What is the best way to travel from Rome to Brussels?
Looking for a trip? Compare all the available Buses and Flights for the journey to Brussels from Rome. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 1 available companies to find your perfect trip!
What is the cheapest way to reach Brussels from Rome?
You can get to Brussels with just $85 by taking a Flight from Wizz Air, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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FlixBus27h 25m012:10 AMRomeTiburtina Bus Station3:35 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/5/2025 12:10:00 AM to North Station, Brussels (Belgium) arriving at 12/6/2025 3:35:00 AM. 50 Economy ticket for $107 per person are available. Travel duration is 27h 25m
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FlixBus32h 50m011:50 PMRomeTiburtina Bus Station8:40 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/5/2025 11:50:00 PM to North Station, Brussels (Belgium) arriving at 12/7/2025 8:40:00 AM. 50 Economy ticket for $116 per person are available. Travel duration is 32h 50m
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FlixBus24h 0m08:30 AMRomeTiburtina Bus Station8:30 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/5/2025 8:30:00 AM to North Station, Brussels (Belgium) arriving at 12/6/2025 8:30:00 AM. 50 Economy ticket for $128 per person are available. Travel duration is 24h 0m
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FlixBus29h 40m08:00 PMRomeTiburtina Bus Station1:40 AMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/5/2025 8:00:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 12/7/2025 1:40:00 AM. 50 Economy ticket for $128 per person are available. Travel duration is 29h 40m
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FlixBus26h 30m01:05 PMRomeAnagnina Bus Station3:35 PMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 12/5/2025 1:05:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 12/6/2025 3:35:00 PM. 50 Economy ticket for $128 per person are available. Travel duration is 26h 30m
Cheapest Buses Friday
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Wizz Air23h 25m08:40 PMRome Fiumicino AirportRome Fiumicino Airport8:05 PMBrussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from Wizz Air goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/7/2025 8:40:00 PM to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 12/8/2025 8:05:00 PM. 50 Economy ticket for $85 per person are available. Travel duration is 23h 25m
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Wizz Air22h 40m08:40 PMRome Fiumicino AirportRome Fiumicino Airport7:20 PMBrussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from Wizz Air goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/7/2025 8:40:00 PM to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 12/8/2025 7:20:00 PM. 50 Economy ticket for $90 per person are available. Travel duration is 22h 40m
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Ryanair2h 10m09:05 AMRome Ciampino AirportRome Ciampino Airport11:15 AMBrussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from Ryanair goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 12/7/2025 9:05:00 AM to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 12/7/2025 11:15:00 AM. 50 Economy ticket for $109 per person are available. Travel duration is 2h 10m
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EasyJet Airline2h 20m06:20 AMRome Fiumicino AirportRome Fiumicino Airport8:40 AMBrussels AirportBrussels Airport0EconomyA Flight from EasyJet Airline goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/7/2025 6:20:00 AM to Brussels Airport, Brussels Airport (Belgium) arriving at 12/7/2025 8:40:00 AM. 50 Economy ticket for $117 per person are available. Travel duration is 2h 20m
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Skyscanner2h 10m05:00 PMRome Ciampino AirportRome Ciampino Airport7:10 PMBrussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from Skyscanner goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 12/7/2025 5:00:00 PM to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 12/7/2025 7:10:00 PM. 50 Economy ticket for $126 per person are available. Travel duration is 2h 10m
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LC Perú31h 5m06:40 AMRome Fiumicino AirportRome Fiumicino Airport1:45 PMAntwerp AirportAntwerp Airport0EconomyA Flight from LC Perú goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/7/2025 6:40:00 AM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/8/2025 1:45:00 PM. 50 Economy ticket for $140 per person are available. Travel duration is 31h 5m
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FlixBus22h 30m010:10 AMRomeTiburtina Bus Station8:40 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/7/2025 10:10:00 AM to North Station, Brussels (Belgium) arriving at 12/8/2025 8:40:00 AM. 50 Economy ticket for $96 per person are available. Travel duration is 22h 30m
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FlixBus24h 25m011:10 AMRomeAnagnina Bus Station11:35 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 12/7/2025 11:10:00 AM to North Station, Brussels (Belgium) arriving at 12/8/2025 11:35:00 AM. 50 Economy ticket for $96 per person are available. Travel duration is 24h 25m
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FlixBus32h 25m010:55 PMRomeTiburtina Bus Station7:20 AMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/7/2025 10:55:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 12/9/2025 7:20:00 AM. 50 Economy ticket for $102 per person are available. Travel duration is 32h 25m
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FlixBus26h 50m012:10 AMRomeTiburtina Bus Station3:00 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/7/2025 12:10:00 AM to North Station, Brussels (Belgium) arriving at 12/8/2025 3:00:00 AM. 50 Economy ticket for $106 per person are available. Travel duration is 26h 50m
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FlixBus24h 0m08:30 AMRomeTiburtina Bus Station8:30 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/7/2025 8:30:00 AM to North Station, Brussels (Belgium) arriving at 12/8/2025 8:30:00 AM. 50 Economy ticket for $106 per person are available. Travel duration is 24h 0m
Cheapest Flights Sunday
Cheapest Buses Sunday
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FlixBus27h 25m012:10 AMRomeTiburtina Bus Station3:35 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/8/2025 12:10:00 AM to North Station, Brussels (Belgium) arriving at 12/9/2025 3:35:00 AM. 50 Economy ticket for $109 per person are available. Travel duration is 27h 25m
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FlixBus32h 5m012:10 AMRomeTiburtina Bus Station8:15 AMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/8/2025 12:10:00 AM to Midi Bus Station, Brussels (Belgium) arriving at 12/9/2025 8:15:00 AM. 50 Economy ticket for $109 per person are available. Travel duration is 32h 5m
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FlixBus33h 30m010:45 PMRomeTiburtina Bus Station8:15 AMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/8/2025 10:45:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 12/10/2025 8:15:00 AM. 50 Economy ticket for $111 per person are available. Travel duration is 33h 30m
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FlixBus29h 10m01:05 PMRomeAnagnina Bus Station6:15 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 12/8/2025 1:05:00 PM to North Station, Brussels (Belgium) arriving at 12/9/2025 6:15:00 PM. 50 Economy ticket for $121 per person are available. Travel duration is 29h 10m
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FlixBus23h 15m09:25 AMRomeTiburtina Bus Station8:40 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/8/2025 9:25:00 AM to North Station, Brussels (Belgium) arriving at 12/9/2025 8:40:00 AM. 50 Economy ticket for $127 per person are available. Travel duration is 23h 15m
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LC Perú7h 5m06:40 AMRome Fiumicino AirportRome Fiumicino Airport1:45 PMAntwerp AirportAntwerp Airport0EconomyA Flight from LC Perú goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/8/2025 6:40:00 AM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/8/2025 1:45:00 PM. 50 Economy ticket for $176 per person are available. Travel duration is 7h 5m
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Skyscanner7h 35m06:10 AMRome Fiumicino AirportRome Fiumicino Airport1:45 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Skyscanner goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/8/2025 6:10:00 AM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/8/2025 1:45:00 PM. 50 Economy ticket for $410 per person are available. Travel duration is 7h 35m
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LC Perú7h 40m011:55 AMRome Fiumicino AirportRome Fiumicino Airport7:35 PMAntwerp AirportAntwerp Airport0EconomyA Flight from LC Perú goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/8/2025 11:55:00 AM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/8/2025 7:35:00 PM. 50 Economy ticket for $410 per person are available. Travel duration is 7h 40m
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Ryanair6h 35m01:00 PMRome Fiumicino AirportRome Fiumicino Airport7:35 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Ryanair goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/8/2025 1:00:00 PM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/8/2025 7:35:00 PM. 50 Economy ticket for $560 per person are available. Travel duration is 6h 35m
Cheapest Buses Monday
Cheapest Flights Monday
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LC Perú31h 5m06:40 AMRome Fiumicino AirportRome Fiumicino Airport1:45 PMAntwerp AirportAntwerp Airport0EconomyA Flight from LC Perú goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/10/2025 6:40:00 AM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/11/2025 1:45:00 PM. 50 Economy ticket for $144 per person are available. Travel duration is 31h 5m
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Vueling Airlines18h 15m07:30 PMRome Fiumicino AirportRome Fiumicino Airport1:45 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Vueling Airlines goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/10/2025 7:30:00 PM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/11/2025 1:45:00 PM. 50 Economy ticket for $176 per person are available. Travel duration is 18h 15m
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Aeronova19h 20m06:25 PMRome Fiumicino AirportRome Fiumicino Airport1:45 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Aeronova goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/10/2025 6:25:00 PM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/11/2025 1:45:00 PM. 50 Economy ticket for $184 per person are available. Travel duration is 19h 20m
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Ryanair17h 15m08:30 PMRome Fiumicino AirportRome Fiumicino Airport1:45 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Ryanair goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/10/2025 8:30:00 PM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/11/2025 1:45:00 PM. 50 Economy ticket for $198 per person are available. Travel duration is 17h 15m
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ITA Airways16h 20m09:25 PMRome Fiumicino AirportRome Fiumicino Airport1:45 PMAntwerp AirportAntwerp Airport0EconomyA Flight from ITA Airways goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/10/2025 9:25:00 PM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/11/2025 1:45:00 PM. 50 Economy ticket for $204 per person are available. Travel duration is 16h 20m
Cheapest Flights Wednesday
What are the fastest trips from Rome to Brussels?
You can get to Brussels from Rome in just 2h 10m with a Flight from Ryanair. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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FlixBus24h 0m08:30 AMRomeTiburtina Bus Station8:30 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/5/2025 8:30:00 AM to North Station, Brussels (Belgium) arriving at 12/6/2025 8:30:00 AM. 50 Economy ticket for $128 per person are available. Travel duration is 24h 0m
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FlixBus26h 30m01:05 PMRomeAnagnina Bus Station3:35 PMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 12/5/2025 1:05:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 12/6/2025 3:35:00 PM. 50 Economy ticket for $128 per person are available. Travel duration is 26h 30m
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FlixBus27h 25m012:10 AMRomeTiburtina Bus Station3:35 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/5/2025 12:10:00 AM to North Station, Brussels (Belgium) arriving at 12/6/2025 3:35:00 AM. 50 Economy ticket for $107 per person are available. Travel duration is 27h 25m
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FlixBus29h 40m08:00 PMRomeTiburtina Bus Station1:40 AMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/5/2025 8:00:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 12/7/2025 1:40:00 AM. 50 Economy ticket for $128 per person are available. Travel duration is 29h 40m
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FlixBus32h 50m011:50 PMRomeTiburtina Bus Station8:40 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/5/2025 11:50:00 PM to North Station, Brussels (Belgium) arriving at 12/7/2025 8:40:00 AM. 50 Economy ticket for $116 per person are available. Travel duration is 32h 50m
Fastest Buses Friday
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Ryanair2h 10m09:05 AMRome Ciampino AirportRome Ciampino Airport11:15 AMBrussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from Ryanair goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 12/7/2025 9:05:00 AM to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 12/7/2025 11:15:00 AM. 50 Economy ticket for $109 per person are available. Travel duration is 2h 10m
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Skyscanner2h 10m05:00 PMRome Ciampino AirportRome Ciampino Airport7:10 PMBrussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from Skyscanner goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 12/7/2025 5:00:00 PM to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 12/7/2025 7:10:00 PM. 50 Economy ticket for $126 per person are available. Travel duration is 2h 10m
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Ryanair2h 10m01:35 PMRome Ciampino AirportRome Ciampino Airport3:45 PMBrussels South Charleroi AirportBrussels South Charleroi Airport0EconomyA Flight from Ryanair goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 12/7/2025 1:35:00 PM to Brussels South Charleroi Airport, Brussels South Charleroi Airport (Belgium) arriving at 12/7/2025 3:45:00 PM. 50 Economy ticket for $141 per person are available. Travel duration is 2h 10m
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Skyscanner2h 10m04:45 PMRome Fiumicino AirportRome Fiumicino Airport6:55 PMBrussels AirportBrussels Airport0EconomyA Flight from Skyscanner goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/7/2025 4:45:00 PM to Brussels Airport, Brussels Airport (Belgium) arriving at 12/7/2025 6:55:00 PM. 50 Economy ticket for $189 per person are available. Travel duration is 2h 10m
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EasyJet Airline2h 20m06:20 AMRome Fiumicino AirportRome Fiumicino Airport8:40 AMBrussels AirportBrussels Airport0EconomyA Flight from EasyJet Airline goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/7/2025 6:20:00 AM to Brussels Airport, Brussels Airport (Belgium) arriving at 12/7/2025 8:40:00 AM. 50 Economy ticket for $117 per person are available. Travel duration is 2h 20m
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LC Perú7h 15m06:40 AMRome Fiumicino AirportRome Fiumicino Airport1:55 PMBrussels AirportBrussels Airport0EconomyA Flight from LC Perú goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/7/2025 6:40:00 AM to Brussels Airport, Brussels Airport (Belgium) arriving at 12/7/2025 1:55:00 PM. 50 Economy ticket for $157 per person are available. Travel duration is 7h 15m
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FlixBus22h 30m010:10 AMRomeTiburtina Bus Station8:40 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/7/2025 10:10:00 AM to North Station, Brussels (Belgium) arriving at 12/8/2025 8:40:00 AM. 50 Economy ticket for $96 per person are available. Travel duration is 22h 30m
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FlixBus24h 0m08:30 AMRomeTiburtina Bus Station8:30 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/7/2025 8:30:00 AM to North Station, Brussels (Belgium) arriving at 12/8/2025 8:30:00 AM. 50 Economy ticket for $106 per person are available. Travel duration is 24h 0m
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FlixBus24h 25m011:10 AMRomeAnagnina Bus Station11:35 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 12/7/2025 11:10:00 AM to North Station, Brussels (Belgium) arriving at 12/8/2025 11:35:00 AM. 50 Economy ticket for $96 per person are available. Travel duration is 24h 25m
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FlixBus26h 50m012:10 AMRomeTiburtina Bus Station3:00 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/7/2025 12:10:00 AM to North Station, Brussels (Belgium) arriving at 12/8/2025 3:00:00 AM. 50 Economy ticket for $106 per person are available. Travel duration is 26h 50m
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FlixBus32h 25m010:55 PMRomeTiburtina Bus Station7:20 AMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/7/2025 10:55:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 12/9/2025 7:20:00 AM. 50 Economy ticket for $102 per person are available. Travel duration is 32h 25m
Fastest Flights Sunday
Fastest Buses Sunday
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Ryanair6h 35m01:00 PMRome Fiumicino AirportRome Fiumicino Airport7:35 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Ryanair goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/8/2025 1:00:00 PM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/8/2025 7:35:00 PM. 50 Economy ticket for $560 per person are available. Travel duration is 6h 35m
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LC Perú7h 5m06:40 AMRome Fiumicino AirportRome Fiumicino Airport1:45 PMAntwerp AirportAntwerp Airport0EconomyA Flight from LC Perú goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/8/2025 6:40:00 AM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/8/2025 1:45:00 PM. 50 Economy ticket for $176 per person are available. Travel duration is 7h 5m
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Skyscanner7h 35m06:10 AMRome Fiumicino AirportRome Fiumicino Airport1:45 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Skyscanner goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/8/2025 6:10:00 AM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/8/2025 1:45:00 PM. 50 Economy ticket for $410 per person are available. Travel duration is 7h 35m
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LC Perú7h 40m011:55 AMRome Fiumicino AirportRome Fiumicino Airport7:35 PMAntwerp AirportAntwerp Airport0EconomyA Flight from LC Perú goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/8/2025 11:55:00 AM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/8/2025 7:35:00 PM. 50 Economy ticket for $410 per person are available. Travel duration is 7h 40m
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FlixBus23h 15m09:25 AMRomeTiburtina Bus Station8:40 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/8/2025 9:25:00 AM to North Station, Brussels (Belgium) arriving at 12/9/2025 8:40:00 AM. 50 Economy ticket for $127 per person are available. Travel duration is 23h 15m
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FlixBus27h 25m012:10 AMRomeTiburtina Bus Station3:35 AMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/8/2025 12:10:00 AM to North Station, Brussels (Belgium) arriving at 12/9/2025 3:35:00 AM. 50 Economy ticket for $109 per person are available. Travel duration is 27h 25m
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FlixBus29h 10m01:05 PMRomeAnagnina Bus Station6:15 PMBrusselsNorth Station0EconomyA Bus from FlixBus goes from Anagnina Bus Station, Rome (Italy) at 12/8/2025 1:05:00 PM to North Station, Brussels (Belgium) arriving at 12/9/2025 6:15:00 PM. 50 Economy ticket for $121 per person are available. Travel duration is 29h 10m
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FlixBus32h 5m012:10 AMRomeTiburtina Bus Station8:15 AMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/8/2025 12:10:00 AM to Midi Bus Station, Brussels (Belgium) arriving at 12/9/2025 8:15:00 AM. 50 Economy ticket for $109 per person are available. Travel duration is 32h 5m
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FlixBus33h 30m010:45 PMRomeTiburtina Bus Station8:15 AMBrusselsMidi Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/8/2025 10:45:00 PM to Midi Bus Station, Brussels (Belgium) arriving at 12/10/2025 8:15:00 AM. 50 Economy ticket for $111 per person are available. Travel duration is 33h 30m
Fastest Flights Monday
Fastest Buses Monday
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ITA Airways16h 20m09:25 PMRome Fiumicino AirportRome Fiumicino Airport1:45 PMAntwerp AirportAntwerp Airport0EconomyA Flight from ITA Airways goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/10/2025 9:25:00 PM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/11/2025 1:45:00 PM. 50 Economy ticket for $204 per person are available. Travel duration is 16h 20m
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Ryanair17h 15m08:30 PMRome Fiumicino AirportRome Fiumicino Airport1:45 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Ryanair goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/10/2025 8:30:00 PM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/11/2025 1:45:00 PM. 50 Economy ticket for $198 per person are available. Travel duration is 17h 15m
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Vueling Airlines18h 15m07:30 PMRome Fiumicino AirportRome Fiumicino Airport1:45 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Vueling Airlines goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/10/2025 7:30:00 PM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/11/2025 1:45:00 PM. 50 Economy ticket for $176 per person are available. Travel duration is 18h 15m
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Aeronova19h 20m06:25 PMRome Fiumicino AirportRome Fiumicino Airport1:45 PMAntwerp AirportAntwerp Airport0EconomyA Flight from Aeronova goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/10/2025 6:25:00 PM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/11/2025 1:45:00 PM. 50 Economy ticket for $184 per person are available. Travel duration is 19h 20m
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LC Perú31h 5m06:40 AMRome Fiumicino AirportRome Fiumicino Airport1:45 PMAntwerp AirportAntwerp Airport0EconomyA Flight from LC Perú goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 12/10/2025 6:40:00 AM to Antwerp Airport, Antwerp Airport (Belgium) arriving at 12/11/2025 1:45:00 PM. 50 Economy ticket for $144 per person are available. Travel duration is 31h 5m
Fastest Flights Wednesday
Here you will find all operators and timetables for a
Bus from Rome to Brussels
What are the most popular stations in Rome and Brussels?
In Rome, you will usually depart from Termini Bus Station, Termini Central Station or Ostiense Train Station, while in Brussels you will be arriving at Midi Bus Station, North Station or Gare Centrale, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Brussels from Rome? With 9 connections between 1 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Rome and Brussels, you can pay as low as $85 with a Flight from Wizz Air.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from Ryanair: you will get to Brussels in just 2h 10m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Rome and Brussels are FlixBus, LC Perú and Ryanair, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Rome and Brussels is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Settebagni or to Saint-Gilles, and look at flights from Rome Ciampino Airport, and landing at Brussels South Charleroi Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Rome to Brussels?
The most popular companies between Rome and Brussels, are FlixBus, LC Perú and Ryanair. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus
Airlines: LC Perú, Ryanair, Skyscanner and 6 more.
All you need to know when you travel from Rome to Brussels
Check all information on comfort and services on all modes of transports from Rome to Brussels. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Rome to Brussels
How can I reach Brussels from Rome?
Every day, there are on average 9 connections between Bus and Flight, with which you can get to Brussels from Rome.
How far is Brussels from Rome?
The distance between Rome and Brussels is 729.4 miles.
What is the most ecofriendly mode of transport between Rome and Brussels?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 32 kgs of CO2, a train 41 kgs, a car 200 kgs, and a flight 289 kgs.
What is the cheapest mode of transport from Rome to Brussels?
You can get to Brussels with just $85 by taking a Flight from Wizz Air.
What is the fastest way to get from Rome to Brussels?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Brussels in just 2h 10m with a Flight from Ryanair.
More routes to Rome and to Brussels
Looking for more options? Here you can see the most popular routes to Rome and to Brussels. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Rome
- Avellino to Rome
- Bari to Rome
- Battipaglia to Rome
- Caserta to Rome
- Catanzaro to Rome
- Chieti to Rome
- Civitanova to Rome
- Foggia to Rome
- Genoa to Rome
- L'Aquila to Rome
- Lamezia Terme to Rome
- Lecce to Rome
- Milan to Rome
- Mosciano Sant'Angelo to Rome
- Naples to Rome
- Palermo to Rome
- Perugia to Rome
- Pescara to Rome
- Potenza to Rome
- Rome Fiumicino Airport to Rome
- Sala Consilina to Rome
- Salerno to Rome
- San Benedetto del Tronto to Rome
- Venice to Rome
- Trips to Brussels
- Barcelona to Brussels
- Basel to Brussels
- Beauvais to Brussels
- Berlin to Brussels
- Birmingham to Brussels
- Bordeaux to Brussels
- Dusseldorf to Brussels
- Edinburgh to Brussels
- Eindhoven to Brussels
- Frankfurt am Main to Brussels
- Hamburg to Brussels
- Le Mans to Brussels
- Leeds to Brussels
- Leipzig to Brussels
- Lille to Brussels
- Linz to Brussels
- Lyon to Brussels
- Madrid to Brussels
- Manchester to Brussels
- Nantes to Brussels
- Newcastle upon Tyne to Brussels
- Paris Charles de Gaulle Airport to Brussels
- The Hague to Brussels
- Toulouse to Brussels

