Bus Brussels to Lyon - Compare all Companies

Compare all timetables for the bus from Brussels to Lyon

Here is a selection of the cheapest bus trips from the schedule from Brussels to Lyon from various bus operators like BlaBlaCar Bus or FlixBus for the next days.

today

$60

tomorrow

$54

Monday

$59

Tuesday

$53

Wednesday

$37

Thursday

$29

Friday

$57

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
BlaBlaCar Bus	10h 30m	4:55 PM	Brussels	Midi Bus Station	3:25 AM	Lyon	Perrache Bus Stop	Economy	$60	A Bus from BlaBlaCar Bus goes from Midi Bus Station, Brussels (Belgium) at 12/20/2025 4:55:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/21/2025 3:25:00 AM. 50 Economy ticket for $60 per person are available. Travel duration is 10h 30m
BlaBlaCar Bus	10h 5m	5:55 PM	Brussels	Midi Bus Station	4:00 AM	Lyon	Perrache Train Station	Economy	$64	A Bus from BlaBlaCar Bus goes from Midi Bus Station, Brussels (Belgium) at 12/20/2025 5:55:00 PM to Perrache Train Station, Lyon (France) arriving at 12/21/2025 4:00:00 AM. 50 Economy ticket for $64 per person are available. Travel duration is 10h 5m
BlaBlaCar Bus	10h 10m	7:05 PM	Brussels	Midi Bus Station	5:15 AM	Lyon	Perrache Bus Stop	Economy	$64	A Bus from BlaBlaCar Bus goes from Midi Bus Station, Brussels (Belgium) at 12/20/2025 7:05:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/21/2025 5:15:00 AM. 50 Economy ticket for $64 per person are available. Travel duration is 10h 10m
FlixBus	12h 20m	10:55 PM	Brussels	North Station	11:15 AM	Lyon	Perrache Bus Stop	Economy	$99	A Bus from FlixBus goes from North Station, Brussels (Belgium) at 12/20/2025 10:55:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/21/2025 11:15:00 AM. 50 Economy ticket for $99 per person are available. Travel duration is 12h 20m
FlixBus	10h 30m	8:15 PM	Brussels	Midi Bus Station	6:45 AM	Lyon	Perrache Bus Stop	Economy	$103	A Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 12/20/2025 8:15:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/21/2025 6:45:00 AM. 50 Economy ticket for $103 per person are available. Travel duration is 10h 30m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
BlaBlaCar Bus	11h 25m	7:20 AM	Brussels	Midi Bus Station	6:45 PM	Lyon	Perrache Bus Stop	Economy	$54	A Bus from BlaBlaCar Bus goes from Midi Bus Station, Brussels (Belgium) at 12/21/2025 7:20:00 AM to Perrache Bus Stop, Lyon (France) arriving at 12/21/2025 6:45:00 PM. 50 Economy ticket for $54 per person are available. Travel duration is 11h 25m
BlaBlaCar Bus	10h 30m	4:55 PM	Brussels	Midi Bus Station	3:25 AM	Lyon	Perrache Train Station	Economy	$59	A Bus from BlaBlaCar Bus goes from Midi Bus Station, Brussels (Belgium) at 12/21/2025 4:55:00 PM to Perrache Train Station, Lyon (France) arriving at 12/22/2025 3:25:00 AM. 50 Economy ticket for $59 per person are available. Travel duration is 10h 30m
BlaBlaCar Bus	10h 55m	12:55 PM	Brussels	Midi Bus Station	11:50 PM	Lyon	Perrache Train Station	Economy	$62	A Bus from BlaBlaCar Bus goes from Midi Bus Station, Brussels (Belgium) at 12/21/2025 12:55:00 PM to Perrache Train Station, Lyon (France) arriving at 12/21/2025 11:50:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 10h 55m
FlixBus	12h 20m	10:55 PM	Brussels	North Station	11:15 AM	Lyon	Perrache Bus Stop	Economy	$104	A Bus from FlixBus goes from North Station, Brussels (Belgium) at 12/21/2025 10:55:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/22/2025 11:15:00 AM. 50 Economy ticket for $104 per person are available. Travel duration is 12h 20m
FlixBus	13h 15m	1:30 AM	Brussels	Midi Bus Station	2:45 PM	Lyon	Perrache Bus Stop	Economy	$110	A Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 12/21/2025 1:30:00 AM to Perrache Bus Stop, Lyon (France) arriving at 12/21/2025 2:45:00 PM. 50 Economy ticket for $110 per person are available. Travel duration is 13h 15m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
BlaBlaCar Bus	10h 45m	1:30 PM	Brussels	Midi Bus Station	12:15 AM	Lyon	Perrache Train Station	Economy	$59	A Bus from BlaBlaCar Bus goes from Midi Bus Station, Brussels (Belgium) at 12/22/2025 1:30:00 PM to Perrache Train Station, Lyon (France) arriving at 12/23/2025 12:15:00 AM. 50 Economy ticket for $59 per person are available. Travel duration is 10h 45m
BlaBlaCar Bus	11h 25m	7:20 AM	Brussels	Midi Bus Station	6:45 PM	Lyon	Perrache Bus Stop	Economy	$64	A Bus from BlaBlaCar Bus goes from Midi Bus Station, Brussels (Belgium) at 12/22/2025 7:20:00 AM to Perrache Bus Stop, Lyon (France) arriving at 12/22/2025 6:45:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 11h 25m
BlaBlaCar Bus	10h 10m	3:30 PM	Brussels	Midi Bus Station	1:40 AM	Lyon	Perrache Train Station	Economy	$64	A Bus from BlaBlaCar Bus goes from Midi Bus Station, Brussels (Belgium) at 12/22/2025 3:30:00 PM to Perrache Train Station, Lyon (France) arriving at 12/23/2025 1:40:00 AM. 50 Economy ticket for $64 per person are available. Travel duration is 10h 10m
FlixBus	12h 20m	10:55 PM	Brussels	North Station	11:15 AM	Lyon	Perrache Bus Stop	Economy	$83	A Bus from FlixBus goes from North Station, Brussels (Belgium) at 12/22/2025 10:55:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/23/2025 11:15:00 AM. 50 Economy ticket for $83 per person are available. Travel duration is 12h 20m
FlixBus	12h 5m	4:40 PM	Brussels	North Station	4:45 AM	Lyon	Perrache Bus Stop	Economy	$84	A Bus from FlixBus goes from North Station, Brussels (Belgium) at 12/22/2025 4:40:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/23/2025 4:45:00 AM. 50 Economy ticket for $84 per person are available. Travel duration is 12h 5m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
BlaBlaCar Bus	10h 40m	5:20 PM	Brussels	North Station	4:00 AM	Lyon	Perrache Train Station	Economy	$53	A Bus from BlaBlaCar Bus goes from North Station, Brussels (Belgium) at 12/23/2025 5:20:00 PM to Perrache Train Station, Lyon (France) arriving at 12/24/2025 4:00:00 AM. 50 Economy ticket for $53 per person are available. Travel duration is 10h 40m
BlaBlaCar Bus	10h 35m	4:55 PM	Brussels	Midi Bus Station	3:30 AM	Lyon	Perrache Bus Stop	Economy	$60	A Bus from BlaBlaCar Bus goes from Midi Bus Station, Brussels (Belgium) at 12/23/2025 4:55:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/24/2025 3:30:00 AM. 50 Economy ticket for $60 per person are available. Travel duration is 10h 35m
BlaBlaCar Bus	11h 20m	2:20 PM	Brussels	Midi Bus Station	1:40 AM	Lyon	Perrache Bus Stop	Economy	$64	A Bus from BlaBlaCar Bus goes from Midi Bus Station, Brussels (Belgium) at 12/23/2025 2:20:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/24/2025 1:40:00 AM. 50 Economy ticket for $64 per person are available. Travel duration is 11h 20m
FlixBus	12h 5m	4:40 PM	Brussels	North Station	4:45 AM	Lyon	Perrache Bus Stop	Economy	$84	A Bus from FlixBus goes from North Station, Brussels (Belgium) at 12/23/2025 4:40:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/24/2025 4:45:00 AM. 50 Economy ticket for $84 per person are available. Travel duration is 12h 5m
FlixBus	11h 0m	3:30 PM	Brussels	North Station	2:30 AM	Lyon	Perrache Bus Stop	Economy	$85	A Bus from FlixBus goes from North Station, Brussels (Belgium) at 12/23/2025 3:30:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/24/2025 2:30:00 AM. 50 Economy ticket for $85 per person are available. Travel duration is 11h 0m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
BlaBlaCar Bus	10h 35m	4:55 PM	Brussels	Midi Bus Station	3:30 AM	Lyon	Perrache Train Station	Economy	$37	A Bus from BlaBlaCar Bus goes from Midi Bus Station, Brussels (Belgium) at 12/24/2025 4:55:00 PM to Perrache Train Station, Lyon (France) arriving at 12/25/2025 3:30:00 AM. 50 Economy ticket for $37 per person are available. Travel duration is 10h 35m
BlaBlaCar Bus	10h 10m	7:05 PM	Brussels	Midi Bus Station	5:15 AM	Lyon	Perrache Train Station	Economy	$44	A Bus from BlaBlaCar Bus goes from Midi Bus Station, Brussels (Belgium) at 12/24/2025 7:05:00 PM to Perrache Train Station, Lyon (France) arriving at 12/25/2025 5:15:00 AM. 50 Economy ticket for $44 per person are available. Travel duration is 10h 10m
BlaBlaCar Bus	10h 15m	7:05 PM	Brussels	Midi Bus Station	5:20 AM	Lyon	Perrache Train Station	Economy	$44	A Bus from BlaBlaCar Bus goes from Midi Bus Station, Brussels (Belgium) at 12/24/2025 7:05:00 PM to Perrache Train Station, Lyon (France) arriving at 12/25/2025 5:20:00 AM. 50 Economy ticket for $44 per person are available. Travel duration is 10h 15m
FlixBus	10h 30m	8:15 PM	Brussels	Midi Bus Station	6:45 AM	Lyon	Perrache Bus Stop	Economy	$76	A Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 12/24/2025 8:15:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/25/2025 6:45:00 AM. 50 Economy ticket for $76 per person are available. Travel duration is 10h 30m
FlixBus	12h 20m	10:55 PM	Brussels	North Station	11:15 AM	Lyon	Perrache Bus Stop	Economy	$88	A Bus from FlixBus goes from North Station, Brussels (Belgium) at 12/24/2025 10:55:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/25/2025 11:15:00 AM. 50 Economy ticket for $88 per person are available. Travel duration is 12h 20m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
BlaBlaCar Bus	10h 45m	1:30 PM	Brussels	Midi Bus Station	12:15 AM	Lyon	Perrache Train Station	Economy	$29	A Bus from BlaBlaCar Bus goes from Midi Bus Station, Brussels (Belgium) at 12/25/2025 1:30:00 PM to Perrache Train Station, Lyon (France) arriving at 12/26/2025 12:15:00 AM. 50 Economy ticket for $29 per person are available. Travel duration is 10h 45m
BlaBlaCar Bus	10h 35m	4:55 PM	Brussels	Midi Bus Station	3:30 AM	Lyon	Perrache Train Station	Economy	$29	A Bus from BlaBlaCar Bus goes from Midi Bus Station, Brussels (Belgium) at 12/25/2025 4:55:00 PM to Perrache Train Station, Lyon (France) arriving at 12/26/2025 3:30:00 AM. 50 Economy ticket for $29 per person are available. Travel duration is 10h 35m
BlaBlaCar Bus	10h 30m	4:55 PM	Brussels	Midi Bus Station	3:25 AM	Lyon	Perrache Train Station	Economy	$29	A Bus from BlaBlaCar Bus goes from Midi Bus Station, Brussels (Belgium) at 12/25/2025 4:55:00 PM to Perrache Train Station, Lyon (France) arriving at 12/26/2025 3:25:00 AM. 50 Economy ticket for $29 per person are available. Travel duration is 10h 30m
FlixBus	10h 30m	8:15 PM	Brussels	Midi Bus Station	6:45 AM	Lyon	Perrache Bus Stop	Economy	$78	A Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 12/25/2025 8:15:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/26/2025 6:45:00 AM. 50 Economy ticket for $78 per person are available. Travel duration is 10h 30m
FlixBus	12h 20m	10:55 PM	Brussels	North Station	11:15 AM	Lyon	Perrache Bus Stop	Economy	$82	A Bus from FlixBus goes from North Station, Brussels (Belgium) at 12/25/2025 10:55:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/26/2025 11:15:00 AM. 50 Economy ticket for $82 per person are available. Travel duration is 12h 20m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
BlaBlaCar Bus	11h 25m	2:15 AM	Brussels	Midi Bus Station	1:40 PM	Lyon	Perrache Bus Stop	Economy	$57	A Bus from BlaBlaCar Bus goes from Midi Bus Station, Brussels (Belgium) at 12/26/2025 2:15:00 AM to Perrache Bus Stop, Lyon (France) arriving at 12/26/2025 1:40:00 PM. 50 Economy ticket for $57 per person are available. Travel duration is 11h 25m
BlaBlaCar Bus	11h 35m	6:05 AM	Brussels	Midi Bus Station	5:40 PM	Lyon	Perrache Bus Stop	Economy	$64	A Bus from BlaBlaCar Bus goes from Midi Bus Station, Brussels (Belgium) at 12/26/2025 6:05:00 AM to Perrache Bus Stop, Lyon (France) arriving at 12/26/2025 5:40:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 11h 35m
BlaBlaCar Bus	10h 55m	12:55 PM	Brussels	Midi Bus Station	11:50 PM	Lyon	Perrache Bus Stop	Economy	$64	A Bus from BlaBlaCar Bus goes from Midi Bus Station, Brussels (Belgium) at 12/26/2025 12:55:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/26/2025 11:50:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 10h 55m
FlixBus	12h 20m	10:55 PM	Brussels	North Station	11:15 AM	Lyon	Perrache Bus Stop	Economy	$90	A Bus from FlixBus goes from North Station, Brussels (Belgium) at 12/26/2025 10:55:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/27/2025 11:15:00 AM. 50 Economy ticket for $90 per person are available. Travel duration is 12h 20m
FlixBus	10h 45m	3:10 PM	Brussels	Midi Bus Station	1:55 AM	Lyon	Perrache Bus Stop	Economy	$105	A Bus from FlixBus goes from Midi Bus Station, Brussels (Belgium) at 12/26/2025 3:10:00 PM to Perrache Bus Stop, Lyon (France) arriving at 12/27/2025 1:55:00 AM. 50 Economy ticket for $105 per person are available. Travel duration is 10h 45m

Best Price Offer: The price for the cheapest bus from Brussels to Lyon is $22 on 12/31/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between Brussels and Lyon

See here how frequent the connections between Brussels and Lyon are, during different times and days of the week.

Sunday is the busiest day, with more than 55 daily buses from Brussels to Lyon. Saturday has instead the fewest connections, with only 25 daily coaches between Brussels and Lyon.

The busiest time of the day is the Afternoon, with 128 buses from Brussels to Lyon, while Night sees the fewest connections between Brussels and Lyon, with 52 offers.

Facts about the bus from Brussels to Lyon

Compare all providers like BlaBlaCar Bus and FlixBus that travel 41 times every day by bus from Brussels to Lyon in one click! Book your bus ticket from Brussels to Lyon starting from $22!

Cheapest Bus	$22
Fastest Bus	9h 45m
Earliest Bus	11:40 AM
Latest Bus	10:55 PM
Daily Bus Routes	41 Ø
Distance	352.7 miles
Bus Companies	BlaBlaCar Bus and FlixBus

Cheapest bus connections from Brussels to Lyon

Every day, 41 buses from 2 bus companies leave Brussels for Lyon: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/20/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 12/14

Monday 12/15

Tuesday 12/16

Wednesday 12/17

Thursday 12/18

Friday 12/19

Saturday 12/20

$64

Sunday 12/21

$59

Monday 12/22

$83

Tuesday 12/23

$76

Wednesday 12/24

$37

Thursday 12/25

$29

Friday 12/26

$70

Saturday 12/27

$102

Sunday 12/28

$95

Monday 12/29

$83

Tuesday 12/30

$42

Wednesday 12/31

$22

Thursday 01/01

$47

Friday 01/02

$64

Saturday 01/03

$66

Sunday 01/04

$64

Monday 01/05

$25

Tuesday 01/06

$36

Wednesday 01/07

$32

Thursday 01/08

$27

Friday 01/09

$27

Saturday 01/10

The cheapest time to travel from Brussels to Lyon

See here on which day and which time of the day you can find the cheapest bus ticket from Brussels to Lyon, for the next 30 days.

With a price starting from $22, Wednesday is the cheapest day for a bus from Brussels to Lyon. Sunday instead is the most expensive day with prices starting from $36.

Night is the cheapest day time for bus tickets from Brussels to Lyon, with $22. Morning is the most expensive time of the day with prices starting from $32.

How to save money travelling from Brussels to Lyon

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Brussels to Lyon in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Brussels to Lyon, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Brussels to Lyon are also emptier.

All bus stations and stops in Brussels and Lyon

In the map below, you can see where to find all bus stations in Brussels and Lyon.

Midi Bus Station

Avenue Fonsny 1

North Station

Rue du Progrès 80

Congrès

Boulevard Pachéco 7

Central Station

Delta

PONT DU, Boulevard des Invalides, 1160 BRUXELLES, Belgium

Perrache Bus Stop

Cours de Verdun 14

Pont Kitchener R.G. Bus Stop

Cours de Verdun

Maison Carrée Bus Stop

Les Charrières 69570

Girondins - Yves Farge Bus Stop

Saint Paul Train Station

Service and Comfort on the bus from Brussels to Lyon

Want to know which seat classes are available on the buses from Brussels to Lyon? Or which bus companies serve the route Brussels to Lyon? Below you will find answers to your questions.

FAQs about the Brussels to Lyon bus

How much does a Brussels Lyon bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $22 and takes 10h 45m to reach Lyon. Compare offers to save money!

How much could I save by comparing buses from Brussels to Lyon?

This route is offered by 2 companies with a range of ticket prices between $22 and $227. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Lyon.

On average, how many connections are available from Brussels to Lyon each day?

Every day, the Brussels to Lyon bus route is served by approximately 41 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Brussels to Lyon take?

The fastest bus from Brussels to Lyon is offered by BlaBlaCar Bus and takes 9h 45m. Bus tickets for this connection cost $94. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Brussels to Lyon?

The earliest bus arriving in Lyon from Brussels starts at 11:40 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Brussels to Lyon?

The latest bus trip departing from Brussels for Lyon starts at 10:55 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Brussels Lyon route?

When traveling by bus from Brussels to Lyon, passengers can travel with BlaBlaCar Bus and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Brussels and Lyon?

You can check all the direct connections between Brussels and Lyon by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: BlaBlaCar Bus and FlixBus.

What can I take with me on the Brussels to Lyon bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Brussels Lyon bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Brussels Lyon bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Brussels to Lyon on your planned travel date.

How does CheckMyBus find the best bus deals from Brussels to Lyon?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 41 daily trips between Brussels and Lyon. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Brussels to Lyon?

Prices and availability for 41 trips between Brussels and Lyon change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Brussels to Lyon

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Brussels and to Lyon

Here’s an overview of the most popular bus routes to Brussels and to Lyon. Simply click on the connection of your choice, and you will find all the details about your bus route!