Which bus from Cheyenne, WY to Knoxville, TN is the cheapest?

Compare all bus companies and find the best price: Bus tickets from $221
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Compare all timetables for the bus from Cheyenne, WY to Knoxville, TN

Here is a selection of the cheapest bus trips from the schedule from Cheyenne, WY to Knoxville, TN from various bus operators like Greyhound US for the next days.

today
$222
tomorrow
$222
Wednesday
Thursday
Friday
Saturday
Sunday
$222

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 47h 40m 4:20 PM Cheyenne, WY Sinclair 6:00 PM Knoxville, TN Greyhound Bus Station  Economy $222
  • Did you know that if you travel from Cheyenne, WY to Knoxville, TN via Denver, you can save more than $76? You can find the corresponding connections below.
    • Greyhound US
      49h 10m
      0
      4:20 PM
      Cheyenne, WY
      Sinclair
      6:10 PM
      Denver
      Union Station
      0
      Greyhound US
      Economy
      $18
      • Waiting Time 2h 0m
    • Greyhound US
      45h 20m
      0
      8:10 PM
      Denver
      Union Station
      7:30 PM
      Knoxville, TN
      Greyhound Bus Station
      0
      Greyhound US
      Economy
      $128
    Travel Time is 0h 30m shorter, and you will save $76

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 47h 40m 4:20 PM Cheyenne, WY Sinclair 6:00 PM Knoxville, TN Greyhound Bus Station  Economy $222
  • Did you know that if you travel from Cheyenne, WY to Knoxville, TN via Denver, you can save more than $76? You can find the corresponding connections below.
    • Greyhound US
      49h 10m
      0
      4:20 PM
      Cheyenne, WY
      Sinclair
      6:10 PM
      Denver
      Union Station
      0
      Greyhound US
      Economy
      $18
      • Waiting Time 2h 0m
    • Greyhound US
      45h 20m
      0
      8:10 PM
      Denver
      Union Station
      7:30 PM
      Knoxville, TN
      Greyhound Bus Station
      0
      Greyhound US
      Economy
      $128
    Travel Time is 0h 30m shorter, and you will save $76

Cheapest bus trips Sunday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 47h 40m 4:20 PM Cheyenne, WY Sinclair 6:00 PM Knoxville, TN Greyhound Bus Station  Economy $222
  • Did you know that if you travel from Cheyenne, WY to Knoxville, TN via Denver, you can save more than $95? You can find the corresponding connections below.
    • Greyhound US
      47h 40m
      0
      4:20 PM
      Cheyenne, WY
      Roadway Inn
      6:10 PM
      Denver
      Union Station
      0
      Greyhound US
      Economy
      $14
      • Waiting Time 1h 15m
    • Greyhound US
      44h 35m
      0
      7:25 PM
      Denver
      Union Station
      6:00 PM
      Knoxville, TN
      Knoxville Area Transit Bus Stop
      0
      Greyhound US
      Economy
      $113
    Travel Time is 2h 0m shorter, and you will save $95

Best Price Offer: The price for the cheapest bus from Cheyenne, WY to Knoxville, TN is $221 on 4/19/2026. Flexible travelers save on ticket prices.


Facts about the bus from Cheyenne, WY to Knoxville, TN

Compare all providers like Greyhound US that travel 1 times every day by bus from Cheyenne, WY to Knoxville, TN in one click! Book your bus ticket from Cheyenne, WY to Knoxville, TN starting from $221!

Cheapest Bus $221
Fastest Bus 49h 40m
Earliest Bus 4:20 PM
Latest Bus 4:20 PM
Daily Bus Routes 1 Ø
Distance 1,181.9 miles
Bus Companies Greyhound US

Cheapest bus connections from Cheyenne, WY to Knoxville, TN

Every day, 1 buses from 1 bus companies leave Cheyenne, WY for Knoxville, TN: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 04/20/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 04/19
Monday 04/20
$222
Tuesday 04/21
$222
Wednesday 04/22
Thursday 04/23
Friday 04/24
Saturday 04/25
Sunday 04/26
$222
Monday 04/27
$222
Tuesday 04/28
$222
Wednesday 04/29
Thursday 04/30
Friday 05/01
Saturday 05/02
$221
Sunday 05/03
Monday 05/04
Tuesday 05/05
Wednesday 05/06
Thursday 05/07
Friday 05/08
$222
Saturday 05/09
Sunday 05/10
Monday 05/11
$225
Tuesday 05/12
$225
Wednesday 05/13
Thursday 05/14
$225
Friday 05/15
Saturday 05/16

How to save money travelling from Cheyenne, WY to Knoxville, TN

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Cheyenne, WY to Knoxville, TN in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Cheyenne, WY to Knoxville, TN, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Cheyenne, WY to Knoxville, TN are also emptier.

All bus stations and stops in Cheyenne, WY and Knoxville, TN

In the map below, you can see where to find all bus stations in Cheyenne, WY and Knoxville, TN.

Service and Comfort on the bus from Cheyenne, WY to Knoxville, TN

Want to know which seat classes are available on the buses from Cheyenne, WY to Knoxville, TN? Or which bus companies serve the route Cheyenne, WY to Knoxville, TN? Below you will find answers to your questions.

FAQs about the Cheyenne, WY to Knoxville, TN bus

How much does a Cheyenne, WY Knoxville, TN bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $221 and takes 49h 40m to reach Knoxville, TN. Compare offers to save money!

How much could I save by comparing buses from Cheyenne, WY to Knoxville, TN?

This route is offered by 1 companies with a range of ticket prices between $221 and $222. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Knoxville, TN.

On average, how many connections are available from Cheyenne, WY to Knoxville, TN each day?

Every day, the Cheyenne, WY to Knoxville, TN bus route is served by approximately 1 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Cheyenne, WY to Knoxville, TN take?

The fastest bus from Cheyenne, WY to Knoxville, TN is offered by Greyhound US and takes 49h 40m. Bus tickets for this connection cost $222. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Cheyenne, WY to Knoxville, TN?

The earliest bus arriving in Knoxville, TN from Cheyenne, WY starts at 4:20 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Cheyenne, WY to Knoxville, TN?

The latest bus trip departing from Cheyenne, WY for Knoxville, TN starts at 4:20 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Cheyenne, WY Knoxville, TN route?

When traveling by bus from Cheyenne, WY to Knoxville, TN, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Cheyenne, WY and Knoxville, TN?

You can check all the direct connections between Cheyenne, WY and Knoxville, TN by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Cheyenne, WY to Knoxville, TN bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Cheyenne, WY Knoxville, TN bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Cheyenne, WY Knoxville, TN bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Cheyenne, WY to Knoxville, TN on your planned travel date.

How does CheckMyBus find the best bus deals from Cheyenne, WY to Knoxville, TN?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 1 daily trips between Cheyenne, WY and Knoxville, TN. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Cheyenne, WY to Knoxville, TN?

Prices and availability for 1 trips between Cheyenne, WY and Knoxville, TN change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Cheyenne, WY to Knoxville, TN

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Cheyenne, WY and to Knoxville, TN

Here’s an overview of the most popular bus routes to Cheyenne, WY and to Knoxville, TN. Simply click on the connection of your choice, and you will find all the details about your bus route!
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Buses Port Saint Lucie, FL to Cheyenne, WY Buses Port Saint Lucie, FL to Cheyenne, WY
Bus to Knoxville, TN from Oakland Bus to Knoxville, TN from Oakland
Bus from Ciudad Juárez to Knoxville, TN Bus from Ciudad Juárez to Knoxville, TN
Bus Conyers, GA to Knoxville, TN Bus Conyers, GA to Knoxville, TN
Bus to Knoxville, TN from Norfolk, VA Bus to Knoxville, TN from Norfolk, VA
Popular Airport Shuttles to Cheyenne, WY and to Knoxville, TN
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