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Skyscanner
    Economy
    from $482
  • Skyscanner
    11h 4m
    0
    10:05 AM
    Windsor International Airport
    Windsor International Airport
    8:09 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Skyscanner
    Economy
    from $609

    Cheapest Buses Saturday

  • Greyhound US
    15h 55m
    0
    8:20 AM
    Detroit
    Central Bus Station
    11:15 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $82
  • Greyhound US
    15h 5m
    0
    4:20 PM
    Detroit
    Central Bus Station
    6:25 AM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $83
  • Greyhound US
    12h 40m
    0
    8:15 PM
    Detroit
    Central Bus Station
    7:55 AM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $83
  • Greyhound US
    17h 25m
    0
    11:15 PM
    Detroit
    Central Bus Station
    3:40 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $83
  • Cheapest Flights Saturday

  • United Airlines
    6h 6m
    0
    7:05 AM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    12:11 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    United Airlines
    Economy
    from $100
  • Frontier Airlines
    7h 3m
    0
    1:20 PM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    7:23 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Frontier Airlines
    Economy
    from $107
  • Frontier Airlines
    12h 28m
    0
    7:55 AM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    7:23 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Frontier Airlines
    Economy
    from $129
  • Skyscanner
    4h 28m
    0
    10:55 AM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    2:23 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Skyscanner
    Economy
    from $269
  • Frontier Airlines
    25h 37m
    0
    12:44 PM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    1:21 PM
    MidAmerica St. Louis Airport
    MidAmerica St. Louis Airport
    0
    Frontier Airlines
    Economy
    from $511

    Cheapest Buses Sunday

  • Greyhound US
    15h 5m
    0
    4:20 PM
    Detroit
    Central Bus Station
    6:25 AM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $83
  • Greyhound US
    17h 25m
    0
    11:15 PM
    Detroit
    Central Bus Station
    3:40 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $83
  • Greyhound US
    15h 55m
    0
    8:20 AM
    Detroit
    Central Bus Station
    11:15 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $84
  • Greyhound US
    12h 40m
    0
    8:15 PM
    Detroit
    Central Bus Station
    7:55 AM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $84
  • Cheapest Flights Sunday

  • Frontier Airlines
    11h 43m
    0
    6:50 AM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    5:33 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Frontier Airlines
    Economy
    from $154
  • Frontier Airlines
    19h 56m
    0
    1:59 PM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    8:55 AM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Frontier Airlines
    Economy
    from $154
  • United Airlines
    6h 6m
    0
    7:05 AM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    12:11 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    United Airlines
    Economy
    from $189
  • United Airlines
    4h 21m
    0
    8:50 AM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    12:11 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    United Airlines
    Economy
    from $193
  • Skyscanner
    4h 42m
    0
    7:47 PM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    11:29 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Skyscanner
    Economy
    from $203
  • Frontier Airlines
    20h 24m
    0
    6:57 PM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    2:21 PM
    MidAmerica St. Louis Airport
    MidAmerica St. Louis Airport
    0
    Frontier Airlines
    Economy
    from $383

    Cheapest Buses Monday

  • Greyhound US
    15h 5m
    0
    4:20 PM
    Detroit
    Central Bus Station
    6:25 AM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $76
  • Greyhound US
    15h 55m
    0
    8:20 AM
    Detroit
    Central Bus Station
    11:15 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $77
  • Greyhound US
    12h 40m
    0
    8:15 PM
    Detroit
    Central Bus Station
    7:55 AM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $77
  • Greyhound US
    17h 25m
    0
    11:15 PM
    Detroit
    Central Bus Station
    3:40 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $77
  • Cheapest Flights Monday

  • United Airlines
    5h 46m
    0
    11:00 AM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    3:46 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    United Airlines
    Economy
    from $126
  • Frontier Airlines
    24h 25m
    0
    6:05 PM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    5:30 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Frontier Airlines
    Economy
    from $143
  • Skyscanner
    4h 42m
    0
    7:47 PM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    11:29 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Skyscanner
    Economy
    from $176

What are the fastest trips from Detroit to St. Louis, MO?

You can get to St. Louis, MO from Detroit in just 4h 21m with a Flight from United Airlines. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.

Tuesday
from 4h 21m
Wednesday
from 4h 21m
Thursday
from 4h 21m
Friday
from 5h 4m
Saturday
from 4h 28m
Sunday
from 4h 21m
Monday
from 4h 42m

    Fastest Flights Tuesday

  • United Airlines
    4h 21m
    0
    8:50 AM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    12:11 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    United Airlines
    Economy
    from $104
  • Skyscanner
    5h 39m
    0
    6:00 AM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    10:39 AM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Skyscanner
    Economy
    from $267
  • United Airlines
    6h 6m
    0
    7:05 AM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    12:11 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    United Airlines
    Economy
    from $100
  • Frontier Airlines
    7h 3m
    0
    1:20 PM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    7:23 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Frontier Airlines
    Economy
    from $89
  • Frontier Airlines
    11h 43m
    0
    6:50 AM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    5:33 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Frontier Airlines
    Economy
    from $92
  • Fastest Buses Tuesday

  • Greyhound US
    12h 40m
    0
    8:15 PM
    Detroit
    Central Bus Station
    7:55 AM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $66
  • Greyhound US
    15h 5m
    0
    4:20 PM
    Detroit
    Central Bus Station
    6:25 AM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $66
  • Greyhound US
    15h 55m
    0
    8:20 AM
    Detroit
    Central Bus Station
    11:15 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $65
  • Greyhound US
    17h 25m
    0
    11:15 PM
    Detroit
    Central Bus Station
    3:40 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $65

    Fastest Flights Wednesday

  • United Airlines
    4h 21m
    0
    8:50 AM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    12:11 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    United Airlines
    Economy
    from $140
  • United Airlines
    6h 6m
    0
    7:05 AM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    12:11 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    United Airlines
    Economy
    from $136
  • Frontier Airlines
    12h 13m
    0
    12:44 PM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    11:57 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Frontier Airlines
    Economy
    from $169
  • Alaska Airlines
    12h 36m
    0
    7:09 AM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    6:45 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Alaska Airlines
    Economy
    from $376
  • Frontier Airlines
    24h 28m
    0
    6:05 PM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    5:33 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Frontier Airlines
    Economy
    from $62
  • Frontier Airlines
    25h 37m
    0
    12:44 PM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    1:21 PM
    MidAmerica St. Louis Airport
    MidAmerica St. Louis Airport
    0
    Frontier Airlines
    Economy
    from $230
  • Fastest Buses Wednesday

  • Greyhound US
    12h 40m
    0
    8:15 PM
    Detroit
    Central Bus Station
    7:55 AM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $75
  • Greyhound US
    15h 5m
    0
    4:20 PM
    Detroit
    Central Bus Station
    6:25 AM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $75
  • Greyhound US
    17h 0m
    0
    7:15 AM
    Detroit
    Central Bus Station
    11:15 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $75
  • Greyhound US
    17h 25m
    0
    11:15 PM
    Detroit
    Central Bus Station
    3:40 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $75

    Fastest Flights Thursday

  • United Airlines
    4h 21m
    0
    8:50 AM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    12:11 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    United Airlines
    Economy
    from $140
  • United Airlines
    6h 6m
    0
    7:05 AM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    12:11 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    United Airlines
    Economy
    from $135
  • Frontier Airlines
    11h 43m
    0
    6:50 AM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    5:33 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Frontier Airlines
    Economy
    from $63
  • Alaska Airlines
    12h 36m
    0
    7:09 AM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    6:45 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Alaska Airlines
    Economy
    from $400
  • Frontier Airlines
    27h 5m
    0
    6:50 AM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    8:55 AM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Frontier Airlines
    Economy
    from $63
  • Fastest Buses Thursday

  • Greyhound US
    12h 40m
    0
    8:15 PM
    Detroit
    Central Bus Station
    7:55 AM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $74
  • Greyhound US
    15h 5m
    0
    4:20 PM
    Detroit
    Central Bus Station
    6:25 AM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $75
  • Greyhound US
    17h 0m
    0
    7:15 AM
    Detroit
    Central Bus Station
    11:15 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $74
  • Greyhound US
    17h 25m
    0
    11:15 PM
    Detroit
    Central Bus Station
    3:40 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $73

    Fastest Flights Friday

  • Skyscanner
    5h 4m
    0
    4:05 PM
    Windsor International Airport
    Windsor International Airport
    8:09 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Skyscanner
    Economy
    from $482
  • Skyscanner
    11h 4m
    0
    10:05 AM
    Windsor International Airport
    Windsor International Airport
    8:09 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Skyscanner
    Economy
    from $609
  • Fastest Buses Friday

  • Greyhound US
    12h 40m
    0
    8:15 PM
    Detroit
    Central Bus Station
    7:55 AM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $75
  • Greyhound US
    15h 5m
    0
    4:20 PM
    Detroit
    Central Bus Station
    6:25 AM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $74
  • Greyhound US
    15h 55m
    0
    8:20 AM
    Detroit
    Central Bus Station
    11:15 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $80
  • Greyhound US
    16h 0m
    0
    8:20 AM
    Detroit
    Central Bus Station
    11:20 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $74
  • Greyhound US
    17h 25m
    0
    11:15 PM
    Detroit
    Central Bus Station
    3:40 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $75

    Fastest Flights Saturday

  • Skyscanner
    4h 28m
    0
    10:55 AM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    2:23 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Skyscanner
    Economy
    from $269
  • United Airlines
    6h 6m
    0
    7:05 AM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    12:11 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    United Airlines
    Economy
    from $100
  • Frontier Airlines
    7h 3m
    0
    1:20 PM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    7:23 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Frontier Airlines
    Economy
    from $107
  • Frontier Airlines
    12h 28m
    0
    7:55 AM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    7:23 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Frontier Airlines
    Economy
    from $129
  • Frontier Airlines
    25h 37m
    0
    12:44 PM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    1:21 PM
    MidAmerica St. Louis Airport
    MidAmerica St. Louis Airport
    0
    Frontier Airlines
    Economy
    from $511
  • Fastest Buses Saturday

  • Greyhound US
    12h 40m
    0
    8:15 PM
    Detroit
    Central Bus Station
    7:55 AM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $83
  • Greyhound US
    15h 5m
    0
    4:20 PM
    Detroit
    Central Bus Station
    6:25 AM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $83
  • Greyhound US
    15h 55m
    0
    8:20 AM
    Detroit
    Central Bus Station
    11:15 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $82
  • Greyhound US
    17h 25m
    0
    11:15 PM
    Detroit
    Central Bus Station
    3:40 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $83

    Fastest Flights Sunday

  • United Airlines
    4h 21m
    0
    8:50 AM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    12:11 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    United Airlines
    Economy
    from $193
  • Skyscanner
    4h 42m
    0
    7:47 PM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    11:29 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Skyscanner
    Economy
    from $203
  • United Airlines
    6h 6m
    0
    7:05 AM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    12:11 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    United Airlines
    Economy
    from $189
  • Frontier Airlines
    11h 43m
    0
    6:50 AM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    5:33 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Frontier Airlines
    Economy
    from $154
  • Frontier Airlines
    19h 56m
    0
    1:59 PM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    8:55 AM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Frontier Airlines
    Economy
    from $154
  • Frontier Airlines
    20h 3m
    0
    12:44 PM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    7:47 AM
    MidAmerica St. Louis Airport
    MidAmerica St. Louis Airport
    0
    Frontier Airlines
    Economy
    from $385
  • Fastest Buses Sunday

  • Greyhound US
    12h 40m
    0
    8:15 PM
    Detroit
    Central Bus Station
    7:55 AM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $84
  • Greyhound US
    15h 5m
    0
    4:20 PM
    Detroit
    Central Bus Station
    6:25 AM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $83
  • Greyhound US
    15h 55m
    0
    8:20 AM
    Detroit
    Central Bus Station
    11:15 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $84
  • Greyhound US
    17h 25m
    0
    11:15 PM
    Detroit
    Central Bus Station
    3:40 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $83

    Fastest Flights Monday

  • Skyscanner
    4h 42m
    0
    7:47 PM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    11:29 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Skyscanner
    Economy
    from $176
  • United Airlines
    5h 46m
    0
    11:00 AM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    3:46 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    United Airlines
    Economy
    from $126
  • Frontier Airlines
    24h 25m
    0
    6:05 PM
    Detroit Metropolitan Wayne County Airport
    Detroit Metropolitan Wayne County Airport
    5:30 PM
    St. Louis Lambert Airport
    St. Louis Lambert Airport
    0
    Frontier Airlines
    Economy
    from $143
  • Fastest Buses Monday

  • Greyhound US
    12h 40m
    0
    8:15 PM
    Detroit
    Central Bus Station
    7:55 AM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $77
  • Greyhound US
    15h 5m
    0
    4:20 PM
    Detroit
    Central Bus Station
    6:25 AM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $76
  • Greyhound US
    15h 55m
    0
    8:20 AM
    Detroit
    Central Bus Station
    11:15 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $77
  • Greyhound US
    17h 25m
    0
    11:15 PM
    Detroit
    Central Bus Station
    3:40 PM
    St. Louis, MO
    Gateway Station
    0
    Greyhound US
    Economy
    $77
Here you will find all operators and timetables for a Bus from Detroit to St. Louis, MO

What are the most popular stations in Detroit and St. Louis, MO?

In Detroit, you will usually depart from Central Bus Station, Amtrak or Park Avenue, while in St. Louis, MO you will be arriving at Gateway Station, Lindbergh @ Hackberry NB Bus Stop or Skinker Boulevard, but there are many more stops to explore in both locations.

How do I decide? Some tips and tricks from our experience

Are you having trouble deciding on how to get to St. Louis, MO from Detroit? With 9 connections between 1 Flight and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.

Look for the lowest price

Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Detroit and St. Louis, MO, you can pay as low as $62 with a Flight from Frontier Airlines.

Travel duration

Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from United Airlines: you will get to St. Louis, MO in just 4h 21m.

Comfort makes all the difference

You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Detroit and St. Louis, MO are Greyhound US, Frontier Airlines and United Airlines, but be sure to check what they have to offer!

Save money with deals, and always compare

One last tip? Even if you live in Detroit and St. Louis, MO is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Windsor, ON or to Sauget, IL, and look at flights from Detroit Metropolitan Wayne County Airport, and landing at St. Louis Lambert Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!

Which companies offer a trip from Detroit to St. Louis, MO?

The most popular companies between Detroit and St. Louis, MO, are Greyhound US, Frontier Airlines and United Airlines. Be sure to check their seat class offers and the amenities that they provide.

Bus companies: Greyhound US

Airlines: Frontier Airlines, United Airlines, Skyscanner and 1 more.

All you need to know when you travel from Detroit to St. Louis, MO

Check all information on comfort and services on all modes of transports from Detroit to St. Louis, MO. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.

FAQs about the trip from Detroit to St. Louis, MO

How can I reach St. Louis, MO from Detroit?

Every day, there are on average 9 connections between Flight and Bus, with which you can get to St. Louis, MO from Detroit.

How far is St. Louis, MO from Detroit?

The distance between Detroit and St. Louis, MO is 454.7 miles.

What is the most ecofriendly mode of transport between Detroit and St. Louis, MO?

Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance. On this particular route, a bus will emit, per person, a total of 20 kgs of CO2, a train 26 kgs, a car 124 kgs, and a flight 180 kgs.

What is the cheapest mode of transport from Detroit to St. Louis, MO?

You can get to St. Louis, MO with just $62 by taking a Flight from Frontier Airlines.

What is the fastest way to get from Detroit to St. Louis, MO?

While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to St. Louis, MO in just 4h 21m with a Flight from United Airlines.

More routes to Detroit and to St. Louis, MO

Looking for more options? Here you can see the most popular routes to Detroit and to St. Louis, MO. Simply click on a connection, and you’ll find all the details about the route!

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