What is the best way to travel from Philadelphia to Knoxville, TN?
Looking for a trip? Compare all the available Buses and Flights for the journey to Knoxville, TN from Philadelphia. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
What is the cheapest way to reach Knoxville, TN from Philadelphia?
You can get to Knoxville, TN with just $76 by taking a Bus from FlixBus, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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FlixBus20h 0m010:00 PMPhiladelphiaSpring Garden St Station6:00 PMKnoxville, TNKnoxville Area Transit Bus Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/13/2025 10:00:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/14/2025 6:00:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 20h 0m
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Greyhound US21h 30m08:30 PMPhiladelphiaConvention Center6:00 PMKnoxville, TNKnoxville Area Transit Bus Stop0EconomyA Bus from Greyhound US goes from Convention Center, Philadelphia (USA) at 12/13/2025 8:30:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/14/2025 6:00:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 21h 30m
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Greyhound US22h 0m08:00 PMPhiladelphiaSchuylkill Ave and Walnut Street6:00 PMKnoxville, TNKnoxville Area Transit Bus Stop0EconomyA Bus from Greyhound US goes from Schuylkill Ave and Walnut Street, Philadelphia (USA) at 12/13/2025 8:00:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/14/2025 6:00:00 PM. 50 Economy ticket for $78 per person are available. Travel duration is 22h 0m
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FlixBus28h 0m02:00 PMPhiladelphiaJFK & Broad6:00 PMKnoxville, TNKnoxville Area Transit Bus Stop0EconomyA Bus from FlixBus goes from JFK & Broad, Philadelphia (USA) at 12/13/2025 2:00:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/14/2025 6:00:00 PM. 50 Economy ticket for $82 per person are available. Travel duration is 28h 0m
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FlixBus20h 0m010:00 PMPhiladelphiaSpring Garden St Station6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/13/2025 10:00:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/14/2025 6:00:00 PM. 50 Economy ticket for $90 per person are available. Travel duration is 20h 0m
Cheapest Buses Saturday
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FlixBus20h 0m010:00 PMPhiladelphiaSpring Garden St Station6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/14/2025 10:00:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/15/2025 6:00:00 PM. 50 Economy ticket for $82 per person are available. Travel duration is 20h 0m
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FlixBus20h 0m010:00 PMPhiladelphiaSpring Garden St Station6:00 PMKnoxville, TNKnoxville Area Transit Bus Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/14/2025 10:00:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/15/2025 6:00:00 PM. 50 Economy ticket for $82 per person are available. Travel duration is 20h 0m
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FlixBus16h 10m01:50 AMPhiladelphiaSpring Garden St Station6:00 PMKnoxville, TNKnoxville Area Transit Bus Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/14/2025 1:50:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/14/2025 6:00:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 16h 10m
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Greyhound US22h 0m08:00 PMPhiladelphiaSchuylkill Ave and Walnut Street6:00 PMKnoxville, TNKnoxville Area Transit Bus Stop0EconomyA Bus from Greyhound US goes from Schuylkill Ave and Walnut Street, Philadelphia (USA) at 12/14/2025 8:00:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/15/2025 6:00:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 22h 0m
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Greyhound US21h 30m08:30 PMPhiladelphiaConvention Center6:00 PMKnoxville, TNKnoxville Area Transit Bus Stop0EconomyA Bus from Greyhound US goes from Convention Center, Philadelphia (USA) at 12/14/2025 8:30:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/15/2025 6:00:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 21h 30m
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Frontier Airlines19h 21m08:36 PMPhiladelphia AirportPhiladelphia Airport3:57 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 12/14/2025 8:36:00 PM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/15/2025 3:57:00 PM. 50 Economy ticket for $112 per person are available. Travel duration is 19h 21m
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Frontier Airlines14h 48m05:45 PMPhiladelphia AirportPhiladelphia Airport8:33 AMKnoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 12/14/2025 5:45:00 PM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/15/2025 8:33:00 AM. 50 Economy ticket for $132 per person are available. Travel duration is 14h 48m
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Spirit Airlines7h 2m05:30 AMPhiladelphia AirportPhiladelphia Airport12:32 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 12/14/2025 5:30:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/14/2025 12:32:00 PM. 50 Economy ticket for $143 per person are available. Travel duration is 7h 2m
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United Airlines6h 47m06:30 AMPhiladelphia AirportPhiladelphia Airport1:17 PMKnoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 12/14/2025 6:30:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/14/2025 1:17:00 PM. 50 Economy ticket for $481 per person are available. Travel duration is 6h 47m
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United Airlines6h 56m010:15 AMPhiladelphia AirportPhiladelphia Airport5:11 PMKnoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 12/14/2025 10:15:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/14/2025 5:11:00 PM. 50 Economy ticket for $481 per person are available. Travel duration is 6h 56m
Cheapest Buses Sunday
Cheapest Flights Sunday
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Frontier Airlines18h 2m010:00 PMPhiladelphia AirportPhiladelphia Airport4:02 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 12/15/2025 10:00:00 PM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/16/2025 4:02:00 PM. 50 Economy ticket for $100 per person are available. Travel duration is 18h 2m
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Spirit Airlines11h 50m05:30 AMPhiladelphia AirportPhiladelphia Airport5:20 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 12/15/2025 5:30:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/15/2025 5:20:00 PM. 50 Economy ticket for $124 per person are available. Travel duration is 11h 50m
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Frontier Airlines11h 20m06:00 AMPhiladelphia AirportPhiladelphia Airport5:20 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 12/15/2025 6:00:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/15/2025 5:20:00 PM. 50 Economy ticket for $124 per person are available. Travel duration is 11h 20m
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United Airlines6h 47m06:30 AMPhiladelphia AirportPhiladelphia Airport1:17 PMKnoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 12/15/2025 6:30:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/15/2025 1:17:00 PM. 50 Economy ticket for $481 per person are available. Travel duration is 6h 47m
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United Airlines6h 56m010:15 AMPhiladelphia AirportPhiladelphia Airport5:11 PMKnoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 12/15/2025 10:15:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/15/2025 5:11:00 PM. 50 Economy ticket for $481 per person are available. Travel duration is 6h 56m
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FlixBus20h 0m010:00 PMPhiladelphiaSpring Garden St Station6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/15/2025 10:00:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/16/2025 6:00:00 PM. 50 Economy ticket for $128 per person are available. Travel duration is 20h 0m
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Greyhound US16h 0m02:00 AMPhiladelphiaIRS Building6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from IRS Building, Philadelphia (USA) at 12/15/2025 2:00:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/15/2025 6:00:00 PM. 50 Economy ticket for $129 per person are available. Travel duration is 16h 0m
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FlixBus16h 10m01:50 AMPhiladelphiaSpring Garden St Station6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/15/2025 1:50:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/15/2025 6:00:00 PM. 50 Economy ticket for $130 per person are available. Travel duration is 16h 10m
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Greyhound US21h 30m08:30 PMPhiladelphiaSpring Garden St Station6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Spring Garden St Station, Philadelphia (USA) at 12/15/2025 8:30:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/16/2025 6:00:00 PM. 50 Economy ticket for $130 per person are available. Travel duration is 21h 30m
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Greyhound US22h 0m08:00 PMPhiladelphiaIRS Building6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from IRS Building, Philadelphia (USA) at 12/15/2025 8:00:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/16/2025 6:00:00 PM. 50 Economy ticket for $130 per person are available. Travel duration is 22h 0m
Cheapest Flights Monday
Cheapest Buses Monday
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FlixBus20h 0m010:00 PMPhiladelphiaSpring Garden St Station6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/16/2025 10:00:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/17/2025 6:00:00 PM. 50 Economy ticket for $97 per person are available. Travel duration is 20h 0m
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Greyhound US16h 0m02:00 AMPhiladelphiaIRS Building6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from IRS Building, Philadelphia (USA) at 12/16/2025 2:00:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/16/2025 6:00:00 PM. 50 Economy ticket for $97 per person are available. Travel duration is 16h 0m
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FlixBus16h 10m01:50 AMPhiladelphiaSpring Garden St Station6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/16/2025 1:50:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/16/2025 6:00:00 PM. 50 Economy ticket for $98 per person are available. Travel duration is 16h 10m
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Greyhound US21h 30m08:30 PMPhiladelphiaSpring Garden St Station6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Spring Garden St Station, Philadelphia (USA) at 12/16/2025 8:30:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/17/2025 6:00:00 PM. 50 Economy ticket for $98 per person are available. Travel duration is 21h 30m
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Greyhound US22h 0m08:00 PMPhiladelphiaIRS Building6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from IRS Building, Philadelphia (USA) at 12/16/2025 8:00:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/17/2025 6:00:00 PM. 50 Economy ticket for $98 per person are available. Travel duration is 22h 0m
Cheapest Buses Tuesday
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Greyhound US21h 30m08:30 PMPhiladelphiaSpring Garden St Station6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Spring Garden St Station, Philadelphia (USA) at 12/18/2025 8:30:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/19/2025 6:00:00 PM. 50 Economy ticket for $141 per person are available. Travel duration is 21h 30m
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Greyhound US22h 0m08:00 PMPhiladelphiaIRS Building6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from IRS Building, Philadelphia (USA) at 12/18/2025 8:00:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/19/2025 6:00:00 PM. 50 Economy ticket for $141 per person are available. Travel duration is 22h 0m
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Greyhound US16h 0m02:00 AMPhiladelphiaIRS Building6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from IRS Building, Philadelphia (USA) at 12/18/2025 2:00:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/18/2025 6:00:00 PM. 50 Economy ticket for $142 per person are available. Travel duration is 16h 0m
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FlixBus16h 10m01:50 AMPhiladelphiaSpring Garden St Station6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/18/2025 1:50:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/18/2025 6:00:00 PM. 50 Economy ticket for $146 per person are available. Travel duration is 16h 10m
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FlixBus23h 15m06:45 PMPhiladelphiaSpring Garden St Station6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/18/2025 6:45:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/19/2025 6:00:00 PM. 50 Economy ticket for $147 per person are available. Travel duration is 23h 15m
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Frontier Airlines8h 36m05:30 AMPhiladelphia AirportPhiladelphia Airport2:06 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 12/18/2025 5:30:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/18/2025 2:06:00 PM. 50 Economy ticket for $181 per person are available. Travel duration is 8h 36m
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Frontier Airlines7h 38m01:35 PMPhiladelphia AirportPhiladelphia Airport9:13 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 12/18/2025 1:35:00 PM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/18/2025 9:13:00 PM. 50 Economy ticket for $181 per person are available. Travel duration is 7h 38m
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Spirit Airlines7h 7m05:25 AMPhiladelphia AirportPhiladelphia Airport12:32 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 12/18/2025 5:25:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/18/2025 12:32:00 PM. 50 Economy ticket for $203 per person are available. Travel duration is 7h 7m
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Spirit Airlines7h 56m06:10 AMPhiladelphia AirportPhiladelphia Airport2:06 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 12/18/2025 6:10:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/18/2025 2:06:00 PM. 50 Economy ticket for $229 per person are available. Travel duration is 7h 56m
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Skyscanner4h 9m010:39 AMPhiladelphia AirportPhiladelphia Airport2:48 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Skyscanner goes from Philadelphia Airport, Philadelphia Airport (USA) at 12/18/2025 10:39:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/18/2025 2:48:00 PM. 50 Economy ticket for $482 per person are available. Travel duration is 4h 9m
Cheapest Buses Thursday
Cheapest Flights Thursday
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FlixBus16h 10m01:50 AMPhiladelphiaSpring Garden St Station6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/19/2025 1:50:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/19/2025 6:00:00 PM. 50 Economy ticket for $155 per person are available. Travel duration is 16h 10m
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Greyhound US16h 0m02:00 AMPhiladelphiaIRS Building6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from IRS Building, Philadelphia (USA) at 12/19/2025 2:00:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/19/2025 6:00:00 PM. 50 Economy ticket for $155 per person are available. Travel duration is 16h 0m
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FlixBus20h 0m010:00 PMPhiladelphiaSpring Garden St Station6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/19/2025 10:00:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/20/2025 6:00:00 PM. 50 Economy ticket for $164 per person are available. Travel duration is 20h 0m
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Greyhound US21h 30m08:30 PMPhiladelphiaSpring Garden St Station6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Spring Garden St Station, Philadelphia (USA) at 12/19/2025 8:30:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/20/2025 6:00:00 PM. 50 Economy ticket for $165 per person are available. Travel duration is 21h 30m
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FlixBus28h 0m02:00 PMPhiladelphiaJFK & Broad6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from JFK & Broad, Philadelphia (USA) at 12/19/2025 2:00:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/20/2025 6:00:00 PM. 50 Economy ticket for $175 per person are available. Travel duration is 28h 0m
Cheapest Buses Friday
What are the fastest trips from Philadelphia to Knoxville, TN?
You can get to Knoxville, TN from Philadelphia in just 4h 9m with a Flight from Skyscanner. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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FlixBus20h 0m010:00 PMPhiladelphiaSpring Garden St Station6:00 PMKnoxville, TNKnoxville Area Transit Bus Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/13/2025 10:00:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/14/2025 6:00:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 20h 0m
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FlixBus20h 0m010:00 PMPhiladelphiaSpring Garden St Station6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/13/2025 10:00:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/14/2025 6:00:00 PM. 50 Economy ticket for $90 per person are available. Travel duration is 20h 0m
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Greyhound US21h 30m08:30 PMPhiladelphiaConvention Center6:00 PMKnoxville, TNKnoxville Area Transit Bus Stop0EconomyA Bus from Greyhound US goes from Convention Center, Philadelphia (USA) at 12/13/2025 8:30:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/14/2025 6:00:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 21h 30m
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Greyhound US22h 0m08:00 PMPhiladelphiaSchuylkill Ave and Walnut Street6:00 PMKnoxville, TNKnoxville Area Transit Bus Stop0EconomyA Bus from Greyhound US goes from Schuylkill Ave and Walnut Street, Philadelphia (USA) at 12/13/2025 8:00:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/14/2025 6:00:00 PM. 50 Economy ticket for $78 per person are available. Travel duration is 22h 0m
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FlixBus28h 0m02:00 PMPhiladelphiaJFK & Broad6:00 PMKnoxville, TNKnoxville Area Transit Bus Stop0EconomyA Bus from FlixBus goes from JFK & Broad, Philadelphia (USA) at 12/13/2025 2:00:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/14/2025 6:00:00 PM. 50 Economy ticket for $82 per person are available. Travel duration is 28h 0m
Fastest Buses Saturday
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United Airlines6h 47m06:30 AMPhiladelphia AirportPhiladelphia Airport1:17 PMKnoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 12/14/2025 6:30:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/14/2025 1:17:00 PM. 50 Economy ticket for $481 per person are available. Travel duration is 6h 47m
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United Airlines6h 56m010:15 AMPhiladelphia AirportPhiladelphia Airport5:11 PMKnoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 12/14/2025 10:15:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/14/2025 5:11:00 PM. 50 Economy ticket for $481 per person are available. Travel duration is 6h 56m
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Spirit Airlines7h 2m05:30 AMPhiladelphia AirportPhiladelphia Airport12:32 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 12/14/2025 5:30:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/14/2025 12:32:00 PM. 50 Economy ticket for $143 per person are available. Travel duration is 7h 2m
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Frontier Airlines14h 48m05:45 PMPhiladelphia AirportPhiladelphia Airport8:33 AMKnoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 12/14/2025 5:45:00 PM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/15/2025 8:33:00 AM. 50 Economy ticket for $132 per person are available. Travel duration is 14h 48m
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Frontier Airlines19h 21m08:36 PMPhiladelphia AirportPhiladelphia Airport3:57 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 12/14/2025 8:36:00 PM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/15/2025 3:57:00 PM. 50 Economy ticket for $112 per person are available. Travel duration is 19h 21m
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FlixBus16h 10m01:50 AMPhiladelphiaSpring Garden St Station6:00 PMKnoxville, TNKnoxville Area Transit Bus Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/14/2025 1:50:00 AM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/14/2025 6:00:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 16h 10m
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FlixBus20h 0m010:00 PMPhiladelphiaSpring Garden St Station6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/14/2025 10:00:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/15/2025 6:00:00 PM. 50 Economy ticket for $82 per person are available. Travel duration is 20h 0m
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FlixBus20h 0m010:00 PMPhiladelphiaSpring Garden St Station6:00 PMKnoxville, TNKnoxville Area Transit Bus Stop0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/14/2025 10:00:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/15/2025 6:00:00 PM. 50 Economy ticket for $82 per person are available. Travel duration is 20h 0m
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Greyhound US21h 30m08:30 PMPhiladelphiaConvention Center6:00 PMKnoxville, TNKnoxville Area Transit Bus Stop0EconomyA Bus from Greyhound US goes from Convention Center, Philadelphia (USA) at 12/14/2025 8:30:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/15/2025 6:00:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 21h 30m
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Greyhound US22h 0m08:00 PMPhiladelphiaSchuylkill Ave and Walnut Street6:00 PMKnoxville, TNKnoxville Area Transit Bus Stop0EconomyA Bus from Greyhound US goes from Schuylkill Ave and Walnut Street, Philadelphia (USA) at 12/14/2025 8:00:00 PM to Knoxville Area Transit Bus Stop, Knoxville, TN (USA) arriving at 12/15/2025 6:00:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 22h 0m
Fastest Flights Sunday
Fastest Buses Sunday
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United Airlines6h 47m06:30 AMPhiladelphia AirportPhiladelphia Airport1:17 PMKnoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 12/15/2025 6:30:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/15/2025 1:17:00 PM. 50 Economy ticket for $481 per person are available. Travel duration is 6h 47m
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United Airlines6h 56m010:15 AMPhiladelphia AirportPhiladelphia Airport5:11 PMKnoxville AirportKnoxville Airport0EconomyA Flight from United Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 12/15/2025 10:15:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/15/2025 5:11:00 PM. 50 Economy ticket for $481 per person are available. Travel duration is 6h 56m
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Frontier Airlines11h 20m06:00 AMPhiladelphia AirportPhiladelphia Airport5:20 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 12/15/2025 6:00:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/15/2025 5:20:00 PM. 50 Economy ticket for $124 per person are available. Travel duration is 11h 20m
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Spirit Airlines11h 50m05:30 AMPhiladelphia AirportPhiladelphia Airport5:20 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 12/15/2025 5:30:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/15/2025 5:20:00 PM. 50 Economy ticket for $124 per person are available. Travel duration is 11h 50m
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Frontier Airlines18h 2m010:00 PMPhiladelphia AirportPhiladelphia Airport4:02 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 12/15/2025 10:00:00 PM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/16/2025 4:02:00 PM. 50 Economy ticket for $100 per person are available. Travel duration is 18h 2m
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Greyhound US16h 0m02:00 AMPhiladelphiaIRS Building6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from IRS Building, Philadelphia (USA) at 12/15/2025 2:00:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/15/2025 6:00:00 PM. 50 Economy ticket for $129 per person are available. Travel duration is 16h 0m
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FlixBus16h 10m01:50 AMPhiladelphiaSpring Garden St Station6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/15/2025 1:50:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/15/2025 6:00:00 PM. 50 Economy ticket for $130 per person are available. Travel duration is 16h 10m
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FlixBus20h 0m010:00 PMPhiladelphiaSpring Garden St Station6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/15/2025 10:00:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/16/2025 6:00:00 PM. 50 Economy ticket for $128 per person are available. Travel duration is 20h 0m
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Greyhound US21h 30m08:30 PMPhiladelphiaSpring Garden St Station6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Spring Garden St Station, Philadelphia (USA) at 12/15/2025 8:30:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/16/2025 6:00:00 PM. 50 Economy ticket for $130 per person are available. Travel duration is 21h 30m
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Greyhound US22h 0m08:00 PMPhiladelphiaIRS Building6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from IRS Building, Philadelphia (USA) at 12/15/2025 8:00:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/16/2025 6:00:00 PM. 50 Economy ticket for $130 per person are available. Travel duration is 22h 0m
Fastest Flights Monday
Fastest Buses Monday
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Greyhound US16h 0m02:00 AMPhiladelphiaIRS Building6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from IRS Building, Philadelphia (USA) at 12/16/2025 2:00:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/16/2025 6:00:00 PM. 50 Economy ticket for $97 per person are available. Travel duration is 16h 0m
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FlixBus16h 10m01:50 AMPhiladelphiaSpring Garden St Station6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/16/2025 1:50:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/16/2025 6:00:00 PM. 50 Economy ticket for $98 per person are available. Travel duration is 16h 10m
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FlixBus20h 0m010:00 PMPhiladelphiaSpring Garden St Station6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/16/2025 10:00:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/17/2025 6:00:00 PM. 50 Economy ticket for $97 per person are available. Travel duration is 20h 0m
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Greyhound US21h 30m08:30 PMPhiladelphiaSpring Garden St Station6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Spring Garden St Station, Philadelphia (USA) at 12/16/2025 8:30:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/17/2025 6:00:00 PM. 50 Economy ticket for $98 per person are available. Travel duration is 21h 30m
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Greyhound US22h 0m08:00 PMPhiladelphiaIRS Building6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from IRS Building, Philadelphia (USA) at 12/16/2025 8:00:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/17/2025 6:00:00 PM. 50 Economy ticket for $98 per person are available. Travel duration is 22h 0m
Fastest Buses Tuesday
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Skyscanner4h 9m010:39 AMPhiladelphia AirportPhiladelphia Airport2:48 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Skyscanner goes from Philadelphia Airport, Philadelphia Airport (USA) at 12/18/2025 10:39:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/18/2025 2:48:00 PM. 50 Economy ticket for $482 per person are available. Travel duration is 4h 9m
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Spirit Airlines7h 7m05:25 AMPhiladelphia AirportPhiladelphia Airport12:32 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 12/18/2025 5:25:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/18/2025 12:32:00 PM. 50 Economy ticket for $203 per person are available. Travel duration is 7h 7m
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Frontier Airlines7h 38m01:35 PMPhiladelphia AirportPhiladelphia Airport9:13 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 12/18/2025 1:35:00 PM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/18/2025 9:13:00 PM. 50 Economy ticket for $181 per person are available. Travel duration is 7h 38m
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Spirit Airlines7h 56m06:10 AMPhiladelphia AirportPhiladelphia Airport2:06 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Spirit Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 12/18/2025 6:10:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/18/2025 2:06:00 PM. 50 Economy ticket for $229 per person are available. Travel duration is 7h 56m
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Frontier Airlines8h 36m05:30 AMPhiladelphia AirportPhiladelphia Airport2:06 PMKnoxville AirportKnoxville Airport0EconomyA Flight from Frontier Airlines goes from Philadelphia Airport, Philadelphia Airport (USA) at 12/18/2025 5:30:00 AM to Knoxville Airport, Knoxville Airport (USA) arriving at 12/18/2025 2:06:00 PM. 50 Economy ticket for $181 per person are available. Travel duration is 8h 36m
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Greyhound US16h 0m02:00 AMPhiladelphiaIRS Building6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from IRS Building, Philadelphia (USA) at 12/18/2025 2:00:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/18/2025 6:00:00 PM. 50 Economy ticket for $142 per person are available. Travel duration is 16h 0m
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FlixBus16h 10m01:50 AMPhiladelphiaSpring Garden St Station6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/18/2025 1:50:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/18/2025 6:00:00 PM. 50 Economy ticket for $146 per person are available. Travel duration is 16h 10m
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Greyhound US21h 30m08:30 PMPhiladelphiaSpring Garden St Station6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Spring Garden St Station, Philadelphia (USA) at 12/18/2025 8:30:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/19/2025 6:00:00 PM. 50 Economy ticket for $141 per person are available. Travel duration is 21h 30m
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Greyhound US22h 0m08:00 PMPhiladelphiaIRS Building6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from IRS Building, Philadelphia (USA) at 12/18/2025 8:00:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/19/2025 6:00:00 PM. 50 Economy ticket for $141 per person are available. Travel duration is 22h 0m
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FlixBus23h 15m06:45 PMPhiladelphiaSpring Garden St Station6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/18/2025 6:45:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/19/2025 6:00:00 PM. 50 Economy ticket for $147 per person are available. Travel duration is 23h 15m
Fastest Flights Thursday
Fastest Buses Thursday
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Greyhound US16h 0m02:00 AMPhiladelphiaIRS Building6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from IRS Building, Philadelphia (USA) at 12/19/2025 2:00:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/19/2025 6:00:00 PM. 50 Economy ticket for $155 per person are available. Travel duration is 16h 0m
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FlixBus16h 10m01:50 AMPhiladelphiaSpring Garden St Station6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/19/2025 1:50:00 AM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/19/2025 6:00:00 PM. 50 Economy ticket for $155 per person are available. Travel duration is 16h 10m
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FlixBus20h 0m010:00 PMPhiladelphiaSpring Garden St Station6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/19/2025 10:00:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/20/2025 6:00:00 PM. 50 Economy ticket for $164 per person are available. Travel duration is 20h 0m
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Greyhound US21h 30m08:30 PMPhiladelphiaSpring Garden St Station6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from Greyhound US goes from Spring Garden St Station, Philadelphia (USA) at 12/19/2025 8:30:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/20/2025 6:00:00 PM. 50 Economy ticket for $165 per person are available. Travel duration is 21h 30m
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FlixBus28h 0m02:00 PMPhiladelphiaJFK & Broad6:00 PMKnoxville, TNGreyhound Bus Station0EconomyA Bus from FlixBus goes from JFK & Broad, Philadelphia (USA) at 12/19/2025 2:00:00 PM to Greyhound Bus Station, Knoxville, TN (USA) arriving at 12/20/2025 6:00:00 PM. 50 Economy ticket for $175 per person are available. Travel duration is 28h 0m
Fastest Buses Friday
Here you will find all operators and timetables for a
Bus from Philadelphia to Knoxville, TN
What are the most popular stations in Philadelphia and Knoxville, TN?
In Philadelphia, you will usually depart from Spring Garden St Station, 30th Street Station or The Gallery, while in Knoxville, TN you will be arriving at Knoxville Area Transit Bus Stop, Greyhound Bus Station or Transit Center, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Knoxville, TN from Philadelphia? With 7 connections between 2 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Philadelphia and Knoxville, TN, you can pay as low as $76 with a Bus from FlixBus.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from Skyscanner: you will get to Knoxville, TN in just 4h 9m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Philadelphia and Knoxville, TN are FlixBus, Greyhound US and Frontier Airlines, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Philadelphia and Knoxville, TN is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Millbourne, PA or to Wildwood, TN, and look at flights from Philadelphia Airport, and landing at Knoxville Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Philadelphia to Knoxville, TN?
The most popular companies between Philadelphia and Knoxville, TN, are FlixBus, Greyhound US and Frontier Airlines. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus and Greyhound US
Airlines: Frontier Airlines, Spirit Airlines, United Airlines and 1 more.
All you need to know when you travel from Philadelphia to Knoxville, TN
Check all information on comfort and services on all modes of transports from Philadelphia to Knoxville, TN. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Philadelphia to Knoxville, TN
How can I reach Knoxville, TN from Philadelphia?
Every day, there are on average 7 connections between Bus and Flight, with which you can get to Knoxville, TN from Philadelphia.
How far is Knoxville, TN from Philadelphia?
The distance between Philadelphia and Knoxville, TN is 549.6 miles.
What is the most ecofriendly mode of transport between Philadelphia and Knoxville, TN?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 24 kgs of CO2, a train 31 kgs, a car 150 kgs, and a flight 218 kgs.
What is the cheapest mode of transport from Philadelphia to Knoxville, TN?
You can get to Knoxville, TN with just $76 by taking a Bus from FlixBus.
What is the fastest way to get from Philadelphia to Knoxville, TN?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Knoxville, TN in just 4h 9m with a Flight from Skyscanner.
More routes to Philadelphia and to Knoxville, TN
Looking for more options? Here you can see the most popular routes to Philadelphia and to Knoxville, TN. Simply click on a connection, and you’ll find all the details about the route!

