Bus Buffalo, NY to Lake City, FL - Compare all Companies

Compare all timetables for the bus from Buffalo, NY to Lake City, FL

Here is a selection of the cheapest bus trips from the schedule from Buffalo, NY to Lake City, FL from various bus operators like Greyhound US or FlixBus for the next days.

today

$225

tomorrow

$216

Saturday

$216

Sunday

Monday

Tuesday

$216

Wednesday

Cheapest bus trips today
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	34h 5m	11:05 PM	Buffalo, NY	Central Bus Station	9:10 AM	Lake City, FL	Bus Stop		Economy	$225	A Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 9/3/2026 11:05:00 PM to Bus Stop, Lake City, FL (USA) arriving at 9/5/2026 9:10:00 AM. 50 Economy ticket for $225 per person are available. Travel duration is 34h 5m
	FlixBus	41h 16m	11:59 PM	Buffalo, NY	Central Bus Station	5:15 PM	Lake City, FL	Bus Stop		Economy	$255	A Bus from FlixBus goes from Central Bus Station, Buffalo, NY (USA) at 9/3/2026 11:59:00 PM to Bus Stop, Lake City, FL (USA) arriving at 9/5/2026 5:15:00 PM. 50 Economy ticket for $255 per person are available. Travel duration is 41h 16m

Did you know that if you travel from Buffalo, NY to Lake City, FL via Atlanta, GA, you can save more than $65? You can find the corresponding connections below.
- FlixBus
  
  46h 40m
  
  0
  
  10:30 AM
  
  Buffalo, NY
  Central Bus Station
  
  2:10 PM
  
  Atlanta, GA
  Garnett Transit Station
  
  0
  
  Economy
  
  $107
  
  A Bus from FlixBus goes from Central Bus Station, Buffalo, NY (USA) at 9/5/2026 10:30:00 AM to Garnett Transit Station, Atlanta, GA (USA) arriving at 9/6/2026 2:10:00 PM. 50 Economy ticket for $107 per person are available. Travel duration is 27h 40m
- FlixBus
  
  8h 45m
  
  0
  
  12:25 AM
  
  Atlanta, GA
  Garnett Transit Station
  
  9:10 AM
  
  Lake City, FL
  Bus Stop
  
  0
  
  Economy
  
  $53
  
  A Bus from FlixBus goes from Garnett Transit Station, Atlanta, GA (USA) at 9/7/2026 12:25:00 AM to Bus Stop, Lake City, FL (USA) arriving at 9/7/2026 9:10:00 AM. 50 Economy ticket for $53 per person are available. Travel duration is 8h 45m
Travel time is 12h 35m longer, but you will save $65

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	33h 20m	7:55 AM	Buffalo, NY	Central Bus Station	5:15 PM	Lake City, FL	Bus Stop	Economy	$216	A Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 9/4/2026 7:55:00 AM to Bus Stop, Lake City, FL (USA) arriving at 9/5/2026 5:15:00 PM. 50 Economy ticket for $216 per person are available. Travel duration is 33h 20m
FlixBus	41h 16m	11:59 PM	Buffalo, NY	Central Bus Station	5:15 PM	Lake City, FL	Bus Stop	Economy	$218	A Bus from FlixBus goes from Central Bus Station, Buffalo, NY (USA) at 9/4/2026 11:59:00 PM to Bus Stop, Lake City, FL (USA) arriving at 9/6/2026 5:15:00 PM. 50 Economy ticket for $218 per person are available. Travel duration is 41h 16m
Greyhound US	34h 5m	11:05 PM	Buffalo, NY	Central Bus Station	9:10 AM	Lake City, FL	Bus Stop	Economy	$223	A Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 9/4/2026 11:05:00 PM to Bus Stop, Lake City, FL (USA) arriving at 9/6/2026 9:10:00 AM. 50 Economy ticket for $223 per person are available. Travel duration is 34h 5m

Did you know that if you travel from Buffalo, NY to Lake City, FL via Atlanta, GA, you can save more than $56? You can find the corresponding connections below.
- FlixBus
  
  46h 40m
  
  0
  
  10:30 AM
  
  Buffalo, NY
  Central Bus Station
  
  2:10 PM
  
  Atlanta, GA
  Garnett Transit Station
  
  0
  
  Economy
  
  $107
  
  A Bus from FlixBus goes from Central Bus Station, Buffalo, NY (USA) at 9/5/2026 10:30:00 AM to Garnett Transit Station, Atlanta, GA (USA) arriving at 9/6/2026 2:10:00 PM. 50 Economy ticket for $107 per person are available. Travel duration is 27h 40m
- FlixBus
  
  8h 45m
  
  0
  
  12:25 AM
  
  Atlanta, GA
  Garnett Transit Station
  
  9:10 AM
  
  Lake City, FL
  Bus Stop
  
  0
  
  Economy
  
  $53
  
  A Bus from FlixBus goes from Garnett Transit Station, Atlanta, GA (USA) at 9/7/2026 12:25:00 AM to Bus Stop, Lake City, FL (USA) arriving at 9/7/2026 9:10:00 AM. 50 Economy ticket for $53 per person are available. Travel duration is 8h 45m
Travel time is 13h 20m longer, but you will save $56

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	33h 20m	7:55 AM	Buffalo, NY	Central Bus Station	5:15 PM	Lake City, FL	Bus Stop	Economy	$216	A Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 9/5/2026 7:55:00 AM to Bus Stop, Lake City, FL (USA) arriving at 9/6/2026 5:15:00 PM. 50 Economy ticket for $216 per person are available. Travel duration is 33h 20m
Greyhound US	34h 5m	11:05 PM	Buffalo, NY	Central Bus Station	9:10 AM	Lake City, FL	Bus Stop	Economy	$216	A Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 9/5/2026 11:05:00 PM to Bus Stop, Lake City, FL (USA) arriving at 9/7/2026 9:10:00 AM. 50 Economy ticket for $216 per person are available. Travel duration is 34h 5m
FlixBus	41h 16m	11:59 PM	Buffalo, NY	Central Bus Station	5:15 PM	Lake City, FL	Bus Stop	Economy	$236	A Bus from FlixBus goes from Central Bus Station, Buffalo, NY (USA) at 9/5/2026 11:59:00 PM to Bus Stop, Lake City, FL (USA) arriving at 9/7/2026 5:15:00 PM. 50 Economy ticket for $236 per person are available. Travel duration is 41h 16m

Did you know that if you travel from Buffalo, NY to Lake City, FL via Tallahassee, FL, you can save more than $68? You can find the corresponding connections below.
- Greyhound US
  
  38h 25m
  
  0
  
  11:05 PM
  
  Buffalo, NY
  Central Bus Station
  
  10:50 AM
  
  Tallahassee, FL
  Greyhound Bus Station
  
  0
  
  Economy
  
  $124
  
  A Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 9/6/2026 11:05:00 PM to Greyhound Bus Station, Tallahassee, FL (USA) arriving at 9/8/2026 10:50:00 AM. 50 Economy ticket for $124 per person are available. Travel duration is 35h 45m
- Greyhound US
  
  2h 5m
  
  0
  
  11:25 AM
  
  Tallahassee, FL
  Greyhound Bus Station
  
  1:30 PM
  
  Lake City, FL
  Bus Stop
  
  0
  
  Economy
  
  $24
  
  A Bus from Greyhound US goes from Greyhound Bus Station, Tallahassee, FL (USA) at 9/8/2026 11:25:00 AM to Bus Stop, Lake City, FL (USA) arriving at 9/8/2026 1:30:00 PM. 50 Economy ticket for $24 per person are available. Travel duration is 2h 5m
Travel time is 5h 5m longer, but you will save $68

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	34h 5m	11:05 PM	Buffalo, NY	Central Bus Station	9:10 AM	Lake City, FL	Bus Stop	Economy	$216	A Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 9/8/2026 11:05:00 PM to Bus Stop, Lake City, FL (USA) arriving at 9/10/2026 9:10:00 AM. 50 Economy ticket for $216 per person are available. Travel duration is 34h 5m
FlixBus	41h 16m	11:59 PM	Buffalo, NY	Central Bus Station	5:15 PM	Lake City, FL	Bus Stop	Economy	$218	A Bus from FlixBus goes from Central Bus Station, Buffalo, NY (USA) at 9/8/2026 11:59:00 PM to Bus Stop, Lake City, FL (USA) arriving at 9/10/2026 5:15:00 PM. 50 Economy ticket for $218 per person are available. Travel duration is 41h 16m
FlixBus	35h 45m	5:30 AM	Buffalo, NY	Central Bus Station	5:15 PM	Lake City, FL	Bus Stop	Economy	$220	A Bus from FlixBus goes from Central Bus Station, Buffalo, NY (USA) at 9/8/2026 5:30:00 AM to Bus Stop, Lake City, FL (USA) arriving at 9/9/2026 5:15:00 PM. 50 Economy ticket for $220 per person are available. Travel duration is 35h 45m

Did you know that if you travel from Buffalo, NY to Lake City, FL via Tallahassee, FL, you can save more than $93? You can find the corresponding connections below.
- Greyhound US
  
  38h 25m
  
  0
  
  11:05 PM
  
  Buffalo, NY
  Central Bus Station
  
  10:50 AM
  
  Tallahassee, FL
  Greyhound Bus Station
  
  0
  
  Economy
  
  $103
  
  A Bus from Greyhound US goes from Central Bus Station, Buffalo, NY (USA) at 9/9/2026 11:05:00 PM to Greyhound Bus Station, Tallahassee, FL (USA) arriving at 9/11/2026 10:50:00 AM. 50 Economy ticket for $103 per person are available. Travel duration is 35h 45m
- Greyhound US
  
  2h 5m
  
  0
  
  11:25 AM
  
  Tallahassee, FL
  Greyhound Bus Station
  
  1:30 PM
  
  Lake City, FL
  Bus Stop
  
  0
  
  Economy
  
  $20
  
  A Bus from Greyhound US goes from Greyhound Bus Station, Tallahassee, FL (USA) at 9/11/2026 11:25:00 AM to Bus Stop, Lake City, FL (USA) arriving at 9/11/2026 1:30:00 PM. 50 Economy ticket for $20 per person are available. Travel duration is 2h 5m
Travel time is 4h 20m longer, but you will save $93

Best Price Offer: The price for the cheapest bus from Buffalo, NY to Lake City, FL is $215 on 8/30/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Buffalo, NY and Lake City, FL

See here how frequent the connections between Buffalo, NY and Lake City, FL are, during different times and days of the week.

Tuesday is the busiest day, with more than 3 daily buses from Buffalo, NY to Lake City, FL. Thursday has instead the fewest connections, with only 2 daily coaches between Buffalo, NY and Lake City, FL.

The busiest time of the day is the Evening, with 8 buses from Buffalo, NY to Lake City, FL, while Night sees the fewest connections between Buffalo, NY and Lake City, FL, with 1 offers.

Facts about the bus from Buffalo, NY to Lake City, FL

Compare all providers like Greyhound US and FlixBus that travel 2 times every day by bus from Buffalo, NY to Lake City, FL in one click! Book your bus ticket from Buffalo, NY to Lake City, FL starting from $215!

Cheapest Bus	$215
Fastest Bus	33h 20m
Earliest Bus	11:05 PM
Latest Bus	11:59 PM
Daily Bus Routes	2 Ø
Distance	901.6 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from Buffalo, NY to Lake City, FL

Every day, 2 buses from 2 bus companies leave Buffalo, NY for Lake City, FL: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 09/03/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 08/30

Monday 08/31

Tuesday 09/01

Wednesday 09/02

Thursday 09/03

$239

Friday 09/04

$228

Saturday 09/05

$216

Sunday 09/06

Monday 09/07

Tuesday 09/08

$216

Wednesday 09/09

$217

Thursday 09/10

$219

Friday 09/11

$223

Saturday 09/12

$218

Sunday 09/13

$216

Monday 09/14

$225

Tuesday 09/15

$220

Wednesday 09/16

Thursday 09/17

$226

Friday 09/18

Saturday 09/19

$219

Sunday 09/20

$220

Monday 09/21

$223

Tuesday 09/22

$221

Wednesday 09/23

$220

Thursday 09/24

Friday 09/25

$223

Saturday 09/26

The cheapest time to travel from Buffalo, NY to Lake City, FL

See here on which day and which time of the day you can find the cheapest bus ticket from Buffalo, NY to Lake City, FL, for the next 30 days.

With a price starting from $216, Friday is the cheapest day for a bus from Buffalo, NY to Lake City, FL. Thursday instead is the most expensive day with prices starting from $219.

Morning is the cheapest day time for bus tickets from Buffalo, NY to Lake City, FL, with $214. Evening is the most expensive time of the day with prices starting from $216.

How to save money travelling from Buffalo, NY to Lake City, FL

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Buffalo, NY to Lake City, FL in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Buffalo, NY to Lake City, FL, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Buffalo, NY to Lake City, FL are also emptier.

Beloved bus companies from Buffalo, NY to Lake City, FL

These are the most booked bus companies between Buffalo, NY to Lake City, FL from our users.

FlixBus from Buffalo, NY to Lake City, FL

Here you will find the key facts about the FlixBus bus route Buffalo, NY to Lake City, FL:

Cheapest Price	$218
Fastest Bus	35h 45m
Earliest Bus	11:59 PM
Last Bus	11:59 PM
Daily Connections	1 Ø
Found on	8/8/2026

All bus stations and stops in Buffalo, NY and Lake City, FL

In the map below, you can see where to find all bus stations in Buffalo, NY and Lake City, FL.

Central Bus Station

Ellicott Street 181

MTC / Downtown Terminal

Ellicott Street 181

Maple Road Gulf

Maple Rd 4641

Cleveland Hall

Asia Food Market

Niagara Falls Blvd 2055

Bus Stop

S Marion Ave 251

Lake City Bus Stop

Service and Comfort on the bus from Buffalo, NY to Lake City, FL

Want to know which seat classes are available on the buses from Buffalo, NY to Lake City, FL? Or which bus companies serve the route Buffalo, NY to Lake City, FL? Below you will find answers to your questions.

FAQs about the Buffalo, NY to Lake City, FL bus

How much does a Buffalo, NY Lake City, FL bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $215 and takes 33h 20m to reach Lake City, FL. Compare offers to save money!

How much could I save by comparing buses from Buffalo, NY to Lake City, FL?

This route is offered by 2 companies with a range of ticket prices between $215 and $255. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Lake City, FL.

On average, how many connections are available from Buffalo, NY to Lake City, FL each day?

Every day, the Buffalo, NY to Lake City, FL bus route is served by approximately 2 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Buffalo, NY to Lake City, FL take?

The fastest bus from Buffalo, NY to Lake City, FL is offered by Greyhound US and takes 33h 20m. Bus tickets for this connection cost $216. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Buffalo, NY to Lake City, FL?

The earliest bus arriving in Lake City, FL from Buffalo, NY starts at 11:05 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Buffalo, NY to Lake City, FL?

The latest bus trip departing from Buffalo, NY for Lake City, FL starts at 11:59 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Buffalo, NY Lake City, FL route?

When traveling by bus from Buffalo, NY to Lake City, FL, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Buffalo, NY and Lake City, FL?

You can check all the direct connections between Buffalo, NY and Lake City, FL by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Buffalo, NY to Lake City, FL bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Buffalo, NY Lake City, FL bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Buffalo, NY Lake City, FL bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Buffalo, NY to Lake City, FL on your planned travel date.

How does CheckMyBus find the best bus deals from Buffalo, NY to Lake City, FL?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 2 daily trips between Buffalo, NY and Lake City, FL. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Buffalo, NY to Lake City, FL?

Prices and availability for 2 trips between Buffalo, NY and Lake City, FL change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Buffalo, NY to Lake City, FL

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Buffalo, NY and to Lake City, FL

Here’s an overview of the most popular bus routes to Buffalo, NY and to Lake City, FL. Simply click on the connection of your choice, and you will find all the details about your bus route!