Bus Rome to Isernia: Compare prices and save money

Compare all timetables for the bus from Rome to Isernia

Here is a selection of the cheapest bus trips from the schedule from Rome to Isernia from various bus operators like FlixBus for the next days.

today

tomorrow

Saturday

$30

Sunday

Monday

Tuesday

Wednesday

Cheapest bus trips Saturday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	6h 14m	5:10 AM	Rome	Tiburtina Bus Station	11:24 AM	Isernia	Central Bus Station		Economy	$30	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 12/6/2025 5:10:00 AM to Central Bus Station, Isernia (Italy) arriving at 12/6/2025 11:24:00 AM. 50 Economy ticket for $30 per person are available. Travel duration is 6h 14m

Did you know that if you travel from Rome to Isernia via Caserta, you can save more than $10? You can find the corresponding connections below.
- Distribusion
  
  5h 54m
  
  0
  
  5:30 AM
  
  Rome
  Tiburtina Bus Station
  
  8:05 AM
  
  Caserta
  Train Station
  
  0
  
  Premium Economy
  
  $9
  
  A Bus from Distribusion goes from Tiburtina Bus Station, Rome (Italy) at 12/8/2025 5:30:00 AM to Train Station, Caserta (Italy) arriving at 12/8/2025 8:05:00 AM. 50 Premium Economy ticket for $9 per person are available. Travel duration is 2h 35m
- FlixBus
  
  1h 14m
  
  0
  
  10:10 AM
  
  Caserta
  Train Station
  
  11:24 AM
  
  Isernia
  Central Bus Station
  
  0
  
  Economy
  
  $10
  
  A Bus from FlixBus goes from Train Station, Caserta (Italy) at 12/8/2025 10:10:00 AM to Central Bus Station, Isernia (Italy) arriving at 12/8/2025 11:24:00 AM. 50 Economy ticket for $10 per person are available. Travel duration is 1h 14m
Travel Time is 0h 20m shorter, and you will save $10

Best Price Offer: The price for the cheapest bus from Rome to Isernia is $30 on 12/6/2025. Flexible travelers save on ticket prices.

Facts about the bus from Rome to Isernia

Compare all providers like FlixBus that travel 1 times every day by bus from Rome to Isernia in one click! Book your bus ticket from Rome to Isernia starting from $30!

Cheapest Bus	$30
Fastest Bus	6h 14m
Earliest Bus	5:10 AM
Latest Bus	5:10 AM
Daily Bus Routes	1 Ø
Distance	91.9 miles
Bus Companies	FlixBus

Cheapest bus connections from Rome to Isernia

Every day, 1 buses from 1 bus companies leave Rome for Isernia: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/04/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 11/30

Monday 12/01

Tuesday 12/02

Wednesday 12/03

Thursday 12/04

Friday 12/05

Saturday 12/06

$30

Sunday 12/07

Monday 12/08

Tuesday 12/09

Wednesday 12/10

Thursday 12/11

Friday 12/12

Saturday 12/13

Sunday 12/14

Monday 12/15

Tuesday 12/16

Wednesday 12/17

Thursday 12/18

Friday 12/19

Saturday 12/20

Sunday 12/21

Monday 12/22

Tuesday 12/23

Wednesday 12/24

Thursday 12/25

Friday 12/26

Saturday 12/27

How to save money travelling from Rome to Isernia

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Rome to Isernia in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Rome to Isernia, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Rome to Isernia are also emptier.

Beloved bus companies from Rome to Isernia

These are the most booked bus companies between Rome to Isernia from our users.

FlixBus from Rome to Isernia

Here you will find the key facts about the FlixBus bus route Rome to Isernia:

Cheapest Price	$30
Fastest Bus	6h 14m
Earliest Bus	5:10 AM
Last Bus	5:10 AM
Daily Connections	1 Ø
Found on	11/27/2025

All bus stations and stops in Rome and Isernia

In the map below, you can see where to find all bus stations in Rome and Isernia.

Anagnina Bus Station

Piazzale della Stazione Anagnina

Termini Bus Station

Piazza dei Cinquecento 64

Tiburtina Bus Station

Tiburtina Partenze

Vatican City

Via Crescenzio 19

Central Bus Station

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Rome to Isernia? Compare all modes of transports from Rome to Isernia.

Service and Comfort on the bus from Rome to Isernia

Want to know which seat classes are available on the buses from Rome to Isernia? Or which bus companies serve the route Rome to Isernia? Below you will find answers to your questions.

FAQs about the Rome to Isernia bus

How much does a Rome Isernia bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $30 and takes 6h 14m to reach Isernia. Compare offers to save money!

How much could I save by comparing buses from Rome to Isernia?

This route is offered by 1 companies with a range of ticket prices between $30 and $30. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Isernia.

On average, how many connections are available from Rome to Isernia each day?

Every day, the Rome to Isernia bus route is served by approximately 1 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Rome to Isernia take?

The fastest bus from Rome to Isernia is offered by FlixBus and takes 6h 14m. Bus tickets for this connection cost $30. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Rome to Isernia?

The earliest bus arriving in Isernia from Rome starts at 5:10 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Rome to Isernia?

The latest bus trip departing from Rome for Isernia starts at 5:10 AM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Rome Isernia route?

When traveling by bus from Rome to Isernia, passengers can travel with FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Rome and Isernia?

You can check all the direct connections between Rome and Isernia by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus.

What can I take with me on the Rome to Isernia bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Rome Isernia bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Rome Isernia bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Rome to Isernia on your planned travel date.

Available seat classes which are offered on the bus route Rome to Isernia

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Rome and to Isernia

Here’s an overview of the most popular bus routes to Rome and to Isernia. Simply click on the connection of your choice, and you will find all the details about your bus route!