What is the best way to travel from Detroit to St. Louis, MO?
Looking for a trip? Compare all the available Flights and Buses for the journey to St. Louis, MO from Detroit. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 1 available companies to find your perfect trip!
What is the cheapest way to reach St. Louis, MO from Detroit?
You can get to St. Louis, MO with just $62 by taking a Flight from Frontier Airlines, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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Greyhound US15h 55m08:20 AMDetroitCentral Bus Station11:15 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/2/2026 8:20:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/2/2026 11:15:00 PM. 50 Economy ticket for $65 per person are available. Travel duration is 15h 55m
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Greyhound US17h 25m011:15 PMDetroitCentral Bus Station3:40 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/2/2026 11:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/3/2026 3:40:00 PM. 50 Economy ticket for $65 per person are available. Travel duration is 17h 25m
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Greyhound US15h 5m04:20 PMDetroitCentral Bus Station6:25 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/2/2026 4:20:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/3/2026 6:25:00 AM. 50 Economy ticket for $66 per person are available. Travel duration is 15h 5m
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Greyhound US12h 40m08:15 PMDetroitCentral Bus Station7:55 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/2/2026 8:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/3/2026 7:55:00 AM. 50 Economy ticket for $66 per person are available. Travel duration is 12h 40m
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Frontier Airlines7h 3m01:20 PMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport7:23 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/2/2026 1:20:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/2/2026 7:23:00 PM. 50 Economy ticket for $89 per person are available. Travel duration is 7h 3m
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Frontier Airlines11h 43m06:50 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport5:33 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/2/2026 6:50:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/2/2026 5:33:00 PM. 50 Economy ticket for $92 per person are available. Travel duration is 11h 43m
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United Airlines6h 6m07:05 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport12:11 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/2/2026 7:05:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/2/2026 12:11:00 PM. 50 Economy ticket for $100 per person are available. Travel duration is 6h 6m
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United Airlines4h 21m08:50 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport12:11 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/2/2026 8:50:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/2/2026 12:11:00 PM. 50 Economy ticket for $104 per person are available. Travel duration is 4h 21m
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Skyscanner5h 39m06:00 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport10:39 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/2/2026 6:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/2/2026 10:39:00 AM. 50 Economy ticket for $267 per person are available. Travel duration is 5h 39m
Cheapest Buses Tuesday
Cheapest Flights Tuesday
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Frontier Airlines24h 28m06:05 PMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport5:33 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/3/2026 6:05:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/4/2026 5:33:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 24h 28m
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United Airlines6h 6m07:05 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport12:11 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/3/2026 7:05:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/3/2026 12:11:00 PM. 50 Economy ticket for $136 per person are available. Travel duration is 6h 6m
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United Airlines4h 21m08:50 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport12:11 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/3/2026 8:50:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/3/2026 12:11:00 PM. 50 Economy ticket for $140 per person are available. Travel duration is 4h 21m
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Frontier Airlines12h 13m012:44 PMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport11:57 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/3/2026 12:44:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/3/2026 11:57:00 PM. 50 Economy ticket for $169 per person are available. Travel duration is 12h 13m
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Frontier Airlines25h 37m012:44 PMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport1:21 PMMidAmerica St. Louis AirportMidAmerica St. Louis Airport0EconomyA Flight from Frontier Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/3/2026 12:44:00 PM to MidAmerica St. Louis Airport, MidAmerica St. Louis Airport (USA) arriving at 6/4/2026 1:21:00 PM. 50 Economy ticket for $230 per person are available. Travel duration is 25h 37m
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Alaska Airlines12h 36m07:09 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport6:45 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Alaska Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/3/2026 7:09:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/3/2026 6:45:00 PM. 50 Economy ticket for $376 per person are available. Travel duration is 12h 36m
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Greyhound US17h 0m07:15 AMDetroitCentral Bus Station11:15 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/3/2026 7:15:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/3/2026 11:15:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 17h 0m
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Greyhound US15h 5m04:20 PMDetroitCentral Bus Station6:25 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/3/2026 4:20:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/4/2026 6:25:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 15h 5m
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Greyhound US12h 40m08:15 PMDetroitCentral Bus Station7:55 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/3/2026 8:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/4/2026 7:55:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 12h 40m
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Greyhound US17h 25m011:15 PMDetroitCentral Bus Station3:40 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/3/2026 11:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/4/2026 3:40:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 17h 25m
Cheapest Flights Wednesday
Cheapest Buses Wednesday
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Frontier Airlines11h 43m06:50 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport5:33 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/4/2026 6:50:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/4/2026 5:33:00 PM. 50 Economy ticket for $63 per person are available. Travel duration is 11h 43m
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Frontier Airlines27h 5m06:50 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport8:55 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/4/2026 6:50:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/5/2026 8:55:00 AM. 50 Economy ticket for $63 per person are available. Travel duration is 27h 5m
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United Airlines6h 6m07:05 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport12:11 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/4/2026 7:05:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/4/2026 12:11:00 PM. 50 Economy ticket for $135 per person are available. Travel duration is 6h 6m
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United Airlines4h 21m08:50 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport12:11 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/4/2026 8:50:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/4/2026 12:11:00 PM. 50 Economy ticket for $140 per person are available. Travel duration is 4h 21m
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Alaska Airlines12h 36m07:09 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport6:45 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Alaska Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/4/2026 7:09:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/4/2026 6:45:00 PM. 50 Economy ticket for $400 per person are available. Travel duration is 12h 36m
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Greyhound US17h 25m011:15 PMDetroitCentral Bus Station3:40 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/4/2026 11:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/5/2026 3:40:00 PM. 50 Economy ticket for $73 per person are available. Travel duration is 17h 25m
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Greyhound US17h 0m07:15 AMDetroitCentral Bus Station11:15 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/4/2026 7:15:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/4/2026 11:15:00 PM. 50 Economy ticket for $74 per person are available. Travel duration is 17h 0m
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Greyhound US12h 40m08:15 PMDetroitCentral Bus Station7:55 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/4/2026 8:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/5/2026 7:55:00 AM. 50 Economy ticket for $74 per person are available. Travel duration is 12h 40m
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Greyhound US15h 5m04:20 PMDetroitCentral Bus Station6:25 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/4/2026 4:20:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/5/2026 6:25:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 15h 5m
Cheapest Flights Thursday
Cheapest Buses Thursday
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Greyhound US16h 0m08:20 AMDetroitCentral Bus Station11:20 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/5/2026 8:20:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/5/2026 11:20:00 PM. 50 Economy ticket for $74 per person are available. Travel duration is 16h 0m
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Greyhound US15h 5m04:20 PMDetroitCentral Bus Station6:25 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/5/2026 4:20:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/6/2026 6:25:00 AM. 50 Economy ticket for $74 per person are available. Travel duration is 15h 5m
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Greyhound US12h 40m08:15 PMDetroitCentral Bus Station7:55 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/5/2026 8:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/6/2026 7:55:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 12h 40m
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Greyhound US17h 25m011:15 PMDetroitCentral Bus Station3:40 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/5/2026 11:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/6/2026 3:40:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 17h 25m
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Greyhound US15h 55m08:20 AMDetroitCentral Bus Station11:15 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/5/2026 8:20:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/5/2026 11:15:00 PM. 50 Economy ticket for $80 per person are available. Travel duration is 15h 55m
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Skyscanner5h 4m04:05 PMWindsor International AirportWindsor International Airport8:09 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Windsor International Airport, Windsor International Airport (Canada) at 6/5/2026 4:05:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/5/2026 8:09:00 PM. 50 Economy ticket for $482 per person are available. Travel duration is 5h 4m
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Skyscanner11h 4m010:05 AMWindsor International AirportWindsor International Airport8:09 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Windsor International Airport, Windsor International Airport (Canada) at 6/5/2026 10:05:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/5/2026 8:09:00 PM. 50 Economy ticket for $609 per person are available. Travel duration is 11h 4m
Cheapest Buses Friday
Cheapest Flights Friday
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Greyhound US15h 55m08:20 AMDetroitCentral Bus Station11:15 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/6/2026 8:20:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/6/2026 11:15:00 PM. 50 Economy ticket for $82 per person are available. Travel duration is 15h 55m
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Greyhound US15h 5m04:20 PMDetroitCentral Bus Station6:25 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/6/2026 4:20:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/7/2026 6:25:00 AM. 50 Economy ticket for $83 per person are available. Travel duration is 15h 5m
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Greyhound US12h 40m08:15 PMDetroitCentral Bus Station7:55 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/6/2026 8:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/7/2026 7:55:00 AM. 50 Economy ticket for $83 per person are available. Travel duration is 12h 40m
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Greyhound US17h 25m011:15 PMDetroitCentral Bus Station3:40 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/6/2026 11:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/7/2026 3:40:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 17h 25m
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United Airlines6h 6m07:05 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport12:11 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/6/2026 7:05:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/6/2026 12:11:00 PM. 50 Economy ticket for $100 per person are available. Travel duration is 6h 6m
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Frontier Airlines7h 3m01:20 PMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport7:23 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/6/2026 1:20:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/6/2026 7:23:00 PM. 50 Economy ticket for $107 per person are available. Travel duration is 7h 3m
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Frontier Airlines12h 28m07:55 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport7:23 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/6/2026 7:55:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/6/2026 7:23:00 PM. 50 Economy ticket for $129 per person are available. Travel duration is 12h 28m
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Skyscanner4h 28m010:55 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport2:23 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/6/2026 10:55:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/6/2026 2:23:00 PM. 50 Economy ticket for $269 per person are available. Travel duration is 4h 28m
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Frontier Airlines25h 37m012:44 PMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport1:21 PMMidAmerica St. Louis AirportMidAmerica St. Louis Airport0EconomyA Flight from Frontier Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/6/2026 12:44:00 PM to MidAmerica St. Louis Airport, MidAmerica St. Louis Airport (USA) arriving at 6/7/2026 1:21:00 PM. 50 Economy ticket for $511 per person are available. Travel duration is 25h 37m
Cheapest Buses Saturday
Cheapest Flights Saturday
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Greyhound US15h 5m04:20 PMDetroitCentral Bus Station6:25 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/7/2026 4:20:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/8/2026 6:25:00 AM. 50 Economy ticket for $83 per person are available. Travel duration is 15h 5m
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Greyhound US17h 25m011:15 PMDetroitCentral Bus Station3:40 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/7/2026 11:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/8/2026 3:40:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 17h 25m
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Greyhound US15h 55m08:20 AMDetroitCentral Bus Station11:15 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/7/2026 8:20:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/7/2026 11:15:00 PM. 50 Economy ticket for $84 per person are available. Travel duration is 15h 55m
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Greyhound US12h 40m08:15 PMDetroitCentral Bus Station7:55 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/7/2026 8:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/8/2026 7:55:00 AM. 50 Economy ticket for $84 per person are available. Travel duration is 12h 40m
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Frontier Airlines11h 43m06:50 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport5:33 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/7/2026 6:50:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/7/2026 5:33:00 PM. 50 Economy ticket for $154 per person are available. Travel duration is 11h 43m
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Frontier Airlines19h 56m01:59 PMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport8:55 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/7/2026 1:59:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/8/2026 8:55:00 AM. 50 Economy ticket for $154 per person are available. Travel duration is 19h 56m
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United Airlines6h 6m07:05 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport12:11 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/7/2026 7:05:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/7/2026 12:11:00 PM. 50 Economy ticket for $189 per person are available. Travel duration is 6h 6m
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United Airlines4h 21m08:50 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport12:11 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/7/2026 8:50:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/7/2026 12:11:00 PM. 50 Economy ticket for $193 per person are available. Travel duration is 4h 21m
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Skyscanner4h 42m07:47 PMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport11:29 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/7/2026 7:47:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/7/2026 11:29:00 PM. 50 Economy ticket for $203 per person are available. Travel duration is 4h 42m
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Frontier Airlines20h 24m06:57 PMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport2:21 PMMidAmerica St. Louis AirportMidAmerica St. Louis Airport0EconomyA Flight from Frontier Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/7/2026 6:57:00 PM to MidAmerica St. Louis Airport, MidAmerica St. Louis Airport (USA) arriving at 6/8/2026 2:21:00 PM. 50 Economy ticket for $383 per person are available. Travel duration is 20h 24m
Cheapest Buses Sunday
Cheapest Flights Sunday
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Greyhound US15h 5m04:20 PMDetroitCentral Bus Station6:25 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/8/2026 4:20:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/9/2026 6:25:00 AM. 50 Economy ticket for $76 per person are available. Travel duration is 15h 5m
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Greyhound US15h 55m08:20 AMDetroitCentral Bus Station11:15 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/8/2026 8:20:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/8/2026 11:15:00 PM. 50 Economy ticket for $77 per person are available. Travel duration is 15h 55m
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Greyhound US12h 40m08:15 PMDetroitCentral Bus Station7:55 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/8/2026 8:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/9/2026 7:55:00 AM. 50 Economy ticket for $77 per person are available. Travel duration is 12h 40m
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Greyhound US17h 25m011:15 PMDetroitCentral Bus Station3:40 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/8/2026 11:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/9/2026 3:40:00 PM. 50 Economy ticket for $77 per person are available. Travel duration is 17h 25m
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United Airlines5h 46m011:00 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport3:46 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/8/2026 11:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/8/2026 3:46:00 PM. 50 Economy ticket for $126 per person are available. Travel duration is 5h 46m
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Frontier Airlines24h 25m06:05 PMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport5:30 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/8/2026 6:05:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/9/2026 5:30:00 PM. 50 Economy ticket for $143 per person are available. Travel duration is 24h 25m
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Skyscanner4h 42m07:47 PMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport11:29 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/8/2026 7:47:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/8/2026 11:29:00 PM. 50 Economy ticket for $176 per person are available. Travel duration is 4h 42m
Cheapest Buses Monday
Cheapest Flights Monday
What are the fastest trips from Detroit to St. Louis, MO?
You can get to St. Louis, MO from Detroit in just 4h 21m with a Flight from United Airlines. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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United Airlines4h 21m08:50 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport12:11 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/2/2026 8:50:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/2/2026 12:11:00 PM. 50 Economy ticket for $104 per person are available. Travel duration is 4h 21m
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Skyscanner5h 39m06:00 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport10:39 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/2/2026 6:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/2/2026 10:39:00 AM. 50 Economy ticket for $267 per person are available. Travel duration is 5h 39m
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United Airlines6h 6m07:05 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport12:11 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/2/2026 7:05:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/2/2026 12:11:00 PM. 50 Economy ticket for $100 per person are available. Travel duration is 6h 6m
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Frontier Airlines7h 3m01:20 PMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport7:23 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/2/2026 1:20:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/2/2026 7:23:00 PM. 50 Economy ticket for $89 per person are available. Travel duration is 7h 3m
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Frontier Airlines11h 43m06:50 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport5:33 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/2/2026 6:50:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/2/2026 5:33:00 PM. 50 Economy ticket for $92 per person are available. Travel duration is 11h 43m
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Greyhound US12h 40m08:15 PMDetroitCentral Bus Station7:55 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/2/2026 8:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/3/2026 7:55:00 AM. 50 Economy ticket for $66 per person are available. Travel duration is 12h 40m
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Greyhound US15h 5m04:20 PMDetroitCentral Bus Station6:25 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/2/2026 4:20:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/3/2026 6:25:00 AM. 50 Economy ticket for $66 per person are available. Travel duration is 15h 5m
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Greyhound US15h 55m08:20 AMDetroitCentral Bus Station11:15 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/2/2026 8:20:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/2/2026 11:15:00 PM. 50 Economy ticket for $65 per person are available. Travel duration is 15h 55m
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Greyhound US17h 25m011:15 PMDetroitCentral Bus Station3:40 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/2/2026 11:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/3/2026 3:40:00 PM. 50 Economy ticket for $65 per person are available. Travel duration is 17h 25m
Fastest Flights Tuesday
Fastest Buses Tuesday
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United Airlines4h 21m08:50 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport12:11 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/3/2026 8:50:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/3/2026 12:11:00 PM. 50 Economy ticket for $140 per person are available. Travel duration is 4h 21m
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United Airlines6h 6m07:05 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport12:11 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/3/2026 7:05:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/3/2026 12:11:00 PM. 50 Economy ticket for $136 per person are available. Travel duration is 6h 6m
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Frontier Airlines12h 13m012:44 PMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport11:57 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/3/2026 12:44:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/3/2026 11:57:00 PM. 50 Economy ticket for $169 per person are available. Travel duration is 12h 13m
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Alaska Airlines12h 36m07:09 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport6:45 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Alaska Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/3/2026 7:09:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/3/2026 6:45:00 PM. 50 Economy ticket for $376 per person are available. Travel duration is 12h 36m
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Frontier Airlines24h 28m06:05 PMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport5:33 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/3/2026 6:05:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/4/2026 5:33:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 24h 28m
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Frontier Airlines25h 37m012:44 PMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport1:21 PMMidAmerica St. Louis AirportMidAmerica St. Louis Airport0EconomyA Flight from Frontier Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/3/2026 12:44:00 PM to MidAmerica St. Louis Airport, MidAmerica St. Louis Airport (USA) arriving at 6/4/2026 1:21:00 PM. 50 Economy ticket for $230 per person are available. Travel duration is 25h 37m
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Greyhound US12h 40m08:15 PMDetroitCentral Bus Station7:55 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/3/2026 8:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/4/2026 7:55:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 12h 40m
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Greyhound US15h 5m04:20 PMDetroitCentral Bus Station6:25 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/3/2026 4:20:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/4/2026 6:25:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 15h 5m
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Greyhound US17h 0m07:15 AMDetroitCentral Bus Station11:15 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/3/2026 7:15:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/3/2026 11:15:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 17h 0m
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Greyhound US17h 25m011:15 PMDetroitCentral Bus Station3:40 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/3/2026 11:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/4/2026 3:40:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 17h 25m
Fastest Flights Wednesday
Fastest Buses Wednesday
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United Airlines4h 21m08:50 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport12:11 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/4/2026 8:50:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/4/2026 12:11:00 PM. 50 Economy ticket for $140 per person are available. Travel duration is 4h 21m
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United Airlines6h 6m07:05 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport12:11 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/4/2026 7:05:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/4/2026 12:11:00 PM. 50 Economy ticket for $135 per person are available. Travel duration is 6h 6m
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Frontier Airlines11h 43m06:50 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport5:33 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/4/2026 6:50:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/4/2026 5:33:00 PM. 50 Economy ticket for $63 per person are available. Travel duration is 11h 43m
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Alaska Airlines12h 36m07:09 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport6:45 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Alaska Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/4/2026 7:09:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/4/2026 6:45:00 PM. 50 Economy ticket for $400 per person are available. Travel duration is 12h 36m
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Frontier Airlines27h 5m06:50 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport8:55 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/4/2026 6:50:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/5/2026 8:55:00 AM. 50 Economy ticket for $63 per person are available. Travel duration is 27h 5m
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Greyhound US12h 40m08:15 PMDetroitCentral Bus Station7:55 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/4/2026 8:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/5/2026 7:55:00 AM. 50 Economy ticket for $74 per person are available. Travel duration is 12h 40m
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Greyhound US15h 5m04:20 PMDetroitCentral Bus Station6:25 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/4/2026 4:20:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/5/2026 6:25:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 15h 5m
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Greyhound US17h 0m07:15 AMDetroitCentral Bus Station11:15 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/4/2026 7:15:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/4/2026 11:15:00 PM. 50 Economy ticket for $74 per person are available. Travel duration is 17h 0m
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Greyhound US17h 25m011:15 PMDetroitCentral Bus Station3:40 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/4/2026 11:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/5/2026 3:40:00 PM. 50 Economy ticket for $73 per person are available. Travel duration is 17h 25m
Fastest Flights Thursday
Fastest Buses Thursday
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Skyscanner5h 4m04:05 PMWindsor International AirportWindsor International Airport8:09 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Windsor International Airport, Windsor International Airport (Canada) at 6/5/2026 4:05:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/5/2026 8:09:00 PM. 50 Economy ticket for $482 per person are available. Travel duration is 5h 4m
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Skyscanner11h 4m010:05 AMWindsor International AirportWindsor International Airport8:09 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Windsor International Airport, Windsor International Airport (Canada) at 6/5/2026 10:05:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/5/2026 8:09:00 PM. 50 Economy ticket for $609 per person are available. Travel duration is 11h 4m
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Greyhound US12h 40m08:15 PMDetroitCentral Bus Station7:55 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/5/2026 8:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/6/2026 7:55:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 12h 40m
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Greyhound US15h 5m04:20 PMDetroitCentral Bus Station6:25 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/5/2026 4:20:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/6/2026 6:25:00 AM. 50 Economy ticket for $74 per person are available. Travel duration is 15h 5m
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Greyhound US15h 55m08:20 AMDetroitCentral Bus Station11:15 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/5/2026 8:20:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/5/2026 11:15:00 PM. 50 Economy ticket for $80 per person are available. Travel duration is 15h 55m
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Greyhound US16h 0m08:20 AMDetroitCentral Bus Station11:20 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/5/2026 8:20:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/5/2026 11:20:00 PM. 50 Economy ticket for $74 per person are available. Travel duration is 16h 0m
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Greyhound US17h 25m011:15 PMDetroitCentral Bus Station3:40 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/5/2026 11:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/6/2026 3:40:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 17h 25m
Fastest Flights Friday
Fastest Buses Friday
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Skyscanner4h 28m010:55 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport2:23 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/6/2026 10:55:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/6/2026 2:23:00 PM. 50 Economy ticket for $269 per person are available. Travel duration is 4h 28m
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United Airlines6h 6m07:05 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport12:11 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/6/2026 7:05:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/6/2026 12:11:00 PM. 50 Economy ticket for $100 per person are available. Travel duration is 6h 6m
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Frontier Airlines7h 3m01:20 PMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport7:23 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/6/2026 1:20:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/6/2026 7:23:00 PM. 50 Economy ticket for $107 per person are available. Travel duration is 7h 3m
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Frontier Airlines12h 28m07:55 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport7:23 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/6/2026 7:55:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/6/2026 7:23:00 PM. 50 Economy ticket for $129 per person are available. Travel duration is 12h 28m
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Frontier Airlines25h 37m012:44 PMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport1:21 PMMidAmerica St. Louis AirportMidAmerica St. Louis Airport0EconomyA Flight from Frontier Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/6/2026 12:44:00 PM to MidAmerica St. Louis Airport, MidAmerica St. Louis Airport (USA) arriving at 6/7/2026 1:21:00 PM. 50 Economy ticket for $511 per person are available. Travel duration is 25h 37m
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Greyhound US12h 40m08:15 PMDetroitCentral Bus Station7:55 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/6/2026 8:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/7/2026 7:55:00 AM. 50 Economy ticket for $83 per person are available. Travel duration is 12h 40m
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Greyhound US15h 5m04:20 PMDetroitCentral Bus Station6:25 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/6/2026 4:20:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/7/2026 6:25:00 AM. 50 Economy ticket for $83 per person are available. Travel duration is 15h 5m
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Greyhound US15h 55m08:20 AMDetroitCentral Bus Station11:15 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/6/2026 8:20:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/6/2026 11:15:00 PM. 50 Economy ticket for $82 per person are available. Travel duration is 15h 55m
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Greyhound US17h 25m011:15 PMDetroitCentral Bus Station3:40 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/6/2026 11:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/7/2026 3:40:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 17h 25m
Fastest Flights Saturday
Fastest Buses Saturday
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United Airlines4h 21m08:50 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport12:11 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/7/2026 8:50:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/7/2026 12:11:00 PM. 50 Economy ticket for $193 per person are available. Travel duration is 4h 21m
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Skyscanner4h 42m07:47 PMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport11:29 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/7/2026 7:47:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/7/2026 11:29:00 PM. 50 Economy ticket for $203 per person are available. Travel duration is 4h 42m
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United Airlines6h 6m07:05 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport12:11 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/7/2026 7:05:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/7/2026 12:11:00 PM. 50 Economy ticket for $189 per person are available. Travel duration is 6h 6m
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Frontier Airlines11h 43m06:50 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport5:33 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/7/2026 6:50:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/7/2026 5:33:00 PM. 50 Economy ticket for $154 per person are available. Travel duration is 11h 43m
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Frontier Airlines19h 56m01:59 PMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport8:55 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/7/2026 1:59:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/8/2026 8:55:00 AM. 50 Economy ticket for $154 per person are available. Travel duration is 19h 56m
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Frontier Airlines20h 3m012:44 PMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport7:47 AMMidAmerica St. Louis AirportMidAmerica St. Louis Airport0EconomyA Flight from Frontier Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/7/2026 12:44:00 PM to MidAmerica St. Louis Airport, MidAmerica St. Louis Airport (USA) arriving at 6/8/2026 7:47:00 AM. 50 Economy ticket for $385 per person are available. Travel duration is 20h 3m
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Greyhound US12h 40m08:15 PMDetroitCentral Bus Station7:55 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/7/2026 8:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/8/2026 7:55:00 AM. 50 Economy ticket for $84 per person are available. Travel duration is 12h 40m
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Greyhound US15h 5m04:20 PMDetroitCentral Bus Station6:25 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/7/2026 4:20:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/8/2026 6:25:00 AM. 50 Economy ticket for $83 per person are available. Travel duration is 15h 5m
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Greyhound US15h 55m08:20 AMDetroitCentral Bus Station11:15 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/7/2026 8:20:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/7/2026 11:15:00 PM. 50 Economy ticket for $84 per person are available. Travel duration is 15h 55m
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Greyhound US17h 25m011:15 PMDetroitCentral Bus Station3:40 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/7/2026 11:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/8/2026 3:40:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 17h 25m
Fastest Flights Sunday
Fastest Buses Sunday
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Skyscanner4h 42m07:47 PMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport11:29 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/8/2026 7:47:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/8/2026 11:29:00 PM. 50 Economy ticket for $176 per person are available. Travel duration is 4h 42m
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United Airlines5h 46m011:00 AMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport3:46 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/8/2026 11:00:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/8/2026 3:46:00 PM. 50 Economy ticket for $126 per person are available. Travel duration is 5h 46m
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Frontier Airlines24h 25m06:05 PMDetroit Metropolitan Wayne County AirportDetroit Metropolitan Wayne County Airport5:30 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Frontier Airlines goes from Detroit Metropolitan Wayne County Airport, Detroit Metropolitan Wayne County Airport (USA) at 6/8/2026 6:05:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 6/9/2026 5:30:00 PM. 50 Economy ticket for $143 per person are available. Travel duration is 24h 25m
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Greyhound US12h 40m08:15 PMDetroitCentral Bus Station7:55 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/8/2026 8:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/9/2026 7:55:00 AM. 50 Economy ticket for $77 per person are available. Travel duration is 12h 40m
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Greyhound US15h 5m04:20 PMDetroitCentral Bus Station6:25 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/8/2026 4:20:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/9/2026 6:25:00 AM. 50 Economy ticket for $76 per person are available. Travel duration is 15h 5m
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Greyhound US15h 55m08:20 AMDetroitCentral Bus Station11:15 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/8/2026 8:20:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 6/8/2026 11:15:00 PM. 50 Economy ticket for $77 per person are available. Travel duration is 15h 55m
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Greyhound US17h 25m011:15 PMDetroitCentral Bus Station3:40 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Central Bus Station, Detroit (USA) at 6/8/2026 11:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 6/9/2026 3:40:00 PM. 50 Economy ticket for $77 per person are available. Travel duration is 17h 25m
Fastest Flights Monday
Fastest Buses Monday
Here you will find all operators and timetables for a
Bus from Detroit to St. Louis, MO
What are the most popular stations in Detroit and St. Louis, MO?
In Detroit, you will usually depart from Central Bus Station, Amtrak or Park Avenue, while in St. Louis, MO you will be arriving at Gateway Station, Lindbergh @ Hackberry NB Bus Stop or Skinker Boulevard, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to St. Louis, MO from Detroit? With 9 connections between 1 Flight and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Detroit and St. Louis, MO, you can pay as low as $62 with a Flight from Frontier Airlines.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from United Airlines: you will get to St. Louis, MO in just 4h 21m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Detroit and St. Louis, MO are Greyhound US, Frontier Airlines and United Airlines, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Detroit and St. Louis, MO is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Windsor, ON or to Sauget, IL, and look at flights from Detroit Metropolitan Wayne County Airport, and landing at St. Louis Lambert Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Detroit to St. Louis, MO?
The most popular companies between Detroit and St. Louis, MO, are Greyhound US, Frontier Airlines and United Airlines. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Greyhound US
Airlines: Frontier Airlines, United Airlines, Skyscanner and 1 more.
All you need to know when you travel from Detroit to St. Louis, MO
Check all information on comfort and services on all modes of transports from Detroit to St. Louis, MO. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Detroit to St. Louis, MO
How can I reach St. Louis, MO from Detroit?
Every day, there are on average 9 connections between Flight and Bus, with which you can get to St. Louis, MO from Detroit.
How far is St. Louis, MO from Detroit?
The distance between Detroit and St. Louis, MO is 454.7 miles.
What is the most ecofriendly mode of transport between Detroit and St. Louis, MO?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 20 kgs of CO2, a train 26 kgs, a car 124 kgs, and a flight 180 kgs.
What is the cheapest mode of transport from Detroit to St. Louis, MO?
You can get to St. Louis, MO with just $62 by taking a Flight from Frontier Airlines.
What is the fastest way to get from Detroit to St. Louis, MO?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to St. Louis, MO in just 4h 21m with a Flight from United Airlines.
More routes to Detroit and to St. Louis, MO
Looking for more options? Here you can see the most popular routes to Detroit and to St. Louis, MO. Simply click on a connection, and you’ll find all the details about the route!
