What is the best way to travel from Rome to Isernia?
Looking for a trip? Compare all the available Carpool and Buses for the journey to Isernia from Rome. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
What is the cheapest way to reach Isernia from Rome?
You can get to Isernia with just $6 by taking a Bus from MarinoBus, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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MarinoBus2h 30m04:30 PMRomeTiburtina Bus Station7:00 PMIserniaCentral Bus Station0EconomyA Bus from MarinoBus goes from Tiburtina Bus Station, Rome (Italy) at 11/4/2026 4:30:00 PM to Central Bus Station, Isernia (Italy) arriving at 11/4/2026 7:00:00 PM. 50 Economy ticket for $10 per person are available. Travel duration is 2h 30m
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FlixBus2h 25m02:50 PMRomeTiburtina Bus Station5:15 PMIserniaCentral Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 11/4/2026 2:50:00 PM to Central Bus Station, Isernia (Italy) arriving at 11/4/2026 5:15:00 PM. 50 Economy ticket for $15 per person are available. Travel duration is 2h 25m
Cheapest Buses Wednesday
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MarinoBus2h 30m04:30 PMRomeTiburtina Bus Station7:00 PMIserniaCentral Bus Station0EconomyA Bus from MarinoBus goes from Tiburtina Bus Station, Rome (Italy) at 11/5/2026 4:30:00 PM to Central Bus Station, Isernia (Italy) arriving at 11/5/2026 7:00:00 PM. 50 Economy ticket for $6 per person are available. Travel duration is 2h 30m
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FlixBus9h 14m08:50 AMRome Fiumicino AirportRome Fiumicino Airport6:04 PMIserniaCentral Bus Station0EconomyA Bus from FlixBus goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 11/5/2026 8:50:00 AM to Central Bus Station, Isernia (Italy) arriving at 11/5/2026 6:04:00 PM. 50 Economy ticket for $37 per person are available. Travel duration is 9h 14m
Cheapest Buses Thursday
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FlixBus2h 25m02:50 PMRomeTiburtina Bus Station5:15 PMIserniaCentral Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 11/6/2026 2:50:00 PM to Central Bus Station, Isernia (Italy) arriving at 11/6/2026 5:15:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 2h 25m
Cheapest Buses Friday
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FlixBus2h 25m02:50 PMRomeTiburtina Bus Station5:15 PMIserniaCentral Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 11/7/2026 2:50:00 PM to Central Bus Station, Isernia (Italy) arriving at 11/7/2026 5:15:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 2h 25m
Cheapest Buses Saturday
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MarinoBus2h 30m04:30 PMRomeTiburtina Bus Station7:00 PMIserniaCentral Bus Station0EconomyA Bus from MarinoBus goes from Tiburtina Bus Station, Rome (Italy) at 11/8/2026 4:30:00 PM to Central Bus Station, Isernia (Italy) arriving at 11/8/2026 7:00:00 PM. 50 Economy ticket for $6 per person are available. Travel duration is 2h 30m
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BlaBlaCar2h 20m07:00 PMRome9:20 PMIsernia0EconomyA Car from BlaBlaCar goes from , Rome (Italy) at 11/8/2026 7:00:00 PM to , Isernia (Italy) arriving at 11/8/2026 9:20:00 PM. 50 Economy ticket for $20 per person are available. Travel duration is 2h 20m
Cheapest Buses Sunday
Cheapest Carpool Sunday
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FlixBus7h 30m04:05 AMRome Fiumicino AirportRome Fiumicino Airport11:35 AMIserniaCentral Bus Station0EconomyA Bus from FlixBus goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 11/9/2026 4:05:00 AM to Central Bus Station, Isernia (Italy) arriving at 11/9/2026 11:35:00 AM. 50 Economy ticket for $29 per person are available. Travel duration is 7h 30m
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FlixBus9h 30m08:50 AMRome Fiumicino AirportRome Fiumicino Airport6:20 PMIserniaCentral Bus Station0EconomyA Bus from FlixBus goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 11/9/2026 8:50:00 AM to Central Bus Station, Isernia (Italy) arriving at 11/9/2026 6:20:00 PM. 50 Economy ticket for $36 per person are available. Travel duration is 9h 30m
Cheapest Buses Monday
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FlixBus2h 25m02:50 PMRomeTiburtina Bus Station5:15 PMIserniaCentral Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 11/10/2026 2:50:00 PM to Central Bus Station, Isernia (Italy) arriving at 11/10/2026 5:15:00 PM. 50 Economy ticket for $12 per person are available. Travel duration is 2h 25m
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FlixBus7h 4m04:40 AMRome Ciampino AirportRome Ciampino Airport11:44 AMIserniaCentral Bus Station0EconomyA Bus from FlixBus goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 11/10/2026 4:40:00 AM to Central Bus Station, Isernia (Italy) arriving at 11/10/2026 11:44:00 AM. 50 Economy ticket for $24 per person are available. Travel duration is 7h 4m
Cheapest Buses Tuesday
What are the fastest trips from Rome to Isernia?
You can get to Isernia from Rome in just 2h 20m with a Carpool from BlaBlaCar. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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FlixBus2h 25m02:50 PMRomeTiburtina Bus Station5:15 PMIserniaCentral Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 11/4/2026 2:50:00 PM to Central Bus Station, Isernia (Italy) arriving at 11/4/2026 5:15:00 PM. 50 Economy ticket for $15 per person are available. Travel duration is 2h 25m
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MarinoBus2h 30m04:30 PMRomeTiburtina Bus Station7:00 PMIserniaCentral Bus Station0EconomyA Bus from MarinoBus goes from Tiburtina Bus Station, Rome (Italy) at 11/4/2026 4:30:00 PM to Central Bus Station, Isernia (Italy) arriving at 11/4/2026 7:00:00 PM. 50 Economy ticket for $10 per person are available. Travel duration is 2h 30m
Fastest Buses Wednesday
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MarinoBus2h 30m04:30 PMRomeTiburtina Bus Station7:00 PMIserniaCentral Bus Station0EconomyA Bus from MarinoBus goes from Tiburtina Bus Station, Rome (Italy) at 11/5/2026 4:30:00 PM to Central Bus Station, Isernia (Italy) arriving at 11/5/2026 7:00:00 PM. 50 Economy ticket for $6 per person are available. Travel duration is 2h 30m
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FlixBus9h 14m08:50 AMRome Fiumicino AirportRome Fiumicino Airport6:04 PMIserniaCentral Bus Station0EconomyA Bus from FlixBus goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 11/5/2026 8:50:00 AM to Central Bus Station, Isernia (Italy) arriving at 11/5/2026 6:04:00 PM. 50 Economy ticket for $37 per person are available. Travel duration is 9h 14m
Fastest Buses Thursday
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FlixBus2h 25m02:50 PMRomeTiburtina Bus Station5:15 PMIserniaCentral Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 11/6/2026 2:50:00 PM to Central Bus Station, Isernia (Italy) arriving at 11/6/2026 5:15:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 2h 25m
Fastest Buses Friday
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FlixBus2h 25m02:50 PMRomeTiburtina Bus Station5:15 PMIserniaCentral Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 11/7/2026 2:50:00 PM to Central Bus Station, Isernia (Italy) arriving at 11/7/2026 5:15:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 2h 25m
Fastest Buses Saturday
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BlaBlaCar2h 20m07:00 PMRome9:20 PMIsernia0EconomyA Car from BlaBlaCar goes from , Rome (Italy) at 11/8/2026 7:00:00 PM to , Isernia (Italy) arriving at 11/8/2026 9:20:00 PM. 50 Economy ticket for $20 per person are available. Travel duration is 2h 20m
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MarinoBus2h 30m04:30 PMRomeTiburtina Bus Station7:00 PMIserniaCentral Bus Station0EconomyA Bus from MarinoBus goes from Tiburtina Bus Station, Rome (Italy) at 11/8/2026 4:30:00 PM to Central Bus Station, Isernia (Italy) arriving at 11/8/2026 7:00:00 PM. 50 Economy ticket for $6 per person are available. Travel duration is 2h 30m
Fastest Carpool Sunday
Fastest Buses Sunday
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FlixBus7h 30m04:05 AMRome Fiumicino AirportRome Fiumicino Airport11:35 AMIserniaCentral Bus Station0EconomyA Bus from FlixBus goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 11/9/2026 4:05:00 AM to Central Bus Station, Isernia (Italy) arriving at 11/9/2026 11:35:00 AM. 50 Economy ticket for $29 per person are available. Travel duration is 7h 30m
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FlixBus9h 30m08:50 AMRome Fiumicino AirportRome Fiumicino Airport6:20 PMIserniaCentral Bus Station0EconomyA Bus from FlixBus goes from Rome Fiumicino Airport, Rome Fiumicino Airport (Italy) at 11/9/2026 8:50:00 AM to Central Bus Station, Isernia (Italy) arriving at 11/9/2026 6:20:00 PM. 50 Economy ticket for $36 per person are available. Travel duration is 9h 30m
Fastest Buses Monday
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FlixBus2h 25m02:50 PMRomeTiburtina Bus Station5:15 PMIserniaCentral Bus Station0EconomyA Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 11/10/2026 2:50:00 PM to Central Bus Station, Isernia (Italy) arriving at 11/10/2026 5:15:00 PM. 50 Economy ticket for $12 per person are available. Travel duration is 2h 25m
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FlixBus7h 4m04:40 AMRome Ciampino AirportRome Ciampino Airport11:44 AMIserniaCentral Bus Station0EconomyA Bus from FlixBus goes from Rome Ciampino Airport, Rome Ciampino Airport (Italy) at 11/10/2026 4:40:00 AM to Central Bus Station, Isernia (Italy) arriving at 11/10/2026 11:44:00 AM. 50 Economy ticket for $24 per person are available. Travel duration is 7h 4m
Fastest Buses Tuesday
Here you will find all operators and timetables for a
Bus from Rome to Isernia
What are the most popular stations in Rome and Isernia?
In Rome, you will usually depart from Termini Bus Station, Tiburtina Train Station or Tiburtina Bus Station, while in Isernia you will be arriving at Central Bus Station or Train Station, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Isernia from Rome? With 1 connections between 2 Carpool and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Rome and Isernia, you can pay as low as $6 with a Bus from MarinoBus.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Carpool from BlaBlaCar: you will get to Isernia in just 2h 20m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Rome and Isernia are FlixBus, MarinoBus and BlaBlaCar, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Rome and Isernia is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Settebagni or to Carpinone, and look at flights from Rome Ciampino Airport, and landing at . Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Rome to Isernia?
The most popular companies between Rome and Isernia, are FlixBus, MarinoBus and BlaBlaCar. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus and MarinoBus
All you need to know when you travel from Rome to Isernia
Check all information on comfort and services on all modes of transports from Rome to Isernia. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Rome to Isernia
How can I reach Isernia from Rome?
Every day, there are on average 1 connections between Carpool and Bus, with which you can get to Isernia from Rome.
How far is Isernia from Rome?
The distance between Rome and Isernia is 91.9 miles.
What is the most ecofriendly mode of transport between Rome and Isernia?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 4 kgs of CO2, a train 5 kgs, a car 25 kgs, and a flight 36 kgs.
What is the cheapest mode of transport from Rome to Isernia?
You can get to Isernia with just $6 by taking a Bus from MarinoBus.
What is the fastest way to get from Rome to Isernia?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Isernia in just 2h 20m with a Carpool from BlaBlaCar.
More routes to Rome and to Isernia
Looking for more options? Here you can see the most popular routes to Rome and to Isernia. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Rome
- Avellino to Rome
- Bari to Rome
- Battipaglia to Rome
- Bologna to Rome
- Catania to Rome
- Cesena to Rome
- Chieti to Rome
- Civitanova to Rome
- Civitavecchia to Rome
- Cosenza to Rome
- Deruta to Rome
- L'Aquila to Rome
- Lecce to Rome
- Milan to Rome
- Naples to Rome
- Perugia to Rome
- Pescara to Rome
- Pisa to Rome
- Potenza to Rome
- Rome Fiumicino Airport to Rome
- Sala Consilina to Rome
- Salerno to Rome
- San Benedetto del Tronto to Rome
- Teramo to Rome
- Trips to Isernia
- Chieti to Isernia
- Naples to Isernia
- San Salvo Marina to Isernia
