What is the best way to travel from Siena to Rome?
Looking for a trip? Compare all the available Carpool, Trains and Buses for the journey to Rome from Siena. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 6 available companies to find your perfect trip!
What is the cheapest way to reach Rome from Siena?
You can get to Rome with just $6 by taking a Bus from Itabus, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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FlixBus2h 40m08:45 AMSienaTrain Station11:25 AMRomeTiburtina Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 10/4/2026 8:45:00 AM to Tiburtina Bus Station, Rome (Italy) arriving at 10/4/2026 11:25:00 AM. 50 Economy ticket for $8 per person are available. Travel duration is 2h 40m
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Itabus2h 50m09:25 AMSienaPiazza Antonio Gramsci12:15 PMRomeTiburtina Bus Station0EconomyA Bus from Itabus goes from Piazza Antonio Gramsci, Siena (Italy) at 10/4/2026 9:25:00 AM to Tiburtina Bus Station, Rome (Italy) arriving at 10/4/2026 12:15:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 2h 50m
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Busitalia Rail Service2h 50m08:40 PMSienaCentral Bus Station11:30 PMRomeTiburtina Bus Station0EconomyA Bus from Busitalia Rail Service goes from Central Bus Station, Siena (Italy) at 10/4/2026 8:40:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 10/4/2026 11:30:00 PM. 50 Economy ticket for $12 per person are available. Travel duration is 2h 50m
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Busitalia Fast3h 0m08:30 PMSienaPiazza Antonio Gramsci11:30 PMRomeTiburtina Bus Station0EconomyA Bus from Busitalia Fast goes from Piazza Antonio Gramsci, Siena (Italy) at 10/4/2026 8:30:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 10/4/2026 11:30:00 PM. 50 Economy ticket for $12 per person are available. Travel duration is 3h 0m
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Trenitalia4h 49m06:00 AMSienaTrain Station10:49 AMRomeTiburtina Train Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 10/4/2026 6:00:00 AM to Tiburtina Train Station, Rome (Italy) arriving at 10/4/2026 10:49:00 AM. 50 Economy ticket for $24 per person are available. Travel duration is 4h 49m
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Trenitalia5h 58m010:02 AMSienaTrain Station4:00 PMRomeTiburtina Train Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 10/4/2026 10:02:00 AM to Tiburtina Train Station, Rome (Italy) arriving at 10/4/2026 4:00:00 PM. 50 Economy ticket for $24 per person are available. Travel duration is 5h 58m
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Trenitalia5h 3m08:02 AMSienaTrain Station1:05 PMRomeTermini Central Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 10/4/2026 8:02:00 AM to Termini Central Station, Rome (Italy) arriving at 10/4/2026 1:05:00 PM. 50 Economy ticket for $24 per person are available. Travel duration is 5h 3m
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Trenitalia5h 43m02:02 PMSienaTrain Station7:45 PMRomeTermini Central Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 10/4/2026 2:02:00 PM to Termini Central Station, Rome (Italy) arriving at 10/4/2026 7:45:00 PM. 50 Economy ticket for $24 per person are available. Travel duration is 5h 43m
Cheapest Buses Sunday
Cheapest Trains Sunday
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FlixBus2h 55m07:00 AMSienaTrain Station9:55 AMRomeTiburtina Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 10/5/2026 7:00:00 AM to Tiburtina Bus Station, Rome (Italy) arriving at 10/5/2026 9:55:00 AM. 50 Economy ticket for $7 per person are available. Travel duration is 2h 55m
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Itabus2h 50m09:25 AMSienaTrain Station12:15 PMRomeTiburtina Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 10/5/2026 9:25:00 AM to Tiburtina Bus Station, Rome (Italy) arriving at 10/5/2026 12:15:00 PM. 50 Premium Economy ticket for $8 per person are available. Travel duration is 2h 50m
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Busitalia Rail Service2h 50m08:40 PMSienaCentral Bus Station11:30 PMRomeTiburtina Bus Station0EconomyA Bus from Busitalia Rail Service goes from Central Bus Station, Siena (Italy) at 10/5/2026 8:40:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 10/5/2026 11:30:00 PM. 50 Economy ticket for $12 per person are available. Travel duration is 2h 50m
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Busitalia Fast2h 50m08:40 PMSienaTrain Station11:30 PMRomeTiburtina Bus Station0EconomyA Bus from Busitalia Fast goes from Train Station, Siena (Italy) at 10/5/2026 8:40:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 10/5/2026 11:30:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 2h 50m
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Trenitalia4h 52m08:13 AMSienaTrain Station1:05 PMRomeTermini Central Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 10/5/2026 8:13:00 AM to Termini Central Station, Rome (Italy) arriving at 10/5/2026 1:05:00 PM. 50 Economy ticket for $24 per person are available. Travel duration is 4h 52m
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Trenitalia3h 40m01:25 PMSienaTrain Station5:05 PMRomeTermini Central Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 10/5/2026 1:25:00 PM to Termini Central Station, Rome (Italy) arriving at 10/5/2026 5:05:00 PM. 50 Economy ticket for $24 per person are available. Travel duration is 3h 40m
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Trenitalia5h 2m02:43 PMSienaTrain Station7:45 PMRomeTermini Central Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 10/5/2026 2:43:00 PM to Termini Central Station, Rome (Italy) arriving at 10/5/2026 7:45:00 PM. 50 Economy ticket for $24 per person are available. Travel duration is 5h 2m
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Trenitalia4h 53m04:02 PMSienaTrain Station8:55 PMRomeTermini Central Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 10/5/2026 4:02:00 PM to Termini Central Station, Rome (Italy) arriving at 10/5/2026 8:55:00 PM. 50 Economy ticket for $24 per person are available. Travel duration is 4h 53m
Cheapest Buses Monday
Cheapest Trains Monday
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Itabus2h 50m01:45 PMSienaPiazza Antonio Gramsci4:35 PMRomeTiburtina Bus Station0EconomyA Bus from Itabus goes from Piazza Antonio Gramsci, Siena (Italy) at 10/6/2026 1:45:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 10/6/2026 4:35:00 PM. 50 Economy ticket for $6 per person are available. Travel duration is 2h 50m
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FlixBus3h 5m05:35 AMSienaTrain Station8:40 AMRomeTiburtina Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 10/6/2026 5:35:00 AM to Tiburtina Bus Station, Rome (Italy) arriving at 10/6/2026 8:40:00 AM. 50 Economy ticket for $7 per person are available. Travel duration is 3h 5m
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Busitalia Rail Service2h 50m08:40 PMSienaCentral Bus Station11:30 PMRomeTiburtina Bus Station0EconomyA Bus from Busitalia Rail Service goes from Central Bus Station, Siena (Italy) at 10/6/2026 8:40:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 10/6/2026 11:30:00 PM. 50 Economy ticket for $12 per person are available. Travel duration is 2h 50m
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Busitalia Fast2h 50m08:40 PMSienaTrain Station11:30 PMRomeTiburtina Bus Station0EconomyA Bus from Busitalia Fast goes from Train Station, Siena (Italy) at 10/6/2026 8:40:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 10/6/2026 11:30:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 2h 50m
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Trenitalia4h 19m04:48 PMSienaTrain Station9:07 PMRomeTiburtina Train Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 10/6/2026 4:48:00 PM to Tiburtina Train Station, Rome (Italy) arriving at 10/6/2026 9:07:00 PM. 50 Economy ticket for $22 per person are available. Travel duration is 4h 19m
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Trenitalia4h 47m08:13 AMSienaTrain Station1:00 PMRomeTermini Central Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 10/6/2026 8:13:00 AM to Termini Central Station, Rome (Italy) arriving at 10/6/2026 1:00:00 PM. 50 Economy ticket for $23 per person are available. Travel duration is 4h 47m
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Trenitalia3h 40m01:25 PMSienaTrain Station5:05 PMRomeTermini Central Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 10/6/2026 1:25:00 PM to Termini Central Station, Rome (Italy) arriving at 10/6/2026 5:05:00 PM. 50 Economy ticket for $23 per person are available. Travel duration is 3h 40m
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Trenitalia5h 2m02:43 PMSienaTrain Station7:45 PMRomeTermini Central Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 10/6/2026 2:43:00 PM to Termini Central Station, Rome (Italy) arriving at 10/6/2026 7:45:00 PM. 50 Economy ticket for $23 per person are available. Travel duration is 5h 2m
Cheapest Buses Tuesday
Cheapest Trains Tuesday
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Itabus2h 50m01:45 PMSienaTrain Station4:35 PMRomeTiburtina Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 10/7/2026 1:45:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 10/7/2026 4:35:00 PM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 2h 50m
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Itabus2h 50m04:25 PMSienaTrain Station7:15 PMRomeTiburtina Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 10/7/2026 4:25:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 10/7/2026 7:15:00 PM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 2h 50m
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Busitalia Rail Service2h 50m08:40 PMSienaCentral Bus Station11:30 PMRomeTiburtina Bus Station0EconomyA Bus from Busitalia Rail Service goes from Central Bus Station, Siena (Italy) at 10/7/2026 8:40:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 10/7/2026 11:30:00 PM. 50 Economy ticket for $12 per person are available. Travel duration is 2h 50m
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Busitalia Rail Service3h 0m08:30 PMSienaPiazza Antonio Gramsci11:30 PMRomeTiburtina Bus Station0EconomyA Bus from Busitalia Rail Service goes from Piazza Antonio Gramsci, Siena (Italy) at 10/7/2026 8:30:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 10/7/2026 11:30:00 PM. 50 Economy ticket for $12 per person are available. Travel duration is 3h 0m
Cheapest Buses Wednesday
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Busitalia Rail Service2h 50m08:40 PMSienaPiazza Antonio Gramsci11:30 PMRomeTiburtina Bus Station0EconomyA Bus from Busitalia Rail Service goes from Piazza Antonio Gramsci, Siena (Italy) at 10/8/2026 8:40:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 10/8/2026 11:30:00 PM. 50 Economy ticket for $12 per person are available. Travel duration is 2h 50m
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Busitalia Rail Service2h 40m08:50 PMSienaBus Stop11:30 PMRomeTiburtina Bus Station0EconomyA Bus from Busitalia Rail Service goes from Bus Stop, Siena (Italy) at 10/8/2026 8:50:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 10/8/2026 11:30:00 PM. 50 Economy ticket for $12 per person are available. Travel duration is 2h 40m
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Itabus2h 55m05:15 AMSienaPiazza Antonio Gramsci8:10 AMRomeTiburtina Bus Station0EconomyA Bus from Itabus goes from Piazza Antonio Gramsci, Siena (Italy) at 10/8/2026 5:15:00 AM to Tiburtina Bus Station, Rome (Italy) arriving at 10/8/2026 8:10:00 AM. 50 Economy ticket for $13 per person are available. Travel duration is 2h 55m
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Itabus2h 50m01:45 PMSienaPiazza Antonio Gramsci4:35 PMRomeTiburtina Bus Station0EconomyA Bus from Itabus goes from Piazza Antonio Gramsci, Siena (Italy) at 10/8/2026 1:45:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 10/8/2026 4:35:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 2h 50m
Cheapest Buses Thursday
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FlixBus3h 5m05:35 AMSienaTrain Station8:40 AMRomeTiburtina Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 10/9/2026 5:35:00 AM to Tiburtina Bus Station, Rome (Italy) arriving at 10/9/2026 8:40:00 AM. 50 Economy ticket for $7 per person are available. Travel duration is 3h 5m
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Busitalia Rail Service2h 50m08:40 PMSienaCentral Bus Station11:30 PMRomeTiburtina Bus Station0EconomyA Bus from Busitalia Rail Service goes from Central Bus Station, Siena (Italy) at 10/9/2026 8:40:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 10/9/2026 11:30:00 PM. 50 Economy ticket for $12 per person are available. Travel duration is 2h 50m
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Busitalia Fast3h 0m08:30 PMSienaPiazza Antonio Gramsci11:30 PMRomeTiburtina Bus Station0EconomyA Bus from Busitalia Fast goes from Piazza Antonio Gramsci, Siena (Italy) at 10/9/2026 8:30:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 10/9/2026 11:30:00 PM. 50 Economy ticket for $12 per person are available. Travel duration is 3h 0m
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Itabus2h 50m09:25 AMSienaCentral Bus Station12:15 PMRomeTiburtina Bus Station0EconomyA Bus from Itabus goes from Central Bus Station, Siena (Italy) at 10/9/2026 9:25:00 AM to Tiburtina Bus Station, Rome (Italy) arriving at 10/9/2026 12:15:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 2h 50m
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Trenitalia4h 52m08:13 AMSienaTrain Station1:05 PMRomeTermini Central Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 10/9/2026 8:13:00 AM to Termini Central Station, Rome (Italy) arriving at 10/9/2026 1:05:00 PM. 50 Economy ticket for $24 per person are available. Travel duration is 4h 52m
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Trenitalia3h 40m01:25 PMSienaTrain Station5:05 PMRomeTermini Central Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 10/9/2026 1:25:00 PM to Termini Central Station, Rome (Italy) arriving at 10/9/2026 5:05:00 PM. 50 Economy ticket for $24 per person are available. Travel duration is 3h 40m
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Trenitalia5h 2m02:43 PMSienaTrain Station7:45 PMRomeTermini Central Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 10/9/2026 2:43:00 PM to Termini Central Station, Rome (Italy) arriving at 10/9/2026 7:45:00 PM. 50 Economy ticket for $24 per person are available. Travel duration is 5h 2m
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Trenitalia4h 53m04:02 PMSienaTrain Station8:55 PMRomeTermini Central Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 10/9/2026 4:02:00 PM to Termini Central Station, Rome (Italy) arriving at 10/9/2026 8:55:00 PM. 50 Economy ticket for $24 per person are available. Travel duration is 4h 53m
Cheapest Buses Friday
Cheapest Trains Friday
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FlixBus3h 5m05:35 AMSienaTrain Station8:40 AMRomeTiburtina Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 10/10/2026 5:35:00 AM to Tiburtina Bus Station, Rome (Italy) arriving at 10/10/2026 8:40:00 AM. 50 Economy ticket for $7 per person are available. Travel duration is 3h 5m
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Busitalia Rail Service2h 50m08:40 PMSienaCentral Bus Station11:30 PMRomeTiburtina Bus Station0EconomyA Bus from Busitalia Rail Service goes from Central Bus Station, Siena (Italy) at 10/10/2026 8:40:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 10/10/2026 11:30:00 PM. 50 Economy ticket for $12 per person are available. Travel duration is 2h 50m
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Busitalia Fast3h 0m08:30 PMSienaPiazza Antonio Gramsci11:30 PMRomeTiburtina Bus Station0EconomyA Bus from Busitalia Fast goes from Piazza Antonio Gramsci, Siena (Italy) at 10/10/2026 8:30:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 10/10/2026 11:30:00 PM. 50 Economy ticket for $12 per person are available. Travel duration is 3h 0m
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Itabus2h 50m09:25 AMSienaCentral Bus Station12:15 PMRomeTiburtina Bus Station0EconomyA Bus from Itabus goes from Central Bus Station, Siena (Italy) at 10/10/2026 9:25:00 AM to Tiburtina Bus Station, Rome (Italy) arriving at 10/10/2026 12:15:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 2h 50m
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Trenitalia4h 19m04:48 PMSienaTrain Station9:07 PMRomeTiburtina Train Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 10/10/2026 4:48:00 PM to Tiburtina Train Station, Rome (Italy) arriving at 10/10/2026 9:07:00 PM. 50 Economy ticket for $22 per person are available. Travel duration is 4h 19m
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Trenitalia4h 52m08:13 AMSienaTrain Station1:05 PMRomeTermini Central Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 10/10/2026 8:13:00 AM to Termini Central Station, Rome (Italy) arriving at 10/10/2026 1:05:00 PM. 50 Economy ticket for $24 per person are available. Travel duration is 4h 52m
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Trenitalia3h 40m01:25 PMSienaTrain Station5:05 PMRomeTermini Central Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 10/10/2026 1:25:00 PM to Termini Central Station, Rome (Italy) arriving at 10/10/2026 5:05:00 PM. 50 Economy ticket for $24 per person are available. Travel duration is 3h 40m
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Trenitalia5h 2m02:43 PMSienaTrain Station7:45 PMRomeTermini Central Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 10/10/2026 2:43:00 PM to Termini Central Station, Rome (Italy) arriving at 10/10/2026 7:45:00 PM. 50 Economy ticket for $24 per person are available. Travel duration is 5h 2m
Cheapest Buses Saturday
Cheapest Trains Saturday
What are the fastest trips from Siena to Rome?
You can get to Rome from Siena in just 2h 40m with a Bus from FlixBus. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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FlixBus2h 40m08:45 AMSienaTrain Station11:25 AMRomeTiburtina Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 10/4/2026 8:45:00 AM to Tiburtina Bus Station, Rome (Italy) arriving at 10/4/2026 11:25:00 AM. 50 Economy ticket for $8 per person are available. Travel duration is 2h 40m
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Itabus2h 50m09:25 AMSienaPiazza Antonio Gramsci12:15 PMRomeTiburtina Bus Station0EconomyA Bus from Itabus goes from Piazza Antonio Gramsci, Siena (Italy) at 10/4/2026 9:25:00 AM to Tiburtina Bus Station, Rome (Italy) arriving at 10/4/2026 12:15:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 2h 50m
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Busitalia Rail Service2h 50m08:40 PMSienaCentral Bus Station11:30 PMRomeTiburtina Bus Station0EconomyA Bus from Busitalia Rail Service goes from Central Bus Station, Siena (Italy) at 10/4/2026 8:40:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 10/4/2026 11:30:00 PM. 50 Economy ticket for $12 per person are available. Travel duration is 2h 50m
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Busitalia Fast3h 0m08:30 PMSienaPiazza Antonio Gramsci11:30 PMRomeTiburtina Bus Station0EconomyA Bus from Busitalia Fast goes from Piazza Antonio Gramsci, Siena (Italy) at 10/4/2026 8:30:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 10/4/2026 11:30:00 PM. 50 Economy ticket for $12 per person are available. Travel duration is 3h 0m
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Trenitalia4h 49m06:00 AMSienaTrain Station10:49 AMRomeTiburtina Train Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 10/4/2026 6:00:00 AM to Tiburtina Train Station, Rome (Italy) arriving at 10/4/2026 10:49:00 AM. 50 Economy ticket for $24 per person are available. Travel duration is 4h 49m
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Trenitalia5h 3m08:02 AMSienaTrain Station1:05 PMRomeTermini Central Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 10/4/2026 8:02:00 AM to Termini Central Station, Rome (Italy) arriving at 10/4/2026 1:05:00 PM. 50 Economy ticket for $24 per person are available. Travel duration is 5h 3m
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Trenitalia5h 33m04:02 PMSienaTrain Station9:35 PMRomeTermini Central Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 10/4/2026 4:02:00 PM to Termini Central Station, Rome (Italy) arriving at 10/4/2026 9:35:00 PM. 50 Economy ticket for $24 per person are available. Travel duration is 5h 33m
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Trenitalia5h 43m02:02 PMSienaTrain Station7:45 PMRomeTermini Central Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 10/4/2026 2:02:00 PM to Termini Central Station, Rome (Italy) arriving at 10/4/2026 7:45:00 PM. 50 Economy ticket for $24 per person are available. Travel duration is 5h 43m
Fastest Buses Sunday
Fastest Trains Sunday
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Itabus2h 50m09:25 AMSienaTrain Station12:15 PMRomeTiburtina Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 10/5/2026 9:25:00 AM to Tiburtina Bus Station, Rome (Italy) arriving at 10/5/2026 12:15:00 PM. 50 Premium Economy ticket for $8 per person are available. Travel duration is 2h 50m
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Busitalia Rail Service2h 50m08:40 PMSienaCentral Bus Station11:30 PMRomeTiburtina Bus Station0EconomyA Bus from Busitalia Rail Service goes from Central Bus Station, Siena (Italy) at 10/5/2026 8:40:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 10/5/2026 11:30:00 PM. 50 Economy ticket for $12 per person are available. Travel duration is 2h 50m
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Busitalia Fast2h 50m08:40 PMSienaTrain Station11:30 PMRomeTiburtina Bus Station0EconomyA Bus from Busitalia Fast goes from Train Station, Siena (Italy) at 10/5/2026 8:40:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 10/5/2026 11:30:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 2h 50m
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FlixBus2h 55m07:00 AMSienaTrain Station9:55 AMRomeTiburtina Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 10/5/2026 7:00:00 AM to Tiburtina Bus Station, Rome (Italy) arriving at 10/5/2026 9:55:00 AM. 50 Economy ticket for $7 per person are available. Travel duration is 2h 55m
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Trenitalia3h 40m01:25 PMSienaTrain Station5:05 PMRomeTermini Central Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 10/5/2026 1:25:00 PM to Termini Central Station, Rome (Italy) arriving at 10/5/2026 5:05:00 PM. 50 Economy ticket for $24 per person are available. Travel duration is 3h 40m
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Trenitalia3h 52m05:43 PMSienaTrain Station9:35 PMRomeTermini Central Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 10/5/2026 5:43:00 PM to Termini Central Station, Rome (Italy) arriving at 10/5/2026 9:35:00 PM. 50 Economy ticket for $24 per person are available. Travel duration is 3h 52m
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Trenitalia4h 52m08:13 AMSienaTrain Station1:05 PMRomeTermini Central Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 10/5/2026 8:13:00 AM to Termini Central Station, Rome (Italy) arriving at 10/5/2026 1:05:00 PM. 50 Economy ticket for $24 per person are available. Travel duration is 4h 52m
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Trenitalia4h 53m04:02 PMSienaTrain Station8:55 PMRomeTermini Central Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 10/5/2026 4:02:00 PM to Termini Central Station, Rome (Italy) arriving at 10/5/2026 8:55:00 PM. 50 Economy ticket for $24 per person are available. Travel duration is 4h 53m
Fastest Buses Monday
Fastest Trains Monday
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Itabus2h 50m01:45 PMSienaPiazza Antonio Gramsci4:35 PMRomeTiburtina Bus Station0EconomyA Bus from Itabus goes from Piazza Antonio Gramsci, Siena (Italy) at 10/6/2026 1:45:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 10/6/2026 4:35:00 PM. 50 Economy ticket for $6 per person are available. Travel duration is 2h 50m
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Busitalia Rail Service2h 50m08:40 PMSienaCentral Bus Station11:30 PMRomeTiburtina Bus Station0EconomyA Bus from Busitalia Rail Service goes from Central Bus Station, Siena (Italy) at 10/6/2026 8:40:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 10/6/2026 11:30:00 PM. 50 Economy ticket for $12 per person are available. Travel duration is 2h 50m
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Busitalia Fast2h 50m08:40 PMSienaTrain Station11:30 PMRomeTiburtina Bus Station0EconomyA Bus from Busitalia Fast goes from Train Station, Siena (Italy) at 10/6/2026 8:40:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 10/6/2026 11:30:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 2h 50m
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FlixBus3h 5m05:35 AMSienaTrain Station8:40 AMRomeTiburtina Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 10/6/2026 5:35:00 AM to Tiburtina Bus Station, Rome (Italy) arriving at 10/6/2026 8:40:00 AM. 50 Economy ticket for $7 per person are available. Travel duration is 3h 5m
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Trenitalia3h 40m01:25 PMSienaTrain Station5:05 PMRomeTermini Central Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 10/6/2026 1:25:00 PM to Termini Central Station, Rome (Italy) arriving at 10/6/2026 5:05:00 PM. 50 Economy ticket for $23 per person are available. Travel duration is 3h 40m
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Trenitalia4h 19m04:48 PMSienaTrain Station9:07 PMRomeTiburtina Train Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 10/6/2026 4:48:00 PM to Tiburtina Train Station, Rome (Italy) arriving at 10/6/2026 9:07:00 PM. 50 Economy ticket for $22 per person are available. Travel duration is 4h 19m
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Trenitalia4h 47m08:13 AMSienaTrain Station1:00 PMRomeTermini Central Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 10/6/2026 8:13:00 AM to Termini Central Station, Rome (Italy) arriving at 10/6/2026 1:00:00 PM. 50 Economy ticket for $23 per person are available. Travel duration is 4h 47m
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Trenitalia4h 53m04:02 PMSienaTrain Station8:55 PMRomeTermini Central Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 10/6/2026 4:02:00 PM to Termini Central Station, Rome (Italy) arriving at 10/6/2026 8:55:00 PM. 50 Economy ticket for $23 per person are available. Travel duration is 4h 53m
Fastest Buses Tuesday
Fastest Trains Tuesday
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Itabus2h 50m01:45 PMSienaTrain Station4:35 PMRomeTiburtina Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 10/7/2026 1:45:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 10/7/2026 4:35:00 PM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 2h 50m
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Itabus2h 50m04:25 PMSienaTrain Station7:15 PMRomeTiburtina Bus Station0Premium EconomyA Bus from Itabus goes from Train Station, Siena (Italy) at 10/7/2026 4:25:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 10/7/2026 7:15:00 PM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 2h 50m
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Busitalia Rail Service2h 50m08:40 PMSienaCentral Bus Station11:30 PMRomeTiburtina Bus Station0EconomyA Bus from Busitalia Rail Service goes from Central Bus Station, Siena (Italy) at 10/7/2026 8:40:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 10/7/2026 11:30:00 PM. 50 Economy ticket for $12 per person are available. Travel duration is 2h 50m
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Busitalia Rail Service3h 0m08:30 PMSienaPiazza Antonio Gramsci11:30 PMRomeTiburtina Bus Station0EconomyA Bus from Busitalia Rail Service goes from Piazza Antonio Gramsci, Siena (Italy) at 10/7/2026 8:30:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 10/7/2026 11:30:00 PM. 50 Economy ticket for $12 per person are available. Travel duration is 3h 0m
Fastest Buses Wednesday
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Busitalia Rail Service2h 40m08:50 PMSienaBus Stop11:30 PMRomeTiburtina Bus Station0EconomyA Bus from Busitalia Rail Service goes from Bus Stop, Siena (Italy) at 10/8/2026 8:50:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 10/8/2026 11:30:00 PM. 50 Economy ticket for $12 per person are available. Travel duration is 2h 40m
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Busitalia Rail Service2h 50m08:40 PMSienaPiazza Antonio Gramsci11:30 PMRomeTiburtina Bus Station0EconomyA Bus from Busitalia Rail Service goes from Piazza Antonio Gramsci, Siena (Italy) at 10/8/2026 8:40:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 10/8/2026 11:30:00 PM. 50 Economy ticket for $12 per person are available. Travel duration is 2h 50m
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Itabus2h 50m01:45 PMSienaPiazza Antonio Gramsci4:35 PMRomeTiburtina Bus Station0EconomyA Bus from Itabus goes from Piazza Antonio Gramsci, Siena (Italy) at 10/8/2026 1:45:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 10/8/2026 4:35:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 2h 50m
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Itabus2h 55m05:15 AMSienaPiazza Antonio Gramsci8:10 AMRomeTiburtina Bus Station0EconomyA Bus from Itabus goes from Piazza Antonio Gramsci, Siena (Italy) at 10/8/2026 5:15:00 AM to Tiburtina Bus Station, Rome (Italy) arriving at 10/8/2026 8:10:00 AM. 50 Economy ticket for $13 per person are available. Travel duration is 2h 55m
Fastest Buses Thursday
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Busitalia Rail Service2h 50m08:40 PMSienaCentral Bus Station11:30 PMRomeTiburtina Bus Station0EconomyA Bus from Busitalia Rail Service goes from Central Bus Station, Siena (Italy) at 10/9/2026 8:40:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 10/9/2026 11:30:00 PM. 50 Economy ticket for $12 per person are available. Travel duration is 2h 50m
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Itabus2h 50m09:25 AMSienaCentral Bus Station12:15 PMRomeTiburtina Bus Station0EconomyA Bus from Itabus goes from Central Bus Station, Siena (Italy) at 10/9/2026 9:25:00 AM to Tiburtina Bus Station, Rome (Italy) arriving at 10/9/2026 12:15:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 2h 50m
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Busitalia Fast3h 0m08:30 PMSienaPiazza Antonio Gramsci11:30 PMRomeTiburtina Bus Station0EconomyA Bus from Busitalia Fast goes from Piazza Antonio Gramsci, Siena (Italy) at 10/9/2026 8:30:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 10/9/2026 11:30:00 PM. 50 Economy ticket for $12 per person are available. Travel duration is 3h 0m
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FlixBus3h 5m05:35 AMSienaTrain Station8:40 AMRomeTiburtina Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 10/9/2026 5:35:00 AM to Tiburtina Bus Station, Rome (Italy) arriving at 10/9/2026 8:40:00 AM. 50 Economy ticket for $7 per person are available. Travel duration is 3h 5m
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Trenitalia3h 40m01:25 PMSienaTrain Station5:05 PMRomeTermini Central Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 10/9/2026 1:25:00 PM to Termini Central Station, Rome (Italy) arriving at 10/9/2026 5:05:00 PM. 50 Economy ticket for $24 per person are available. Travel duration is 3h 40m
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Trenitalia3h 52m05:43 PMSienaTrain Station9:35 PMRomeTermini Central Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 10/9/2026 5:43:00 PM to Termini Central Station, Rome (Italy) arriving at 10/9/2026 9:35:00 PM. 50 Economy ticket for $24 per person are available. Travel duration is 3h 52m
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Trenitalia4h 52m08:13 AMSienaTrain Station1:05 PMRomeTermini Central Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 10/9/2026 8:13:00 AM to Termini Central Station, Rome (Italy) arriving at 10/9/2026 1:05:00 PM. 50 Economy ticket for $24 per person are available. Travel duration is 4h 52m
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Trenitalia4h 53m04:02 PMSienaTrain Station8:55 PMRomeTermini Central Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 10/9/2026 4:02:00 PM to Termini Central Station, Rome (Italy) arriving at 10/9/2026 8:55:00 PM. 50 Economy ticket for $24 per person are available. Travel duration is 4h 53m
Fastest Buses Friday
Fastest Trains Friday
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Busitalia Rail Service2h 50m08:40 PMSienaCentral Bus Station11:30 PMRomeTiburtina Bus Station0EconomyA Bus from Busitalia Rail Service goes from Central Bus Station, Siena (Italy) at 10/10/2026 8:40:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 10/10/2026 11:30:00 PM. 50 Economy ticket for $12 per person are available. Travel duration is 2h 50m
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Itabus2h 50m09:25 AMSienaCentral Bus Station12:15 PMRomeTiburtina Bus Station0EconomyA Bus from Itabus goes from Central Bus Station, Siena (Italy) at 10/10/2026 9:25:00 AM to Tiburtina Bus Station, Rome (Italy) arriving at 10/10/2026 12:15:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 2h 50m
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Busitalia Fast3h 0m08:30 PMSienaPiazza Antonio Gramsci11:30 PMRomeTiburtina Bus Station0EconomyA Bus from Busitalia Fast goes from Piazza Antonio Gramsci, Siena (Italy) at 10/10/2026 8:30:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 10/10/2026 11:30:00 PM. 50 Economy ticket for $12 per person are available. Travel duration is 3h 0m
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FlixBus3h 5m05:35 AMSienaTrain Station8:40 AMRomeTiburtina Bus Station0EconomyA Bus from FlixBus goes from Train Station, Siena (Italy) at 10/10/2026 5:35:00 AM to Tiburtina Bus Station, Rome (Italy) arriving at 10/10/2026 8:40:00 AM. 50 Economy ticket for $7 per person are available. Travel duration is 3h 5m
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Trenitalia3h 40m01:25 PMSienaTrain Station5:05 PMRomeTermini Central Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 10/10/2026 1:25:00 PM to Termini Central Station, Rome (Italy) arriving at 10/10/2026 5:05:00 PM. 50 Economy ticket for $24 per person are available. Travel duration is 3h 40m
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Trenitalia3h 52m05:43 PMSienaTrain Station9:35 PMRomeTermini Central Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 10/10/2026 5:43:00 PM to Termini Central Station, Rome (Italy) arriving at 10/10/2026 9:35:00 PM. 50 Economy ticket for $24 per person are available. Travel duration is 3h 52m
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Trenitalia4h 19m04:48 PMSienaTrain Station9:07 PMRomeTiburtina Train Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 10/10/2026 4:48:00 PM to Tiburtina Train Station, Rome (Italy) arriving at 10/10/2026 9:07:00 PM. 50 Economy ticket for $22 per person are available. Travel duration is 4h 19m
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Trenitalia4h 52m08:13 AMSienaTrain Station1:05 PMRomeTermini Central Station0EconomyA Train from Trenitalia goes from Train Station, Siena (Italy) at 10/10/2026 8:13:00 AM to Termini Central Station, Rome (Italy) arriving at 10/10/2026 1:05:00 PM. 50 Economy ticket for $24 per person are available. Travel duration is 4h 52m
Fastest Buses Saturday
Fastest Trains Saturday
Here you will find all operators and timetables for a
Bus from Siena to Rome
What are the most popular stations in Siena and Rome?
In Siena, you will usually depart from Central Bus Station, Train Station or Bus Stop, while in Rome you will be arriving at Termini Bus Station, Tiburtina Train Station or Tiburtina Bus Station, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Rome from Siena? With 8 connections between 6 Carpool, Train and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Siena and Rome, you can pay as low as $6 with a Bus from Itabus.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Bus from FlixBus: you will get to Rome in just 2h 40m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Siena and Rome are Trenitalia, Itabus and Busitalia Rail Service, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Siena and Rome is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Castagno or to Settebagni, and look at flights from , and landing at Rome Ciampino Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Siena to Rome?
The most popular companies between Siena and Rome, are Trenitalia, Itabus and Busitalia Rail Service. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Itabus, Busitalia Rail Service, MarinoBus and 2 more.
Train companies: Trenitalia
All you need to know when you travel from Siena to Rome
Check all information on comfort and services on all modes of transports from Siena to Rome. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Siena to Rome
How can I reach Rome from Siena?
Every day, there are on average 8 connections between Carpool, Train and Bus, with which you can get to Rome from Siena.
How far is Rome from Siena?
The distance between Siena and Rome is 114.5 miles.
What is the most ecofriendly mode of transport between Siena and Rome?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 5 kgs of CO2, a train 6 kgs, a car 31 kgs, and a flight 45 kgs.
What is the cheapest mode of transport from Siena to Rome?
You can get to Rome with just $6 by taking a Bus from Itabus.
What is the fastest way to get from Siena to Rome?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Rome in just 2h 40m with a Bus from FlixBus.
More routes to Siena and to Rome
Looking for more options? Here you can see the most popular routes to Siena and to Rome. Simply click on a connection, and you’ll find all the details about the route!
- Trips to Siena
- Avellino to Siena
- Bergamo to Siena
- Bologna to Siena
- Caserta to Siena
- Cassino to Siena
- Chieti to Siena
- Fiumicino to Siena
- Florence to Siena
- Genoa to Siena
- Milan to Siena
- Naples to Siena
- Perugia to Siena
- Pescara to Siena
- Pisa to Siena
- Potenza to Siena
- Rome to Siena
- Salerno to Siena
- Turin to Siena
- Trips to Rome
- Bari to Rome
- Battipaglia to Rome
- Bologna to Rome
- Catania to Rome
- Catanzaro to Rome
- Chieti to Rome
- Ciampino to Rome
- Civitanova to Rome
- Civitavecchia to Rome
- Cosenza to Rome
- Fano to Rome
- Lamezia Terme to Rome
- Milan to Rome
- Naples to Rome
- Palermo to Rome
- Perugia to Rome
- Pescara to Rome
- Pordenone to Rome
- Potenza to Rome
- Rome Fiumicino Airport to Rome
- Salerno to Rome
- San Benedetto del Tronto to Rome
- Tagliacozzo to Rome
- Teramo to Rome
